Methylmalonyl-CoA epimerase

Overview
NameMethylmalonyl-CoA epimerase
Smed IDSMED30007072
Length (bp)651
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Methylmalonyl-CoA epimerase (SMED30007072) t-SNE clustered cells

Violin plots show distribution of expression levels for Methylmalonyl-CoA epimerase (SMED30007072) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Methylmalonyl-CoA epimerase (SMED30007072) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Methylmalonyl-CoA epimerase (SMED30007072) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007072

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30007072SMESG000021684.1 dd_Smed_v4_3348_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30007072SMESG000021684.1 dd_Smed_v4_3348_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30007072SMESG000021684.1 dd_Smed_v6_3348_1_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732])

HSP 1 Score: 181.415 bits (459), Expect = 1.143e-57
Identity = 86/138 (62.32%), Postives = 103/138 (74.64%), Query Frame = 3 
Query:  126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            ++   W + RLNHVAIAVPDLEKA   +++  GA+VS+  P  EHGV  VFV L N K+ELLHPLG +SPI  FL KNKAGG+HHIC+EVDNI  A+ DLK   +R+L +E KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:   38 VTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 175
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732])

HSP 1 Score: 74.3294 bits (181), Expect = 4.560e-17
Identity = 50/129 (38.76%), Postives = 57/129 (44.19%), Query Frame = 3 
Query:  153 RLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            RLNHVAIAVPDLEKA   +                                           KN L             +VDNI  A+ DLK   +R+L +E KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:    3 RLNHVAIAVPDLEKAAAFY-------------------------------------------KNILGA-----------QVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 77
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732])

HSP 1 Score: 53.5286 bits (127), Expect = 1.016e-9
Identity = 23/31 (74.19%), Postives = 27/31 (87.10%), Query Frame = 3 
Query:  300 IELLHPLGDNSPIKNFLDKNKAGGIHHICLE 392
            +ELLHPLG +SPI  FL KNKAGG+HHIC+E
Sbjct:    1 MELLHPLGRDSPIAGFLQKNKAGGMHHICIE 31
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732])

HSP 1 Score: 53.5286 bits (127), Expect = 1.016e-9
Identity = 23/31 (74.19%), Postives = 27/31 (87.10%), Query Frame = 3 
Query:  300 IELLHPLGDNSPIKNFLDKNKAGGIHHICLE 392
            +ELLHPLG +SPI  FL KNKAGG+HHIC+E
Sbjct:    1 MELLHPLGRDSPIAGFLQKNKAGGMHHICIE 31
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Celegans
Match: mce-1 (Methylmalonyl-CoA Epimerase; Mitochondrial methylmalonyl-CoA epimerase [Source:UniProtKB/TrEMBL;Acc:G5EEG4])

HSP 1 Score: 176.792 bits (447), Expect = 1.840e-56
Identity = 90/151 (59.60%), Postives = 116/151 (76.82%), Query Frame = 3 
Query:   93 AKLYLNSSFRTMSSKSWK--VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            AKL L++  RTM+S      + +LNHVAIA PDL+K+++ ++   GAKVS+  PQ EHGVYTVFVEL N+KIELLHP G+ SPI+ FL+KNK GG+HHIC+EV +I EA+  +K   +RTLG++PKIGAHG  V+FLHPKD  GVL ELE+
Sbjct:   14 AKLSLST--RTMASHPLAGLLGKLNHVAIATPDLKKSSEFYK-GLGAKVSEAVPQPEHGVYTVFVELPNSKIELLHPFGEKSPIQAFLNKNKDGGMHHICIEVRDIHEAVSAVKTKGIRTLGEKPKIGAHGKEVMFLHPKDCGGVLIELEQ 161
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368])

HSP 1 Score: 192.971 bits (489), Expect = 2.410e-62
Identity = 91/133 (68.42%), Postives = 106/133 (79.70%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ RLNHVAIAVPDLEKAT L+RD  GA+VS   P  EHGVYTVFVEL N K+ELLHPLG+ SPI  FL KNKAGG+HHIC+EVD+I  A+ DLK   +R L  EP+IGAHG PV+FLHPKD +GVL E+E+
Sbjct:   42 WKLGRLNHVAIAVPDLEKATALYRDVLGAQVSDTVPLPEHGVYTVFVELGNTKLELLHPLGEKSPIAGFLQKNKAGGMHHICIEVDDINAAIVDLKEKKIRLLSPEPRIGAHGKPVMFLHPKDCDGVLVEIEQ 174
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368])

HSP 1 Score: 193.356 bits (490), Expect = 2.597e-62
Identity = 91/133 (68.42%), Postives = 106/133 (79.70%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ RLNHVAIAVPDLEKAT L+RD  GA+VS   P  EHGVYTVFVEL N K+ELLHPLG+ SPI  FL KNKAGG+HHIC+EVD+I  A+ DLK   +R L  EP+IGAHG PV+FLHPKD +GVL E+E+
Sbjct:   59 WKLGRLNHVAIAVPDLEKATALYRDVLGAQVSDTVPLPEHGVYTVFVELGNTKLELLHPLGEKSPIAGFLQKNKAGGMHHICIEVDDINAAIVDLKEKKIRLLSPEPRIGAHGKPVMFLHPKDCDGVLVEIEQ 191
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:448311])

HSP 1 Score: 193.741 bits (491), Expect = 1.436e-62
Identity = 92/136 (67.65%), Postives = 105/136 (77.21%), Query Frame = 3 
Query:  132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            S  W + RLNHVAIAVPDLEKA  L+    GA+VSK  P  EHGVYTVFVEL N K+ELLHPLG NSPI  FL KNKAGG+HHIC+EVD+IK AM  LK   ++ L +EP+IGAHG PV+FLHPKD +GVL ELEE
Sbjct:   38 SSVWNLGRLNHVAIAVPDLEKACFLYEKVLGAQVSKTVPLPEHGVYTVFVELGNTKLELLHPLGQNSPISGFLQKNKAGGLHHICIEVDDIKAAMTSLKEKKIKILSEEPRIGAHGKPVVFLHPKDCDGVLVELEE 173
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:448311])

HSP 1 Score: 193.741 bits (491), Expect = 1.654e-62
Identity = 92/136 (67.65%), Postives = 105/136 (77.21%), Query Frame = 3 
Query:  132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            S  W + RLNHVAIAVPDLEKA  L+    GA+VSK  P  EHGVYTVFVEL N K+ELLHPLG NSPI  FL KNKAGG+HHIC+EVD+IK AM  LK   ++ L +EP+IGAHG PV+FLHPKD +GVL ELEE
Sbjct:   38 SSVWNLGRLNHVAIAVPDLEKACFLYEKVLGAQVSKTVPLPEHGVYTVFVELGNTKLELLHPLGQNSPISGFLQKNKAGGLHHICIEVDDIKAAMTSLKEKKIKILSEEPRIGAHGKPVVFLHPKDCDGVLVELEE 173
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Match: Mcee (methylmalonyl CoA epimerase [Source:MGI Symbol;Acc:MGI:1920974])

HSP 1 Score: 191.43 bits (485), Expect = 1.183e-61
Identity = 90/137 (65.69%), Postives = 105/137 (76.64%), Query Frame = 3 
Query:  129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            SS  WK+ RLNHVA+AVPDLEKA+  +RD  GA+VS+  P  EHGV  VFV L N K+ELLHPLG +SPI  FL KNKAGG+HH+C+EVDNI  A+ DLK   +R+L DE KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:   41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQVSEVVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPITGFLQKNKAGGMHHVCIEVDNISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 177
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Match: Mcee (methylmalonyl CoA epimerase [Source:MGI Symbol;Acc:MGI:1920974])

HSP 1 Score: 89.7373 bits (221), Expect = 1.013e-22
Identity = 55/137 (40.15%), Postives = 64/137 (46.72%), Query Frame = 3 
Query:  129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            SS  WK+ RLNHVA+AVPDLEKA+  +RD  GA+V                              DN                        I  A+ DLK   +R+L DE KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:   41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQV------------------------------DN------------------------ISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 123
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q9D1I5|MCEE_MOUSE (Methylmalonyl-CoA epimerase, mitochondrial OS=Mus musculus OX=10090 GN=Mcee PE=1 SV=1)

HSP 1 Score: 191.43 bits (485), Expect = 8.272e-61
Identity = 90/137 (65.69%), Postives = 105/137 (76.64%), Query Frame = 3 
Query:  129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            SS  WK+ RLNHVA+AVPDLEKA+  +RD  GA+VS+  P  EHGV  VFV L N K+ELLHPLG +SPI  FL KNKAGG+HH+C+EVDNI  A+ DLK   +R+L DE KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:   41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQVSEVVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPITGFLQKNKAGGMHHVCIEVDNISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 177
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q96PE7|MCEE_HUMAN (Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1)

HSP 1 Score: 181.415 bits (459), Expect = 5.491e-57
Identity = 86/138 (62.32%), Postives = 103/138 (74.64%), Query Frame = 3 
Query:  126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            ++   W + RLNHVAIAVPDLEKA   +++  GA+VS+  P  EHGV  VFV L N K+ELLHPLG +SPI  FL KNKAGG+HHIC+EVDNI  A+ DLK   +R+L +E KIGAHG PVIFLHPKD  GVL ELE+
Sbjct:   38 VTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 175
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q2KIZ3|MCEE_BOVIN (Methylmalonyl-CoA epimerase, mitochondrial OS=Bos taurus OX=9913 GN=MCEE PE=2 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 2.640e-56
Identity = 88/151 (58.28%), Postives = 106/151 (70.20%), Query Frame = 3 
Query:  111 SSFRTMSSKS--------WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            S+ RT +S S        W + RLNHVA+AVPDLEKA   +++  GA+V +P P  EHGV  VFV L N K+ELLHPLG +SPI  FL KNKAGG+HH+C+EVDNI  A+ DLK   +R L +E KIGAHG PVIFLHP D  GVL ELE+
Sbjct:   24 STVRTSASLSSHPGAGPVWNLGRLNHVAVAVPDLEKARAFYKNVLGAEVGEPVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPIAGFLKKNKAGGMHHVCIEVDNINVAVMDLKEKKIRILSEEAKIGAHGKPVIFLHPSDCGGVLVELEQ 174
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q553V2|MCEE_DICDI (Methylmalonyl-CoA epimerase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=mcee PE=3 SV=1)

HSP 1 Score: 177.948 bits (450), Expect = 1.052e-55
Identity = 92/166 (55.42%), Postives = 115/166 (69.28%), Query Frame = 3 
Query:   78 MFQKFAKLYLNSSFRTMSSKSWK------------VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            MF++  K  L +S R+ S+ +              + +LNHVAIA P+L+++  L+++ FGA VS+P  Q EHGV TVFV LEN KIELLHP GD SPI+NFL KN +GGIHHICLEVD+I  A+K L   NVR +   PKIGAHG PV+FLHPK +NGVL ELEE
Sbjct:    1 MFKQLIKTTLTNS-RSFSTNTGSGSKIGNIIGKIGIGKLNHVAIATPNLQESMDLYKNVFGADVSEPVNQVEHGVTTVFVGLENTKIELLHPFGDKSPIENFLKKNPSGGIHHICLEVDDIHHAVKTLLAENVRIIDPTPKIGAHGKPVVFLHPKSMNGVLVELEE 165
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q3IZP4|EPI_RHOS4 (Ethylmalonyl-CoA/methylmalonyl-CoA epimerase OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) OX=272943 GN=epi PE=1 SV=1)

HSP 1 Score: 162.925 bits (411), Expect = 3.265e-50
Identity = 80/132 (60.61%), Postives = 95/132 (71.97%), Query Frame = 3 
Query:  147 VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGD-EPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            + RLNHVAIAVPDLE A   +R+  GA+V  P+ + +HGV  +F+ L N KIELLHPLG+ SPI  FL+KN AGGIHHIC EV++I  A   LK    R LG  EPKIGAHG PV+FLHPKD NG L ELE+
Sbjct:    2 IGRLNHVAIAVPDLEAAAAQYRNTLGAEVGAPQDEPDHGVTVIFITLPNTKIELLHPLGEGSPIAGFLEKNPAGGIHHICYEVEDILAARDRLKEAGARVLGSGEPKIGAHGKPVLFLHPKDFNGCLVELEQ 133
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0V0J598 (Methylmalonyl-CoA epimerase OS=Schistocephalus solidus OX=70667 GN=MCEE PE=4 SV=1)

HSP 1 Score: 228.409 bits (581), Expect = 4.683e-73
Identity = 113/163 (69.33%), Postives = 127/163 (77.91%), Query Frame = 3 
Query:   75 SMFQKFAKL--YLNSSFRTMS--SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEEPKKS 551
            S FQ   K   +L S  R  S  SKSWK  RLNHVAIAVP+LEKA+  +RD  GAKVS PEPQ EHGVYTVFV+L+N K+ELL PLGD SPI  FL+KNKAGGIHHICL+V +IK A+KDL   NVRTLG EPK GAHGYPVIFLHPKD +GVLTELEEP ++
Sbjct:    2 SRFQSLRKFVPFLTSFTRQASAPSKSWKAMRLNHVAIAVPNLEKASAFYRDVIGAKVSAPEPQPEHGVYTVFVQLDNTKLELLSPLGDKSPIAGFLEKNKAGGIHHICLDVSDIKAAIKDLGAKNVRTLGAEPKTGAHGYPVIFLHPKDASGVLTELEEPDEA 164
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0V0JB28 (Methylmalonyl-CoA epimerase OS=Schistocephalus solidus OX=70667 GN=MCEE PE=4 SV=1)

HSP 1 Score: 224.557 bits (571), Expect = 1.177e-71
Identity = 111/161 (68.94%), Postives = 125/161 (77.64%), Query Frame = 3 
Query:   75 SMFQKFAKL--YLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEEPKKS 551
            S FQ   K   +L S  R    KSWK  RLNHVAIAVP+LEKA+  +RD  GAKVS PEPQ EHGVYTVFV+L+N K+ELL PLGD SPI  FL+KNKAGGIHHICL+V +IK A+KDL   NVRTLG EPK GAHGYPVIFLHPKD +GVLTELEEP ++
Sbjct:    2 SRFQSLRKFVPFLTSFTR---QKSWKAMRLNHVAIAVPNLEKASAFYRDVIGAKVSAPEPQPEHGVYTVFVQLDNTKLELLSPLGDKSPIAGFLEKNKAGGIHHICLDVSDIKAAIKDLGAKNVRTLGAEPKTGAHGYPVIFLHPKDASGVLTELEEPDEA 159
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: V4B256 (VOC domain-containing protein (Fragment) OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_140877 PE=4 SV=1)

HSP 1 Score: 206.453 bits (524), Expect = 6.552e-65
Identity = 96/133 (72.18%), Postives = 113/133 (84.96%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WKV ++NHVA+AVP++EKA  ++RD  GAKVS+  PQ+EHGVYTVFVEL   KIELLHPLGD SPI+NFLDKNK+GG+HHIC+EVDNI+EA+KD+K  N+RTL    KIGAHG PVIFLHPKD NGVL ELEE
Sbjct:    1 WKVGKINHVAMAVPNMEKAASMYRDVLGAKVSEKMPQEEHGVYTVFVELGETKIELLHPLGDESPIQNFLDKNKSGGMHHICIEVDNIEEAIKDMKAKNIRTLTPTSKIGAHGKPVIFLHPKDCNGVLVELEE 133
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A1Y1YNN2 (Mitochondrial methylmalonyl-CoA epimerase OS=Basidiobolus meristosporus CBS 931.73 OX=1314790 GN=K493DRAFT_313144 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 6.976e-65
Identity = 97/136 (71.32%), Postives = 111/136 (81.62%), Query Frame = 3 
Query:  132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            S  WK+  LNHVAIAVPDLE++TK +RD  GA+VS+  PQ EHGVYTVFV+L N KIELLHPLG+ SPI+NFLDKNK GGIHH+C+EVDNIK AM DL G  +RTL  EPKIGAHG PV+FLHPKD  GVL ELE+
Sbjct:   41 SAVWKLGHLNHVAIAVPDLEQSTKFYRDTLGAEVSEKMPQPEHGVYTVFVQLGNTKIELLHPLGEKSPIQNFLDKNKNGGIHHVCIEVDNIKNAMADLVGKKIRTLSSEPKIGAHGKPVVFLHPKDCGGVLVELEQ 176
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BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0P4WIM0 (VOC domain-containing protein OS=Scylla olivacea OX=85551 PE=4 SV=1)

HSP 1 Score: 204.912 bits (520), Expect = 1.035e-63
Identity = 95/133 (71.43%), Postives = 110/133 (82.71%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ RLNHVAIA PDLEK+T L+RD  GA+VS  E   EHGVYTVFV+L+N K+ELLHPLGDNSPI+NFLDKNK GG+HHIC+EV++I+ AMKDL   N+R L  EPKIGAHG PV+FLHPKD  GVL ELEE
Sbjct:   43 WKLGRLNHVAIATPDLEKSTALYRDVLGAEVSGVEALPEHGVYTVFVKLDNTKLELLHPLGDNSPIQNFLDKNKNGGMHHICIEVNDIQAAMKDLTAQNIRCLSKEPKIGAHGKPVVFLHPKDCAGVLVELEE 175
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Cavefish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368])

HSP 1 Score: 119.783 bits (299), Expect = 4.917e-34
Identity = 64/133 (48.12%), Postives = 77/133 (57.89%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ RLNHVAIAVPDLEK             S        G+Y V    E              P +  L KNK+GG+HHIC+EVD+I  A+ DLK  N+R L  EP+IGAHG PV+FLHPKD +GVL ELE+
Sbjct:   54 WKLGRLNHVAIAVPDLEK-------------SHSSVPGSRGLYCVCGAGEK-------------PHRRLLQKNKSGGMHHICIEVDDINTAIADLKVKNIRLLSAEPRIGAHGKPVMFLHPKDCDGVLVELEQ 160
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002282.1 (pep scaffold:Pmarinus_7.0:GL481448:2519:6766:-1 gene:ENSPMAG00000002080.1 transcript:ENSPMAT00000002282.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 181.8 bits (460), Expect = 3.542e-59
Identity = 83/139 (59.71%), Postives = 104/139 (74.82%), Query Frame = 3 
Query:  123 TMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
             +  + W + RLNHVA+AVP+LE AT+L+RD  GA+VS   P  EHGV TVFV+L N KIELL PLGD SPI  FL KN +GG+HH+CLEVD++  A+  ++   VR LG EP++GAHG PVIFLHPKD +GVL ELE+
Sbjct:    6 AVGERLWGLGRLNHVAVAVPNLEAATRLYRDVLGAQVSGVVPLPEHGVSTVFVDLGNTKIELLEPLGDKSPIAGFLAKNSSGGLHHVCLEVDDLTAALGAVRAMGVRPLGSEPRVGAHGKPVIFLHPKDCSGVLVELEQ 144
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:101169277])

HSP 1 Score: 199.904 bits (507), Expect = 2.612e-65
Identity = 91/133 (68.42%), Postives = 108/133 (81.20%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ +LNH+AIAVPD+E+AT L+RD  GA VS   P  EHGVYTVFVEL N K+ELLHPLGD SPI  FL KNK+GG+HHIC+EVD+IK A+ D+K  N+RTL  EP+IGAHG PV+FLHPKD +GVL ELEE
Sbjct:   38 WKLGKLNHIAIAVPDMERATALYRDVLGATVSDKVPLPEHGVYTVFVELGNTKLELLHPLGDKSPISGFLQKNKSGGMHHICIEVDDIKAAVADMKAKNIRTLSAEPRIGAHGKPVMFLHPKDCDGVLVELEE 170
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:101169277])

HSP 1 Score: 199.134 bits (505), Expect = 8.630e-65
Identity = 91/133 (68.42%), Postives = 108/133 (81.20%), Query Frame = 3 
Query:  141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539
            WK+ +LNH+AIAVPD+E+AT L+RD  GA VS   P  EHGVYTVFVEL N K+ELLHPLGD SPI  FL KNK+GG+HHIC+EVD+IK A+ D+K  N+RTL  EP+IGAHG PV+FLHPKD +GVL ELEE
Sbjct:   51 WKLGKLNHIAIAVPDMERATALYRDVLGATVSDKVPLPEHGVYTVFVELGNTKLELLHPLGDKSPISGFLQKNKSGGMHHICIEVDDIKAAVADMKAKNIRTLSAEPRIGAHGKPVMFLHPKDCDGVLVELEE 183
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BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1)

HSP 1 Score: 249.21 bits (635), Expect = 2.695e-85
Identity = 120/121 (99.17%), Postives = 121/121 (100.00%), Query Frame = 3 
Query:   78 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNV 440
            MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHN+
Sbjct:    1 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNL 121
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1)

HSP 1 Score: 214.542 bits (545), Expect = 6.865e-72
Identity = 104/105 (99.05%), Postives = 105/105 (100.00%), Query Frame = 3 
Query:  126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNV 440
            MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHN+
Sbjct:    1 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNL 105
[Close]
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1)

HSP 1 Score: 158.303 bits (399), Expect = 5.231e-50
Identity = 77/81 (95.06%), Postives = 77/81 (95.06%), Query Frame = 3 
Query:   78 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPL 320
            MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIE    L
Sbjct:    1 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIECFEYL 81
The following BLAST results are available for this feature:
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
MCEE1.143e-5762.32methylmalonyl-CoA epimerase [Source:HGNC Symbol;Ac... [more]
MCEE4.560e-1738.76methylmalonyl-CoA epimerase [Source:HGNC Symbol;Ac... [more]
MCEE1.016e-974.19methylmalonyl-CoA epimerase [Source:HGNC Symbol;Ac... [more]
MCEE1.016e-974.19methylmalonyl-CoA epimerase [Source:HGNC Symbol;Ac... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mce-11.840e-5659.60Methylmalonyl-CoA Epimerase; Mitochondrial methylm... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mcee2.410e-6268.42methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-G... [more]
mcee2.597e-6268.42methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mcee1.436e-6267.65methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:... [more]
mcee1.654e-6267.65methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Mcee1.183e-6165.69methylmalonyl CoA epimerase [Source:MGI Symbol;Acc... [more]
Mcee1.013e-2240.15methylmalonyl CoA epimerase [Source:MGI Symbol;Acc... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9D1I5|MCEE_MOUSE8.272e-6165.69Methylmalonyl-CoA epimerase, mitochondrial OS=Mus ... [more]
sp|Q96PE7|MCEE_HUMAN5.491e-5762.32Methylmalonyl-CoA epimerase, mitochondrial OS=Homo... [more]
sp|Q2KIZ3|MCEE_BOVIN2.640e-5658.28Methylmalonyl-CoA epimerase, mitochondrial OS=Bos ... [more]
sp|Q553V2|MCEE_DICDI1.052e-5555.42Methylmalonyl-CoA epimerase, mitochondrial OS=Dict... [more]
sp|Q3IZP4|EPI_RHOS43.265e-5060.61Ethylmalonyl-CoA/methylmalonyl-CoA epimerase OS=Rh... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0V0J5984.683e-7369.33Methylmalonyl-CoA epimerase OS=Schistocephalus sol... [more]
A0A0V0JB281.177e-7168.94Methylmalonyl-CoA epimerase OS=Schistocephalus sol... [more]
V4B2566.552e-6572.18VOC domain-containing protein (Fragment) OS=Lottia... [more]
A0A1Y1YNN26.976e-6571.32Mitochondrial methylmalonyl-CoA epimerase OS=Basid... [more]
A0A0P4WIM01.035e-6371.43VOC domain-containing protein OS=Scylla olivacea O... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mcee4.917e-3448.12methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000002282.13.542e-5959.71pep scaffold:Pmarinus_7.0:GL481448:2519:6766:-1 ge... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mcee2.612e-6568.42methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:... [more]
mcee8.630e-6568.42methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:... [more]
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BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000021684.12.695e-8599.17SMESG000021684.1[more]
SMESG000021684.16.865e-7299.05SMESG000021684.1[more]
SMESG000021684.15.231e-5095.06SMESG000021684.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007072 ID=SMED30007072|Name=Methylmalonyl-CoA epimerase|organism=Schmidtea mediterranea sexual|type=transcript|length=651bp
CATTTTCAATATTACAATTTTAAAAAAAATCAATTTTTTTTTACGTGACC
TTAGTTTCATAATTTCATAACTAGTCAATGTTTCAGAAATTCGCGAAGTT
GTATTTAAACAGTTCTTTTAGAACAATGAGTTCTAAATCGTGGAAAGTAA
CTCGCTTAAATCACGTCGCAATTGCTGTTCCTGATTTAGAAAAGGCAACC
AAGTTATTCCGTGATGCTTTTGGGGCCAAAGTCAGCAAACCAGAGCCACA
GAAAGAACACGGAGTCTACACAGTCTTTGTTGAACTAGAAAATGCCAAGA
TTGAGCTTTTGCATCCATTGGGTGATAATAGTCCAATAAAAAACTTTCTA
GACAAAAATAAAGCAGGTGGTATCCATCATATATGTTTAGAAGTGGATAA
TATTAAAGAGGCAATGAAAGATTTAAAAGGTCATAATGTGAGAACTCTTG
GTGACGAACCAAAAATTGGAGCTCATGGATATCCAGTTATATTTCTTCAT
CCCAAAGATGTTAATGGTGTTCTTACTGAGTTAGAAGAACCTAAAAAATC
ATAATGCAATGCTTTCCTTTGATTTATAAAATTATAAACATATATATGCT
CTTATAAAGTAAAGTTTTTTATAAAATAAACATTTAGAATAAAAATTTTT
T
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protein sequence of SMED30007072-orf-1

>SMED30007072-orf-1 ID=SMED30007072-orf-1|Name=SMED30007072-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=159bp
MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGA
KVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIH
HICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLT
ELEEPKKS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000101muscle cell
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR017515MeMalonyl-CoA_epimerase
IPR037523VOC
IPR029068Glyas_Bleomycin-R_OHBP_Dase
Vocabulary: molecular function
TermDefinition
GO:0004493methylmalonyl-CoA epimerase activity
GO:0016853isomerase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
Vocabulary: biological process
TermDefinition
GO:0046491L-methylmalonyl-CoA metabolic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePFAMPF13669Glyoxalase_4coord: 28..139
e-value: 4.0E-21
score: 75.3
NoneNo IPR availablePANTHERPTHR43048METHYLMALONYL-COA EPIMERASEcoord: 12..157
NoneNo IPR availablePANTHERPTHR43048:SF3METHYLMALONYL-COA EPIMERASE, MITOCHONDRIALcoord: 12..157
IPR017515Methylmalonyl-CoA epimeraseTIGRFAMTIGR03081TIGR03081coord: 26..154
e-value: 1.9E-56
score: 188.1
IPR017515Methylmalonyl-CoA epimeraseCDDcd07249MMCEcoord: 27..154
e-value: 9.69232E-63
score: 187.013
IPR029068Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenaseGENE3DG3DSA:3.10.180.10coord: 20..154
e-value: 6.4E-39
score: 135.0
IPR029068Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenaseSUPERFAMILYSSF54593Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenasecoord: 21..156
IPR037523Vicinal oxygen chelate (VOC) domainPROSITEPS51819VOCcoord: 26..155
score: 25.721