Guanylate cyclase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30007202 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 770 bits (1987), Expect = 0.000e+0 Identity = 435/1034 (42.07%), Postives = 608/1034 (58.80%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNS--IIVTDHLKVLFRKIFQMYNWSRVKLI---YEQTFLNFCRSV--GTLFDSENYKNKTFKSVVL----LNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNN------QKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAIL--LFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
C + PL V L + P V+ GP C Y+ AP+ R W +P++T GA + +K +EY+ TR + D + L R++ W R L+ Y C + G + N T + L+ T L M + V+ +C P++ R ++L A + +YVF ++D+ ++PW + D +V+ A++A+++ +T + P++ EY F+K++K+ E++ E N FHD LLLY A+ +T+A T +G IT++MWNR+ QG+TG + ID +GDR D+S+ DMD + G F++V NY G Q + V G+ ++W PPP P CG++ ++ + T+ ++ + L L LI F+IY++++ + EL + W + W++VE L S R S RG S G ++ + + F TA YKGN+VA+K+++ K++E+ R +L E+K ++++ NEH+ RF+G C D P +LTEYCP+GSLQDILENE I LDWMF++SL DI +GM++LH+ I HGNLKSSNC+VD RFVLKI D+GLE R L + Y LWTAPE+LR + ++ S DVYSFGII QE+ R+GVF++ ++L PK+I+E VT+ + P+RP L+ E L ++++ W ED RP F+ I+ +R N+ +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H E+ARM+LA L A+ F+I H+P +++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S ++ VL F F + RG V MKGKG TYWL GE
Sbjct: 92 CSDTAAPLA-AVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLT-AGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRL----GWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW-ERGDGQDVS--ARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGS-----------RLTLSGRG---------------SNYGSLLTTEGQ-------------------------FQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD----LDPEQGHTVYAKKLWTAPELLRMASP-PVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEE-LGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944]) HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0 Identity = 297/512 (58.01%), Postives = 375/512 (73.24%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNI-GPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILEN+ INLDWMF++SL+ D+ +GM +LH++I HG+LKSSNC+VDSRFVLKI D+GL R T E +D +A Y LWTAPE+L + KADVYSFGII QE+ R+G FYL ++L PK+IV+ V Q +RP + ++ +E L ++ + W +D + RPDF IKG +R NK G + +ILDNLL RMEQYANNLE+LV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG H EIARM+LA L A+ F+I H+P+ ++ LRIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + D L F + RG V MKGKG TYWL GE
Sbjct: 535 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-NEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039 HSP 2 Score: 159.073 bits (401), Expect = 8.226e-39 Identity = 118/434 (27.19%), Postives = 201/434 (46.31%), Query Frame = 2
Query: 335 TVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIYEQTFLN---FCRSVGTLFDSENYKNKTFKSVVLLNAETLLEID---MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTN------NQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIG-KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFAL--INGFYIYKRVKFQAELNAMNWLIPWDNVE--TREKRHR 1570
V L + P + GP C Y A +AR W +P++T GA K++ Y TL R L + +NW +R L+Y + ++ +F++ N + + V E + + +V +C E + ILL+A + N NG+YVF +D+ +PW N T E +EA++++L +T + P + EY+ F + R E +G N G F+D +LLYA LN+T+ T E+G I KM R G+TG + +D+N DR D+ + M D D+G F+ A+Y G +KQ++ G+ I WV K PP P C ++ + K T++++ + + F + ++ F I++++ + EL +M W I W+ ++ E+ H+
Sbjct: 84 AVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLT-AGAVASGFSAKNDHYRTLVRTGP--SAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW--TGRPIPWV--KGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHK 509
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691]) HSP 1 Score: 459.529 bits (1181), Expect = 3.499e-142 Identity = 312/903 (34.55%), Postives = 471/903 (52.16%), Query Frame = 2
Query: 701 ETLLEIDMGSENAVVVLCVEP-----ESVRRILLKAHKLNFINGEYVFINID-LLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQL-YIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSD-TLPNSELFTKRFQYSKRGLAKFDEESDVLIG-NPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGS-----KKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTF-QRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 3364
+ L I ++++C+ E+ +L AH L +G YVF+ D LL S P+ + N K +EAY ++LT+T + E Y+ F + + ++ + G ++S+ A A+N+ M N + + N G M D NG+ ++Y +LD + +++ + Y ++ + G I + + PP + C + + I ++ + ++ INGF + R + + ++ + +R+ + D T N +KR R F S+V G +P L+ P+ +N N+ A+Y+G+ V LK+ K ++ + + E+ +K+L +E+I +G D+ ++TE+C +GSL+DIL N+ + LDWMFK SLL D+ +GM YLH HG LKS NC+VD RFVLK+ D+G + E L ++E + LLWTAPE+LR L S DVYSF II QEV+ R F + D L ++I+ + K + E+ ++++Q W E RP F I + NKG + NI+D++L +EQY++NLE+L+ +RTE+ EK+KTE LL MLP SVA L + TV E +++V++YFSDIVGFT +SA S P++V++LLN LYT FD+II S DVYKVETIGDAYMV SGLP+RNG H EIA MSL LS++ F++ H P V +RIG+HSGPV AGVVGL MPRYCLFGDTVNTASRMES GLP +IH+S +V +L+ + + + RG+ +KGKG + T+WL G+ + P+P
Sbjct: 231 KALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN----NPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSR-NMQFHGFNQLMRTDSNGNGISEYVILDTNLKE--WELHSTYTVDMEMELLRFGGTPIHFPGGR--PPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRI-------------NKIQLIKGPNRILLTLEDVTFINPHFGSKR---GSRASVSFQITSEVQSGRSPRLSFSSGSLTPAT----------------YENSNI---------AIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEM--MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL---EMLRLSEEESSMEELLWTAPELLRAPRGSRL-GSFAGDVYSFAIIMQEVMVRGTPFCMMD--LPAQEIINRLKKPPPVYRPVVPPEH--APPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKG-FMKPLP 1071
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689]) HSP 1 Score: 418.698 bits (1075), Expect = 4.011e-127 Identity = 237/530 (44.72%), Postives = 331/530 (62.45%), Query Frame = 2
Query: 1823 ALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCL----DAPQH-W-----LLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQR-FIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEF 3379
+Y+G+ V LK+ G + + I K++ L +E++ ++G+ L + P W +++E+C +GSLQD+L +I LDWMFK SLL D+ +G+ YLH HG LKS NC+VD RFVLKI D G +L ++ L E + LWTAPE+LR + + + DV+S II QEVV R+ + + + L P+++V+ V + RP +S ++ E + +++Q W E LRP + + +NKG + NI+D++L +EQY++NLE+L+ +RTE+ EK+KT+ LL MLP SVA L V E +E V++YFSDIVGFT +SA S P++V++LLN LYT FD+II S DVYKVETIGDAYMV SGLPQRNG H EIA MSL LSA+ F++ H P V +RIG+HSGP AGVVGL MPRYCLFGDTVNTASRMES GLP +IH++ +V +LR + + RG+ +KGKG + T+WL G PIP+ +
Sbjct: 553 GVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRA---EDQLWTAPELLRDPA-LERRGTLAGDVFSLAIIMQEVVCRSAPYAM--LELTPEEVVQRVRSPPPL-CRPLVSMDQAPVECIL-LMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRG-FNKPIPKPPDL 1072
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688]) HSP 1 Score: 386.726 bits (992), Expect = 1.315e-115 Identity = 218/506 (43.08%), Postives = 307/506 (60.67%), Query Frame = 2
Query: 1901 IEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQIN------LDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRP--FLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMM-RYLNKGGDSGN--ILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVL-RTFQRFIISKRGQVNMKGKGYQTTYWLHG-EDSVIVDPIPESCE 3376
IE+ K+ ++ ++ +F G + + EYC +GSL+++L N+ I+ +DW FK S+L DI +GM YLHS+ HG LKS+NC+VDSR V+KI DFG + K+ L WTAPE LR+ S K DVYS+GII QE++ R FY ++I + P+RP FL E + +++ W+ED RPDF+ I+ + + D N +D L+ R++ Y+ NLE LV +RT+ Y E+ + + L + +LP+ V L V E YE V+IYFSDIVGFT + STPM+V+++LN +Y +FD I++ DVYKVETIGDAYMV SGLP+RNG+ H +IA+M+L LS + F++ H P + +RIG+HSGP AGVVG+KMPRYCLFGDTVNTASRMES GLPL+IH+S ++ +L RT +F+ RG+ +KG+G +TTYWL G +D P P + E
Sbjct: 531 IELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-------------WTAPEHLRQA-----NISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVE 1017
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 553.903 bits (1426), Expect = 4.014e-177 Identity = 276/525 (52.57%), Postives = 379/525 (72.19%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKK----VEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEN-DEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKV---QLIPYRPFLSE------NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHG 3334
+ + TA++KG VVA+K+L+ K ++++R L+E+KK+K+L ++HI RF G C+D P + ++TEYCPKGSL+DILENE+I LD + K+SLL D+ +G+ +LH S I HG LKSSNC+VDSRFVLK+ DFGL +L +E LE E+AYY+ +LWTAPE+LR + + + K D+YSF II E+++R GVF L + +L P +IV+ V K P RP++SE ++ ++ L ++ W ED RP+ +++ +R LN+ ++ N++DNLL RMEQYANNLE LV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ V+IYFSDIVGFT+LS++STPMQV+ LLN LY FD ++++F VYKVETIGDAYMV SGLP+R D H +IA+MSL+ L + F I H+P+++++LRIG+HSG V AGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S+Q+ D+L F + RG V MKGKG QTTYWL G
Sbjct: 681 QIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPM-GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203 HSP 2 Score: 228.024 bits (580), Expect = 1.064e-60 Identity = 149/422 (35.31%), Postives = 223/422 (52.84%), Query Frame = 2
Query: 392 YSLAPIARLLPFWD--IPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKN-KTFKSVVLLNAETLLEIDMGSE------------------NAVVVLCVEPESVRRILLKAHKLNF-INGEYVFINIDLLTSKTNNQKPWYSKNDTD-EVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKY------GSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIY--KRVKFQAELNAMNWLIPWDNVETREKR 1564
Y+LAP+AR+ FW +P+ T + E+ LTR+ + L L +I + + W ++ R+ G SE Y + K++++ N + + M SE + +++LC P++VR I+L AH L +GEYVFINID+ T ++ ++PW NDT+ E N KAKEAYR+L T++ +R + +EY+NF VK R ++KY G E N F+ F+D++LLYA+ALN+T+ L NG IT +MW RT GITG +SID NGDR +DYS+LD+D F VA Y G V GQ + WV K PP P+CGY++ CP G + M + LL ++ G +I+ +R K + EL AM+W I W+ ++ E +
Sbjct: 112 YALAPVARISKFWGQGVPVFTTTAL--VDELGDRNEFPLLTRMMGSYKS--LGKLVTRIAERFEWQHYFFMFNDEVARGPRNKGR---SECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRLQYRALLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTG-SHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV-GQ-LHWVGGK--PPTDLPICGYDKSKCPQ---GYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 553.903 bits (1426), Expect = 6.881e-177 Identity = 276/525 (52.57%), Postives = 379/525 (72.19%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKK----VEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEN-DEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKV---QLIPYRPFLSE------NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHG 3334
+ + TA++KG VVA+K+L+ K ++++R L+E+KK+K+L ++HI RF G C+D P + ++TEYCPKGSL+DILENE+I LD + K+SLL D+ +G+ +LH S I HG LKSSNC+VDSRFVLK+ DFGL +L +E LE E+AYY+ +LWTAPE+LR + + + K D+YSF II E+++R GVF L + +L P +IV+ V K P RP++SE ++ ++ L ++ W ED RP+ +++ +R LN+ ++ N++DNLL RMEQYANNLE LV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ V+IYFSDIVGFT+LS++STPMQV+ LLN LY FD ++++F VYKVETIGDAYMV SGLP+R D H +IA+MSL+ L + F I H+P+++++LRIG+HSG V AGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S+Q+ D+L F + RG V MKGKG QTTYWL G
Sbjct: 702 QIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPM-GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224 HSP 2 Score: 240.736 bits (613), Expect = 9.334e-65 Identity = 160/441 (36.28%), Postives = 234/441 (53.06%), Query Frame = 2
Query: 335 TVKLLMKSKPGVWFGPICDYSLAPIARLLPFWD--IPIITPCGASGIFRQMKHEEYSTLTRVNSI--IVTDHLKVLF------RKIFQMYNWSRVKLIYEQTFLNFC------RSVGTLFDS-----ENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNF-INGEYVFINIDLLTSKTNNQKPWYSKNDTD-EVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKY------GSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIY--KRVKFQAELNAMNWLIPWDNVETREKR 1564
V+ L++ + G Y+LAP+AR+ P+W IPIITP G + + EY +TR+NS +V+ + LF R IF ++ + + FL R V + + E++ K+ L N V++LC P++VR I+L AH L +GEYVFINID+ T ++ ++PW NDT+ E N KAKEAYR+L T++ +R + +EY+NF VK R ++KY G E N F+ F+D++LLYA+ALN+T+ L NG IT +MW RT GITG +SID NGDR +DYS+LD+D F VA Y G V GQ + WV K PP P+CGY++ CP G + M + LL ++ G +I+ +R K + EL AM+W I W+ ++ E +
Sbjct: 110 AVEQLLRKQIDCIIGYAYGYALAPVARMSPYWKNGIPIITPIGLTMSLDDKR--EYQLMTRINSPYKVVSSAVSTLFNTYKWKRHIFMFHHAKAPSVAVGECFLLMASLQHPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMAN-VIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTG-SHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV-GQ-LHWVGGK--PPTDLPICGYDKSKCPQ---GYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 554.673 bits (1428), Expect = 9.318e-177 Identity = 276/525 (52.57%), Postives = 379/525 (72.19%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKK----VEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEN-DEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKV---QLIPYRPFLSE------NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHG 3334
+ + TA++KG VVA+K+L+ K ++++R L+E+KK+K+L ++HI RF G C+D P + ++TEYCPKGSL+DILENE+I LD + K+SLL D+ +G+ +LH S I HG LKSSNC+VDSRFVLK+ DFGL +L +E LE E+AYY+ +LWTAPE+LR + + + K D+YSF II E+++R GVF L + +L P +IV+ V K P RP++SE ++ ++ L ++ W ED RP+ +++ +R LN+ ++ N++DNLL RMEQYANNLE LV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ V+IYFSDIVGFT+LS++STPMQV+ LLN LY FD ++++F VYKVETIGDAYMV SGLP+R D H +IA+MSL+ L + F I H+P+++++LRIG+HSG V AGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S+Q+ D+L F + RG V MKGKG QTTYWL G
Sbjct: 740 QIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPM-GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262 HSP 2 Score: 222.631 bits (566), Expect = 6.537e-59 Identity = 136/342 (39.77%), Postives = 194/342 (56.73%), Query Frame = 2
Query: 707 LLEIDMGSENAVVVLCVEPESVRRILLKAHKLNF-INGEYVFINIDLLTSKTNNQKPWYSKNDTD-EVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKY------GSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIY--KRVKFQAELNAMNWLIPWDNVETREKR-------HRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLI 1681
L EI + S V++LC P++VR I+L AH L +GEYVFINID+ T ++ ++PW NDT+ E N KAKEAYR+L T++ +R + +EY+NF VK R ++KY G E N F+ F+D++LLYA+ALN+T+ L NG IT +MW RT GITG +SID NGDR +DYS+LD+D F VA Y G V GQ + WV K PP P+CGY++ CP + + M + LL ++ G +I+ +R K + EL AM+W I W+ ++ E + + +D LP S+ + S KFDE+S + I
Sbjct: 280 LREISLQSN--VIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTG-SHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV-GQ-LHWVGGK--PPTDLPICGYDKSKCPGYPLHV----YLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLRSTSRSSVNSDKFDEDSLIPI 610
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 504.212 bits (1297), Expect = 2.711e-165 Identity = 257/524 (49.05%), Postives = 366/524 (69.85%), Query Frame = 2
Query: 1811 FITTALYKGNVVALKQLHGSKK----VEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEN-DEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKV---QLIPYRPFLSE------NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQR-----FIISKRGQVNMKGKGYQTTY 3322
+ TA++KG VVA+K+L+ K ++++R L+E+KK+K+L ++HI RF G C+D P + ++TEYCPKGSL+DILENE+I LD + K+SLL D+ +G+ +LH S I HG LKSSNC+VDSRFVLK+ DFGL +L +E LE E+AYY+ +LWTAPE+LR + + + K D+YSF II E+++R GVF L + +L P +IV+ V K P RP++SE ++ ++ L ++ W ED RP+ +++ +R LN+ ++ N++DNLL RMEQYANNLE LV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ V+IYFSDIVGFT+LS++STPMQV+ LLN LY FD ++++F VYKVETIGDAYMV SGLP+R D H +IA+MSL+ L + F I H+P+++++LRIG+HSG V AGVVG KMPRYCLFGDTVNT+SRMESNGL + + S + + F+ F+ +++ + +GK T +
Sbjct: 115 YTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPM-GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGKKMVTEF 636
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-7 (Receptor-type guanylate cyclase gcy-7 [Source:UniProtKB/Swiss-Prot;Acc:H2L002]) HSP 1 Score: 465.307 bits (1196), Expect = 9.759e-145 Identity = 328/1070 (30.65%), Postives = 524/1070 (48.97%), Query Frame = 2
Query: 302 DCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDH-LKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEID----------MGSENAVVVLCVEPES--VRRILLKAHKLNFINGEYVFINIDLLTSK------TNNQKP-WYSKNDTDEVNFKAKEAYRS---LLTVTAQRPESEEYRNFIKEVKNRTNEK-YGSVEE--------SNKFLGVFHDSLLLYALALNDTMAMN--LTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPV--EGQIIDWVNKKN-LPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALIN---GFYIYKRVKFQAELNAMN--WLIPW---DNVETREK---RHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFD--EESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEI--CSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIV 3352
DC+ S TV L+ K V GP + + +++ PII A G+ + +++ + L V R + + Y WS + +Y T+ + F ++L + + +I + S ++V C++ R+ LL A + I EYV++ D+ + ++P W +DE + +A +A++ + + Q + Y F +E+ R E Y ++ + + G HD++ Y +AL+ + Y N T R + ++ G++G ++I+E G RN +L +D++ ++ Y+ + + W ++KN P P+CG+ CP + I +I +L A+ G Y + + Q E+ +N W IP+ + +++K H + S T S T F+ R F ESD P +A K R + S L DNL+ RFIG+CLD PQ + +C +GS+ D++ I +D F +SL++D+ G+++LH S +G HG L S CL+D R+ +KI ++GL+ LR + Y ++LLW+APE+LR ++ S + DVYS GIIC E++ R GVF + D +P++I+ + K L RP L + + L ++R + E S RP T++ +R +N + N++D++ + +E YA++LEE V++RT++ +EEK+K++ LLY MLPK+VA +L +TV E++E V+I+FSD+V FT L+++ TP+QV+ LLN LYT FD IIE DVYKVETIGD Y+ SGLP RNG+ H+R+IA MSLAFLS++ F++PH P++R+ LRIG++ G V AGVVGL MPR+CLFGD VNTASRMESNG P KIH+S ++ +L F RG+V +KGKG T+WL G+ + V
Sbjct: 87 DCVESEAA-GMTVDLIEKHNVDVIIGPTMNQPTLAAFIVSNYFNRPII----AWGLVNAAQLDDFERFPNAGILSAGQRSLGVAIRAVLKRYEWS--QFVYAYFTEEDTEKCVTMRNDLQQVVSYFGDIILAYSIQVADISNDGMIEALKKIQSRGRIIVTCMKDGIGLRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSDENDTRALKAFKQSIFICDMMGQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENFTVAATYAGQLHDAVYAYGVALDKMLKAGQIAQYRNATAFMR-YFPQSFIGMSGNVTINEKGTRNPTLFLLALDENNNNTRMATIYVENMSATFNALYSDEGVMWASRKNNARPVDVPLCGFTGNLCPKSFVDEYLIWVIVAIVVLFLAITAAACGIYFSIQARRQ-EIERLNRLWQIPFIHLHQINSKQKGKGEHSVRSLQSGTSTLSSRTTVSFKTESRNFLFFSLQRESDY---EPVVA----KKHAYRPRLDDDKCTFMRSLRNLDQDNLN-------------------------------------------------RFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPEMY--------EKKDLLWSAPELLRAE---DIKGSKEGDVYSLGIICAELITRKGVFNMEDRKEDPEEIIYLLKKGGLKSPRPDLEYDHTIEINPALLHLVRDCFTERPSERPSIETVRSQLRGMNSSRND-NLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQGTGAV 1079
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151) HSP 1 Score: 795.423 bits (2053), Expect = 0.000e+0 Identity = 451/1023 (44.09%), Postives = 626/1023 (61.19%), Query Frame = 2
Query: 374 FGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQ----------TFLNFCRSVGTLFDSENYKNKTFKSVVLLNAE-TLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFIN-GEYVFINIDLLTS-KTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNK----FLGVFHDSLLLYALALNDTMAMNLTYE----NGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHS-NIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEND-----EYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLE--PKQIVEFVT-----KVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
FG C+Y LAPI+R W +P++T G + F + K E YSTLTR+ V ++L + R I +NW+R LIY+ FL T+ + Y+ F + A+ T + ++ ++ +V++C +P+S+R+I+L A +LN I+ GEYVFINI+L + + +PWY KNDTD N +A++AY ++LTVT ++P EY E+K EKY N+ F+ F D +LLYA ALN+++ + T NGT + R+MWNR+ GITG ++ID NGDR + YS+LDM+ TG F+IVA+++ + + + I W + PP P+CGY+ CP+ + I I + +++ + F+ Y+ +AE+N+M+W + ++V R+ ++RGL S S V + E + D + FI +++ + VA+K + + + + R+L++E+K++K+L ++H+ +F G CLD + +LLTEYCPKGSLQDILENEQ LDWMF+ SL+ DI RGM +LHS +I HGNLKSSNC+VDSRFVLKI DFGL LR T+ + LE+D +AY+ LLWTAPE+LR + + K DVY+FGII E+ R G FYL E P++I+E V ++Q P+RP L N + IIR+ W ED + RPDF T+K M+R NK ++GNI+DNLL RME YANNLEELV +RT+ Y EEK+K E LLY +LP+SVA QLI + V AE+++ V+IYFSDIVGFTA+SAESTPMQV++ LN LYT FDSI+E+FDVYKVETIGDAYMV SGLP RNG+ H REIAR++LA L A+ F+I H+P R++LRIG+H+G AGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+SE + + L F F+ ++RG V MKGKG TYWL GE
Sbjct: 164 FGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNK-KSESYSTLTRLKGAQV-NNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQ-LGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEF--EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDA------------------------AERGLRG--------------------SFHSLVKQSSQLTLMSEDMVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTR-FDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQK-PFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187) HSP 1 Score: 795.423 bits (2053), Expect = 0.000e+0 Identity = 451/1023 (44.09%), Postives = 626/1023 (61.19%), Query Frame = 2
Query: 374 FGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQ----------TFLNFCRSVGTLFDSENYKNKTFKSVVLLNAE-TLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFIN-GEYVFINIDLLTS-KTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNK----FLGVFHDSLLLYALALNDTMAMNLTYE----NGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHS-NIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEND-----EYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLE--PKQIVEFVT-----KVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
FG C+Y LAPI+R W +P++T G + F + K E YSTLTR+ V ++L + R I +NW+R LIY+ FL T+ + Y+ F + A+ T + ++ ++ +V++C +P+S+R+I+L A +LN I+ GEYVFINI+L + + +PWY KNDTD N +A++AY ++LTVT ++P EY E+K EKY N+ F+ F D +LLYA ALN+++ + T NGT + R+MWNR+ GITG ++ID NGDR + YS+LDM+ TG F+IVA+++ + + + I W + PP P+CGY+ CP+ + I I + +++ + F+ Y+ +AE+N+M+W + ++V R+ ++RGL S S V + E + D + FI +++ + VA+K + + + + R+L++E+K++K+L ++H+ +F G CLD + +LLTEYCPKGSLQDILENEQ LDWMF+ SL+ DI RGM +LHS +I HGNLKSSNC+VDSRFVLKI DFGL LR T+ + LE+D +AY+ LLWTAPE+LR + + K DVY+FGII E+ R G FYL E P++I+E V ++Q P+RP L N + IIR+ W ED + RPDF T+K M+R NK ++GNI+DNLL RME YANNLEELV +RT+ Y EEK+K E LLY +LP+SVA QLI + V AE+++ V+IYFSDIVGFTA+SAESTPMQV++ LN LYT FDSI+E+FDVYKVETIGDAYMV SGLP RNG+ H REIAR++LA L A+ F+I H+P R++LRIG+H+G AGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+SE + + L F F+ ++RG V MKGKG TYWL GE
Sbjct: 164 FGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNK-KSESYSTLTRLKGAQV-NNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQ-LGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEF--EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDA------------------------AERGLRG--------------------SFHSLVKQSSQLTLMSEDMVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTR-FDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQK-PFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG3216 (gene:FBgn0034568 transcript:FBtr0273396) HSP 1 Score: 687.952 bits (1774), Expect = 0.000e+0 Identity = 416/1054 (39.47%), Postives = 596/1054 (56.55%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCG------------ASGIFRQM---KHE---------EYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNA------ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRT----NEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGY--NRKNCPNRKIGAGTISLITMAAILLFALINGFY-----IYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQH--WLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKST-KADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLH 3331
C +R P + + + GP C ++L P+ARL +W+ PIIT G SGI ++ K+E +Y TLTR++ L ++F + + +NW+ V L+ +++ L F +VG + + V LN E L+ D VV+L V VR+ +L AH L NGE+VF+++++ S+ K W K DE + KA++AY +LL V+ +P S ++++F V+ N +G EE N F+G F+D + L +ALN+T+ +G ITR+MWNRT +GITG + ID+NGDR+ADYS+LD+D G F +VA+Y G ++Y V G+ I W + PPP P CG+ N +C G S I + L + + + K++K ELN M+W + D+V + +F SK GL + D E N SL + S + + SFT L + + T +KG VA+K+++ KKV++ LL E+K+ +++++E+ RF+G C+D P+ +LTEYC +GSL+D+LENE I LDW F+ SL+ DI +GM YLH S++ HG L+S NCL+D RFVLKI DFGL L +++ + + YY LLW APE+L TT +T + DVYSFGII +E+V R G + + ++ I+ V Q +RP + E E C L ++ + W ++ RP F TI+ +R + KG N++D+LL+RMEQYANNLE LV ++T Q EK++TE+LLY +LP+ VA QL+ + V E + V+IYFSDIVGFT L A S+PM V+ LN LY+TFD II +DVYKVETIGDAY+V SGLP+ NGD H REIA M+L L A+ F + HKP ++++RIG+HSG VCAGVVG KMP YCLFGDTVNTASRMES G P KIH+S + +L F F + +RG V +KGKG TTYWL+
Sbjct: 141 CSGARAP-GLAADMYFQDDVIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQC--RLILVFASVIRQFNWNHVALLVDRSEL-FSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLK-DASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMK---DEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDC------VGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDV---------------LIEMGGMFG-----SKGGLQRLDVE------NISLQQFGIHSGRASIA----------SFTSLPP------QVYTTIGQFKGERVAIKKVN-VKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQN---YYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVR--QCNGFRPLIRERE-CPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGF-CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLN 1130
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302487) HSP 1 Score: 544.658 bits (1402), Expect = 3.151e-173 Identity = 360/973 (37.00%), Postives = 514/973 (52.83%), Query Frame = 2
Query: 572 YNWSRVKLIY-----------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNA-ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEK-----------YGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITG-EMSIDENGDRNADYSVLDMD-------------KDTGIF-------KIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETRE-KRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYR--NLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQ--LIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGED 3340
+NW++V +Y +T L+ G N + + N E L+E + ++L E V ++ + G+Y + ID+ + + ++V A +A++S L + S + F EV N+ E+ +G V++ + +D++ LYA AL + + NG+ I + + G + IDENGD +Y+VL + G F ++ + +L+ P IDWV P + P CG+ + C N G IS LL + +Y+ +++ EL+++ W I + V+ E +R + + K + L N +R + + LI R S+V S + + + F LYKG + A+K++ K V+I R + E+K +++ +++IC FIG C D P +++EYC +GSL+DILENE + LD MF S++ DI RG+IYLH S I HG L +SNCLVDSR+V+K+ DFGL + E + ++ + LL+ APE+LR+ + + + D YSFGI+ E+ R G F + L P Q ++ V + Q L PYRP L E + + +R+ W E RPDF+TI+ +R L KG NI DN+++ ME+YANNLE LV+ RT+Q EEK+KT+ LL+ MLP+ VA QL + V E YE VSIYFSDIVGFTA+SAE TP+QV++ LN LYT FDSII +DVYKVETIGDAYMV SGLP RNGD+H EIA MSL LSA+ EF+I H+P R+ LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES+G+PLKIH S Q +L + ++RG ++MKGKG Q TYWL GED
Sbjct: 178 FNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEV-NKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSP-----IDWVGGTR--PAAAPRCGFGGEKCVNY---TGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNH--LPRRLP---------PQSTHPLI------------RTSQV-----------SLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF--GETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED 1099
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792) HSP 1 Score: 543.117 bits (1398), Expect = 1.006e-172 Identity = 359/972 (36.93%), Postives = 509/972 (52.37%), Query Frame = 2
Query: 572 YNWSRVKLIY-----------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNA-ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEK-----------YGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITG-EMSIDENGDRNADYSVLDMD-------------KDTGIF-------KIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYR--NLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQ--LIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGED 3340
+NW++V +Y +T L+ G N + + N E L+E + ++L E V ++ + G+Y + ID+ + + ++V A +A++S L + S + F EV N+ E+ +G V++ + +D++ LYA AL + + NG+ I + + G + IDENGD +Y+VL + G F ++ + +L+ P IDWV P + P CG+ + C N G IS LL + +Y+ +++ EL+++ W I + V+ E +R Q S+ K + LI R S+V S + + + F LYKG + A+K++ K V+I R + E+K +++ +++IC FIG C D P +++EYC +GSL+DILENE + LD MF S++ DI RG+IYLH S I HG L +SNCLVDSR+V+K+ DFGL + E + ++ + LL+ APE+LR+ + + + D YSFGI+ E+ R G F + L P Q ++ V + Q L PYRP L E + + +R+ W E RPDF+TI+ +R L KG NI DN+++ ME+YANNLE LV+ RT+Q EEK+KT+ LL+ MLP+ VA QL + V E YE VSIYFSDIVGFTA+SAE TP+QV++ LN LYT FDSII +DVYKVETIGDAYMV SGLP RNGD+H EIA MSL LSA+ EF+I H+P R+ LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES+G+PLKIH S Q +L + ++RG ++MKGKG Q TYWL GED
Sbjct: 178 FNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEV-NKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSP-----IDWVGGTR--PAAAPRCGFGGEKCVNY---TGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHEN-------------------EREQQSQ----KQTRSTHPLI------------RTSQV-----------SLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF--GETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED 1086
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 728.013 bits (1878), Expect = 0.000e+0 Identity = 438/1032 (42.44%), Postives = 598/1032 (57.95%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCR----SVGTLFDSENYKNKTFKSVVLLNAETLLEID-----MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLL--TSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRG-LAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
C S PL V L P + GP CDYS +P+AR W++P+IT GA R + YS++T + L ++ + + W + ++ N R +V + N T +V E L D + + VV +C + E+ R+++++ + F EY F IDL + +++ +PW ++ D D+ AKEA++S+ +T + P++ EY++F+ ++K + + +VE+S N G FHD ++LY+ ALNDTM + + G + ++MWNRT G+TG + +DENGDR D+++ DM D TG ++IV+ Y G ++ I G + W+ K PPP P CG+ N C + + + I + I + + +IY+++K + EL A W + W++++ L S T + S G L D GN + TG N+ IK V K++ ++KV L E+K ++++ NEH+ RFIG C+D P +LTEYCP+GSLQD++E+E I LDWMF++SL+ DI +GM +LH S I HGNLKSSNC+VDSRFVLKI D+GLE +D +A+Y LWTAPE+LR + K DVYSFGII QE+ GVFYL L PK+I+E V + + RP L + SE + +++ + W ED + RPDF IK ++R N G NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R E V AE+++ V+IYFSDIVGFTALSAESTPM+V+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+SE + VL+ F F + RG V MKGKG TYWL GE S
Sbjct: 104 CSDSVAPLV-AVDLKFSYNPWAFIGPGCDYSSSPVARFTTHWEVPMIT-SGA----RALGFNLYSSITNIGP--THKKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW-ARGDADDN--AAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWL--KGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRRACSK-------LTISLRGSNYGSLLTMD-------GNFQIYAK----------------------TGYYKGNITAIK-----------YVNKKRIELTRKV------LFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNL---DDVHAFYARQLWTAPELLRADNPPAC-GTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEGRWPYLRPLLCP-QSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEIS 1063
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 728.013 bits (1878), Expect = 0.000e+0 Identity = 438/1032 (42.44%), Postives = 598/1032 (57.95%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCR----SVGTLFDSENYKNKTFKSVVLLNAETLLEID-----MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLL--TSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRG-LAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
C S PL V L P + GP CDYS +P+AR W++P+IT GA R + YS++T + L ++ + + W + ++ N R +V + N T +V E L D + + VV +C + E+ R+++++ + F EY F IDL + +++ +PW ++ D D+ AKEA++S+ +T + P++ EY++F+ ++K + + +VE+S N G FHD ++LY+ ALNDTM + + G + ++MWNRT G+TG + +DENGDR D+++ DM D TG ++IV+ Y G ++ I G + W+ K PPP P CG+ N C + + + I + I + + +IY+++K + EL A W + W++++ L S T + S G L D GN + TG N+ IK V K++ ++KV L E+K ++++ NEH+ RFIG C+D P +LTEYCP+GSLQD++E+E I LDWMF++SL+ DI +GM +LH S I HGNLKSSNC+VDSRFVLKI D+GLE +D +A+Y LWTAPE+LR + K DVYSFGII QE+ GVFYL L PK+I+E V + + RP L + SE + +++ + W ED + RPDF IK ++R N G NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R E V AE+++ V+IYFSDIVGFTALSAESTPM+V+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+SE + VL+ F F + RG V MKGKG TYWL GE S
Sbjct: 104 CSDSVAPLV-AVDLKFSYNPWAFIGPGCDYSSSPVARFTTHWEVPMIT-SGA----RALGFNLYSSITNIGP--THKKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW-ARGDADDN--AAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWL--KGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEKVLRRACSK-------LTISLRGSNYGSLLTMD-------GNFQIYAK----------------------TGYYKGNITAIK-----------YVNKKRIELTRKV------LFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNL---DDVHAFYARQLWTAPELLRADNPPAC-GTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEGRWPYLRPLLCP-QSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEIS 1063
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2]) HSP 1 Score: 689.108 bits (1777), Expect = 0.000e+0 Identity = 420/1017 (41.30%), Postives = 574/1017 (56.44%), Query Frame = 2
Query: 359 KPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWS-RVKLIY------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGS---ENAVVVLCVEPESVRRILLKAHKLNFINGE-YVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNKF---LGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIG--KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGA-GTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKST-KADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
KP + GP C YS+A + R W +P+IT G + F K EE+ T+ R T L + +NWS R +I+ ++ + T+ EN T + + +T DM + +N +V P ++K + + E Y +D+ + P + + N K ++S+ VT Q P+S EY F KE+ R + + E + G FHD +LYA AL++ +A ++ +G IT +M NR + G+TG +SID+ R D+S+ M + +G + IV +Y G K+ L+ P E I W K PP +P CG++ C + G +++ + A+++F I+ F IY+++K + EL M W I W+ + E+ K H+ R S+RG S G ++ + + F T +KGN+VA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILENE INLDWMF++SL+ DI +GM YLH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E D +A Y LWTAPE+L + H + T K DVYSFGII QE+ RNG FY+ ++L PK+I++ V Q +RP + C E L ++ W ED + RPDF IK + NK L LSRMEQYANNLE LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIA MSLA L + F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMES G L+IHMS + +VL F F + RG V MKGKG TYWL GE +
Sbjct: 108 KPDAFIGPGCTYSVASVGRFASHWKLPLITAGGPAYGFD--KWEEFKTIVRTGP--TTKKLGDFVNYLHGQFNWSSRALMIFHDLKQDDRPHYFLSEGIYTVLREENI---TVLAFPYEDEQTYNYKDMITFIKDNGRIVYICGPLPTFFQIMKLFEDEVKSPEDYAIFYLDVFAESLSGDVPMPWQGSDIQWNDPIK-LFQSVFVVTYQEPDSPEYTAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEK--IQW--PKGCPPLDYPPCGFS--PCKEDHLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRIRWEELQFESPNKYHKRA-------------GSRLTLSQRG---------------SSYGSLITAHGK-------------------------YQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NEDSHALYAKKLWTAPELL--IYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMDLSPKEIIQKVRNGQKPYFRPTTDNSRHCEE-LTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYSQYL---LSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGEKT 1046
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 674.855 bits (1740), Expect = 0.000e+0 Identity = 410/1041 (39.39%), Postives = 579/1041 (55.62%), Query Frame = 2
Query: 284 YADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSEN-------YKN--KTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKND---TDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG----SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPN--RK--IGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRG-TKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGED 3340
Y D +C R P L + K + GP C A A+L FW+I +I+P A F + + Y TLTRV L F +I + + W + +IY+ G + +E+ Y++ + N +L +M ++V+ + VR +L++AHK NG++VF + QK + D D + AK+AY++L ++ +P + Y+ F + V +R+ +G E+ + + HD++ LYA ALN+T+A N +G +TR+MWNRTI+GI G+++ID +GDR +Y + + ++VANY G Y V+G I W PP P CG+ + C N RK I G I+ + A L ++ Y++ K E + M W I ++V E S T+P +K Q S + ++ +PS TA+YKG + ++ ++ + +N LL E+K+ ++L + ++C+FIG L+ Q ++LTEYCPKGSLQDIL+NE I LDW FKFSL+ DI +GM YLH S + HG+L SS+C+VDSRFVLK+ DFGL +R E +D + LLW APE+LR++ I + K DVYSF II QEVVYR G FY+ + + P++IVE V P RP++ E C E L ++ W+E + RPDF I+ ++ + G S NILD+LLSRMEQYA NLEE+V++RT + EEK++ E LL MLP+SVA QLI +TV AE+Y+ V+IYFSDI GFTA+SA TPMQV+ +LN LYT FD+II+ +VYKVETIGDAYMV SGLP RNGD H +EIARMSLA + + F PH P +++ +RIG+HSGP AGVVGLKMPRYCLFGDTVNTASRMES GLPLKIH+S + +L TF+ F RG +++KGKG+ T+WL GED
Sbjct: 65 YHYVDDECNDLRGP-GKIAALYNRHKYSAFIGPSCSNVCAVTAKLAAFWNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTK--LGAFFVEICKQFGWQHIGIIYDGKPTWAIPVEGIKYQAEHNNITVAKYQDIHSSLSQGSTSNWSRVLN-EMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFE-----PYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFGT---YKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTINANDVIMMEHH-------SSTVPEKSHRSKPLQASLESIIC-----------------SMQDKPSAHR----------------------------TAVYKGTICSVSFVN-LRSTHLNSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQSPGSDPWT---ALLWRAPELLRQS--IPANGTQKGDVYSFAIIAQEVVYRRGPFYIPNSHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 1027
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 655.596 bits (1690), Expect = 0.000e+0 Identity = 401/1031 (38.89%), Postives = 570/1031 (55.29%), Query Frame = 2
Query: 284 YADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSEN-------YKN--KTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKND---TDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG----SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPN--RK--IGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRG-TKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGY 3310
Y D +C R P L + K + GP C A A+L FW+I +I+P A F + + Y TLTRV L F +I + + W + +IY+ G + +E+ Y++ + N +L +M ++V+ + VR +L++AHK NG++VF + QK + D D + AK+AY++L ++ +P + Y+ F + V +R+ +G E+ + + HD++ LYA ALN+T+A N +G +TR+MWNRTI+GI G+++ID +GDR +Y + + ++VANY G Y V+G I W PP P CG+ + C N RK I G I+ + A L ++ Y++ K E + M W I ++V E S T+P +K Q S + ++ +PS TA+YKG + ++ ++ + +N LL E+K+ ++L + ++C+FIG L+ Q ++LTEYCPKGSLQDIL+NE I LDW FKFSL+ DI +GM YLH S + HG+L SS+C+VDSRFVLK+ DFGL +R E +D + LLW APE+LR++ I + K DVYSF II QEVVYR G FY+ + + P++IVE V P RP++ E C E L ++ W+E + RPDF I+ ++ + G S NILD+LLSRMEQYA NLEE+V++RT + EEK++ E LL MLP+SVA QLI +TV AE+Y+ V+IYFSDI GFTA+SA TPMQV+ +LN LYT FD+II+ +VYKVETIGDAYMV SGLP RNGD H +EIARMSLA + + F PH P +++ +RIG+HSGP AGVVGLKMPRYCLFGDTVNTASRMES GLPLKIH+S + +L TF+ F RG +++K + +
Sbjct: 65 YHYVDDECNDLRGP-GKIAALYNRHKYSAFIGPSCSNVCAVTAKLAAFWNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTK--LGAFFVEICKQFGWQHIGIIYDGKPTWAIPVEGIKYQAEHNNITVAKYQDIHSSLSQGSTSNWSRVLN-EMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFE-----PYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFGT---YKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTINANDVIMMEHH-------SSTVPEKSHRSKPLQASLESIIC-----------------SMQDKPSAHR----------------------------TAVYKGTICSVSFVN-LRSTHLNSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQSPGSDPWT---ALLWRAPELLRQS--IPANGTQKGDVYSFAIIAQEVVYRRGPFYIPNSHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKVQSF 1017
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 578.941 bits (1491), Expect = 0.000e+0 Identity = 296/501 (59.08%), Postives = 369/501 (73.65%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGK 3304
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQDILENE INLDWMF+ SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E +D YA Y LWTAPE+LR T + K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP + + SE L ++ + W E+ RPDF IK + NK G S +ILDNLLSRMEQYANNLE+LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S + +VL F F + RG + MK K
Sbjct: 184 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRP-PAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQKVRNGQRPYFRPTV-DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 578.941 bits (1491), Expect = 0.000e+0 Identity = 296/501 (59.08%), Postives = 369/501 (73.65%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGK 3304
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQDILENE INLDWMF+ SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E +D YA Y LWTAPE+LR T + K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP + + SE L ++ + W E+ RPDF IK + NK G S +ILDNLLSRMEQYANNLE+LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S + +VL F F + RG + MK K
Sbjct: 54 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLR-MTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQKVRNGQRPYFRPTV-DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 296/501 (59.08%), Postives = 369/501 (73.65%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGK 3304
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQDILENE INLDWMF+ SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E +D YA Y LWTAPE+LR T + K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP + + SE L ++ + W E+ RPDF IK + NK G S +ILDNLLSRMEQYANNLE+LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S + +VL F F + RG + MK K
Sbjct: 139 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLR-MTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQKVRNGQRPYFRPTV-DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 296/501 (59.08%), Postives = 369/501 (73.65%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGK 3304
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQDILENE INLDWMF+ SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E +D YA Y LWTAPE+LR T + K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP + + SE L ++ + W E+ RPDF IK + NK G S +ILDNLLSRMEQYANNLE+LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S + +VL F F + RG + MK K
Sbjct: 107 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLR-MTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQKVRNGQRPYFRPTV-DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 296/501 (59.08%), Postives = 369/501 (73.65%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGK 3304
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQDILENE INLDWMF+ SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E +D YA Y LWTAPE+LR T + K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP + + SE L ++ + W E+ RPDF IK + NK G S +ILDNLLSRMEQYANNLE+LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S + +VL F F + RG + MK K
Sbjct: 212 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRP-PAPGTQKGDVYSFGIILQEIALRNGCFYIQGMDLSPKEIVQKVRNGQRPYFRPTV-DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371]) HSP 1 Score: 772.311 bits (1993), Expect = 0.000e+0 Identity = 431/1041 (41.40%), Postives = 609/1041 (58.50%), Query Frame = 2
Query: 290 DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRV--NSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSV-VLLNAETLLEID----------MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNN------QKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFA--LINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+A C + PL V L + P V+ GP C YS AP+ R W +P++T GA + +K +EY+ TR + + + D + L R++ W L+ L R F E + + + + +N + +E D + + V+ +C P++ R ++L A +YVF ++D+ +KPW + D +A++A+++ +T + P++ EY F+K++K ++K+ E N FHD LLLY A+ +T+A T +G IT++MWNR+ QG+TG + ID NGDR+ D+S+ DMD +TG F++V N+ G Q + V + W PPP P CG++ ++ + T+ ++ + L LI F+IY++++ + EL + W + W++++ L S R S RG S G ++ + + F TA YKGN+VA+K+++ K++E+ R +L E+K ++++ NEH+ RF+G C D P +LTEYCP+GSLQDILENE I LDWMF++SL DI +GM++LH+ IG HGNLKSSNC+VD RFVLKI D+GLE R + + + LWTAPE+LR + + S DVYSFGII QE+ R+GVFY+ ++L PK+I+E VT+ + P+RP + E L +++++ W ED RP F+ I+ +R NK +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H RE+ARM+LA L A+ F+I H+P +++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S ++ VL F F + RG V MKGKG TYWL GE
Sbjct: 83 NAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLT-AGAPALGIGVK-DEYALTTRTGPSHVKLGDFVTALHRRL----GWEHQALVLYADRLGDDRPC--FFIVEGLYMRVRERLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDR---RARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGS-----------RLTLSGRG---------------SNYGSLLTTEGQ-------------------------FQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASP-PARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEE-LGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0 Identity = 296/512 (57.81%), Postives = 374/512 (73.05%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNI-GPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILEN+ INLDWMF++SL+ D+ +GM +LH++I HG+LKSSNC+VDSRFVLKI D+GL R T E +D +A Y LWTAPE+L + KADVYSF II QE+ R+G FYL ++L PK+IV+ V Q +RP + ++ +E L ++ + W +D + RPDF IKG +R NK G + +ILDNLL RMEQYANNLE+LV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG H EIARM+LA L A+ F+I H+P+ ++ LRIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + D L F + RG V MKGKG TYWL GE
Sbjct: 535 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-NEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039 HSP 2 Score: 161.77 bits (408), Expect = 7.557e-40 Identity = 121/441 (27.44%), Postives = 204/441 (46.26%), Query Frame = 2
Query: 287 ADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIYEQTFLN---FCRSVGTLFDSENYKNKTFKSVVLLNAETLLEID---MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTN------NQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIG-KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFAL--INGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
++ D C PL V L + P + GP C Y A +AR W +P++T GA K+E Y TL R L + +NW +R L+Y + ++ +F++ N + + V E + + +V +C E + ILL+A + N NG+YVF +D+ +PW N T E +EA++++L +T + P + EY+ F + R E +G + N G F+D +LLYA LN+T+ T E+G I KM R G+TG + +D+N DR D+ + M D D+G F+ A+Y G +KQ++ G+ I WV K PP P C ++ + K T++++ + + F + ++ F I++++ + EL +M W I W+ ++
Sbjct: 69 SELDGACSEYLAPLR-AVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLT-AGAVASGFAAKNEHYRTLVRTGP--SAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW--TGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0 Identity = 296/512 (57.81%), Postives = 374/512 (73.05%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNI-GPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILEN+ INLDWMF++SL+ D+ +GM +LH++I HG+LKSSNC+VDSRFVLKI D+GL R T E +D +A Y LWTAPE+L + KADVYSF II QE+ R+G FYL ++L PK+IV+ V Q +RP + ++ +E L ++ + W +D + RPDF IKG +R NK G + +ILDNLL RMEQYANNLE+LV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG H EIARM+LA L A+ F+I H+P+ ++ LRIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + D L F + RG V MKGKG TYWL GE
Sbjct: 101 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-NEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 605
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025]) HSP 1 Score: 489.96 bits (1260), Expect = 6.317e-154 Identity = 341/1042 (32.73%), Postives = 518/1042 (49.71%), Query Frame = 2
Query: 374 FGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSV----GTLFDSENYK-NKTFKSVVLLNAETLLE---IDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPES----EEYRNFIKEVKNRT--NEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFI--TRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPV------EGQIIDWVNKKNLP------PPSFPVCGYNRKNCPNRK--IGAGTISLITMAAILLF------ALINGFYIYK-RVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINR-NLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQL-IPYRPFLSENEICSEG-LCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCE 3376
FGP C + I L W+IP+ G + + + T V + + + R+ + W + + + + V G + D + N T ++ LL+ +M V++L E RRIL A L GE+VFI + L W D+V + + Y S+ + + +R + + R S ++ + + HD+LLLYA + + + +G + T + T+QGITG + +D G R+ DYSV + + G + L++P + I W N N P P CG++ C + + T+++ + + F A I G +++ R K Q+ W I +D++ T +H+L+H+ + R S K + G +VK Q++ L F LY+GN VAL + + + + + EV + L +E+I F GVC + P ++T+YC KGSLQD++ N +DW+FK S DI G+++LH S + HGNLK SNCLVDS LK+ FGL + + + N E + L WTAPE+LR E + + DVYSF I+ ++++++ D+ P++I+ + + +P RP L E++ +G + ++R+ W E LRP F +IK +R + G +ILD+++ ++E YAN+LEE+V +RT + + EKRK E LL +MLP V QLI ++V E +E V+I+FSDIVGFT L + S+P+QV++LLN LY+ FD I+S DVYKVETIGDAYMV SGLP RNG H EIA M+L LS FQI H P +R++LRIG+H+GPV AGVVG+ MPRYCLFGDTVN ASRMES+ LPL+IH+S+ + L + + KRG +++KGKG QTT+WL G+D V P+PE E
Sbjct: 119 FGPACPEAAEVIGLLASEWNIPLFDFVGQMAALK----DHFWCDTCVTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNITASMRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFILLQQLEDSF-----WKEVLTKDKV-IRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQES-----------GNRSLFLPFLHYDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSI-TLLPQHKLSHRGTPV--------SRRNVSDTSTVKASAD----------CGSLVKRH--------------------QDEELF----FAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLR-LRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPRAPVPLRPSLLEDK--GDGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHV-SILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPV-PLPEFTE 1091
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 484.952 bits (1247), Expect = 9.946e-153 Identity = 243/436 (55.73%), Postives = 318/436 (72.94%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNI-GPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSG 3109
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILEN+ INLDWMF++SL+ D+ +GM +LH++I HG+LKSSNC+VDSRFVLKI D+GL R T E +D +A Y LWTAPE+L + KADVYSF II QE+ R+G FYL ++L PK+IV+ V Q +RP + ++ +E L ++ + W +D + RPDF IKG +R NK G + +ILDNLL RMEQYANNLE+LV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG H EIARM+LA L A+ F+I H+P+ ++ LRIG+H+G
Sbjct: 535 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-NEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963 HSP 2 Score: 161.77 bits (408), Expect = 8.433e-40 Identity = 121/441 (27.44%), Postives = 204/441 (46.26%), Query Frame = 2
Query: 287 ADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIYEQTFLN---FCRSVGTLFDSENYKNKTFKSVVLLNAETLLEID---MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTN------NQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIG-KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFAL--INGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
++ D C PL V L + P + GP C Y A +AR W +P++T GA K+E Y TL R L + +NW +R L+Y + ++ +F++ N + + V E + + +V +C E + ILL+A + N NG+YVF +D+ +PW N T E +EA++++L +T + P + EY+ F + R E +G + N G F+D +LLYA LN+T+ T E+G I KM R G+TG + +D+N DR D+ + M D D+G F+ A+Y G +KQ++ G+ I WV K PP P C ++ + K T++++ + + F + ++ F I++++ + EL +M W I W+ ++
Sbjct: 69 SELDGACSEYLAPLR-AVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLT-AGAVASGFAAKNEHYRTLVRTGP--SAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW--TGRPIPWV--KGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2) HSP 1 Score: 772.311 bits (1993), Expect = 0.000e+0 Identity = 431/1041 (41.40%), Postives = 609/1041 (58.50%), Query Frame = 2
Query: 290 DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRV--NSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSV-VLLNAETLLEID----------MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNN------QKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFA--LINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+A C + PL V L + P V+ GP C YS AP+ R W +P++T GA + +K +EY+ TR + + + D + L R++ W L+ L R F E + + + + +N + +E D + + V+ +C P++ R ++L A +YVF ++D+ +KPW + D +A++A+++ +T + P++ EY F+K++K ++K+ E N FHD LLLY A+ +T+A T +G IT++MWNR+ QG+TG + ID NGDR+ D+S+ DMD +TG F++V N+ G Q + V + W PPP P CG++ ++ + T+ ++ + L LI F+IY++++ + EL + W + W++++ L S R S RG S G ++ + + F TA YKGN+VA+K+++ K++E+ R +L E+K ++++ NEH+ RF+G C D P +LTEYCP+GSLQDILENE I LDWMF++SL DI +GM++LH+ IG HGNLKSSNC+VD RFVLKI D+GLE R + + + LWTAPE+LR + + S DVYSFGII QE+ R+GVFY+ ++L PK+I+E VT+ + P+RP + E L +++++ W ED RP F+ I+ +R NK +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H RE+ARM+LA L A+ F+I H+P +++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG L+IH+S ++ VL F F + RG V MKGKG TYWL GE
Sbjct: 83 NAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLT-AGAPALGIGVK-DEYALTTRTGPSHVKLGDFVTALHRRL----GWEHQALVLYADRLGDDRPC--FFIVEGLYMRVRERLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDR---RARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGS-----------RLTLSGRG---------------SNYGSLLTTEGQ-------------------------FQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASP-PARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEE-LGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1) HSP 1 Score: 771.541 bits (1991), Expect = 0.000e+0 Identity = 434/1041 (41.69%), Postives = 612/1041 (58.79%), Query Frame = 2
Query: 290 DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRV--NSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSV-VLLNAETLLEID----------MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNN------QKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAIL--LFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+A C + PL V L + P V+ GP C YS AP+ R W +P++T GA + +K +EY+ TR + + + D + L R++ W L+ L R F E + + + + +N + +E D + + V+ +C P++ R ++L A +YVF ++D+ + QKPW + D A++A+++ +T + P++ EY F+K++K ++K+ +VE+ N FHD LLLY A+ +T+A T +G IT++MWNR+ QG+TG + ID NGDR+ D+S+ DMD +TG F++V NY G Q + V + W PPP P CG++ ++ + T+ ++ + L + LI F+IY++++ + EL + W + W++++ L S R S RG S G ++ + + F TA YKGN+VA+K+++ K++E+ R +L E+K ++++ NEH+ RF+G C D P +LTEYCP+GSLQDILENE I LDWMF++SL DI +GM++LH+ I HGNLKSSNC+VD RFVLKI D+GLE R + + + LWTAPE+LR + + S DVYSFGII QE+ R+GVFY+ ++L PK+I+E VT+ + P+RP + E L +++++ W ED RP F+ I+ +R NK +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H RE+ARM+LA L A+ F+I H+P +++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S ++ VL F F + RG V MKGKG TYWL GE
Sbjct: 83 NAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLT-AGAPALGIGVK-DEYALTTRTGPSHVKLGDFVTALHRRL----GWEHQALVLYADRLGDDRPC--FFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDR---SARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYW--PLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGS-----------RLTLSGRG---------------SNYGSLLTTEGQ-------------------------FQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASP-PARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEE-LGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1) HSP 1 Score: 770 bits (1987), Expect = 0.000e+0 Identity = 435/1034 (42.07%), Postives = 608/1034 (58.80%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNS--IIVTDHLKVLFRKIFQMYNWSRVKLI---YEQTFLNFCRSV--GTLFDSENYKNKTFKSVVL----LNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNN------QKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAIL--LFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
C + PL V L + P V+ GP C Y+ AP+ R W +P++T GA + +K +EY+ TR + D + L R++ W R L+ Y C + G + N T + L+ T L M + V+ +C P++ R ++L A + +YVF ++D+ ++PW + D +V+ A++A+++ +T + P++ EY F+K++K+ E++ E N FHD LLLY A+ +T+A T +G IT++MWNR+ QG+TG + ID +GDR D+S+ DMD + G F++V NY G Q + V G+ ++W PPP P CG++ ++ + T+ ++ + L L LI F+IY++++ + EL + W + W++VE L S R S RG S G ++ + + F TA YKGN+VA+K+++ K++E+ R +L E+K ++++ NEH+ RF+G C D P +LTEYCP+GSLQDILENE I LDWMF++SL DI +GM++LH+ I HGNLKSSNC+VD RFVLKI D+GLE R L + Y LWTAPE+LR + ++ S DVYSFGII QE+ R+GVF++ ++L PK+I+E VT+ + P+RP L+ E L ++++ W ED RP F+ I+ +R N+ +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H E+ARM+LA L A+ F+I H+P +++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S ++ VL F F + RG V MKGKG TYWL GE
Sbjct: 92 CSDTAAPLA-AVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLT-AGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRL----GWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW-ERGDGQDVS--ARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGS-----------RLTLSGRG---------------SNYGSLLTTEGQ-------------------------FQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD----LDPEQGHTVYAKKLWTAPELLRMASP-PVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEE-LGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P55202|ANPRB_ANGJA (Atrial natriuretic peptide receptor 2 OS=Anguilla japonica OX=7937 GN=npr2 PE=2 SV=1) HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0 Identity = 422/1027 (41.09%), Postives = 584/1027 (56.86%), Query Frame = 2
Query: 359 KPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKL---------------IYEQTFLNFCRSVGTL--FDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKT--NNQKPWYSK--NDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGA-GTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKST-KADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
KP +FGP C YS+A + R + W +P+IT + F EEY T+ R + T L + +NW+ I E FL R T+ ++ KN ++ ++ + S +V +C ++ + +Y +D+ + KPW S N TD + ++S+ +TA+ P++ EY+ F +E+ R +++ +E S + G F+D +LYA ALN+T+A + +G IT+KM NR G+TG +S D+N DR+ D+++ M + TG + IVA Y G + + E + I W K PP P C ++ C ++ G +++ + A+++F I+ F IY+++K + EL M W I W+ + E+ K H+ R S+RG S G ++ + + F T +KGN+VA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILENE INLDWMF++SL+ DI +GM +LH S IG HGNLKSSNC+VDSRFVLKI D+GL R + E D +A Y LWTAPE+L + H + T K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP ++ SE L ++ W ED + RPDF IK + LNK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV S RNG +H REIA MSLA L + F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + +VL F F + RG V MKGKG TYWL GE +
Sbjct: 101 KPDAFFGPGCVYSVASVGRFVNHWKLPLITAWAPAFGFDS--KEEYRTIVRTG--LSTTKLGEFAHYLHSHFNWTTRAFMLFHDLKVDDRPYYFISEGVFLVLRRENITVEAVPYDDQKNSDYREMI---------SSLKSNGRIVYICGPLDTFLEFMRIFQNEGLPPEDYAIFYLDMFAKSILDKDYKPWESSDINWTDPIKL-----FKSVFVITAKEPDNPEYKAFQRELHARAKQEFSVQLEPSLEDIIAGCFYDGFMLYAQALNETLAEGGSQNDGINITQKMQNRRFWGVTGLVSTDKNNDRDIDFNLWAMTNHKTGQYGIVAYYNGTNKEIVWSETEKIQW--PKGSPPLDNPPCVFSMDEPFCNEDQLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRIRWEELQFESPNKYHKCA-------------GSRLTISQRG---------------SSYGSLITAHGK-------------------------YQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NEDSHALYAKKLWTAPELL--IYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVDGMDLSPKEIVQKVRNGQKPYFRP-TTDTSCHSEELSILMEGCWAEDPADRPDFSYIKIFVMKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSDSQSRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWLLGEKT 1045
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P46197|ANPRB_BOVIN (Atrial natriuretic peptide receptor 2 OS=Bos taurus OX=9913 GN=NPR2 PE=2 SV=1) HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0 Identity = 297/512 (58.01%), Postives = 375/512 (73.24%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNI-GPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F T +KGNVVA+K ++ K++E+ R +L E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILEN+ INLDWMF++SL+ D+ +GM +LH++I HG+LKSSNC+VDSRFVLKI D+GL R T E +D +A Y LWTAPE+L + KADVYSFGII QE+ R+G FYL ++L PK+IV+ V Q +RP + ++ +E L ++ + W +D + RPDF IKG +R NK G + +ILDNLL RMEQYANNLE+LV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG H EIARM+LA L A+ F+I H+P+ ++ LRIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + D L F + RG V MKGKG TYWL GE
Sbjct: 535 QIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIASHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELL-SGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-NEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039 HSP 2 Score: 157.918 bits (398), Expect = 9.361e-38 Identity = 119/441 (26.98%), Postives = 205/441 (46.49%), Query Frame = 2
Query: 287 ADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIYEQTFLN---FCRSVGTLFDSENYKNKTFKSVVLLNAETLLEID---MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSK------TNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIG-KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFAL--INGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
++ D C PL V L + P + GP C Y A +AR W +P++T + F K E Y TL R L + +NW +R L+Y + ++ +F++ N + + V E + + +V +C E + ILL+A + N NG+YVF +D+ + +PW N T E +EA++++L +T + P + EY+ F + R E +G + N G F+D +LLYA LN+T+ T E+G I KM R +G+TG + +D+N DR D+ + M D +G F+ A+Y G +KQ++ G+ I WV K +PP P C ++ + K T++++ + + F + ++ F I++++ + EL +M W I W+ ++
Sbjct: 69 SELDGACSEYLAPLR-AVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF-SAKSEHYRTLVRTGP--SAPKLGEFVVMLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRSMGRPW-QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYRGVTGLVVMDKNNDRETDFVLWAMGDLVSGDFQPAAHYSGAEKQIWW--TGRPIPWV--KGVPPLDNPPCAFDMDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ 500
BLAST of Guanylate cyclase vs. TrEMBL
Match: G4V651 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 GN=Smp_142620 PE=3 SV=1) HSP 1 Score: 1039.25 bits (2686), Expect = 0.000e+0 Identity = 536/1030 (52.04%), Postives = 688/1030 (66.80%), Query Frame = 2
Query: 368 VWFGPICDYSLAPIARL-LPFWDIPIITPCGASGIFRQMKHE-EYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-----SRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSE--------------NAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRK-IGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRK-TTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDI-NLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCE 3376
V FGP+ D++LA AR +++PI+ P +G Q+ + EY LTRV + L+ +F + Y W + + ++ + VG + +++ + ++ A LL + + E +++LC +PE VR I+L+AHKLN +NG+Y F N+DLL+S+T ++PWY + + E N +A++AYR+L+TVT +P+S EYR F +EV+ R Y E F+G FHD++ LYALALND +A T NGT IT++MWNRT +G+TG + ID NGDRNADYS+LDM+ TG F++V NY G + V G+ IDW+N N PP P CG++ C N I G + + ++ +L+ G Y+R KFQAEL AMNW+IPWD ++ EK L ++ ESD I +P+ + D ++ S E+ T ++ + F TA Y ++VALK L ++E ++ L IEVKKVK+LN +HICR IGVCL+ P ++ EYCPKGSLQD+LENEQI LDWMFKFSL+QDICRG++YLH GPHGNLKSSNCLVDSRFVLKI DFGL +RG E + ++RNLLWTAPE+L T I+ ++S K DVYSF I+CQE+VYR GVFY+ + N EP IV+ V + P+RP L E CSE L ++I Q+W +D S+RPDF++IK MR LNK GDS N+LDNLLSRMEQYANNLEELV QRT QYLEEK+KTEDLLYSMLP+SVA QL RN+ VTAES+EMV+IYFSDIVGFT+LSAESTPMQV+ELLNRLYT FD IIE+FD YKVETIGDAYMV SGLPQRNG+ H RE+ARMS+AFL AIFEFQIPH+P KR+ELRIGIHSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S+Q+ DVL+TF+ FI+++RG V MKGKG Q TYWLHGED IVDPIP +
Sbjct: 147 VIFGPLNDFTLANAARFSTAMYNVPIVAP---AGFAHQLSDKLEYGMLTRV--LFTYSDLEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDVTDRFLKRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEYRTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKH---------------------------LRRYRRESD--IRSPNQSSDPLRKISS------------ETCTAAAANS----QMFARTAFYMKSIVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLESEVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKPPFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIPPGAQ 1126
BLAST of Guanylate cyclase vs. TrEMBL
Match: V4BNJ3 (Guanylate cyclase (Fragment) OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_191857 PE=3 SV=1) HSP 1 Score: 956.051 bits (2470), Expect = 0.000e+0 Identity = 510/1044 (48.85%), Postives = 666/1044 (63.79%), Query Frame = 2
Query: 293 ADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIY------------------EQTFLNFCRSVGTL-----FDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSV----EESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRK-IGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYL-HSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
ADS+C + PL + MK V+ GP CDY++APIAR WDIPII+ G F K EY LTRV F + Q + W+RV L Y E ++ + G FD +N + + +L E + V+VLC P++VR I++KAH+LNF NGEYVF NIDL +SK +++PWY +NDT+E N KA++AY +L+TVT ++P S EYR F +EVK R Y + EE N F+G FHD++LLY+LALN+T+ N++ NG+ IT++MWNRT +GITG +SID NGDRNADYS+LDM+ + F++VANY G K+ Y PV G+ I W PPP P CG++ CP + I +I + +I+L LI F+IY+ +K +AEL MNW + W+ D++ G+P ++ + SRV+ L ++NL ++++++++G +VA+K++ + I + LL+E+K++K+L N+H RFIG C+D +LTEYCPKGSLQD+LENEQI LDWMF++S++QDI RGM YL + I HGNLKS+NC+VDSRFV+KI DFGL LR E E D +A Y LWTAPE+LR + + K DVYSF IICQE+VYR GVFYL++++L P++I + V +RP L E + + L +IR+ W ED RPDF +K ++R LNK GD GNILDNLLSRMEQYANNLE LV +RT YLEEKRK EDLLYSMLPK VAGQLIR E+V AES+E V+IYFSDI GFTALSA STPMQVI+LLN LYTTFDSIIE FDVYKVETIGDAYMV SGLP RNG++H RE+ARMSLA L+A+ F+I H+PN++++LRIGIH+G V AGVVGLKMPRYCLFGDTVNT+SRMESNGLPL+IH+S Q+ +VL F F + RG+V MKGKG TTYWL+GE
Sbjct: 72 ADSNCSETLGPL---AAIDMKESVHVFIGPACDYAVAPIARFSYAWDIPIISGGAMVGAFENKK--EYKLLTRVMGPYA--RAGDFFFTMCQNFQWNRVGLWYHNYPPGSTKGKSNCFFALEAIYMKWQTMYGVEVWNRDFDEDNVRPGDHEKTLLQAKENI---------RVIVLCASPDAVRNIMIKAHELNFDNGEYVFFNIDLFSSKNASERPWYRENDTEERNDKARKAYDALMTVTLRKPNSPEYRMFSEEVKKRAKTMYNNFTYGEEEVNSFVGAFHDAVLLYSLALNETLEANISISNGSHITQRMWNRTFEGITGTVSIDANGDRNADYSLLDMNPENSKFEVVANYYGNKKKYEPVVGKDIHWAGGLTSPPPDTPTCGFDGSKCPPEEPFPEYGIVIIVLGSIILIVLIAAFFIYRHIKLEAELAEMNWRVRWE-------------------------------------------DIIFGSPE-KNHKLERQGSRVSLNR---------VKLDSNNL-----YLSSSVFQGAIVAIKKID-RHSITIQKPLLLEIKRIKDLQNDHTVRFIGACIDPSNLCVLTEYCPKGSLQDVLENEQIKLDWMFRYSIMQDIVRGMTYLTGTEIKSHGNLKSTNCVVDSRFVVKITDFGLHHLRSQTEGP-EEDTFAAYNRKLWTAPELLRMQHRPP-EGTHKGDVYSFAIICQEIVYRMGVFYLANLDLSPQEIFDKVKNGMKPYFRPTLEEFDCPCDELAGVIRKCWAEDPLERPDFPALKSIIRKLNKDGDKGNILDNLLSRMEQYANNLEALVAERTSDYLEEKRKAEDLLYSMLPKVVAGQLIRGESVAAESFESVTIYFSDICGFTALSAASTPMQVIDLLNDLYTTFDSIIEHFDVYKVETIGDAYMVVSGLPVRNGNLHAREVARMSLALLNAVLSFKIRHRPNEQLKLRIGIHTGYVVAGVVGLKMPRYCLFGDTVNTSSRMESNGLPLRIHVSPQTKEVLDNFGTFDLELRGEVEMKGKGKVTTYWLNGE 1038
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A210PTL8 (Guanylate cyclase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT22877 PE=3 SV=1) HSP 1 Score: 952.199 bits (2460), Expect = 0.000e+0 Identity = 506/1049 (48.24%), Postives = 672/1049 (64.06%), Query Frame = 2
Query: 296 DSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTF-------LNFCRSVGTLFD---------------SENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEK-----YGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCP-NRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYL-HSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHL---QKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPY-RPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
DS+C + PL + L + V+FGP+CDY++APIAR +W+IP+I+ F EY LTR+ + VL ++ + +NW+ V L + + N +V +F EN+ N+ +LL A T I VVLC +SVR I++KAH+LNF NGEYVF+NIDL +SK ++KPWY ++DT E N KA++AY +L+TVT ++P S EY++F +EVK R K YG EE N F+G FHD+++LYA+ALN+T+ NL+ NGT IT+ MWNRT GITG +SID+NGDRNADYS+LDM+ G F++VANY G + Y P + I W +N PPP P CG++ CP + I +I + ++L+ L+ F+IY+ +K +AEL MNW + W+++ + E +L + S N ++ + + + + D + S V + F T YKG ++A+K +H + + +N+ LLIEVK++K+L N+HI RFIG C+D P +LTEYC KGSLQD+LENEQI LDWMF++SL+QDI RGM YL +S+I HGN+KS+NC+VD RFVLKI DFGL LRG + + E YA+YR LWTAPE+LR +H + + K DVYSF IICQE+VYR+GVFYL++++L P++I + V K L PY RP L E + + L +IR+ W ED RPDF+ +K +R LNK GD GNILDNLLSRMEQYANNLE LV +RT YLE+K+K EDLLY MLPKSVA L+R E AE+Y V+IYFSDI GFTA+S+ESTPMQV++LLN LYT FDS+IE+FDVYKVETIGDAYMV SGLP RNG++H REIARMS++ L+A F+I H+PN++++LRIGIH+GPV AGVVGLKMPRYCLFGDTVNT SRMESNGLPL+IH+S + +VL TF F + RG V MKGKG TYWL GE
Sbjct: 92 DSECSETIGPLK-AIDLYVDRDVDVFFGPVCDYAVAPIARFSGYWNIPVISAGATVKAFDN--KTEYRLLTRIQGAYAKNAEFVL--EVAKAFNWTNVGLFFHENMGGGRKGKSNCYFTVEPIFYKLKNQLKFQPKYEQFDENFPNEYDFGELLLKASTYTRI--------VVLCASADSVRDIMIKAHELNFDNGEYVFLNIDLFSSKNESEKPWYREDDTAERNEKARKAYEALMTVTLRKPTSPEYKHFSEEVKKRAESKDRNFTYGE-EEVNSFVGAFHDAVILYAIALNETLTRNLSITNGTEITKLMWNRTFDGITGTVSIDDNGDRNADYSLLDMNPKNGKFEVVANYYGNNKEYKPEPDKKIYWAGGRNSPPPDTPTCGFDGSKCPPSEPFPEYGIVIIVLGSLLVIVLVTAFFIYRHIKLEAELAEMNWRVRWEDIMFGSMENDKKLKRQGSSVSLNRKMS---------------------LASSTCSVDTIAVHLSDVGQR---------------------QLFTKTGYYKGAIMAIKSIHKTS-LTVNKPLLIEVKRIKDLQNDHIVRFIGACIDPPNMCILTEYCQKGSLQDVLENEQIKLDWMFRYSLMQDILRGMTYLFNSDIRSHGNMKSTNCVVDGRFVLKITDFGLHALRGPPDDV-EEGMYAFYRTQLWTAPELLR----MHYRPPEGTQKGDVYSFAIICQEIVYRSGVFYLANLDLSPEEIHQKV-KNGLKPYFRPTLEEADCPCDELAEVIRKCWSEDPMERPDFQALKSTIRKLNKDGDKGNILDNLLSRMEQYANNLEALVEERTSDYLEQKKKAEDLLYMMLPKSVACNLMRGEICHAETYNCVTIYFSDICGFTAMSSESTPMQVVQLLNDLYTAFDSVIENFDVYKVETIGDAYMVVSGLPMRNGNLHAREIARMSISLLNATMSFKIRHRPNEQLKLRIGIHTGPVVAGVVGLKMPRYCLFGDTVNTTSRMESNGLPLRIHVSPCTKEVLDTFTTFDLELRGPVEMKGKGTVITYWLKGE 1077
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 950.658 bits (2456), Expect = 0.000e+0 Identity = 519/1084 (47.88%), Postives = 690/1084 (63.65%), Query Frame = 2
Query: 296 DSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARL--LPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW----------------------SRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEI--DMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSV---EESNKFLGVFHDSLLLYALALNDTMAMNLTYE-------NGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK--RHRLTHKVS------DTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVK----------SRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEND-EYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINL-EPKQIVEFVTKVQLIPYRPFLSE-----NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPI 3361
DS C S P+ LL++ K + GP C ++LA +AR +P + PI+T G + R EY L RV D ++ + +FQ +NW +R ++ Q+ + C + F E Y + + + NA+ EI M E +VVLC +P++VR I++KA +L FINGEYVF NIDL +S+ +PW +NDT E N KA AYR+L+T+T ++P S EYRNF ++VK+ KY EE N F+G FHD+++LYALA+NDT+ YE NG+ IT KM NRT +GITG +SI+ NGDR+ADYS+LDMDK+T F +VA+Y G +Q Y V G+ IDW N+ NLPP P CG++ C T +++ + ++ + IY++++ ++EL+AMNW IPW +E E+ R T + D P + Q+ + K + +L GN G K + S + +S+ S ++ G+ + + F TA YKG +VALK L +K++E+ LL+EVK+VK+L ++++ RFIG CLDAP L++EYCPKGSLQD+LEN+ +NLDWMFKFSL+ DICRGMIYLH N G HGNLKSSNCLVDSRF LKI DFGL+ LRGTK+Y + D EY+ YRN LWTAPE+LR T + + + DVYSF IICQE++YR GVF++SD + EP++IVE V ++ YRP L ++ SE L +R WQED + RP F +IK + NK +SGNILDNLL RMEQY+NNLE LV +RT+ YLEEK+K E+LLY MLPKSVA L+R E+VTAE ++ V+IYFSDI GFTALS+ESTP++V+ LLN LYT FD IIE +D YKVETIGDAYMV SGLP RNG +H REI+RM+L+FL I+ F+I HKP+ +++LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIH+S + ++L F+ + RG+V MKGKG Q TYWLHGE IVDP+
Sbjct: 34 DSKCDYSVAPVLGV--LLLQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRD--KAEYFNLIRVGPSF--DGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRI-LCHGIEKHFVQEKYIVRRLQ-YEMHNAQFKSEIFRVMRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTV-----YEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPP-EGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPV 1103
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8JDN4 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 949.503 bits (2453), Expect = 0.000e+0 Identity = 509/1059 (48.06%), Postives = 678/1059 (64.02%), Query Frame = 2
Query: 377 GPICDYSLAPIARLLPFW--DIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-----SRVKLIY------------EQTFLNFCRSVGTLFDSE--------------NYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMN--LTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK-----------RHRLTHKVSDT-LPNSELFTKRFQYSKRG--LAKFDEESDVLIGNPSLA---GDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLH-GSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLEND-EYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINL-EPKQIVEFVTKV--QLIPYRPFLSENEICSEG-----LCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDP 3358
GP C + LA +AR ++ PIIT A+ + EEY L RV + ++ + IFQ YNW + +IY ++T + F R + T ++ + NK F+S V M E +VVLC +P++VR I++KAH+L FINGEYVF NIDL +S+ +PWY K D++E N A AYR+L+T+T ++P S EYR+F +VK + Y EE N F+G FHD++LLYALA+NDT+A + NG+ IT +M +RT +GITG +SI+ NGDRNADYS+LDMDK+T F +VA+Y G + Y V G++IDW +K NLPPP P CG++ C ++I + ++ + IY++++ ++EL+AMNW I W +E E+ RL + SD+ ++ F Q + L E +P++A DVV S S E+ G+ + + F TA YKGN+VALKQ++ +K++E+N +L+E+K+VK+L +++I RFIG CLD+P L+TEYCPKGSLQDILEN+ +NLDWMFKFSL+ DICRGMIYLH + G HGNLKSSNCLVDSRF LKI DFGL LRG+KE +D +Y+ YRN LWTAPE+LR + + + + DVYSFGII QE++YR GVFY+SD + EP+ I+E + + P+RP LS+ + +G L I+R W ED + RP+F +K + NK +SGNILDNLL RMEQY+NNLE LV +RT+QYLEEK+K E+LLY MLPK VA L++ E+VTAE ++ V+IYFSDI GFTALS+ESTPM+V+ LLN LYT FD IIE +D YKVETIGDAYMV SGLP RNG++H REIARMSL+FL IF F+I HKP+ +++LRIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIH+S + +L F+ ++RG+V MKGKG Q TYWLHGE+ IVDP
Sbjct: 37 GPFCTFCLAAVARYNRYYLYQKPIITSGAAANL---EDKEEYYNLIRVGPMNF--DIENMLLAIFQRYNWLPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVKPYSATNKHFQSEVFRC--------MREEVRLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGVIYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNEQQQQDEDPAIAPKGSDVVSSNDS-----------VETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 657.522 bits (1695), Expect = 0.000e+0 Identity = 389/953 (40.82%), Postives = 553/953 (58.03%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCR----SVGTLFDSENYKNKTFKSVVL-LNAETLLEIDM----GSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLL--TSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGF--YIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSG 3109
C S PL V L P + GP CDY+ +P+AR W++P++T GA + M YS++T N+ L ++ + W + ++ N R +V + N T K +V + E L D+ VV +C + ++ R+++++ +K EYVF IDL + ++ KPW + DE AK+A++S+ +T + P++ EY++F+ ++K +++ S+E+S N G FHD +LLY+ ALN++M + G +T+KMWNRT G+TG + +DENGDR D+++ DM D ++G+++IV+ Y + + G + W+ K PPP PVCG+ N +I++ A +F +I +IY++VK + EL A W + W++++ L S R S RG +++ S L+ + ++ + T YKGN+ A+K ++ K++E+ R +L E+K ++++ NEH+ RFIG C+DAP +LTEYCP+GSLQD++E E I LDWMF++SL+ DI +GM +LH S I HGNLKSSNCLVDSRFVLKI D+GL R KE LE D +AYY LWTAPE++R + K DVYSFGII QE+ GVFYL PK+IVE V + + RP L + SE L +++++ W ED + RPDF IK M+ N+G S NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTA+SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H EIARMSLA L A++ F+I H+P+ ++ LRIGIH+G
Sbjct: 105 CSDSVAPLV-AVDLKFAHDPWAFIGPGCDYASSPVARFTTHWEVPMVT-AGAPALGFNM----YSSIT--NTGPTHKKLGEFVVRMHHNFGWHKYAMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLSYADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEA---AKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEIVSVYNSSAKQMVLEPGMKVHWL--KGSPPPDIPVCGFKNDNPACLAKTVTMHQMISIVACFIFIIIVTVTVFIYRKVKLENELAAQLWRVYWEDIQISNLDKALRRACS-----------RLTLSLRG------------------------------------SNYGSLLTLEGN----VQIYAKTCYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYLE-DTHAYYARKLWTAPELMRDENR-QPCGTQKGDVYSFGIILQELALLKGVFYLDSPPFSPKEIVEHVAEGRWPYLRPLLC-TQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTG 986
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 599.742 bits (1545), Expect = 0.000e+0 Identity = 307/515 (59.61%), Postives = 379/515 (73.59%), Query Frame = 2
Query: 1802 IKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
++ + T YKGN+ A+K ++ K++E+ R +L E+K ++++ NEH+ RFIG C+DAP +LTEYCP+GSLQD++E E I LDWMF++SL+ DI +GM +LH S I HGNLKSSNCLVDSRFVLKI D+GL R KE LE D +AYY LWTAPE++R + K DVYSFGII QE+ GVFYL PK+IVE V + + RP L + SE L +++++ W ED + RPDF IK M+ N+G S NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTA+SAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H EIARMSLA L A++ F+I H+P+ ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+SE + VL+ F F + RG + MKGKG TYWL GE +
Sbjct: 542 VQIYAKTCYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYLE-DTHAYYARKLWTAPELMRDENR-QPCGTQKGDVYSFGIILQELALLKGVFYLDSPPFSPKEIVEHVAEGRWPYLRPLLC-TQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGEST 1049 HSP 2 Score: 152.525 bits (384), Expect = 5.495e-37 Identity = 101/336 (30.06%), Postives = 175/336 (52.08%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCR----SVGTLFDSENYKNKTFKSVVL-LNAETLLEIDM----GSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLL--TSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKI 1267
C S PL V L P + GP CDY+ +P+AR W++P++T GA + M YS++T N+ L ++ + W + ++ N R +V + N T K +V + E L D+ VV +C + ++ R+++++ +K EYVF IDL + ++ KPW + DE AK+A++S+ +T + P++ EY++F+ ++K +++ S+E+S N G FHD +LLY+ ALN++M + G +T+KMWNRT G+TG + +DENGDR D+++ DM D ++G++++
Sbjct: 82 CSDSVAPLV-AVDLKFAHDPWAFIGPGCDYASSPVARFTTHWEVPMVT-AGAPALGFNM----YSSIT--NTGPTHKKLGEFVVRMHHNFGWHKYAMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLSYADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEA---AKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEV 406
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 596.66 bits (1537), Expect = 0.000e+0 Identity = 301/512 (58.79%), Postives = 383/512 (74.80%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F TA +KGN+VA+K ++ K++E+ R +L E+K ++++ N+H+ RFIG C+D P ++TEYCP+GSLQDILENE I LDWMFK+SL+ DI +GM +LH S I HGNLKSSNC+VD+RFVLKI D+GL R + D ++YY LW AP++LR + + K D+YSFGII QEV R GVFY+ +L PK+IV+ V + RP ++ + SE L +++++ W E+ + RP+F IK ++R N+ S +ILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+P+++++LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG PLKIH+S S D+L+ F F + RG V MKGKG TYWL GE
Sbjct: 563 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPAC-GTQKGDIYSFGIILQEVALRRGVFYIEGDSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1067 HSP 2 Score: 182.956 bits (463), Expect = 1.650e-46 Identity = 127/445 (28.54%), Postives = 215/445 (48.31%), Query Frame = 2
Query: 290 DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKN-----KTFKSVVLLNAETLLEID------------MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQ--KPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
+ D C S PL V L +P + GP CDY+ +P+ W +P+IT GA + + + Y+++T N+ L I + + WS + L F S + + E Y K V + + + E D + E VV +C P+ R++++ K N E+VFI ID+ +Q +PW + DE+ AK+AY+S+ +T + P++ EY++F+ ++K + + +V++S N G F+D L+LY ALN+++A + + IT +MWNRT G+TG + ID++GDR D+++ DM D ++ +F+IVA Y G ++ + G W PP P CG+ N C R I + I + IL+ +IY+++K + EL A W I W++++
Sbjct: 101 NTDGICSESIAPLM-AVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMIT-AGAPAVGFSDRSDAYTSIT--NTGPTHKKLGEFALHICRHFGWS------QHALLMFGDS--KMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDEL---AKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHW--PGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQ 528
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 596.66 bits (1537), Expect = 0.000e+0 Identity = 301/512 (58.79%), Postives = 383/512 (74.80%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+ F TA +KGN+VA+K ++ K++E+ R +L E+K ++++ N+H+ RFIG C+D P ++TEYCP+GSLQDILENE I LDWMFK+SL+ DI +GM +LH S I HGNLKSSNC+VD+RFVLKI D+GL R + D ++YY LW AP++LR + + K D+YSFGII QEV R GVFY+ +L PK+IV+ V + RP ++ + SE L +++++ W E+ + RP+F IK ++R N+ S +ILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIARMSLA L A+ F+I H+P+++++LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG PLKIH+S S D+L+ F F + RG V MKGKG TYWL GE
Sbjct: 563 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPAC-GTQKGDIYSFGIILQEVALRRGVFYIEGDSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1067 HSP 2 Score: 182.956 bits (463), Expect = 1.650e-46 Identity = 127/445 (28.54%), Postives = 215/445 (48.31%), Query Frame = 2
Query: 290 DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKN-----KTFKSVVLLNAETLLEID------------MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQ--KPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
+ D C S PL V L +P + GP CDY+ +P+ W +P+IT GA + + + Y+++T N+ L I + + WS + L F S + + E Y K V + + + E D + E VV +C P+ R++++ K N E+VFI ID+ +Q +PW + DE+ AK+AY+S+ +T + P++ EY++F+ ++K + + +V++S N G F+D L+LY ALN+++A + + IT +MWNRT G+TG + ID++GDR D+++ DM D ++ +F+IVA Y G ++ + G W PP P CG+ N C R I + I + IL+ +IY+++K + EL A W I W++++
Sbjct: 101 NTDGICSESIAPLM-AVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMIT-AGAPAVGFSDRSDAYTSIT--NTGPTHKKLGEFALHICRHFGWS------QHALLMFGDS--KMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDEL---AKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHW--PGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQ 528
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2]) HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0 Identity = 376/1023 (36.75%), Postives = 537/1023 (52.49%), Query Frame = 2
Query: 359 KPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIY---------------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQ--KPWYSKNDTDEVNFKAK-EAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIG-KKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIV 3352
+P + GP C YS+A + R W +P+IT G + F EE+ TL R T L + +NW+R L+ E ++N T+ N +++ +V E+ +V +C ++ I+ + +Y +D +N+ +PW+ T + +K + ++++ +T + P++ EY F E+ R + + +E S + G F+D +LYA ALN+ +A ++ +G IT +M NR+I G+TG +S D+N R D+S+ M T + +Y G K++ +G I W + P V +C R + +LLF + +++K + EL M W I W+++ E+ K H+ R S+RG S G ++ + + F T +KGN+VA+K ++ K++E+ R +L E+K ++++ H+ RF+G C+D P ++TEYCP+GSLQ ++ +LL GM YLH S IG HGNLKSSNC+VDSRFVLKI D+GL R + + D + Y LWTAPE+L Q + K D+YSFGII QE+ RNG FY+ ++L PK+I++ V Q +RP + C E L ++ W ED + RPDF IK + LNK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKR+ E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT+ V+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIA MSLA L + F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMES G L+IHMS + +VL F F + RG V MK K WL ++ +I+
Sbjct: 106 RPDAFLGPGCVYSVASVGRFASHWKLPLITAGGLAYGFDN--SEEFRTLVRTGP--TTTKLGDFVNSLHAEFNWTRRALLIFHDLKRDDRPHFFLSEGIYINLLAENMTVEVLPYEDNTSYQEIVTFIRES---------GRIVYICGPLQTFFNIMSTFEEEVKNTEDYAIFYLDAFGESLSNEAHQPWH----TSAMQWKDPIKLFQNVFVITFREPDNPEYAAFRTELHKRATQDFNVQLEPSLMDYIAGCFYDGFVLYATALNEALADGVSQNDGINITTRMLNRSIWGVTGLVSTDQNNARYTDFSLWSMSNLTTGQYVAGHYNGTNKEIVWSKKG--IQWAKGIPIDDPRCLV------SCEGR------------SWVLLFFKGLSYIGNRKLKLEKELARMLWRIKWEDLQFESPNKYHKRA-------------GSRLTLSQRG---------------SSYGSLISAHGKH-------------------------QLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFVGACIDPPNICIVTEYCPRGSLQ---------VNTYASCTLL-----GMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSYD---NEDSHELYARKLWTAPELLIYDRPPP-QGTQKGDIYSFGIILQEIALRNGPFYVEAMDLSPKEIIQKVRNGQRPYFRPTTDNSRHCEE-LTILMEGCWAEDPTERPDFSHIKIFITKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRRAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTS--------NVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFDLQLRGDVEMKVK------WLFLKEELIL 1003
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 737.258 bits (1902), Expect = 0.000e+0 Identity = 404/882 (45.80%), Postives = 556/882 (63.04%), Query Frame = 2
Query: 737 AVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLT---SKTN---NQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETR--EKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSL-QDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICS-EGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+VV C R+ +++AH G+YVF +D + S++N ++KPW ++ DE +AKEAY++++ ++ + P++ EY++F+ ++K R E++ ++E++ N G F+D++++Y ALN T++ +G IT+ MWNRT +G+TGE +ID NGDR D+S+ D+ D +TG F +V +Y G I V G I W P P+CG+ + C + + +I + ILL ++ F IY+++K + EL +M W + W+N++ EK R + S RG S G ++ + Q N KT Y+GN+VA+K ++ KK+E+ R +L E+K ++++ NEH+ RF+G C+D P ++TEYCP+GSL QDILENE I LDW+F++SL+ DI +GM++LH S IG HG+LKSSNC+VDSRFVLKI D+GL R E D ++ Y LWTAPE+LR Q + K DVYS GII QE+ RNG FY+ ++L PK+IV+ V Q +RP S +E C E L ++++ W ED + RPDF IK ++ NK +S NILDNLLSRMEQYANNLEELV +RT+ YLEEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG ++ +EIARMSLA L A+ F+I H+ +++LRIGIH+GPVCAGVVGLKMPR+CLFGDTVNTASRMESNG LKIH+S+ + +VL F F + RG V MKGKG TYWL GE
Sbjct: 5 SVVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPWKRGDEFDE---QAKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPGGS--IPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARRSA-------------GSKLTLSMRG---------------SSCGSLLTT---------------------QGRNQMFAKT----GYYRGNLVAIKPIN-KKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSEC---EDMHSLYAKKLWTAPELLR-LEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVEGMDLSPKEIVQKVKNGQRPYFRP--STDESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNK-ENSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGE 820
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 555.829 bits (1431), Expect = 0.000e+0 Identity = 283/511 (55.38%), Postives = 368/511 (72.02%), Query Frame = 2
Query: 1832 KGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPY-RPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGD------SGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGED 3340
+GN+V + ++ KK+E+ R +L E+K ++++ NEH+ RF+G C+D P ++TEYCP+GSLQDILENE I+LDWMF++SL+ DI +GM+YLHS+ IG HGNLKSSNC+VDSRFVLKI D+GL +R + + Y+ LWTAPE+LR E+ + + K DVYSF II QE+ R+G FYL +L K+IV+ V K+ PY RP + SE L ++++ W E+ + RPDF IK +++ + D + ILDNLLSRMEQYANNLEELV +RT+ YLEEK K E LLY +LP SVA QL R ETV AE+++ V+IY SDIVGFTA+SA+STPMQV+ LN LYT FD+II++FDVYKVETIGDAYMV SGLP NG H E+ARM+LA LSA+ F I H+P +R+ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRME+ G +IH+S + +L + F++ G V++KGKG TYWL GE+
Sbjct: 1 QGNLVEIPFIN-RKKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSK---ADSSANYFEKRLWTAPELLR-LEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEANHLTAKEIVQRV-KLGEWPYLRPTVDPGG-HSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 466.077 bits (1198), Expect = 4.076e-150 Identity = 252/512 (49.22%), Postives = 342/512 (66.80%), Query Frame = 2
Query: 1814 ITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLR-GTKEYLLE-NDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTK-VQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
I +Y+GN VALK L + ++ N K++ + +E++ F GVC++ P ++T+YC KGSL+D+L+ LDWMFK S DI GMI+LH S I HGNLK S CL+DSR +K+ FG+ + R G K L+ N+ +++ L WTAPE+LR ++ + + K DV+SF I+ +EV+Y I+LEPK I++ V + + P RP L+E C + +IRQ W E RPDF ++ M+R + GD NILDN++S++E+YAN+LEE+V+ RT Q EK+KT+ LL S+LP V QL +TV E YE+V+I+F DIVGFTA+SA STP++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP RNG H+ EIA MSL FLS+I F+I H P ++++LRIGI+SGPV AGVVG MPRYCLFGDTVN ASRMES G PL IH+SE + ++L+ + + +RG +N+KGKG Q TYWL G+
Sbjct: 212 IPIGIYQGNQVALKFLERTHPPDLKSNRF--ALKMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLR-MEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYVGIHLEPKDIIDQVRDGIAVPPLRPLLTER--CEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDM-NILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717 HSP 2 Score: 63.5438 bits (153), Expect = 2.204e-10 Identity = 45/175 (25.71%), Postives = 82/175 (46.86%), Query Frame = 2
Query: 1058 FHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRT---IQGITGEMSIDENGDRNADYSVLDMDKD---TGIFKIVAN-YIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALIN--GFYIYKRVK---FQAELNAMNWLIPWDNV 1546
HD+ +LYA+A+ + + +G + R + G +G++SID NG+R DY+V D+ K TG +I + Y + + E Q + W + + PP P CG+ + C I ++L+ + +IL +I F Y V+ Q ++ W I ++++
Sbjct: 4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKMGWPDGR--PPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTVAFLTYLVVQSRSLQESMDTTWWKINFEDI 176
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008986.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008986.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 438.343 bits (1126), Expect = 1.014e-140 Identity = 241/501 (48.10%), Postives = 328/501 (65.47%), Query Frame = 2
Query: 1859 LHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLR-GTKEYLL----ENDEYAYY-RNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTK-VQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
+HG+ +VEI I + +++ + +E++ F GVC++ P ++T+YC KGSL+D+L+ LDWMFK S DI GMI+LH S I HGNLK S CL+DSR +K+ FG+ + R G K L + D +A + L WTAPE+LR ++ + + K DV+SF I+ +E R + I++ V + + P RP L+E C + +IRQ W E RPDF ++ M+R + G NILDN++S++E+YAN+LEE+V+ RT Q EK+KT+ LL S+LP V QL +TV E YE+V+I+F DIVGFTA+SA STP++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP RNG H+ EIA MSL FLS+I F+I H P ++++LRIGI+SGPV AGVVG MPRYCLFGDTVN ASRMES G PL IH+SE + ++L+ + + +RG +N+KGKG Q TYWL G+
Sbjct: 135 VHGTDRVEIP----IGIYQMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLR-MEDLPVNGTPKGDVFSFAILMRESTPREWPTATRANRVPFPDIIDQVRDGIAVPPLRPLLTER--CEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 628
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 441.425 bits (1134), Expect = 9.789e-137 Identity = 237/514 (46.11%), Postives = 340/514 (66.15%), Query Frame = 2
Query: 1805 KTFITTALYKGNVVALKQLHGSKKVEI-NRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIP-YRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
K F +Y+GN VALK L ++ ++ ++ LL E++ ++ L +E++ F GVC++ P ++T+YC KGSL+D+L+ LD MFK S DI GMI+LH S I HGNLK S CL+DSR +K+ FG+ + R K+ + + L WT+PE+LR + + K DV+SFG++ +E++Y +++EPK+I++ V + + P RP L+E C + +I++ W E RPDF +I M+R + G +ILDN++S++E+YAN+LEE+V RT Q EK+KT+ LL S+LP V QL +TV E +E V+I+F DIVGFTA+SA S+P++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP RNG H+ EI+ MSL FLS+I F+I H P +++++RIG++SG V AGVVG MPRYCLFGDTVN ASRMES G PL+IH+SE + +L++ + + +RG + +KGKG Q TYWL+G+
Sbjct: 543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKKGKIMDVNNQDIAELFWTSPELLRMEI-FPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGVDMEPKEIIDQVREGKCSPPLRPLLTER--CEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHR-SILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGK 1052 HSP 2 Score: 83.1889 bits (204), Expect = 2.333e-16 Identity = 72/361 (19.94%), Postives = 156/361 (43.21%), Query Frame = 2
Query: 374 FGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDS---ENYKNKTFKSVV-------LLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRT-----NEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRT---IQGITGEMSIDENGDRNADYSVLDMDK---DTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNC 1393
GP+C + L W++P++ G + R Y T R+ S + + + + + W+R ++ + ++ L+ S E ++ T + + +L+ + LL D+ ++ +V+L E R +LL+A L G+++F+ + + ++ + ++ + +A ++ T + S +Y F++EV+ R S +E + + HD+ +LYA+A+ + + +G I R + T G++G+++ID NG+R DY+V ++ K + ++ + + E Q + W + PP P+CG+ + C
Sbjct: 90 LGPVCAEASEVTGLLAAQWNVPMLGFVGHTQ--RMDSSAVYDTYVRIMSPL--QRMGQMLEATMRHFGWTRAAMLGGTAQNSTWANIDELWASVERELARSVTITARIKYDTSDKVLHRQNLL--DISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQF------EDSFWKSVAAERLDTQTLQALEPVMLFTIKAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPYAAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQKKGNSSQFLPVMVFDTFQGSISFTPEYQKMVW--PEGGPPNDMPICGFLGELC 436
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 73.1738 bits (178), Expect = 1.821e-13 Identity = 51/194 (26.29%), Postives = 96/194 (49.48%), Query Frame = 2
Query: 1829 YKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFY-LSDINL 2407
+ VVA+K++ E+N +++ E+ +KNLN+ +I ++ G + + ++L EYC GSL+ ++ L + + G+ YLH H ++K++N L+ + +K+ DFG+ + + L L W APEIL ST +D++S G E++ +N ++ L+D N+
Sbjct: 46 HTDQVVAIKEVVYENDEELN-DIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAG-------TLNWMAPEILGNR-----GASTLSDIWSLGATVVEMLTKNPPYHNLTDANI 226
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 72.7886 bits (177), Expect = 2.050e-13 Identity = 53/192 (27.60%), Postives = 92/192 (47.92%), Query Frame = 2
Query: 1835 GNVVALKQLHGS--KKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDIN 2404
G + A K + + K + + LL E++ K++++ +I +FI D ++L E CP GSL ++L+ ++ + +F Q IC + Y+HS H +LK N DS + LKI DFGL + + +Y + APE+L H S + D++S G++ ++ F D+N
Sbjct: 104 GEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANE----SERKYTICGTPNYIAPEVLMGK---HSGHSFEVDIWSLGVMLYALLIGKPPFQARDVN 287
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 66.2402 bits (160), Expect = 2.684e-11 Identity = 45/162 (27.78%), Postives = 81/162 (50.00%), Query Frame = 2
Query: 1871 KKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQD-ILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGII 2353
K++ ++ + E + L + HICR +C + ++L EY G L D I+++ I KF+ + I +IYLH+N H +LK N ++ +KI DFGL + +++ L + + +L + APE+L+ + DV+SFG++
Sbjct: 183 KEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQL-----HTFCGSLYFAAPELLKANPYT----GPEVDVWSFGVV 333
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 65.4698 bits (158), Expect = 3.936e-11 Identity = 53/189 (28.04%), Postives = 98/189 (51.85%), Query Frame = 2
Query: 1835 GNVVALKQLHGSKKVEINRNLLI-EVKKVKNLNNEHICRFIGVCLDAPQH-WLLTEYCPKGSLQDILENEQINLDWMFKFS------LLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGL-EKL--RGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVV 2368
G+ VA+KQ+ SK+ + L++ E+ +K+ +++I F+ L W++ E+ GSL DI+EN N + + ++++ C+G+ +LH H ++KS N L+D+R +KI DFG +L + +K + Y W APE++++ + K DV+S GI+ E++
Sbjct: 588 GDKVAIKQMVLSKQPR--KELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPY-------WMAPEVVKQR-----EYDEKIDVWSLGIMTIEML 762
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 63.929 bits (154), Expect = 1.175e-10 Identity = 43/158 (27.22%), Postives = 80/158 (50.63%), Query Frame = 2
Query: 1904 EVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICR----GMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEV 2365
E+ +K L++E+I + G + + EY P GS+ +L N F+ SL+ + R G+ YLH H ++K +N L+D + +KI DFG+ K + + +N + ++ W +PE++++T + KAD++S G + E+
Sbjct: 504 EMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISK-KLSPLNKKQNKRASLQGSVFWMSPEVVKQTA-----TTAKADIWSTGCVVIEM 650
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9]) HSP 1 Score: 525.013 bits (1351), Expect = 2.720e-175 Identity = 275/521 (52.78%), Postives = 360/521 (69.10%), Query Frame = 2
Query: 1790 NLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSN-IGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEI---CSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGED 3340
N++ + F T +YK N+VA+K+++ +++E+ R + E+K ++ + +E++ F G C++ P +L +YCPKGSLQDILENE I LD MF SLL DI +GM YLHS I HG LKS NC+VD R+VLKI D+GL K + ++ E EYA Y LWTAPE+LR + + + K DVYSFGII QE++ R+G F LS EP I+E VT+V+ P+RP LS + G+ + + W+E+ RPDF I+ +R L G S NI+DN+++ +E+YANNLE LV +RT Q +EKRKTE+LL MLP SVA L+ + VTAE+++ VSI+FSDIVGFT+LS+ESTP+QV++LLN LYT FD II ++DVYKVETIGDAYMV SGLP RNG H EIA M+L L I F+I H+PN +++LRIGIHSG AGVVG KMPRYCLFGDTVNTASRMESNG LKIH+S + +L + I KRG+V +KGKG TYWL G D
Sbjct: 1 NINQRQIFTTVGIYKSNMVAIKRIN-KRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRKLWTAPELLR-AADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYYTNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLPMGKQS-NIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80]) HSP 1 Score: 504.212 bits (1297), Expect = 9.116e-167 Identity = 261/490 (53.27%), Postives = 350/490 (71.43%), Query Frame = 2
Query: 1871 KKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRG-TKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYL-NKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAI-FEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWL 3328
+ ++I+R LL+E+K+++++ ++++ +FIG C+ P ++ +YC +GSLQDILEN+ + LD +F SLL DI +GM YLH S+I HGNLKSSNCLVDSR+VLKI D+GL LR +K+ +E + +R+LLW APEILR + + + K DVYSF II QE R+G + S +EPK I+E V K + PYRP ++ +E L +++Q W ED LRPDF IK +R + +K G NI DN+++ ME YA+NLE LV QRT+Q ++EKRKT+ LL S+LP+ VA QL + + V AES+ V+IYFSDIVGFT+LSAESTPMQV+ LN LYT FD II+ +DVYKVETIGDAYMV SGLP RNG H EIA+M+L + A+ F + HKP +++LR+G H+GPV AGVVG M RYCLFGDTVNTASRMESNG PL+IH+S+Q+ DVL F++ RG+V++KGKG T+WL
Sbjct: 11 RTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIETN----WRDLLWVAPEILRIPSRPP-KGTHKGDVYSFSIILQEFHTRDGPY--SANYMEPKAIIEKVRKSEFPPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO27923 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7T7X3]) HSP 1 Score: 418.313 bits (1074), Expect = 1.284e-135 Identity = 210/430 (48.84%), Postives = 290/430 (67.44%), Query Frame = 2
Query: 2024 ILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEI--HLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSE--NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMK 3298
+L N+ I LDWMF+ S DI GM +H S I HGNLKSSNCL+DSR+ KI D+GL+ LR + + E+A YRNL WT PE+L H K+ DVYS+GI+ E++ R+ + + L K ++E V K Q +RP S+ E + ++ + W D RP F IK ++ N G + NI+DN+++ M +Y + LE++V +RT+Q EEK KT++LLY MLP+ +A +L + V+AES++ V+I+FSDIVGFT+++A+STP+QV++LLN+LYT FD +++ DVYKVETIGDAYMV SGLP RNG+ H E+A M+L LS + +FQIPH P+++V+LRIGIHSG AGVVGLKMPRYCLFGDTVN ASRMES+GL L+IH+S + +VL + + +RG V MK
Sbjct: 2 LLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRAN-QTPKDIGEFAVYRNLFWTVPELLPLADGFKDHKNKTQAGDVYSYGIVLYEIITRDEPYSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLK-ANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4]) HSP 1 Score: 419.083 bits (1076), Expect = 4.618e-135 Identity = 222/492 (45.12%), Postives = 317/492 (64.43%), Query Frame = 2
Query: 1907 VKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEI--HLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSE--NEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPE 3367
+K V++L++ ++ R++GVC+++P +++ +C +G+LQD+L N+ I LDWMF+ S DI GM +H S I HGNLKSSNCL+DSR+ KI D+GL+ LR + + E+A Y+NL WTAPE+L K+ DVYS+GI+ E++ R+ + + L K ++E V K Q +RP S+ E + ++ + W D RP F IK + L G + + SR Y NN +LV R + KR LL +L + +A +L + +V+AES++ V+I+FSDIVGFT+++A+STP+QV++LLN+LYT FD +++ DVYKVETIGDAYMV SGLP RNG+ H E+A M+L LS + +FQIPH P+++V+LRIGIHSG AGVVGLKMPRYCLFGDTVN ASRMES+GL L+IH+S + +VL + + +RG V MKGKG TY+L G+D P+P+
Sbjct: 1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRAN-QTPKDIGEFAVYKNLFWTAPELLPLADGFKDRKNKTQAGDVYSYGIVLYEIITRDEPYSTNTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIK---KKLKANGMGNGKISGMFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKDG-FDKPLPD 478
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1]) HSP 1 Score: 417.927 bits (1073), Expect = 3.072e-134 Identity = 223/467 (47.75%), Postives = 307/467 (65.74%), Query Frame = 2
Query: 1811 FITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTK-ADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGL 3205
F + K +VALK L + + R++LIE+K+V+++ + ++ +IGVC P ++++YC +GSLQ+IL N++I+LDW F+ S DI GM +H S+I HG+L+SS CL+DSR+V K+ DFGL L+ + E +A Y L W APE+L+ + T+ DVYSFGII E++ R + ++ P +++E + P+RP + EI + + +++ Q W +D RP F IK +R L KGG S +I+DN+L ME Y LE +V++RT Q +EK KT++LLY MLP+ +A L R E V AESY V+I+FSDIVGFT L+A STP+QV++LLN LYT FD+II+ DVYKVETIGDAYMV SGLP RNG H EIA M+L LS++ F+ H PN+ + LRIGIH+G AGVVGLKMPRYCLFGDTVN ASRMES G+
Sbjct: 59 FCEHSFIKSYLVALKMLR-KDSLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQYSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTE--FAPIEVIERIRCHLNPPFRP-ETPFEIRNRSVTKLMTQCWNDDPQARPTFSDIKRQLRLL-KGGKS-SIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 717.613 bits (1851), Expect = 0.000e+0 Identity = 425/1034 (41.10%), Postives = 605/1034 (58.51%), Query Frame = 2
Query: 293 ADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIY----EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLE-IDMGSENAVVVLCVEPESVRRILLKAHKLNFINGE-YVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKST-KADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
A C SR + V + S+P V+FGP C Y LA + R + W +P+IT G + F ++ +EY T+ R+ T L + +NW SR +I+ + ++ S G + ++ N T + N + E + EN ++ P ++K + + E Y +D+ ++KPW + D N + ++S+ +T P++ EY++F +++ R +G ++E S + G F+D +LYA+AL++T+A NG ITR+ NR+ G+TG +SID+ RN D + M +++TG + +V+ Y G + + + + I W + PP P C ++ + C + G +++ + A+++F I+ F IY+++K + EL M W + W+++ E+ K H+ R S+RG S G ++ ++ + F T +KGN+VA+K ++ K++E+ R +L+E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILENE INLDWMF++SL+ DI +GM +LH S G HGNLKSSNC+VDSRFVLKI D+GL R + E +D +A Y LWTAPE+L + H + T K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP +++ SE L ++ W ED + RPDF IK M LNK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIA MSLA L + F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + +VL F F + RG V MKGKG TYWL GE +
Sbjct: 89 APGSCAESRAQVV-VVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGFEKL--DEYKTIVRIGP--STTKLGAFVNVLHTQFNWTSRAVVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQDPESYAIFYLDVFAESLTHRKPWQNAK-FDWTN--PIQVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCG--PPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRA-------------GSRLTLSQRG---------------SSYGSLITAQGK-------------------------YQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NDDSHALYAKKLWTAPELL--IYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMDLSPKEIVQKVRNGQRPYFRP-TTDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKT 1050
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 698.353 bits (1801), Expect = 0.000e+0 Identity = 419/1036 (40.44%), Postives = 590/1036 (56.95%), Query Frame = 2
Query: 293 ADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLT---------VTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNV--ETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKST-KADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
A C SR + V + S+P V+FGP C Y LA + R + W +P+IT G + F ++ +EY T+ R+ T L + +NW+ R+V +D L + + ++ E +F+N+ + T + +P+ ++ D E+ KE RS T +T P++ EY++F +++ R +G ++E S + G F+D +LYA+AL++T+A NG ITR+ NR+ G+TG +SID+ RN D + M +++TG + +V+ Y G + + + + I W + PP P C ++ + C + G +++ + A+++F I+ F IY+++K + EL M W + W+++ E+ K H+ R S+RG S G ++ ++ + F T +KGN+VA+K ++ K++E+ R +L+E+K ++++ H+ RFIG C+D P ++TEYCP+GSLQDILENE INLDWMF++SL+ DI +GM +LH S G HGNLKSSNC+VDSRFVLKI D+GL R + E +D +A Y LWTAPE+L + H + T K DVYSFGII QE+ RNG FY+ ++L PK+IV+ V Q +RP +++ SE L ++ W ED + RPDF IK M LNK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRK E+LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFT++SAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H REIA MSLA L + F+I H+PN ++ LRIGIH+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG LKIH+S + +VL F F + RG V MKGKG TYWL GE +
Sbjct: 89 APGSCAESRAQVV-VVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGFEKL--DEYKTIVRIGP--STTKLGAFVNVLHTQFNWTS-------------RAVVIFYD--------------------------------------------LKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCG--PPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRA-------------GSRLTLSQRG---------------SSYGSLITAQGK-------------------------YQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NDDSHALYAKKLWTAPELL--IYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMDLSPKEIVQKVRNGQRPYFRP-TTDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKT 998
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 600.127 bits (1546), Expect = 0.000e+0 Identity = 300/515 (58.25%), Postives = 389/515 (75.53%), Query Frame = 2
Query: 1802 IKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
++ + T YKGN+VA+K ++ K++E+ RN+L E+K +++++NEH+ RFIG C+D P ++TEYCP+GSLQD++E+E + LDWMF++SL+ DI +GM +LH S I HGNLKSSNC+VDSRFVLKI D+GL+ LR + +D +AYY LWTAPE+LR T + L + K DVYSFGII QE+ GVFY+ L PK+I++ V + + RP L + SE L ++++ W E+ RPDF TIK ++R ++G S NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H RE+ARM+LA L A+ F+I H+P++++ LRIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES G LKIH+SE + VL+ F F + RG++ +KGKG+ TYWL GED+
Sbjct: 545 LQIYTKTGYYKGNLVAIKYIN-KKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLR-TEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHTLIPKEIIQGVIRGGVPLLRPSLCFHS-HSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 1052 HSP 2 Score: 148.673 bits (374), Expect = 8.094e-36 Identity = 111/436 (25.46%), Postives = 203/436 (46.56%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSR-VKLIY--------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMN------LTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
C S PL V L + P + GP CDYS +P+AR WD+P++T + F + ++ +T N+ L KI + + W LI+ E+T + +L N + +N + L++I + VV LC +++R ++++ K YVF IDL +KP D+ + A+ A+RS+ +T P++ EY F++ +K + + ++++S N G F+D ++LY+ ALN+T++ + G +T++MWNRT QG+ G + +D+ GDR D+++ DM D ++G F++V Y + + +G W PP P CG+ N C + + + + + + + +IY+++K + EL A W + W +++
Sbjct: 87 CSDSAAPLV-AVDLKLSHDPWAFIGPGCDYSSSPVARFTTHWDVPMVTAGARADGFSK-----FAAVT--NTGPTHKKLGEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQI-IQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPGGS--PPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQ 511
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 598.971 bits (1543), Expect = 0.000e+0 Identity = 300/515 (58.25%), Postives = 389/515 (75.53%), Query Frame = 2
Query: 1802 IKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDS 3343
++ + T YKGN+VA+K ++ K++E+ RN+L E+K +++++NEH+ RFIG C+D P ++TEYCP+GSLQD++E+E + LDWMF++SL+ DI +GM +LH S I HGNLKSSNC+VDSRFVLKI D+GL+ LR + +D +AYY LWTAPE+LR T + L + K DVYSFGII QE+ GVFY+ L PK+I++ V + + RP L + SE L ++++ W E+ RPDF TIK ++R ++G S NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R ETV AE+++ V+IYFSDIVGFTALSAESTP+QV+ LLN LYT FD+II++FDVYKVETIGDAYMV SGLP RNG +H RE+ARM+LA L A+ F+I H+P++++ LRIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES G LKIH+SE + VL+ F F + RG++ +KGKG+ TYWL GED+
Sbjct: 486 LQIYTKTGYYKGNLVAIKYIN-KKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLR-TEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHTLIPKEIIQGVIRGGVPLLRPSLCFHS-HSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 993 HSP 2 Score: 77.0258 bits (188), Expect = 8.127e-14 Identity = 93/427 (21.78%), Postives = 168/427 (39.34%), Query Frame = 2
Query: 305 CLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNW-SRVKLIY--------EQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
C S PL V L + P + GP CDYS +P+AR WD+P++T GA R +++ +T N+ L KI + + W LI+ E+T + +L N + +N + L++I + VV LC +++R ++++ K YVF IDL +KP D+ + A+ A+R V + F +S +Y L+ T ++ + +W G+ G + +D+ GDR D+++ DM D ++G F++ ++P +G W PP P CG+ N C + + + + + + + +IY+++K + EL A W + W +++
Sbjct: 87 CSDSAAPLV-AVDLKLSHDPWAFIGPGCDYSSSPVARFTTHWDVPMVT-AGA----RADGFSKFAAVT--NTGPTHKKLGEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQI-IQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGDQDDHAARLAFR--------------------------------VRHPSIF-----NSFSVYNLS---TTITPQSFMQIKMCSEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVK---------HLP-KGLNFQWPGGS--PPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQ 452
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799]) HSP 1 Score: 586.26 bits (1510), Expect = 0.000e+0 Identity = 298/513 (58.09%), Postives = 376/513 (73.29%), Query Frame = 2
Query: 1802 IKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLH-SNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGE 3337
++ F T YKGN+VA+K + K++E+NR +L E+K ++++ NEH+ RFIG C+D P ++TEYCP+GSLQDILEN+ I L+WMFKFSL+ DI +GM++LH S I HG LKSSNC+VD+RFVLKI D+GL R +E + +D ++YY LW APE+LR Q + K DVYSF II QEV R G FYL L PK+IV+ V RP + E L +++++ W E+ + RPDF I+ ++R NK + NILDNLLSRMEQYANNLEELV +RT+ Y EEKRK E LLY +LP SVA QL R ETV AE+++ VSIYFSDIVGFTALSAESTPM+V+ LLN LYT FD++I++FDVYKVETIGDAYMV SGLP RNG +H REIARM+LA L + F+I H+P ++++LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNT+SRMES+G LKIH+S + DVL F F + RG +++KGKG TTYWL GE
Sbjct: 553 LQVFAKTGYYKGNIVAIKYTN-KKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFR--QESDVGSDSHSYYAQKLWMAPELLRMENPPP-QGTQKGDVYSFSIILQEVALRRGAFYLDGDPLSPKEIVDRVILGDWPCLRPSIDPQSHSPE-LGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGE 1059 HSP 2 Score: 177.948 bits (450), Expect = 6.051e-45 Identity = 124/441 (28.12%), Postives = 217/441 (49.21%), Query Frame = 2
Query: 275 LKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSR-VKLIYEQTFLN--FCR-SVGTLFDSENYKNKTFKSVVL------LNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYG-SVEES--NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDM-DKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKN--CPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVE 1549
K +++ C S PL V L KP + GP C Y+ +P+ WD+P+IT GA I Y T+T N+ L +I + + W V L++ + C ++ L++ N + + V +N +L D+ + V+ +C P+ RR++++ K + + +YVF+ IDL +N++PW + D + AK+A++S+ ++ + P+++EY+ F++++K + SV++S N G F+D L+LYA ALN+T + G I+ KMWNRT G+TG + +D +GDR D+++ D+ D ++ F+IV Y ++ PV G + W+ P P CG+ N C + I + IT+ I L +I +++K + EL A W I WD+++
Sbjct: 92 FKSSENSNGICSESVAPLV-AVDLEFAYKPWAFIGPGCSYTASPVGLFTTHWDVPLIT-AGAPAI--AFLDGIYPTIT--NTGPTHKKLGRFALRICEHFGWREYVTLMFSDNKEDDRPCYFAMEGLYEELKSINISLQDSVFEENKPPINYSQILA-DIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPWARGDQDDTI---AKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRWLGGAR--PLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQ 520
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1) HSP 1 Score: 2133.61 bits (5527), Expect = 0.000e+0 Identity = 1038/1041 (99.71%), Postives = 1039/1041 (99.81%), Query Frame = 2
Query: 263 FYSKLKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK 3385
F KLKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEY+NFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK
Sbjct: 77 FIRKLKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK 1117 HSP 2 Score: 166.392 bits (420), Expect = 2.015e-41 Identity = 79/79 (100.00%), Postives = 79/79 (100.00%), Query Frame = 3
Query: 36 MKSKDLSHLFILFYSFAVFIIICKSDITDNFPNANPDYPLAIIMIPDDIRHNFNKNLMLSAFDIALEKIRTWNIHPFIR 272
MKSKDLSHLFILFYSFAVFIIICKSDITDNFPNANPDYPLAIIMIPDDIRHNFNKNLMLSAFDIALEKIRTWNIHPFIR
Sbjct: 1 MKSKDLSHLFILFYSFAVFIIICKSDITDNFPNANPDYPLAIIMIPDDIRHNFNKNLMLSAFDIALEKIRTWNIHPFIR 79
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1) HSP 1 Score: 2070.82 bits (5364), Expect = 0.000e+0 Identity = 1005/1006 (99.90%), Postives = 1006/1006 (100.00%), Query Frame = 2
Query: 368 VWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK 3385
VWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEY+NFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK
Sbjct: 53 VWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGTLFDSENYKNKTFKSVVLLNAETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCEFSK 1058
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1) HSP 1 Score: 1103.2 bits (2852), Expect = 0.000e+0 Identity = 562/1064 (52.82%), Postives = 738/1064 (69.36%), Query Frame = 2
Query: 296 DSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLI-----YEQTFLNFCRSVGTLF---DSENYKNKTFKSVVLLNA---------ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRF-------QYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPS-------------RVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLS-DINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 3364
DSDCL + PLY +V +K P V FGPICDY +APIARL+ FW+ P+IT F + E+ TLTRV S + + L ++F Y W++ K I Y T +C +G + KN K L+ + +L +G++NA+ +LC +P+ VR+I+L+A LNFINGEY+F+NID+ +S+ ++PWY K+ +E N AK+A+R+L+T+T ++PE E+Y+ F EVK R +Y +E+ N F+ FHD+++LYAL LNDT++ E+G + + MWNR+ + + ++I +GDR AD+S++D+++ TG+F++V+NYIG+K+ Y PV +IIDW N P P CGY+ CP G IS M A + A+I G +I++R KFQAELNAMNW+IPWD++ET EKR R K SD KRF + L K DE I N L D+ S+ + + NIS S ++ G+ D++H ++ F TAL+KGN+VALK ++ + K+EI LLIE+KK+K+++N+HICRFIGVCLD P +++ EYCPKGSL+D+L EQI LDWMFK+SL+QDICRGMIYLH+N GPHGNLKSSNCLVDSRFVLKI DFGL L+G K ++ + YY++ LWTAPE+L + + + K DVYSF +ICQE+VYRNGVF L+ D NL K+I E V P+RP L + C++ + ++I+Q+W ED + RPDF TIK +MR LNKGGD+GNILDNLLSRMEQYANNLE LV +RTEQYLEEK+K EDLLYSMLPK VA QLI+N+ V AESY+MV+I+FSDIVGFTALSAESTPMQ+IELLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARMS+AFL AI F IPH+P+K++ELRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIH+S+ + ++L TF FIIS+RG +++KGKG Q TYWLHGEDS IVDP+P
Sbjct: 96 DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRR---KFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNP-PVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 1153
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 1073.92 bits (2776), Expect = 0.000e+0 Identity = 556/1062 (52.35%), Postives = 727/1062 (68.46%), Query Frame = 2
Query: 275 LKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLN-----FCRSVGTLFDSE-----------NYKNKTFKSVVLLNAETLLEID-MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCP--NRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK-RHRLTHKV----SDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVKS--RPSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYL-SDINLEPKQIVEFV-TKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPE 3367
LK DS C+ + LY V+ + P V FGPIC Y LAPIARLL FW+IPI++ FR+ + E+ TLTR+ S + L + +K F+ Y W+ IY +T +C ++G E YK T ++ A ID +G++ AV VLCV+P SV RILLKA +LNF NGEYVFINI L +S + PWY N +AK AYRSLL+VT + PE+E++RNF +VK + +Y E N F+ F+D +LLYA ALN T+A NG+ I + MWN T +GI G ++ID +GDR AD+S+LDMD TG FK VA++IG K ++ V +DW + N+ P + P CGY+ CP ++ + G IS M + L + G+++Y+ +K QAELNAMNW+IPW+++ET EK R+ + H S + NS++ K Q + + +V + ++ + K+ P + IS S E+ G+ D + + F TALYKGNVVALK + ++++INR LLI+VKKVK+LNN+HICRFIG CL+ +++ +YCPKGSL+D+L EQI LDW+FK+SL+QDICRGM+YLH+N+GP G LKSSNCLVDSRFVLKI DFGL LRG+K+YLLE D Y++NLLWTAPE+LR + L + K DVYSF I+CQE+VYR GVF L S+ + ++IVE V + P+RP L+ C+E +I+QSW ED LRPDF TIK MR NK GDSGNILDNLLSRMEQYANNLE++V +RTEQYLEEK+K EDLLYSMLPKSVA QLI+N+ V AESY++V+I+FSDIVGFTALSAESTPMQ+I+LLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARM++AFLSAIF F IPH+P+K ++LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIH+S+ ++ +L+TF F++++RG + +KGKG TYWLHGE+ +IVDP+P+
Sbjct: 77 LKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKV--KVHQSRSQNMENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNP-PLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPK 1135
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 1072.77 bits (2773), Expect = 0.000e+0 Identity = 559/1069 (52.29%), Postives = 727/1069 (68.01%), Query Frame = 2
Query: 275 LKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLN-----FCRSVGTLFDSE-----------NYKNKTFKSVVLLNAETLLEID-MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYRNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCP--NRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK-RHRLTHKV----SDTLPNSELFTKRFQYSKRGLAKFDEESDVL-----IGNPSLAGDVVKSR----PSRVXXXXXXXXXWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYL-SDINLEPKQIVEFV-TKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPE 3367
LK DS C+ + LY V+ + P V FGPIC Y LAPIARLL FW+IPI++ FR+ + E+ TLTR+ S + L + +K F+ Y W+ IY +T +C ++G E YK T ++ A ID +G++ AV VLCV+P SV RILLKA +LNF NGEYVFINI L +S + PWY N +AK AYRSLL+VT + PE+E++RNF +VK + +Y E N F+ F+D +LLYA ALN T+A NG+ I + MWN T +GI G ++ID +GDR AD+S+LDMD TG FK VA++IG K ++ V +DW + N+ P + P CGY+ CP ++ + G IS M + L + G+++Y+ +K QAELNAMNW+IPW+++ET EK R+ + H S + NS++ K Q + + E + L + PS S+ P + IS S E+ G+ D + + F TALYKGNVVALK + ++++INR LLI+VKKVK+LNN+HICRFIG CL+ +++ +YCPKGSL+D+L EQI LDW+FK+SL+QDICRGM+YLH+N+GP G LKSSNCLVDSRFVLKI DFGL LRG+K+YLLE D Y++NLLWTAPE+LR + L + K DVYSF I+CQE+VYR GVF L S+ + ++IVE V + P+RP L+ C+E +I+QSW ED LRPDF TIK MR NK GDSGNILDNLLSRMEQYANNLE++V +RTEQYLEEK+K EDLLYSMLPKSVA QLI+N+ V AESY++V+I+FSDIVGFTALSAESTPMQ+I+LLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARM++AFLSAIF F IPH+P+K ++LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIH+S+ ++ +L+TF F++++RG + +KGKG TYWLHGE+ +IVDP+P+
Sbjct: 77 LKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKV--KVHQSRSQNVKGTRNEMENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNP-PLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPK 1142 The following BLAST results are available for this feature:
BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30007202 ID=SMED30007202|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3482bpback to top protein sequence of SMED30007202-orf-1 >SMED30007202-orf-1 ID=SMED30007202-orf-1|Name=SMED30007202-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1023bp MPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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