serine/threonine-protein kinase DCLK1

Overview
Nameserine/threonine-protein kinase DCLK1
Smed IDSMED30007209
Length (bp)1381
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of serine/threonine-protein kinase DCLK1 (SMED30007209) t-SNE clustered cells

Violin plots show distribution of expression levels for serine/threonine-protein kinase DCLK1 (SMED30007209) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of serine/threonine-protein kinase DCLK1 (SMED30007209) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for serine/threonine-protein kinase DCLK1 (SMED30007209) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007209

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000050790.1 dd_Smed_v4_11772_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v4_3128_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v4_3128_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v4_3128_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v4_3128_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000050790.1 dd_Smed_v6_11772_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v6_3128_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000050790.1 dd_Smed_v4_11772_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30007209SMESG000078466.1 SMESG000050786.1 SMESG000024968.1 dd_Smed_v4_3128_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Match: DCLK3 (doublecortin like kinase 3 [Source:HGNC Symbol;Acc:HGNC:19005])

HSP 1 Score: 357.066 bits (915), Expect = 1.489e-116
Identity = 172/322 (53.42%), Postives = 224/322 (69.57%), Query Frame = 3 
Query:  153 QVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQ 1118
            Q   ++ E  T  E++  ++   RKP   G I              + + +E  +++GDGNFAVVK   HR+T+  YA+KIIDKSR+ GKE M+++EI I++  +H NIVKL E YET  E++L++E V+ GDLFDAI ++VKF EP AA M+ D+  AL ++H + IVHRDLKPENL+V R++D S TLKLADFGLA  + + I+TVCGTPTYVAPEILSEKGY LEVD+WA GVI YILLCGFPPFRS  R+Q+ELF IIQ G+FEF+ PYWD IS   KDL+ +LLVVD K R +   VL H W+   GK + +  + Q
Sbjct:  317 QPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAAN-----------VEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQ 627
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Match: DCLK3 (doublecortin like kinase 3 [Source:HGNC Symbol;Acc:HGNC:19005])

HSP 1 Score: 356.295 bits (913), Expect = 2.220e-114
Identity = 172/322 (53.42%), Postives = 224/322 (69.57%), Query Frame = 3 
Query:  153 QVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQ 1118
            Q   ++ E  T  E++  ++   RKP   G I              + + +E  +++GDGNFAVVK   HR+T+  YA+KIIDKSR+ GKE M+++EI I++  +H NIVKL E YET  E++L++E V+ GDLFDAI ++VKF EP AA M+ D+  AL ++H + IVHRDLKPENL+V R++D S TLKLADFGLA  + + I+TVCGTPTYVAPEILSEKGY LEVD+WA GVI YILLCGFPPFRS  R+Q+ELF IIQ G+FEF+ PYWD IS   KDL+ +LLVVD K R +   VL H W+   GK + +  + Q
Sbjct:  486 QPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAAN-----------VEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQ 796
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Match: DCLK1 (doublecortin like kinase 1 [Source:HGNC Symbol;Acc:HGNC:2700])

HSP 1 Score: 316.62 bits (810), Expect = 1.675e-103
Identity = 151/266 (56.77%), Postives = 191/266 (71.80%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFAVVK  + R T  EYALKII KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A+ M+ ++A+A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G  +F SPYWD +S   K+LI  +L+VD   R S + VL H W+   G
Sbjct:   79 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDG 344
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Match: DCLK2 (doublecortin like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19002])

HSP 1 Score: 324.324 bits (830), Expect = 2.246e-103
Identity = 152/276 (55.07%), Postives = 200/276 (72.46%), Query Frame = 3 
Query:  249 VMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            V G  C   S S  + +++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ I++   H NI+ L EE ET  E+FLVMELVK GDLFDAIT + K++E   + MV ++ANAL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I +G  EF +PYWD I+   K+LI ++L V+ + R +   +LSH W+
Sbjct:  378 VNGNRC---SESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWV 650
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Match: DCLK2 (doublecortin like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19002])

HSP 1 Score: 324.709 bits (831), Expect = 3.253e-103
Identity = 152/276 (55.07%), Postives = 200/276 (72.46%), Query Frame = 3 
Query:  249 VMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            V G  C   S S  + +++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ I++   H NI+ L EE ET  E+FLVMELVK GDLFDAIT + K++E   + MV ++ANAL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I +G  EF +PYWD I+   K+LI ++L V+ + R +   +LSH W+
Sbjct:  395 VNGNRC---SESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWV 667
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Match: cmk-1 (Calcium/calmodulin-dependent protein kinase type 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TXJ0])

HSP 1 Score: 221.861 bits (564), Expect = 3.143e-68
Identity = 110/264 (41.67%), Postives = 165/264 (62.50%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTE-YALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA-MEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            I ++++   +LG G F+ V LA  +    + YA+K IDK  + GKE  +ENEI +++   H+NIV+L + Y+ ++ V+LVMELV  G+LFD I     ++E  A+ ++  +  A+ ++H   +VHRDLKPENL+     + S  + ++DFGL+  E   ++ T CGTP YVAPE+L +K Y   VD+W++GVI YILLCG+PPF   + +   LF  I  G +EF +PYWD+IS   KD I  L+  D + R +  D LSH W+
Sbjct:   18 IREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDS-KIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFY--DESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWI 278
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Match: zyg-8 (Serine/threonine-protein kinase zyg-8 [Source:UniProtKB/Swiss-Prot;Acc:Q95QC4])

HSP 1 Score: 225.713 bits (574), Expect = 1.131e-66
Identity = 118/314 (37.58%), Postives = 196/314 (62.42%), Query Frame = 3 
Query:  297 QRFEVTKMLGDGNFAVVKLALHRKTKTEY-ALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKK---LIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQRVLELEDLAKENLESFQRHKKELRTSINREIQAA 1226
            ++F++ +++GDGN AVV   + +    +  A+K+I +  ++GKE +IE E+ I++  +H  IV+L + +   +  +L +EL++ GDLF+ +    +  E  A +M+  +  AL Y+H   IVHRD+K ENL++++ + G + +KLADFGLA E+ K   ++ T+CGTPTYVAPE+L++ GY  +VD+WA GVI Y +L GFPPF+SS+ ++++LF  I SG F F SP WD +SW V+ LI  L+  D   R S  ++L+ +W++  G V     E    R ++ +   +E  E+   +    RTS++   ++A
Sbjct:  327 EKFQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLRIVRRVPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGCKVDIWAAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWMVNLGDVDP-EYEEWAHRFVQSKMHVEEEQETPYEYYTSRRTSMDELSESA 639
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Match: zyg-8 (Serine/threonine-protein kinase zyg-8 [Source:UniProtKB/Swiss-Prot;Acc:Q95QC4])

HSP 1 Score: 226.098 bits (575), Expect = 9.388e-66
Identity = 118/317 (37.22%), Postives = 198/317 (62.46%), Query Frame = 3 
Query:  288 IIYQRFEVTKMLGDGNFAVVKLALHRKTKTEY-ALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKK---LIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQRVLELEDLAKENLESFQRHKKELRTSINREIQAA 1226
            ++ ++F++ +++GDGN AVV   + +    +  A+K+I +  ++GKE +IE E+ I++  +H  IV+L + +   +  +L +EL++ GDLF+ +    +  E  A +M+  +  AL Y+H   IVHRD+K ENL++++ + G + +KLADFGLA E+ K   ++ T+CGTPTYVAPE+L++ GY  +VD+WA GVI Y +L GFPPF+SS+ ++++LF  I SG F F SP WD +SW V+ LI  L+  D   R S  ++L+ +W++  G V     E    R ++ +   +E  E+   +    RTS++   ++A
Sbjct:  477 LLDEKFQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLRIVRRVPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGCKVDIWAAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWMVNLGDVDP-EYEEWAHRFVQSKMHVEEEQETPYEYYTSRRTSMDELSESA 792
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Match: F32D8.1 (pep chromosome:WBcel235:V:10880837:10883399:1 gene:WBGene00009326.1 transcript:F32D8.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F32D8.1)

HSP 1 Score: 213.386 bits (542), Expect = 2.882e-65
Identity = 102/279 (36.56%), Postives = 167/279 (59.86%), Query Frame = 3 
Query:  240 GSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            G   + K  +++     I +++E+  ++G GNF+ V L   ++  T+ ALK ++K  M GK   ++NE+ ++ L  HD+I+ + + + T  + F+V E  + GDL++ I +N +  EP AA +   +A+AL YLH R +VHRD+KPENL+++       ++KL DFGLA  I   +Y +CGTPTY APE+L E GYS   D+W+LGV+ Y++L G+ PFR+   +Q  LF++I         P W  IS + KDL+ +L+    + R     +++H W+
Sbjct:   50 GFFGVSKWIQRVDGRQDIEKQYEIGAIIGKGNFSSVHLTRRKEDGTKCALKQVEKRAMRGKCFFVDNEVEMLSLIQHDHIISIIDAFSTENQYFIVFEHAQYGDLYETIRKNGRIEEPDAAIITLQVASALNYLHERNVVHRDVKPENLLLV----DKFSVKLCDFGLACHILGPLYRICGTPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVGYAPFRAP--DQTRLFKLIMQAKPNLDMPEWKGISLKAKDLVSRLMNKTEERRPLASQIMAHPWI 322
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305])

HSP 1 Score: 190.274 bits (482), Expect = 1.017e-56
Identity = 101/278 (36.33%), Postives = 163/278 (58.63%), Query Frame = 3 
Query:  273 LSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKE-SMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIK--KLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVS 1097
            +++S      ++V + LG G F+VV+  +H+ T  E+A KII+  ++  ++   +E E  I +   H NIV+L +  +     +LV +LV  G+LF+ I     +SE  A+  +  +  ++ Y HS  IVHRDLKPENL++     G+  +KLADFGLA+E+   +  +   GTP Y++PE+L +  YS  VD+WA GVI YILL G+PPF   + +Q  L+  I++G +++ SP WD ++ E K LI  +L V+ K R +    L   W+  + +V+
Sbjct:    2 MNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGA-AVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFW--DEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVA 276
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Match: CG17528 (gene:FBgn0261387 transcript:FBtr0111274)

HSP 1 Score: 275.789 bits (704), Expect = 1.402e-84
Identity = 132/265 (49.81%), Postives = 176/265 (66.42%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSI-TLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMA 1082
            I   + + +++GDGNFA+V    HR+T   YALKIIDK++  GKE  I+ E+ +MK  NH +I+ L    +    ++LV+E V  GDLFDAITQ  +FSE  +  M+  +  A+ YLHS  IVHRD+KPENL+V   + G++  LKLADFGLA E+  L+Y VCGTPTYVAPEIL E GY L++D+WA G+I YILLCGFPPF + +  QE LF  I SG +EF  PYW  I   V+DLI  +L  D  +R ++ D+L H W + 
Sbjct:  473 IRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIG 737
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Match: CG17528 (gene:FBgn0261387 transcript:FBtr0111277)

HSP 1 Score: 275.789 bits (704), Expect = 1.402e-84
Identity = 132/265 (49.81%), Postives = 176/265 (66.42%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSI-TLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMA 1082
            I   + + +++GDGNFA+V    HR+T   YALKIIDK++  GKE  I+ E+ +MK  NH +I+ L    +    ++LV+E V  GDLFDAITQ  +FSE  +  M+  +  A+ YLHS  IVHRD+KPENL+V   + G++  LKLADFGLA E+  L+Y VCGTPTYVAPEIL E GY L++D+WA G+I YILLCGFPPF + +  QE LF  I SG +EF  PYW  I   V+DLI  +L  D  +R ++ D+L H W + 
Sbjct:  473 IRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIG 737
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Match: CaMKI (gene:FBgn0016126 transcript:FBtr0333670)

HSP 1 Score: 236.498 bits (602), Expect = 2.418e-73
Identity = 120/281 (42.70%), Postives = 177/281 (62.99%), Query Frame = 3 
Query:  240 GSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTE-YALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA-MEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            G     K  ++L+    I +++ +  +LG G F+ V+LA  + +  E +A+KIIDK  + GKE  +ENEI +++   H NIV+L E YE + +V+LVMELV  G+LFD I +   ++E  A+ ++  +  A+ Y+H + +VHRDLKPENL+     D S  + ++DFGL+ ME   ++ T CGTP YVAPE+L++K Y   VD+W++GVI+YILLCG+PPF   + N   LF  I  G+FEF SPYWD+IS   K  IK L+ V  + R +    L H W+
Sbjct:   10 GKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDS-KIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFY--DENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWI 287
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Match: CaMKI (gene:FBgn0016126 transcript:FBtr0089067)

HSP 1 Score: 226.483 bits (576), Expect = 2.745e-69
Identity = 121/296 (40.88%), Postives = 178/296 (60.14%), Query Frame = 3 
Query:  240 GSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTE-YALKIIDKSRMMGKESMIENEIWIMKL---------C------NHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA-MEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            G     K  ++L+    I +++ +  +LG G F+ V+LA  + +  E +A+KIIDK  + GKE  +ENEI +++          C       H NIV+L E YE + +V+LVMELV  G+LFD I +   ++E  A+ ++  +  A+ Y+H + +VHRDLKPENL+     D S  + ++DFGL+ ME   ++ T CGTP YVAPE+L++K Y   VD+W++GVI+YILLCG+PPF   + N   LF  I  G+FEF SPYWD+IS   K  IK L+ V  + R +    L H W+
Sbjct:   10 GKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDS-KIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFY--DENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWI 302
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Match: CaMKI (gene:FBgn0016126 transcript:FBtr0089065)

HSP 1 Score: 226.483 bits (576), Expect = 2.745e-69
Identity = 121/296 (40.88%), Postives = 178/296 (60.14%), Query Frame = 3 
Query:  240 GSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTE-YALKIIDKSRMMGKESMIENEIWIMKL---------C------NHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA-MEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            G     K  ++L+    I +++ +  +LG G F+ V+LA  + +  E +A+KIIDK  + GKE  +ENEI +++          C       H NIV+L E YE + +V+LVMELV  G+LFD I +   ++E  A+ ++  +  A+ Y+H + +VHRDLKPENL+     D S  + ++DFGL+ ME   ++ T CGTP YVAPE+L++K Y   VD+W++GVI+YILLCG+PPF   + N   LF  I  G+FEF SPYWD+IS   K  IK L+ V  + R +    L H W+
Sbjct:   10 GKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDS-KIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFY--DENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWI 302
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Match: dclk2a (doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-050420-170])

HSP 1 Score: 316.235 bits (809), Expect = 1.923e-100
Identity = 157/298 (52.68%), Postives = 208/298 (69.80%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ 1124
            R L++S I+  ++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV D+A AL YLH   IVHRD+KPENL+V  + +G+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G+ EF SP+WD IS   K+LI  +L V+ + R +  DVLSH W+               GK+ +  N  QKQ
Sbjct:  381 RNLAASTIL-DKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQ 677
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Match: dclk2a (doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-050420-170])

HSP 1 Score: 318.161 bits (814), Expect = 2.448e-100
Identity = 166/344 (48.26%), Postives = 226/344 (65.70%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ-------RVLELEDLAKENLESFQRHKKELRTSINREIQAAYQNPK 1241
            R L++S I+  ++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV D+A AL YLH   IVHRD+KPENL+V  + +G+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G+ EF SP+WD IS   K+LI  +L V+ + R +  DVLSH W+               GK+ +  N  QKQ        V+    L KE ++    H+++ R     E + +  NP+
Sbjct:  381 RNLAASTIL-DKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQ--LSHRRQDRNPPRPEKRPSSTNPE 721
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Match: dclk2a (doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-050420-170])

HSP 1 Score: 318.546 bits (815), Expect = 2.461e-100
Identity = 166/344 (48.26%), Postives = 226/344 (65.70%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ-------RVLELEDLAKENLESFQRHKKELRTSINREIQAAYQNPK 1241
            R L++S I+  ++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV D+A AL YLH   IVHRD+KPENL+V  + +G+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G+ EF SP+WD IS   K+LI  +L V+ + R +  DVLSH W+               GK+ +  N  QKQ        V+    L KE ++    H+++ R     E + +  NP+
Sbjct:  390 RNLAASTIL-DKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQ--LSHRRQDRNPPRPEKRPSSTNPE 730
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Match: dclk2a (doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-050420-170])

HSP 1 Score: 318.546 bits (815), Expect = 2.461e-100
Identity = 166/344 (48.26%), Postives = 226/344 (65.70%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ-------RVLELEDLAKENLESFQRHKKELRTSINREIQAAYQNPK 1241
            R L++S I+  ++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV D+A AL YLH   IVHRD+KPENL+V  + +G+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G+ EF SP+WD IS   K+LI  +L V+ + R +  DVLSH W+               GK+ +  N  QKQ        V+    L KE ++    H+++ R     E + +  NP+
Sbjct:  390 RNLAASTIL-DKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQ--LSHRRQDRNPPRPEKRPSSTNPE 730
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Match: dclk2a (doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-GENE-050420-170])

HSP 1 Score: 318.546 bits (815), Expect = 3.053e-100
Identity = 166/344 (48.26%), Postives = 226/344 (65.70%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ-------RVLELEDLAKENLESFQRHKKELRTSINREIQAAYQNPK 1241
            R L++S I+  ++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV D+A AL YLH   IVHRD+KPENL+V  + +G+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G+ EF SP+WD IS   K+LI  +L V+ + R +  DVLSH W+               GK+ +  N  QKQ        V+    L KE ++    H+++ R     E + +  NP+
Sbjct:  409 RNLAASTIL-DKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHFNSVQKQSNTSAGVSVIMNTALDKETIQ--LSHRRQDRNPPRPEKRPSSTNPE 749
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Match: ovch1 (ovochymase 1 [Source:Xenbase;Acc:XB-GENE-6449526])

HSP 1 Score: 345.895 bits (886), Expect = 1.961e-111
Identity = 161/265 (60.75%), Postives = 208/265 (78.49%), Query Frame = 3 
Query:  303 FEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVS 1097
            +E+ + +GDGNFAVVK+        EYA+KIIDKS++ GKE +IENE+ I+K  +H NIVKL  +YET +E++L++E ++ GDLFD IT+++KF+E  AA M+ D+  AL Y+HS+ IVHRDLKPENL+V  + DGS +LKLADFGLA+     I+TVCGTPTYVAPEILSEKGY L+VD+WA GVI YILLCGFPPFRS +RNQEELFQIIQSG +EF+ PYWD IS EVKDLI KLLV++ ++R S   VL H W+ ++G+ +
Sbjct:  429 YEIGRTIGDGNFAVVKVCRPWNENQEYAMKIIDKSKLRGKEDIIENEVRIIKHLSHPNIVKLFSDYETEKEIYLILEYIRGGDLFDVITESIKFTEHDAALMLIDLCEALKYIHSKHIVHRDLKPENLLVQHNPDGSKSLKLADFGLAIYATGPIFTVCGTPTYVAPEILSEKGYGLKVDMWATGVILYILLCGFPPFRSPDRNQEELFQIIQSGEYEFLPPYWDHISEEVKDLISKLLVLNPEIRYSAKCVLQHSWVTSRGQTN 693
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Match: arhgap24 (Rho GTPase activating protein 24 [Source:Xenbase;Acc:XB-GENE-996257])

HSP 1 Score: 312.768 bits (800), Expect = 3.906e-102
Identity = 155/297 (52.19%), Postives = 199/297 (67.00%), Query Frame = 3 
Query:  243 SIVMGKLCRQLSSSDI---------------IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            S+   K+C  +  SDI               I +R++V + +GDGNFA+VK  + R T  EYALKII+KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A  M+ ++ +A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G+ +F SPYWD +S   K+LI  +L VD   R S + VL H W+   G
Sbjct:   48 SLASTKVCSSMDESDIVVEDIMDEGFQVPVSISERYKVGRTIGDGNFAIVKECIERSTGREYALKIINKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPSELYLVMELVKGGDLFDAITSTNKYTERDANGMLYNLMSAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATVVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGHMDFPSPYWDNVSDSAKELITMMLQVDVDQRYSALKVLEHPWVNDDG 344
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Match: arhgap24 (Rho GTPase activating protein 24 [Source:Xenbase;Acc:XB-GENE-996257])

HSP 1 Score: 311.612 bits (797), Expect = 7.967e-102
Identity = 154/279 (55.20%), Postives = 195/279 (69.89%), Query Frame = 3 
Query:  267 RQLSSSD-----IIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            R LSSS       I +R++V + +GDGNFA+VK  + R T  EYALKII+KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A  M+ ++ +A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G+ +F SPYWD +S   K+LI  +L VD   R S + VL H W+   G
Sbjct:   48 RSLSSSARSVPVSISERYKVGRTIGDGNFAIVKECIERSTGREYALKIINKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPSELYLVMELVKGGDLFDAITSTNKYTERDANGMLYNLMSAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATVVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGHMDFPSPYWDNVSDSAKELITMMLQVDVDQRYSALKVLEHPWVNDDG 326
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Match: arhgap24 (Rho GTPase activating protein 24 [Source:Xenbase;Acc:XB-GENE-996257])

HSP 1 Score: 308.531 bits (789), Expect = 2.688e-101
Identity = 149/266 (56.02%), Postives = 190/266 (71.43%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFA+VK  + R T  EYALKII+KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A  M+ ++ +A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G+ +F SPYWD +S   K+LI  +L VD   R S + VL H W+   G
Sbjct:   46 ISERYKVGRTIGDGNFAIVKECIERSTGREYALKIINKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPSELYLVMELVKGGDLFDAITSTNKYTERDANGMLYNLMSAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATVVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGHMDFPSPYWDNVSDSAKELITMMLQVDVDQRYSALKVLEHPWVNDDG 311
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Match: arhgap24 (Rho GTPase activating protein 24 [Source:Xenbase;Acc:XB-GENE-996257])

HSP 1 Score: 308.145 bits (788), Expect = 1.144e-100
Identity = 149/266 (56.02%), Postives = 190/266 (71.43%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFA+VK  + R T  EYALKII+KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A  M+ ++ +A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G+ +F SPYWD +S   K+LI  +L VD   R S + VL H W+   G
Sbjct:   55 ISERYKVGRTIGDGNFAIVKECIERSTGREYALKIINKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPSELYLVMELVKGGDLFDAITSTNKYTERDANGMLYNLMSAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATVVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGHMDFPSPYWDNVSDSAKELITMMLQVDVDQRYSALKVLEHPWVNDDG 320
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Match: Dclk3 (doublecortin-like kinase 3 [Source:MGI Symbol;Acc:MGI:3039580])

HSP 1 Score: 350.132 bits (897), Expect = 1.807e-112
Identity = 177/335 (52.84%), Postives = 230/335 (68.66%), Query Frame = 3 
Query:  120 KIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQ 1124
            K P  L E  A     + ES   +E+   ++   RKP   G I          S+D+  + +++  ++GDGNFA VK   HR+TK  YA+K+IDKS++ GKE ++++EI I++  +H NIVKL E YET  E++L+ME V+ GDLFDAI +NVKF EP AA M+ D+  AL ++H + IVHRD+KPENL+V R++D SITLKLADFGLA  + + I+TVCGTPTYVAPEILSEKGY LEVD+WA GVI YILLCGFPPFRS  R+Q+ELF IIQ G FEF+SPYWD IS   KDL++ LL VD K R +   VL H W+   G  +  +  SQK+
Sbjct:  468 KKPGGLGERRAP----EKESKRKLEEKRPERPSGRKPRPKGII----------SADV-EKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWIEMVGHTN--TGNSQKE 785
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Match: Dclk1 (doublecortin-like kinase 1 [Source:MGI Symbol;Acc:MGI:1330861])

HSP 1 Score: 313.923 bits (803), Expect = 2.747e-103
Identity = 150/266 (56.39%), Postives = 191/266 (71.80%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFAVVK  + R T  EYALKII KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A+ M+ ++A+A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G  +F SPYWD +S   K+LI  +L+V+   R S + VL H W+   G
Sbjct:   79 ITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDG 344
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Match: Dclk1 (doublecortin-like kinase 1 [Source:MGI Symbol;Acc:MGI:1330861])

HSP 1 Score: 314.309 bits (804), Expect = 1.554e-102
Identity = 150/266 (56.39%), Postives = 191/266 (71.80%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFAVVK  + R T  EYALKII KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A+ M+ ++A+A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G  +F SPYWD +S   K+LI  +L+V+   R S + VL H W+   G
Sbjct:   95 ITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDG 360
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Match: Dclk1 (doublecortin-like kinase 1 [Source:MGI Symbol;Acc:MGI:1330861])

HSP 1 Score: 313.153 bits (801), Expect = 2.030e-102
Identity = 150/266 (56.39%), Postives = 191/266 (71.80%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFAVVK  + R T  EYALKII KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A+ M+ ++A+A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G  +F SPYWD +S   K+LI  +L+V+   R S + VL H W+   G
Sbjct:   78 ITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDG 343
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Match: Dclk2 (doublecortin-like kinase 2 [Source:MGI Symbol;Acc:MGI:1918012])

HSP 1 Score: 322.013 bits (824), Expect = 2.084e-102
Identity = 152/276 (55.07%), Postives = 201/276 (72.83%), Query Frame = 3 
Query:  249 VMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            V G  C   S S  + +++ + K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ I++   H NI+ L EE ET  ++FLVMELVK GDLFDAIT + K++E   + MV ++ANAL YLHS  IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I +G  EF +PYWD I+   K+LI ++L V+ + R +  ++LSH W+
Sbjct:  394 VNGNRC---SESFPLLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV 666
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Match: sp|Q9C098|DCLK3_HUMAN (Serine/threonine-protein kinase DCLK3 OS=Homo sapiens OX=9606 GN=DCLK3 PE=2 SV=2)

HSP 1 Score: 357.066 bits (915), Expect = 7.149e-116
Identity = 172/322 (53.42%), Postives = 224/322 (69.57%), Query Frame = 3 
Query:  153 QVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQ 1118
            Q   ++ E  T  E++  ++   RKP   G I              + + +E  +++GDGNFAVVK   HR+T+  YA+KIIDKSR+ GKE M+++EI I++  +H NIVKL E YET  E++L++E V+ GDLFDAI ++VKF EP AA M+ D+  AL ++H + IVHRDLKPENL+V R++D S TLKLADFGLA  + + I+TVCGTPTYVAPEILSEKGY LEVD+WA GVI YILLCGFPPFRS  R+Q+ELF IIQ G+FEF+ PYWD IS   KDL+ +LLVVD K R +   VL H W+   GK + +  + Q
Sbjct:  317 QPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAAN-----------VEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQ 627
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Match: sp|Q8BWQ5|DCLK3_MOUSE (Serine/threonine-protein kinase DCLK3 OS=Mus musculus OX=10090 GN=Dclk3 PE=1 SV=2)

HSP 1 Score: 350.132 bits (897), Expect = 1.264e-111
Identity = 177/335 (52.84%), Postives = 230/335 (68.66%), Query Frame = 3 
Query:  120 KIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQ 1124
            K P  L E  A     + ES   +E+   ++   RKP   G I          S+D+  + +++  ++GDGNFA VK   HR+TK  YA+K+IDKS++ GKE ++++EI I++  +H NIVKL E YET  E++L+ME V+ GDLFDAI +NVKF EP AA M+ D+  AL ++H + IVHRD+KPENL+V R++D SITLKLADFGLA  + + I+TVCGTPTYVAPEILSEKGY LEVD+WA GVI YILLCGFPPFRS  R+Q+ELF IIQ G FEF+SPYWD IS   KDL++ LL VD K R +   VL H W+   G  +  +  SQK+
Sbjct:  468 KKPGGLGERRAP----EKESKRKLEEKRPERPSGRKPRPKGII----------SADV-EKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWIEMVGHTN--TGNSQKE 785
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Match: sp|D2I3C6|DCLK2_AILME (Serine/threonine-protein kinase DCLK2 OS=Ailuropoda melanoleuca OX=9646 GN=DCLK2 PE=3 SV=1)

HSP 1 Score: 325.865 bits (834), Expect = 2.339e-102
Identity = 152/276 (55.07%), Postives = 201/276 (72.83%), Query Frame = 3 
Query:  249 VMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            V G  C   S S  + +++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ I++   H NI+ L EE ET  E+FLVMELVK GDLFDAIT + K++E   + MV ++ANAL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I +G  EF +PYWD I+   K+LI ++L V+ + R +  ++LSH W+
Sbjct:  396 VNGNRC---SESSTLLEKYKIGKVIGDGNFAVVKECMDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV 668
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Match: sp|O08875|DCLK1_RAT (Serine/threonine-protein kinase DCLK1 OS=Rattus norvegicus OX=10116 GN=Dclk1 PE=1 SV=1)

HSP 1 Score: 314.694 bits (805), Expect = 4.383e-102
Identity = 150/266 (56.39%), Postives = 191/266 (71.80%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + +GDGNFAVVK  + R T  EYALKII KS+  GKE MI+NE+ I++   H NIV L EE +   E++LVMELVK GDLFDAIT   K++E  A+ M+ ++A+A+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFR S  +QE LF  I  G  +F SPYWD +S   K+LI  +L+V+   R S + VL H W+   G
Sbjct:   79 ITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDG 344
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Match: sp|Q8N568|DCLK2_HUMAN (Serine/threonine-protein kinase DCLK2 OS=Homo sapiens OX=9606 GN=DCLK2 PE=1 SV=4)

HSP 1 Score: 324.324 bits (830), Expect = 5.400e-102
Identity = 152/276 (55.07%), Postives = 200/276 (72.46%), Query Frame = 3 
Query:  249 VMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            V G  C   S S  + +++++ K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ I++   H NI+ L EE ET  E+FLVMELVK GDLFDAIT + K++E   + MV ++ANAL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I +G  EF +PYWD I+   K+LI ++L V+ + R +   +LSH W+
Sbjct:  379 VNGNRC---SESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWV 651
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Match: A0A2R2MSE3 (serine/threonine-protein kinase DCLK1 OS=Lingula unguis OX=7574 GN=LOC106181152 PE=4 SV=1)

HSP 1 Score: 424.091 bits (1089), Expect = 1.825e-134
Identity = 202/313 (64.54%), Postives = 250/313 (79.87%), Query Frame = 3 
Query:  255 GKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMA-KGKVSQISNESQKQRVL--ELEDLAKENLESFQRHK 1184
            G+L  QL ++D I++++E  + LGDGNFA+VK +   K+  E+A+KIIDKS++ GKE M+ +EI +MKLC+H NIVKL EEYET +E++L+MELVK GDLFDAITQ+VKF EP AAKM  D+A ALFYLHSRRIVHRDLKPENL+V+R+KD SI LKLADFGLAME+K+ IYTVCGTPTYVAPEIL+E GY LEVD+WALGVITYILLCGFPPFRS +RNQ ELF+ I+SG +EF+SPYWD IS+  KD+I+ LLVV RK R + IDVL+H W++   G V +  N    +R L  + ED AK NLESF+  K
Sbjct:  779 GRLGIQLQNADPIFEKYEAGRTLGDGNFAIVKQSKLIKSGQEHAMKIIDKSKLKGKEHMVMSEIEVMKLCSHTNIVKLYEEYETPKEIYLIMELVKGGDLFDAITQSVKFPEPEAAKMATDVAQALFYLHSRRIVHRDLKPENLLVMRNKDNSIMLKLADFGLAMEVKEPIYTVCGTPTYVAPEILTEIGYGLEVDMWALGVITYILLCGFPPFRSPDRNQSELFEYIKSGEYEFLSPYWDGISYAAKDMIEHLLVVSRKSRYTAIDVLTHPWIVTVGGSVPKPDNWDAYRRNLRKQYEDEAKRNLESFREKK 1091
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Match: R7TC90 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_217544 PE=4 SV=1)

HSP 1 Score: 415.616 bits (1067), Expect = 3.201e-134
Identity = 199/312 (63.78%), Postives = 250/312 (80.13%), Query Frame = 3 
Query:  258 KLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAK-GKVSQISNESQKQRVL--ELEDLAKENLESFQRHK 1184
            KL RQ+SS   +  R++V+K LGDGNFA+VK    ++TK +YA+KIIDK+++ GKE MIENEI IMK CN  NIV+L EE+ET+++++L+MELVK GDLFDAITQ+VKF E  ++ MV D+ANAL YLHSR IVHRDLKPENLMV  +KDGS++LKLADFGLAME+K+ I+TVCGTPTYVAPEILSE GY LEVD+WALGVI+YILLCGFPPFRS +RNQ ELF+ I++G +EF+SPYWDKIS   KDLI +LLVVDRK R + ID LSH W++   G +   SN  Q Q  L  EL+D AK NL+++++ +
Sbjct:  488 KLERQVSSVQHVMDRYDVSKTLGDGNFAIVKQCQLKETKADYAMKIIDKAKLKGKEQMIENEIEIMKKCNQANIVRLIEEFETKDDIYLIMELVKGGDLFDAITQSVKFPEVKSSSMVRDLANALHYLHSREIVHRDLKPENLMVCHNKDGSMSLKLADFGLAMEVKQDIFTVCGTPTYVAPEILSETGYGLEVDMWALGVISYILLCGFPPFRSPDRNQTELFEFIKAGEYEFLSPYWDKISRSAKDLISRLLVVDRKKRFTAIDTLSHAWIITNGGSLPAPSNLEQHQLTLRRELKDEAKVNLQNYKQGR 799
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Match: A0A210QQR8 (Serine/threonine-protein kinase DCLK3 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT04931 PE=4 SV=1)

HSP 1 Score: 407.142 bits (1045), Expect = 1.856e-130
Identity = 199/335 (59.40%), Postives = 255/335 (76.12%), Query Frame = 3 
Query:  192 EKSTQDKILLRKPSLPGSIVM-GKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQRVL-----ELEDLAKENLESFQR 1178
            +K   DK + RK      IV   K  RQ+S    I  ++++ K LGDGNFA+VK A  + TK E+A+KIIDK+++ GKE M+ENEI IMK C H NIVKL EEYET ++++LVMELVK GDLFDAITQ+VKF E  +A MV D+ NALFYLHSR IVHRDLKPENL+V R+KD +ITLKLADFGLAM++K  IYTVCGTPTYVAPEILSE GY LEVD+WA+GVI YILLCGFPPFRS++RNQ ELF+ I++G +EF+SPYWD+IS   KDLI+ LL+V++K R + ID LSH W+M  G + +I++ ++ +++      ELE LAK + +S+ +
Sbjct:  513 DKEGGDKEVQRKKKSKSKIVRKTKYERQVSGDSHILSKYDLGKTLGDGNFAIVKQATLKNTKNEFAMKIIDKAKLKGKEHMVENEIEIMKDCQHPNIVKLYEEYETIDKIYLVMELVKGGDLFDAITQSVKFGEVDSAHMVKDLCNALFYLHSRSIVHRDLKPENLLVHRNKDSTITLKLADFGLAMDVKDPIYTVCGTPTYVAPEILSEIGYGLEVDMWAVGVICYILLCGFPPFRSADRNQTELFEFIKAGEYEFLSPYWDQISRGAKDLIEHLLIVEKKKRFTAIDTLSHPWIMYNGDMGKITDNAELEKLKTKTRNELEALAKTSYDSYMK 847
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Match: K1S2X4 (Serine/threonine-protein kinase DCLK3 OS=Crassostrea gigas OX=29159 GN=CGI_10028458 PE=4 SV=1)

HSP 1 Score: 405.216 bits (1040), Expect = 2.024e-130
Identity = 192/312 (61.54%), Postives = 246/312 (78.85%), Query Frame = 3 
Query:  258 KLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQIS-----NESQKQRVLELEDLAKENLESFQR 1178
            KL RQ+S  + I  ++++ + LGDGNFA+V+ +  +    EYA+K+IDK ++ GKE M+ENEI IMK C+H NIVKL EEYET ++++LVMELVK GDLFDAITQ+VKF E  +A+MV D+ NALFYLHSR IVHRDLKPENL+V R+KDGSI+LKLADFGLAME+K+ I+TVCGTPTYVAPEILSE GY LEVD+WA+GVITYILLCGFPPFRS +RNQ ELF+ I++G +EF+SPYWD IS   KDLI+ LLVVD+K R + I+ LSH W++  G +S+       +E +K    ELE  AK++ +S+Q+
Sbjct:  468 KLERQVSGDEHITNKYDLGRTLGDGNFAIVRQSKLKAGSGEYAMKVIDKPKLRGKEHMVENEIEIMKDCHHHNIVKLYEEYETSDKIYLVMELVKGGDLFDAITQSVKFGEVDSARMVKDLCNALFYLHSRSIVHRDLKPENLLVHRNKDGSISLKLADFGLAMEVKEPIFTVCGTPTYVAPEILSEIGYGLEVDMWAVGVITYILLCGFPPFRSPDRNQTELFEFIKAGEYEFLSPYWDNISPYAKDLIEHLLVVDKKKRYTAIETLSHPWILLNGDMSRPPESSKLDEMRKNTRKELELQAKQSYDSYQK 779
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Match: A0A1I8IN06 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 385.185 bits (988), Expect = 7.095e-129
Identity = 172/276 (62.32%), Postives = 220/276 (79.71%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQ 1118
            +++R+++ + LGDGNFAVV+  + R +  EYA K+IDK ++ GKE M+ NE+ IM+LC H NIV+L +EYET+ E++L+MELVK GDLFDAI+Q VKF+E  A+ MVAD+A AL YLHSRRIVHRDLKPENL+V R KD  I+LKL DFGLAME+++ I+TVCGTPTYVAPEILSE GY LEVD+WALGVI YILLCGFPPFRS +R Q ELFQ+I++G FE++SPYWD +S   KDLI +LLVVD+  R + IDVL H W++++G   +   E Q
Sbjct:    1 VFERYDLGRTLGDGNFAVVRACVKRDSGNEYAAKVIDKKKLRGKEHMVLNEVRIMRLCRHPNIVRLVDEYETKAEIYLIMELVKGGDLFDAISQVVKFNEIQASSMVADIAGALHYLHSRRIVHRDLKPENLLVYRSKDNKISLKLGDFGLAMEVEEAIFTVCGTPTYVAPEILSETGYGLEVDMWALGVIAYILLCGFPPFRSRDRRQSELFQMIKTGTFEYLSPYWDHVSAPAKDLINRLLVVDKAARLTAIDVLCHAWVLSRGGSQRQEQEQQ 276
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Match: dclk2a (doublecortin like kinase 2 [Source:NCBI gene;Acc:103023338])

HSP 1 Score: 319.701 bits (818), Expect = 1.816e-101
Identity = 149/270 (55.19%), Postives = 200/270 (74.07%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            + L+SS I+ ++++V K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFD+IT + K++E  A+ MV ++A AL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G  +F SPYW+ IS   K+LI ++L V+ + R +  DVL H W+
Sbjct:  415 KNLTSSSIL-EKYKVGKIIGDGNFAVVKDCVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLMEEVDTPSELYLVMELVKGGDLFDSITSSTKYTERDASAMVYNLAGALKYLHRMSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATLVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNQQEDLFDQILQGRLDFPSPYWENISHSAKELIGRMLQVNVEARYTAEDVLCHPWV 683
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Match: ENSAMXT00000039497.1 (pep primary_assembly:Astyanax_mexicanus-2.0:15:8818577:8831816:1 gene:ENSAMXG00000040052.1 transcript:ENSAMXT00000039497.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 318.546 bits (815), Expect = 2.104e-101
Identity = 149/266 (56.02%), Postives = 194/266 (72.93%), Query Frame = 3 
Query:  282 SDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM 1079
            S II  +++V K++GDGNFAVVK  + R T  EYALKIIDK++  GKE +I NE+ I++   H +I+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV ++  AL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS    QEELF+ I  G  EF +PYWD ++   KDLI K+L V+   R +  +VLSH W++
Sbjct:  377 SSIISDKYKVGKVIGDGNFAVVKECVERATGQEYALKIIDKAKCSGKEHLIANEVAILRRVRHPSIIMLIEEVDTPTELYLVMELVKGGDLFDAITSSTKYTERDASAMVYNLTGALRYLHRMCIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSERNQQEELFEQILLGRLEFPAPYWDNVTPSAKDLIGKMLQVNVSARYTAEEVLSHPWVL 642
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Match: ENSAMXT00000043405.1 (pep primary_assembly:Astyanax_mexicanus-2.0:15:8818577:8831816:1 gene:ENSAMXG00000040052.1 transcript:ENSAMXT00000043405.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 318.161 bits (814), Expect = 2.265e-101
Identity = 149/266 (56.02%), Postives = 194/266 (72.93%), Query Frame = 3 
Query:  282 SDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM 1079
            S II  +++V K++GDGNFAVVK  + R T  EYALKIIDK++  GKE +I NE+ I++   H +I+ L EE +T  E++LVMELVK GDLFDAIT + K++E  A+ MV ++  AL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS    QEELF+ I  G  EF +PYWD ++   KDLI K+L V+   R +  +VLSH W++
Sbjct:  363 SSIISDKYKVGKVIGDGNFAVVKECVERATGQEYALKIIDKAKCSGKEHLIANEVAILRRVRHPSIIMLIEEVDTPTELYLVMELVKGGDLFDAITSSTKYTERDASAMVYNLTGALRYLHRMCIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSERNQQEELFEQILLGRLEFPAPYWDNVTPSAKDLIGKMLQVNVSARYTAEEVLSHPWVL 628
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Match: dclk2a (doublecortin like kinase 2 [Source:NCBI gene;Acc:103023338])

HSP 1 Score: 319.701 bits (818), Expect = 2.659e-101
Identity = 149/270 (55.19%), Postives = 200/270 (74.07%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            + L+SS I+ ++++V K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFD+IT + K++E  A+ MV ++A AL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G  +F SPYW+ IS   K+LI ++L V+ + R +  DVL H W+
Sbjct:  431 KNLTSSSIL-EKYKVGKIIGDGNFAVVKDCVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLMEEVDTPSELYLVMELVKGGDLFDSITSSTKYTERDASAMVYNLAGALKYLHRMSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATLVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNQQEDLFDQILQGRLDFPSPYWENISHSAKELIGRMLQVNVEARYTAEDVLCHPWV 699
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Match: dclk2a (doublecortin like kinase 2 [Source:NCBI gene;Acc:103023338])

HSP 1 Score: 322.013 bits (824), Expect = 3.104e-101
Identity = 163/330 (49.39%), Postives = 220/330 (66.67%), Query Frame = 3 
Query:  267 RQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM------------AKGKVSQISNESQKQ-------RVLELEDLAKENLESFQRHKKELRT 1199
            + L+SS I+ ++++V K++GDGNFAVVK  + R T  E+ALKIIDK++  GKE +IENE+ +++   H NI+ L EE +T  E++LVMELVK GDLFD+IT + K++E  A+ MV ++A AL YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  +YTVCGTPTYVAPEI++E GY L+VD+WA GVITYILLCGFPPFRS N  QE+LF  I  G  +F SPYW+ IS   K+LI ++L V+ + R +  DVL H W+               GK+ +     QKQ        V+    L KEN++   RH +E  T
Sbjct:  431 KNLTSSSIL-EKYKVGKIIGDGNFAVVKDCVERSTGKEFALKIIDKNKCRGKEHLIENEVAVLRRVKHPNIIMLMEEVDTPSELYLVMELVKGGDLFDSITSSTKYTERDASAMVYNLAGALKYLHRMSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATLVEGPLYTVCGTPTYVAPEIIAESGYGLKVDIWAAGVITYILLCGFPPFRSENNQQEDLFDQILQGRLDFPSPYWENISHSAKELIGRMLQVNVEARYTAEDVLCHPWVTEDAAMENNMKMEVTGKLKKHFTSVQKQGNTSAGVSVIMSTALDKENIQ-LSRHAQENST 758
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010548.1 (pep scaffold:Pmarinus_7.0:GL477749:266235:284843:-1 gene:ENSPMAG00000009555.1 transcript:ENSPMAT00000010548.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 318.546 bits (815), Expect = 1.661e-102
Identity = 171/372 (45.97%), Postives = 227/372 (61.02%), Query Frame = 3 
Query:  102 DAEDDLKIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALH--------RKTKTEYALKIIDKSRMMGKESMIENEIWIM-KLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKIS---WEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQRVLELEDLAKENLESFQRH 1181
            + E D +IP         V   + ++   ++    DK   + P+LP  IV         S   I  R+E+ + +GDGNFA VK             + + + A+KIIDK++++G+E M+ +E+ +  +L  H N+V+L E  E+  + +LV+E V+ GDLFDAIT++V+F+E  AA MVAD+  AL YLH+  IVHRD+KPENL+V R+ DG  TLKLAD GLAME+   IYTVCGTPTYVAPEIL+E GY LEVD+WA GVITYILLCGFPPFRS  R+QEELF+IIQ G +EF+SPYWD IS      KDL+ +LLVVD   R +    L H W+   G                  DL +E   + QRH
Sbjct:  305 NGESDKEIPRQYRNNNGNVVPHKGKAKNKLKDGDADKKSKKFPNLPMPIV---------SLQDIESRYEIGRTIGDGNFATVKECRRVSSGDGSAGEAEWDLAMKIIDKAKLVGREEMLRSEVALTTRLGQHPNVVRLVEAMESPSDAYLVLERVRGGDLFDAITESVRFTERHAAAMVADLCRALQYLHANNIVHRDVKPENLLVQRNADGGTTLKLADLGLAMEVTGPIYTVCGTPTYVAPEILAETGYGLEVDMWAAGVITYILLCGFPPFRSLERDQEELFEIIQLGEYEFLSPYWDHISDGHEAAKDLVSRLLVVDTARRYTARQALHHPWVSDGGAGDHT-------------DLHREVTMNIQRH 654
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007114.1 (pep scaffold:Pmarinus_7.0:GL477366:299514:356138:-1 gene:ENSPMAG00000006368.1 transcript:ENSPMAT00000007114.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 215.698 bits (548), Expect = 1.077e-62
Identity = 126/318 (39.62%), Postives = 180/318 (56.60%), Query Frame = 3 
Query:  171 SESVTLIEKSTQDKILLRKPSLPGSIV----------MGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGL-----AMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNR-NQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            S S     + T+    L  PS  GS++          M  +  +      I  ++++ K++GDGNFAVV+  + R     Y L II +     +E MIE+E+ I++   H NI+ L EE +T  E+++VMELVK GDLFDAIT + K++E  A+ M+ ++ +A+ YLH+  I +RD+KPENL+V      S    L D+ L      +    L  +VC   T+V P     + Y L+VD+WA GVI YILLCGFPPFR+S+  +QE LF  I  G  +F SPYWD IS   K+LI ++L VD   R S   VL+H W+
Sbjct:  360 SHSSLASPRGTEPDDSLNGPSPEGSVLYNLHPLQIWAMKTVEGKFHPPSAITAKYKIGKVIGDGNFAVVRECIERMMIASYMLNIIQRHPPRPQEHMIESEVSILRRVKHPNIILLVEEVDTPSELYMVMELVKGGDLFDAITSSTKYTERDASGMLYNLTSAVAYLHALNI-NRDIKPENLLVRAGMHYSHCTDLTDYSLLIFAATLSPGPLHLSVCDL-TFVCPL---PRSYGLKVDIWAAGVIAYILLCGFPPFRASDGDDQEALFDQILVGQLDFPSPYWDNISLTAKELISRMLQVDVDKRFSAEQVLAHPWV 672
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003135.1 (pep scaffold:Pmarinus_7.0:GL491838:799:5626:1 gene:ENSPMAG00000002863.1 transcript:ENSPMAT00000003135.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.971 bits (489), Expect = 5.663e-59
Identity = 102/257 (39.69%), Postives = 154/257 (59.92%), Query Frame = 3 
Query:  330 GNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELV----KNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAM--EIKKLIYTVCGTPTYV---APEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKW 1073
            G F+ V LA  R T    A+K I K+ + GK++ +ENE+ ++    H+NI+ L++ YET   ++L+M+LV    + G+LFD I +   ++E  A+ ++  +  A+ +LH + +VHRDLKPENL+    +D S  + ++DFGL+       ++ T CGTP YV   APE+L++K Y+  VD W++GVI+YILLCG+PPF   +     LF  I    +EF SPYWD IS   KD I+ L+  D   R +    L H W
Sbjct:    2 GAFSEVVLAEERSTGRHVAIKCIAKTALRGKDNTVENEVCVLSRIKHENIIALEDIYETDSHLYLIMQLVLLLIRGGELFDRIVERGFYTERDASALIRQVLRAVSHLHGQGVVHRDLKPENLLYYSAEDDS-KIMISDFGLSKVEAPGSVMSTACGTPGYVACEAPEVLAQKPYTRAVDCWSIGVISYILLCGYPPFY--DEVDSRLFDQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDVAERFTCEQALQHPW 255
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008748.1 (pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 gene:ENSPMAG00000007907.1 transcript:ENSPMAT00000008748.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.971 bits (489), Expect = 1.301e-57
Identity = 98/269 (36.43%), Postives = 160/269 (59.48%), Query Frame = 3 
Query:  303 FEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESM-IENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEI---KKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVS 1097
            +++ + LG G F+VV+  +   T  E+A KII+  ++  ++   +E E  I +L  H NIV+L E        +LV +LV  G+LF+ I     +SE  A+  +  +  ++ + H   IVHRDLKPENL++     G+  +KLADFGLA+E+   ++  +   GTP Y++PE+L +  Y   VD+WA GVI YILL G+PPF   + +Q +L+Q I++G ++F SP WD ++ E K+LI ++L ++   R +  + L H W+  +  V+
Sbjct:   14 YQLYEELGKGAFSVVRRCVKVSTGQEFAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHESIAEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHQHGIVHRDLKPENLLLASKMKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFW--DEDQHKLYQQIKAGAYDFPSPEWDTVTAEAKNLINQMLTINPAKRITAAEALKHPWICQRSTVA 279
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Match: phkg1b (phosphorylase kinase, gamma 1b (muscle) [Source:ZFIN;Acc:ZDB-GENE-050522-52])

HSP 1 Score: 182.956 bits (463), Expect = 2.531e-53
Identity = 101/275 (36.73%), Postives = 167/275 (60.73%), Query Frame = 3 
Query:  300 RFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIEN-------EIWIMK-LCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIK--KLIYTVCGTPTYVAPEIL------SEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            ++E  ++LG G  +VV+  +H++T  ++A+KIID +     E  +E+       E+ I+K +  H +I+ L + YE+    FLV +L+K G+LFD +T+ V  SE     ++  +   + +LH++ IVHRDLKPEN+++    D ++ ++L+DFG +M+++  + +  +CGTP Y++PE+L      S  GY  EVDLWA GVI Y LL G PPF   +R Q  + ++I  G ++F +P W+  S  VKDLI +LLVV+ + R +    L+H + 
Sbjct:   24 KYEPKEVLGSGVSSVVRRCVHKRTGQDFAVKIIDITPDRLSEEELEDIYSSTVKEVDILKAVSGHPHIITLIDAYESSTFFFLVFDLMKRGELFDYLTEKVALSEKDTRSIMRSIFEVVHFLHAKNIVHRDLKPENILL----DDNMNIRLSDFGFSMQLRPGERLRELCGTPGYLSPELLKCSMDESHPGYGKEVDLWACGVIMYTLLAGSPPF--WHRKQMTMLRLIMDGKYDFSTPEWEDRSDTVKDLISRLLVVEPEKRFTAEQALAHPFF 292
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910])

HSP 1 Score: 187.963 bits (476), Expect = 4.901e-55
Identity = 102/283 (36.04%), Postives = 174/283 (61.48%), Query Frame = 3 
Query:  255 GKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIE---NEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIK---KLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNF--EFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLM 1079
            GK+     +S +  +++   K LG G F VV+ A + +T  + A+KI+ K  + G +  +E   +E+ I++  +H NIV  K+ +E++++ +++ +L K G+LFD I +  KF+E  A +++ ++ +A+ Y+HS+ IVHRDLKPENL+ +   D S  L +ADFG+A  +K   +L+Y   G+  YVAPE+L++ G+    D+W++GVITY LLCG+  FR + R Q+ L +   +G +  +F  PYWD +S + K  I K L +D   R +  ++L   W++
Sbjct:   21 GKMAHVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDES-PLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSAFR-AERVQDFLDECT-TGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLEDPWII 300
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Match: CMK2 (Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005376])

HSP 1 Score: 177.563 bits (449), Expect = 4.762e-51
Identity = 95/265 (35.85%), Postives = 156/265 (58.87%), Query Frame = 3 
Query:  315 KMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKE---SMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIK---KLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFE--FISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAK 1085
            + LG G+F VV+ A    T  + A+KI+ K  + G      M+  E+ I++  +H NIV  K+ +E++++ ++V +L   G+LFD I    KF+E  A +++  +  A+ Y+HS+ +VHRDLKPEN++ +   + S  L +ADFG+A ++K    LIY   G+  YVAPE+L++ G+    D+W++GVITY LLCG+ PF +   + E   +   +  +   F  PYWD IS +VK  I K L ++   R +  ++L   W+ +K
Sbjct:   51 RTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENS-PLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIA--ESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSK 312
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Match: DUN1 (Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role [Source:SGD;Acc:S000002259])

HSP 1 Score: 177.948 bits (450), Expect = 1.060e-50
Identity = 104/306 (33.99%), Postives = 169/306 (55.23%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRM--MGKESMIENEIWIMKLCNHDNIVKLKEEY-----ETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLM--VLRHKDGS-------------ITLKLADFGLAMEIKKLIYT--VCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQKQRVLE 1136
             + ++ + K LG G++A+VK A ++KT  + A+KI    +     K      E  I+    H NIV L + +     +++ + +LV+E + +G+LF+ I +     +  +  +   +   L YLH + I+HRD+KPEN++  + R ++ S             I +K+ADFGLA    ++ +T  +CGTP+YVAPE+L++KGY+ +VDLW+ GVI Y+ LCGFPPF S       L + I    + F SPYWDKI   V  LI  LLV++   R +  + L+H W     + S +S E Q+ ++ +
Sbjct:  196 FFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPF-SDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQITD 500
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 164.081 bits (414), Expect = 1.431e-46
Identity = 87/276 (31.52%), Postives = 160/276 (57.97%), Query Frame = 3 
Query:  270 QLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRM--MGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVD-----RKLRSSTIDVLSHKWL 1076
            +++S     Q F++ + LG G+F  V L   R     YA+K++ K  +  + +     +E  ++ +  H  I+++   ++  +++F++M+ ++ G+LF  + ++ +F  PVA    A++  AL YLHS+ I++RDLKPEN+++   K+G I  K+ DFG A  +  + YT+CGTP Y+APE++S K Y+  +D W+ G++ Y +L G+ PF  SN  +   ++ I +    F  P++++   +VKDL+ +L+  D       L++ T DV +H W 
Sbjct:   76 RVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILL--DKNGHI--KITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMK--TYEKILNAELRF-PPFFNE---DVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF 341
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Match: RAD53 (DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074])

HSP 1 Score: 169.474 bits (428), Expect = 2.926e-46
Identity = 100/292 (34.25%), Postives = 159/292 (54.45%), Query Frame = 3 
Query:  291 IYQRFEV-TKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA--MEIKKLIYTVCGTPTYVAPEILSEKG-------------YSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWD-KISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNES 1115
            I++ F +  +++G G FA VK A+ R T   +A+KII K +++G    +  E+ +++  NH  IV+LK  YE  E  ++VME V  GDL D +  +    E    ++   +  A+ Y+HS  I HRDLKP+N+++   +D  + +K+ DFGLA        + T CGT  YVAPE++  K              YS  VD+W++G + Y++L G  PF  S   Q++L++ I  G++    P  D +IS E +D I  LL VD   RS+    L+H W+    K+S + ++S
Sbjct:  193 IFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILI--EQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGS--TQDQLYKQIGRGSYHE-GPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI----KMSPLGSQS 475
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Match: EDO42432 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1C2])

HSP 1 Score: 347.821 bits (891), Expect = 1.651e-115
Identity = 163/284 (57.39%), Postives = 206/284 (72.54%), Query Frame = 3 
Query:  222 RKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKW 1073
            RKP  P      K  R L +   +   +   + LGDGNFA+V+    + T+ E+A+KIIDK ++ GKE MI++EI IM+ C H NIV+L E+Y++  E++LVMEL+K GDLFDAI+ +VKF+E VA     DM  AL YLH R+IVHRDLKPENL+V +  DG   LKLADFGLAME+   I+TVCGTPTYVAPEIL E GY L+VD+WA GVITYI+LCGFPPFRS NR+Q+ELF +IQSG FEF+SPYWD +S + KDLI  +LVVD   R++   VL H+W
Sbjct:  225 RKPQSP------KYKRPLVTDKEVTDVYNFGQKLGDGNFAIVRQCKDKITQKEFAIKIIDKRKIRGKEKMIDDEIAIMRRCRHPNIVRLFEDYDSATEIYLVMELIKGGDLFDAISSSVKFTEHVAKSYFRDMCKALAYLHKRKIVHRDLKPENLLVHKRSDGQTHLKLADFGLAMEVTAPIFTVCGTPTYVAPEILEENGYGLKVDMWAAGVITYIMLCGFPPFRSPNRDQDELFDLIQSGEFEFLSPYWDPVSDDAKDLISTMLVVDPTKRATADQVLQHRW 502
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Match: EDO44488 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVP7])

HSP 1 Score: 323.939 bits (829), Expect = 1.430e-109
Identity = 155/258 (60.08%), Postives = 198/258 (76.74%), Query Frame = 3 
Query:  303 FEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            + + K++GDGNFAVV+   HRKT  EYALKII+K+++ GKE MIENEI I++   H++IV+L EEYET  E+FLVMELVK GDLF+AI +  K++E  A+ MV D+A+AL YLH   IVHRD+KPENL+VL   +G  +LKLADFGLAME+K  ++ VCGTPTYVAPEIL E GY L+VD+WA GVI+YILLCGFPPFRS   +Q+ELF +I +G FE++SP+W+ IS   KDLI  +LVVD   R S   VL+H W+
Sbjct:    1 YRIGKVIGDGNFAVVRECKHRKTNKEYALKIINKAKVKGKEHMIENEISILRRVKHNHIVELIEEYETPREIFLVMELVKGGDLFEAIVEATKYTEVHASHMVRDLASALDYLHCNSIVHRDIKPENLLVLNLPNGRKSLKLADFGLAMEVKSPMFLVCGTPTYVAPEILDESGYGLKVDIWAAGVISYILLCGFPPFRSP--DQDELFDLILAGEFEYLSPFWNDISSSAKDLIDHMLVVDANQRYSAKQVLAHPWV 256
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Match: EDO36253 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ85])

HSP 1 Score: 224.172 bits (570), Expect = 4.905e-70
Identity = 115/268 (42.91%), Postives = 170/268 (63.43%), Query Frame = 3 
Query:  285 DIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLA-MEIK-KLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMA 1082
            D I +++++ ++LG G F+ V LA  + T + +A+K I K  + GKE  +ENEI I+K   H NI+ LK+ ++ +  ++LVM+LV+ G+LFD I +   ++E  A+ +V  +  A  YLHS  IVHRDLKPENL+     + S  + ++DFGL+ +E +   + T CGTP YVAPE+L ++ Y   VD W++GVITYILLCG+PPF   + +   LF  I    +EF SPYWD+IS   KD I+ L+ +D KLR +    LSH W+  
Sbjct:   11 DKITKKYDLREVLGTGAFSEVVLAEEKATGSLFAVKCISKKELKGKEESVENEIAILKKVRHKNIIGLKDIFDNKSHLYLVMDLVQGGELFDRIVEKGNYTEQDASALVQQILEAADYLHSLGIVHRDLKPENLLYYSPDEDS-KIMISDFGLSKIEAQGSFMDTACGTPGYVAPEVLKQQPYGKAVDCWSIGVITYILLCGYPPFY--DDSDANLFAQIMRAEYEFDSPYWDEISESAKDFIRHLMELDPKLRYTCRQALSHPWICG 275
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Match: EDO42276 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1X1])

HSP 1 Score: 209.534 bits (532), Expect = 3.319e-64
Identity = 109/270 (40.37%), Postives = 165/270 (61.11%), Query Frame = 3 
Query:  273 LSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKK--LIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            LS  + I   +++ K LG G  +VVKL   + T  E+A+KI+ K+     + +I+ E  I+   NH NI+ +KE +ET   +F+V+ELV  G+LFD + +   + E  AA  +  +  A+ +LH   IVHRDLKPENL+    ++ S  LK+ADFGL+  + +  +  TVCGTP Y APE+L  + Y   VD+WA+GVI YILLCGF PF   +   +++FQ I   +++F+SP+WD +S   KDL+K+L+  D+  R +    L H W+
Sbjct:    8 LSRKEPIEDFYDIGKELGRGASSVVKLCRQKGTNKEFAVKIMKKTV---DKKIIQTETGILFRINHPNIIHMKELFETHTHLFMVLELVTGGELFDRVVEKGYYCEKDAADAIKMILEAVGHLHKNDIVHRDLKPENLLYANEREDS-PLKIADFGLSKILPQEVMTSTVCGTPGYCAPEVLKGESYDTGVDMWAIGVIAYILLCGFEPF--YDETDQQMFQRILKCDYDFVSPWWDDVSSGAKDLVKRLITGDKNKRLTAKQALDHPWV 271
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Match: EDO49898 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF52])

HSP 1 Score: 204.912 bits (520), Expect = 1.075e-60
Identity = 112/323 (34.67%), Postives = 180/323 (55.73%), Query Frame = 3 
Query:  273 LSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKE-SMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEI---KKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQISNESQK-------------QRVLELEDLAKENLESFQRHKKE 1190
            ++      +++E+ + LG G F+ V+   HR+TK EYA+KI+D   M  ++   +E E  I +   H N+V+L     +    FLV +LV  G+LF+ I     +SE  A+  +  +  ++ + H   IVHRDLKPENL++   + G++ +KLADFGLA+E+   +   Y   GTP Y++PE+L +  Y   VDLWA GVI YILL G+PPF   +  Q++L+  I++G +++ SP WD ++ + KDLI K+L VD   R +  + L H W++ + +++   +  Q              +  +    LA  N  S  RHKK+
Sbjct:    7 ITEGGTFNEKYELKEELGKGAFSTVRKCCHRETKIEYAVKILDTKNMTQRDVHKVEREARICRHLRHPNVVRLHANIMSDGFYFLVFDLVTGGELFEDIVAREYYSEADASHCIQQVLLSVQHCHENGIVHRDLKPENLLLASRERGAM-VKLADFGLAIEVDGERLGWYGFAGTPGYLSPEVLKKDPYGKPVDLWACGVILYILLVGYPPF--WDEEQQKLYSQIKAGTYDYPSPEWDTVTADAKDLIDKMLTVDAPKRITAAEALKHPWIVNRERIASKVHRQQTLDGLKRFNARRKLRGAIHATILATHNFSSGSRHKKK 326
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Match: ENSORLT00000003850.2 (serine/threonine-protein kinase DCLK2 [Source:NCBI gene;Acc:101173659])

HSP 1 Score: 315.464 bits (807), Expect = 8.219e-100
Identity = 150/266 (56.39%), Postives = 194/266 (72.93%), Query Frame = 3 
Query:  279 SSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            SS II ++++V K++GDGNFAVVK  + R T  E+ALKIIDK+R  GKE +IENE+ +++   H +I++L E  ET  ++FLVMELVK GDLFDAIT + K+SE  A+ MV ++A A+ YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  ++TVCGTPTYVAPEI++E GY L+VD+WA GVI YILLCGFPPFRS N  QEELF  I  G  EF SP WD IS   K LI ++L V+   R +  +VLSH W+
Sbjct:  420 SSSIINEKYKVGKVIGDGNFAVVKECVERATGQEFALKIIDKARCSGKEHLIENEVAVLRRVRHPSIIQLIEVDETPSQLFLVMELVKGGDLFDAITSSTKYSERDASAMVYNLAGAVKYLHRMNIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLFTVCGTPTYVAPEIIAETGYGLKVDIWAAGVIAYILLCGFPPFRSENNVQEELFDQILRGKLEFPSPDWDTISLPAKMLISQMLQVNVDARFTAEEVLSHPWV 685
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Match: ENSORLT00000031333.1 (serine/threonine-protein kinase DCLK2 [Source:NCBI gene;Acc:101173659])

HSP 1 Score: 315.464 bits (807), Expect = 8.219e-100
Identity = 150/266 (56.39%), Postives = 194/266 (72.93%), Query Frame = 3 
Query:  279 SSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWL 1076
            SS II ++++V K++GDGNFAVVK  + R T  E+ALKIIDK+R  GKE +IENE+ +++   H +I++L E  ET  ++FLVMELVK GDLFDAIT + K+SE  A+ MV ++A A+ YLH   IVHRD+KPENL+V  + DG+ +LKL DFGLA  ++  ++TVCGTPTYVAPEI++E GY L+VD+WA GVI YILLCGFPPFRS N  QEELF  I  G  EF SP WD IS   K LI ++L V+   R +  +VLSH W+
Sbjct:  420 SSSIINEKYKVGKVIGDGNFAVVKECVERATGQEFALKIIDKARCSGKEHLIENEVAVLRRVRHPSIIQLIEVDETPSQLFLVMELVKGGDLFDAITSSTKYSERDASAMVYNLAGAVKYLHRMNIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLFTVCGTPTYVAPEIIAETGYGLKVDIWAAGVIAYILLCGFPPFRSENNVQEELFDQILRGKLEFPSPDWDTISLPAKMLISQMLQVNVDARFTAEEVLSHPWV 685
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Match: dclk1a (serine/threonine-protein kinase DCLK1 [Source:NCBI gene;Acc:101167140])

HSP 1 Score: 312.768 bits (800), Expect = 6.311e-99
Identity = 148/266 (55.64%), Postives = 190/266 (71.43%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I  R++V +M+GDGNFAVV+  +   T  EYALKII+K +  GKE MI+NE+ I++   H NIV L EE +T  E++LVMELVK GDLFDAIT   +++E  A+ M+ ++ANA+ YLHS  IVHRD+KPENL+V  H DGS +LKL DFGLA  +   +YTVCGTPTYVAPEI+SE GY L+VD+WA GVITYILLCGFPPFR  + +QE LF  I  G  EF  PYWD +S   K+LI+ +L V+   R + + VL H W+  +G
Sbjct:  378 ISDRYKVGRMIGDGNFAVVRECVELSTGREYALKIINKGKCRGKEHMIQNEVAILRRVKHPNIVLLIEEVDTYNELYLVMELVKGGDLFDAITSANRYTERDASGMLHNLANAIKYLHSLNIVHRDIKPENLLVYEHADGSKSLKLGDFGLATVVDGPLYTVCGTPTYVAPEIISETGYGLKVDIWAAGVITYILLCGFPPFRGCSDDQEALFDQILMGQLEFPFPYWDNVSETAKELIRSMLEVEVDQRYTALQVLEHPWVTNEG 643
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Match: dclk1b (serine/threonine-protein kinase DCLK1 [Source:NCBI gene;Acc:101155370])

HSP 1 Score: 308.145 bits (788), Expect = 6.288e-97
Identity = 146/266 (54.89%), Postives = 190/266 (71.43%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + LGDGNFAVV+  + R T  EYALKII K +  GKE MI++E+ I++   H NIV L EE ++  E++LVMELVK GDLF AIT + K++E  A+ M+ ++ANA+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +Y VCGTPTYVAPEI++E GY L+VD+WA G+ITYILLCGFPPFRSS  +QE LF+ I    F+F +PYWD +S   K LI K+L V    R +   VL H W+  +G
Sbjct:  382 IAERYKVGRTLGDGNFAVVRECVERSTGREYALKIISKEKCKGKEHMIQSEVAILRRVKHPNIVLLVEEIDSPSELYLVMELVKGGDLFYAITSSNKYTERDASCMLFNLANAIKYLHSLNIVHRDIKPENLLVFEHQDGSKSLKLGDFGLATIVNGPLYAVCGTPTYVAPEIVAETGYGLKVDVWAAGIITYILLCGFPPFRSSEDDQEALFEQILKCQFDFPTPYWDNVSDAAKTLITKMLEVSVDQRYTAAQVLDHPWVNGEG 647
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Match: dclk1b (serine/threonine-protein kinase DCLK1 [Source:NCBI gene;Acc:101155370])

HSP 1 Score: 307.375 bits (786), Expect = 7.939e-97
Identity = 146/266 (54.89%), Postives = 190/266 (71.43%), Query Frame = 3 
Query:  291 IYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKG 1088
            I +R++V + LGDGNFAVV+  + R T  EYALKII K +  GKE MI++E+ I++   H NIV L EE ++  E++LVMELVK GDLF AIT + K++E  A+ M+ ++ANA+ YLHS  IVHRD+KPENL+V  H+DGS +LKL DFGLA  +   +Y VCGTPTYVAPEI++E GY L+VD+WA G+ITYILLCGFPPFRSS  +QE LF+ I    F+F +PYWD +S   K LI K+L V    R +   VL H W+  +G
Sbjct:  382 IAERYKVGRTLGDGNFAVVRECVERSTGREYALKIISKEKCKGKEHMIQSEVAILRRVKHPNIVLLVEEIDSPSELYLVMELVKGGDLFYAITSSNKYTERDASCMLFNLANAIKYLHSLNIVHRDIKPENLLVFEHQDGSKSLKLGDFGLATIVNGPLYAVCGTPTYVAPEIVAETGYGLKVDVWAAGIITYILLCGFPPFRSSEDDQEALFEQILKCQFDFPTPYWDNVSDAAKTLITKMLEVSVDQRYTAAQVLDHPWVNGEG 647
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Match: SMESG000078466.1 (SMESG000078466.1)

HSP 1 Score: 604.749 bits (1558), Expect = 0.000e+0
Identity = 289/290 (99.66%), Postives = 289/290 (99.66%), Query Frame = 3 
Query:   99 LDAEDDLKIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 968
            LDAEDDLKI TVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP
Sbjct:  678 LDAEDDLKIRTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 967
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Match: SMESG000078466.1 (SMESG000078466.1)

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 289/290 (99.66%), Postives = 289/290 (99.66%), Query Frame = 3 
Query:   99 LDAEDDLKIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 968
            LDAEDDLKI TVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP
Sbjct:  704 LDAEDDLKIRTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 993
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Match: SMESG000078466.1 (SMESG000078466.1)

HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0
Identity = 289/290 (99.66%), Postives = 289/290 (99.66%), Query Frame = 3 
Query:   99 LDAEDDLKIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 968
            LDAEDDLKI TVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP
Sbjct:  695 LDAEDDLKIRTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 984
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Match: SMESG000078466.1 (SMESG000078466.1)

HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0
Identity = 289/290 (99.66%), Postives = 289/290 (99.66%), Query Frame = 3 
Query:   99 LDAEDDLKIPTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 968
            LDAEDDLKI TVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP
Sbjct:  688 LDAEDDLKIRTVLNEVVAQVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISP 977
[Close]
BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Match: SMESG000072629.1 (SMESG000072629.1)

HSP 1 Score: 325.865 bits (834), Expect = 6.110e-102
Identity = 154/282 (54.61%), Postives = 203/282 (71.99%), Query Frame = 3 
Query:  261 LCRQLSSSDIIYQRFEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWIMKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAAKMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAMEIKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRSSNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTIDVLSHKWLMAKGKVSQIS 1106
            L +QL + +   + +++   +G GNF+ VK A  + T   +A KIIDK R+  KE +IE EI I+K C H NIVKL+E++ET  +VFLV E +K GDLFDAI +N+KF E  +A M+ D+  AL Y+HS+ IVHRD+KPENL+    K+G I LKL+DFGLA+EIK+ +Y +CGTPTYVAPEILSE+GY +EVD+WA GVI YILLCGFPPFRS  RNQ ELF+ I++G FE+I PYWD+IS E KDLI  +L+VD   R + +D L H W++  G   + S
Sbjct:  642 LAQQLETDEDFEKYYQLGNSIGSGNFSEVKEAKKKATGKPFAAKIIDKKRLKDKEDLIEEEIRILKSCEHPNIVKLEEQFETPNKVFLVQEYIKEGDLFDAICENIKFPESQSAVMMRDIFRALLYIHSKGIVHRDIKPENLLC-SIKNGLINLKLSDFGLAVEIKEPLYVICGTPTYVAPEILSEQGYGIEVDIWASGVICYILLCGFPPFRSPERNQTELFEFIKAGEFEYIKPYWDEISPESKDLINNMLIVDPLKRFTVLDCLCHPWIITLGNSIRFS 922
The following BLAST results are available for this feature:
BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DCLK31.489e-11653.42doublecortin like kinase 3 [Source:HGNC Symbol;Acc... [more]
DCLK32.220e-11453.42doublecortin like kinase 3 [Source:HGNC Symbol;Acc... [more]
DCLK11.675e-10356.77doublecortin like kinase 1 [Source:HGNC Symbol;Acc... [more]
DCLK22.246e-10355.07doublecortin like kinase 2 [Source:HGNC Symbol;Acc... [more]
DCLK23.253e-10355.07doublecortin like kinase 2 [Source:HGNC Symbol;Acc... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cmk-13.143e-6841.67Calcium/calmodulin-dependent protein kinase type 1... [more]
zyg-81.131e-6637.58Serine/threonine-protein kinase zyg-8 [Source:Uni... [more]
zyg-89.388e-6637.22Serine/threonine-protein kinase zyg-8 [Source:Uni... [more]
F32D8.12.882e-6536.56pep chromosome:WBcel235:V:10880837:10883399:1 gene... [more]
unc-431.017e-5636.33Calcium/calmodulin-dependent protein kinase type I... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG175281.402e-8449.81gene:FBgn0261387 transcript:FBtr0111274[more]
CG175281.402e-8449.81gene:FBgn0261387 transcript:FBtr0111277[more]
CaMKI2.418e-7342.70gene:FBgn0016126 transcript:FBtr0333670[more]
CaMKI2.745e-6940.88gene:FBgn0016126 transcript:FBtr0089067[more]
CaMKI2.745e-6940.88gene:FBgn0016126 transcript:FBtr0089065[more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dclk2a1.923e-10052.68doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-G... [more]
dclk2a2.448e-10048.26doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-G... [more]
dclk2a2.461e-10048.26doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-G... [more]
dclk2a2.461e-10048.26doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-G... [more]
dclk2a3.053e-10048.26doublecortin-like kinase 2a [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ovch11.961e-11160.75ovochymase 1 [Source:Xenbase;Acc:XB-GENE-6449526][more]
arhgap243.906e-10252.19Rho GTPase activating protein 24 [Source:Xenbase;A... [more]
arhgap247.967e-10255.20Rho GTPase activating protein 24 [Source:Xenbase;A... [more]
arhgap242.688e-10156.02Rho GTPase activating protein 24 [Source:Xenbase;A... [more]
arhgap241.144e-10056.02Rho GTPase activating protein 24 [Source:Xenbase;A... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Dclk31.807e-11252.84doublecortin-like kinase 3 [Source:MGI Symbol;Acc:... [more]
Dclk12.747e-10356.39doublecortin-like kinase 1 [Source:MGI Symbol;Acc:... [more]
Dclk11.554e-10256.39doublecortin-like kinase 1 [Source:MGI Symbol;Acc:... [more]
Dclk12.030e-10256.39doublecortin-like kinase 1 [Source:MGI Symbol;Acc:... [more]
Dclk22.084e-10255.07doublecortin-like kinase 2 [Source:MGI Symbol;Acc:... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9C098|DCLK3_HUMAN7.149e-11653.42Serine/threonine-protein kinase DCLK3 OS=Homo sapi... [more]
sp|Q8BWQ5|DCLK3_MOUSE1.264e-11152.84Serine/threonine-protein kinase DCLK3 OS=Mus muscu... [more]
sp|D2I3C6|DCLK2_AILME2.339e-10255.07Serine/threonine-protein kinase DCLK2 OS=Ailuropod... [more]
sp|O08875|DCLK1_RAT4.383e-10256.39Serine/threonine-protein kinase DCLK1 OS=Rattus no... [more]
sp|Q8N568|DCLK2_HUMAN5.400e-10255.07Serine/threonine-protein kinase DCLK2 OS=Homo sapi... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2R2MSE31.825e-13464.54serine/threonine-protein kinase DCLK1 OS=Lingula u... [more]
R7TC903.201e-13463.78Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A210QQR81.856e-13059.40Serine/threonine-protein kinase DCLK3 OS=Mizuhopec... [more]
K1S2X42.024e-13061.54Serine/threonine-protein kinase DCLK3 OS=Crassostr... [more]
A0A1I8IN067.095e-12962.32Protein kinase domain-containing protein OS=Macros... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dclk2a1.816e-10155.19doublecortin like kinase 2 [Source:NCBI gene;Acc:1... [more]
ENSAMXT00000039497.12.104e-10156.02pep primary_assembly:Astyanax_mexicanus-2.0:15:881... [more]
ENSAMXT00000043405.12.265e-10156.02pep primary_assembly:Astyanax_mexicanus-2.0:15:881... [more]
dclk2a2.659e-10155.19doublecortin like kinase 2 [Source:NCBI gene;Acc:1... [more]
dclk2a3.104e-10149.39doublecortin like kinase 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000010548.11.661e-10245.97pep scaffold:Pmarinus_7.0:GL477749:266235:284843:-... [more]
ENSPMAT00000007114.11.077e-6239.62pep scaffold:Pmarinus_7.0:GL477366:299514:356138:-... [more]
ENSPMAT00000003135.15.663e-5939.69pep scaffold:Pmarinus_7.0:GL491838:799:5626:1 gene... [more]
ENSPMAT00000008748.11.301e-5736.43pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 ge... [more]
phkg1b2.531e-5336.73phosphorylase kinase, gamma 1b (muscle) [Source:ZF... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CMK14.901e-5536.04Calmodulin-dependent protein kinase; may play a ro... [more]
CMK24.762e-5135.85Calmodulin-dependent protein kinase; may play a ro... [more]
DUN11.060e-5033.99Cell-cycle checkpoint S/T protein kinase; required... [more]
TPK11.431e-4631.52cAMP-dependent protein kinase catalytic subunit; p... [more]
RAD532.926e-4634.25DNA damage response protein kinase; required for c... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO424321.651e-11557.39Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO444881.430e-10960.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO362534.905e-7042.91Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO422763.319e-6440.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO498981.075e-6034.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000003850.28.219e-10056.39serine/threonine-protein kinase DCLK2 [Source:NCBI... [more]
ENSORLT00000031333.18.219e-10056.39serine/threonine-protein kinase DCLK2 [Source:NCBI... [more]
dclk1a6.311e-9955.64serine/threonine-protein kinase DCLK1 [Source:NCBI... [more]
dclk1b6.288e-9754.89serine/threonine-protein kinase DCLK1 [Source:NCBI... [more]
dclk1b7.939e-9754.89serine/threonine-protein kinase DCLK1 [Source:NCBI... [more]
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BLAST of serine/threonine-protein kinase DCLK1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000078466.10.000e+099.66SMESG000078466.1[more]
SMESG000078466.10.000e+099.66SMESG000078466.1[more]
SMESG000078466.10.000e+099.66SMESG000078466.1[more]
SMESG000078466.10.000e+099.66SMESG000078466.1[more]
SMESG000072629.16.110e-10254.61SMESG000072629.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007209 ID=SMED30007209|Name=serine/threonine-protein kinase DCLK1|organism=Schmidtea mediterranea sexual|type=transcript|length=1381bp
TGAGCCGACATCTACAAATTCGTAACAATAGTTGCAGTGGTGACAGTGAT
AATAGTAAGAATATTAATAATATTAATAATAATAATAAAATTAATAATTT
GGACGCTGAAGACGATCTTAAAATCCCTACAGTCCTTAATGAAGTAGTTG
CTCAAGTTCACAACGTCCAATCAGAATCTGTAACGCTAATTGAAAAATCA
ACTCAGGACAAAATCCTCTTACGGAAACCTTCATTGCCTGGTTCAATAGT
CATGGGTAAATTATGCCGGCAACTTTCGTCTTCCGATATTATCTATCAAA
GATTTGAAGTAACTAAAATGTTAGGAGACGGAAACTTTGCGGTAGTCAAG
TTAGCTTTACACCGTAAAACGAAAACTGAATATGCACTGAAAATTATCGA
CAAATCACGAATGATGGGCAAAGAATCAATGATCGAAAATGAAATATGGA
TTATGAAACTTTGCAACCATGATAATATTGTAAAACTTAAAGAAGAATAT
GAAACTCGTGAAGAAGTATTTTTAGTGATGGAATTAGTCAAGAATGGAGA
TTTATTTGATGCTATTACTCAGAATGTTAAATTCAGTGAGCCAGTTGCAG
CAAAAATGGTGGCAGATATGGCAAATGCTTTATTTTATTTGCACAGTAGA
CGGATAGTGCACAGGGATCTTAAACCAGAAAACCTAATGGTTTTGCGTCA
CAAAGACGGCAGTATCACATTGAAATTAGCGGATTTTGGATTGGCCATGG
AAATAAAAAAATTAATTTACACCGTCTGTGGCACACCGACTTATGTGGCT
CCTGAAATATTATCTGAAAAGGGTTATTCTCTCGAAGTAGATTTATGGGC
TCTTGGAGTTATTACTTACATTTTACTTTGTGGCTTTCCCCCTTTCAGAA
GCTCCAATCGGAATCAAGAAGAATTGTTTCAAATTATACAAAGTGGAAAT
TTTGAATTTATTAGTCCCTATTGGGATAAAATCTCTTGGGAAGTCAAAGA
TTTGATTAAAAAACTTCTAGTAGTTGATCGAAAATTAAGATCCTCAACTA
TTGATGTGCTTTCACATAAATGGCTCATGGCAAAAGGCAAAGTATCACAA
ATATCAAATGAATCACAAAAACAAAGGGTGCTAGAATTAGAAGACCTAGC
TAAAGAAAATTTAGAGAGTTTTCAAAGACATAAAAAGGAGCTTCGAACTT
CCATTAATCGTGAAATCCAAGCTGCTTATCAAAACCCCAAGCAAAAATAA
AGTGCTCCAAATTCCCATTCATTATCAGTCCTTCCATTTCAATTTTTGCA
TCAAATTAATGAAACTGCCTTACTAGATGCTAGAGATCTTATATTTTTAT
TGATGCTTCGACTATGTATCTACAATCCAAG
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protein sequence of SMED30007209-orf-1

>SMED30007209-orf-1 ID=SMED30007209-orf-1|Name=SMED30007209-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=416bp
SRHLQIRNNSCSGDSDNSKNINNINNNNKINNLDAEDDLKIPTVLNEVVA
QVHNVQSESVTLIEKSTQDKILLRKPSLPGSIVMGKLCRQLSSSDIIYQR
FEVTKMLGDGNFAVVKLALHRKTKTEYALKIIDKSRMMGKESMIENEIWI
MKLCNHDNIVKLKEEYETREEVFLVMELVKNGDLFDAITQNVKFSEPVAA
KMVADMANALFYLHSRRIVHRDLKPENLMVLRHKDGSITLKLADFGLAME
IKKLIYTVCGTPTYVAPEILSEKGYSLEVDLWALGVITYILLCGFPPFRS
SNRNQEELFQIIQSGNFEFISPYWDKISWEVKDLIKKLLVVDRKLRSSTI
DVLSHKWLMAKGKVSQISNESQKQRVLELEDLAKENLESFQRHKKELRTS
INREIQAAYQNPKQK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000418head
PLANA:0002056medial muscle cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
GO:0035556intracellular signal transduction
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..21