Methylmalonyl-CoA epimerase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30007072 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732]) HSP 1 Score: 181.415 bits (459), Expect = 1.143e-57 Identity = 86/138 (62.32%), Postives = 103/138 (74.64%), Query Frame = 3 Query: 126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 ++ W + RLNHVAIAVPDLEKA +++ GA+VS+ P EHGV VFV L N K+ELLHPLG +SPI FL KNKAGG+HHIC+EVDNI A+ DLK +R+L +E KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 38 VTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 175
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732]) HSP 1 Score: 74.3294 bits (181), Expect = 4.560e-17 Identity = 50/129 (38.76%), Postives = 57/129 (44.19%), Query Frame = 3 Query: 153 RLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 RLNHVAIAVPDLEKA + KN L +VDNI A+ DLK +R+L +E KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 3 RLNHVAIAVPDLEKAAAFY-------------------------------------------KNILGA-----------QVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 77
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732]) HSP 1 Score: 53.5286 bits (127), Expect = 1.016e-9 Identity = 23/31 (74.19%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 300 IELLHPLGDNSPIKNFLDKNKAGGIHHICLE 392 +ELLHPLG +SPI FL KNKAGG+HHIC+E Sbjct: 1 MELLHPLGRDSPIAGFLQKNKAGGMHHICIE 31
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Match: MCEE (methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732]) HSP 1 Score: 53.5286 bits (127), Expect = 1.016e-9 Identity = 23/31 (74.19%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 300 IELLHPLGDNSPIKNFLDKNKAGGIHHICLE 392 +ELLHPLG +SPI FL KNKAGG+HHIC+E Sbjct: 1 MELLHPLGRDSPIAGFLQKNKAGGMHHICIE 31
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Celegans
Match: mce-1 (Methylmalonyl-CoA Epimerase; Mitochondrial methylmalonyl-CoA epimerase [Source:UniProtKB/TrEMBL;Acc:G5EEG4]) HSP 1 Score: 176.792 bits (447), Expect = 1.840e-56 Identity = 90/151 (59.60%), Postives = 116/151 (76.82%), Query Frame = 3 Query: 93 AKLYLNSSFRTMSSKSWK--VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 AKL L++ RTM+S + +LNHVAIA PDL+K+++ ++ GAKVS+ PQ EHGVYTVFVEL N+KIELLHP G+ SPI+ FL+KNK GG+HHIC+EV +I EA+ +K +RTLG++PKIGAHG V+FLHPKD GVL ELE+ Sbjct: 14 AKLSLST--RTMASHPLAGLLGKLNHVAIATPDLKKSSEFYK-GLGAKVSEAVPQPEHGVYTVFVELPNSKIELLHPFGEKSPIQAFLNKNKDGGMHHICIEVRDIHEAVSAVKTKGIRTLGEKPKIGAHGKEVMFLHPKDCGGVLIELEQ 161
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368]) HSP 1 Score: 192.971 bits (489), Expect = 2.410e-62 Identity = 91/133 (68.42%), Postives = 106/133 (79.70%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ RLNHVAIAVPDLEKAT L+RD GA+VS P EHGVYTVFVEL N K+ELLHPLG+ SPI FL KNKAGG+HHIC+EVD+I A+ DLK +R L EP+IGAHG PV+FLHPKD +GVL E+E+ Sbjct: 42 WKLGRLNHVAIAVPDLEKATALYRDVLGAQVSDTVPLPEHGVYTVFVELGNTKLELLHPLGEKSPIAGFLQKNKAGGMHHICIEVDDINAAIVDLKEKKIRLLSPEPRIGAHGKPVMFLHPKDCDGVLVEIEQ 174
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368]) HSP 1 Score: 193.356 bits (490), Expect = 2.597e-62 Identity = 91/133 (68.42%), Postives = 106/133 (79.70%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ RLNHVAIAVPDLEKAT L+RD GA+VS P EHGVYTVFVEL N K+ELLHPLG+ SPI FL KNKAGG+HHIC+EVD+I A+ DLK +R L EP+IGAHG PV+FLHPKD +GVL E+E+ Sbjct: 59 WKLGRLNHVAIAVPDLEKATALYRDVLGAQVSDTVPLPEHGVYTVFVELGNTKLELLHPLGEKSPIAGFLQKNKAGGMHHICIEVDDINAAIVDLKEKKIRLLSPEPRIGAHGKPVMFLHPKDCDGVLVEIEQ 191
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:448311]) HSP 1 Score: 193.741 bits (491), Expect = 1.436e-62 Identity = 92/136 (67.65%), Postives = 105/136 (77.21%), Query Frame = 3 Query: 132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 S W + RLNHVAIAVPDLEKA L+ GA+VSK P EHGVYTVFVEL N K+ELLHPLG NSPI FL KNKAGG+HHIC+EVD+IK AM LK ++ L +EP+IGAHG PV+FLHPKD +GVL ELEE Sbjct: 38 SSVWNLGRLNHVAIAVPDLEKACFLYEKVLGAQVSKTVPLPEHGVYTVFVELGNTKLELLHPLGQNSPISGFLQKNKAGGLHHICIEVDDIKAAMTSLKEKKIKILSEEPRIGAHGKPVVFLHPKDCDGVLVELEE 173
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:448311]) HSP 1 Score: 193.741 bits (491), Expect = 1.654e-62 Identity = 92/136 (67.65%), Postives = 105/136 (77.21%), Query Frame = 3 Query: 132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 S W + RLNHVAIAVPDLEKA L+ GA+VSK P EHGVYTVFVEL N K+ELLHPLG NSPI FL KNKAGG+HHIC+EVD+IK AM LK ++ L +EP+IGAHG PV+FLHPKD +GVL ELEE Sbjct: 38 SSVWNLGRLNHVAIAVPDLEKACFLYEKVLGAQVSKTVPLPEHGVYTVFVELGNTKLELLHPLGQNSPISGFLQKNKAGGLHHICIEVDDIKAAMTSLKEKKIKILSEEPRIGAHGKPVVFLHPKDCDGVLVELEE 173
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Match: Mcee (methylmalonyl CoA epimerase [Source:MGI Symbol;Acc:MGI:1920974]) HSP 1 Score: 191.43 bits (485), Expect = 1.183e-61 Identity = 90/137 (65.69%), Postives = 105/137 (76.64%), Query Frame = 3 Query: 129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 SS WK+ RLNHVA+AVPDLEKA+ +RD GA+VS+ P EHGV VFV L N K+ELLHPLG +SPI FL KNKAGG+HH+C+EVDNI A+ DLK +R+L DE KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQVSEVVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPITGFLQKNKAGGMHHVCIEVDNISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 177
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Match: Mcee (methylmalonyl CoA epimerase [Source:MGI Symbol;Acc:MGI:1920974]) HSP 1 Score: 89.7373 bits (221), Expect = 1.013e-22 Identity = 55/137 (40.15%), Postives = 64/137 (46.72%), Query Frame = 3 Query: 129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 SS WK+ RLNHVA+AVPDLEKA+ +RD GA+V DN I A+ DLK +R+L DE KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQV------------------------------DN------------------------ISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 123
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q9D1I5|MCEE_MOUSE (Methylmalonyl-CoA epimerase, mitochondrial OS=Mus musculus OX=10090 GN=Mcee PE=1 SV=1) HSP 1 Score: 191.43 bits (485), Expect = 8.272e-61 Identity = 90/137 (65.69%), Postives = 105/137 (76.64%), Query Frame = 3 Query: 129 SSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 SS WK+ RLNHVA+AVPDLEKA+ +RD GA+VS+ P EHGV VFV L N K+ELLHPLG +SPI FL KNKAGG+HH+C+EVDNI A+ DLK +R+L DE KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 41 SSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQVSEVVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPITGFLQKNKAGGMHHVCIEVDNISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQ 177
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q96PE7|MCEE_HUMAN (Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1) HSP 1 Score: 181.415 bits (459), Expect = 5.491e-57 Identity = 86/138 (62.32%), Postives = 103/138 (74.64%), Query Frame = 3 Query: 126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 ++ W + RLNHVAIAVPDLEKA +++ GA+VS+ P EHGV VFV L N K+ELLHPLG +SPI FL KNKAGG+HHIC+EVDNI A+ DLK +R+L +E KIGAHG PVIFLHPKD GVL ELE+ Sbjct: 38 VTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQ 175
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q2KIZ3|MCEE_BOVIN (Methylmalonyl-CoA epimerase, mitochondrial OS=Bos taurus OX=9913 GN=MCEE PE=2 SV=1) HSP 1 Score: 179.874 bits (455), Expect = 2.640e-56 Identity = 88/151 (58.28%), Postives = 106/151 (70.20%), Query Frame = 3 Query: 111 SSFRTMSSKS--------WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 S+ RT +S S W + RLNHVA+AVPDLEKA +++ GA+V +P P EHGV VFV L N K+ELLHPLG +SPI FL KNKAGG+HH+C+EVDNI A+ DLK +R L +E KIGAHG PVIFLHP D GVL ELE+ Sbjct: 24 STVRTSASLSSHPGAGPVWNLGRLNHVAVAVPDLEKARAFYKNVLGAEVGEPVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPIAGFLKKNKAGGMHHVCIEVDNINVAVMDLKEKKIRILSEEAKIGAHGKPVIFLHPSDCGGVLVELEQ 174
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q553V2|MCEE_DICDI (Methylmalonyl-CoA epimerase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=mcee PE=3 SV=1) HSP 1 Score: 177.948 bits (450), Expect = 1.052e-55 Identity = 92/166 (55.42%), Postives = 115/166 (69.28%), Query Frame = 3 Query: 78 MFQKFAKLYLNSSFRTMSSKSWK------------VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 MF++ K L +S R+ S+ + + +LNHVAIA P+L+++ L+++ FGA VS+P Q EHGV TVFV LEN KIELLHP GD SPI+NFL KN +GGIHHICLEVD+I A+K L NVR + PKIGAHG PV+FLHPK +NGVL ELEE Sbjct: 1 MFKQLIKTTLTNS-RSFSTNTGSGSKIGNIIGKIGIGKLNHVAIATPNLQESMDLYKNVFGADVSEPVNQVEHGVTTVFVGLENTKIELLHPFGDKSPIENFLKKNPSGGIHHICLEVDDIHHAVKTLLAENVRIIDPTPKIGAHGKPVVFLHPKSMNGVLVELEE 165
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Match: sp|Q3IZP4|EPI_RHOS4 (Ethylmalonyl-CoA/methylmalonyl-CoA epimerase OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) OX=272943 GN=epi PE=1 SV=1) HSP 1 Score: 162.925 bits (411), Expect = 3.265e-50 Identity = 80/132 (60.61%), Postives = 95/132 (71.97%), Query Frame = 3 Query: 147 VTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGD-EPKIGAHGYPVIFLHPKDVNGVLTELEE 539 + RLNHVAIAVPDLE A +R+ GA+V P+ + +HGV +F+ L N KIELLHPLG+ SPI FL+KN AGGIHHIC EV++I A LK R LG EPKIGAHG PV+FLHPKD NG L ELE+ Sbjct: 2 IGRLNHVAIAVPDLEAAAAQYRNTLGAEVGAPQDEPDHGVTVIFITLPNTKIELLHPLGEGSPIAGFLEKNPAGGIHHICYEVEDILAARDRLKEAGARVLGSGEPKIGAHGKPVLFLHPKDFNGCLVELEQ 133
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0V0J598 (Methylmalonyl-CoA epimerase OS=Schistocephalus solidus OX=70667 GN=MCEE PE=4 SV=1) HSP 1 Score: 228.409 bits (581), Expect = 4.683e-73 Identity = 113/163 (69.33%), Postives = 127/163 (77.91%), Query Frame = 3 Query: 75 SMFQKFAKL--YLNSSFRTMS--SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEEPKKS 551 S FQ K +L S R S SKSWK RLNHVAIAVP+LEKA+ +RD GAKVS PEPQ EHGVYTVFV+L+N K+ELL PLGD SPI FL+KNKAGGIHHICL+V +IK A+KDL NVRTLG EPK GAHGYPVIFLHPKD +GVLTELEEP ++ Sbjct: 2 SRFQSLRKFVPFLTSFTRQASAPSKSWKAMRLNHVAIAVPNLEKASAFYRDVIGAKVSAPEPQPEHGVYTVFVQLDNTKLELLSPLGDKSPIAGFLEKNKAGGIHHICLDVSDIKAAIKDLGAKNVRTLGAEPKTGAHGYPVIFLHPKDASGVLTELEEPDEA 164
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0V0JB28 (Methylmalonyl-CoA epimerase OS=Schistocephalus solidus OX=70667 GN=MCEE PE=4 SV=1) HSP 1 Score: 224.557 bits (571), Expect = 1.177e-71 Identity = 111/161 (68.94%), Postives = 125/161 (77.64%), Query Frame = 3 Query: 75 SMFQKFAKL--YLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEEPKKS 551 S FQ K +L S R KSWK RLNHVAIAVP+LEKA+ +RD GAKVS PEPQ EHGVYTVFV+L+N K+ELL PLGD SPI FL+KNKAGGIHHICL+V +IK A+KDL NVRTLG EPK GAHGYPVIFLHPKD +GVLTELEEP ++ Sbjct: 2 SRFQSLRKFVPFLTSFTR---QKSWKAMRLNHVAIAVPNLEKASAFYRDVIGAKVSAPEPQPEHGVYTVFVQLDNTKLELLSPLGDKSPIAGFLEKNKAGGIHHICLDVSDIKAAIKDLGAKNVRTLGAEPKTGAHGYPVIFLHPKDASGVLTELEEPDEA 159
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: V4B256 (VOC domain-containing protein (Fragment) OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_140877 PE=4 SV=1) HSP 1 Score: 206.453 bits (524), Expect = 6.552e-65 Identity = 96/133 (72.18%), Postives = 113/133 (84.96%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WKV ++NHVA+AVP++EKA ++RD GAKVS+ PQ+EHGVYTVFVEL KIELLHPLGD SPI+NFLDKNK+GG+HHIC+EVDNI+EA+KD+K N+RTL KIGAHG PVIFLHPKD NGVL ELEE Sbjct: 1 WKVGKINHVAMAVPNMEKAASMYRDVLGAKVSEKMPQEEHGVYTVFVELGETKIELLHPLGDESPIQNFLDKNKSGGMHHICIEVDNIEEAIKDMKAKNIRTLTPTSKIGAHGKPVIFLHPKDCNGVLVELEE 133
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A1Y1YNN2 (Mitochondrial methylmalonyl-CoA epimerase OS=Basidiobolus meristosporus CBS 931.73 OX=1314790 GN=K493DRAFT_313144 PE=4 SV=1) HSP 1 Score: 207.994 bits (528), Expect = 6.976e-65 Identity = 97/136 (71.32%), Postives = 111/136 (81.62%), Query Frame = 3 Query: 132 SKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 S WK+ LNHVAIAVPDLE++TK +RD GA+VS+ PQ EHGVYTVFV+L N KIELLHPLG+ SPI+NFLDKNK GGIHH+C+EVDNIK AM DL G +RTL EPKIGAHG PV+FLHPKD GVL ELE+ Sbjct: 41 SAVWKLGHLNHVAIAVPDLEQSTKFYRDTLGAEVSEKMPQPEHGVYTVFVQLGNTKIELLHPLGEKSPIQNFLDKNKNGGIHHVCIEVDNIKNAMADLVGKKIRTLSSEPKIGAHGKPVVFLHPKDCGGVLVELEQ 176
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Match: A0A0P4WIM0 (VOC domain-containing protein OS=Scylla olivacea OX=85551 PE=4 SV=1) HSP 1 Score: 204.912 bits (520), Expect = 1.035e-63 Identity = 95/133 (71.43%), Postives = 110/133 (82.71%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ RLNHVAIA PDLEK+T L+RD GA+VS E EHGVYTVFV+L+N K+ELLHPLGDNSPI+NFLDKNK GG+HHIC+EV++I+ AMKDL N+R L EPKIGAHG PV+FLHPKD GVL ELEE Sbjct: 43 WKLGRLNHVAIATPDLEKSTALYRDVLGAEVSGVEALPEHGVYTVFVKLDNTKLELLHPLGDNSPIQNFLDKNKNGGMHHICIEVNDIQAAMKDLTAQNIRCLSKEPKIGAHGKPVVFLHPKDCAGVLVELEE 175
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Cavefish
Match: mcee (methylmalonyl CoA epimerase [Source:ZFIN;Acc:ZDB-GENE-050522-368]) HSP 1 Score: 119.783 bits (299), Expect = 4.917e-34 Identity = 64/133 (48.12%), Postives = 77/133 (57.89%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ RLNHVAIAVPDLEK S G+Y V E P + L KNK+GG+HHIC+EVD+I A+ DLK N+R L EP+IGAHG PV+FLHPKD +GVL ELE+ Sbjct: 54 WKLGRLNHVAIAVPDLEK-------------SHSSVPGSRGLYCVCGAGEK-------------PHRRLLQKNKSGGMHHICIEVDDINTAIADLKVKNIRLLSAEPRIGAHGKPVMFLHPKDCDGVLVELEQ 160
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002282.1 (pep scaffold:Pmarinus_7.0:GL481448:2519:6766:-1 gene:ENSPMAG00000002080.1 transcript:ENSPMAT00000002282.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 181.8 bits (460), Expect = 3.542e-59 Identity = 83/139 (59.71%), Postives = 104/139 (74.82%), Query Frame = 3 Query: 123 TMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 + + W + RLNHVA+AVP+LE AT+L+RD GA+VS P EHGV TVFV+L N KIELL PLGD SPI FL KN +GG+HH+CLEVD++ A+ ++ VR LG EP++GAHG PVIFLHPKD +GVL ELE+ Sbjct: 6 AVGERLWGLGRLNHVAVAVPNLEAATRLYRDVLGAQVSGVVPLPEHGVSTVFVDLGNTKIELLEPLGDKSPIAGFLAKNSSGGLHHVCLEVDDLTAALGAVRAMGVRPLGSEPRVGAHGKPVIFLHPKDCSGVLVELEQ 144
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:101169277]) HSP 1 Score: 199.904 bits (507), Expect = 2.612e-65 Identity = 91/133 (68.42%), Postives = 108/133 (81.20%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ +LNH+AIAVPD+E+AT L+RD GA VS P EHGVYTVFVEL N K+ELLHPLGD SPI FL KNK+GG+HHIC+EVD+IK A+ D+K N+RTL EP+IGAHG PV+FLHPKD +GVL ELEE Sbjct: 38 WKLGKLNHIAIAVPDMERATALYRDVLGATVSDKVPLPEHGVYTVFVELGNTKLELLHPLGDKSPISGFLQKNKSGGMHHICIEVDDIKAAVADMKAKNIRTLSAEPRIGAHGKPVMFLHPKDCDGVLVELEE 170
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Match: mcee (methylmalonyl-CoA epimerase [Source:NCBI gene;Acc:101169277]) HSP 1 Score: 199.134 bits (505), Expect = 8.630e-65 Identity = 91/133 (68.42%), Postives = 108/133 (81.20%), Query Frame = 3 Query: 141 WKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNVRTLGDEPKIGAHGYPVIFLHPKDVNGVLTELEE 539 WK+ +LNH+AIAVPD+E+AT L+RD GA VS P EHGVYTVFVEL N K+ELLHPLGD SPI FL KNK+GG+HHIC+EVD+IK A+ D+K N+RTL EP+IGAHG PV+FLHPKD +GVL ELEE Sbjct: 51 WKLGKLNHIAIAVPDMERATALYRDVLGATVSDKVPLPEHGVYTVFVELGNTKLELLHPLGDKSPISGFLQKNKSGGMHHICIEVDDIKAAVADMKAKNIRTLSAEPRIGAHGKPVMFLHPKDCDGVLVELEE 183
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1) HSP 1 Score: 249.21 bits (635), Expect = 2.695e-85 Identity = 120/121 (99.17%), Postives = 121/121 (100.00%), Query Frame = 3 Query: 78 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNV 440 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHN+ Sbjct: 1 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNL 121
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1) HSP 1 Score: 214.542 bits (545), Expect = 6.865e-72 Identity = 104/105 (99.05%), Postives = 105/105 (100.00%), Query Frame = 3 Query: 126 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNV 440 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHN+ Sbjct: 1 MSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPLGDNSPIKNFLDKNKAGGIHHICLEVDNIKEAMKDLKGHNL 105
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Match: SMESG000021684.1 (SMESG000021684.1) HSP 1 Score: 158.303 bits (399), Expect = 5.231e-50 Identity = 77/81 (95.06%), Postives = 77/81 (95.06%), Query Frame = 3 Query: 78 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIELLHPL 320 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIE L Sbjct: 1 MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAKVSKPEPQKEHGVYTVFVELENAKIECFEYL 81 The following BLAST results are available for this feature:
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 4
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Methylmalonyl-CoA epimerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Methylmalonyl-CoA epimerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Methylmalonyl-CoA epimerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Methylmalonyl-CoA epimerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30007072 ID=SMED30007072|Name=Methylmalonyl-CoA epimerase|organism=Schmidtea mediterranea sexual|type=transcript|length=651bpback to top protein sequence of SMED30007072-orf-1 >SMED30007072-orf-1 ID=SMED30007072-orf-1|Name=SMED30007072-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=159bp MFQKFAKLYLNSSFRTMSSKSWKVTRLNHVAIAVPDLEKATKLFRDAFGAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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