EF-hand domain-containing protein

Overview


Name	EF-hand domain-containing protein
Smed ID	SMED30007124
Length (bp)	512

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of EF-hand domain-containing protein (SMED30007124) t-SNE clustered cells

Violin plots show distribution of expression levels for EF-hand domain-containing protein (SMED30007124) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of EF-hand domain-containing protein (SMED30007124) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for EF-hand domain-containing protein (SMED30007124) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30007124

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30007124	h1SMcG0016949	dd_Smed_v4_3568_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30007124	h1SMcG0016949	dd_Smed_v4_3568_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30007124	h1SMcG0016949	dd_Smed_v4_3568_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of EF-hand domain-containing protein vs. Ensembl Human
Match: MCFD2 (multiple coagulation factor deficiency 2 [Source:HGNC Symbol;Acc:HGNC:18451])

HSP 1 Score: 56.6102 bits (135), Expect = 3.663e-10
Identity = 42/115 (36.52%), Postives = 63/115 (54.78%), Query Frame = 2

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

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Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

[Close]

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

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Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

[Close]

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

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BLAST of EF-hand domain-containing protein vs. Ensembl Celegans
Match: F55A11.1 (pep chromosome:WBcel235:V:11763140:11764382:-1 gene:WBGene00010075.1 transcript:F55A11.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F55A11.1)

HSP 1 Score: 49.6766 bits (117), Expect = 9.427e-8
Identity = 38/118 (32.20%), Postives = 58/118 (49.15%), Query Frame = 2

Query:  131 GDHAKDEKMKK--------PIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVI----EHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRKIYRNKE 445
            G+ A+DE   K        P   MT E+L+F YF+ HD D N  LDG EL  ++     E+   +H   +  A++       E ++   I +IL  D+ N DG++D  EF K  + +E
Sbjct:   52 GEQARDEHHIKEHLDGKVDPTANMTPEQLQFHYFNMHDLDKNGKLDGVELIKAITHFHAENPGPQHTQNNANANHQPPPLPSEVELETMIDSILKDDDFNADGFIDYGEFLKAQKLRE 169

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BLAST of EF-hand domain-containing protein vs. Ensembl Fly
Match: CG17271 (gene:FBgn0038829 transcript:FBtr0083993)

HSP 1 Score: 54.299 bits (129), Expect = 6.099e-9
Identity = 39/112 (34.82%), Postives = 60/112 (53.57%), Query Frame = 2

Query:  104 DIVKDKEHLGDHAKDEKMKKPIDA--MTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQ-FQEGDIRNFISNILLFDNNN-DGYLDLNEFRK 427
            +I +++ H+ +H     M+ PID   M++ EL+F YF  HD D+N  LDG EL  S+I   E   K +      +  E+ F + ++   I  IL  D+ + DGY+D  EF K
Sbjct:  143 NIQQERAHIQEH-----MQVPIDTSKMSEAELQFHYFKMHDSDNNNKLDGCELIKSLIHWHEQGSKEQPNGEKPHVEEKVFSDEELVALIDPILQMDDTSRDGYIDYPEFIK 249

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BLAST of EF-hand domain-containing protein vs. Ensembl Fly
Match: CG17271 (gene:FBgn0038829 transcript:FBtr0110823)

HSP 1 Score: 51.9878 bits (123), Expect = 3.543e-8
Identity = 39/129 (30.23%), Postives = 66/129 (51.16%), Query Frame = 2

Query:  104 DIVKDKEHLGDHAKDEKMKKPIDA--MTDEELEFFYFHEHDKDHNKLLDGNELFMSVI-------------EHMEYEHKNKSTKADNNTTEQ-FQEGDIRNFISNIL-LFDNNNDGYLDLNEFRKIYRN 439
            +I +++ H+ +H     M+ PID   M++ EL+F YF  HD D+N  LDG EL  S+I              H E   + ++ + D++ +   + +  + + I  +L   D NNDG++D  E+RK   N
Sbjct:  143 NIQQERAHIQEH-----MQVPIDTSKMSEAELQFHYFKMHDSDNNNKLDGCELIKSLIHWHVKDSGEKPAEAHQEGHAEGQAQQPDDHKSGSVYTDKALEDTIDYVLKSMDLNNDGFVDWAEYRKTEAN 266

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BLAST of EF-hand domain-containing protein vs. Ensembl Fly
Match: CG12817 (gene:FBgn0037798 transcript:FBtr0110952)

HSP 1 Score: 47.7506 bits (112), Expect = 4.758e-7
Identity = 37/120 (30.83%), Postives = 63/120 (52.50%), Query Frame = 2

Query:   83 KTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEH-MEYEHKNKSTKADNNTTEQFQEGDIRNFISNI----LLFDNNNDGYLDLNEFRK 427
            +T ++D+ +  ++  + D  KD  ++  +D +++EE  F+ F  HD D+N  LDG E+  S + H  +Y   N+      N T++ +     +FI  I    L+ D+NNDG L   EF K
Sbjct:   40 ETRRVDQHLTHEEHRIDDDLKDMGVQANLDDLSEEEKIFYMFKAHDNDNNNALDGLEMIQSAMHHNYDYFKNNERDAYLQNATDELE-----HFIEAIDKFLLIADDNNDGLLHYPEFVK 154

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BLAST of EF-hand domain-containing protein vs. Ensembl Zebrafish
Match: mcfd2 (multiple coagulation factor deficiency 2 [Source:ZFIN;Acc:ZDB-GENE-041010-8])

HSP 1 Score: 60.077 bits (144), Expect = 1.324e-11
Identity = 41/111 (36.94%), Postives = 64/111 (57.66%), Query Frame = 2

Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEF 421
            +LD ++V+D+EH+ +H +   ++K    MT +EL+  YF  HD D N LLDG EL  + I H+  E +   ++         +E D+ N I ++L  D+ NNDGY+D  EF
Sbjct:   48 RLDRNMVQDREHIMEHLEG-IVEKQESEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHREERGGDSQP-------MREEDLINLIDDVLRDDDKNNDGYIDYAEF 149

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Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEF 421
            +LD ++V+D+EH+ +H +   ++K    MT +EL+  YF  HD D N LLDG EL  + I H+  E +   ++         +E D+ N I ++L  D+ NNDGY+D  EF
Sbjct:   48 RLDRNMVQDREHIMEHLEG-IVEKQESEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHREERGGDSQP-------MREEDLINLIDDVLRDDDKNNDGYIDYAEF 149

[Close]

Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEF 421
            +LD ++V+D+EH+ +H +   ++K    MT +EL+  YF  HD D N LLDG EL  + I H+  E +   ++         +E D+ N I ++L  D+ NNDGY+D  EF
Sbjct:   48 RLDRNMVQDREHIMEHLEG-IVEKQESEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHREERGGDSQP-------MREEDLINLIDDVLRDDDKNNDGYIDYAEF 149

[Close]

Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEF 421
            +LD ++V+D+EH+ +H +   ++K    MT +EL+  YF  HD D N LLDG EL  + I H+  E +   ++         +E D+ N I ++L  D+ NNDGY+D  EF
Sbjct:   48 RLDRNMVQDREHIMEHLEG-IVEKQESEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHREERGGDSQP-------MREEDLINLIDDVLRDDDKNNDGYIDYAEF 149

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BLAST of EF-hand domain-containing protein vs. Ensembl Xenopus
Match: mcfd2 (multiple coagulation factor deficiency 2 [Source:NCBI gene;Acc:496472])

HSP 1 Score: 64.3142 bits (155), Expect = 5.133e-13
Identity = 42/113 (37.17%), Postives = 66/113 (58.41%), Query Frame = 2

Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  + +V+DK+H+ DH  D  ++KP   M+ +EL+  YF  HD D N LLDG EL  ++       H +KST+     T+  +E D+ + I ++L  D+ NNDGY+D  EF +
Sbjct:   43 RFGKSVVQDKDHIMDHL-DGVIEKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELATAI------SHVHKSTE---EPTQAMKEEDLISLIDDVLRDDDKNNDGYIDYAEFAR 145

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BLAST of EF-hand domain-containing protein vs. Ensembl Mouse
Match: Mcfd2 (multiple coagulation factor deficiency 2 [Source:MGI Symbol;Acc:MGI:2183439])

HSP 1 Score: 55.4546 bits (132), Expect = 8.751e-10
Identity = 38/115 (33.04%), Postives = 62/115 (53.91%), Query Frame = 2

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD+  V D+EH+ +H +   + +P   M+ +EL+  YF  HD D N LLDG EL +++     + HK + ++          E ++ + I  +L  D+ NNDGY+D  EF K
Sbjct:   37 SVGLDKSTVHDQEHIMEHLEG-VIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAIT----HVHKEEGSE----QAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAK 142

[Close]

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD+  V D+EH+ +H +   + +P   M+ +EL+  YF  HD D N LLDG EL +++     + HK + ++          E ++ + I  +L  D+ NNDGY+D  EF K
Sbjct:   37 SVGLDKSTVHDQEHIMEHLEG-VIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAIT----HVHKEEGSE----QAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAK 142

[Close]

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD+  V D+EH+ +H +   + +P   M+ +EL+  YF  HD D N LLDG EL +++     + HK + ++          E ++ + I  +L  D+ NNDGY+D  EF K
Sbjct:   37 SVGLDKSTVHDQEHIMEHLEG-VIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAIT----HVHKEEGSE----QAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAK 142

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BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5R8Z6|MCFD2_PONAB (Multiple coagulation factor deficiency protein 2 homolog OS=Pongo abelii OX=9601 GN=MCFD2 PE=2 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 1.759e-9
Identity = 42/115 (36.52%), Postives = 63/115 (54.78%), Query Frame = 2

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

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BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8NI22|MCFD2_HUMAN (Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 1.759e-9
Identity = 42/115 (36.52%), Postives = 63/115 (54.78%), Query Frame = 2

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD++ V D+EH+ +H +   + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   38 SMGLDKNTVHDQEHIMEHLEG-VINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLEL-STAITHV---HKEEGSE----QAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAK 143

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BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8K5B2|MCFD2_MOUSE (Multiple coagulation factor deficiency protein 2 homolog OS=Mus musculus OX=10090 GN=Mcfd2 PE=1 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 6.121e-9
Identity = 38/115 (33.04%), Postives = 62/115 (53.91%), Query Frame = 2

Query:   86 TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  LD+  V D+EH+ +H +   + +P   M+ +EL+  YF  HD D N LLDG EL +++     + HK + ++          E ++ + I  +L  D+ NNDGY+D  EF K
Sbjct:   37 SVGLDKSTVHDQEHIMEHLEG-VIDQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSIAIT----HVHKEEGSE----QAPVMSEDELVSIIDGVLRDDDKNNDGYIDYAEFAK 142

[Close]

BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8K5B3|MCFD2_RAT (Multiple coagulation factor deficiency protein 2 homolog OS=Rattus norvegicus OX=10116 GN=Mcfd2 PE=1 SV=1)

HSP 1 Score: 55.0694 bits (131), Expect = 7.767e-9
Identity = 45/151 (29.80%), Postives = 70/151 (46.36%), Query Frame = 2

Query:   14 MTSSYLLHCSIMLFVTLCFVLSDK------------TFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            M S  LL    +  +   F +               +  LD+  V D+EH+ +H +   + +P   M+ +EL+  YF  HD D N LLDG EL  + I H+   HK + ++          E ++ + I  +L  D+ NNDGY+D  EF K
Sbjct:    1 MASLQLLRGPFLCVLLWAFCVPGARAQEHGAGVHHGSVGLDKSTVHDQEHIMEHLEG-VINQPEAEMSPQELQLHYFKMHDYDGNSLLDGLEL-STAITHV---HKEEGSE----QVPPMSEDELISIIDGVLRDDDKNNDGYIDYAEFAK 142

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BLAST of EF-hand domain-containing protein vs. TrEMBL
Match: A0A0L7QMZ0 (Multiple coagulation factor deficiency protein 2 like protein OS=Habropoda laboriosa OX=597456 GN=WH47_10479 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 3.240e-12
Identity = 46/118 (38.98%), Postives = 66/118 (55.93%), Query Frame = 2

Query:  104 DIVKDKEHLGDHAKDEKMKKPIDA--MTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRKIYRNKEG 448
            +IV +K H+ +H     M+ PID   MTD+EL+F YF  HD D+N  LDG EL  S+I    +E +N      N T + F++ ++   I  IL  D+ NNDGY+D  EF +  +N   
Sbjct:  106 NIVNEKVHIAEH-----MEVPIDTSKMTDQELQFHYFKMHDADNNDKLDGCELIKSLIH--WHEQRNNEVTGPNPTEKLFKDQELVTLIDPILSMDDINNDGYIDYPEFIQAQQNAAA 216

[Close]

BLAST of EF-hand domain-containing protein vs. TrEMBL
Match: A0A0B8RZ92 (Multiple coagulation factor deficiency protein 2 OS=Boiga irregularis OX=92519 PE=4 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 1.390e-11
Identity = 47/138 (34.06%), Postives = 73/138 (52.90%), Query Frame = 2

Query:   38 CSIMLFVTLCFVLSD-------KTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            C I+L  ++  +  D          +LD+++V+DK+H+ +H  D  + KP D M+ +EL+  YF  HD D N LLDG EL  + I H+         + D    +  +E ++ N I  +L  D+ NNDGY+D  EF K
Sbjct:   16 CCIILATSIISLAEDHRDGSHHPNMRLDKNMVQDKDHIMEHL-DGVVDKPEDEMSPQELQLHYFKMHDYDGNNLLDGLEL-ATAISHVH-------RQGDGEPVQTIKEDELINLIDGVLRDDDKNNDGYIDYAEFAK 144

[Close]

BLAST of EF-hand domain-containing protein vs. TrEMBL
Match: H3AVQ5 (Multiple coagulation factor deficiency 2 OS=Latimeria chalumnae OX=7897 GN=MCFD2 PE=4 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 3.921e-11
Identity = 51/150 (34.00%), Postives = 76/150 (50.67%), Query Frame = 2

Query:   14 MTSSYLLHCSIMLFVTLCFVLSD-----------KTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            ++S  LL C +  F TL     D              +LD+++V+DK+H+ +H  D  + KP   M+ +EL+  YF  HD D N LLDG EL  + I H+  E   + +          +E D+ N I ++L  D+ NNDGY+D  EF K
Sbjct:    8 LSSICLLGCLLFPFWTLSAWAQDHFNPDIQEGHRSNIRLDKNLVQDKDHIMEHL-DGVVNKPESEMSPQELQLHYFKMHDYDGNSLLDGLEL-ATAITHVHKEEGGEHSAP-------MKEEDLINLIDDVLRDDDKNNDGYIDYAEFAK 148

[Close]

BLAST of EF-hand domain-containing protein vs. TrEMBL
Match: A0A091IY95 (Multiple coagulation factor deficiency protein 2 OS=Egretta garzetta OX=188379 GN=Z169_01307 PE=4 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 6.835e-11
Identity = 46/139 (33.09%), Postives = 73/139 (52.52%), Query Frame = 2

Query:   29 LLHCSIMLFVTLCFV------LSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDNNNDGYLDLNEFRK 427
            LL C +  F+T                +LD+++V+DK+H+ +H +   ++KP   M+ +EL+  YF  HD D N LLDG EL  + I H+  E   +  +A        +E ++ + I ++L  D NNDGY+D  EF K
Sbjct:   10 LLFCFLAAFITSALAEEHVGESQHANIRLDKNLVQDKDHIMEHLEG-VIEKPESEMSPQELQLHYFKMHDYDGNNLLDGLEL-ATAISHVHKEEGGEHIQA-------MKEEELISLIDDVLRDDKNNDGYIDYAEFAK 139

[Close]

BLAST of EF-hand domain-containing protein vs. TrEMBL
Match: A0A310SP48 (Multiple coagulation factor deficiency protein 2 like protein OS=Eufriesea mexicana OX=516756 GN=WN48_07114 PE=4 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 7.178e-11
Identity = 45/115 (39.13%), Postives = 66/115 (57.39%), Query Frame = 2

Query:  104 DIVKDKEHLGDHAKDEKMKKPIDA--MTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNIL-LFDNNNDGYLDLNEFRKIYRN 439
            +IV +K H+ +H     M+ PID   M+D+EL+F+YF  HD D+N  LDG EL  S+I    +E  N      N   + F++ ++ + I  IL L D NNDGY+D  EF +  +N
Sbjct:   97 NIVHEKAHIAEH-----MEIPIDTNKMSDQELQFYYFKMHDADNNNKLDGCELIKSLIH--WHEQGNIELTGGNTNQKLFKDDELISLIDPILHLDDTNNDGYIDYAEFVQAQQN 204

[Close]

BLAST of EF-hand domain-containing protein vs. Ensembl Cavefish
Match: mcfd2 (multiple coagulation factor deficiency 2 [Source:NCBI gene;Acc:103027418])

HSP 1 Score: 59.6918 bits (143), Expect = 2.170e-11
Identity = 40/113 (35.40%), Postives = 65/113 (57.52%), Query Frame = 2

Query:   92 KLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +LD ++V+DK+H+ +H +   ++KP   MT +EL+  YF  HD D N LLDG EL  ++       H +K  + +N  +   +E ++   I  +L  D+ NNDGY+D  EF +
Sbjct:   51 RLDRNMVQDKDHIMEHLEG-VIEKPESDMTPQELQLHYFKMHDYDGNNLLDGLELATAIT------HVHKEERGEN--SHPMKEEELIRLIDEVLRDDDRNNDGYIDYAEFAR 154

[Close]

BLAST of EF-hand domain-containing protein vs. Ensembl Medaka
Match: mcfd2 (multiple coagulation factor deficiency 2 [Source:NCBI gene;Acc:101168979])

HSP 1 Score: 60.077 bits (144), Expect = 1.514e-11
Identity = 42/119 (35.29%), Postives = 67/119 (56.30%), Query Frame = 2

Query:   74 LSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  +  +LD ++V+D++H+ +H +   + KP   MT +EL+  YF  HD D N LLDG EL  + I H+  E K + ++         +E D+   I ++L  D+ NNDGY+D  EF K
Sbjct:   45 IPSQHTRLDRNMVQDQDHIMEHLEG-VIDKPEKEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHKEEKGEHSQP-------MKEEDLIALIDDVLKDDDKNNDGYIDYAEFAK 154

[Close]

Query:   74 LSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDGYLDLNEFRK 427
            +  +  +LD ++V+D++H+ +H +   + KP   MT +EL+  YF  HD D N LLDG EL  + I H+  E K + ++         +E D+   I ++L  D+ NNDGY+D  EF K
Sbjct:   45 IPSQHTRLDRNMVQDQDHIMEHLEG-VIDKPEKEMTPQELQLHYFKMHDYDGNNLLDGLEL-ATAITHVHKEEKGEHSQP-------MKEEDLIALIDDVLKDDDKNNDGYIDYAEFAK 154

[Close]

BLAST of EF-hand domain-containing protein vs. Ensembl Medaka
Match: mcfd2 (multiple coagulation factor deficiency 2 [Source:NCBI gene;Acc:101168979])

HSP 1 Score: 49.6766 bits (117), Expect = 8.152e-8
Identity = 37/110 (33.64%), Postives = 61/110 (55.45%), Query Frame = 2

Query:   74 LSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDN-NNDG 400
            +  +  +LD ++V+D++H+ +H +   + KP   MT +EL+  YF  HD D N LLDG EL  + I H+  E K + ++         +E D+   I ++L  D+ NNDG
Sbjct:   45 IPSQHTRLDRNMVQDQDHIMEHLEG-VIDKPEKEMTPQELQLHYFKMHDYDGNNLLDGLELA-TAITHVHKEEKGEHSQP-------MKEEDLIALIDDVLKDDDKNNDG 145

[Close]

BLAST of EF-hand domain-containing protein vs. Planmine SMEST
Match: SMESG000062171.1 (SMESG000062171.1)

HSP 1 Score: 291.582 bits (745), Expect = 8.622e-103
Identity = 144/145 (99.31%), Postives = 145/145 (100.00%), Query Frame = 2

Query:   14 MTSSYLLHCSIMLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDNNNDGYLDLNEFRKIYRNKEG 448
            MTSSYLLHCSIMLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDI+NFISNILLFDNNNDGYLDLNEFRKIYRNKEG
Sbjct:    1 MTSSYLLHCSIMLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIQNFISNILLFDNNNDGYLDLNEFRKIYRNKEG 145

[Close]

BLAST of EF-hand domain-containing protein vs. Planmine SMEST
Match: SMESG000062171.1 (SMESG000062171.1)

HSP 1 Score: 266.929 bits (681), Expect = 3.179e-93
Identity = 133/134 (99.25%), Postives = 134/134 (100.00%), Query Frame = 2

Query:   47 MLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIRNFISNILLFDNNNDGYLDLNEFRKIYRNKEG 448
            MLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDI+NFISNILLFDNNNDGYLDLNEFRKIYRNKEG
Sbjct:    1 MLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKKPIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKADNNTTEQFQEGDIQNFISNILLFDNNNDGYLDLNEFRKIYRNKEG 134

The following BLAST results are available for this feature:

BLAST of EF-hand domain-containing protein vs. Ensembl Human
BLAST of EF-hand domain-containing protein vs. Ensembl Celegans
BLAST of EF-hand domain-containing protein vs. Ensembl Fly
BLAST of EF-hand domain-containing protein vs. Ensembl Zebrafish
BLAST of EF-hand domain-containing protein vs. Ensembl Xenopus
BLAST of EF-hand domain-containing protein vs. Ensembl Mouse
BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
BLAST of EF-hand domain-containing protein vs. TrEMBL
BLAST of EF-hand domain-containing protein vs. Ensembl Cavefish
BLAST of EF-hand domain-containing protein vs. Ensembl Sea Lamprey
BLAST of EF-hand domain-containing protein vs. Ensembl Yeast
BLAST of EF-hand domain-containing protein vs. Ensembl Nematostella
BLAST of EF-hand domain-containing protein vs. Ensembl Medaka
BLAST of EF-hand domain-containing protein vs. Planmine SMEST

BLAST of EF-hand domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MCFD2	3.663e-10	36.52	multiple coagulation factor deficiency 2 [Source:H...	[more]
MCFD2	3.663e-10	36.52	multiple coagulation factor deficiency 2 [Source:H...	[more]
MCFD2	3.663e-10	36.52	multiple coagulation factor deficiency 2 [Source:H...	[more]
MCFD2	3.663e-10	36.52	multiple coagulation factor deficiency 2 [Source:H...	[more]
MCFD2	3.663e-10	36.52	multiple coagulation factor deficiency 2 [Source:H...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
F55A11.1	9.427e-8	32.20	pep chromosome:WBcel235:V:11763140:11764382:-1 gen...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CG17271	6.099e-9	34.82	gene:FBgn0038829 transcript:FBtr0083993	[more]
CG17271	3.543e-8	30.23	gene:FBgn0038829 transcript:FBtr0110823	[more]
CG12817	4.758e-7	30.83	gene:FBgn0037798 transcript:FBtr0110952	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
mcfd2	1.324e-11	36.94	multiple coagulation factor deficiency 2 [Source:Z...	[more]
mcfd2	1.324e-11	36.94	multiple coagulation factor deficiency 2 [Source:Z...	[more]
mcfd2	1.324e-11	36.94	multiple coagulation factor deficiency 2 [Source:Z...	[more]
mcfd2	1.324e-11	36.94	multiple coagulation factor deficiency 2 [Source:Z...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
mcfd2	5.133e-13	37.17	multiple coagulation factor deficiency 2 [Source:N...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Mcfd2	8.751e-10	33.04	multiple coagulation factor deficiency 2 [Source:M...	[more]
Mcfd2	8.751e-10	33.04	multiple coagulation factor deficiency 2 [Source:M...	[more]
Mcfd2	8.751e-10	33.04	multiple coagulation factor deficiency 2 [Source:M...	[more]

BLAST of EF-hand domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q5R8Z6\|MCFD2_PONAB	1.759e-9	36.52	Multiple coagulation factor deficiency protein 2 h...	[more]
sp\|Q8NI22\|MCFD2_HUMAN	1.759e-9	36.52	Multiple coagulation factor deficiency protein 2 O...	[more]
sp\|Q8K5B2\|MCFD2_MOUSE	6.121e-9	33.04	Multiple coagulation factor deficiency protein 2 h...	[more]
sp\|Q8K5B3\|MCFD2_RAT	7.767e-9	29.80	Multiple coagulation factor deficiency protein 2 h...	[more]

BLAST of EF-hand domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0L7QMZ0	3.240e-12	38.98	Multiple coagulation factor deficiency protein 2 l...	[more]
A0A0B8RZ92	1.390e-11	34.06	Multiple coagulation factor deficiency protein 2 O...	[more]
H3AVQ5	3.921e-11	34.00	Multiple coagulation factor deficiency 2 OS=Latime...	[more]
A0A091IY95	6.835e-11	33.09	Multiple coagulation factor deficiency protein 2 O...	[more]
A0A310SP48	7.178e-11	39.13	Multiple coagulation factor deficiency protein 2 l...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
mcfd2	2.170e-11	35.40	multiple coagulation factor deficiency 2 [Source:N...	[more]

BLAST of EF-hand domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of EF-hand domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of EF-hand domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of EF-hand domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
mcfd2	1.514e-11	35.29	multiple coagulation factor deficiency 2 [Source:N...	[more]
mcfd2	1.514e-11	35.29	multiple coagulation factor deficiency 2 [Source:N...	[more]
mcfd2	8.152e-8	33.64	multiple coagulation factor deficiency 2 [Source:N...	[more]

BLAST of EF-hand domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000062171.1	8.622e-103	99.31	SMESG000062171.1	[more]
SMESG000062171.1	3.179e-93	99.25	SMESG000062171.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30007124 ID=SMED30007124|Name=EF-hand domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=512bp
GTTTTAATAATTTATGACTTCATCATATCTACTACATTGCTCAATAATGT
TATTTGTAACATTATGTTTTGTTCTTTCTGATAAAACATTCAAATTGGAT
GAGGATATAGTCAAAGATAAAGAACATTTAGGTGATCATGCAAAAGATGA
AAAAATGAAGAAGCCTATTGATGCAATGACTGATGAAGAATTGGAATTTT
TCTATTTTCATGAGCATGATAAAGATCATAATAAATTGTTGGATGGAAAT
GAGCTTTTTATGTCTGTAATTGAACATATGGAATATGAACATAAAAATAA
ATCTACAAAAGCTGATAATAATACAACAGAGCAGTTCCAAGAAGGCGATA
TTCGAAATTTTATTTCTAACATTTTATTATTTGATAATAATAATGATGGT
TATTTAGATTTGAATGAATTTAGAAAAATTTATCGAAATAAGGAAGGGTA
ATGAATTCTCATGTTTTAAAACTTTCAACTTATTAAATACAATTTTTTGT
CTTTGAAAAAAA

protein sequence of SMED30007124-orf-1

>SMED30007124-orf-1 ID=SMED30007124-orf-1|Name=SMED30007124-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=146bp
MTSSYLLHCSIMLFVTLCFVLSDKTFKLDEDIVKDKEHLGDHAKDEKMKK
PIDAMTDEELEFFYFHEHDKDHNKLLDGNELFMSVIEHMEYEHKNKSTKA
DNNTTEQFQEGDIRNFISNILLFDNNNDGYLDLNEFRKIYRNKEG*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR002048	EF_hand_dom
IPR011992	EF-hand-dom_pair
IPR018247	EF_Hand_1_Ca_BS

Vocabulary: **molecular function**
Term	Definition
GO:0005509	calcium ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:1.10.238.10		coord: 57..139 e-value: 1.5E-11 score: 46.3
None	No IPR available	PANTHER	PTHR23104	MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN	coord: 27..143
None	No IPR available	PANTHER	PTHR23104:SF1		coord: 27..143
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..22 score: 0.811
None	No IPR available	TMHMM	TMhelix		coord: 4..21
IPR002048	EF-hand domain	PFAM	PF13499	EF-hand_7	coord: 59..141 e-value: 1.1E-7 score: 32.2
IPR018247	EF-Hand 1, calcium-binding site	PROSITE	PS00018	EF_HAND_1	coord: 69..81
IPR018247	EF-Hand 1, calcium-binding site	PROSITE	PS00018	EF_HAND_1	coord: 124..136
IPR011992	EF-hand domain pair	SUPERFAMILY	SSF47473	EF-hand	coord: 58..141

Main menu

EF-hand domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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