Tryptophan-2,3-dioxygenase

Overview
NameTryptophan-2,3-dioxygenase
Smed IDSMED30007277
Length (bp)1298
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Tryptophan-2,3-dioxygenase (SMED30007277) t-SNE clustered cells

Violin plots show distribution of expression levels for Tryptophan-2,3-dioxygenase (SMED30007277) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tryptophan-2,3-dioxygenase (SMED30007277) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tryptophan-2,3-dioxygenase (SMED30007277) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007277

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30007277h1SMcG0001890 SmedASXL_009441SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017		whole organism asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30007277h1SMcG0001890 Contig48603newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30007277h1SMcG0001890 Contig48603uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30007277h1SMcG0001890 Contig7680uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30007277h1SMcG0001890 Contig7680newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30007277h1SMcG0001890 dd_Smed_v4_3550_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30007277h1SMcG0001890 dd_Smed_v4_3550_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30007277h1SMcG0001890 dd_Smed_v4_3550_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30007277h1SMcG0001890 dd_Smed_v4_3550_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30007277h1SMcG0001890 dd_Smed_v4_3550_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30007277h1SMcG0001890 SMU15031847dd_Smed_v4PMID:27240733
Stubenhaus et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
goblet cellSMED30007277h1SMcG0001890 dd_Smed_v6_3550_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Match: TDO2 (tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708])

HSP 1 Score: 316.235 bits (809), Expect = 4.528e-104
Identity = 165/320 (51.56%), Postives = 225/320 (70.31%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQ-IVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDF 1213
             YELWFKQI++E+DS++E+FQ   V DERNM  +++R+ RV +ILK LV Q SILETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+  F+ +    E +  S  E++L  L+E WLERTPG      NFW      + R L++ +  +I   +E  EK+   A+++K+K+   ++ DE  +  L+ +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++DID+ +TKWRYNHV MV RM+GSK GTGGSSGY YLRSTVSDRY  F DL NLSTYLIPR +IPK++  + + L   ++
Sbjct:   78 AYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGE--ENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF-IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEY 394
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Match: TDO2 (tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708])

HSP 1 Score: 316.235 bits (809), Expect = 4.528e-104
Identity = 165/320 (51.56%), Postives = 225/320 (70.31%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQ-IVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDF 1213
             YELWFKQI++E+DS++E+FQ   V DERNM  +++R+ RV +ILK LV Q SILETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+  F+ +    E +  S  E++L  L+E WLERTPG      NFW      + R L++ +  +I   +E  EK+   A+++K+K+   ++ DE  +  L+ +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++DID+ +TKWRYNHV MV RM+GSK GTGGSSGY YLRSTVSDRY  F DL NLSTYLIPR +IPK++  + + L   ++
Sbjct:   78 AYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGE--ENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF-IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEY 394
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Match: TDO2 (tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708])

HSP 1 Score: 83.9593 bits (206), Expect = 1.278e-19
Identity = 41/62 (66.13%), Postives = 50/62 (80.65%), Query Frame = 2 
Query:  353 IINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESR 538
            +++R+ RV +ILK LV Q SILETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  R
Sbjct:    4 VVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMR 65
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Match: TDO2 (tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708])

HSP 1 Score: 83.9593 bits (206), Expect = 1.278e-19
Identity = 41/62 (66.13%), Postives = 50/62 (80.65%), Query Frame = 2 
Query:  353 IINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESR 538
            +++R+ RV +ILK LV Q SILETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  R
Sbjct:    4 VVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMR 65
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Match: TDO2 (tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708])

HSP 1 Score: 62.003 bits (149), Expect = 4.159e-12
Identity = 30/46 (65.22%), Postives = 37/46 (80.43%), Query Frame = 2 
Query:  353 IINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSL 490
            +++R+ RV +ILK LV Q SILETMTA+DF DFR +L  ASGFQSL
Sbjct:    4 VVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSL 49
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Celegans
Match: tdo-2 (Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swiss-Prot;Acc:Q09474])

HSP 1 Score: 327.02 bits (837), Expect = 8.792e-109
Identity = 162/323 (50.15%), Postives = 221/323 (68.42%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDA--DSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEK-----KLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQ 1204
             +ELWFKQIIF++D+++++    ++DE     I++ L R+  IL  L +QI++L+TM+ +DF+DFR +L  ASGFQSLQFR+LENKLGV +E R++YN Q+YK+VF    +    V    +E+SL  L+E WLERTPG      D  FW  Y  +V +YL D     +AK    P       K LTA+Y K   ++++I D   + + I+ G +  S++A KGA+MI  YRD  RFSQPYQ+L+ ++DID+  TKWRYNHV++VQRM+G+K GTGGSSGY YLRSTVSDRY  F DL NLST+LIPREYIP LS  M++ LS+
Sbjct:   75 AHELWFKQIIFDLDNVRKLLNNTIVDETKTLKIVSGLDRMTKILSLLTEQITLLDTMSPLDFVDFRKYLTPASGFQSLQFRVLENKLGVRQERRIKYNAQHYKNVFNDTDLKTLNVTE--EEKSLLTLIESWLERTPGLKSTSEDEGFWIKYEKSVNKYLAD-----LAKQAADPSNTEEIAKQLTAEYHKTADAFQSILDPRQHEQHIRNGNRLLSHDATKGAMMIYFYRDMPRFSQPYQILTFLMDIDSLFTKWRYNHVLLVQRMLGAKQGTGGSSGYMYLRSTVSDRYKVFLDLFNLSTWLIPREYIPMLSPRMVKTLSE 390
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Celegans
Match: tdo-2 (Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swiss-Prot;Acc:Q09474])

HSP 1 Score: 327.02 bits (837), Expect = 8.792e-109
Identity = 162/323 (50.15%), Postives = 221/323 (68.42%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDA--DSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEK-----KLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQ 1204
             +ELWFKQIIF++D+++++    ++DE     I++ L R+  IL  L +QI++L+TM+ +DF+DFR +L  ASGFQSLQFR+LENKLGV +E R++YN Q+YK+VF    +    V    +E+SL  L+E WLERTPG      D  FW  Y  +V +YL D     +AK    P       K LTA+Y K   ++++I D   + + I+ G +  S++A KGA+MI  YRD  RFSQPYQ+L+ ++DID+  TKWRYNHV++VQRM+G+K GTGGSSGY YLRSTVSDRY  F DL NLST+LIPREYIP LS  M++ LS+
Sbjct:   75 AHELWFKQIIFDLDNVRKLLNNTIVDETKTLKIVSGLDRMTKILSLLTEQITLLDTMSPLDFVDFRKYLTPASGFQSLQFRVLENKLGVRQERRIKYNAQHYKNVFNDTDLKTLNVTE--EEKSLLTLIESWLERTPGLKSTSEDEGFWIKYEKSVNKYLAD-----LAKQAADPSNTEEIAKQLTAEYHKTADAFQSILDPRQHEQHIRNGNRLLSHDATKGAMMIYFYRDMPRFSQPYQILTFLMDIDSLFTKWRYNHVLLVQRMLGAKQGTGGSSGYMYLRSTVSDRYKVFLDLFNLSTWLIPREYIPMLSPRMVKTLSE 390
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Celegans
Match: tdo-2 (Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swiss-Prot;Acc:Q09474])

HSP 1 Score: 150.214 bits (378), Expect = 3.619e-44
Identity = 68/99 (68.69%), Postives = 82/99 (82.83%), Query Frame = 2 
Query:  908 LMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQ 1204
            +MI  YRD  RFSQPYQ+L+ ++DID+  TKWRYNHV++VQRM+G+K GTGGSSGY YLRSTVSDRY  F DL NLST+LIPREYIP LS  M++ LS+
Sbjct:    1 MMIYFYRDMPRFSQPYQILTFLMDIDSLFTKWRYNHVLLVQRMLGAKQGTGGSSGYMYLRSTVSDRYKVFLDLFNLSTWLIPREYIPMLSPRMVKTLSE 99
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Fly
Match: v (gene:FBgn0003965 transcript:FBtr0073386)

HSP 1 Score: 352.058 bits (902), Expect = 7.237e-119
Identity = 182/318 (57.23%), Postives = 228/318 (71.70%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLT---ADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RVRYN Q Y  VF  D  A+  + NS  + SL  L++RWLERTPG  ++  NFW  +  +V R+L    E Q+    E P +K       D EK ++ Y +I D   ++ L++RG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + ++L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYN-QKYSDVF-SDEEARNSIRNSEKDPSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFL----EAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKL 374
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Zebrafish
Match: tdo2b (tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc:334082])

HSP 1 Score: 317.005 bits (811), Expect = 1.223e-104
Identity = 157/327 (48.01%), Postives = 224/327 (68.50%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLR---RLSQMDFSYNS 1225
             YELWFKQI++E+DS++++F ++ V DERNM  +++R+ R+ +I K LVDQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLE K+GV++  RV YN+++Y+  F  +    E + +S  E +L  L+E+WLERTPG      NFW      +   LK   + Q+ K+++   K+ +  D  K+ +++  + D   +  L+ +GE+R SY A +GALMI+ YR+E RF  P+Q+L+ +++ID  +TKWRYNHV MV RMIGSK GTGGSSGY YLRSTVSDRY  F DL NL+T+L+PR ++PKL+  + +        D SYNS
Sbjct:   77 AYELWFKQILWELDSVRDLFIKKHVRDERNMLKVVSRIHRITMIFKLLVDQFAVLETMTALDFFDFREYLSPASGFQSLQFRLLEQKIGVADHLRVPYNRRHYRDNFHGE--ESETLLSSEQEPTLLQLVEQWLERTPGLEKDGFNFWGKLQANIEEGLKR-EKHQVEKMEDTEVKQEVLEDLNKQMETFTALFDSKRHEHLLSKGERRLSYKALQGALMINFYREEPRFQVPFQLLTALMEIDTLMTKWRYNHVCMVHRMIGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLATFLVPRSWVPKLNPNIHKFPYTAECYDSSYNS 400
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Zebrafish
Match: tdo2a (tryptophan 2,3-dioxygenase a [Source:NCBI gene;Acc:100008541])

HSP 1 Score: 305.834 bits (782), Expect = 2.662e-100
Identity = 156/310 (50.32%), Postives = 212/310 (68.39%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFW---ESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKL 1174
             YELWFKQ+++E+DS++E+F    V DERNM  +  R+ R+V+I + L+DQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV    RV YN+++Y+  F       E + +S  E +L  L+E+WLERTPG  +   NFW   E       R  K+  E + A       K+ + A+  K++  + ++ DE  ++ L+  G++R SY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RMIGSK GTGGSSGYQYLRSTVSDRY  F DL NL+T+LIPR+++PKL
Sbjct:   77 AYELWFKQVLWELDSVREIFISGHVRDERNMLKVNTRIHRIVMIFRLLLDQFAVLETMTALDFYDFREYLSPASGFQSLQFRLLENKIGVPHNQRVPYNRRHYRDNFRDQ--ESELLLHSEQEPTLLQLVEQWLERTPGLEEDGFNFWGKLEKNIFEGLRREKEHIEQKPA----SERKEEMLAELIKQRDIFLSLFDEKRHDHLVSTGQRRLSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKDGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLIPRDWVPKL 380
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Zebrafish
Match: tdo2a (tryptophan 2,3-dioxygenase a [Source:NCBI gene;Acc:100008541])

HSP 1 Score: 305.834 bits (782), Expect = 2.662e-100
Identity = 156/310 (50.32%), Postives = 212/310 (68.39%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFW---ESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKL 1174
             YELWFKQ+++E+DS++E+F    V DERNM  +  R+ R+V+I + L+DQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV    RV YN+++Y+  F       E + +S  E +L  L+E+WLERTPG  +   NFW   E       R  K+  E + A       K+ + A+  K++  + ++ DE  ++ L+  G++R SY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RMIGSK GTGGSSGYQYLRSTVSDRY  F DL NL+T+LIPR+++PKL
Sbjct:   77 AYELWFKQVLWELDSVREIFISGHVRDERNMLKVNTRIHRIVMIFRLLLDQFAVLETMTALDFYDFREYLSPASGFQSLQFRLLENKIGVPHNQRVPYNRRHYRDNFRDQ--ESELLLHSEQEPTLLQLVEQWLERTPGLEEDGFNFWGKLEKNIFEGLRREKEHIEQKPA----SERKEEMLAELIKQRDIFLSLFDEKRHDHLVSTGQRRLSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKDGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLIPRDWVPKL 380
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Zebrafish
Match: tdo2b (tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc:334082])

HSP 1 Score: 131.339 bits (329), Expect = 1.167e-35
Identity = 60/110 (54.55%), Postives = 87/110 (79.09%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKD 583
             YELWFKQI++E+DS++++F ++ V DERNM  +++R+ R+ +I K LVDQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLE K+GV++  RV YN+++Y+  F  +
Sbjct:   73 AYELWFKQILWELDSVRDLFIKKHVRDERNMLKVVSRIHRITMIFKLLVDQFAVLETMTALDFFDFREYLSPASGFQSLQFRLLEQKIGVADHLRVPYNRRHYRDNFHGE 182
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Xenopus
Match: tdo2 (tryptophan 2,3-dioxygenase [Source:NCBI gene;Acc:548450])

HSP 1 Score: 321.242 bits (822), Expect = 4.639e-106
Identity = 164/318 (51.57%), Postives = 222/318 (69.81%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQ-IVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGP---EKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQI++E+DS++E+FQ   V DERNM  ++ R+ R+ +ILK LV+Q S+LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV E  RV YN+++Y+  F+ +    E +  S  E +L  L+E WLERTPG  +   +FW      + R L    E+++  ++  P   EK+   A+ +K+K+ +  + DE  +  L+ +GE+R SY A KGALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RMIGSK GTGGSSGYQYLRSTVSDRY  F DL NLSTYL+PR ++P+L+  + + L
Sbjct:   78 AYELWFKQILWELDSVREIFQNGHVRDERNMLKVVTRIHRISMILKLLVEQFSVLETMTAMDFFDFRDYLSPASGFQSLQFRLLENKIGVPEILRVPYNRRHYRDNFKGE--TNELLLKSEQELTLLGLVEAWLERTPGLEEEGFHFWGKLEANIFRGL----EEELQTVKTKPDSEEKEEQLAELQKQKELFGALFDERRHEHLLSKGERRLSYKALKGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKAGTGGSSGYQYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPRLNPSIHKFL 389
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Mouse
Match: Tdo2 (tryptophan 2,3-dioxygenase [Source:MGI Symbol;Acc:MGI:1928486])

HSP 1 Score: 316.235 bits (809), Expect = 1.420e-104
Identity = 161/308 (52.27%), Postives = 216/308 (70.13%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQ-IVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLS 1177
             YELWFKQI++E+DS++E+FQ   V DERNM  +I R+ RVV+I K LV Q S+LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+  F  D    E +  S  E++L  L+E WLERTPG      NFW  +   + + L++ +    AK  +  EK+   A++ K+K+    + DE  ++ L+ +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RM+G+K GTGGSSGY YLRSTVSDRY  F DL NLSTYL+PR ++PK++
Sbjct:   59 AYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGD--YNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAK-TDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMN 363
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Mouse
Match: Tdo2 (tryptophan 2,3-dioxygenase [Source:MGI Symbol;Acc:MGI:1928486])

HSP 1 Score: 316.62 bits (810), Expect = 2.397e-104
Identity = 161/308 (52.27%), Postives = 216/308 (70.13%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQ-IVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLS 1177
             YELWFKQI++E+DS++E+FQ   V DERNM  +I R+ RVV+I K LV Q S+LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+  F  D    E +  S  E++L  L+E WLERTPG      NFW  +   + + L++ +    AK  +  EK+   A++ K+K+    + DE  ++ L+ +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RM+G+K GTGGSSGY YLRSTVSDRY  F DL NLSTYL+PR ++PK++
Sbjct:   78 AYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGD--YNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAK-TDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMN 382
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Match: sp|B3MQP7|T23O_DROAN (Tryptophan 2,3-dioxygenase OS=Drosophila ananassae OX=7217 GN=v PE=3 SV=1)

HSP 1 Score: 354.755 bits (909), Expect = 7.570e-119
Identity = 182/318 (57.23%), Postives = 227/318 (71.38%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGP---EKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RVRYN Q Y  VF  D  A   + +S  E SL  L++RWLERTPG  ++  NFWE +  +V ++L    E Q+    E P    K     D EK ++ Y +I D   ++ L++RG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + ++L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYN-QKYSDVFGGDEDALTAIRSSEQEPSLLELVQRWLERTPGLEESGFNFWEKFQQSVDKFL----EAQVHSAMEEPVERAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDESIRKKL 375
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Match: sp|P20351|T23O_DROME (Tryptophan 2,3-dioxygenase OS=Drosophila melanogaster OX=7227 GN=v PE=1 SV=1)

HSP 1 Score: 352.058 bits (902), Expect = 7.254e-118
Identity = 182/318 (57.23%), Postives = 228/318 (71.70%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLT---ADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RVRYN Q Y  VF  D  A+  + NS  + SL  L++RWLERTPG  ++  NFW  +  +V R+L    E Q+    E P +K       D EK ++ Y +I D   ++ L++RG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + ++L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYN-QKYSDVF-SDEEARNSIRNSEKDPSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFL----EAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKL 374
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Match: sp|Q24630|T23O_DROSI (Tryptophan 2,3-dioxygenase OS=Drosophila simulans OX=7240 GN=v PE=3 SV=1)

HSP 1 Score: 352.058 bits (902), Expect = 9.623e-118
Identity = 182/318 (57.23%), Postives = 227/318 (71.38%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLT---ADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RVRYN Q Y  VF  D  A+  + NS  + SL  L++RWLERTPG  +   NFW  +  +V R+L    E Q+    E P +K       D EK ++ Y +I D   ++ L++RG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + ++L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYN-QKYSDVF-SDEEARNSIRNSEKDPSLLELVQRWLERTPGLEETGFNFWAKFQESVDRFL----EAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKL 374
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Match: sp|B4IDV8|T23O_DROSE (Tryptophan 2,3-dioxygenase OS=Drosophila sechellia OX=7238 GN=v PE=3 SV=1)

HSP 1 Score: 352.058 bits (902), Expect = 9.623e-118
Identity = 182/318 (57.23%), Postives = 227/318 (71.38%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLT---ADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RVRYN Q Y  VF  D  A+  + NS  + SL  L++RWLERTPG  +   NFW  +  +V R+L    E Q+    E P +K       D EK ++ Y +I D   ++ L++RG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + ++L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYN-QKYSDVF-SDEEARNSIRNSEKDPSLLELVQRWLERTPGLEETGFNFWAKFQESVDRFL----EAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKKL 374
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Match: sp|B4L629|T23O_DROMO (Tryptophan 2,3-dioxygenase OS=Drosophila mojavensis OX=7230 GN=v PE=3 SV=1)

HSP 1 Score: 351.673 bits (901), Expect = 1.249e-117
Identity = 179/315 (56.83%), Postives = 225/315 (71.43%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGS-KLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFKQIIFE DSI++M    V+DE     I+ RL RVVLILK LVDQ+ ILETMT +DFMDFR +L  ASGFQSLQFRL+ENKLGV  E RV+YN Q Y  VF  D  A   + +S D  SL  L++RWLERTPG  +   NFW  +  +V ++L    +  + +  E  +   L  D EK ++ Y +I D   ++ L+KRG++RFS+ A +GA+MI+ YRDE RFSQP+Q+L+L++DID+ +TKWRYNHVIMVQRMIGS +LGTGGSSGYQYLRST+SDRY  F DL NLST+LIPRE IP L   + R+L
Sbjct:   63 AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVKYN-QKYTDVFGNDKKALHAIRDSEDSPSLLTLVQRWLERTPGLEEDGFNFWAKFQQSVDQFLAAQVQSAMLEPVERAKNYRLM-DIEKRREVYRSIFDPAVHDALVKRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRRKL 375
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Match: Q4G1M4 (Tryptophan 2,3-dioxygenase OS=Azumapecten farreri OX=106299 GN=TDO PE=2 SV=1)

HSP 1 Score: 387.111 bits (993), Expect = 5.016e-129
Identity = 187/318 (58.81%), Postives = 246/318 (77.36%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPE-KKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQM 1207
             YELWFKQI+FE+DS++E+F   V+DE   R I NRL+R+ LILK LVDQ  ILETMT +DF++FR HL  ASGFQSLQFRL+ENKLG+ E+SRV+YN+Q+Y  VF  DP     +++S+   SL  L+ERWLERTPG   A+ +FWE Y  AV R+L+D +  Q  K +  PE K+ L A+Y+K+K S++T+ D   + + ++RGE+R S+ AF+GALMISLYRDE+RF+QP+ +L+L++DID+ +TKWRYNHV+MVQRMIGSK+GTGGSSGY YLRST+SDRY  F DL NLST+LIPR+YIP L++ M R LS +
Sbjct:   50 AYELWFKQILFELDSVREIFTAPVLDEGKARHINNRLSRITLILKLLVDQFLILETMTPLDFLEFRTHLATASGFQSLQFRLIENKLGLKEDSRVKYNQQHYMEVF-NDPENIAMLQDSISSPSLLTLVERWLERTPGLAKAEFHFWERYQSAVNRWLEDQWY-QPVKNESNPEVKETLMAEYQKQKDSFDTVFDPEKHQKSMERGERRLSHKAFQGALMISLYRDESRFNQPFHLLTLLVDIDSLMTKWRYNHVMMVQRMIGSKVGTGGSSGYHYLRSTISDRYKVFLDLFNLSTFLIPRDYIPPLTTTMKRTLSSV 365
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Match: A0A0Y0I213 (Tryptophan-2,3-dioxygenase (Fragment) OS=Leptochiton asellus OX=211853 PE=2 SV=1)

HSP 1 Score: 388.267 bits (996), Expect = 6.793e-129
Identity = 182/315 (57.78%), Postives = 244/315 (77.46%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLS 1201
             YELWFKQI++EIDS++EMF    +DE     +IN+L RVVLI+K LVDQ  ILETMT +DF+DFRG L  +SGFQSLQFRLLENKLG+  E+RV+YN+++Y  VF KDP + ++++NSL   SL  L++RWLERTPG   +  +FW+ +  A   +L +   +  ++L++G EK+ + A+Y+K+K ++E+I DE  Y   ++RGE+RF+Y AF+GA+MISLYR E RF+QP+Q+L+L++D+D+ LTKWRYNHV+MVQRM+GSK+GTGGSSGYQYLRST+SDRY  F DL NLST+LIPR YIP L   M RRLS
Sbjct:   60 TYELWFKQILYEIDSVREMFTNTSLDETKTLQMINQLNRVVLIMKLLVDQFHILETMTPLDFIDFRGRLSTSSGFQSLQFRLLENKLGILPENRVKYNQEHYCQVF-KDPESLQQIDNSLKCPSLLNLVQRWLERTPGLETSGFDFWDKFSTAANEWLSNTLLEPASELEDGKEKETMMAEYQKQKDTFESIFDEQKYQIYVERGERRFTYRAFQGAMMISLYRHEPRFNQPFQLLTLLMDVDSLLTKWRYNHVLMVQRMLGSKVGTGGSSGYQYLRSTISDRYKVFLDLFNLSTFLIPRNYIPSLDYTMKRRLS 373
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Match: A0A2C9JIK0 (Tryptophan 2,3-dioxygenase OS=Biomphalaria glabrata OX=6526 GN=106056678 PE=3 SV=1)

HSP 1 Score: 381.333 bits (978), Expect = 4.632e-126
Identity = 186/315 (59.05%), Postives = 241/315 (76.51%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLS 1201
             YELWFKQI++EIDS++ MF   V++E    +I+NRL+RV LILK LVDQ+ ILETMT +DF++FR  L +ASGFQSLQFRLLENK+GV E SRV+YN+Q+Y  VF K P   + +E+SL++ SL  LLE+WLERTPG      NFWE Y  +V R+L+D  +       +   K+ L  +Y+K+K+S+E+I DE  YN  + RG++R S+ AFKGAL+ISLY D+ RF+QP ++LSL++DID+ +TKWRYNHV+MVQRMIGSK+GTGGSSGYQYLRSTVSDRY  F DL N+STYLIPR+YIP LS  + R+LS
Sbjct:   70 AYELWFKQILYEIDSVRNMFMLPVLEETKTLLILNRLSRVALILKLLVDQVDILETMTPLDFLEFRLQLSSASGFQSLQFRLLENKIGVLESSRVKYNQQHYAKVFSK-PEQVKMLEDSLEQPSLFQLLEKWLERTPGLAVKSFNFWELYKRSVDRWLQDMLQQSAQNETDESVKQSLIEEYKKQKESFESILDEEKYNAAVARGDRRMSHLAFKGALLISLYHDQPRFNQPSKLLSLLMDIDSLMTKWRYNHVMMVQRMIGSKVGTGGSSGYQYLRSTVSDRYKVFLDLFNMSTYLIPRDYIPPLSRSLKRQLS 383
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Match: A0A210PL53 (Tryptophan 2,3-dioxygenase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT12391 PE=3 SV=1)

HSP 1 Score: 379.022 bits (972), Expect = 8.401e-126
Identity = 181/317 (57.10%), Postives = 241/317 (76.03%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQM 1207
             YELWFKQI+FE+DS++E+F   V+DE   R I NRL+R+ LILK LVDQ  ILETMT +DF++FR  L  ASGFQSLQFRL+ENK+G+ E+SRV+YN+Q+Y  VF  DP     +++S+   SL  L+ERWLERTPG   A+ +FWE Y  AV R+L+D +   +    +   K+ L A+Y+K+K S++T+ D   + + ++RGE+R S+ AF+GALMISLYRDE+RF+QP+ +L+L++DID+ +TKWRYNHV+MVQRMIGSK+GTGGSSGY YLRST+SDRY  F DL NLST+LIPR+YIP L+  M R LS +
Sbjct:   50 AYELWFKQILFELDSVREIFTVPVLDEGKARHINNRLSRITLILKLLVDQFLILETMTPLDFLEFRTRLATASGFQSLQFRLIENKIGLKEDSRVKYNQQHYMKVF-NDPENIAMLQDSISSPSLLTLVERWLERTPGLAKAEFHFWERYQCAVNRWLEDQWYKPVKDENDPEVKETLMAEYQKQKDSFDTVFDPEKHQKSMERGERRLSHKAFQGALMISLYRDESRFNQPFHLLTLLVDIDSLMTKWRYNHVMMVQRMIGSKVGTGGSSGYHYLRSTISDRYKVFLDLFNLSTFLIPRDYIPPLTITMKRTLSSV 365
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Match: R7VAT5 (Tryptophan 2,3-dioxygenase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_225408 PE=3 SV=1)

HSP 1 Score: 378.252 bits (970), Expect = 2.552e-125
Identity = 192/328 (58.54%), Postives = 247/328 (75.30%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQI-VMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCY-----EDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDFSYN 1222
             YELWFKQI+FEIDS++++F +  VMDE    +II+R+ RVV+ILK L DQ  ILETMT +DFMDFRG L  ASGFQSLQFRLLENKLGV +ESRV+YN+Q+YKSVF  D  + E ++ S+D+ SL  ++E WLERTPG  D    FW  Y  A + ++++ Y     E+Q  KL+E  EK    ADY K+ ++Y+++ D + YN  + RG++RFS+ AF+GA+MISLYRDE RF QP+Q+L+L++D+D+ LTKWRYNHV+MVQRMIGSK+GTGGSSGYQYLRSTV DRY  F DL NLST+LIPREYIP L+  M +RLS  +   N
Sbjct:   68 AYELWFKQILFEIDSVRKLFMEAPVMDESKTLLIISRMNRVVIILKLLADQFHILETMTPLDFMDFRGFLDPASGFQSLQFRLLENKLGVRQESRVKYNQQHYKSVFH-DSKSYEMIDKSIDDPSLLDVVECWLERTPGL-DVGFGFWGKYMRAAKTWIENGYLQPAREEQDPKLRE--EK---MADYRKQMETYDSVADIDVYNTHVARGDRRFSHMAFQGAMMISLYRDEPRFHQPFQILTLLMDLDSLLTKWRYNHVMMVQRMIGSKVGTGGSSGYQYLRSTVGDRYKVFLDLFNLSTFLIPREYIPPLTPHMKQRLSIFEVRIN 388
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Cavefish
Match: tdo2a (tryptophan 2,3-dioxygenase A [Source:NCBI gene;Acc:103034668])

HSP 1 Score: 320.857 bits (821), Expect = 3.353e-106
Identity = 160/311 (51.45%), Postives = 221/311 (71.06%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKL---LTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLS 1177
             YELWFKQI++E+DS++E+F    V DERNM  +  R+ R+V+I + LVDQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+ +F    I  E +  S  E +L  L+E+WLERTPG  +   +FW    + +   L+   E    K+++ PE ++   + AD+ K+K+ + ++ DE  ++ L  +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RMIGSK GTGGSSGYQYLRSTVSDRY  F DL NL+T+L+PR++IPKL+
Sbjct:   77 AYELWFKQILWELDSVREIFISGHVRDERNMLKVNTRIHRIVMIFRLLVDQFAVLETMTALDFFDFREYLSPASGFQSLQFRLLENKIGVPDNQRVPYNRRHYRDIFRGQEI--ELLLRSEQEATLLQLVEKWLERTPGLEEDGFSFWGKLEVNIFEGLRREKE----KIEQQPESEMKEEMMADFIKQKEIFVSLFDEKRHDHLQSKGERRLSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKAGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLVPRDWIPKLN 381
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Cavefish
Match: tdo2b (tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc:334082])

HSP 1 Score: 303.138 bits (775), Expect = 1.684e-99
Identity = 147/308 (47.73%), Postives = 211/308 (68.51%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLS 1177
             YELWFKQI++E+DS++++F    V DERNM  +++R+ R+ +I + LVDQ ++LETMTA+DF DFR +L +ASGFQSLQFRLLENK+GV+E  RV YN+++Y+  F       + +  +  E +L  L+E+WLERTPG  +   NFW    + V    ++ +  +  KL+          D  K+ + + ++ D   ++ L+ +GE+R SY A +GALMI  YR+E RF  P+Q+L+ ++++D  +TKWRYNHV M  RMIGSK GTGGSSGY YLRSTVSDRY  F DL NL+T+LIPR ++PK++
Sbjct:   73 AYELWFKQILWELDSVRKIFIHNHVRDERNMLTVVSRIHRITMIFRLLVDQFAVLETMTALDFYDFREYLSSASGFQSLQFRLLENKIGVAENLRVPYNRRHYRDNFHGQE--SQALLQTEQERTLLQLVEQWLERTPGLEEDGFNFWGKLQVNV----EEGFRSEKQKLE----------DLSKQIELFNSLFDSKRHDHLLSKGERRLSYKALQGALMIYFYREEPRFQVPFQLLTNLMEVDVLMTKWRYNHVCMAHRMIGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLATFLIPRAWVPKVN 364
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Sea Lamprey
Match: tdo2b (tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc:334082])

HSP 1 Score: 314.694 bits (805), Expect = 1.721e-104
Identity = 161/328 (49.09%), Postives = 228/328 (69.51%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPE-KKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQM---DFSYNS 1225
             YELWFKQI++E+DSI+++F  + + +ERNM  +++R+ R+ LI   LVDQ S++ETMT +DF DFR +L  ASGFQSLQFR+LENK+GV +  RV YNK++++  F  +   K R+  S  E +L  L++ WLERTPG      NFWE    +V   L++  E   AKL E    K+ L  +  K+++++ ++ DE  +  L+ +G +R SY A +GALMI  YR+E RF  P+Q+L+ ++D+D+ +TKWRYNHV +VQRMIGSK GTGGSSGYQYLRSTVSDRY  F DL NL+T+L+PR +IP+L+  + R L++    D SY+S
Sbjct:   75 AYELWFKQILWELDSIRQIFYHRQIKNERNMLKVVSRMHRITLIFHLLVDQFSVMETMTPLDFFDFRHYLAPASGFQSLQFRMLENKIGVPDSLRVPYNKRHFRDSFRGEEFEKLRL--SEIEPTLLQLVQEWLERTPGLEVGGFNFWEKLKKSVSERLEE--EACKAKLMENATLKEELMNEIRKQQETFGSLFDEKRHIHLMSKGTRRLSYKALQGALMIYFYREEPRFQVPFQLLNSLMDLDSLMTKWRYNHVCLVQRMIGSKAGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLVPRSWIPRLTPMLHRSLAKASCCDSSYSS 398
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Nematostella
Match: EDO49705 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFF0])

HSP 1 Score: 318.931 bits (816), Expect = 2.912e-106
Identity = 167/318 (52.52%), Postives = 219/318 (68.87%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNY-KSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEK---KSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRL 1198
             YELWFK+II EID+++ MF +   +E     +I+ L RVV ILK L DQI +LETMT + FM+FR +L  ASGFQS QFRL+ENKLGV   SR     Q Y K + EKD    E+VE +  E+SLQ L++RWL RTPG      NFW  Y  +V  ++ D      A+ +  P K L +   +  K   +++ETI  E  +N+L+ RGE++FS+ A +GALMIS YRDE RF+QPYQ+L+L++DID+ L KWRYNHV++VQRM+GSK GTGGSSGYQYLRST+SDRY  F DL N+S +L+PR+ IP L+S+M  RL
Sbjct:   64 AYELWFKEIIHEIDTVRSMFMEEDFNESKTLFVISCLHRVVAILKLLKDQILLLETMTPLGFMEFRNYLAPASGFQSQQFRLIENKLGVRRASRFCLANQEYSKQLREKDV---EQVEQAESEDSLQELVQRWLCRTPGLETDGFNFWGKYKRSVHAWMVDLK----AEAENAPSKALKSERLKTLKGTVETFETIFSEERHNQLVARGERKFSHKALQGALMISFYRDEPRFNQPYQILNLLMDIDSLLIKWRYNHVLIVQRMLGSKAGTGGSSGYQYLRSTISDRYKVFLDLFNMSNFLVPRDRIPPLTSDMKMRL 374
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Medaka
Match: tdo2a (tryptophan 2,3-dioxygenase [Source:NCBI gene;Acc:101169427])

HSP 1 Score: 324.709 bits (831), Expect = 7.549e-107
Identity = 160/311 (51.45%), Postives = 219/311 (70.42%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMF-QQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEM 1186
             YELWFKQI+FE+DS++E+F    V DERNM  +  R+ R+V+I + LVDQ ++LETMTA+DF DFR +L  ASGFQSLQFRLLENK+GV +  RV YN+++Y+  F+      E + ++  E +L  L+E WLERTPG      NFWE   + +   L      +  K+ +G EK+   A+  K+++ + ++ DE H++ L+ +GE+RFSY A +GALMI  YR+E RF  P+Q+L+ ++DID  +TKWRYNHV MV RMIGSK GTGGSSGYQYLRSTVSDRY  F DL NL+T+L+PR ++PKL+  +
Sbjct:  140 AYELWFKQILFELDSVREIFVSGHVRDERNMLKVNTRIHRIVMIFRLLVDQFAVLETMTALDFFDFREYLTPASGFQSLQFRLLENKIGVPDNLRVPYNRRHYRDNFKGQ--QSEMLLSAEQEPTLLKLVEAWLERTPGLEVDGFNFWEKLRINIYEGLSK-ERQKTEKMADGEEKEDRKAEQAKQREIFTSLFDEKHHDHLVSKGERRFSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKAGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLVPRHWVPKLNPNV 447
[Close]
BLAST of Tryptophan-2,3-dioxygenase vs. Planmine SMEST
Match: SMESG000075109.1 (SMESG000075109.1)

HSP 1 Score: 669.848 bits (1727), Expect = 0.000e+0
Identity = 323/323 (100.00%), Postives = 323/323 (100.00%), Query Frame = 2 
Query:  257 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDFSYNS 1225
            VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDFSYNS
Sbjct:   70 VYELWFKQIIFEIDSIKEMFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGHLQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVENSLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAKLQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGALMISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTGGSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMDFSYNS 392

HSP 2 Score: 140.969 bits (354), Expect = 1.813e-37
Identity = 68/69 (98.55%), Postives = 69/69 (100.00%), Query Frame = 3 
Query:    9 LENIEIEKSESSGCTFNRQSSKFSLHSINEKQSLTYSSYLNLDKLLSCQTLIECGKYTHDQLLFQITHQ 215
            +ENIEIEKSESSGCTFNRQSSKFSLHSINEKQSLTYSSYLNLDKLLSCQTLIECGKYTHDQLLFQITHQ
Sbjct:    1 MENIEIEKSESSGCTFNRQSSKFSLHSINEKQSLTYSSYLNLDKLLSCQTLIECGKYTHDQLLFQITHQ 69
The following BLAST results are available for this feature:
BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TDO24.528e-10451.56tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc... [more]
TDO24.528e-10451.56tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc... [more]
TDO21.278e-1966.13tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc... [more]
TDO21.278e-1966.13tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc... [more]
TDO24.159e-1265.22tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tdo-28.792e-10950.15Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swis... [more]
tdo-28.792e-10950.15Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swis... [more]
tdo-23.619e-4468.69Tryptophan 2,3-dioxygenase [Source:UniProtKB/Swis... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
v7.237e-11957.23gene:FBgn0003965 transcript:FBtr0073386[more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
tdo2b1.223e-10448.01tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc... [more]
tdo2a2.662e-10050.32tryptophan 2,3-dioxygenase a [Source:NCBI gene;Acc... [more]
tdo2a2.662e-10050.32tryptophan 2,3-dioxygenase a [Source:NCBI gene;Acc... [more]
tdo2b1.167e-3554.55tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tdo24.639e-10651.57tryptophan 2,3-dioxygenase [Source:NCBI gene;Acc:5... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Tdo21.420e-10452.27tryptophan 2,3-dioxygenase [Source:MGI Symbol;Acc:... [more]
Tdo22.397e-10452.27tryptophan 2,3-dioxygenase [Source:MGI Symbol;Acc:... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|B3MQP7|T23O_DROAN7.570e-11957.23Tryptophan 2,3-dioxygenase OS=Drosophila ananassae... [more]
sp|P20351|T23O_DROME7.254e-11857.23Tryptophan 2,3-dioxygenase OS=Drosophila melanogas... [more]
sp|Q24630|T23O_DROSI9.623e-11857.23Tryptophan 2,3-dioxygenase OS=Drosophila simulans ... [more]
sp|B4IDV8|T23O_DROSE9.623e-11857.23Tryptophan 2,3-dioxygenase OS=Drosophila sechellia... [more]
sp|B4L629|T23O_DROMO1.249e-11756.83Tryptophan 2,3-dioxygenase OS=Drosophila mojavensi... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q4G1M45.016e-12958.81Tryptophan 2,3-dioxygenase OS=Azumapecten farreri ... [more]
A0A0Y0I2136.793e-12957.78Tryptophan-2,3-dioxygenase (Fragment) OS=Leptochit... [more]
A0A2C9JIK04.632e-12659.05Tryptophan 2,3-dioxygenase OS=Biomphalaria glabrat... [more]
A0A210PL538.401e-12657.10Tryptophan 2,3-dioxygenase OS=Mizuhopecten yessoen... [more]
R7VAT52.552e-12558.54Tryptophan 2,3-dioxygenase OS=Capitella teleta OX=... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tdo2a3.353e-10651.45tryptophan 2,3-dioxygenase A [Source:NCBI gene;Acc... [more]
tdo2b1.684e-9947.73tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tdo2b1.721e-10449.09tryptophan 2,3-dioxygenase b [Source:NCBI gene;Acc... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO497052.912e-10652.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tdo2a7.549e-10751.45tryptophan 2,3-dioxygenase [Source:NCBI gene;Acc:1... [more]
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BLAST of Tryptophan-2,3-dioxygenase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000075109.11.813e-37100.00SMESG000075109.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007277 ID=SMED30007277|Name=Tryptophan-2,3-dioxygenase|organism=Schmidtea mediterranea sexual|type=transcript|length=1298bp
CTTCCGATCTGGAAAATATTGAAATAGAAAAAAGTGAAAGCAGTGGTTGC
ACTTTTAATAGACAATCAAGTAAATTTTCACTACACTCGATTAATGAAAA
GCAAAGTCTTACATACTCTTCGTATTTAAATTTAGATAAATTGTTGTCCT
GCCAAACGCTAATAGAATGCGGTAAATATACTCATGATCAACTGCTTTTT
CAGATAACTCATCAAGGTAATTTATAAAAAAATAGGTTAAACATAAATTT
CTCTAAGTCTATGAGCTTTGGTTCAAGCAAATAATTTTTGAAATTGATTC
AATAAAAGAAATGTTTCAGCAAATTGTTATGGATGAAAGAAATATGCGAG
TGATTATTAATCGACTTACTAGAGTTGTTTTAATACTCAAAACATTGGTA
GATCAGATCAGTATACTAGAAACAATGACGGCGATAGATTTTATGGACTT
TAGAGGACATTTACAAGCTGCCTCAGGATTTCAGAGCCTCCAATTTCGTT
TATTGGAAAATAAACTTGGAGTTTCGGAAGAGTCACGAGTTAGATACAAC
AAGCAAAATTATAAATCAGTATTTGAAAAGGACCCAATAGCTAAAGAAAG
AGTTGAAAATTCTCTTGATGAAGAATCTTTGCAAGTACTATTAGAGAGGT
GGCTCGAAAGAACGCCTGGTTGCAATGATGCTGATTCGAATTTTTGGGAA
AGTTATTGTCTAGCAGTGAGAAGATATCTGAAAGATTGTTATGAGGATCA
AATTGCAAAATTGCAAGAAGGTCCTGAAAAGAAATTATTAACAGCTGATT
ATGAAAAAGAAAAAAAATCTTATGAGACAATAACAGATGAAAATCATTAC
AACGAACTTATAAAGAGAGGTGAAAAACGATTCTCTTACAACGCTTTCAA
AGGTGCCTTGATGATTTCTCTGTACAGGGATGAGACTCGGTTTTCACAGC
CGTATCAAATGTTGAGTCTTATTTTAGATATAGATGCATTTCTAACTAAA
TGGAGATATAATCACGTTATAATGGTGCAGCGTATGATTGGTAGTAAGCT
TGGAACCGGTGGATCATCTGGATATCAATATTTAAGGTCCACTGTAAGCG
ATCGGTACATGCCATTCTGTGACCTATGCAACTTGTCGACATACTTGATT
CCAAGAGAATACATTCCAAAGCTCAGTTCGGAAATGCTTCGACGACTGAG
CCAAATGGATTTTAGTTATAATAGTTAAATTTAAGTTAGAAACTTCGGTG
GAAAGTTTATTGGAATTTATTTTAAATAAATATATAGTCTTAAAAAAA
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protein sequence of SMED30007277-orf-1

>SMED30007277-orf-1 ID=SMED30007277-orf-1|Name=SMED30007277-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=306bp
MFQQIVMDERNMRVIINRLTRVVLILKTLVDQISILETMTAIDFMDFRGH
LQAASGFQSLQFRLLENKLGVSEESRVRYNKQNYKSVFEKDPIAKERVEN
SLDEESLQVLLERWLERTPGCNDADSNFWESYCLAVRRYLKDCYEDQIAK
LQEGPEKKLLTADYEKEKKSYETITDENHYNELIKRGEKRFSYNAFKGAL
MISLYRDETRFSQPYQMLSLILDIDAFLTKWRYNHVIMVQRMIGSKLGTG
GSSGYQYLRSTVSDRYMPFCDLCNLSTYLIPREYIPKLSSEMLRRLSQMD
FSYNS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0020037heme binding
GO:0004833tryptophan 2,3-dioxygenase activity
GO:0051213dioxygenase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000067goblet cell
PLANA:0002075pigment cell
Vocabulary: INTERPRO
TermDefinition
IPR037217Trp/Indoleamine_2_3_dOase-like
IPR004981Trp_2_3_dOase
Vocabulary: biological process
TermDefinition
GO:0019441tryptophan catabolic process to kynurenine
GO:0055114oxidation-reduction process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR004981Tryptophan 2,3-dioxygenasePFAMPF03301Trp_dioxygenasecoord: 3..279
e-value: 4.1E-101
score: 338.8
IPR004981Tryptophan 2,3-dioxygenasePANTHERPTHR10138TRYPTOPHAN 2,3-DIOXYGENASEcoord: 1..298
IPR037217Tryptophan/Indoleamine 2,3-dioxygenase-likeSUPERFAMILYSSF140959Indolic compounds 2,3-dioxygenase-likecoord: 6..279