Eukaryotic translation initiation factor 2-alpha kinase 3

Overview
NameEukaryotic translation initiation factor 2-alpha kinase 3
Smed IDSMED30006989
Length (bp)2977
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Eukaryotic translation initiation factor 2-alpha kinase 3 (SMED30006989) t-SNE clustered cells

Violin plots show distribution of expression levels for Eukaryotic translation initiation factor 2-alpha kinase 3 (SMED30006989) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Eukaryotic translation initiation factor 2-alpha kinase 3 (SMED30006989) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Eukaryotic translation initiation factor 2-alpha kinase 3 (SMED30006989) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30006989

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 14

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30006989h1SMcG0016514 dd_Smed_v4_5111_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Match: EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255])

HSP 1 Score: 146.747 bits (369), Expect = 4.354e-35
Identity = 88/230 (38.26%), Postives = 122/230 (53.04%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            +YLYI M L    +LKDW+  + T    R  + CL HIF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +   +  ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER   LT  R ++F P  T  +P E    +                       +L+P P +RP    I  + +  D+
Sbjct:  882 VYLYIQMQLCRKENLKDWMNGRCTI-EERERSVCL-HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV-LTPMPAYARH-----TGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQD----------------------MLSPSPMERPEAINIIENAVFEDL 1080

HSP 2 Score: 129.028 bits (323), Expect = 1.577e-29
Identity = 69/160 (43.12%), Postives = 96/160 (60.00%), Query Frame = 1 
Query: 1330 IFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            I FC++   F  I  R++ P+   +    ++         Q  N   S S     G A D S  + ++    Y SRY TD+E I+CLG+G FGVVFEA+++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  529 ILFCIIATTF--IVRRLFHPHPHRQRKESETQ-------CQTENKYDSVS-----GEANDSS--WNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDE 672

HSP 3 Score: 105.531 bits (262), Expect = 2.219e-22
Identity = 79/299 (26.42%), Postives = 146/299 (48.83%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL----DKDSYPQSPLGEGGAVINSGCVLVQDSRDPG--NVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR----IEQIQDEFGCPR---RRSLFLGAYQGHMYVQ 1041
            +++IS++DG +  ++ EN G+  W++        S S  +      K  +IPSL+G L+  + D D   +  +P T ++L  S+++   D +LVGGK    +G + ++G+V+Y C   GC Q  S    ++  D+L+ +R    VRAV    G EKWNFSVG  ++  +     +  + +S          S  +   + ++    ++    +V + ++ A  K   H + W+ Q    ++  WL+ +G V  ++LF   S+      +E  +D     R     S++LG Y+G +Y+Q
Sbjct:  105 LVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKM-IIPSLDGALF--QWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEE-DILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGH-LEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQ 398
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687])

HSP 1 Score: 118.242 bits (295), Expect = 3.841e-26
Identity = 84/234 (35.90%), Postives = 115/234 (49.15%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSAD------VSALPSGSHGDSQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +       R T R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D      + + PSG       LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  797 YLYIQMEYCEKSTLRDTIDQG----LYRDTVR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSG------HLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPEDFDDGEHAK-------------QKSVISWLLNHDPAKRPTATELLKSELL 1001

HSP 2 Score: 65.855 bits (159), Expect = 4.107e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  584 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIE 657
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687])

HSP 1 Score: 112.079 bits (279), Expect = 2.497e-24
Identity = 77/207 (37.20%), Postives = 104/207 (50.24%), Query Frame = 1 
Query: 2194 RPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSAD------VSALPSGSHGDSQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            R T R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D      + + PSG       LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  598 RDTVR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSG------HLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPEDFDDGEHAK-------------QKSVISWLLNHDPAKRPTATELLKSELL 779

HSP 2 Score: 66.2402 bits (160), Expect = 3.568e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  390 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIE 463
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Match: EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:HGNC Symbol;Acc:HGNC:24921])

HSP 1 Score: 103.219 bits (256), Expect = 6.840e-22
Identity = 67/191 (35.08%), Postives = 97/191 (50.79%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQT--------SPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDN-QNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRF 2652
            H+ L+I M L    SL DW+ E+          S            IF ++V+ V Y+H+ G++HRDLKP NI        ++I DFGLA + +  K     + +   + +H      TS VGT LY SPEQ + G+ YD K D++SLG++ +EL  P  T MERA VLT  R  Q    +    P + ++
Sbjct:  377 HLMLHIQMQL-CELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTH------TSRVGTCLYASPEQLE-GSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKY 559

HSP 2 Score: 67.781 bits (164), Expect = 7.522e-11
Identity = 30/75 (40.00%), Postives = 50/75 (66.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARS-KLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E +  LGKG +G V++ R+++D   YA+K++ ++ + +    K+L+EVK  A L+HP IV Y+ AW E
Sbjct:  161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Match: EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437])

HSP 1 Score: 83.1889 bits (204), Expect = 8.255e-16
Identity = 51/161 (31.68%), Postives = 77/161 (47.83%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKAR 2598
            L+I M      +L+ W+++++     +      L +F QI   V Y+HS  L+HRDLKPSNI   +   ++I DFGL TS+                    +    T + GT  YMSPEQ      Y ++VD+++LG+I  EL+    T  E +   T  R
Sbjct:  321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLA---LELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK-------------------NDGKRTRSKGTLRYMSPEQISS-QDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR 458
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Match: pek-1 (Eukaryotic translation initiation factor 2-alpha kinase pek-1 [Source:UniProtKB/Swiss-Prot;Acc:Q19192])

HSP 1 Score: 103.219 bits (256), Expect = 5.352e-22
Identity = 69/254 (27.17%), Postives = 125/254 (49.21%), Query Frame = 1 
Query:  181 IRILLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIK-DAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGC-EQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALF 936
            + I++ +++DG +  ++ E G+++W  ++ PL+  +LS  + I       +L+P+L+G+L+      + N +  LPIT D+L  ST +L  D++  GGK     GF+ FTGE KY C  + C   D+  P+      +++ RR ++ +RA+D   G+E+WN S  +  V      + P                LV D      VK      +G I A+ K  ++R  WK  ++  +   W V    + ++++F
Sbjct:   53 VNIIITATLDGVVTALDGETGEMIWRYEDAPLLRGTLSTSDPIDIGGTSLQLMPTLDGRLF--SYTHNTNLIEPLPITTDSLLESTIRLGQDAV-AGGKSVTTKGFDLFTGEQKYECSMESCGPGDTETPKNP----IILIRRTTNSIRAMDTLRGIERWNLSTAEIGVTLAGGITSP---------------TLVSD------VKILLQPPDGVIVAVDK--YNREEWKTNVDGHIVSVWQVYGNQIGEISIF 276

HSP 2 Score: 100.138 bits (248), Expect = 3.814e-21
Identity = 70/225 (31.11%), Postives = 110/225 (48.89%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFD-NQNH----IRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQI 2772
            YLYI M L + ++L+DW++  +T  + RP    + +   Q+   + YLH+ G +HRDLKP N+ F  +  H    ++I D GLAT      P  +    +  S  H      T NVGT  YMSPEQ +   +Y +KVD+F+LG++  EL++  ST  ER       ++    P + D+ P E R                     +F  +L + +P +RPT  ++
Sbjct:  879 YLYIVMQLCAEKTLEDWIRRSKTMES-RPLF-TMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATK-TDGAPKITVRQDSDSSAKH------TKNVGTRSYMSPEQLKH-QQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKGDI-PAILDNVP-ESR---------------------DFLLQLTSLEPSERPTAHEV 1070

HSP 3 Score: 99.3673 bits (246), Expect = 7.423e-21
Identity = 42/101 (41.58%), Postives = 69/101 (68.32%), Query Frame = 1 
Query: 1513 SKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            ++T    S + + SR+  ++E  + +G G FGVVF A+   D   YAVKR+ V  +D+AR+++L+E +A A  +HPGI+RY+ AW E PP+G+QE++D+ +
Sbjct:  585 NRTISRSSLEGFTSRFANEFEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLREARALAMFDHPGIIRYFYAWEERPPKGFQEKEDENL 685
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Match: Y38E10A.8 (pep chromosome:WBcel235:II:12607200:12608788:1 gene:WBGene00012586.1 transcript:Y38E10A.8.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y38E10A.8)

HSP 1 Score: 86.6557 bits (213), Expect = 2.713e-18
Identity = 53/149 (35.57%), Postives = 85/149 (57.05%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILF--DNQ-NHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMV 2550
            ++YI M L    +LKDW++  +T+  +RP    +     Q+  A+ +LHSN  +HRDLKP N+ F  D+Q   ++I DFGL T  +           +  +G     Q+ T+  GT  YM+PEQ +   +Y++KVD+F+LG+I  EL++
Sbjct:   93 HMYICMELCEQNTLKDWIKGNRTA-RSRPWM-LMKDWIKQLACALDHLHSNNFIHRDLKPENVFFARDSQFKKLKIGDFGLTTRAIEGLKDWKQRTQSQEAG-----QNHTAGAGTPSYMAPEQIR--NQYNEKVDIFALGLIAAELII 232
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Match: gcn-2 (Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [Source:UniProtKB/Swiss-Prot;Acc:D0Z5N4])

HSP 1 Score: 84.7297 bits (208), Expect = 2.560e-16
Identity = 67/239 (28.03%), Postives = 110/239 (46.03%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLAT-SMMRSK-------PPPSADVSAL--PSG--SHGDSQSLTSNVGTELYMSPE----QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFND 2781
            L I M      +L+ ++ E     A  PT   +  IF++++  + Y+H   ++HRD+KP NI   +QN ++I DFGLAT   M SK          S  + A+  P+G  S G     T ++GT+LYM+PE    +      Y  K+D++S G++  E+   PL   M+R   L   R              +++            +   +   VE   ++L  +PD+RPT + + ND
Sbjct:  778 LCIQMEYCDRATLRQYIDENHCFNA--PTE--VWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLR-------------DDIKIPSDFGAGLAAPMAGLARRTVE---KMLQRNPDERPTADDLLND 996

HSP 2 Score: 67.0106 bits (162), Expect = 6.575e-11
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 1 
Query: 1549 ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRY-SDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            + R   D   IR LG+G FG V   R+++D  +YA+KR+ +   SD+   K+ +E K FA L HP +VRYY AW E
Sbjct:  484 DGRMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAE 559
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Match: gcn-2 (Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [Source:UniProtKB/Swiss-Prot;Acc:D0Z5N4])

HSP 1 Score: 84.7297 bits (208), Expect = 2.560e-16
Identity = 67/239 (28.03%), Postives = 110/239 (46.03%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLAT-SMMRSK-------PPPSADVSAL--PSG--SHGDSQSLTSNVGTELYMSPE----QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFND 2781
            L I M      +L+ ++ E     A  PT   +  IF++++  + Y+H   ++HRD+KP NI   +QN ++I DFGLAT   M SK          S  + A+  P+G  S G     T ++GT+LYM+PE    +      Y  K+D++S G++  E+   PL   M+R   L   R              +++            +   +   VE   ++L  +PD+RPT + + ND
Sbjct:  778 LCIQMEYCDRATLRQYIDENHCFNA--PTE--VWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLR-------------DDIKIPSDFGAGLAAPMAGLARRTVE---KMLQRNPDERPTADDLLND 996

HSP 2 Score: 67.0106 bits (162), Expect = 6.575e-11
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 1 
Query: 1549 ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRY-SDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            + R   D   IR LG+G FG V   R+++D  +YA+KR+ +   SD+   K+ +E K FA L HP +VRYY AW E
Sbjct:  484 DGRMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAE 559
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Match: gcn-2 (Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [Source:UniProtKB/Swiss-Prot;Acc:D0Z5N4])

HSP 1 Score: 84.7297 bits (208), Expect = 2.560e-16
Identity = 67/239 (28.03%), Postives = 110/239 (46.03%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLAT-SMMRSK-------PPPSADVSAL--PSG--SHGDSQSLTSNVGTELYMSPE----QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFND 2781
            L I M      +L+ ++ E     A  PT   +  IF++++  + Y+H   ++HRD+KP NI   +QN ++I DFGLAT   M SK          S  + A+  P+G  S G     T ++GT+LYM+PE    +      Y  K+D++S G++  E+   PL   M+R   L   R              +++            +   +   VE   ++L  +PD+RPT + + ND
Sbjct:  778 LCIQMEYCDRATLRQYIDENHCFNA--PTE--VWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLR-------------DDIKIPSDFGAGLAAPMAGLARRTVE---KMLQRNPDERPTADDLLND 996

HSP 2 Score: 67.0106 bits (162), Expect = 6.575e-11
Identity = 33/76 (43.42%), Postives = 46/76 (60.53%), Query Frame = 1 
Query: 1549 ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRY-SDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            + R   D   IR LG+G FG V   R+++D  +YA+KR+ +   SD+   K+ +E K FA L HP +VRYY AW E
Sbjct:  484 DGRMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAE 559
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0330027)

HSP 1 Score: 133.265 bits (334), Expect = 3.047e-31
Identity = 89/225 (39.56%), Postives = 115/225 (51.11%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQI 2772
            +YLYI M L    SL+DWL++       R  TR   +  IF QIVDAV Y+H  GL+HRDLKPSNI F     I+I DFGL T M  + +      D S LPS +       T  VGT LYMSPE Q  G  YD KVD++SLG+IF EL V  ST MER   L   R  Q+      ++P+                      Q +   ++L+  P++RP  +Q+
Sbjct:  864 VYLYIQMQLCRKESLRDWLRD------NRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARH-----TQQVGTHLYMSPE-QLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ----------------------QYDLLQQMLSAQPEQRPQTKQL 1054

HSP 2 Score: 109.383 bits (272), Expect = 8.457e-24
Identity = 42/94 (44.68%), Postives = 69/94 (73.40%), Query Frame = 1 
Query: 1534 STDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            S +HY SR+ +D+E ++CLG+G FGVVFEA++++D+  YA+KR+ +   + +R ++L+E +  A  EH  IVRY+ +W E PP GWQE +D+++
Sbjct:  567 SGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKL 660

HSP 3 Score: 108.227 bits (269), Expect = 1.938e-23
Identity = 88/325 (27.08%), Postives = 153/325 (47.08%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGIN-AENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSS----------FPRTKDTC---------------------DLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGE-GGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVD-NGLVRQLALFAGDSHGRIEQIQDEFGCPRR----RSLFLGAYQGHMYVQ 1041
            +L IS++DG L  ++ A++G++ W++   P  L+S S+ +LE   + +  R+IPSL G +Y  + DGD   +  +PITA+ L SS+ + S D ++ GGK+ R +G +  TG++ Y C  +GC   +            P  +D                       D++I RR +  VRAV+   G+E+WNFSVGQ ++  +        P  E   AV++    +V              V  G I A  K     +LWK + +  +   W  + +  ++ + LF+  +    +Q +++   P       S++LG Y   +Y+Q
Sbjct:   11 LLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIY--KFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVV--------------VPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSS-AQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQ 316
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0078770)

HSP 1 Score: 133.265 bits (334), Expect = 3.671e-31
Identity = 89/225 (39.56%), Postives = 115/225 (51.11%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQI 2772
            +YLYI M L    SL+DWL++       R  TR   +  IF QIVDAV Y+H  GL+HRDLKPSNI F     I+I DFGL T M  + +      D S LPS +       T  VGT LYMSPE Q  G  YD KVD++SLG+IF EL V  ST MER   L   R  Q+      ++P+                      Q +   ++L+  P++RP  +Q+
Sbjct:  927 VYLYIQMQLCRKESLRDWLRD------NRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARH-----TQQVGTHLYMSPE-QLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ----------------------QYDLLQQMLSAQPEQRPQTKQL 1117

HSP 2 Score: 110.153 bits (274), Expect = 4.044e-24
Identity = 89/326 (27.30%), Postives = 155/326 (47.55%), Query Frame = 1 
Query:  184 RILLISSVDGNLCGIN-AENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGC--------------------EQDSSFPRTKDTC-----------DLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGE-GGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVD-NGLVRQLALFAGDSHGRIEQIQDEFGCPRR----RSLFLGAYQGHMYVQ 1041
            R+L IS++DG L  ++ A++G++ W++   P  L+S S+ +LE   + +  R+IPSL G +Y  + DGD   +  +PITA+ L SS+ + S D ++ GGK+ R +G +  TG++ Y C  +GC                    +Q     + +D             D++I RR +  VRAV+   G+E+WNFSVGQ ++  +        P  E   AV++    +V              V  G I A  K     +LWK + +  +   W  + +  ++ + LF+  +    +Q +++   P       S++LG Y   +Y+Q
Sbjct:   73 RLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIY--KFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVV--------------VPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSS-AQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQ 379

HSP 3 Score: 109.383 bits (272), Expect = 8.008e-24
Identity = 42/94 (44.68%), Postives = 69/94 (73.40%), Query Frame = 1 
Query: 1534 STDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            S +HY SR+ +D+E ++CLG+G FGVVFEA++++D+  YA+KR+ +   + +R ++L+E +  A  EH  IVRY+ +W E PP GWQE +D+++
Sbjct:  630 SGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKL 723
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Match: PEK (gene:FBgn0037327 transcript:FBtr0330026)

HSP 1 Score: 132.88 bits (333), Expect = 3.986e-31
Identity = 89/225 (39.56%), Postives = 115/225 (51.11%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQI 2772
            +YLYI M L    SL+DWL++       R  TR   +  IF QIVDAV Y+H  GL+HRDLKPSNI F     I+I DFGL T M  + +      D S LPS +       T  VGT LYMSPE Q  G  YD KVD++SLG+IF EL V  ST MER   L   R  Q+      ++P+                      Q +   ++L+  P++RP  +Q+
Sbjct:  875 VYLYIQMQLCRKESLRDWLRD------NRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARH-----TQQVGTHLYMSPE-QLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ----------------------QYDLLQQMLSAQPEQRPQTKQL 1065

HSP 2 Score: 110.923 bits (276), Expect = 2.324e-24
Identity = 89/331 (26.89%), Postives = 157/331 (47.43%), Query Frame = 1 
Query:  169 KIFFIRILLISSVDGNLCGIN-AENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSS----------FPRTKDTC---------------------DLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGE-GGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVD-NGLVRQLALFAGDSHGRIEQIQDEFGCPRR----RSLFLGAYQGHMYVQ 1041
            ++  +R+L IS++DG L  ++ A++G++ W++   P  L+S S+ +LE   + +  R+IPSL G +Y  + DGD   +  +PITA+ L SS+ + S D ++ GGK+ R +G +  TG++ Y C  +GC   +            P  +D                       D++I RR +  VRAV+   G+E+WNFSVGQ ++  +        P  E   AV++    +V              V  G I A  K     +LWK + +  +   W  + +  ++ + LF+  +    +Q +++   P       S++LG Y   +Y+Q
Sbjct:   16 RLSSMRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIY--KFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVV--------------VPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSS-AQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQ 327

HSP 3 Score: 109.383 bits (272), Expect = 8.094e-24
Identity = 42/94 (44.68%), Postives = 69/94 (73.40%), Query Frame = 1 
Query: 1534 STDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            S +HY SR+ +D+E ++CLG+G FGVVFEA++++D+  YA+KR+ +   + +R ++L+E +  A  EH  IVRY+ +W E PP GWQE +D+++
Sbjct:  578 SGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKL 671
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Match: Gcn2 (gene:FBgn0019990 transcript:FBtr0334551)

HSP 1 Score: 93.9745 bits (232), Expect = 4.948e-19
Identity = 67/232 (28.88%), Postives = 117/232 (50.43%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTR--YDQKVDVFSLGIIFIEL-MVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVV 2802
            +YI M      +L+  + +   +   R     L  +F +I + +A++H  G++HRDLKP NI  D+ + I+I DFGLAT+   +     A  + +   +  +  + T  VGT LY++PE     ++  Y+QKVD+++LGII  E+   P  T MERA  +   R +     + D+  ++ ++ +                 V+    LLN DP +RPT E++    +++D+V
Sbjct:  694 MYIQMEFCEKCTLRTAIDDNLFNDTDR-----LWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSIN--IPDAMLKDPKYEKT----------------VKMLQWLLNHDPAQRPTAEEL----LISDLV 898

HSP 2 Score: 62.7734 bits (151), Expect = 1.811e-9
Identity = 32/91 (35.16%), Postives = 52/91 (57.14%), Query Frame = 1 
Query: 1549 ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRV-RYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMG 1818
            +SR  T++E +  LGKGAFG V + R+ +D   YA+KR+ +   S +   K+ +EV+  + L H  +VRY+ +W E   +      DK +G
Sbjct:  516 QSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLG 606
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Match: Gcn2 (gene:FBgn0019990 transcript:FBtr0085787)

HSP 1 Score: 93.9745 bits (232), Expect = 4.948e-19
Identity = 67/232 (28.88%), Postives = 117/232 (50.43%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTR--YDQKVDVFSLGIIFIEL-MVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVV 2802
            +YI M      +L+  + +   +   R     L  +F +I + +A++H  G++HRDLKP NI  D+ + I+I DFGLAT+   +     A  + +   +  +  + T  VGT LY++PE     ++  Y+QKVD+++LGII  E+   P  T MERA  +   R +     + D+  ++ ++ +                 V+    LLN DP +RPT E++    +++D+V
Sbjct:  694 MYIQMEFCEKCTLRTAIDDNLFNDTDR-----LWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSIN--IPDAMLKDPKYEKT----------------VKMLQWLLNHDPAQRPTAEEL----LISDLV 898

HSP 2 Score: 62.7734 bits (151), Expect = 1.811e-9
Identity = 32/91 (35.16%), Postives = 52/91 (57.14%), Query Frame = 1 
Query: 1549 ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRV-RYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMG 1818
            +SR  T++E +  LGKGAFG V + R+ +D   YA+KR+ +   S +   K+ +EV+  + L H  +VRY+ +W E   +      DK +G
Sbjct:  516 QSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLG 606
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Match: eif2ak3 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:ZFIN;Acc:ZDB-GENE-050414-2])

HSP 1 Score: 137.887 bits (346), Expect = 1.709e-32
Identity = 77/168 (45.83%), Postives = 103/168 (61.31%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPS-ADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            +YLYI M L    +LKDW+  Q+  P  R  T+CL  IF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +     + ++ +P  +       T  VGT+LYMSPE Q  G  Y  KVD++SLG+I  EL+ P  T MER   LT+ R +QF
Sbjct:  870 VYLYIQMQLCRKENLKDWMA-QRCLPELREHTQCL-DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARH-----TGQVGTKLYMSPE-QLSGNSYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQF 1029

HSP 2 Score: 125.176 bits (313), Expect = 1.487e-28
Identity = 54/89 (60.67%), Postives = 70/89 (78.65%), Query Frame = 1 
Query: 1543 HYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
             Y SRY TD+E ++CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGI+RY+ AW E PP+GWQE  DK
Sbjct:  603 EYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAWQESPPQGWQEDMDK 691

HSP 3 Score: 108.612 bits (270), Expect = 1.908e-23
Identity = 86/322 (26.71%), Postives = 154/322 (47.83%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWN--IKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYP------QSPLGEGGAVINSGCVLV----QDSRDPGNVKYSFNVENGEIEA---IIK-------------PPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHG--------RIEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +++IS++DG +  ++  N G+  W+  + +  LVS SLSK E   + K F  IPSL+G L+  + + D   + A+  + ++L  S++++  D++LVGGK    +G   ++G++KY C   GC +        +  D+L+ +R    VRAV    G EKWNFSVG  ++  + +          ++P GE    +      V     D++   + K   N  + ++E    +IK              P  +++W+ Q    ++  WLV  G V  ++LF   S+           + I +E       S++LG +QG +Y+Q
Sbjct:  101 LVIISTLDGRIAALDPLNQGRKQWDLDVGSGCLVSSSLSKPEIFGN-KMF--IPSLDGALF--QWNRDRESMEAVSFSVESLLDSSYRIGEDTVLVGGKSLTTYGLGAYSGKLKYICSAVGCSRWGD--EEGEPEDVLLLQRTQKTVRAVRPRNGFEKWNFSVGNFELKFVPEIQSKLNFLEGEAPSGETWREVRREAQRVIQEETDAQTKNHAKMHPNSAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQFCTPIASAWLVGGGKVTPISLFDDTSYNSQTETETQEDDDIMEEARGATESSVYLGMFQGQLYLQ 415
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Match: BX072573.1 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:NCBI gene;Acc:559564])

HSP 1 Score: 137.502 bits (345), Expect = 1.831e-32
Identity = 77/168 (45.83%), Postives = 103/168 (61.31%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPS-ADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            +YLYI M L    +LKDW+  Q+  P  R  T+CL  IF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +     + ++ +P  +       T  VGT+LYMSPE Q  G  Y  KVD++SLG+I  EL+ P  T MER   LT+ R +QF
Sbjct:  870 VYLYIQMQLCRKENLKDWMA-QRCLPELREHTQCL-DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARH-----TGQVGTKLYMSPE-QLSGNSYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQF 1029

HSP 2 Score: 125.176 bits (313), Expect = 1.499e-28
Identity = 54/89 (60.67%), Postives = 70/89 (78.65%), Query Frame = 1 
Query: 1543 HYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
             Y SRY TD+E ++CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGI+RY+ AW E PP+GWQE  DK
Sbjct:  603 EYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAWQESPPQGWQEDMDK 691

HSP 3 Score: 108.612 bits (270), Expect = 1.892e-23
Identity = 86/322 (26.71%), Postives = 154/322 (47.83%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWN--IKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYP------QSPLGEGGAVINSGCVLV----QDSRDPGNVKYSFNVENGEIEA---IIK-------------PPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHG--------RIEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +++IS++DG +  ++  N G+  W+  + +  LVS SLSK E   + K F  IPSL+G L+  + + D   + A+  + ++L  S++++  D++LVGGK    +G   ++G++KY C   GC +        +  D+L+ +R    VRAV    G EKWNFSVG  ++  + +          ++P GE    +      V     D++   + K   N  + ++E    +IK              P  +++W+ Q    ++  WLV  G V  ++LF   S+           + I +E       S++LG +QG +Y+Q
Sbjct:  101 LVIISTLDGRIAALDPLNQGRKQWDLDVGSGCLVSSSLSKPEIFGN-KMF--IPSLDGALF--QWNRDRESMEAVSFSVESLLDSSYRIGEDTVLVGGKSLTTYGLGAYSGKLKYICSAVGCSRWGD--EEGEPEDVLLLQRTQKTVRAVRPRNGFEKWNFSVGNFELKFVPEVQSKLNFLEGEAPSGETWREVRREAQRVIQEETDAQTKNHAKMHPNSAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQFCTPIASAWLVGGGKVTPISLFDDTSYNSQTETETQEDDDIMEEARGATESSVYLGMFQGQLYLQ 415
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268])

HSP 1 Score: 122.865 bits (307), Expect = 2.564e-28
Identity = 80/244 (32.79%), Postives = 118/244 (48.36%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQT----------SPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATSMM----RSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILA 2793
            H+ LYI M L   RSLKDW+QE+ +           P         L I  +I++ V Y+HS G+MHRDLKP NI L  N+ H++I DFGLA   +      K P S+     P  +H      TS VGT +Y +PEQ + G+RYD K D++S+G+I  EL  P  T MER   L + R+ +    ++ ++P   ++ +                       L + DP  RP+  Q+    + +
Sbjct:  365 HLMLYIQMQL-CERSLKDWIQERNSRTTEGLLISGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLLGNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATH------TSGVGTFVYAAPEQLE-GSRYDSKSDMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKL----------------------LTSSDPSMRPSAPQLLQSDLFS 578

HSP 2 Score: 68.9366 bits (167), Expect = 2.003e-11
Identity = 31/75 (41.33%), Postives = 50/75 (66.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRV-RYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E I  LGKG++G VF   +++D   YAVK++ + + + +   K+L+EVK  + L+HP IV Y+ AW E
Sbjct:  140 SRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIKKVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWME 214
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268])

HSP 1 Score: 122.479 bits (306), Expect = 2.752e-28
Identity = 80/244 (32.79%), Postives = 118/244 (48.36%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQT----------SPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATSMM----RSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILA 2793
            H+ LYI M L   RSLKDW+QE+ +           P         L I  +I++ V Y+HS G+MHRDLKP NI L  N+ H++I DFGLA   +      K P S+     P  +H      TS VGT +Y +PEQ + G+RYD K D++S+G+I  EL  P  T MER   L + R+ +    ++ ++P   ++ +                       L + DP  RP+  Q+    + +
Sbjct:  365 HLMLYIQMQL-CERSLKDWIQERNSRTTEGLLMSGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLLGNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATH------TSGVGTFVYAAPEQLE-GSRYDSKSDMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKL----------------------LTSSDPSMRPSAPQLLQSDLFS 578

HSP 2 Score: 68.9366 bits (167), Expect = 1.903e-11
Identity = 31/75 (41.33%), Postives = 50/75 (66.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRV-RYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E I  LGKG++G VF   +++D   YAVK++ + + + +   K+L+EVK  + L+HP IV Y+ AW E
Sbjct:  140 SRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIKKVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWME 214
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268])

HSP 1 Score: 121.709 bits (304), Expect = 7.560e-28
Identity = 79/244 (32.38%), Postives = 118/244 (48.36%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQT----------SPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATSMM----RSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILA 2793
            H+ LYI M L   RSLKDW+QE+ +           P         L I  +I++ V Y+HS G+MHRDLKP NI L  N+ H++I DFGLA   +      K P S+     P  +H      TS VGT +Y +PEQ + G+RYD K +++S+G+I  EL  P  T MER   L + R+ +    ++ ++P   ++ +                       L + DP  RP+  Q+    + +
Sbjct:  412 HLMLYIQMQL-CERSLKDWIQERNSRTTEGLLMSGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKPRNIFLLGNECHVKIGDFGLACQNIIMDEHEKLPSSSQAGVNPDATH------TSGVGTFVYAAPEQLE-GSRYDSKANMYSIGVIAFELFQPFGTEMERVHTLGELRQGKIPNTLSTNWPILAKYIKL----------------------LTSSDPSMRPSAPQLLQSDLFS 625

HSP 2 Score: 68.9366 bits (167), Expect = 2.232e-11
Identity = 31/75 (41.33%), Postives = 50/75 (66.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRV-RYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E I  LGKG++G VF   +++D   YAVK++ + + + +   K+L+EVK  + L+HP IV Y+ AW E
Sbjct:  187 SRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIKKVTRDDCMKVLREVKVLSSLQHPNIVGYHTAWME 261
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297])

HSP 1 Score: 145.976 bits (367), Expect = 4.679e-35
Identity = 89/232 (38.36%), Postives = 127/232 (54.74%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVD 2805
            +YLYI M L    +LKDW+  + T    RP T  L H+F QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +    A ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  VLT+ R ++F    T+ +  E                            +++ +P++RP  E+I  +P+  D +D
Sbjct:  687 VYLYIQMQLCRKENLKDWMSARCTL-EERPQTESL-HVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARH-----TGQVGTKLYMSPE-QIFGQSYSHKVDIFSLGLILFELLYPFSTQMERVRVLTELRDLKFPQLFTERYSTEQN----------------------MVLHMISHNPNERPEAEEIIENPLF-DSID 886

HSP 2 Score: 127.872 bits (320), Expect = 2.448e-29
Identity = 58/101 (57.43%), Postives = 74/101 (73.27%), Query Frame = 1 
Query: 1507 DESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            D    F +  T  Y SRY TD+E I+CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  380 DLKDNFSDYQTFGYVSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQEKMDE 480

HSP 3 Score: 55.8398 bits (133), Expect = 3.720e-7
Identity = 52/193 (26.94%), Postives = 83/193 (43.01%), Query Frame = 1 
Query:  511 EVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGG-----AVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVL----WKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR-------IEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +VKY C   GC + +     +D  D+L+  R    VRAV    G EKWNFSVG  ++  +  D  P     EG      +   S  +   D ++ G    +  V   + + +    F+R L    W+ Q    ++  WLV NG V  ++LF   S+          E + +        S +LG ++G +Y+Q
Sbjct:   22 KVKYICSAMGCRRWNEDESEQD--DILLLHRKQKTVRAVGPRSGSEKWNFSVGHFELRYI-PDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAIKVSVADWKVM---AFNRKLGHLEWEHQFCTPIASAWLVRNGKVVPISLFDDTSYTSDDEIFEDEEDLVEAARGATESSFYLGMFRGQLYLQ 208
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297])

HSP 1 Score: 145.976 bits (367), Expect = 4.907e-35
Identity = 89/232 (38.36%), Postives = 127/232 (54.74%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVD 2805
            +YLYI M L    +LKDW+  + T    RP T  L H+F QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +    A ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  VLT+ R ++F    T+ +  E                            +++ +P++RP  E+I  +P+  D +D
Sbjct:  655 VYLYIQMQLCRKENLKDWMSARCTL-EERPQTESL-HVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARH-----TGQVGTKLYMSPE-QIFGQSYSHKVDIFSLGLILFELLYPFSTQMERVRVLTELRDLKFPQLFTERYSTE----------------------QNMVLHMISHNPNERPEAEEIIENPLF-DSID 854

HSP 2 Score: 122.094 bits (305), Expect = 1.187e-27
Identity = 53/85 (62.35%), Postives = 68/85 (80.00%), Query Frame = 1 
Query: 1555 RYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            RY TD+E I+CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  389 RYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQEKMDE 473

HSP 3 Score: 55.8398 bits (133), Expect = 3.688e-7
Identity = 52/193 (26.94%), Postives = 83/193 (43.01%), Query Frame = 1 
Query:  511 EVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGG-----AVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVL----WKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR-------IEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +VKY C   GC + +     +D  D+L+  R    VRAV    G EKWNFSVG  ++  +  D  P     EG      +   S  +   D ++ G    +  V   + + +    F+R L    W+ Q    ++  WLV NG V  ++LF   S+          E + +        S +LG ++G +Y+Q
Sbjct:   22 KVKYICSAMGCRRWNEDESEQD--DILLLHRKQKTVRAVGPRSGSEKWNFSVGHFELRYI-PDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAIKVSVADWKVM---AFNRKLGHLEWEHQFCTPIASAWLVRNGKVVPISLFDDTSYTSDDEIFEDEEDLVEAARGATESSFYLGMFRGQLYLQ 208
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297])

HSP 1 Score: 145.976 bits (367), Expect = 4.950e-35
Identity = 89/232 (38.36%), Postives = 127/232 (54.74%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVD 2805
            +YLYI M L    +LKDW+  + T    RP T  L H+F QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +    A ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  VLT+ R ++F    T+ +  E                            +++ +P++RP  E+I  +P+  D +D
Sbjct:  655 VYLYIQMQLCRKENLKDWMSARCTL-EERPQTESL-HVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARH-----TGQVGTKLYMSPE-QIFGQSYSHKVDIFSLGLILFELLYPFSTQMERVRVLTELRDLKFPQLFTERYSTEQN----------------------MVLHMISHNPNERPEAEEIIENPLF-DSID 854

HSP 2 Score: 127.102 bits (318), Expect = 3.214e-29
Identity = 58/101 (57.43%), Postives = 74/101 (73.27%), Query Frame = 1 
Query: 1507 DESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            D    F +  T  Y SRY TD+E I+CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  385 DLKDNFSDYQTFGYVSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQEKMDE 485

HSP 3 Score: 55.8398 bits (133), Expect = 4.085e-7
Identity = 52/193 (26.94%), Postives = 83/193 (43.01%), Query Frame = 1 
Query:  511 EVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGG-----AVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVL----WKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR-------IEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +VKY C   GC + +     +D  D+L+  R    VRAV    G EKWNFSVG  ++  +  D  P     EG      +   S  +   D ++ G    +  V   + + +    F+R L    W+ Q    ++  WLV NG V  ++LF   S+          E + +        S +LG ++G +Y+Q
Sbjct:   25 KVKYICSAMGCRRWNEDESEQD--DILLLHRKQKTVRAVGPRSGSEKWNFSVGHFELRYI-PDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAIKVSVADWKVMA---FNRKLGHLEWEHQFCTPIASAWLVRNGKVVPISLFDDTSYTSDDEIFEDEEDLVEAARGATESSFYLGMFRGQLYLQ 211
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297])

HSP 1 Score: 145.976 bits (367), Expect = 5.168e-35
Identity = 89/232 (38.36%), Postives = 127/232 (54.74%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVD 2805
            +YLYI M L    +LKDW+  + T    RP T  L H+F QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +    A ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  VLT+ R ++F    T+ +  E                            +++ +P++RP  E+I  +P+  D +D
Sbjct:  668 VYLYIQMQLCRKENLKDWMSARCTL-EERPQTESL-HVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARH-----TGQVGTKLYMSPE-QIFGQSYSHKVDIFSLGLILFELLYPFSTQMERVRVLTELRDLKFPQLFTERYSTEQN----------------------MVLHMISHNPNERPEAEEIIENPLF-DSID 867

HSP 2 Score: 127.102 bits (318), Expect = 3.811e-29
Identity = 58/101 (57.43%), Postives = 74/101 (73.27%), Query Frame = 1 
Query: 1507 DESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            D    F +  T  Y SRY TD+E I+CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  361 DLKDNFSDYQTFGYVSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQEKMDE 461

HSP 3 Score: 57.3806 bits (137), Expect = 1.417e-7
Identity = 53/193 (27.46%), Postives = 83/193 (43.01%), Query Frame = 1 
Query:  511 EVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGG-----AVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVL----WKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR-------IEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            EVKY C   GC + +     +D  D+L+  R    VRAV    G EKWNFSVG  ++  +  D  P     EG      +   S  +   D ++ G    +  V   + + +    F+R L    W+ Q    ++  WLV NG V  ++LF   S+          E + +        S +LG ++G +Y+Q
Sbjct:    3 EVKYICSAMGCRRWNEDESEQD--DILLLHRKQKTVRAVGPRSGSEKWNFSVGHFELRYI-PDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAIKVSVADWKVMA---FNRKLGHLEWEHQFCTPIASAWLVRNGKVVPISLFDDTSYTSDDEIFEDEEDLVEAARGATESSFYLGMFRGQLYLQ 189
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Match: cpt1al (carnitine palmitoyltransferase 1A (liver) like [Source:Xenbase;Acc:XB-GENE-5770297])

HSP 1 Score: 145.976 bits (367), Expect = 5.346e-35
Identity = 89/232 (38.36%), Postives = 127/232 (54.74%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVD 2805
            +YLYI M L    +LKDW+  + T    RP T  L H+F QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +    A ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  VLT+ R ++F    T+ +  E                            +++ +P++RP  E+I  +P+  D +D
Sbjct:  689 VYLYIQMQLCRKENLKDWMSARCTL-EERPQTESL-HVFLQIAEAVQFLHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEE-DEEAVLTPMPAYARH-----TGQVGTKLYMSPE-QIFGQSYSHKVDIFSLGLILFELLYPFSTQMERVRVLTELRDLKFPQLFTERYSTEQN----------------------MVLHMISHNPNERPEAEEIIENPLF-DSID 888

HSP 2 Score: 127.487 bits (319), Expect = 3.210e-29
Identity = 58/101 (57.43%), Postives = 74/101 (73.27%), Query Frame = 1 
Query: 1507 DESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            D    F +  T  Y SRY TD+E I+CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  382 DLKDNFSDYQTFGYVSRYLTDFEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPELWQEKMDE 482

HSP 3 Score: 55.4546 bits (132), Expect = 4.540e-7
Identity = 52/193 (26.94%), Postives = 83/193 (43.01%), Query Frame = 1 
Query:  511 EVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGG-----AVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVL----WKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR-------IEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +VKY C   GC + +     +D  D+L+  R    VRAV    G EKWNFSVG  ++  +  D  P     EG      +   S  +   D ++ G    +  V   + + +    F+R L    W+ Q    ++  WLV NG V  ++LF   S+          E + +        S +LG ++G +Y+Q
Sbjct:   22 KVKYICSAMGCRRWNEDESEQD--DILLLHRKQKTVRAVGPRSGSEKWNFSVGHFELRYI-PDIEPGVGFIEGQLEPSYSTDESRIISDGDDQEVGTNDLAIKVSVADWKVM---AFNRKLGHLEWEHQFCTPIASAWLVRNGKVVPISLFDDTSYTSDDEIFEDEEDLVEAARGATESSFYLGMFRGQLYLQ 208
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Match: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3 [Source:MGI Symbol;Acc:MGI:1341830])

HSP 1 Score: 202.601 bits (514), Expect = 8.201e-53
Identity = 165/592 (27.87%), Postives = 281/592 (47.47%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL----DKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAI-IKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSH-------GRIEQIQDEFGCPRRRSLFLGAYQGHMYVQ---------------LEDGNGRSA--PRP------------RYVSLSGTDLTQTTLDISLSK-RHRVAKMTRHETTALQH----GFFRPPIK-DLIEPSDAWFIQHGKDEYYPPS---TEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            +++IS++DG +  ++AEN G+  W++        S S  +      K  +IPSL+G L+  + D D   + A+P T ++L  S+++   D +LVGGK    +G + ++G+++Y C   GC +       ++  D+L+ +R    VRAV    G EKWNFSVG  ++  +     +  + +S    GG   +S  +   + ++   +     V   + + +       R+ W+ Q    ++  WLV +G V  ++LF   S+       G  E I +        S++LG Y+G +Y+Q               LE  NG +A  P P            R   L G+D      D  LS  ++   + +    + LQ+    G++ P  K +  + S    ++     +Y  +    +P+++ +        I  C+V   F  I  R++ P Q +R   +            + +A +S +             ++ ++    Y SRY TD+E I+C+G+G FGVVFEA+++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE  D+
Sbjct:  101 LVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSLSKPEVFGNKM-IIPSLDGDLF--QWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKLRYICSALGCRR-WDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKPGGNKEDSKIISDVEEQEATMLDTVIKVSVADWKVMAFSRKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTASEEALGDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTSPKALESVNGENAIIPLPTIKWKPLIHSPSRTPVLVGSD----EFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTF--IVRRLFHP-QPHRQRKESETQCQTESKYDSVSADVSDN-------------SWNDMKYSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDE 668

HSP 2 Score: 146.362 bits (368), Expect = 4.396e-35
Identity = 88/231 (38.10%), Postives = 124/231 (53.68%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPS-GSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            +YLYI M L    +LKDW+  ++ S   R    CL HIF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +   +  ++ +P+  +H      T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  +LT  R ++F    T  +P+E    +                       +L+P P +RP    I  + I  ++
Sbjct:  880 VYLYIQMQLCRKENLKDWMN-RRCSLEDREHGVCL-HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV-LTPMPAYATH------TGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQD----------------------MLSPSPTERPEATDIIENAIFENL 1078
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427])

HSP 1 Score: 118.242 bits (295), Expect = 2.634e-26
Identity = 84/229 (36.68%), Postives = 114/229 (49.78%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGD-SQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +       R T+R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D  A       D S  LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  517 YLYIQMEYCEKSTLRDTIDQG----LFRDTSR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPDDFDDGEHTK-------------QKSVISWLLNHDPAKRPTAMELLKSELL 722

HSP 2 Score: 65.855 bits (159), Expect = 3.182e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  305 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIE 378
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427])

HSP 1 Score: 118.242 bits (295), Expect = 2.842e-26
Identity = 84/229 (36.68%), Postives = 114/229 (49.78%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGD-SQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +       R T+R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D  A       D S  LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  674 YLYIQMEYCEKSTLRDTIDQG----LFRDTSR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPDDFDDGEHTK-------------QKSVISWLLNHDPAKRPTAMELLKSELL 879

HSP 2 Score: 65.4698 bits (158), Expect = 3.830e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  462 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIE 535
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427])

HSP 1 Score: 118.242 bits (295), Expect = 2.850e-26
Identity = 84/229 (36.68%), Postives = 114/229 (49.78%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGD-SQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +       R T+R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D  A       D S  LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  683 YLYIQMEYCEKSTLRDTIDQG----LFRDTSR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPDDFDDGEHTK-------------QKSVISWLLNHDPAKRPTAMELLKSELL 888

HSP 2 Score: 65.4698 bits (158), Expect = 3.614e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  471 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIE 544
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Match: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427])

HSP 1 Score: 118.242 bits (295), Expect = 2.880e-26
Identity = 84/229 (36.68%), Postives = 114/229 (49.78%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGD-SQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +       R T+R L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT  +        D  A       D S  LT  VGT LY+SPE Q    + Y+QKVD+FSLGIIF E+   P+ T  ER  VL + R    +P  +  FP +                     Q      LLN DP KRPT  ++    +L
Sbjct:  717 YLYIQMEYCEKSTLRDTIDQG----LFRDTSR-LWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLR----DP-TSPKFPDDFDDGEHTK-------------QKSVISWLLNHDPAKRPTAMELLKSELL 922

HSP 2 Score: 65.4698 bits (158), Expect = 3.756e-10
Identity = 30/74 (40.54%), Postives = 45/74 (60.81%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++E ++ LGKGAFG V + ++++D   YAVKR+ +  +     ++  EV   + L H  IVRYY AW E
Sbjct:  505 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIE 578
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Match: sp|Q9Z1Z1|E2AK3_RAT (Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Rattus norvegicus OX=10116 GN=Eif2ak3 PE=1 SV=1)

HSP 1 Score: 207.223 bits (526), Expect = 1.636e-53
Identity = 173/591 (29.27%), Postives = 286/591 (48.39%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL----DKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQI----QDEFGCPR---RRSLFLGAYQGHMYVQ---------------LEDGNGRSA--PRP------------RYVSLSGTDLTQTTLDISLSK-RHRVAKMTRHETTALQH----GFFRPPIK-DLIEPSDAWFIQHGKDEYYPPS---TEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            +++IS++DG +  ++AEN G+  W++        S S  +      K  +IPSL+G L+  + D D   + A+P T ++L  S+++   D +LVGGK    +G + ++G+++Y C   GC +       ++  D+L+ +R    VRAV    G EKWNFSVG  ++  +     +  + +S    GG   +S  +   + +D   V    +V + ++ A  K    R+ W+ Q    ++  WLV +G V  ++LF   S+   E++    +D     R     S++LG Y+G +Y+Q               LE  NG SA  P P            R   L G+D      D  LS  ++   + +    + LQ+    G++ P  K +  + S    ++     +Y  +    +P+++ +        I  C+V   F  I  R++ P Q +R   +           Q    S   SV      A +   ++ ++    Y SRY TD+E I+C+G+G FGVVFEA+++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE  D+
Sbjct:  100 LVIISTLDGRIAALDAENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKM-IIPSLDGDLF--QWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKLRYICSALGCRR-WDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKLGGNKEDSKIISDVEEQDVDTV-IKVSVADWKVMAFSKKG-GRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTANEEVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTRPKALESVNGESAIIPLPTIKWKPLIHSPSRTPVLVGSD----EFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTF--IVRRLFHP-QPHRQRKESET--------QCQTESKYDSV-----SADNSDNSWNDIKHSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDE 664

HSP 2 Score: 147.902 bits (372), Expect = 9.779e-35
Identity = 88/231 (38.10%), Postives = 124/231 (53.68%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPS-GSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            +YLYI M L    +LKDW+  ++ S   R    CL HIF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +   +  ++ +P+  +H      T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER   LT  R ++F P  T  +P+E    +                       +L+P P +RP    I  + +  ++
Sbjct:  874 VYLYIQMQLCRKENLKDWMN-RRCSMEDREHRVCL-HIFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV-LTPMPAYATH------TGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPQEHMMVQD----------------------MLSPSPMERPEATDIIENAVFENL 1072
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Match: sp|Q9Z2B5|E2AK3_MOUSE (Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Mus musculus OX=10090 GN=Eif2ak3 PE=1 SV=1)

HSP 1 Score: 201.445 bits (511), Expect = 1.136e-51
Identity = 165/592 (27.87%), Postives = 281/592 (47.47%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL----DKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAI-IKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSH-------GRIEQIQDEFGCPRRRSLFLGAYQGHMYVQ---------------LEDGNGRSA--PRP------------RYVSLSGTDLTQTTLDISLSK-RHRVAKMTRHETTALQH----GFFRPPIK-DLIEPSDAWFIQHGKDEYYPPS---TEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            +++IS++DG +  ++AEN G+  W++        S S  +      K  +IPSL+G L+  + D D   + A+P T ++L  S+++   D +LVGGK    +G + ++G+++Y C   GC +       ++  D+L+ +R    VRAV    G EKWNFSVG  ++  +     +  + +S    GG   +S  +   + ++   +     V   + + +       R+ W+ Q    ++  WLV +G V  ++LF   S+       G  E I +        S++LG Y+G +Y+Q               LE  NG +A  P P            R   L G+D      D  LS  ++   + +    + LQ+    G++ P  K +  + S    ++     +Y  +    +P+++ +        I  C+V   F  I  R++ P Q +R   +            + +A +S +             ++ ++    Y SRY TD+E I+C+G+G FGVVFEA+++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE  D+
Sbjct:  101 LVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSLSKPEVFGNKM-IIPSLDGDLF--QWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLITYGLSAYSGKLRYICSALGCRR-WDSDEMEEEEDILLLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKPGGNKEDSKIISDVEEQEATMLDTVIKVSVADWKVMAFSRKGGRLEWEYQFCTPIASAWLVRDGKVIPISLFDDTSYTASEEALGDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTSPKALESVNGENAIIPLPTIKWKPLIHSPSRTPVLVGSD----EFDKCLSNDKYSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDSPHYSKNIRKKDPILLLHWWKEIFGTILLCIVATTF--IVRRLFHP-QPHRQRKESETQCQTESKYDSVSADVSDN-------------SWNDMKYSGYVSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDE 668

HSP 2 Score: 146.362 bits (368), Expect = 2.945e-34
Identity = 88/231 (38.10%), Postives = 124/231 (53.68%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPS-GSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            +YLYI M L    +LKDW+  ++ S   R    CL HIF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +   +  ++ +P+  +H      T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER  +LT  R ++F    T  +P+E    +                       +L+P P +RP    I  + I  ++
Sbjct:  880 VYLYIQMQLCRKENLKDWMN-RRCSLEDREHGVCL-HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV-LTPMPAYATH------TGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQD----------------------MLSPSPTERPEATDIIENAIFENL 1078
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Match: sp|Q9NZJ5|E2AK3_HUMAN (Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Homo sapiens OX=9606 GN=EIF2AK3 PE=1 SV=3)

HSP 1 Score: 146.747 bits (369), Expect = 2.091e-34
Identity = 88/230 (38.26%), Postives = 122/230 (53.04%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            +YLYI M L    +LKDW+  + T    R  + CL HIF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M + +   +  ++ +P+ +       T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P ST MER   LT  R ++F P  T  +P E    +                       +L+P P +RP    I  + +  D+
Sbjct:  882 VYLYIQMQLCRKENLKDWMNGRCTI-EERERSVCL-HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV-LTPMPAYARH-----TGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQD----------------------MLSPSPMERPEAINIIENAVFEDL 1080

HSP 2 Score: 129.028 bits (323), Expect = 7.573e-29
Identity = 69/160 (43.12%), Postives = 96/160 (60.00%), Query Frame = 1 
Query: 1330 IFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            I FC++   F  I  R++ P+   +    ++         Q  N   S S     G A D S  + ++    Y SRY TD+E I+CLG+G FGVVFEA+++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGIVRY+ AW E PPE WQE+ D+
Sbjct:  529 ILFCIIATTF--IVRRLFHPHPHRQRKESETQ-------CQTENKYDSVS-----GEANDSS--WNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDE 672

HSP 3 Score: 105.531 bits (262), Expect = 1.066e-21
Identity = 79/299 (26.42%), Postives = 146/299 (48.83%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL----DKDSYPQSPLGEGGAVINSGCVLVQDSRDPG--NVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGR----IEQIQDEFGCPR---RRSLFLGAYQGHMYVQ 1041
            +++IS++DG +  ++ EN G+  W++        S S  +      K  +IPSL+G L+  + D D   +  +P T ++L  S+++   D +LVGGK    +G + ++G+V+Y C   GC Q  S    ++  D+L+ +R    VRAV    G EKWNFSVG  ++  +     +  + +S          S  +   + ++    ++    +V + ++ A  K   H + W+ Q    ++  WL+ +G V  ++LF   S+      +E  +D     R     S++LG Y+G +Y+Q
Sbjct:  105 LVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKM-IIPSLDGALF--QWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEE-DILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGH-LEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQ 398
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Match: sp|Q9NIV1|E2AK3_DROME (Eukaryotic translation initiation factor 2-alpha kinase OS=Drosophila melanogaster OX=7227 GN=PEK PE=1 SV=2)

HSP 1 Score: 133.265 bits (334), Expect = 3.679e-30
Identity = 89/225 (39.56%), Postives = 115/225 (51.11%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQI 2772
            +YLYI M L    SL+DWL++       R  TR   +  IF QIVDAV Y+H  GL+HRDLKPSNI F     I+I DFGL T M  + +      D S LPS +       T  VGT LYMSPE Q  G  YD KVD++SLG+IF EL V  ST MER   L   R  Q+      ++P+                      Q +   ++L+  P++RP  +Q+
Sbjct:  927 VYLYIQMQLCRKESLRDWLRD------NRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARH-----TQQVGTHLYMSPE-QLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ----------------------QYDLLQQMLSAQPEQRPQTKQL 1117

HSP 2 Score: 110.153 bits (274), Expect = 4.054e-23
Identity = 89/326 (27.30%), Postives = 155/326 (47.55%), Query Frame = 1 
Query:  184 RILLISSVDGNLCGIN-AENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGC--------------------EQDSSFPRTKDTC-----------DLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGE-GGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVD-NGLVRQLALFAGDSHGRIEQIQDEFGCPRR----RSLFLGAYQGHMYVQ 1041
            R+L IS++DG L  ++ A++G++ W++   P  L+S S+ +LE   + +  R+IPSL G +Y  + DGD   +  +PITA+ L SS+ + S D ++ GGK+ R +G +  TG++ Y C  +GC                    +Q     + +D             D++I RR +  VRAV+   G+E+WNFSVGQ ++  +        P  E   AV++    +V              V  G I A  K     +LWK + +  +   W  + +  ++ + LF+  +    +Q +++   P       S++LG Y   +Y+Q
Sbjct:   73 RLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIY--KFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVV--------------VPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSS-AQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQ 379

HSP 3 Score: 109.383 bits (272), Expect = 8.028e-23
Identity = 42/94 (44.68%), Postives = 69/94 (73.40%), Query Frame = 1 
Query: 1534 STDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            S +HY SR+ +D+E ++CLG+G FGVVFEA++++D+  YA+KR+ +   + +R ++L+E +  A  EH  IVRY+ +W E PP GWQE +D+++
Sbjct:  630 SGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKL 723
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Match: sp|P15442|GCN2_YEAST (eIF-2-alpha kinase GCN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GCN2 PE=1 SV=3)

HSP 1 Score: 125.176 bits (313), Expect = 1.273e-27
Identity = 75/221 (33.94%), Postives = 116/221 (52.49%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFN 2778
            L+I M    +R+L D +  +  +       R    +F QI++A++Y+HS G++HRDLKP NI  D   +++I DFGLA ++ RS      D   LP    G S +LTS +GT +Y++ E       Y++K+D++SLGIIF E++ P STGMER  +L K R +  E      FP +    +               V+ +    L++ DP+KRP    + N
Sbjct:  784 LFIQMEYCENRTLYDLIHSENLNQQRDEYWR----LFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP----GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSVSIE------FPPDFDDNKMK-------------VEKKIIRLLIDHDPNKRPGARTLLN 977

HSP 2 Score: 74.7146 bits (182), Expect = 4.040e-12
Identity = 35/74 (47.30%), Postives = 49/74 (66.22%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +D+E I  LG+GAFG V +AR+ +D   YA+K  ++R+++E  S +L EV   A L H  +VRYY AW E
Sbjct:  593 SRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIK--KIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLE 664
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Match: G4VBQ0 (Protein kinase OS=Schistosoma mansoni OX=6183 GN=Smp_060940.1 PE=4 SV=1)

HSP 1 Score: 353.214 bits (905), Expect = 1.015e-101
Identity = 311/1072 (29.01%), Postives = 475/1072 (44.31%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLE--IDGDDN-----GLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKD----TCD-LLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKD-SYPQSPLGEGGAVIN-------SGCVLVQDS-RDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGL--VRQLALFAGDSHG--RIEQIQD--------------EFG-------------------CPRR-RSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDI-------------SLSKRHRVAKMTR------------HETTALQH----GFFRP---------PIKDL----IEPSD-----AWFIQHGKD-------------EYYPPSTE---PLVVKYGSFLFQKFIFFCLVVVIFHLIFT-RIYLPYQLYRXXXXXXXXXXXXVCLQAPNAS---------LSSSVP--CPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK-EMGLC-NLYXXXXXXXXXXXXXREISNQ-----------------DLTRCTATNSDWSKFSILAEGD-QDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMM----------------RSKPPPSADVSALPSGSHGDSQSLTSN------------------------------VGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVV 2802
            +L+ ++VDG+  G++ ++G+++W I  PPLVSQSLS L+ I   K + ++PSL+GQL+++E  + GD +      L+ALP++ D+LFSS F L+ DSLL GG++   F FNP  G+++Y C +DGC       +  +    T D  +I  R+++VVRAV    G+EKWN SV Q ++  L      P + + +   + N       +    V +S  D     +   ++   I A  K      +W    N+ +S+ W+    L  +R L+LF  D      IE++ +              E G                   CP R R ++LG+  G +YVQ ED  G   P P  ++LS +  T +   +             S S   ++ K T+             + TAL      G F+P         P K L    IE SD       F+ +  D              + P   E    L     ++  Q  +   ++    H I   +I    QL   + Q  +   +SV ++  ++S         LS S P      P+     T  N     + S ++TD+++IR LG+G FG VFE  +R+D   YA+KR+++  +D+ ++  L+EVKA A L+HPGIVRY++AW E PP GWQE  D+  +GL  +L       +   +    +SN                  D +      S  S +  L++    DSLI+FD              T       S     S    + +      ++Y  I M L S  SL+DWL      P +RP    L+ +F QIV+AVAYLH + LMHRDLKPSNILFD  N +++ DFGL TSM+                R +    + V+ + +  +G S+   +N                              VGT+LYMSPE Q++G  Y+ KVD+FSLG+IFIEL++  +T MER   LT+A+  +         P+E     P               + EF  +LL+ DP KRP    I    ++   V
Sbjct:   34 VLIANTVDGSFIGLDIKSGKLVWKIDGPPLVSQSLSDLQLITKTKSYSIVPSLDGQLFLMERKLTGDSDLLRGASLKALPLSIDSLFSSNFMLTEDSLLTGGREHSTFTFNPNNGKIRYNCTRDGCTSSDVDKKLVEEPLNTNDPTIIVYRVNNVVRAVSAPSGIEKWNLSVHQYELCLLTGGIPTPTTAVQKTSPICNVPLGTPHTHKKFVDESFVDMEEPDWDIGLDKHTITARTKGLQSEEIWSYNFNSRISKAWIYRRDLQNLRPLSLFMYDRVALLLIEKVNEFKKATAISNLESLKEKGLNLFNGKNTLSSSRKQKPDCPSRDRLIYLGSLNGQLYVQTED--GVDLPNPEMINLSKSLSTNSAESLNNRRFDLTGYYQASYSNSPKLKKYTQPFLLYDSVEETIEKATALGFPSSVGQFKPVLGFQPETIPEKALTSTDIEMSDTSGIPGQFLDNANDLLMLLLRASEIAVNHSPSGIENSRSLGFNLSTYFMQLLVLTGVIYFTAHWIMNVKINYDTQLKNYSFQSESCNLESVVVKTHSSSENLCDTLKCLSCSTPNYLTSNPSCQSLLTTANTQPPSFISSFETDFKYIRRLGRGGFGQVFEVENRLDGCRYAIKRIKMNDTDDDKNIFLREVKALATLDHPGIVRYHRAWKEYPPAGWQESHDELVLGLSDDLTSRSSDFTDCGNNENCLSNTLFSSNVDSRHSSVSLCVDKSSIGLNESHHSSYRKLSKACLDDSLIVFDHQNS----------TETLSLDGSSLTEQSIKDKSKNETKYTCYLY--IQMQLCSPISLRDWLVSHSI-PESRPPRVELICMFRQIVEAVAYLHDHSLMHRDLKPSNILFDLTNRLKLADFGLVTSMIDDKLNQSDSSYINCNKRGEQSSCSSVTTIVNDLNGQSEHNNNNAIIDRQLYPLKEISTAQQKRSVLTRRHTDHVGTDLYMSPE-QERGDNYNHKVDIFSLGLIFIELLIIFNTSMERIFTLTRAKHQK--------LPKEFIICNP--------------FETEFVLKLLDYDPVKRPDAPAILESALIKQSV 1067
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Match: A0A5N4AV15 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_05520 PE=4 SV=1)

HSP 1 Score: 268.47 bits (685), Expect = 7.131e-73
Identity = 234/844 (27.73%), Postives = 386/844 (45.73%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRA--LPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSK---RHRVAKMT-------RHETTALQ----------HGFFRPPIKDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYXXXXXXXXXXXXXREISNQDLTRCTATNSDWSKFSILAEGDQDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREV 2646
            ++ +S++DG    + +  G + W I   P  L++ ++ +LE   + +  R+IPSL G LY        NG+    LPI+AD+L +S+F+   D  + GG++ R +G    TG+  Y C   GC   + +  T+D  D++I  R +H VRAV+   G+E+WNF+VGQ ++                  +    C  V  +    N+  S  +  G + A        ++W+ + +  +   W  D   V  L LF+  +    ++  D        S+++G +   +Y+        S     ++   G D        SL+K   +   A +          ++TAL           +GF+    + L+  ++      G +   PP      +    +  +  +    ++ IF+++FT     Y+L R         + +V L AP             P+  +   F    T  Y + +D     I CLGKG FGVVF A+ + D+  YA+KR+ +   + A+ ++++EVKA A L+H  IVRYY AW E PP GWQ   D+   L + +    S S+ S      +    + C+     + +++        S I+F+ SA  P+       + RS             +N+ +  ++  ++Y  I M L   +SLK+WL    ++ + R  ++ L  IF QIV+AV Y+H   L+HRDLKPSNI F  +  I++ DFGL TS+         D S L        +S T+ VGT LYMSPE Q    +YD KVD++SLGII  EL+V  +T MER  VL+  R+ ++    T    +E+
Sbjct:   39 LIFVSTLDGAFSALTS-TGTLAWQIGTGPGSLLNSNIHQLELSNNGQWIRIIPSLSGSLYKF------NGITVDPLPISADSLLTSSFRYLDDLAVAGGREVRTYGVALHTGQTLYECSLGGCHNTTEY--TEDVLDVIIVERKTHTVRAVEPRTGVERWNFTVGQHNI-----------------KIPYLSC--VNTNMKVTNINISAVLPEGLLSASHMEKPTNIIWQYKFDTPIVAIWRWDGREVTPLNLFSSPAVMVSKKKADT------PSIYVGMHNKQLYIH----ESTSMKNILHLRQRGGDKDSVIESQSLAKIPWKPVPAVLEIDGIDNDTDDSTALSVLYGSEYVNGNGFYLYTDEKLVCGNN------GTNSTIPPKVSQETI--WDWWKEALVIIITLMFIFNMVFT-----YKLPR------FYKHDNVVLPAP-------------PSETDETAF----TSRYMTEFDP----IACLGKGGFGVVFHAKKKFDECEYAIKRITLPKRETAKDRMMREVKALAKLDHRNIVRYYNAWLESPPYGWQVEHDQR--LLSDFSSYNSTSAPSRLFSTFAKNVESHCSFETGFFDEYNRNESVGDGSSIVFENSANTPT-------SKRSKESTVSKYNQRRDSNSCTVCISPIYLY--IQMQLCCKQSLKEWL----STCSVRDRSQSLA-IFGQIVEAVEYVHFRHLIHRDLKPSNIFFSLEGQIKVGDFGLVTSIKEYDADDDDDYSKL-----SLKKSYTNAVGTHLYMSPE-QLNAQQYDSKVDIYSLGIILFELLVAFNTEMERVNVLSNVRQRKYPKEFTAKISKEL 782
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Match: A0A1Y1KD93 (Protein kinase domain-containing protein OS=Photinus pyralis OX=7054 PE=4 SV=1)

HSP 1 Score: 268.47 bits (685), Expect = 8.102e-73
Identity = 234/844 (27.73%), Postives = 386/844 (45.73%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVMWNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRA--LPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSK---RHRVAKMT-------RHETTALQ----------HGFFRPPIKDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYXXXXXXXXXXXXXREISNQDLTRCTATNSDWSKFSILAEGDQDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREV 2646
            ++ +S++DG    + +  G + W I   P  L++ ++ +LE   + +  R+IPSL G LY        NG+    LPI+AD+L +S+F+   D  + GG++ R +G    TG+  Y C   GC   + +  T+D  D++I  R +H VRAV+   G+E+WNF+VGQ ++                  +    C  V  +    N+  S  +  G + A        ++W+ + +  +   W  D   V  L LF+  +    ++  D        S+++G +   +Y+        S     ++   G D        SL+K   +   A +          ++TAL           +GF+    + L+  ++      G +   PP      +    +  +  +    ++ IF+++FT     Y+L R         + +V L AP             P+  +   F    T  Y + +D     I CLGKG FGVVF A+ + D+  YA+KR+ +   + A+ ++++EVKA A L+H  IVRYY AW E PP GWQ   D+   L + +    S S+ S      +    + C+     + +++        S I+F+ SA  P+       + RS             +N+ +  ++  ++Y  I M L   +SLK+WL    ++ + R  ++ L  IF QIV+AV Y+H   L+HRDLKPSNI F  +  I++ DFGL TS+         D S L        +S T+ VGT LYMSPE Q    +YD KVD++SLGII  EL+V  +T MER  VL+  R+ ++    T    +E+
Sbjct:   39 LIFVSTLDGAFSALTS-TGTLAWQIGTGPGSLLNSNIHQLELSNNGQWIRIIPSLSGSLYKF------NGITVDPLPISADSLLTSSFRYLDDLAVAGGREVRTYGVALHTGQTLYECSLGGCHNTTEY--TEDVLDVIIVERKTHTVRAVEPRTGVERWNFTVGQHNI-----------------KIPYLSC--VNTNMKVTNINISAVLPEGLLSASHMEKPTNIIWQYKFDTPIVAIWRWDGREVTPLNLFSSPAVMVSKKKADT------PSIYVGMHNKQLYIH----ESTSMKNILHLRQRGGDKDSVIESQSLAKIPWKPIPAVLEIDGIDNDTDDSTALSVLYGSEYVNGNGFYLYTDEKLVCGNN------GTNSTIPPKVSQETI--WDWWKEALVIIITLMFIFNMVFT-----YKLPR------FYKHDNVVLPAP-------------PSETDETAF----TSRYMTEFDP----IACLGKGGFGVVFHAKKKFDECEYAIKRITLPKRETAKDRMMREVKALAKLDHRNIVRYYNAWLESPPYGWQVEHDQR--LLSDFSSYNSTSAPSRLFSTFAKNVESHCSFETGFFDEYNRNESVGDGSSIVFENSANTPT-------SKRSKESTVSKYNQRRDSNSCTVCISPIYLY--IQMQLCCKQSLKEWL----STCSVRDRSQSLA-IFGQIVEAVEYVHFRHLIHRDLKPSNIFFSLEGQIKVGDFGLVTSIKEYDADDDDDYSKL-----SLKKSYTNAVGTHLYMSPE-QLNAQQYDSKVDIYSLGIILFELLVAFNTEMERVNVLSNVRQRKYPKEFTAKISKEL 782
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Match: H9JGH9 (Protein kinase domain-containing protein OS=Bombyx mori OX=7091 PE=4 SV=1)

HSP 1 Score: 258.84 bits (660), Expect = 7.331e-70
Identity = 238/883 (26.95%), Postives = 378/883 (42.81%), Query Frame = 1 
Query:  193 LISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSKRHRVAKMTRHETTALQHGFFRPPIKDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMG----LCNLYXXXXXXXXXXXXXREISNQDLT-RCTATNSDWSKFSILA--EG----DQDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDE 2808
            ++S++DG L   N ENG   W ++ PPL+S +L+  EF  +  + +L+PSL G LY +      + ++ LP     L S +F  S + +  GG D    G +  TG + Y+C  +GC  +     T+   D+L+  R +  +R +D   G+EKWNFS    ++                G  I    V    +  P N+  S +    ++  ++    ++ LW+ +L+A ++  W + +G +R        S   + Q+           L++G +Q  +Y+                 L   D +Q    + +     V   +R     L       P+ D  + ++  F  H  ++         V K  S+LF     F L + +  LIF     P+        +   +  +V     N   +  +P      +++    +  S   Y  RY+ D+  +R LG+G FGVVFEAR+ +D  +YAVKR+ +    E   ++L+E +A A+LEHP IVRY+ AW + P    +   D E       CN                 +S +D +    +T SD S F + A  EG    D  +    +R+        S    ++    +S         ++T        + LYI M L    SL DWL+  +  P      +    IF QIV AV Y+H  GL+HRDLKPSNI+F     +++ DFGL   M  +   P+   +A    +H     LT  VGTE+YMSPEQ Q+   Y  KVD++SLG+I +EL+ P  T  ERA  LT+ R   +     D +P+E    +                       +LNPDP  RPT   +     L +  DE
Sbjct:    1 MVSTLDGRLTAFNLENGTKAWVVETPPLLSSNLASSEFSGE-NRVKLVPSLRGSLYTVH----GSKIKRLPFNIHQLLSESFTESNNLITAGGHDILRIGIDTKTGRIIYKCNSNGCNNEQQ--TTETGGDVLVLTRQATAIRGLDPRTGIEKWNFSTAAHELQI------------SRGECIGDRTV----TESPVNMHVSMH---NQLVTVLSGDLNKPLWEHKLDAPITDVWELYDGNLRNSLWQDSRSSNIMGQM-----------LYVGDHQEQLYI-----------------LDEFDHSQKDRSLMV-----VPYQSRKRFIILDKENVYLPLSD--KSTNIPF--HEAEDSKKTEVSDKVKKVRSWLFDILTCFTLALALVLLIF-----PF------YARIRVMIMNVPQTTVNVVFNEDIP------SEKELEAKRPSNPEYPGRYEKDFTTVRRLGRGGFGVVFEARNNIDNCSYAVKRITLPRKKERHERVLREARALANLEHPHIVRYFNAWVQ-PCLASRRSSDCEANSISTTCNT----------------LSPKDASVELKSTASDNSSFVVFARSEGEAPPDGATGAAPERNDSTDKTRASSKRESKDDLASSMRKSQGDVTSSTEQTDCGLRLELYIQMQLCDPNSLYDWLRNNRDCPDRYQRAKV---IFGQIVSAVEYVHLEGLIHRDLKPSNIMFAPNGQVKVADFGLVAYMHDA---PALCGAARTPRAH---PQLTHRVGTEVYMSPEQLQRRP-YSYKVDIYSLGLILLELLQPFGTEAERAACLTRVRDQVYPDSFEDKYPKETAVLKL----------------------MLNPDPLLRPTASGVRARAPLFEATDE 754
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Match: R7TQJ3 (Protein kinase domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_190955 PE=4 SV=1)

HSP 1 Score: 244.202 bits (622), Expect = 3.473e-63
Identity = 174/634 (27.44%), Postives = 297/634 (46.85%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGC---------EQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTL-DKDSYPQSPLGEGGAVINSGCVLV-------------------------------QDSRDPGN----------VKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEF-------GCPRRRSLFLGAYQGHMYVQ----------------LEDGNGRSA-PRPRYVSLSGTDLTQTTLDISLSKRHRV------AKMTRHETTALQ-------HGFFRPPIKDLIEPSDAWFIQHG-KDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNL-----STDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKD 1806
            ++L+SSVDG L   N +NG + W++    LVS S+SK+E  +      LIPSL+G LY  + DG++  +  +P+ AD L SS+F+ + DS++VGGK+   +G +   G+++Y C  DGC         E  +++ R     ++L+  R +  +RA+++  G EKWNFSVGQ +V  + + D Y QS   +   +    CV+                                +D RD             V     V  G I  + +     +LW+Q+L+A+++  W +    ++ ++LF  D +  +    D+          P    +++G ++  +YVQ                +  G+  +  PR R++    T  ++T    +    H +      A +    T A+        +G++       I+  +A   + G KDE++    E + V   ++  +  +   ++ ++ HLI  +   P +                    P  S S+S+       ++ESK  +++         Y SRY TD+E + CLGKG FGVVF+A++++D  +YA+KR+ +  SD A+ K+++EVKA A L+H GIVRY QAWFE PP GWQE +D
Sbjct:   99 LILVSSVDGQLTAFNGKNGNIEWSVDTGTLVSSSISKIEMNRHGIPMHLIPSLDGGLY--QFDGEN--IEPVPLGADVLLSSSFRFNDDSMIVGGKETENYGIDVKEGKIRYICSMDGCQYKAEGPTEEPKTAYLRGDSEDEVLVISRHTKTIRAIEMRTGAEKWNFSVGQHEVSLVGENDGYTQSITHKNDEM--EECVIYEEEVCDEDDENIEEDADCEDCYIEDAEEIEEKDQRDKNEEEEINATSLPVDVKVIVPQGVIIGVSRDDPEEILWQQKLDAAVADAWTLMGKTLQPVSLFDADHNLALGVTNDDSEREDTKNSHPSSPVIYIGMHEDQLYVQPSIQMQKIVQATSTQIMTSGSASTKMPRVRWLPYLATASSRTPAVTARKNPHLLTYEKEEAVLGEEHTLAISPKQYPYDNGYYLFSDTTPIQLPNASSEKDGEKDEFF---DEEITVTLMNWWREVLVISIMMSILVHLILVKFCYPRR----------------PAIMPVPSSSASLISEEKDESNESKEAEDVVMLDQPLSQYSSRYRTDFEQVTCLGKGGFGVVFQAKNKLDDCDYAIKRIALNNSDRAKQKVMREVKALAKLDHVGIVRYNQAWFECPPPGWQEEQD 707

HSP 2 Score: 128.642 bits (322), Expect = 2.254e-26
Identity = 78/170 (45.88%), Postives = 94/170 (55.29%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALP---SGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            IYLYI M +    SLKDWL     +   R    CL   F QI+ AV Y+H  GLMHRDLKPSNI F     I++ DFGL T++         +    P   SGS   S+  T  VGTELYMSPEQ  +   Y QKVD+++LG+IF EL  P  T MER   L   RR+ F
Sbjct:  885 IYLYIQMQMCQRESLKDWLS---GNTLNRDRFECL-KFFHQILCAVDYVHQCGLMHRDLKPSNIFFSMDGVIKVGDFGLVTAL-------EENCEFTPDEKSGSKNKSKRYTDQVGTELYMSPEQSSRHP-YTQKVDIYALGMIFFELFYPFGTQMERIKTLQDIRRLVF 1042
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Match: eif2ak3 (eukaryotic translation initiation factor 2-alpha kinase 3 [Source:ZFIN;Acc:ZDB-GENE-050414-2])

HSP 1 Score: 137.502 bits (345), Expect = 1.556e-32
Identity = 75/167 (44.91%), Postives = 101/167 (60.48%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            +YLYI M L    +LKDW+  Q++ P  R  ++CL  IF QI +AV ++HS GLMHRDLKPSNI F   + +++ DFGL T+M + +       +  P   +      T  VGT+LYMSPE Q  G  Y  KVD++SLG+I  EL+ P  T MER   LT+ R +QF
Sbjct:  706 VYLYIQMQLCRKENLKDWMA-QRSQPEHREHSQCLA-IFLQIAEAVDFIHSKGLMHRDLKPSNIFFTLDDVVKVGDFGLVTAMDQEEDDDEDLSTLTPMPMYARH---TGQVGTKLYMSPE-QMSGNSYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQF 866

HSP 2 Score: 123.635 bits (309), Expect = 3.058e-28
Identity = 53/89 (59.55%), Postives = 70/89 (78.65%), Query Frame = 1 
Query: 1543 HYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
             Y SRY TD+E ++CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGI+RY+ AW E PP+GWQE  D+
Sbjct:  442 EYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNREVAREKVMREVKALAKLEHPGIIRYFNAWQESPPQGWQEEMDQ 530

HSP 3 Score: 81.2629 bits (199), Expect = 3.303e-15
Identity = 73/270 (27.04%), Postives = 117/270 (43.33%), Query Frame = 1 
Query:  331 LIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLG-----------------EGGAVI-------NSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHG----RIEQIQDEFGCPRRR-----SLFLGAYQGHMYVQ 1041
             IPSL+G L+  + + D   + A+P + ++L  S++++  D++LVGG            G   Y C   GC +        +  D+L+ +R    VRAV    G EKWNFSVG      L   S  QS LG                 +G  VI       N     +Q   D  N+    +V + ++ A    P  +++W+ Q    ++  WLV  G V  ++LF   ++     R  Q +D+      R     S++LG +QG +Y+Q
Sbjct:    2 FIPSLDGALF--QWNRDRESMEAVPFSVESLLDSSYRVGDDTVLVGGNPSPPTNTG---GLYPYICSAVGCSRWGD--EETEPEDMLLLQRTQKTVRAVTPRSGFEKWNFSVGN---FELKYVSEAQSQLGFLEGETGNKEVWHEIQPDGQRVILEDVESQNHANAHIQG--DGLNLVIKVSVPDWKVMAFSSEPGGQLIWEHQFCTPIASAWLVGGGKVTPISLFDDTTYTAHPEREPQEEDDDLMEEAREATESSVYLGMFQGQLYLQ 259
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687])

HSP 1 Score: 119.783 bits (299), Expect = 5.857e-27
Identity = 82/236 (34.75%), Postives = 119/236 (50.42%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLAT---SMMRSKPPPSADVSAL-----PSGSHGDSQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +      +R     L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT   +    K     + SAL     P+G      ++T  VGT LY+SPE Q      Y+QKVD+FSLGII  E+   P++T  ER  VL++ R+   +      FP +                  S  Q +  C LLN DP +RPT  ++    +L
Sbjct:  710 YLYIQMEYCEKSTLRDTIDQGLHRDCSR-----LWRLFREILDGIAYIHEQGMIHRDLKPVNIFLDSHDHVKIGDFGLATDHPATASEKLEIDDNNSALVLKSDPTG------NMTGMVGTALYVSPEVQGNTKATYNQKVDLFSLGIILFEMSYRPMATASERITVLSQLRKESID------FPEDF-------------GDYESGAQKKVICWLLNHDPARRPTAVELLKSDLL 915

HSP 2 Score: 68.9366 bits (167), Expect = 2.380e-11
Identity = 31/74 (41.89%), Postives = 47/74 (63.51%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E ++ LGKGAFG V + ++++D   YAVKR++V    +   ++  EV   + L H  IVRYY AW E
Sbjct:  492 SRYFSEFEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPGSKQFRRIKGEVTLLSRLNHENIVRYYNAWIE 565
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Match: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687])

HSP 1 Score: 119.398 bits (298), Expect = 8.577e-27
Identity = 80/232 (34.48%), Postives = 118/232 (50.86%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADV----SALPSGSHGDSQSLTSNVGTELYMSPE-QQQQGTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPIL 2790
            YLYI M      +L+D + +      +R     L  +F +I+D +AY+H  G++HRDLKP NI  D+ +H++I DFGLAT    +      ++    SAL   S   + ++T  VGT LY+SPE Q      Y+QKVD+FSLGII  E+   P++T  ER  VL++ R+   +      FP +                  S  Q +  C LLN DP +RPT  ++    +L
Sbjct:  676 YLYIQMEYCEKSTLRDTIDQGLHRDCSR-----LWRLFREILDGIAYIHEQGMIHRDLKPVNIFLDSHDHVKIGDFGLATDHPATAASEKLEIDDNNSALVLKS-DPTGNMTGMVGTALYVSPEVQGNTKATYNQKVDLFSLGIILFEMSYRPMATASERITVLSQLRKESID------FPEDF-------------GDYESGAQKKVICWLLNHDPARRPTAVELLKSDLL 882

HSP 2 Score: 68.9366 bits (167), Expect = 2.630e-11
Identity = 31/74 (41.89%), Postives = 47/74 (63.51%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E ++ LGKGAFG V + ++++D   YAVKR++V    +   ++  EV   + L H  IVRYY AW E
Sbjct:  458 SRYFSEFEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPGSKQFRRIKGEVTLLSRLNHENIVRYYNAWIE 531
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:103026818])

HSP 1 Score: 114.005 bits (284), Expect = 8.499e-26
Identity = 73/189 (38.62%), Postives = 104/189 (55.03%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTR--------C--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSH-GDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFP 2637
            H+ LYI M L   RSLKDW+QE+  +P               C    +I  +I++ V Y+HS G+MHRDLKP NI L  +  H++I DFGLA      K   +     L   SH G + + T+ VGT +Y SPEQ + G+ YD K D++S+G+I +EL  P  T MER   L + RR +    + +++P
Sbjct:  319 HLMLYIQMQL-CERSLKDWIQERNCTPKAELAVAGGPYQPFDCEEAFNILKKILEGVEYIHSCGIMHRDLKPRNIFLHGHACHVKIGDFGLAC-----KDIVANKQEQLHFNSHIGKNSAHTTGVGTFVYASPEQLE-GSHYDSKSDMYSVGVIAVELFHPFGTEMERVHTLGELRRGKVPDTLAENWP 500

HSP 2 Score: 70.8626 bits (172), Expect = 3.552e-12
Identity = 32/75 (42.67%), Postives = 53/75 (70.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVR-YSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E I  LGKG++G VF+ ++++D  +YAVK++ ++  S +   K+L+EVK  + L+HP IV Y+ AW E
Sbjct:  115 SRYLSEFEEISTLGKGSYGRVFKVKNKLDGQHYAVKKILIKNVSRDDCVKVLREVKVLSSLQHPNIVGYHTAWME 189
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Match: eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1 [Source:NCBI gene;Acc:103026818])

HSP 1 Score: 110.923 bits (276), Expect = 1.317e-24
Identity = 70/188 (37.23%), Postives = 105/188 (55.85%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTR--------C--LLHIFAQIVDAVAYLHSNGLMHRDLKPSNI-LFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFP 2637
            H+ LYI M L   RSLKDW+QE+  +P               C    +I  +I++ V Y+HS G+MHRDLKP NI L  +  H++I DFGLA   + +        ++   G + +S + T+ VGT +Y SPEQ + G+ YD K D++S+G+I +EL  P  T MER   L + RR +    + +++P
Sbjct:  365 HLMLYIQMQL-CERSLKDWIQERNCTPKAELAVAGGPYQPFDCEEAFNILKKILEGVEYIHSCGIMHRDLKPRNIFLHGHACHVKIGDFGLACKDIVANKQEQLHFNS-HIGKNAES-AHTTGVGTFVYASPEQLE-GSHYDSKSDMYSVGVIAVELFHPFGTEMERVHTLGELRRGKVPDTLAENWP 548

HSP 2 Score: 71.633 bits (174), Expect = 2.582e-12
Identity = 32/75 (42.67%), Postives = 53/75 (70.67%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVR-YSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +++E I  LGKG++G VF+ ++++D  +YAVK++ ++  S +   K+L+EVK  + L+HP IV Y+ AW E
Sbjct:  144 SRYLSEFEEISTLGKGSYGRVFKVKNKLDGQHYAVKKILIKNVSRDDCVKVLREVKVLSSLQHPNIVGYHTAWME 218
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006924.1 (pep scaffold:Pmarinus_7.0:GL476537:325917:352372:-1 gene:ENSPMAG00000006216.1 transcript:ENSPMAT00000006924.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 137.887 bits (346), Expect = 2.440e-33
Identity = 91/231 (39.39%), Postives = 118/231 (51.08%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF-EPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV 2799
            ++LYI M L    SLK+WL   +T+ A R    CL  IF QIV+AV +LH +GLMHRDLKPSNI F     ++I DFGL T     +    A ++ +P   H      T  VGT+LYMSPE Q  G  Y  KVD+FSLG+I  EL+ P  T MER   L+ AR   F +P+VT +                           +   RLL  DP  RP  E+I    + A++
Sbjct:  772 LFLYIQMQLCRKDSLKEWLN-SRTNAADRSRAECLT-IFQQIVNAVQFLHVSGLMHRDLKPSNIFFSLDGVVKIGDFGLVTGTEHEE--EGAVLTPMPGHIHH-----TGQVGTKLYMSPE-QLAGRAYSHKVDIFSLGLILFELLCPFGTQMERIKTLSAARNRIFPDPFVTSNVDEH-----------------------QLVERLLAQDPSLRPEAEEIAQAALFAEL 969

HSP 2 Score: 130.568 bits (327), Expect = 4.562e-31
Identity = 60/108 (55.56%), Postives = 80/108 (74.07%), Query Frame = 1 
Query: 1489 PGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKE 1812
            P  PA  E     NL+T  Y SRY TD+EH++CLG+G FGVVFEAR++VD  +YA+KR+R+    +AR K+++EVKA A LEH G+VRY+ AW E+PP+ WQE KDK+
Sbjct:  463 PNHPAQAE----DNLTT--YVSRYLTDFEHVQCLGRGGFGVVFEARNKVDDCHYAIKRIRLPNRIQAREKVMREVKALAKLEHQGVVRYFNAWLEMPPQDWQEEKDKQ 564

HSP 3 Score: 112.849 bits (281), Expect = 1.459e-25
Identity = 86/314 (27.39%), Postives = 148/314 (47.13%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVM-WNIKNPP--LVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGC---EQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPG--------NVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGD---------------SHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            +++IS++DG L  ++AE+G  + W +      L++ S+S  +     KK  +IPSL+G L+  + DGD   ++ALP T ++L  S+ +L  D +L+GGK    +G    TG++KY C   GC   ++D       D  DL++ +R+   VRAV    G EKWNFSVGQ D++                   N G    ++ + P         +V    +V +G++ A  K     V+W+ + ++ ++  WL+ +G V  ++LF  +                    + ++   G         G Y+G MY+Q
Sbjct:    2 LVIISTLDGQLTALDAESGGALRWRLDAGAGSLLASSISTNQAF--GKKL-IIPSLDGSLF--QWDGD--SMKALPFTVESLLDSSSRLGDDVVLMGGKAISTYGILADTGKLKYSCTSAGCRPWKEDDQV----DADDLVLVQRVQKTVRAVAPRSGAEKWNFSVGQYDIMFYRG---------------NEGNFQKEEDKSPDPEKLLQTMDVALKVSVPDGKVLAFRKAGAREVVWEHKFSSPVAAAWLLKDGQVLPVSLFDREVVPALEPDEREEDEEDDEEEDMVEAARGVAEPSVYLAGMYRGQMYIQ 289
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Match: eif2ak1 (eukaryotic translation initiation factor 2-alpha kinase 1 [Source:ZFIN;Acc:ZDB-GENE-061013-268])

HSP 1 Score: 110.538 bits (275), Expect = 2.069e-25
Identity = 81/241 (33.61%), Postives = 112/241 (46.47%), Query Frame = 1 
Query: 2107 HIYLYISMHLYSSRSLKDWLQE-----QQTSPA-----TRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDN-QNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILAD 2796
            H+ LYI M L   RSLK+WL +     QQ +        + TTR    +F Q+++ V Y+HS G+MHRDLKP NI      +H+RI DFGLA   +  + P      A   GS     + TS VGT LY +PE Q  G+ YD K D++S+GI+  EL  P  T MER   + + R        T  +P                      VQ ++   L   DP  RP  + I    ++ +
Sbjct:  301 HLVLYIQMQL-CERSLKEWLMDRNALLQQCTGRYALVDGKQTTR----MFQQLLEGVHYIHSRGIMHRDLKPRNIFLHGPDHHVRIGDFGLACQDIVYEDPRLIRAGAGVVGS-----AHTSGVGTTLYAAPE-QLSGSHYDFKSDMYSVGIVLFELFQPFGTEMERVKTIQELRGGVVSSPFTAQWP----------------------VQAKYIGLLTQDDPAARPNPQDILTTDLIGN 508

HSP 2 Score: 69.707 bits (169), Expect = 1.763e-12
Identity = 36/82 (43.90%), Postives = 56/82 (68.29%), Query Frame = 1 
Query: 1546 YESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEAR-SKLLQEVKAFAHLEHPGIVRYYQAWFEL--PP 1782
            + SRY +++E +  LG+G +G VF+ R+++D+  YAVK+V ++ S E+   K+L+EVK  A L+H  IV Y+ AW EL  PP
Sbjct:   97 HTSRYLSEFEEVCRLGRGGYGQVFKVRNKLDRQLYAVKKVLIKGSGESICKKVLREVKLLAGLQHLSIVGYHGAWLELLQPP 178
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007738.1 (pep scaffold:Pmarinus_7.0:GL476507:25231:69652:1 gene:ENSPMAG00000006975.1 transcript:ENSPMAT00000007738.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 105.916 bits (263), Expect = 2.911e-23
Identity = 77/232 (33.19%), Postives = 116/232 (50.00%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATS-MMRSKPPPSADVSA----LPSGSHGDSQSLTSNVGTELYMSPEQQQQ-GTRYDQKVDVFSLGIIFIELMV-PLSTGMERAVVLTKAR--RMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACR-LLNPDPDKRPTCEQIFN 2778
            +L+I M      +L+D + +       R     +  +F +I+D +AY+H  G++HRDLKP NI  D+ + ++I DFGLAT   + +      DVS     LP+ +   +  LT  +GT LY+SPE        Y+QKVD++SLGIIF E+   P++T  ER  VL K R   +QF     D  P+ ++                   Q  F  R LLN D  +RPT +++  
Sbjct:  835 HLFIQMEYCERSTLRDTIDKGLHMETDR-----MWRLFREILDGLAYIHEQGMIHRDLKPVNIFLDSSDSVKIGDFGLATDHRLVATESSKIDVSTANIELPTENMDVTGGLTGQIGTALYVSPEVLGNIKAVYNQKVDLYSLGIIFFEMTYHPMTTASERVAVLQKLRLPTIQFP---EDFHPQTLK-------------------QQAFIIRWLLNHDAGQRPTAQELLK 1039

HSP 2 Score: 70.4774 bits (171), Expect = 1.869e-12
Identity = 38/106 (35.85%), Postives = 57/106 (53.77%), Query Frame = 1 
Query: 1498 PATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAW---FELPPEGWQERKD 1806
            P+ D      +L +    SRY T++E +  LGKGAFG V + ++++D   YA+KR+ V  +     ++  EV   + L H  IVRYY AW   +EL P   +E  D
Sbjct:  592 PSRDILGMCSHLDSQRQLSRYYTEFEELALLGKGAFGAVIKVKNKLDGCYYALKRIAVNPTSRQFRRIKGEVTLLSRLNHENIVRYYNAWIERYELSPSDAKETPD 697
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001750.1 (pep scaffold:Pmarinus_7.0:GL481695:1137:12922:1 gene:ENSPMAG00000001576.1 transcript:ENSPMAT00000001750.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 78.1814 bits (191), Expect = 4.816e-15
Identity = 66/221 (29.86%), Postives = 104/221 (47.06%), Query Frame = 1 
Query: 2149 SLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDN-QNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERA-------VVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPI 2787
            +L +++Q++  S     T   +LH F QI  A+ ++HSN ++HRDLK  NIL D  Q  ++I DFG+ + ++ SK                 S++ T  VGT  Y+SPE   +G  Y+QK D+++LG I  EL       ++RA        ++ K     F P V+D +  E+R                     +    LLN DP KRP   ++ + P+
Sbjct:    3 TLAEYIQKRGGSLLDEDT---ILHFFVQIALALHHVHSNHILHRDLKTHNILLDKRQTVVKIGDFGI-SKILSSK-----------------SKAYTV-VGTPCYISPE-LCEGKPYNQKSDIWALGCILYEL-----ASLKRAFEAENLPALVLKIMSGNFAP-VSDRYSGELR---------------------QLVVSLLNLDPSKRPQLSEVLSHPV 173
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Match: nek2 (NIMA-related kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-752])

HSP 1 Score: 71.633 bits (174), Expect = 3.631e-13
Identity = 57/206 (27.67%), Postives = 95/206 (46.12%), Query Frame = 1 
Query: 2212 LLHIFAQIVDAVAYLH-----SNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIEL--MVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDE 2808
            +L + AQ+V A+   H        ++HRDLKP+N+  D ++++++ DFGLA  +                    D+    + VGT  YMSPEQ  + + Y++K D++SLG +  EL  +VP  T M +  +  K +  +F   +   +  E+                      E   ++LN     RP+ EQI    +LA+V+DE
Sbjct:   82 VLRVLAQLVLALRECHRRTAGGRTVLHRDLKPANVFLDARHNVKLGDFGLARIL------------------QHDTSFAKTFVGTPYYMSPEQFSRMS-YNEKSDIWSLGCLLYELCALVPPFTAMNQKQLAEKIKEGKFR-RIPYRYSDELN---------------------EIISKMLNLKDYLRPSIEQIMQYGLLAEVLDE 246
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Match: GCN2 (Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691])

HSP 1 Score: 125.176 bits (313), Expect = 1.834e-29
Identity = 75/221 (33.94%), Postives = 116/221 (52.49%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFN 2778
            L+I M    +R+L D +  +  +       R    +F QI++A++Y+HS G++HRDLKP NI  D   +++I DFGLA ++ RS      D   LP    G S +LTS +GT +Y++ E       Y++K+D++SLGIIF E++ P STGMER  +L K R +  E      FP +    +               V+ +    L++ DP+KRP    + N
Sbjct:  784 LFIQMEYCENRTLYDLIHSENLNQQRDEYWR----LFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP----GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSVSIE------FPPDFDDNKMK-------------VEKKIIRLLIDHDPNKRPGARTLLN 977

HSP 2 Score: 74.7146 bits (182), Expect = 5.818e-14
Identity = 35/74 (47.30%), Postives = 49/74 (66.22%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY +D+E I  LG+GAFG V +AR+ +D   YA+K  ++R+++E  S +L EV   A L H  +VRYY AW E
Sbjct:  593 SRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIK--KIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLE 664
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Match: KSP1 (Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001124])

HSP 1 Score: 75.8702 bits (185), Expect = 2.346e-14
Identity = 46/137 (33.58%), Postives = 73/137 (53.28%), Query Frame = 1 
Query: 2164 LQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQN-HIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQ-------QQQGTRYD-QKVDVFSLGIIFIELM 2547
            L E   + A    T+ + HI  QI+DA+ Y+H+ G+ HRD+KP NIL    +  I++ D+GLAT+                     D  S+  NVG+E YMSPE        +++   YD  KVD++++GI+F+ ++
Sbjct:  168 LYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLATT---------------------DKTSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIV 283
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Match: PKH2 (Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication [Source:SGD;Acc:S000005460])

HSP 1 Score: 75.8702 bits (185), Expect = 2.355e-14
Identity = 49/147 (33.33%), Postives = 74/147 (50.34%), Query Frame = 1 
Query: 2209 CLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVR 2649
            C  +  AQI+DA+ YLHSNG++HRD+KP NIL D +  I++ DFG A  +     P +  VS         S+S    VGT  Y+SPE     +  D + D+++ G I  +++            LT  + M+ +   T  FP  +R
Sbjct:  279 CARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLN----PTNNSVSKPEYDLSTRSKSF---VGTAEYVSPELLND-SFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIR 417
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Match: PKH3 (Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant [Source:SGD;Acc:S000002874])

HSP 1 Score: 74.7146 bits (182), Expect = 4.979e-14
Identity = 43/115 (37.39%), Postives = 67/115 (58.26%), Query Frame = 1 
Query: 2218 HIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHG--DSQSLTSNVGTELYMSPEQQQQGTRYDQ---KVDVFSLGIIFIELM 2547
            H  AQ++DA+ ++HS+G++HRDLKP N+L D    + I DFG A ++    P  S D +   S S+G  D+Q+  S VGT  Y+SPE       Y+Q     D+++LG +  + +
Sbjct:  117 HFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATI---DPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPEL----LLYNQCGYGSDIWALGCMIYQFV 224
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Match: KIN28 (Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002266])

HSP 1 Score: 71.2478 bits (173), Expect = 9.984e-14
Identity = 39/103 (37.86%), Postives = 55/103 (53.40%), Query Frame = 1 
Query: 2242 AVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMV 2550
             V + H N ++HRDLKP+N+LF     I++ DFGLA    R+ P P               + LTSNV T  Y +PE       Y   +D++S+G+IF ELM+
Sbjct:  116 GVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLA----RAIPAP--------------HEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELML 200
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Match: EDO48785 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIC0])

HSP 1 Score: 128.257 bits (321), Expect = 3.882e-30
Identity = 56/90 (62.22%), Postives = 71/90 (78.89%), Query Frame = 1 
Query: 1546 YESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEM 1815
            + SRY TD+EH  CLGKG FG+VF+AR++VD   YA+KRVR+   DEAR+K+++EVKA A LEH GIVRY+ AWFE PP GWQE  D++M
Sbjct:  482 FSSRYLTDFEHELCLGKGGFGLVFQARNKVDDCQYAIKRVRLPNCDEARAKVMREVKALAKLEHSGIVRYFNAWFEAPPVGWQEELDEKM 571

HSP 2 Score: 127.487 bits (319), Expect = 6.734e-30
Identity = 78/194 (40.21%), Postives = 101/194 (52.06%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSK--PPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARR--------------MQFEPWVTDSFPRE 2643
            +YLYI M L    SLKDWL+      +TR    C  ++F QIV+AV Y H+ G+MHRDLKPSNI F     +++ DFGL T+  +         D      G+H      T  VGT+LYMSPE Q +G  Y  KVD+FSLG+I  EL  P ST MER  V++  ++               Q   W+T   P E
Sbjct:  777 LYLYIQMQLCQRESLKDWLKNN----STREDIFCF-NVFEQIVNAVEYFHNRGMMHRDLKPSNIFFSLDGLVKVGDFGLVTATKQDNIHEIQETDNPGDLDGNH------TGQVGTQLYMSPE-QIEGKAYSFKVDIFSLGLILFELFHPFSTEMERIKVMSNVKKRIMPAEFKTSMTLQSQLVTWMTSDLPTE 958

HSP 3 Score: 119.013 bits (297), Expect = 2.985e-27
Identity = 88/310 (28.39%), Postives = 159/310 (51.29%), Query Frame = 1 
Query:  148 ADSITLNKIFFIRILLISSVDGNLCGINAEN-GQVMWNIKNPPLVS--QSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCE--QDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKP------PFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGD-SHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQ 1041
            A    ++++    ++++S++DG L  ++  N G + W++   P  S     S L   +   K R+IPSL+G LY   + GD   + ++P TAD+L  S  +L   S+LVGGK+    G +P+TG+V+Y C  +GC+  +D      ++  D+L+ +R    VRAVD   G E+WNFSVGQ DV  L+        +GE G   ++ C +  D+          ++ +G I A ++P          VLW  +  A ++  W +    ++ + LF+ +   G  + + ++     +  ++LG+++G +Y+Q
Sbjct:   41 AKGKNMSRMESCSLIIVSTLDGKLSALDGNNNGDLKWSL---PAFSGPLLSSSLSSFQTGNKVRVIPSLDGGLY--RVAGDT--IESIPYTADSLLGSFHKLQDGSMLVGGKEAISCGIDPYTGKVRYICSAEGCKLSEDEENGHVQNK-DVLVVKRTQQTVRAVDQRTGSERWNFSVGQQDVNFLEG-------IGEEG---DNKCAM-PDAEVSTEWDLRISIPDGLI-AAVQPQASGDIANEVVLWSHKFEAPIAAIWTLHGDYLKSVDLFSDEIMPGLRDGLPNQDTAEAKPIMYLGSHEGQVYIQ 330
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Match: EDO46416 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ17])

HSP 1 Score: 96.6709 bits (239), Expect = 1.604e-20
Identity = 72/200 (36.00%), Postives = 96/200 (48.00%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILF------DNQN----HIRIVDFGLATSMMRSKPPPSADVSA-----------LPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREV 2646
            + L+I M L ++ +L DWLQ +        T   +  IF QIV+ V Y+HS GLMHRDLKP NI        D Q      ++I DFGLA       P  S+ +++           LP  S  D+   T  VGT  Y +PEQ +  T Y  K D++SLGII  EL  P  T MER   +   R+       +  +P EV
Sbjct:  403 MMLFIQMQLCTT-TLCDWLQSRNFKGGNVDTVASM-AIFRQIVEGVRYIHSQGLMHRDLKPRNIFLQSLTRRDEQTTAPLQVKIGDFGLARKDAVLYPDTSSPLASLIEPLSHHNPFLPGLSTKDAP--TCGVGTCTYAAPEQLRN-TDYANKADMYSLGIILFELYWPFGTEMERVTSIKNLRQGNLPKAFSHRWPAEV 597

HSP 2 Score: 64.3142 bits (155), Expect = 1.695e-10
Identity = 30/75 (40.00%), Postives = 46/75 (61.33%), Query Frame = 1 
Query: 1552 SRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARS-KLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            SRY  ++  +  LGKG FG V + ++++D   YAVK+V ++ +D     K+L+EVK  A L H  +V Y+ AW E
Sbjct:  171 SRYKDEFVEMGRLGKGGFGSVLKVKNKLDGREYAVKKVLLKETDPGLCLKILREVKVLARLNHVNVVGYHSAWLE 245
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Match: EDO35070 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMJ7])

HSP 1 Score: 74.7146 bits (182), Expect = 3.999e-14
Identity = 38/108 (35.19%), Postives = 55/108 (50.93%), Query Frame = 1 
Query: 2227 AQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMV 2550
            ++I+  + ++H   + +RDLKP+NIL D   H+RI D GLA    + KP  S                    VGT  YM+PE  ++G  YD   D FSLG +  +L+V
Sbjct:  296 SEIILGLQHMHERKICYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--------------------VGTHGYMAPEVLKKGEAYDSCADWFSLGCMLFKLLV 383
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Match: EDO38062 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDX6])

HSP 1 Score: 73.1738 bits (178), Expect = 1.095e-13
Identity = 50/147 (34.01%), Postives = 75/147 (51.02%), Query Frame = 1 
Query: 2116 LYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSN-GLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQ---QQQGTRYDQKVDVFSLGIIFIEL 2544
            ++I M L  + SL D  ++  + P  R     L  I   +V A+ YLHSN  ++HRD+KPSNIL D + + ++ DFG+                   SG   DS + T + G + YM+PE+    +    YD + D++SLGI  IEL
Sbjct:  130 VWICMELMKT-SLYDLYKQVFSKPDRRIPEEVLGKIAVSVVSALEYLHSNLKVIHRDVKPSNILVDERGNFKLCDFGI-------------------SGQLVDSLAKTVDAGCKPYMAPERINPDRDMKGYDIRSDIWSLGITMIEL 256
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Match: EDO34534 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP26])

HSP 1 Score: 72.4034 bits (176), Expect = 1.333e-13
Identity = 42/118 (35.59%), Postives = 66/118 (55.93%), Query Frame = 1 
Query: 2203 TRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNH---IRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELM 2547
            T  LL +   +VD + YLH   ++HRDLKP+N+L+  Q+    ++I DFGL      SK   SA  S         S  + +NVG +++M+PE  +  +++ QK DVFS G++   +M
Sbjct:   18 TDALLTLSKDLVDGLHYLHGKSILHRDLKPNNLLYHFQDETPRLKIADFGL------SKDTTSASQS---------STVIGTNVGCKVWMAPEVSRAPSKHSQKSDVFSCGLVLHYIM 120
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Match: eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3 [Source:NCBI gene;Acc:101171373])

HSP 1 Score: 134.42 bits (337), Expect = 1.676e-31
Identity = 78/169 (46.15%), Postives = 99/169 (58.58%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            +YLYI M L    +LKDW+  Q+  P  R   +CL  IF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M     +  PS    A     H      T  VGT+LYMSPE Q  G  Y  KVD++SLG+I  EL+ P  T MER   LT+ R ++F
Sbjct:  864 VYLYIQMQLCRKENLKDWMA-QRCLPEQREHNQCL-DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEEDEDEPSTLTPAPLLTRH------TGQVGTKLYMSPE-QLSGNSYSHKVDIYSLGLILFELLYPFRTQMERVRTLTEVRVLRF 1023

HSP 2 Score: 125.176 bits (313), Expect = 1.032e-28
Identity = 54/93 (58.06%), Postives = 72/93 (77.42%), Query Frame = 1 
Query: 1531 LSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            + +  Y SRY TD+E ++CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGI+RY+ AW E PPEGWQE  D+
Sbjct:  586 IRSSEYVSRYLTDFEPMQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAWQESPPEGWQEEMDQ 678

HSP 3 Score: 98.9821 bits (245), Expect = 1.484e-20
Identity = 79/311 (25.40%), Postives = 146/311 (46.95%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVG----------QDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGN------VKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQ---IQDEFGCPRR------RSLFLGAYQGHMYVQ 1041
            +++IS++DG +  ++  N G+  W++        S S  +      K  +IPSL+G L+  + + D   + A+P + ++L  S++++  D++LVGGK    +G   ++G+++Y C   GC +        +  D+L+ +R    VRAV    G EKWNFSVG          Q  +  L+ +   + P  +   VI       +   D  N      +    +V + ++ A  + P  +++W+ Q    ++  WLV  G V  ++LF  D  G   Q     ++   P +       S++LG +QG +Y+Q
Sbjct:  103 LVIISTLDGRISALDPHNQGRKQWDLDVGSGSLVSSSLSKPEVFGNKM-VIPSLDGALF--QWNRDRESMEAVPFSVESLLESSYRIGEDTVLVGGKSLTTYGLGAYSGKLRYICSAGGCNRWGE--DEGEAEDVLLLQRTQKTVRAVRPRSGTEKWNFSVGNFELKLLPEIQSGMNFLEGEMTNEDPWNDNQRVITDEPKDREKREDKQNQNQHSDLVIKVSVPDWKVMAFTE-PNEQLVWEHQFCTPIASAWLVGGGKVTPISLF--DDTGYRSQSETEDEDDEDPSKSRGSAESSVYLGMFQGQLYLQ 405
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Match: eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3 [Source:NCBI gene;Acc:101171373])

HSP 1 Score: 131.724 bits (330), Expect = 9.393e-31
Identity = 77/169 (45.56%), Postives = 97/169 (57.40%), Query Frame = 1 
Query: 2110 IYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSM--MRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQF 2610
            +YLYI M L    +LKDW+  Q+  P  R   +CL  IF QI +AV +LHS GLMHRDLKPSNI F   + +++ DFGL T+M     +  PS    A     H      T  VGT+LYMSPE Q  G  Y  KVD++SLG+I  EL+ P  T MER  V  + + M F
Sbjct:  791 VYLYIQMQLCRKENLKDWMA-QRCLPEQREHNQCL-DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEEDEDEPSTLTPAPLLTRH------TGQVGTKLYMSPE-QLSGNSYSHKVDIYSLGLILFELLYPFRTQMERVRVSEQTKSMDF 950

HSP 2 Score: 125.561 bits (314), Expect = 8.443e-29
Identity = 54/93 (58.06%), Postives = 72/93 (77.42%), Query Frame = 1 
Query: 1531 LSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDK 1809
            + +  Y SRY TD+E ++CLG+G FGVVFEAR++VD  NYA+KR+R+   + AR K+++EVKA A LEHPGI+RY+ AW E PPEGWQE  D+
Sbjct:  513 IRSSEYVSRYLTDFEPMQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAWQESPPEGWQEEMDQ 605

HSP 3 Score: 100.138 bits (248), Expect = 6.425e-21
Identity = 79/313 (25.24%), Postives = 147/313 (46.96%), Query Frame = 1 
Query:  181 IRILLISSVDGNLCGINAEN-GQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVG----------QDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGN------VKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQ---IQDEFGCPRR------RSLFLGAYQGHMYVQ 1041
            + +++IS++DG +  ++  N G+  W++        S S  +      K  +IPSL+G L+  + + D   + A+P + ++L  S++++  D++LVGGK    +G   ++G+++Y C   GC +        +  D+L+ +R    VRAV    G EKWNFSVG          Q  +  L+ +   + P  +   VI       +   D  N      +    +V + ++ A  + P  +++W+ Q    ++  WLV  G V  ++LF  D  G   Q     ++   P +       S++LG +QG +Y+Q
Sbjct:   28 LSLVIISTLDGRISALDPHNQGRKQWDLDVGSGSLVSSSLSKPEVFGNKM-VIPSLDGALF--QWNRDRESMEAVPFSVESLLESSYRIGEDTVLVGGKSLTTYGLGAYSGKLRYICSAGGCNRWGE--DEGEAEDVLLLQRTQKTVRAVRPRSGTEKWNFSVGNFELKLLPEIQSGMNFLEGEMTNEDPWNDNQRVITDEPKDREKREDKQNQNQHSDLVIKVSVPDWKVMAFTE-PNEQLVWEHQFCTPIASAWLVGGGKVTPISLF--DDTGYRSQSETEDEDDEDPSKSRGSAESSVYLGMFQGQLYLQ 332
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000043016.1 (interferon-induced, double-stranded RNA-activated protein kinase [Source:NCBI gene;Acc:100144382])

HSP 1 Score: 125.946 bits (315), Expect = 1.846e-29
Identity = 70/178 (39.33%), Postives = 97/178 (54.49%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC-LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPRE 2643
            +LYI M L  S +LKDW++++          R   L I  QI+  V Y+HSNGL+HRDLKP+NI+F   N ++I DFGL T+                     + +   S  GT++YM+PE  Q    Y QKVD+F+LG+IF EL+  L TG ER  +   ARR +F     ++FP E
Sbjct:  413 FLYIQMELCRSETLKDWIKDKNRKDLQAYQRRGESLPIALQIISGVEYIHSNGLIHRDLKPANIMFGMDNKVKIGDFGLVTT----------------EAVDDEKRMARSKTGTKVYMAPE--QTSGNYGQKVDMFALGLIFFELLWKLWTGHERVQIWENARRKKFPAQFLETFPEE 572

HSP 2 Score: 59.3066 bits (142), Expect = 1.428e-8
Identity = 34/97 (35.05%), Postives = 52/97 (53.61%), Query Frame = 1 
Query: 1501 ATDESKTFQNLSTDHY------ESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            ++++SK  +N+ T         +SR++ +Y+ +  +GKG FG V++ R+R+    YAVK V          K  QE    A L+H  IVRYY AW E
Sbjct:  300 SSNDSKAQENVGTKKVGNRNVSKSRFEREYDILGRIGKGGFGRVYKVRNRLINREYAVKIV------SGTEKAKQEASTLAKLQHDNIVRYYIAWME 390
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000015563.2 (interferon-induced, double-stranded RNA-activated protein kinase [Source:NCBI gene;Acc:100144382])

HSP 1 Score: 125.561 bits (314), Expect = 2.723e-29
Identity = 70/178 (39.33%), Postives = 97/178 (54.49%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC-LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPRE 2643
            +LYI M L  S +LKDW++++          R   L I  QI+  V Y+HSNGL+HRDLKP+NI+F   N ++I DFGL T+                     + +   S  GT++YM+PE  Q    Y QKVD+F+LG+IF EL+  L TG ER  +   ARR +F     ++FP E
Sbjct:  435 FLYIQMELCRSETLKDWIKDKNRKDLQAYQRRGESLPIALQIISGVEYIHSNGLIHRDLKPANIMFGMDNKVKIGDFGLVTT----------------EAVDDEKRMARSKTGTKVYMAPE--QTSGNYGQKVDMFALGLIFFELLWKLWTGHERVQIWENARRKKFPAQFLETFPEE 594

HSP 2 Score: 55.8398 bits (133), Expect = 2.056e-7
Identity = 29/73 (39.73%), Postives = 40/73 (54.79%), Query Frame = 1 
Query: 1555 RYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFE 1773
            R++ +Y+ +  +GKG FG V++ R+R+    YAVK V          K  QE    A L+H  IVRYY AW E
Sbjct:  346 RFEREYDILGRIGKGGFGRVYKVRNRLINREYAVKIV------SGTEKAKQEASTLAKLQHDNIVRYYIAWME 412
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000015565.2 (interferon-induced, double-stranded RNA-activated protein kinase [Source:NCBI gene;Acc:100144382])

HSP 1 Score: 113.235 bits (282), Expect = 4.190e-27
Identity = 64/158 (40.51%), Postives = 87/158 (55.06%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRC-LLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVV 2583
            +LYI M L  S +LKDW++++          R   L I  QI+  V Y+HSNGL+HRDLKP+NI+F   N ++I DFGL T+                     + +   S  GT++YM+PEQ      Y QKVD+F+LG+IF EL+  L TG ER  V
Sbjct:  112 FLYIQMELCRSETLKDWIKDKNRKDLQAYQRRGESLPIALQIISGVEYIHSNGLIHRDLKPANIMFGMDNKVKIGDFGLVTT----------------EAVDDEKRMARSKTGTKVYMAPEQTS--GNYGQKVDMFALGLIFFELLWKLWTGHERVQV 251
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Match: SMESG000032681.1 (SMESG000032681.1)

HSP 1 Score: 944.495 bits (2440), Expect = 0.000e+0
Identity = 534/541 (98.71%), Postives = 536/541 (99.08%), Query Frame = 1 
Query: 1210 IKDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYXXXXXXXXXXXXXREISNQDLTRCTATNSDWSKFSILAEGDQDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR 2832
            ++DLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRSNAQQSNNINQSVCLQAPNASLSSSVPCPGGP TDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYDDDMSVSSSSDQSREISNQD TRCTATNSDWSKFSILAEGDQDSLIIFDRSAVAPS SESVSMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFA  PPISSDIILIIASCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR
Sbjct:    2 LQDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRSNAQQSNNINQSVCLQAPNASLSSSVPCPGGPVTDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYDDDMSVSSSSDQSREISNQDSTRCTATNSDWSKFSILAEGDQDSLIIFDRSAVAPSGSESVSMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFA--PPISSDIILIIASCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR 540
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Match: SMESG000032678.1 (SMESG000032678.1)

HSP 1 Score: 926.391 bits (2393), Expect = 0.000e+0
Identity = 514/541 (95.01%), Postives = 516/541 (95.38%), Query Frame = 1 
Query: 1210 IKDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRXXXXXXXXXXXXVCLQAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYXXXXXXXXXXXXXREISNQDLTRCTATNSDWSKFSILAEGDQDSLIIFDRXXXXXXXXXXXXMTNRXXXXXXXXXXXXXXXXXXXXXXXXXHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR 2832
            ++DLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRSNAQQSNNINQSVCLQAPNASLSSSVPCPGGP TDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYDDDMSVSSSSDQSREISNQD TRCTATNSDWSKFSILAEGDQDSLIIFDRSAVAPS SESVSMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPRE                      VEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR
Sbjct:    2 LQDLIEPSDAWFIQHGKDEYYPPSTEPLVVKYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRSNAQQSNNINQSVCLQAPNASLSSSVPCPGGPVTDESKTFQNLSTDHYESRYDTDYEHIRCLGKGAFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIVRYYQAWFELPPEGWQERKDKEMGLCNLYDDDMSVSSSSDQSREISNQDSTRCTATNSDWSKFSILAEGDQDSLIIFDRSAVAPSGSESVSMTNRSVAPASGALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYDQKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPRE----------------------VEFACRLLNPDPDKRPTCEQIFNDPILADVVDEVRNCHRMR 520
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Match: SMESG000032676.1 (SMESG000032676.1)

HSP 1 Score: 708.368 bits (1827), Expect = 0.000e+0
Identity = 342/343 (99.71%), Postives = 343/343 (100.00%), Query Frame = 1 
Query:  187 ILLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSKRHRVAKMTRHETTALQHGFFRPPIK 1215
            +LLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSKRHRVAKMTRHETTALQHGFFRPPIK
Sbjct:   37 VLLISSVDGNLCGINAENGQVMWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRALPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQDSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKDSYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFHRVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRRSLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSKRHRVAKMTRHETTALQHGFFRPPIK 379
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Match: SMESG000017261.1 (SMESG000017261.1)

HSP 1 Score: 83.1889 bits (204), Expect = 4.103e-16
Identity = 59/227 (25.99%), Postives = 103/227 (45.37%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPE---QQQQGTRYDQKVDVFSLGIIFIELMV---PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIF 2775
            +L I M   S  SL+D ++ +++       T  ++    QI++ + +LH N ++HRD+KP NIL  N N+I+I DFG++ S++R               + G+     + +GT  + +PE      +G  Y    D++SLG   I ++    P       AVV   A   + +   + S  +E++                     EF  ++L+PDPD+R T  Q+ 
Sbjct:  375 HLCIFMEYLSGGSLEDEIKRKRSL-----ATENIIRYSKQILEGLEFLHGNNIIHRDIKPDNILMSNGNNIKITDFGVSRSLLR---------------TCGNVTKAETTIGTPNFTAPEVFLTSDEGPPYTVSADIWSLGATVINMITGRPPYCGCHPYAVVKKIADTKKLDLPDSQSMSKEMK---------------------EFIEKMLDPDPDQRSTAAQLL 560
[Close]
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Match: SMESG000017261.1 (SMESG000017261.1)

HSP 1 Score: 83.1889 bits (204), Expect = 4.486e-16
Identity = 59/227 (25.99%), Postives = 103/227 (45.37%), Query Frame = 1 
Query: 2113 YLYISMHLYSSRSLKDWLQEQQTSPATRPTTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLATSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPE---QQQQGTRYDQKVDVFSLGIIFIELMV---PLSTGMERAVVLTKARRMQFEPWVTDSFPREVRFARXXXXXXXXXXXXXXCVQVEFACRLLNPDPDKRPTCEQIF 2775
            +L I M   S  SL+D ++ +++       T  ++    QI++ + +LH N ++HRD+KP NIL  N N+I+I DFG++ S++R               + G+     + +GT  + +PE      +G  Y    D++SLG   I ++    P       AVV   A   + +   + S  +E++                     EF  ++L+PDPD+R T  Q+ 
Sbjct:  441 HLCIFMEYLSGGSLEDEIKRKRSL-----ATENIIRYSKQILEGLEFLHGNNIIHRDIKPDNILMSNGNNIKITDFGVSRSLLR---------------TCGNVTKAETTIGTPNFTAPEVFLTSDEGPPYTVSADIWSLGATVINMITGRPPYCGCHPYAVVKKIADTKKLDLPDSQSMSKEMK---------------------EFIEKMLDPDPDQRSTAAQLL 626
The following BLAST results are available for this feature:
BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
EIF2AK34.354e-3538.26eukaryotic translation initiation factor 2 alpha k... [more]
EIF2AK43.841e-2635.90eukaryotic translation initiation factor 2 alpha k... [more]
EIF2AK42.497e-2437.20eukaryotic translation initiation factor 2 alpha k... [more]
EIF2AK16.840e-2235.08eukaryotic translation initiation factor 2 alpha k... [more]
EIF2AK28.255e-1631.68eukaryotic translation initiation factor 2 alpha k... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pek-15.352e-2227.17Eukaryotic translation initiation factor 2-alpha k... [more]
Y38E10A.82.713e-1835.57pep chromosome:WBcel235:II:12607200:12608788:1 gen... [more]
gcn-22.560e-1628.03Eukaryotic translation initiation factor 2-alpha k... [more]
gcn-22.560e-1628.03Eukaryotic translation initiation factor 2-alpha k... [more]
gcn-22.560e-1628.03Eukaryotic translation initiation factor 2-alpha k... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PEK3.047e-3139.56gene:FBgn0037327 transcript:FBtr0330027[more]
PEK3.671e-3139.56gene:FBgn0037327 transcript:FBtr0078770[more]
PEK3.986e-3139.56gene:FBgn0037327 transcript:FBtr0330026[more]
Gcn24.948e-1928.88gene:FBgn0019990 transcript:FBtr0334551[more]
Gcn24.948e-1928.88gene:FBgn0019990 transcript:FBtr0085787[more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2ak31.709e-3245.83eukaryotic translation initiation factor 2-alpha k... [more]
BX072573.11.831e-3245.83eukaryotic translation initiation factor 2-alpha k... [more]
eif2ak12.564e-2832.79eukaryotic translation initiation factor 2-alpha k... [more]
eif2ak12.752e-2832.79eukaryotic translation initiation factor 2-alpha k... [more]
eif2ak17.560e-2832.38eukaryotic translation initiation factor 2-alpha k... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpt1al4.679e-3538.36carnitine palmitoyltransferase 1A (liver) like [So... [more]
cpt1al4.907e-3538.36carnitine palmitoyltransferase 1A (liver) like [So... [more]
cpt1al4.950e-3538.36carnitine palmitoyltransferase 1A (liver) like [So... [more]
cpt1al5.168e-3538.36carnitine palmitoyltransferase 1A (liver) like [So... [more]
cpt1al5.346e-3538.36carnitine palmitoyltransferase 1A (liver) like [So... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Eif2ak38.201e-5327.87eukaryotic translation initiation factor 2 alpha k... [more]
Eif2ak42.634e-2636.68eukaryotic translation initiation factor 2 alpha k... [more]
Eif2ak42.842e-2636.68eukaryotic translation initiation factor 2 alpha k... [more]
Eif2ak42.850e-2636.68eukaryotic translation initiation factor 2 alpha k... [more]
Eif2ak42.880e-2636.68eukaryotic translation initiation factor 2 alpha k... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9Z1Z1|E2AK3_RAT1.636e-5329.27Eukaryotic translation initiation factor 2-alpha k... [more]
sp|Q9Z2B5|E2AK3_MOUSE1.136e-5127.87Eukaryotic translation initiation factor 2-alpha k... [more]
sp|Q9NZJ5|E2AK3_HUMAN2.091e-3438.26Eukaryotic translation initiation factor 2-alpha k... [more]
sp|Q9NIV1|E2AK3_DROME3.679e-3039.56Eukaryotic translation initiation factor 2-alpha k... [more]
sp|P15442|GCN2_YEAST1.273e-2733.94eIF-2-alpha kinase GCN2 OS=Saccharomyces cerevisia... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
G4VBQ01.015e-10129.01Protein kinase OS=Schistosoma mansoni OX=6183 GN=S... [more]
A0A5N4AV157.131e-7327.73Uncharacterized protein OS=Photinus pyralis OX=705... [more]
A0A1Y1KD938.102e-7327.73Protein kinase domain-containing protein OS=Photin... [more]
H9JGH97.331e-7026.95Protein kinase domain-containing protein OS=Bombyx... [more]
R7TQJ33.473e-6327.44Protein kinase domain-containing protein OS=Capite... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2ak31.556e-3244.91eukaryotic translation initiation factor 2-alpha k... [more]
EIF2AK45.857e-2734.75eukaryotic translation initiation factor 2 alpha k... [more]
EIF2AK48.577e-2734.48eukaryotic translation initiation factor 2 alpha k... [more]
eif2ak18.499e-2638.62eukaryotic translation initiation factor 2 alpha k... [more]
eif2ak11.317e-2437.23eukaryotic translation initiation factor 2 alpha k... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006924.12.440e-3339.39pep scaffold:Pmarinus_7.0:GL476537:325917:352372:-... [more]
eif2ak12.069e-2533.61eukaryotic translation initiation factor 2-alpha k... [more]
ENSPMAT00000007738.12.911e-2333.19pep scaffold:Pmarinus_7.0:GL476507:25231:69652:1 g... [more]
ENSPMAT00000001750.14.816e-1529.86pep scaffold:Pmarinus_7.0:GL481695:1137:12922:1 ge... [more]
nek23.631e-1327.67NIMA-related kinase 2 [Source:ZFIN;Acc:ZDB-GENE-04... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
GCN21.834e-2933.94Protein kinase; phosphorylates the alpha-subunit o... [more]
KSP12.346e-1433.58Serine/threonine protein kinase; associates with T... [more]
PKH22.355e-1433.33Serine/threonine protein kinase; involved in sphin... [more]
PKH34.979e-1437.39Protein kinase with similarity to mammalian PDK1 a... [more]
KIN289.984e-1437.86Serine/threonine protein kinase, subunit of transc... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO487853.882e-3062.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO464161.604e-2036.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO350703.999e-1435.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO380621.095e-1334.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO345341.333e-1335.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2ak31.676e-3146.15eukaryotic translation initiation factor 2 alpha k... [more]
eif2ak39.393e-3145.56eukaryotic translation initiation factor 2 alpha k... [more]
ENSORLT00000043016.11.846e-2939.33interferon-induced, double-stranded RNA-activated ... [more]
ENSORLT00000015563.22.723e-2939.33interferon-induced, double-stranded RNA-activated ... [more]
ENSORLT00000015565.24.190e-2740.51interferon-induced, double-stranded RNA-activated ... [more]
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BLAST of Eukaryotic translation initiation factor 2-alpha kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000032681.10.000e+098.71SMESG000032681.1[more]
SMESG000032678.10.000e+095.01SMESG000032678.1[more]
SMESG000032676.10.000e+099.71SMESG000032676.1[more]
SMESG000017261.14.103e-1625.99SMESG000017261.1[more]
SMESG000017261.14.486e-1625.99SMESG000017261.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30006989 ID=SMED30006989|Name=Eukaryotic translation initiation factor 2-alpha kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2977bp
GGTCAGGAACATGAAATGACGTTGAATTAAAATGAAATTTAAAATTTATT
AATCTCATTAATTTTTATGTAAATATTTGCACAATGAAATATTTTTTACT
ATTACTAGTTTATTCCTTTCTGTATTTTTCTTCATCCTGTGAAGAATGCG
GATTCAATTACTCTCAACAAAATTTTTTTCATCAGAATTTTACTTATTAG
TTCCGTAGATGGGAATCTGTGCGGAATCAACGCTGAAAATGGTCAAGTGA
TGTGGAATATCAAAAATCCACCTTTAGTTTCACAAAGTTTAAGCAAATTG
GAGTTTATAAAAGATGCTAAGAAATTCCGTTTAATTCCGTCATTGGAAGG
GCAATTGTATATGCTGGAAATTGATGGCGATGACAACGGATTGCGCGCGC
TGCCCATCACTGCAGATGCATTATTCTCCTCGACATTTCAATTGTCAGCT
GATTCATTGCTCGTTGGTGGAAAGGATCAACGGGTTTTTGGGTTCAATCC
CTTTACTGGCGAGGTAAAGTACCGATGTGGCAAGGACGGATGTGAACAGG
ACTCCTCATTTCCTCGTACCAAGGACACCTGTGATCTACTGATTTGTCGG
CGGATCAGCCATGTCGTAAGAGCGGTCGACCTGGAAATCGGGCTGGAGAA
ATGGAACTTTTCAGTTGGACAAGATGATGTTGTGACCCTGGATAAAGATT
CATATCCGCAAAGCCCTCTAGGTGAAGGAGGAGCTGTGATTAATAGCGGC
TGTGTTCTGGTTCAGGACAGCAGAGATCCTGGCAATGTCAAATATTCATT
TAATGTAGAAAATGGGGAGATAGAAGCAATTATTAAGCCGCCTTTTCATC
GGGTTTTGTGGAAGCAGCAATTAAATGCCAGCCTCAGTCGAGGGTGGTTG
GTAGACAATGGCTTGGTGAGACAGCTGGCTCTGTTTGCAGGTGATTCCCA
CGGTAGGATAGAGCAAATTCAGGATGAATTTGGCTGTCCACGACGTCGGT
CCCTGTTTCTTGGCGCTTATCAGGGTCACATGTACGTTCAACTGGAGGAT
GGTAACGGTCGATCCGCACCGAGGCCCCGATACGTCTCCCTCTCAGGAAC
TGATCTAACACAAACCACATTAGATATTTCACTCAGCAAACGTCACAGAG
TTGCTAAAATGACGCGCCATGAAACTACTGCCTTACAACATGGCTTTTTC
CGACCTCCCATTAAGGACCTAATCGAGCCCAGTGATGCTTGGTTCATTCA
ACATGGAAAGGATGAATATTATCCCCCGTCGACTGAGCCATTGGTTGTGA
AATATGGATCATTCTTGTTCCAGAAATTCATTTTCTTTTGTCTGGTTGTC
GTGATATTCCACCTGATATTCACCCGCATTTACTTGCCGTACCAATTATA
CCGAAGTAATGCTCAGCAATCAAACAATATCAACCAATCCGTTTGCTTAC
AGGCCCCAAATGCTTCTCTATCATCATCTGTTCCCTGTCCAGGCGGTCCC
GCCACAGATGAAAGCAAAACCTTTCAAAATTTAAGCACTGATCATTATGA
GTCCAGATATGATACTGATTATGAGCACATCCGATGTCTGGGCAAAGGTG
CTTTTGGTGTGGTATTTGAGGCGCGTCACCGGGTTGATCAATACAATTAT
GCGGTGAAACGCGTCCGCGTCCGCTACAGTGATGAGGCGCGTTCAAAACT
ATTGCAAGAAGTCAAAGCTTTCGCTCATCTTGAACATCCGGGAATCGTAA
GGTATTATCAAGCCTGGTTTGAGTTGCCGCCTGAAGGCTGGCAGGAAAGA
AAGGATAAAGAAATGGGCCTGTGCAATCTATATGATGATGACATGAGCGT
ATCCAGCAGCTCGGACCAATCTCGAGAAATTTCCAATCAAGATTTGACTC
GTTGCACTGCTACTAATAGTGATTGGTCCAAATTTAGCATTTTGGCCGAG
GGCGACCAGGACAGCTTGATAATTTTTGACAGGTCAGCTGTTGCTCCCTC
AGCCAGTGAATCGGTTTCCATGACAAATCGCTCGGTGGCGCCGGCCTCCG
GTGCCCTCGGTGCCTCCGGTGCCGCCAATAATACCAGCAACAACATGAAC
TGCTCTCACATCTATCTCTACATCTCCATGCACTTGTACAGCTCCCGCAG
CCTCAAGGACTGGCTCCAGGAGCAGCAGACGTCACCAGCTACTCGGCCGA
CTACCCGATGCCTCCTGCACATATTTGCTCAGATAGTCGATGCGGTTGCC
TACCTGCACTCAAACGGCCTCATGCACAGAGATCTCAAGCCGTCCAATAT
CCTGTTCGATAACCAGAATCACATCAGGATTGTCGATTTCGGTTTGGCCA
CCTCCATGATGCGCAGCAAGCCTCCGCCGAGTGCCGATGTTTCGGCACTA
CCCAGCGGTAGCCATGGCGACAGCCAATCACTCACCAGCAACGTCGGCAC
CGAGCTCTACATGAGTCCAGAGCAGCAGCAGCAAGGCACGCGTTATGATC
AGAAGGTCGATGTGTTCTCCTTGGGTATCATATTCATTGAGCTGATGGTT
CCTCTCTCGACAGGCATGGAACGCGCGGTGGTCCTCACCAAGGCCAGGAG
GATGCAGTTCGAGCCCTGGGTAACTGACAGTTTCCCCCGCGAGGTGAGAT
TTGCCCGCCCCCCCCCTATCTCATCTGACATCATATTGATTATTGCCTCT
TGCGTTCAGGTCGAATTCGCCTGCCGCCTCCTGAATCCGGACCCGGACAA
GCGGCCCACTTGTGAGCAAATATTCAATGATCCGATCTTGGCTGACGTTG
TCGATGAGGTGAGGAATTGCCATCGGATGCGGTCAGTTTCCTCCGGTGCC
GCAACCGGTGCTGCCGGTGCCAGCGGTACCGTTTGATGGGGTCAGCAGCA
GTTCCTGGCCCGGCTGTGATACATTTGTATATTTTATAACCAGATGGCAA
TCATGATAATAAATGTCTATTTCCGTT
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protein sequence of SMED30006989-orf-1

>SMED30006989-orf-1 ID=SMED30006989-orf-1|Name=SMED30006989-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=879bp
MWNIKNPPLVSQSLSKLEFIKDAKKFRLIPSLEGQLYMLEIDGDDNGLRA
LPITADALFSSTFQLSADSLLVGGKDQRVFGFNPFTGEVKYRCGKDGCEQ
DSSFPRTKDTCDLLICRRISHVVRAVDLEIGLEKWNFSVGQDDVVTLDKD
SYPQSPLGEGGAVINSGCVLVQDSRDPGNVKYSFNVENGEIEAIIKPPFH
RVLWKQQLNASLSRGWLVDNGLVRQLALFAGDSHGRIEQIQDEFGCPRRR
SLFLGAYQGHMYVQLEDGNGRSAPRPRYVSLSGTDLTQTTLDISLSKRHR
VAKMTRHETTALQHGFFRPPIKDLIEPSDAWFIQHGKDEYYPPSTEPLVV
KYGSFLFQKFIFFCLVVVIFHLIFTRIYLPYQLYRSNAQQSNNINQSVCL
QAPNASLSSSVPCPGGPATDESKTFQNLSTDHYESRYDTDYEHIRCLGKG
AFGVVFEARHRVDQYNYAVKRVRVRYSDEARSKLLQEVKAFAHLEHPGIV
RYYQAWFELPPEGWQERKDKEMGLCNLYDDDMSVSSSSDQSREISNQDLT
RCTATNSDWSKFSILAEGDQDSLIIFDRSAVAPSASESVSMTNRSVAPAS
GALGASGAANNTSNNMNCSHIYLYISMHLYSSRSLKDWLQEQQTSPATRP
TTRCLLHIFAQIVDAVAYLHSNGLMHRDLKPSNILFDNQNHIRIVDFGLA
TSMMRSKPPPSADVSALPSGSHGDSQSLTSNVGTELYMSPEQQQQGTRYD
QKVDVFSLGIIFIELMVPLSTGMERAVVLTKARRMQFEPWVTDSFPREVR
FARPPPISSDIILIIASCVQVEFACRLLNPDPDKRPTCEQIFNDPILADV
VDEVRNCHRMRSVSSGAATGAAGASGTV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003743translation initiation factor activity
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0004694eukaryotic translation initiation factor 2alpha kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
GO:0019899enzyme binding
GO:0019903protein phosphatase binding
GO:0042802identical protein binding
GO:0051879Hsp90 protein binding
Vocabulary: biological process
TermDefinition
GO:0006413translational initiation
GO:0006468protein phosphorylation
GO:0001503ossification
GO:0001525angiogenesis
GO:0006417regulation of translation
GO:0006983ER overload response
GO:0006986response to unfolded protein
GO:0010575positive regulation of vascular endothelial growth factor production
GO:0010628positive regulation of gene expression
GO:0016310phosphorylation
GO:0030968endoplasmic reticulum unfolded protein response
GO:0031018endocrine pancreas development
GO:0032055negative regulation of translation in response to stress
GO:0034198cellular response to amino acid starvation
GO:0034976response to endoplasmic reticulum stress
GO:0036492eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0042149cellular response to glucose starvation
GO:0045943positive regulation of transcription from RNA polymerase I promoter
GO:0046777protein autophosphorylation
GO:0051260protein homooligomerization
GO:0060734regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0070417cellular response to cold
GO:1902235regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990737response to manganese-induced endoplasmic reticulum stress
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0003116parenchymal cell
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR027295Quinoprotein_ADH-like_fam
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR011047Quinoprotein_ADH-like_supfam
Vocabulary: cellular component
TermDefinition
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0048471perinuclear region of cytoplasm