Phosphatidylinositol 3-kinase regulatory subunit alpha

Overview


Name	Phosphatidylinositol 3-kinase regulatory subunit alpha
Smed ID	SMED30006764
Length (bp)	3287

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Phosphatidylinositol 3-kinase regulatory subunit alpha (SMED30006764) t-SNE clustered cells

Violin plots show distribution of expression levels for Phosphatidylinositol 3-kinase regulatory subunit alpha (SMED30006764) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Phosphatidylinositol 3-kinase regulatory subunit alpha (SMED30006764) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30006764

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30006764	SMESG000078199.1	PL08004B1D03	ncbi_smed_ests	PMID:23079596 Forsthoefel et al., 2012
pharynx	SMED30006764	SMESG000078199.1	dd_Smed_v4_4794_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30006764	SMESG000078199.1	dd_Smed_v4_4794_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30006764	SMESG000078199.1	dd_Smed_v4_4794_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermal cell	SMED30006764	SMESG000078199.1	dd_Smed_v4_4794_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30006764	SMESG000078199.1	dd_Smed_v6_4794_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
epidermis	SMED30006764	SMESG000078199.1	dd_Smed_v4_4794_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8979])

HSP 1 Score: 188.734 bits (478), Expect = 3.781e-49
Identity = 161/594 (27.10%), Postives = 274/594 (46.13%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL---DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y  +I S+  + +      Q+   L    S+P     TL+YL++HF  + ++ +K  L ++  S IFS  L          F+A  S +   +  + E            L+S    +   + ++         +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPAAVYSEMI-SLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLF--------RFSAASSDNTENLIKVIEI-----------LISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

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Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL---DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y  +I S+  + +      Q+   L    S+P     TL+YL++HF  + ++ +K  L ++  S IFS  L          F+A  S +   +  + E            L+S    +   + ++         +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPAAVYSEMI-SLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLF--------RFSAASSDNTENLIKVIEI-----------LISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8979])

HSP 1 Score: 176.022 bits (445), Expect = 5.238e-47
Identity = 132/451 (29.27%), Postives = 219/451 (48.56%), Query Frame = 3

Query: 1833 IALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK + +      ++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQD------QVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 418

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8979])

HSP 1 Score: 175.637 bits (444), Expect = 1.321e-46
Identity = 131/450 (29.11%), Postives = 217/450 (48.22%), Query Frame = 3

Query: 1833 IALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK + +     + +     E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   47 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNI-----EAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 448

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
Match: PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981])

HSP 1 Score: 167.933 bits (424), Expect = 6.290e-44
Identity = 127/441 (28.80%), Postives = 211/441 (47.85%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLE-NVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKC 3146
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y    L++YN +L++ L YP S+ +       ++L +  N + + + L    S   E + + D+  E Y    +E+          +E  KI +     Q   +K   +      + +  + +  + D L+    +++D  ++  E + + + L  ++ E+ +K+   +PDL +L +++ Q +     + V  +  ++   + N DA      ++E+E+   Y                      +  WF+E+I R ++E+LL  +  G FLIR S + G YA  V  +G V+HC I+     YGF +    + SL++LV  +   SL  HN SL   LAYPV  
Sbjct:   60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ------DQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDS-KMRLEQDLKNQAL--DNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYD---------------------EKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHA 454

HSP 2 Score: 52.373 bits (124), Expect = 3.669e-6
Identity = 35/124 (28.23%), Postives = 57/124 (45.97%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEV 2231
            + + W+  + ++ +  D + G  DG FL+R+SS K  G Y  ++                  +GE K   I      YGF EP   + S+ +L+ +YQ   L ++ND LN+ L YP     P +
Sbjct:  354 DEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK--GCYACSVVA----------------DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSL 459

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
Match: aap-1 (Phosphoinositide 3-kinase adapter subunit; Phosphoinositide kinase AdAPter subunit [Source:UniProtKB/TrEMBL;Acc:G5EDP9])

HSP 1 Score: 63.5438 bits (153), Expect = 5.127e-10
Identity = 35/123 (28.46%), Postives = 63/123 (51.22%), Query Frame = 3

Query: 1848 INNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQ-EPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCS 2213
            + + +  Q WYW +  +  V+  ++   DG F+VR++S    G YTL+++                     KL+RI+ +DG  GF  +    +SV +LI++++   L+ +ND L++ L YP S
Sbjct:   11 VTHSLMEQGWYWADADRSAVSKALSDQPDGSFIVRNASTP--GDYTLSVKFAAQV----------------KLLRIVVKDGKCGFNTDSLTHDSVVRLIEFHRNISLNIFNDALDVRLLYPVS 115

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Query: 1848 INNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQ-EPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCS 2213
            + + +  Q WYW +  +  V+  ++   DG F+VR++S    G YTL+++                     KL+RI+ +DG  GF  +    +SV +LI++++   L+ +ND L++ L YP S
Sbjct:   11 VTHSLMEQGWYWADADRSAVSKALSDQPDGSFIVRNASTP--GDYTLSVKFAAQV----------------KLLRIVVKDGKCGFNTDSLTHDSVVRLIEFHRNISLNIFNDALDVRLLYPVS 115

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
Match: chin-1 (CHImaeriN (Rac-GTPase-activating protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q965N4])

HSP 1 Score: 58.5362 bits (140), Expect = 1.428e-8
Identity = 60/240 (25.00%), Postives = 109/240 (45.42%), Query Frame = 3

Query:  939 HKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNL-DLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLI----ESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTL 1643
            H     +F     CDYC   + GL  QG+ C  CG   HK C+ +  L  C   +P+  + +   +FGV++  L   H   +P  +  CI E++ R L+     ++  +Y +         LK+ F   ++ + + +  I  +       L+KLY + LP+ LI + ++  L+    E+ ++   ++    QI  ++  L   NI TL  ++ H   + +   K K+  +  + IFS TL
Sbjct:  172 HNFTSYTFKAPHYCDYCRNFLWGLVHQGMRCEDCGFAAHKKCS-EKTLHDC---VPD--SKYVKRMFGVDITTLCMAHGADLPPIVPLCIGEVESRGLDVEGIYRVSGSYDHMEK------LKQQFDSNQYVDLATVCDIHTV-----CGLLKLYFRLLPQQLIPFSVHKQLLVAYQETNQRSTHERE--RQIRKVMMELSDANIITLGAVLAHLKKVADHSAKNKMTVENLATIFSPTL 392

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
Match: spv-1 (Spermathecal Physiology Variant [Source:UniProtKB/TrEMBL;Acc:G5ECK6])

HSP 1 Score: 54.299 bits (129), Expect = 4.656e-7
Identity = 65/239 (27.20%), Postives = 104/239 (43.51%), Query Frame = 3

Query:  978 CDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNG-VPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCS--------------QIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIW 1649
            C  C+ + I      V CI CG  +HK C  +I  Q+C +    V     +SIFGV L     H N  +PL I+  ID+LQ R      G +    Y      +    +   F     D+E   V + + N + LA ++KLYL++LPEPL+ + +Y   +    +      CCS              Q+  +   LP  N ETL++++ H + +        + +   S + + +LIW
Sbjct:   92 CSACDTLSILYT---VQCIDCGGQWHKACFPRIQ-QVCGQAAKLVDR--RTSIFGVPLKGLLEHQNRHIPLIIEKSIDQLQRR------GLRAKGIYRTCGVKSKIEEICNAFERSSSDDE---VCLDNENPMNLASVVKLYLRKLPEPLLTFELYDDFVRLGTE------CCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTSNLSTVIAPSLIW 309

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
Match: spv-1 (Spermathecal Physiology Variant [Source:UniProtKB/TrEMBL;Acc:G5ECK6])

HSP 1 Score: 53.9138 bits (128), Expect = 5.060e-7
Identity = 65/239 (27.20%), Postives = 104/239 (43.51%), Query Frame = 3

Query:  978 CDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNG-VPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCS--------------QIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIW 1649
            C  C+ + I      V CI CG  +HK C  +I  Q+C +    V     +SIFGV L     H N  +PL I+  ID+LQ R      G +    Y      +    +   F     D+E   V + + N + LA ++KLYL++LPEPL+ + +Y   +    +      CCS              Q+  +   LP  N ETL++++ H + +        + +   S + + +LIW
Sbjct:  130 CSACDTLSILYT---VQCIDCGGQWHKACFPRIQ-QVCGQAAKLVDR--RTSIFGVPLKGLLEHQNRHIPLIIEKSIDQLQRR------GLRAKGIYRTCGVKSKIEEICNAFERSSSDDE---VCLDNENPMNLASVVKLYLRKLPEPLLTFELYDDFVRLGTE------CCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTSNLSTVIAPSLIW 347

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Match: Pi3K21B (gene:FBgn0020622 transcript:FBtr0331208)

HSP 1 Score: 115.546 bits (288), Expect = 1.537e-26
Identity = 120/451 (26.61%), Postives = 198/451 (43.90%), Query Frame = 3

Query: 1875 WYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLK--PEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEIT---KILKGIDQI---QTWCNKHIFQIMNIINSNE------------RTDWVSHSRDCLQQLNK---KLNDCVQVAKEM------NERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            WYWG  S+EE    + G  DG FLVRD+     G YTLT+                 K+G  KL++I   D  YGF E   F SV ++I YY+ + LS YN  L+I L  P  + +   E + H  +L   +NE  IR    T   +  +   ++    ++N  ++EL E      +    ++I   Q   N+   +      S E                 +++R  LQ+  +    L D +Q   ++      N+++E+L+     L R++   +P+L+ L   + + I   K   + D+   +      D   ++ E+  N+  ++ +L+ +K    R A                       EE+LK    GTFLI R+R+ G+YAL +    +VQHC I+  +  +GF      + +L+ LV+ +   SL  HN +LTT L +PV
Sbjct:   22 WYWGRISREEAKSILHGKPDGSFLVRDALSMK-GEYTLTLM----------------KDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPH-GDLCLLSNE-FIR----TCQLLQNLEQNLENKRNSFNAIREELQEKKLHQSVFGNTEKIFRNQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVLNHYMENKKKEELL-----LERQINALKPELQILQLRKDKYIERLKGFNLKDDDLKMILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNA-----------------------EEMLKGAPSGTFLI-RARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Match: Pi3K21B (gene:FBgn0020622 transcript:FBtr0331205)

HSP 1 Score: 115.546 bits (288), Expect = 1.537e-26
Identity = 120/451 (26.61%), Postives = 198/451 (43.90%), Query Frame = 3

Query: 1875 WYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLK--PEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEIT---KILKGIDQI---QTWCNKHIFQIMNIINSNE------------RTDWVSHSRDCLQQLNK---KLNDCVQVAKEM------NERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            WYWG  S+EE    + G  DG FLVRD+     G YTLT+                 K+G  KL++I   D  YGF E   F SV ++I YY+ + LS YN  L+I L  P  + +   E + H  +L   +NE  IR    T   +  +   ++    ++N  ++EL E      +    ++I   Q   N+   +      S E                 +++R  LQ+  +    L D +Q   ++      N+++E+L+     L R++   +P+L+ L   + + I   K   + D+   +      D   ++ E+  N+  ++ +L+ +K    R A                       EE+LK    GTFLI R+R+ G+YAL +    +VQHC I+  +  +GF      + +L+ LV+ +   SL  HN +LTT L +PV
Sbjct:   22 WYWGRISREEAKSILHGKPDGSFLVRDALSMK-GEYTLTLM----------------KDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPH-GDLCLLSNE-FIR----TCQLLQNLEQNLENKRNSFNAIREELQEKKLHQSVFGNTEKIFRNQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVLNHYMENKKKEELL-----LERQINALKPELQILQLRKDKYIERLKGFNLKDDDLKMILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNA-----------------------EEMLKGAPSGTFLI-RARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 420

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Match: Pi3K21B (gene:FBgn0020622 transcript:FBtr0331206)

HSP 1 Score: 78.1814 bits (191), Expect = 6.763e-16
Identity = 37/95 (38.95%), Postives = 58/95 (61.05%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            W +++ +R  +EE+LK    GTFLIR +R+ G+YAL +    +VQHC I+  +  +GF      + +L+ LV+ +   SL  HN +LTT L +PV
Sbjct:   28 WLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 121

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Match: Pi3K21B (gene:FBgn0020622 transcript:FBtr0331207)

HSP 1 Score: 78.1814 bits (191), Expect = 6.763e-16
Identity = 37/95 (38.95%), Postives = 58/95 (61.05%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            W +++ +R  +EE+LK    GTFLIR +R+ G+YAL +    +VQHC I+  +  +GF      + +L+ LV+ +   SL  HN +LTT L +PV
Sbjct:   28 WLLKDAKRRNAEEMLKGAPSGTFLIR-ARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPV 121

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Match: RhoGAP5A (gene:FBgn0029778 transcript:FBtr0070785)

HSP 1 Score: 58.151 bits (139), Expect = 3.451e-8
Identity = 58/245 (23.67%), Postives = 109/245 (44.49%), Query Frame = 3

Query:  939 HKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVK--KDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMV 1667
            H  +  +F G   C++C   + G   QGV C  CG   H  C+ ++    C  ++  +  VF + +  + + L+  H   +P  ++ C++E++ R      G      Y  +   ++   LK   A  R  E++++      N   +A  +KLYL+ LP PLI +  Y S + + +  K  E +   ++    +  LP  +   L+Y+++H   +       K+     + +F+ TLI  PQ M 
Sbjct:  242 HHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCS-ELVPPKCVPDLKRIRGVFGTDLTTM-VQLEPHHQ--IPFVVRRCVEEVEAR------GMLQEGIYRVSGFADEIEALK--LALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAE---AVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMT 471

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Zebrafish
Match: pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-030131-1280])

HSP 1 Score: 187.578 bits (475), Expect = 7.175e-49
Identity = 164/600 (27.33%), Postives = 278/600 (46.33%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDS---LPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSR---HQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P+P+I   IY+ +I  + ++ +    C+Q   ++ S   LP     TL+ L++HF  + +S     L ++  + IFS      P +   + T+ +     H RII+++   +        W     S+ Q + +      +   +       N  +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+T  L++YN +L++ L YP SK +       +++ +  N E + + LH       E N + D+  E Y    +E+          +E  KI +  +Q QT   +  ++I +     N  E    +       ++L  ++++ V   + + E  +K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N D    ++E DE+   +D                       + +W + NI R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PQPVIPPVIYNEMIR-IAQEVQGTDECAQHLRLVASSTALPPQYWLTLQSLLRHFSHVCQSSAVNLLSARALAEIFS------PALFRHQPTSCEPSPEAHIRIIEVLVTSE--------W-----SDSQAAPALPPKPPKPTSVANNGMNNNMALQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRTESLAQYNPKLDVKLLYPVSKHQQ------DQVVKEDNIEAVGKKLHEYHQQFQEKNREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKEYIEKFRREGNEKE----IQRIMVNYEKLKSRISEIVDSKRRLEEDLKKQAADYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGIKN-ENQDDQYSMVEDDEDLPHHD-----------------------ERSWKLGNINRIQAEALLRGKRDGTFLVRDSSKAGCYACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVTLAYPV 721

[Close]

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDS---LPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSR---HQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P+P+I   IY+ +I  + ++ +    C+Q   ++ S   LP     TL+ L++HF  + +S     L ++  + IFS      P +   + T+ +     H RII+++   +        W     S+ Q + +      +   +       N  +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+T  L++YN +L++ L YP SK +       +++ +  N E + + LH       E N + D+  E Y    +E+          +E  KI +  +Q QT   +  ++I +     N  E    +       ++L  ++++ V   + + E  +K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N D    ++E DE+   +D                       + +W + NI R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PQPVIPPVIYNEMIR-IAQEVQGTDECAQHLRLVASSTALPPQYWLTLQSLLRHFSHVCQSSAVNLLSARALAEIFS------PALFRHQPTSCEPSPEAHIRIIEVLVTSE--------W-----SDSQAAPALPPKPPKPTSVANNGMNNNMALQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRTESLAQYNPKLDVKLLYPVSKHQQ------DQVVKEDNIEAVGKKLHEYHQQFQEKNREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKEYIEKFRREGNEKE----IQRIMVNYEKLKSRISEIVDSKRRLEEDLKKQAADYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGIKN-ENQDDQYSMVEDDEDLPHHD-----------------------ERSWKLGNINRIQAEALLRGKRDGTFLVRDSSKAGCYACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVTLAYPV 721

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Zebrafish
Match: pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-030131-1280])

HSP 1 Score: 176.022 bits (445), Expect = 6.140e-47
Identity = 133/445 (29.89%), Postives = 215/445 (48.31%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+T  L++YN +L++ L YP SK +       +++ +  N E + + LH       E N + D+  E Y    +E+          +E  KI +  +Q QT   +  ++I +     N  E    +       ++L  ++++ V   + + E  +K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N D    ++E DE+   +D                       + +W + NI R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   51 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRTESLAQYNPKLDVKLLYPVSKHQQ------DQVVKEDNIEAVGKKLHEYHQQFQEKNREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKEYIEKFRREGNEKE----IQRIMVNYEKLKSRISEIVDSKRRLEEDLKKQAADYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGIKN-ENQDDQYSMVEDDEDLPHHD-----------------------ERSWKLGNINRIQAEALLRGKRDGTFLVRDSSKAGCYACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVTLAYPV 443

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Zebrafish
Match: pik3r3b (phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [Source:ZFIN;Acc:ZDB-GENE-040426-743])

HSP 1 Score: 172.94 bits (437), Expect = 9.477e-46
Identity = 143/465 (30.75%), Postives = 212/465 (45.59%), Query Frame = 3

Query: 1842 EEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELD----EITKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELH---------------------RKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            E  +  +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+              Y  + L++       +I  V  K+ +    Y E  KE D    E TK  + I   +T     N+ I       ++ ER     +S++ +++  ++ ND       MN   EKL +   E+H                     +K+   +PDL +L +++ Q +     + V     ++   L+N    DA   + E DEN        Y  KS                  WF+ ++ RT+SE+LL  +  G FLIR S + G YA  V V G V+HC I+     +GF +    + +L+DLV  +H  SL  HN SL   LAYPV
Sbjct:   56 EAASGSLQEAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYRHESLAQYNTKLDVKLMYPVSR--------------YQQDQLVK-----EDNIDAVGRKLQEYHNQYQEKSKEYDRLYEEHTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKEYIERFRREGNDKEIERIMMN--YEKLKSRLGEIHDSKTRLEQDLKTQALDNRETDKKMNSLKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGLKNETTDDAYF-VSEEDEN-----LPHYDEKS------------------WFVGDLNRTQSEDLLHGKPDGAFLIRESSKKGCYACSVVVEGEVKHCVIYSTPRGFGFAEPYNLYSTLKDLVLHYHQTSLVQHNDSLNVRLAYPV 454

[Close]

Query: 1842 EEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELD----EITKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELH---------------------RKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            E  +  +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+              Y  + L++       +I  V  K+ +    Y E  KE D    E TK  + I   +T     N+ I       ++ ER     +S++ +++  ++ ND       MN   EKL +   E+H                     +K+   +PDL +L +++ Q +     + V     ++   L+N    DA   + E DEN        Y  KS                  WF+ ++ RT+SE+LL  +  G FLIR S + G YA  V V G V+HC I+     +GF +    + +L+DLV  +H  SL  HN SL   LAYPV
Sbjct:   56 EAASGSLQEAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYRHESLAQYNTKLDVKLMYPVSR--------------YQQDQLVK-----EDNIDAVGRKLQEYHNQYQEKSKEYDRLYEEHTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKEYIERFRREGNDKEIERIMMN--YEKLKSRLGEIHDSKTRLEQDLKTQALDNRETDKKMNSLKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGLKNETTDDAYF-VSEEDEN-----LPHYDEKS------------------WFVGDLNRTQSEDLLHGKPDGAFLIRESSKKGCYACSVVVEGEVKHCVIYSTPRGFGFAEPYNLYSTLKDLVLHYHQTSLVQHNDSLNVRLAYPV 454

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:100486835])

HSP 1 Score: 174.481 bits (441), Expect = 1.394e-44
Identity = 156/589 (26.49%), Postives = 264/589 (44.82%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL--DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKL-VLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y  ++ + ++          +   +   ++P     TL+YL++HF  + +S +K  L +K  + IFS      P +   + + L   H  +  L+ E  L  L+ + T P       + +   +   N +  LQ A           EWYWG+ S+EEVN+ +    DG FLVRD+S    G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK + +     + +     E + + L        E N + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ +   +L  ++++ V   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +           E L S+  ED+  YS+ + +    +           +  W + NI R ++E LL+ ++ GTFL+R S + G YA  V  +G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LA PV
Sbjct:  174 PNPVIPALMYSEMLSAARESISSDEYVQLLRKTIRCANVPQQYWLTLQYLLKHFLQLCQSSSKNLLSAKSLAEIFS------PLLFRIQASILHGGHY-VQDLVIESMLGFLVVQQTLP---PKPPKSTAVTNNGTNHIMSLQDA-----------EWYWGDISREEVNEKLRDTTDGTFLVRDASTIMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELITHYRNESLAQYNPKLDVKLLYPVSKFQQDQLVKEDSI-----EAVGKKLREYNVQFEEKNQEYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQEKYSKEYIEKFRREGNEKEIQRILHNHE---KLKSRISEIVDSKRRLEEDLKKQTAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLN-----------EWLGSENTEDQ--YSVVEDEDLPHQD----------ERTWNVGNINRNQAENLLRGKRDGTFLVRESSKAGCYACSVVADGEVKHCVINKTLTGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLANPV 694

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Match: hvcn1 (hydrogen voltage gated channel 1 [Source:Xenbase;Acc:XB-GENE-955585])

HSP 1 Score: 168.703 bits (426), Expect = 1.534e-44
Identity = 125/442 (28.28%), Postives = 210/442 (47.51%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  +DG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+ + +      +L +  N + + R L        + + + DK  E Y +  +E+          +E  KI +     Q   +K   +  N   + +  + +  +    ++L  +L +       + +  +K   ++ E+ +K+   +PDL +L +++ Q +     + V     ++   ++N +NID    + E D+N    D                       +  WF+ ++ R ++EELL  +  G FLIR S + G YA  V  +G V+HC I+  +  YGF +    + +L++LV  +   SL  HN SL   LAYPV
Sbjct:   23 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLTLR----------------KGGNNKLIKIYHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQD------QLVKEDNIDAVGRKLQEYHGQFQDKSKEYDKLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQERYSKEYMERFNREGNEKEMERIIMN---YEKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENIDDTYFVSEEDDNLPHYD-----------------------EKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKKGCYACSVVADGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPV 415

HSP 2 Score: 52.373 bits (124), Expect = 3.587e-6
Identity = 33/120 (27.50%), Postives = 57/120 (47.50%), Query Frame = 3

Query: 1875 WYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEV 2231
            W+ G+ ++ +  + ++G  DG FL+R+SS K  G Y  ++                  +G+ K   I      YGF EP   + ++ +L+ +YQ   L ++ND LN+ L YP     P +
Sbjct:  321 WFVGDLNRIQAEELLSGKPDGAFLIRESSKK--GCYACSVVA----------------DGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPVYAQMPSL 422

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Match: hvcn1 (hydrogen voltage gated channel 1 [Source:Xenbase;Acc:XB-GENE-955585])

HSP 1 Score: 169.088 bits (427), Expect = 2.031e-44
Identity = 125/442 (28.28%), Postives = 210/442 (47.51%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  +DG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+ + +      +L +  N + + R L        + + + DK  E Y +  +E+          +E  KI +     Q   +K   +  N   + +  + +  +    ++L  +L +       + +  +K   ++ E+ +K+   +PDL +L +++ Q +     + V     ++   ++N +NID    + E D+N    D                       +  WF+ ++ R ++EELL  +  G FLIR S + G YA  V  +G V+HC I+  +  YGF +    + +L++LV  +   SL  HN SL   LAYPV
Sbjct:   43 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLTLR----------------KGGNNKLIKIYHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQD------QLVKEDNIDAVGRKLQEYHGQFQDKSKEYDKLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQERYSKEYMERFNREGNEKEMERIIMN---YEKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENIDDTYFVSEEDDNLPHYD-----------------------EKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKKGCYACSVVADGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPV 435

HSP 2 Score: 52.373 bits (124), Expect = 3.516e-6
Identity = 33/124 (26.61%), Postives = 59/124 (47.58%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEV 2231
            + + W+ G+ ++ +  + ++G  DG FL+R+SS K  G Y  ++                  +G+ K   I      YGF EP   + ++ +L+ +YQ   L ++ND LN+ L YP     P +
Sbjct:  337 DEKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKK--GCYACSVVA----------------DGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPVYAQMPSL 442

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Match: hvcn1 (hydrogen voltage gated channel 1 [Source:Xenbase;Acc:XB-GENE-955585])

HSP 1 Score: 169.088 bits (427), Expect = 2.057e-44
Identity = 125/442 (28.28%), Postives = 210/442 (47.51%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  +DG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+ + +      +L +  N + + R L        + + + DK  E Y +  +E+          +E  KI +     Q   +K   +  N   + +  + +  +    ++L  +L +       + +  +K   ++ E+ +K+   +PDL +L +++ Q +     + V     ++   ++N +NID    + E D+N    D                       +  WF+ ++ R ++EELL  +  G FLIR S + G YA  V  +G V+HC I+  +  YGF +    + +L++LV  +   SL  HN SL   LAYPV
Sbjct:   57 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLTLR----------------KGGNNKLIKIYHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQD------QLVKEDNIDAVGRKLQEYHGQFQDKSKEYDKLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQERYSKEYMERFNREGNEKEMERIIMN---YEKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENIDDTYFVSEEDDNLPHYD-----------------------EKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKKGCYACSVVADGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPV 449

HSP 2 Score: 52.373 bits (124), Expect = 3.455e-6
Identity = 33/124 (26.61%), Postives = 59/124 (47.58%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEV 2231
            + + W+ G+ ++ +  + ++G  DG FL+R+SS K  G Y  ++                  +G+ K   I      YGF EP   + ++ +L+ +YQ   L ++ND LN+ L YP     P +
Sbjct:  351 DEKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKK--GCYACSVVA----------------DGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPVYAQMPSL 456

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Match: hvcn1 (hydrogen voltage gated channel 1 [Source:Xenbase;Acc:XB-GENE-955585])

HSP 1 Score: 168.703 bits (426), Expect = 2.227e-44
Identity = 125/442 (28.28%), Postives = 210/442 (47.51%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  +DG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+ +       ++L +  N + + R L        + + + DK  E Y +  +E+          +E  KI +     Q   +K   +  N   + +  + +  +    ++L  +L +       + +  +K   ++ E+ +K+   +PDL +L +++ Q +     + V     ++   ++N +NID    + E D+N    D                       +  WF+ ++ R ++EELL  +  G FLIR S + G YA  V  +G V+HC I+  +  YGF +    + +L++LV  +   SL  HN SL   LAYPV
Sbjct:   47 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLTLR----------------KGGNNKLIKIYHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQ------DQLVKEDNIDAVGRKLQEYHGQFQDKSKEYDKLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQERYSKEYMERFNREGNEKEMERIIMN---YEKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENIDDTYFVSEEDDNLPHYD-----------------------EKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKKGCYACSVVADGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPV 439

HSP 2 Score: 52.373 bits (124), Expect = 3.482e-6
Identity = 33/124 (26.61%), Postives = 59/124 (47.58%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEV 2231
            + + W+ G+ ++ +  + ++G  DG FL+R+SS K  G Y  ++                  +G+ K   I      YGF EP   + ++ +L+ +YQ   L ++ND LN+ L YP     P +
Sbjct:  341 DEKTWFVGDLNRIQAEELLSGKPDGAFLIRESSKK--GCYACSVVA----------------DGDVKHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQHNDSLNVRLAYPVYAQMPSL 446

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Match: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:MGI Symbol;Acc:MGI:97583])

HSP 1 Score: 191.43 bits (485), Expect = 3.770e-50
Identity = 163/594 (27.44%), Postives = 274/594 (46.13%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIE-----TLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y+ ++ S+ ++ +    C Q+   L  LP  NI      TL+YL++HF  + ++ +K  L ++  S IFS  L   P        A     + +I+ I     +LI    W     +E Q + +      +   +       N  +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPVAVYNEMM-SLAQELQSPEDCIQLLKKLIRLP--NIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFP-------AASSDNTEHLIKAI----EILIST-EW-----NERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Match: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:MGI Symbol;Acc:MGI:97583])

HSP 1 Score: 174.481 bits (441), Expect = 2.467e-46
Identity = 128/440 (29.09%), Postives = 211/440 (47.95%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   58 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 448

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Match: Pik3r3 (phosphoinositide-3-kinase regulatory subunit 3 [Source:MGI Symbol;Acc:MGI:109277])

HSP 1 Score: 170.629 bits (431), Expect = 5.763e-45
Identity = 132/444 (29.73%), Postives = 211/444 (47.52%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKC 3146
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF EP  F SV +LI +Y    L++YN +L++ L YP S+ +       ++L +  N + + + L    S   E + + D+  E Y    +E+          +E  KI +     Q   +K   +      + +  + +  + D L+    +++D  ++  E + +++ L  ++ E+ +K+   +PDL +L +++ Q +     R V     +    ++N D+ D    I E DEN    D                       +  WF+E+I R ++E+LL  +  G FLIR S + G YA  V  +G V+HC I+     YGF +    + SL++LV  +   SL  HN SL   LAYPV  
Sbjct:   60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQQ------DQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDS-KLRLEQDLKKQAL--DNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKNEDS-DESYFINEEDENLPHYD-----------------------EKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHA 454

HSP 2 Score: 52.7582 bits (125), Expect = 2.252e-6
Identity = 35/122 (28.69%), Postives = 56/122 (45.90%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKP 2225
            + + W+  + ++ +  D + G  DG FL+R+SS K  G Y  ++                  +GE K   I      YGF EP   + S+ +L+ +YQ   L ++ND LN+ L YP     P
Sbjct:  354 DEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK--GCYACSVVA----------------DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 457

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Match: Gm49337 (predicted gene, 49337 [Source:MGI Symbol;Acc:MGI:6121526])

HSP 1 Score: 170.244 bits (430), Expect = 1.876e-44
Identity = 131/442 (29.64%), Postives = 206/442 (46.61%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF EP  F SV +LI +Y    L++YN +L++ L YP S+ +       ++L +  N + + + L    S   E + + D+  E Y    +E+          +E  KI +     Q   +K   +      + +  + +  + D   +L  +L +       + +  +K   ++ E+ +K+   +PDL +L +++ Q +     R V     +    ++N D+ D    I E DEN    D                       +  WF+E+I R ++E+LL  +  G FLIR S + G YA  V  +G V+HC I+     YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  101 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQ------QDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYD---KLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKNEDS-DESYFINEEDENLPHYD-----------------------EKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 493

HSP 2 Score: 52.373 bits (124), Expect = 2.753e-6
Identity = 35/122 (28.69%), Postives = 56/122 (45.90%), Query Frame = 3

Query: 1863 NSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCK-FESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKP 2225
            + + W+  + ++ +  D + G  DG FL+R+SS K  G Y  ++                  +GE K   I      YGF EP   + S+ +L+ +YQ   L ++ND LN+ L YP     P
Sbjct:  395 DEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK--GCYACSVVA----------------DGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 498

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Match: Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2 [Source:MGI Symbol;Acc:MGI:1098772])

HSP 1 Score: 166.392 bits (420), Expect = 5.204e-42
Identity = 126/440 (28.64%), Postives = 211/440 (47.95%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNK-HIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKC 3146
            +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL+++  RDG YGF EP  F SV +LI +Y+   L++YN +L+  L YP SK + +    V E         +++ H    D +    + D+  E Y    +EL          +E  KI +   Q Q  C+K ++ +     N  E    + +S    ++L  ++ +  +   ++ +      +++ E+ +++   +PDL +L +++ Q +     +              I+    I    +NE ++ YSL + +            P + +  W++  I RT++EE+L  ++ GTFLIR S + G YA  V V+G  +HC I+     +GF +    + SL++LV  +   SL  HN +LT  LA+PV+ 
Sbjct:  319 LQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLR----------------KGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQV--VKEDSIEAVGAQLKVYHQQYQDKSR---EYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNS----ERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGA--------RQRKINEWLGI----KNETEDQYSLMEDEDA---------LPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRA 712

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Match: sp|P26450|P85A_MOUSE (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Mus musculus OX=10090 GN=Pik3r1 PE=1 SV=2)

HSP 1 Score: 191.43 bits (485), Expect = 2.637e-49
Identity = 163/594 (27.44%), Postives = 274/594 (46.13%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIE-----TLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y+ ++ S+ ++ +    C Q+   L  LP  NI      TL+YL++HF  + ++ +K  L ++  S IFS  L   P        A     + +I+ I     +LI    W     +E Q + +      +   +       N  +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPVAVYNEMM-SLAQELQSPEDCIQLLKKLIRLP--NIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFP-------AASSDNTEHLIKAI----EILIST-EW-----NERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Match: sp|Q5R685|P85A_PONAB (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Pongo abelii OX=9601 GN=PIK3R1 PE=2 SV=1)

HSP 1 Score: 189.119 bits (479), Expect = 1.380e-48
Identity = 161/594 (27.10%), Postives = 275/594 (46.30%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL---DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y  +I S+ ++ +      Q+   L    S+P     TL+YL++HF  + ++ +K  L ++  S IFS  L          F+A  S +   +  + E            L+S    +   + ++         +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPAAVYSEMI-SLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLF--------RFSAASSDNTENLIKVIEI-----------LISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Match: sp|P27986|P85A_HUMAN (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2)

HSP 1 Score: 188.734 bits (478), Expect = 1.816e-48
Identity = 161/594 (27.10%), Postives = 274/594 (46.13%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL---DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y  +I S+  + +      Q+   L    S+P     TL+YL++HF  + ++ +K  L ++  S IFS  L          F+A  S +   +  + E            L+S    +   + ++         +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPAAVYSEMI-SLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLF--------RFSAASSDNTENLIKVIEI-----------LISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Match: sp|Q63787|P85A_RAT (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Rattus norvegicus OX=10116 GN=Pik3r1 PE=1 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 6.302e-47
Identity = 158/594 (26.60%), Postives = 271/594 (45.62%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIE-----TLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +Y+ ++ S+ ++        Q+   L  + SPNI      TL+YL++HF  + ++ +K  L ++  S IFS  L   P        A     + +I+ +      L+    W     SE Q + +      +   +       N  +   EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          ++  KI +     Q   +K   +      + +    + H+ D   +L  ++++ +   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    +++ DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPVAVYNEMM-SLAQEVPSSEDYIQLLKKL--IRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFP-------AASSDNTEHLIKAV-----ELLISAEW-----SERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNDTIKIFEEQCHPQERYSKDYIEKFKREGNEKEIQRIMHNHD---KLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVDDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Match: sp|P23727|P85A_BOVIN (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Bos taurus OX=9913 GN=PIK3R1 PE=1 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 7.094e-47
Identity = 161/594 (27.10%), Postives = 271/594 (45.62%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSIL---DSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQ--EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFS--LENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P P+I   +   LI S+  + +      Q+   L    S+P     TL+YL++HF  + ++ +K  L ++  S +FS  L          F A  S +   +  I E            L+S    +   + ++         +A   +NN+++ Q  EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + + LH   +   E + + D+  E Y    +E+          +E  KI +   Q Q   +K   +      +      + H+    ++L  ++++ V   + + E  +K   E  E+ +++   +PDL +L + + Q +     + V  +  +  L N +N +    ++E DE+   +D   + + S+N                       R ++E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  194 PNPVIPVAVSSELI-SLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSELFSPLLF--------RFPAASSENTEHLIKIIEI-----------LISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ------DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHN---YEKLKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN-ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN-----------------------RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Match: C3YA44 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_91712 PE=4 SV=1)

HSP 1 Score: 262.692 bits (670), Expect = 3.110e-69
Identity = 236/877 (26.91%), Postives = 406/877 (46.29%), Query Frame = 3

Query:  582 SDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSS---IFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTW----PLVSVSEEQMSLSQSMNKNQLGCL-QIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEI----TKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSR----------DCLQQLNKKLNDCVQVAKEMNERREKLITESDE-LHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALD-VNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            S WS E V  W+ +VN  R  +LF+ ++++G            +L+ L ++ A     I D F+R  L  +    ID    GT   +T   LD      ++H    S       + +++H+ +E SF+    CD C++ + GL +QG+ C  C  + H++CA    +  C   + +     + S   +FG +L LQ    +  P+ +  C   ++ R L+     ++    S TAA N+   LK+      F+ + N V +   +   ++  +K YL+ELP P++   +Y S I + K+  E+    +++  ++  LP  +  TL +L+ HF  + +     K+  K  +++F   L+ PP   V + T+    H ++++L       L+   +W    P V + E++ ++   M   + G        E    +   EWYWG+ S+EEVND +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF EP +F SV +LI++Y+   L++YN +L++ L YP SK+            Q  +EG+        S +  V  K+ +  + Y +  K+ D++    TK  + I Q++        + ++I     ++    HS           +  + L  +LN+ ++ +K++ E   KL TE +  L R++   +PD+ +L +++ Q +     + V             D + E L++  +    D +        +          +++S WF+ +  R  +E LL  +  GTFL+R+S +  NYAL  V   G  +HC I+     YGF +    + SL+DLV  +   SL  HN SL T LAYPV
Sbjct:  237 SRWSVENVQHWMAAVNLSRYSELFKARHVDGS-----------KLETL-NDQALMHMGIMDDFHRICLMNS----IDELCKGTSAMRTAVPLD-----PSSHGEEAS-------LPISSHRFKEHSFSTVTWCDKCHKFLWGLIRQGLQCQDCAYSCHRMCA-HTGVPPCNTEVRDRRRRESYSPNPLFGEDLKLQFSPPDPAPVVVIKCCKAIEERGLDLDGIYRIS---SSTAAINE---LKK-----SFNTDPNSVDLSIYDLHCVSGALKRYLRELPNPVLTTELYDSFIAAAKELKEEVELVARLLELVKQLPEQHRLTLEWLMAHFCRVCQHIKANKMTPKHLAVVFCHILMRPPWENVLQVTSNTEYHVKVVEL-------LLTGGSWGEALPDVELEEDKPAIPPRMPLGRKGKENSFNNYETPQSLQEAEWYWGDISREEVNDKLKDTPDGTFLVRDASTKYKGDYTLTLR----------------KGGNNKLIKICHRDGKYGFSEPLRFSSVVELIQHYRKESLAQYNCKLDVRLTYPVSKI------------QQGDEGV------EGSSVDMVGKKLQELNKEYLDKSKQYDQLYESYTKSTQEI-QMKRQALDAFKETISIFEEQAKSHERYHSEVKGQEYKKIMENYENLKSRLNEIIESSKQL-ELDLKLQTEGNRNLDREMNSIKPDIIQLRKIRDQYVMWLGHKGVKQ-----------DKINEWLKASYDGHGGDTTAPNFNEEALPH--------HDESLWFLPDCSRVHAESLLDGKPEGTFLVRKSSQQNNYALSIVAEEGAARHCVIYNSATGYGFAEPYNLYASLKDLVLHYQQNSLYEHNDSLNTTLAYPV 1011

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Match: A0A2P6K857 (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Nephila clavipes OX=2585209 GN=NCL1_48895 PE=4 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 8.089e-68
Identity = 241/885 (27.23%), Postives = 396/885 (44.75%), Query Frame = 3

Query:  579 LSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSG--SKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFN--SSIFGVNLDLQKLHS-NGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEF--TALKSRHQRIIQLIFEYK--------LVLIDKFTWPLV------SVSEEQMSL----------SQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            LS W++  V++W+ ++N +R  +LF++K+I G D+   M  D  +L N+          + D F+++ +               L C   D+   N+L ++ H+     + ++E       NH++ E SF+  + CD C+  + G+  QGV C +CG  +H+ CA    L  C  +     N  N  S+IFG +L  Q L S    PL +  CI E+++R    +N   L   Y  +A ++    L++     +  E+     +       +A  +K YL+ELP P+     Y   IE+ K    D  C   +  ++  LP  +  TL+ L+ HF      C   +LQ       +S+ +  PP I+++      L+   +RI+Q+++  +        L+L  K+  P+       ++   ++S           S SM+ N    +     E    +   EWYWG+ ++EEVN+ +    DG FLVRD+S+K  G YTLT+R                K G NKL++I  R+G YGF EP  F SV +LI YY    L++YN  L++ L +P S+  P+ K     LY    E   +    T  D+       D    T    ++++  +   LKG             +I  ++ + E                  L   +Q  +E  +  +  +      HR L       + +N L+ +I+RL+K RE    M   + V   D + ++L+    E ++      I+ +   Q  +   P +N+S WF+++I R E+  LL  +  GTFLIR SR  G YAL +  +G V HC I+  +  YGF +      SL+ LV  +   SL  HN +L T LAYPV
Sbjct:   12 LSQWTSSNVVEWMAALNLYRYAELFKSKDIKGSDL---MALDRDKLMNM---------GVKDEFHQKAI---------------LVC-VDDLCQRNNLNRSLHETKALNASLREGASPTGNNHQLLEQSFSCVLQCDKCHNYLHGVIHQGVVCQECGLIWHRTCA-ATGLPRCNSDNVEKANRKNLISAIFGKDLSCQFLPSVQSAPLLVIRCIFEIENRGAA-TNNIDLYRVYRTSAPSDIVAELRQ-----KLSEDVERTNLASYELHCIASALKKYLRELPNPVFPVQFYDKFIETAKIQNNDH-CVQALEQLVHQLPIHHKSTLQTLMAHF------CRVCRLQ-------YSRGIKEPPTILIQMLCHILLRPPWERIVQIVYNTEAHIRVVELLLLKGKWGEPMPVFDSAPALPPRRISKPFPESMLHGGSLSMSPNSAATIPQRPSEGPKSLADAEWYWGDITREEVNEKLKDTPDGTFLVRDASNKGSGEYTLTLR----------------KGGSNKLIKICQRNGKYGFTEPLMFNSVVELITYYHNVSLAQYNRTLDVKLLHPVSRFHPKTK-----LYDQFYEDYSK----TFQDVQLKKQAQDAFIATLAVFEEQIHLLEDNLKGAAPC---------EIQPLMENYEL-----------------LKSRLQALEESKKHLDMELKHQAAFHRSLD------REMNTLKPEIMRLYKQREDFQAMLYAKGVKK-DRVFKLLQDSCTEARDI-----IRESAFLQD-DETLPHHNESLWFLQDISRNEATRLLTGKPDGTFLIRNSRTQGQYALSIVADGKVGHCLIYKTDKGYGFAEPYNVHPSLKSLVLHYAQTSLEEHNDTLKTTLAYPV 783

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Match: A0A4Y2HHT6 (Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Araneus ventricosus OX=182803 GN=PIK3R1 PE=4 SV=1)

HSP 1 Score: 254.218 bits (648), Expect = 6.166e-67
Identity = 248/937 (26.47%), Postives = 423/937 (45.14%), Query Frame = 3

Query:  453 TSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNS--GSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFN--SSIFGVNLDLQKLHS-NGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEF--TALKSRHQRIIQLIFEYK--------LVLIDKFTWPLV------SVSEEQMS----------LSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEI----TKILKGIDQIQTWCNKHIFQIMNIINSNER--TDWVSHSRDC-LQQLNKK---LNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            T C   FH +C      F       +N+ +         E+ LS W++  V++W+ ++N +R  +LF++K+I G D+++           L+ +     G + D F+++    A+   +D            D+   N+L ++ H+     + ++E       NH++ E SF+  + CD C+  + G+  QGV C +CG  +H+ CA    L  C  +     N  N  S+IFG +L  Q L S    PL +  CI E++ R    +N   L   Y  +A ++    L++     +  E+     +       +A  +K YL+ELP P+     Y   IE+ K    D+ C   +  ++  LP  +  TL+ L+ HF      C   +LQ       +S+ +  PP I+++      L+   +RI+Q+++  +        L+L  K+  P+       ++   ++S          L  +M+ N    +     E    +   EWYWG+ ++EEVN+ +    DG FLVRD+S+K  G YTLT+R                K G NKL++I  R+G YGF EP  F SV +LI YY    L++YN  L++ L +P S+  P     ++E     +E +         D+ +V  K+ K  + Y +  K  D+     +K  + + Q++          + +         D +  +  C +Q L +    L   +Q  +E  ++ +  +      HR L       + +N L+ +I+RL+K RE    M   + V   D + ++L+   +E ++      I+ +   Q  +   P +N+S WF+++I R E+  LL  +  GTFLIR SR  G YAL +  +G V HC I+  +  YGF +      SL+ LV  +   SL  HN +L T LAYPV
Sbjct:   57 TECLGCFHDVC----VPFAPSHLCQRNSGEPPPNTLDR-EVPLSQWTSSNVVEWMAALNLYRYAELFKSKDIKGSDLMT-----------LDRDKLMSMG-VKDEFHQK----AILVCVD------------DLCQRNNLNRSLHETKTQNASLREGSSPTSNNHQLLEQSFSCVLQCDKCHNYLHGVIHQGVVCQECGLIWHRTCA-ATGLPRCNTDNIEKANRKNLISAIFGKDLSCQFLPSVQSAPLLVIRCILEIESRGAA-TNNIDLYRVYRTSAPSDIVAELRQ-----KLSEDVERTNLASYELHCIASALKKYLRELPNPVFPVQFYDKFIETAKIQNNDQ-CVQALEQLVHQLPIHHKSTLQTLMAHF------CRVCRLQ-------YSRGIKEPPTILIQMLCHILLRPPWERIVQIVYNTEAHIRVVELLLLKGKWGEPMPVFDSAPALPPRRISKINQPFPESVLHGNMSPNSGSTIPQRPSEGPKSLADAEWYWGDITREEVNEKLKDTPDGTFLVRDASNKGSGEYTLTLR----------------KGGSNKLIKICHRNGKYGFTEPLMFNSVVELINYYHNVSLAQYNRTLDVKLLHPVSRFHPT---GIDE-----DESI---------DVEKVGEKLMKINQEYLQKTKLYDQFYEDYSKTFQDV-QLKKQAQDAFVATLAVFEEQIHLLEDNLKGAAPCEIQPLMENYELLKSRLQALEESKKQLDMELKHQAAFHRSLD------REMNTLKPEIMRLYKQREDFQAMLYAKGVKK-DRVFKLLQDSCSEARD-----IIRESAFLQD-DETLPHHNESLWFLQDITRNEAIRLLTGKPDGTFLIRNSRTQGQYALSIVADGKVGHCLIYKTDKGYGFAEPYNVHPSLKSLVLHYAQTSLEEHNDTLKTTLAYPV 892

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Match: A0A0M3TCH6 (PI3K21B OS=Leptinotarsa decemlineata OX=7539 PE=2 SV=1)

HSP 1 Score: 249.98 bits (637), Expect = 2.966e-65
Identity = 253/937 (27.00%), Postives = 415/937 (44.29%), Query Frame = 3

Query:  387 TISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHD---NSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVF--NSSIFGVNLDLQ-KLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLI--WESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEY-----KLV-LIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDE----LHRKLQMDRPDLKRLNRLQAQIIRLFKDREV-PDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            T  LC  C + + G G   + C  C+  FH+ C +    +  CQK   N     V L    +  +S+W++  V++W+ ++N +   D+F  K+I G D++           NL+ +     G I D F+++ +   +  L+          K  D L +    ++ HD   NS S            H + + SF+    CD CN+ + GL  QG  C  CG   H+ CA    L  C     +  + F    S FG  L  Q KL  +  P  +  C  EL+ R    +   + ++ Y+   AT  +  L+ L    R +E SN V + + + + +A + K YL+ELP+PL+    Y   +E+ KK   D+ C S +  +++ LP  +  TLR+++ H   I   E     K        +     + PP   V +       H RI++L+  Y     KL         P   VS    S+  S+       L+   E+ N  +   EWYWG+  +E+VN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  R+G YGF EP  F SV +LI +++   LS+YN  L+I L YP S+   E +    E      E LI  ++  +++  +++  V K+   +NE   E+      L  + ++       +F+    I    + +   H    L+  ++ L   + +  E  E+ E+++ + +     L R+L   +P +  L R + + +R  + R   P ++  + N  NI+   E  + D +   ++   Y                      W + +  RTE+E+LL+ +  GTFL+R+SR++  YAL V  NG   HC I   +   GF +    + +L+DLV  +   SL  HN  L TVLAYP+
Sbjct:  108 TPILCKHCKDYIWGQGHVGVKCKDCHACFHNYCLRFFPGY-LCQK--DNDVLPPVTL--DYDKPISEWTSSNVIEWMAALNLYTYCDVFRCKDIKGADLI-----------NLDRDKLIGMG-IKDEFHQKAILSCIDELLK---------KPDDKLSM----RSEHDETLNSNSNYA---------HNLSQHSFSSLERCDKCNKYLRGLLHQGFICQDCGLVAHRTCA-ATGLPSCTHRPMDDRSHFIQFKSFFGQGLCCQFKLSDSPAPELLINCALELEKR----AKASESLELYNLYCATPPSDQLQLLVK--RIEENSNNVNLSEFSPVCIASVFKKYLRELPDPLVPVQWYDKFLEASKKR-NDEECTSILRQLVEELPDHHKSTLRFIMGHLCRICQLEYARGNKSPPTVLVQVMCHIFLRPPWERVIQVVYNTQAHNRIVELLLLYCDWGEKLPEFASAPAIPPRKVSRMGSSVYYSL-------LEREKEKNNMSLQDAEWYWGSIKREDVNEVLNDTVDGTFLVRDASSKC-GEYTLTLR----------------KGGANKLIKICHRNGMYGFTEPYTFHSVVELINHFRNDSLSQYNASLDIKLLYPVSRNNQEEELAKTEKIDKLVENLIN-INQNLAEKNKISETVSKD---FNETSTEVQTKRHALDALKELV-----QLFKDQTTIQEKSQNEAQPHEIKSLEINSELLKKRLNLMSESCEQLEEILKQKEAYKKVLERELTSLKPGIVGLARERDRYVRWLQQRGFSPAKINQILNT-NIEEPSEGCDVDTDTLPHNDERY----------------------WLMLDCSRTEAEKLLEGKPDGTFLVRKSRQMNKYALSVVCNGSTNHCIINETSKGLGFTEPYNIYPTLKDLVLHYATNSLEIHNDLLNTVLAYPI 941

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Match: A0A1Y1KD31 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_05851 PE=4 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 1.412e-64
Identity = 248/943 (26.30%), Postives = 415/943 (44.01%), Query Frame = 3

Query:  360 HRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSN-GVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLI--FSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQ----LNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNR--------LQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESD-ENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            HR+      T  LC  C + + G G   + C  C+  FH IC +   T   CQK   N    +  L Q  +  +++WS+  V++W+ ++N +   D+F  K+I G D++     D ++L N+          I D F+++ +   +  L                     LKQ   D+S   + +    E+  H + + SF+    C  CN+ + GL  QG  C  CG   H+ CA    L LC  ++   +   + SIFG  L LQ    +   PL +  C  EL+ R  NN++    ++ YS   A+     + EL    + +E  N V + + +   +A ++K +L+ELP+P+I    Y   +ES K    D+ C + +  ++  +P  +  TL YL+ HF  I +    +  ++    LI      L+ PP   + +       H RII+L     L+L   +   L   +       + +++     L      I+ ++   EWYWG+  +EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  R+G YGF EP  F SV +LI +Y+   LS+YN  L+I L YP SK   E +    E        L+  +H+ + D  ++  +V   TE +N+  +E+    + L  + ++       +FQ         +++   H    L      L ++L    +  ++++E  ++    +  L R+L   +P+++ L R        L  + ++L + R++ +     ++ D  D + +  E D EN   ND                       +  WF+ N  R+ +E+ L  +  GTFL+R S     +AL +  NG+  HC I       GF +    + SL+ LV  +   SL  HN SL T L YP+
Sbjct:  104 HRLGDVYFLTPILCGHCKDYVWGCGRVGVQCKDCHACFHKICVR-FATNYVCQK--NNEVLTAATLDQ--DKPITEWSSSTVVEWMAALNLYPYADVFRCKDIKGSDLVHL---DKEKLMNM---------GIKDEFHQKAILSCVSEL---------------------LKQP--DDSSVTVDQYNYTEVYAHNLTQHSFSTLERCKKCNKFLRGLLHQGFICQDCGLVAHRTCA-ATGLPLCLPSVEKPLGTQSKSIFGEGLCLQFNSPDMPAPLIVVKCTQELESRAKNNTS----LELYSLYCASPPADQVNEL--RQKLNESPNNVDLSEYSPACIANVLKKFLRELPDPIIPVQWYDRFLESSKLR-NDEQCSTLLGRLVQEIPEHHRSTLTYLMSHFCRICQMEYARGNRNPPTILIQTMCHILLRPPWERIIQVVYNTQAHNRIIEL-----LLLHCDWNETLPKFAGAPAVPPRKVSRIGASILDKEKSSISTNLQDAEWYWGDIKREEVNEKLNDTVDGTFLVRDASSKG-GEYTLTLR----------------KGGTNKLIKICHRNGKYGFTEPYTFSSVVELINHYRNDSLSQYNASLDIKLLYPISKNNQEEEIANTENIDKLTANLVE-VHNKLLDKNKLFEQV---TEDFNKTSQEVTSKRQALDALKEL-----VKVFQDQTKTQEKFQSEAQPHEIKTLMDNADLLKQRLKMMEESCEQLDENLQRQEAYNRSLERELTSLKPEIRDLMRECDNYQRWLITRGVKLARIRQLLN-----KDDDGTDGVDQTEECDIENLPHND-----------------------EKTWFVANCSRSMAEQYLAGKPDGTFLVRPS-STHQFALSIACNGITNHCIIQKTKRGLGFAEPYNIYDSLKSLVLHYSQNSLEIHNDSLNTTLRYPI 938

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:103046618])

HSP 1 Score: 176.407 bits (446), Expect = 2.885e-45
Identity = 156/596 (26.17%), Postives = 267/596 (44.80%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDS--LPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P+P+I   IY+ ++  V++    + C   +  +  S  +P     TL+  ++H   + ++     L ++  + IFS TL    +            H RI++++   +               +     +  MN N      +AL +        EWYWG+ S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L+YP SK +       +++ +  N E +   LH         N + D+  E Y    +E+          +E  KI +  +Q QT   +  ++I +     N  E    +       ++L  ++++ V   + + E  +K   E  E+ +K+   +PDL +L + + Q +     + V     +E   ++N +N +    ++E DE+   +D                       + +W + NI R ++E LL+ ++ GTFL+R S + G YA  V V+  V+HC I      +GF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  195 PQPVIHSAIYNDMVHIVQEVQGSEECAQHLRRVASSSAMPPQYWLTLQCFLRHLAHVCQASAVNLLNARALAEIFSPTLF---RQQASSCEPNPESHIRILEVLVTSEWSSSQAAPALPPKPPKPTPVTNNGMNNN------MALHDA-------EWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRHESLAQYNPKLDVKLQYPVSKHQQ------DQVVKEDNIEAVGTKLHEYHQQFQAKNKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKEYIEKFRREGNDKE----IQRIMVNYEKLKSRISEIVDSKRRLEEDLKKQAAEYREIDKKMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGIKN-ENQEDQYAMVEDDEDLPHHD-----------------------ERSWKLGNINRIQAEALLRGKRDGTFLVRDSSKPGCYACSVVVDSEVKHCVINKTPTGFGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPV 722

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:103046618])

HSP 1 Score: 167.548 bits (423), Expect = 1.306e-42
Identity = 154/596 (25.84%), Postives = 265/596 (44.46%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDS--LPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P+P+I   IY+ ++  V++    + C   +  +  S  +P     TL+  ++H   + ++     L ++  + IFS TL    +            H RI++++   +               +     +  MN N      +AL +        EWYWG+ S++EVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L+YP SK +       +++ +  N E +   LH         N + D+  E Y    +E+          +E  KI +  +Q QT   +  ++I +     N  E    +       ++L  ++++ V   + + E  +K   E  E+ +K+   +PDL +L + + Q +     + V     +E   ++N +N +    ++E DE+   +D                       + +W + NI R ++E LL+ ++ GTFL+R S + G YA  V     V+HC I      +GF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  151 PQPVIHSAIYNDMVHIVQEVQGSEECAQHLRRVASSSAMPPQYWLTLQCFLRHLAHVCQASAVNLLNARALAEIFSPTLF---RQQASSCEPNPESHIRILEVLVTSEWSSSQAAPALPPKPPKPTPVTNNGMNNN------MALHDA-------EWYWGDISRQEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRHESLAQYNPKLDVKLQYPVSKHQQ------DQVVKEDNIEAVGTKLHEYHQQFQAKNKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKEYIEKFRREGNDKE----IQRIMVNYEKLKSRISEIVDSKRRLEEDLKKQAAEYREIDKKMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGIKN-ENQEDQYAMVEDDEDLPHHD-----------------------ERSWKLGNINRIQAEALLRGKRDGTFLVRDSSKPGCYACSVV---EVKHCVINKTPTGFGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPV 675

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Match: ENSAMXT00000043367.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02002343.1:239988:244063:1 gene:ENSAMXG00000034321.1 transcript:ENSAMXT00000043367.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 150.214 bits (378), Expect = 3.585e-38
Identity = 126/440 (28.64%), Postives = 206/440 (46.82%), Query Frame = 3

Query: 1842 EEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELD----EITKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLND------CVQVAK------EMNERREKL-------ITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLV 3071
            E  ++ +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+              Y  + L++       +I  V  K+ +    Y E  KE D    E TK  + I   +T     N+ I       ++ ER     +S++ +++  ++ ND       +  AK      E+++ + +L         ++ E  +K+   +PDL +L +++ Q +     + V     ++   ++N +N D    + E DEN    D                       +++WF+ ++ RT+SE+LL  +  G FLIR S + G YA  V V+G V+HC I+     YGF +    + +L+DL 
Sbjct:   56 EAASSSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSDPLTFSSVVELISHYRHESLAQYNTKLDVKLMYPISR--------------YQQDQLVK-----EDNIDAVGKKLQEYHNQYQEKSKEYDRLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKEYIERFRREGNDKEIERIMMNYAKLKSRLGEIHDSKIRLEQDLKTQALDNRETDKKMNSLKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENTDEAYFVSEEDENLPHYD-----------------------ETSWFVGDLNRTQSEDLLLGKPDGAFLIRESSKKGCYACSVVVDGEVKHCVIYSTPRGYGFAEPYNLYSTLKDLT 431

HSP 2 Score: 60.077 bits (144), Expect = 9.302e-9
Identity = 32/97 (32.99%), Postives = 54/97 (55.67%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIR--RSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            W+  +I R E  + L++   GTFL+R   ++  G+Y L +   G  +  KI+ ++GKYGF  +  +F S+ +L+  +   SLA +N  L   L YP+
Sbjct:   67 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF-SDPLTFSSVVELISHYRHESLAQYNTKLDVKLMYPI 162

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Match: pik3r3b (phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [Source:ZFIN;Acc:ZDB-GENE-040426-743])

HSP 1 Score: 146.747 bits (369), Expect = 8.797e-36
Identity = 127/463 (27.43%), Postives = 205/463 (44.28%), Query Frame = 3

Query: 1842 EEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELD----EITKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLND------CVQVAK------EMNERREKL-------ITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            E  ++ +   EWYWG+ S+EEVND +  + DG FL                                   G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP S+              Y  + L++       +I  V  K+ +    Y E  KE D    E TK  + I   +T     N+ I       ++ ER     +S++ +++  ++ ND       +  AK      E+++ + +L         ++ E  +K+   +PDL +L +++ Q +     + V     ++   ++N +N D    + E DEN    D +                       +WF+ ++ RT+SE+LL  +  G FLIR S + G YA  V V+G V+HC I+     YGF +    + +L+DLV  +H  SL  HN SL   LAYPV
Sbjct:  309 EAASSSLQDAEWYWGDISREEVNDKLRDMPDGTFLSTGC-------------------------------GNNKLIKIYHRDGKYGFSDPLTFSSVVELISHYRHESLAQYNTKLDVKLMYPISR--------------YQQDQLVK-----EDNIDAVGKKLQEYHNQYQEKSKEYDRLYEEYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKEYIERFRREGNDKEIERIMMNYAKLKSRLGEIHDSKIRLEQDLKTQALDNRETDKKMNSLKPDLIQLRKIRDQYLVWLNHKGVRQKRINDWLGIKN-ENTDEAYFVSEEDENLPHYDET-----------------------SWFVGDLNRTQSEDLLLGKPDGAFLIRESSKKGCYACSVVVDGEVKHCVIYSTPRGYGFAEPYNLYSTLKDLVLHYHQTSLVQHNDSLNVRLAYPV 692

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Match: ENSAMXT00000040806.1 (phosphatidylinositol 3-kinase regulatory subunit gamma-like [Source:NCBI gene;Acc:103035767])

HSP 1 Score: 105.916 bits (263), Expect = 2.377e-24
Identity = 51/116 (43.97%), Postives = 68/116 (58.62%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYP 2207
            I   EWYWG+ S+EE ++ +  L DG FLVRD+S+K  G YTL++R                K+   +LVRI   DG +GF EP  F SVP+LI Y+Q H L++YN  L+I L  P
Sbjct:   36 IQDAEWYWGDISREEASEKLNSLPDGSFLVRDASNKVPGQYTLSLR----------------KDNSTRLVRITQHDGLFGFCEPLTFTSVPELISYHQQHSLAQYNPALDITLTRP 135

HSP 2 Score: 73.559 bits (179), Expect = 1.955e-13
Identity = 41/96 (42.71%), Postives = 53/96 (55.21%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIRRSRELGN-YALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            WF+ N+ R E+EELL  +  G FLIR S    + YA  V VN  V+HC I      +GF +      SL+ LV+ +H  SLA HN +L   LA PV
Sbjct:  203 WFVGNLSRAEAEELLDGKPSGAFLIRSSGTRKDCYACSVMVNDEVRHCMIIRTPRGFGFAEPYDLHGSLKALVQHYHHTSLAQHNRALDVRLAIPV 298

HSP 3 Score: 51.6026 bits (122), Expect = 2.556e-6
Identity = 29/97 (29.90%), Postives = 51/97 (52.58%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIRRS--RELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            W+  +I R E+ E L +   G+FL+R +  +  G Y L +  +   +  +I   +G +GF + + +F S+ +L+      SLA +NP+L   L  PV
Sbjct:   41 WYWGDISREEASEKLNSLPDGSFLVRDASNKVPGQYTLSLRKDNSTRLVRITQHDGLFGFCEPL-TFTSVPELISYHQQHSLAQYNPALDITLTRPV 136

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Match: pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-030131-1280])

HSP 1 Score: 172.94 bits (437), Expect = 1.640e-46
Identity = 127/442 (28.73%), Postives = 212/442 (47.96%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVN+ +    DG +LVRD+S K  G YTLT+R                K G NKL++I  RD  YGF EP  F SV +LI +Y+   L++YN +L++ L+YP SK         +++ +  N + + + L     D  + +   DK  E Y    +E+          +E  KI +     Q    K   +      + +  + +  + + LQ    +L++       + +  +K  TE+ E+ + +   +PDL +L +++ Q +     + V     +E   ++N DN +    I++ +EN    D                       + +W++ +I R ++E++L++R +GTFLIR+S + G YA  V V G V+HC IF ++  YGF +    + SL +LV  +   SL  HN SL   LA+PV
Sbjct:   64 LQDAEWYWGDISREEVNEKLRNTPDGTYLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIFHRDSKYGFSEPLTFNSVVELITHYRHESLAQYNPKLDVKLQYPVSK------SQQDQVVKEDNIDAVGKKLQELHKDYQDKSHDYDKLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQRHTQERYTKEYIERFKREGNEKEIERIMLNYEKLQS---RLSEIRDSKLRLEQDLKKQATENREIDKLMNSIKPDLIQLRKIRDQYLMWLTHKGVRQKKINEWLGIKN-DNTEDPYSIIDEEENLPHQD-----------------------EKSWYVPDINREKAEDMLRDRANGTFLIRKSSKHGFYACSVVVYGEVKHCMIFSRSTGYGFAEPYNLYGSLRELVLHYQQTSLVQHNDSLNVTLAHPV 456

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Match: chn2 (chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5])

HSP 1 Score: 73.1738 bits (178), Expect = 3.669e-14
Identity = 73/259 (28.19%), Postives = 121/259 (46.72%), Query Frame = 3

Query:  957 SFTGKIICDYCNRIMIGLQKQGVHC--IKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLV--GIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVK-KDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQK--LQSKKWSLIFSKTLIWP-PQIMVKEFTALKSRHQRII 1709
            +F G   C+YC   M GL  QGV C  + CG N HK C   +    C+ +   +  VF   +      L K H   +P+ ++ CI E++ R L  S G   +   S       T + KE        E++++     +D+N   +   +KLY +ELP PL+ Y  Y   +E+ K  D  +++   Q+   L +LP  + +TL  L+ H H    S  ++   + S+  S++F  TL+ P  Q ++     +  RHQR++
Sbjct:   54 TFRGPHWCEYCANFMWGLIAQGVKCSALDCGLNVHKQCCRLVPTD-CQPDPRRLPKVFGCDLTA----LVKAHRGRLPMVVEMCIGEIEARGL-KSEGLYRVSGVSDLVEEVRTAFDKE-------GEKADISAKAYEDVN--VITGALKLYFRELPTPLVTYQAYPHFVEAAKVSDPAERL--EQLRRALQTLPPAHYDTLHCLMAHLHRRRVSQQEKHNLMSSENLSIVFGPTLMRPHEQDVLATLNGM--RHQRLL 293

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Match: chn2 (chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5])

HSP 1 Score: 59.3066 bits (142), Expect = 6.106e-10
Identity = 61/227 (26.87%), Postives = 109/227 (48.02%), Query Frame = 3

Query: 1038 CGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVG--IKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVK-KDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRII 1709
            CG N HK C+ ++    CE ++ +V  V++  +      L K H+   P+ +  CI E++ R L +   + L     ++    D        A  R  E++++      DIN   +   +KLY ++LP PLI Y  Y   IE+ K  D ++++    I+  L  LP  + E+LRYL+ H   +     +  + ++  +++F  TL+ PP+  V   T    R+QR++
Sbjct:    3 CGLNVHKQCS-KVVPHDCEPDLKHVKKVYSCDLTT----LVKAHNRKRPMVVDMCIKEIEMRGLRS---EGLYRVSGFSEHIEDV-----KMAFDRDGEKADISANSYDDIN--IITGALKLYFRDLPIPLITYDAYPKFIEASKLMDADERL--EGIHEALRLLPPAHYESLRYLMAHLKRVTLYSKENLMSAENLAIVFGPTLMRPPEQDVLA-TLNDIRYQRLV 211

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002350.1 (pep scaffold:Pmarinus_7.0:GL490795:1252:4138:-1 gene:ENSPMAG00000002143.1 transcript:ENSPMAT00000002350.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 1.570e-9
Identity = 35/96 (36.46%), Postives = 54/96 (56.25%), Query Frame = 3

Query: 2859 FIENIERTESEELLKNRQHGTFLIR-RSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVK 3143
            F E +ER+ + ++L +  HGT+L+R R R+   YA+ +  N  V+H KI  + GK+  I     F+SL  LV+ + + SL     +L T L YP K
Sbjct:    1 FAEVLERSAAGDILMSCPHGTYLVRGRVRDQREYAISIRHNDEVKHIKIVAKEGKF-HITETKRFKSLVQLVEYYQVHSLKEGFSALDTNLKYPYK 95

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Match: si:ch1073-416j23.1 (si:ch1073-416j23.1 [Source:ZFIN;Acc:ZDB-GENE-100922-35])

HSP 1 Score: 56.225 bits (134), Expect = 3.677e-8
Identity = 62/247 (25.10%), Postives = 99/247 (40.08%), Query Frame = 3

Query:  948 RETSFTGKII-----CDYC-NRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKE-------LFAHPRFDEESNLVGI-KDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLI 1646
            R+ SF  K +     C  C NRI  G  K    C  C    H  C     L      +P+++        G   D     +  +P  +  C+DE++ R      G   +  Y    +  D   LKE       L A  R D    + G+ KD             L+ L EPL+ + ++H+ +++++   ED    + +Y  +  LP PN +TL YL+ H   + ES  + K+     S +F  TL+
Sbjct:  285 RQHSFVPKTVIKPESCVPCGNRIKFG--KLAHKCRDCRMVAHAECREHCPLPC----VPHILGTCRDYGEGTVADFSPPTAPMIPSLVLHCVDEIERR------GMMEVGLYRIPGSDRDVKELKERWLRGKGLPALARVDNVHVVCGLLKDF------------LRSLKEPLLTHRLHHTFLKAIEISDEDNRAAA-MYGAIGQLPQPNRDTLAYLMLHLQRVAES-TECKMNQSNLSRVFGPTLV 505

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Match: EDO48108 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK55])

HSP 1 Score: 98.2117 bits (243), Expect = 9.265e-23
Identity = 87/277 (31.41%), Postives = 130/277 (46.93%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKL--KPEVKGHVNELYQYTNEG-LIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQ----LNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRL 2669
            +   EWYWG  SKE VN  M   +DG F+VRDS  +  G YTLT+                 K G  KL+RI+ +DG YGF EP  F+SV  L+ YY+   L++YN +L++ L +P S+   + EV    N+ Y     G L+ +    M   TE     +K  + Y ++ +E+ ++  IL    + Q      I + + +    +R     H R  L+Q    L  +LND           + +L     EL  K Q +R   KR+N L+ +II L
Sbjct:    1 LKKAEWYWGEASKEAVNARMRDTEDGTFIVRDSK-RFPGEYTLTLM----------------KGGVIKLIRIMYKDGKYGFSEPLTFKSVIDLVSYYKDRSLAQYNPKLDVKLAHPLSRFEQEGEVPPEKNDEYMTKMVGDLVDINKEFMGSSTE----YEKLYKHYTDSSEEIADLQMIL----EAQRSVISMIEEQLRLHEHFQREASPEH-RGLLRQNYELLKHRLNDA----------KLELGNSERELSNKTQDNRLADKRMNSLRPKIIEL 241

HSP 2 Score: 64.3142 bits (155), Expect = 3.698e-11
Identity = 32/96 (33.33%), Postives = 54/96 (56.25%), Query Frame = 3

Query: 2856 WFIENIERTESEELLKNRQHGTFLIRRSREL-GNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            W+     +      +++ + GTF++R S+   G Y L +   GV++  +I  ++GKYGF     +F+S+ DLV  +  RSLA +NP L   LA+P+
Sbjct:    6 WYWGEASKEAVNARMRDTEDGTFIVRDSKRFPGEYTLTLMKGGVIKLIRIMYKDGKYGF-SEPLTFKSVIDLVSYYKDRSLAQYNPKLDVKLAHPL 100

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Match: EDO42176 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S254])

HSP 1 Score: 88.1965 bits (217), Expect = 4.170e-18
Identity = 84/287 (29.27%), Postives = 131/287 (45.64%), Query Frame = 3

Query:  939 HKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSI---FGVNL-DLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELF----AHPRFD----EESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDK-MCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKS----RHQRI-IQLIFEYKLVLID 1745
            H  +  +F G   CD+C   + GL  QGV C  CG N HK C          + IPN        I   FGV+L  L KLH+   P  +  CI+E++ R L++         Y  +   +D   LK  F     H   +    E  NL    DIN   +  + KLY ++LP PLI +  Y   I + K   +DK +   ++   L  LP  + ET+++L+ H H + +  +K  +  +  S++F  TL+  P     E  +L S    + QR+ ++L+  ++ VL D
Sbjct:  193 HNFKTNTFKGPHWCDHCRNFLWGLTMQGVKCQDCGFNAHKQCT---------KAIPNNCKPDKKYIKRAFGVDLTTLVKLHNTKRPFVVDICINEVEKRGLDSEG------LYRVSGFADDIEALKNSFDKGNTHTTVNYSDGESVNLSTYDDIN--TITGVCKLYFRQLPLPLITFETYSKFIAAAKT--QDKHLRIEELSKALGELPQAHYETMKFLMGHLHRVSQRRSKNMMTEENLSIVFGPTLMRAP-----EGDSLDSLVDMKFQRLAVELLISHQHVLFD 455

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Match: EDO47441 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM51])

HSP 1 Score: 57.3806 bits (137), Expect = 2.961e-8
Identity = 60/223 (26.91%), Postives = 102/223 (45.74%), Query Frame = 3

Query:  996 IMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCE--ENIPNVINVFNSSIFGVNLD-LQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIES-VKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWP 1652
            I I L KQG              A  ++LQ  +  + I    +V +  +FGV+++ +    S  +PL +  C+ E++ R L        +  Y  + A++D   LKE F     + +S LV + + +   +A L K+YL++LPEPL    +Y   +++    D E+K     +  +  SLP+PN  T  YL QH   + E     K+     S +F   ++ P
Sbjct:  575 ITIALDKQG--------------AITLSLQYSKTRQGIERKKSVNSVGVFGVDIETVTSRESCDIPLIVIGCVREIEKRGLEE------VGIYRLSGASSDVKRLKEGFDE---NSQSALVLVSEADIHAVAGLFKMYLRDLPEPLFTDELYDKFVKAYAMADAEEKR--ETMLELFQSLPTPNRLTACYLFQHLRKVAEKSEVHKMGLNNLSTVFGPNVLRP 772

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Match: EDO41241 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Z5])

HSP 1 Score: 53.9138 bits (128), Expect = 3.405e-7
Identity = 35/120 (29.17%), Postives = 53/120 (44.17%), Query Frame = 3

Query:  900 SKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMD 1259
            +K+ E   I   +H++   S+     CD+C +++ GL +QG+ C  CG NFHK CA++I    C ++   +   FN+           L  N  P    C    LQ     N  G  L D
Sbjct:   89 AKVPEDETIA-RSHQLAVHSYKSPTFCDFCGQMLYGLVRQGLKCDGCGGNFHKRCAYRIR-NNCSDSKHRISGHFNT-----------LPRNVAPGLDLCTPPSLQPINSWNEGGHNLRD 195

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Match: EDO49086 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI38])

HSP 1 Score: 48.1358 bits (113), Expect = 2.495e-6
Identity = 28/104 (26.92%), Postives = 54/104 (51.92%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFE-DKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIF 1721
            PE L+   +Y S IE+ +KD   ++M    +  +++ LP  N ETLR+L+ H   + E  +  K++++  +++F  TL+   +  +       S   RI++ I 
Sbjct:   54 PEGLVTAELYESFIEANRKDDPVERM--GALKMLINELPDHNYETLRHLLTHLKHVAEHADTNKMEARNLAIVFGPTLVRTGEDTMMSMVKDMSDQCRIVETIL 155

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:101171597])

HSP 1 Score: 172.555 bits (436), Expect = 5.032e-46
Identity = 136/455 (29.89%), Postives = 215/455 (47.25%), Query Frame = 3

Query: 1848 INNDINSQ------EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            INN +N+       EWYWG  S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + R L        E N + D+  E Y    +E+          +E  KI +  +Q QT   +   +I +     N  E    +       ++L  ++++ V   + + E   K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N +    ++E DE+   +D                       +  W +E I+R E+E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   28 INNGMNNNMALQDAEWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKQQQ------DQVVKEDNIEAVGRKLCEYHQQYQEKNKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKDYIERFRKEGNEKE----IQRIMGNYEKLKSRISEIVDSKRRLEEDLRKQAADYREIDKRMNSIKPDLIQLRKTRDQYLTWLTQKGVRQKKLNEWLGIKN-ENTEDQYSMVEDDEDLPHHD-----------------------ERTWKLEKIDRLEAEGLLQGKRDGTFLVRESSKPGCYACSVMVDGEVKHCVINKTPSGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 430

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:101171597])

HSP 1 Score: 172.94 bits (437), Expect = 6.027e-46
Identity = 136/455 (29.89%), Postives = 215/455 (47.25%), Query Frame = 3

Query: 1848 INNDINSQ------EWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            INN +N+       EWYWG  S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + R L        E N + D+  E Y    +E+          +E  KI +  +Q QT   +   +I +     N  E    +       ++L  ++++ V   + + E   K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N +    ++E DE+   +D                       +  W +E I+R E+E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:   51 INNGMNNNMALQDAEWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKQQQ------DQVVKEDNIEAVGRKLCEYHQQYQEKNKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKDYIERFRKEGNEKE----IQRIMGNYEKLKSRISEIVDSKRRLEEDLRKQAADYREIDKRMNSIKPDLIQLRKTRDQYLTWLTQKGVRQKKLNEWLGIKN-ENTEDQYSMVEDDEDLPHHD-----------------------ERTWKLEKIDRLEAEGLLQGKRDGTFLVRESSKPGCYACSVMVDGEVKHCVINKTPSGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 453

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:101171597])

HSP 1 Score: 176.407 bits (446), Expect = 2.691e-45
Identity = 159/596 (26.68%), Postives = 267/596 (44.80%), Query Frame = 3

Query: 1413 PEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILD--SLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTN-EGLIRLLHSTMSDITEVNAKVDKNTETYNENQKEL----------DEITKILKGIDQIQT---WCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVP----DEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            P+P++   +   ++ + K+    + C   +  +    SLP      L  L++HF  + +S +K  L  +    IFS       Q  V    +L + + +II+++   +               +    ++  MN N      +AL++        EWYWG  S+EEVN+ +    DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF +P  F SV +LI +Y+   L++YN +L++ L YP SK +       +++ +  N E + R L        E N + D+  E Y    +E+          +E  KI +  +Q QT   +   +I +     N  E    +       ++L  ++++ V   + + E   K   +  E+ +++   +PDL +L + + Q +     + V     +E   ++N +N +    ++E DE+   +D                       +  W +E I+R E+E LL+ ++ GTFL+R S + G YA  V V+G V+HC I      YGF +    + SL++LV  +   SL  HN SL   LAYPV
Sbjct:  195 PQPVVHPALQVQMVHTAKEVANPEECAQLLRRVASTPSLPHQYWLALHCLLRHFARVCQSGSKNLLSPRTLGEIFSPVFFR--QQSVGCEPSLDA-YIKIIEVLVTTEWSESRAAPALPPKPPKPAAVINNGMNNN------MALQDA-------EWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLR----------------KGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKQQ------QDQVVKEDNIEAVGRKLCEYHQQYQEKNKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE--EQCQTQERYSKDYIERFRKEGNEKE----IQRIMGNYEKLKSRISEIVDSKRRLEEDLRKQAADYREIDKRMNSIKPDLIQLRKTRDQYLTWLTQKGVRQKKLNEWLGIKN-ENTEDQYSMVEDDEDLPHHD-----------------------ERTWKLEKIDRLEAEGLLQGKRDGTFLVRESSKPGCYACSVMVDGEVKHCVINKTPSGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 722

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Match: pik3r3b (phosphoinositide-3-kinase regulatory subunit 3 [Source:NCBI gene;Acc:101170665])

HSP 1 Score: 167.162 bits (422), Expect = 5.964e-44
Identity = 139/446 (31.17%), Postives = 212/446 (47.53%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEI----TKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHR---KLQMD--------RPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNI-DAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF EP  F SV  LI +Y+   L++YN +L++ L YP S+ + +         Q   E           +I  V  K+ +    Y +  K+ D +    TK  + I   +T     N+ I       ++ ER     +S+D +++ +++ ND       MN   EKL +   E+H    +L+ D        R   K++N L+  +I+L   R++ D+     N   +           +NE+ ++ S    +  N+           ++ +WF+ N+ R E+EELL  +  G FLIR S + G YA  V V+G V+HC I+     +GF +    + SL+DLV  +   SL  HN SL   LAYPV
Sbjct:   57 LQEAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSEPLTFNSVVDLISHYRHESLAQYNTKLDVKLMYPVSRFQQD---------QLVKE----------DNIDAVGKKLQEYHNQYQDKSKDYDRLYEDYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKDYIERFHREGNDKEIERIMMN--YEKLKSRLGEIHDSKVRLEQDLKTQAMDNRETDKKMNSLKPDLIQL---RKIRDQYLVWLNHKGVRQKRINDWLGLKNENTDESSFVSEEEENLPH--------YDEKSWFVGNLNRMEAEELLIGKSDGVFLIRESSKKGCYACSVVVDGEVKHCVIYSTPRGFGFAEPYNLYSSLKDLVLHYQQTSLVQHNDSLNVRLAYPV 449

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Match: pik3r3b (phosphoinositide-3-kinase regulatory subunit 3 [Source:NCBI gene;Acc:101170665])

HSP 1 Score: 167.162 bits (422), Expect = 7.611e-44
Identity = 139/446 (31.17%), Postives = 212/446 (47.53%), Query Frame = 3

Query: 1860 INSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEI----TKILKGIDQIQTWC---NKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHR---KLQMD--------RPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNI-DAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPV 3140
            +   EWYWG+ S+EEVND +  + DG FLVRD+S K  G YTLT+R                K G NKL++I  RDG YGF EP  F SV  LI +Y+   L++YN +L++ L YP S+ + +         Q   E           +I  V  K+ +    Y +  K+ D +    TK  + I   +T     N+ I       ++ ER     +S+D +++ +++ ND       MN   EKL +   E+H    +L+ D        R   K++N L+  +I+L   R++ D+     N   +           +NE+ ++ S    +  N+           ++ +WF+ N+ R E+EELL  +  G FLIR S + G YA  V V+G V+HC I+     +GF +    + SL+DLV  +   SL  HN SL   LAYPV
Sbjct:   68 LQEAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR----------------KGGNNKLIKIYHRDGKYGFSEPLTFNSVVDLISHYRHESLAQYNTKLDVKLMYPVSRFQQD---------QLVKE----------DNIDAVGKKLQEYHNQYQDKSKDYDRLYEDYTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQER-----YSKDYIERFHREGNDKEIERIMMN--YEKLKSRLGEIHDSKVRLEQDLKTQAMDNRETDKKMNSLKPDLIQL---RKIRDQYLVWLNHKGVRQKRINDWLGLKNENTDESSFVSEEEENLPH--------YDEKSWFVGNLNRMEAEELLIGKSDGVFLIRESSKKGCYACSVVVDGEVKHCVIYSTPRGFGFAEPYNLYSSLKDLVLHYQQTSLVQHNDSLNVRLAYPV 460

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BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST
Match: SMESG000078199.1 (SMESG000078199.1)

HSP 1 Score: 2017.28 bits (5225), Expect = 0.000e+0
Identity = 1009/1025 (98.44%), Postives = 1009/1025 (98.44%), Query Frame = 3

Query:   75 MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD 3149
            MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDIYLAKLIKLYLKELPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTI                RKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPNLNNPINNKSNWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD
Sbjct:    1 MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDIYLAKLIKLYLKELPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTI----------------RKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPNLNNPINNKSNWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD 1009

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST
Match: SMESG000078199.1 (SMESG000078199.1)

HSP 1 Score: 1965.27 bits (5090), Expect = 0.000e+0
Identity = 988/1025 (96.39%), Postives = 988/1025 (96.39%), Query Frame = 3

Query:   75 MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFHGNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKNDYSLYQIKSTNMRQAPXXXXXXXXXXXWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD 3149
            MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDIYLAKLIKLYLKELPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTI                RKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEI                     MRQAPNLNNPINNKSNWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD
Sbjct:    1 MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVTQNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFKKSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKFLKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNINGKDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDIYLAKLIKLYLKELPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFEYKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQEWYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTI----------------RKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEYNDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNAKVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERTDWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRPDLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEI---------------------MRQAPNLNNPINNKSNWFIENIERTESEELLKNRQHGTFLIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVKTFHMRSLASHNPSLTTVLAYPVKCD 988

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST
Match: SMESG000057671.1 (SMESG000057671.1)

HSP 1 Score: 71.633 bits (174), Expect = 1.917e-12
Identity = 87/348 (25.00%), Postives = 152/348 (43.68%), Query Frame = 3

Query:  687 SQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKITGTLECKTRDILDLNDLKQTA-------HDNSG-SKIK--EKYIIELAN--------HKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNL-DLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAAT----NDTIYLKELFAHPRFDEESNLVGIKDINDXXXXXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCS--QIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLIWPP 1655
            SQ P  S  L++   NN+T   Q+    + + ++   + L+D  ++ ++   T    +  DL Q++        + SG S+I      +IE  N        H  ++ +F G   CD+C   M GL  QGV C  CG   HK C+ ++      +  P +  +    +FG+ L  L K+ +  +PL  +  I  L+ R LN+    ++              N  I   +    PRF +   L G+  +           +L++LP PLI   +Y +LI S++K  EDK+     Q  + +  L S +  TL + ++H + + +      + S   ++IF+ TLI  P
Sbjct:  258 SQRP--SLILESPSSNNSTLSSQMTTGSHYEQIFDCRNNLLDDSMSISVFDSTELPNNTKDLSQSSPGSDRKSSNRSGLSRILSLRTPVIEQQNSFKQLEKSHNFKQHTFVGPQWCDFCAHFMWGLVAQGVQCFDCGFQAHKKCSDKV----AADCFPVMKRM--KRVFGIELTSLAKMENRAIPLVFEKLIQALEDRDLNSQGLYRISGNIDLIEEVRIDLNKDIESVDFKGDPRFRDIETLTGLIKL-----------FLRQLPIPLITSELYTNLI-SIRK-AEDKIPIRYYQFRNTMSILNSVHYATLEFFIRHLNKVSQFHRTNFMTSSNLAIIFAPTLICKP 584

[Close]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST
Match: SMESG000066507.1 (SMESG000066507.1)

HSP 1 Score: 63.929 bits (154), Expect = 4.689e-10
Identity = 63/250 (25.20%), Postives = 113/250 (45.20%), Query Frame = 3

Query:  918 YIIELANHKMRETSFTGKIICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVFNSSIFGVNL-DLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYTAATNDTIYLKELFAHPRFDEESNLVGIKDINDXXX------XXXXXXXXXXXPEPLIAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHLIWESCNKQKLQSKKWSLIFSKTLI 1646
            Y  +   H  +  +F G   CD+C   M GL  QGV C  CG   H+ C+ ++      + +P++  +    +FG+ L  L K+   GVP+ I   ++E++ R      G ++   Y  +  +       EL    + D + ++  I    D  L      + LIKL+ ++LP PL+   +   L++ +K     K+   Q    L  LP  +  TL+YL+ H + +       K+  +  ++IF+ +LI
Sbjct:  356 YAEQEKQHNFKTHTFKGPHWCDFCTHFMWGLVAQGVKCQDCGFQAHRKCSDRV----PSDCLPDMKRL--KRVFGIELTSLGKVEKRGVPMIIMRLVEEVEAR------GMEIEGIYRVSGNS-------ELIDEVKADLDKDIDSIDMEKDGRLCEIHNISSLIKLFFRQLPIPLVTLEVSSMLMDIIKTQENQKVRLEQFTDCLLRLPLVHYATLKYLMAHLYKLSSFSEINKMTVENLAIIFAPSLI 586

The following BLAST results are available for this feature:

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Zebrafish
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Yeast
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PIK3R1	3.781e-49	27.10	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
PIK3R1	3.781e-49	27.10	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
PIK3R1	5.238e-47	29.27	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
PIK3R1	1.321e-46	29.11	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
PIK3R3	6.290e-44	28.80	phosphoinositide-3-kinase regulatory subunit 3 [So...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
aap-1	5.127e-10	28.46	Phosphoinositide 3-kinase adapter subunit; Phospho...	[more]
aap-1	5.127e-10	28.46	Phosphoinositide 3-kinase adapter subunit; Phospho...	[more]
chin-1	1.428e-8	25.00	CHImaeriN (Rac-GTPase-activating protein) homolog ...	[more]
spv-1	4.656e-7	27.20	Spermathecal Physiology Variant [Source:UniProtKB...	[more]
spv-1	5.060e-7	27.20	Spermathecal Physiology Variant [Source:UniProtKB...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pi3K21B	1.537e-26	26.61	gene:FBgn0020622 transcript:FBtr0331208	[more]
Pi3K21B	1.537e-26	26.61	gene:FBgn0020622 transcript:FBtr0331205	[more]
Pi3K21B	6.763e-16	38.95	gene:FBgn0020622 transcript:FBtr0331206	[more]
Pi3K21B	6.763e-16	38.95	gene:FBgn0020622 transcript:FBtr0331207	[more]
RhoGAP5A	3.451e-8	23.67	gene:FBgn0029778 transcript:FBtr0070785	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pik3r1	7.175e-49	27.33	phosphoinositide-3-kinase, regulatory subunit 1 (a...	[more]
pik3r1	7.175e-49	27.33	phosphoinositide-3-kinase, regulatory subunit 1 (a...	[more]
pik3r1	6.140e-47	29.89	phosphoinositide-3-kinase, regulatory subunit 1 (a...	[more]
pik3r3b	9.477e-46	30.75	phosphoinositide-3-kinase, regulatory subunit 3b (...	[more]
pik3r3b	9.477e-46	30.75	phosphoinositide-3-kinase, regulatory subunit 3b (...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PIK3R1	1.394e-44	26.49	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
hvcn1	1.534e-44	28.28	hydrogen voltage gated channel 1 [Source:Xenbase;A...	[more]
hvcn1	2.031e-44	28.28	hydrogen voltage gated channel 1 [Source:Xenbase;A...	[more]
hvcn1	2.057e-44	28.28	hydrogen voltage gated channel 1 [Source:Xenbase;A...	[more]
hvcn1	2.227e-44	28.28	hydrogen voltage gated channel 1 [Source:Xenbase;A...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pik3r1	3.770e-50	27.44	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
Pik3r1	2.467e-46	29.09	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
Pik3r3	5.763e-45	29.73	phosphoinositide-3-kinase regulatory subunit 3 [So...	[more]
Gm49337	1.876e-44	29.64	predicted gene, 49337 [Source:MGI Symbol;Acc:MGI:6...	[more]
Pik3r2	5.204e-42	28.64	phosphoinositide-3-kinase regulatory subunit 2 [So...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P26450\|P85A_MOUSE	2.637e-49	27.44	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
sp\|Q5R685\|P85A_PONAB	1.380e-48	27.10	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
sp\|P27986\|P85A_HUMAN	1.816e-48	27.10	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
sp\|Q63787\|P85A_RAT	6.302e-47	26.60	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
sp\|P23727\|P85A_BOVIN	7.094e-47	27.10	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C3YA44	3.110e-69	26.91	Uncharacterized protein OS=Branchiostoma floridae ...	[more]
A0A2P6K857	8.089e-68	27.23	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
A0A4Y2HHT6	6.166e-67	26.47	Phosphatidylinositol 3-kinase regulatory subunit a...	[more]
A0A0M3TCH6	2.966e-65	27.00	PI3K21B OS=Leptinotarsa decemlineata OX=7539 PE=2 ...	[more]
A0A1Y1KD31	1.412e-64	26.30	Uncharacterized protein OS=Photinus pyralis OX=705...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pik3r1	2.885e-45	26.17	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
pik3r1	1.306e-42	25.84	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
ENSAMXT00000043367.1	3.585e-38	28.64	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
pik3r3b	8.797e-36	27.43	phosphoinositide-3-kinase, regulatory subunit 3b (...	[more]
ENSAMXT00000040806.1	2.377e-24	43.97	phosphatidylinositol 3-kinase regulatory subunit g...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pik3r1	1.640e-46	28.73	phosphoinositide-3-kinase, regulatory subunit 1 (a...	[more]
chn2	3.669e-14	28.19	chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5]	[more]
chn2	6.106e-10	26.87	chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5]	[more]
ENSPMAT00000002350.1	1.570e-9	36.46	pep scaffold:Pmarinus_7.0:GL490795:1252:4138:-1 ge...	[more]
si:ch1073-416j23.1	3.677e-8	25.10	si:ch1073-416j23.1 [Source:ZFIN;Acc:ZDB-GENE-10092...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO48108	9.265e-23	31.41	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42176	4.170e-18	29.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47441	2.961e-8	26.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41241	3.405e-7	29.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49086	2.495e-6	26.92	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pik3r1	5.032e-46	29.89	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
pik3r1	6.027e-46	29.89	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
pik3r1	2.691e-45	26.68	phosphoinositide-3-kinase regulatory subunit 1 [So...	[more]
pik3r3b	5.964e-44	31.17	phosphoinositide-3-kinase regulatory subunit 3 [So...	[more]
pik3r3b	7.611e-44	31.17	phosphoinositide-3-kinase regulatory subunit 3 [So...	[more]

BLAST of Phosphatidylinositol 3-kinase regulatory subunit alpha vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000078199.1	0.000e+0	98.44	SMESG000078199.1	[more]
SMESG000078199.1	0.000e+0	96.39	SMESG000078199.1	[more]
SMESG000057671.1	1.917e-12	25.00	SMESG000057671.1	[more]
SMESG000066507.1	4.689e-10	25.20	SMESG000066507.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30006764 ID=SMED30006764|Name=Phosphatidylinositol 3-kinase regulatory subunit alpha|organism=Schmidtea mediterranea sexual|type=transcript|length=3287bp
TTTCAAAATAGGAATTAACTTTTTTTGTGATAATTTATTGTTTTTTTCTA
TTACTATCTGGCAAAATAAATGAAATGTTTATTGTATTGAAATGTGTTAT
CGACTTCGATCGACCATATTGTGATAATTTTCAATATTTAAATTCCATAA
AAGATGATATTATAATTTGTGATTCTCTTTGCCATATTAAAAGTGATGTT
TTTGGATTCGGCAAGAATGTTACACAAAACACATATGGATTATTTTCATT
CAATAATTTTGTTATGATTGATAGGACAATGTATGTAAGTGAAGAACTTC
TTTTAGCAGTTGTGGAATATACAGATCCAGTTATAAAAAAAGACGTTCCA
GTCAGATATCATCGAGTGTTTAAAAAAAGTGTTGGTACAATTTCTCTATG
CTTTATCTGCGGAGAAAACATGATGGGATTGGGATTAGACTTCATTTACT
GCACTAGTTGTAATCAAGTATTTCACAGTATTTGCCATAAAAACCACAAA
ACTTTCAAAAGTTGCCAGAAATTTCTAAAAAATACAAATAAAGATTCTGT
AGAACTATTTCAATCGACTGAAATGTCTTTATCCGATTGGTCCAATGAAC
AAGTTTTACAGTGGCTTTGTTCTGTGAATTTCTTTCGATTGGTTGATTTA
TTTGAAAACAAAAATATAAACGGAAAGGATATTTTATCTCAGATGCCTCA
AGATTCCAAAGAGCTTGACAATTTAGAGCATAATAATGCTACGTTTTGGG
GTCAGATTGCTGATCCTTTTTATCGGCAGACACTCTACTATGCATTGCAT
GCATTAATCGATACGAAAATTACAGGAACACTTGAATGTAAAACGAGGGA
TATTCTTGATCTCAATGACTTGAAACAGACTGCACATGACAATTCTGGTT
CGAAAATAAAAGAAAAATACATTATAGAATTGGCTAATCACAAAATGAGA
GAAACCTCATTCACAGGAAAAATAATTTGTGATTATTGTAATCGAATAAT
GATAGGGTTACAAAAACAAGGAGTTCACTGCATTAAATGCGGCAACAATT
TTCATAAAGTTTGTGCATTTCAAATTAATTTACAATTGTGTGAGGAAAAT
ATCCCAAACGTGATAAATGTGTTCAACAGTTCAATATTTGGTGTCAACCT
TGATCTACAGAAATTACATTCTAATGGAGTGCCATTGTTTATCAAATGTT
GTATTGATGAATTACAACATAGATGTCTTAATAATAGTAATGGACAGAAA
TTAATGGATGCATACAGTTATACTGCTGCTACAAATGACACTATTTACCT
GAAGGAATTATTTGCCCACCCAAGATTTGATGAAGAATCCAATTTAGTCG
GGATCAAAGATATTAATGATATATATTTGGCGAAATTGATTAAATTGTAT
TTAAAAGAGCTTCCAGAGCCATTGATTGCCTATGGTATCTACCATAGTTT
AATAGAAAGTGTTAAGAAAGATTTTGAAGATAAGATGTGCTGTTCACAAA
TTTATTCAATACTCGACAGTCTTCCGTCGCCGAACATCGAGACTCTTCGT
TATCTAGTTCAACATTTTCATTTGATTTGGGAAAGTTGCAATAAGCAAAA
GTTACAATCCAAAAAATGGTCTCTTATATTTTCTAAAACTCTCATTTGGC
CTCCACAAATTATGGTCAAGGAATTTACTGCCCTTAAATCCAGACATCAG
AGAATTATACAGCTTATATTTGAATACAAATTGGTGTTGATTGATAAATT
TACTTGGCCACTGGTATCAGTTTCTGAAGAACAAATGTCTCTGTCGCAAT
CGATGAATAAAAACCAGTTGGGTTGTTTACAGATAGCTTTGGAAGAAATT
AATAACGACATCAATTCCCAAGAATGGTATTGGGGTAATACTTCAAAAGA
AGAGGTCAATGACTACATGACGGGCTTGCAAGATGGATATTTTTTGGTTA
GAGACTCATCAGATAAAGCTTTGGGAATTTATACTTTGACAATTAGGGTT
TTAGTAAATACTGTCGAATTTCATGGCAATCAATTTAGTCAGCGAAAAGA
AGGAGAAAATAAATTAGTACGAATAATTTGTCGAGATGGGTTCTATGGAT
TCCAAGAACCGTGTAAATTTGAGTCTGTACCGAAATTGATAAAATATTAT
CAAACCCATAAACTTTCTGAATACAATGACCAACTAAATATCATGCTACG
ATATCCATGTTCGAAATTAAAACCTGAAGTTAAAGGTCATGTCAATGAAT
TGTATCAGTATACAAACGAAGGATTGATAAGATTACTTCATTCTACGATG
AGTGATATTACAGAAGTCAATGCCAAAGTTGATAAAAATACTGAAACGTA
CAATGAAAATCAAAAAGAATTAGATGAAATAACAAAAATTCTGAAAGGCA
TTGATCAAATCCAAACGTGGTGCAATAAGCATATTTTTCAAATAATGAAC
ATTATAAATTCAAATGAAAGAACTGATTGGGTGTCCCATTCAAGAGATTG
TCTTCAACAACTTAATAAAAAATTAAATGACTGTGTACAAGTGGCCAAGG
AAATGAACGAACGACGTGAGAAGCTGATCACCGAATCCGATGAGTTACAT
CGAAAATTACAAATGGATAGGCCGGATTTAAAAAGATTAAACCGACTGCA
GGCTCAAATTATCAGATTATTCAAAGACAGGGAAGTTCCAGATGAAATGT
TCAGTTTAGAAAATGTTGATAACATTGACGCAATGTGTGAAATACTGGAA
TCGGATGAGAATGAAGATAAAAATGATTATAGTCTTTATCAAATAAAGTC
AACAAACATGAGGCAAGCTCCAAATTTAAATAACCCTATAAATAATAAAT
CCAATTGGTTTATTGAGAACATCGAAAGAACCGAATCAGAAGAACTGTTA
AAAAACCGACAACATGGTACCTTTCTAATTAGACGAAGCCGTGAACTAGG
AAATTACGCTTTGGATGTGAATGTCAATGGAGTTGTTCAGCATTGCAAAA
TCTTTTGTCAAAATGGAAAATATGGATTTATCAAAAACGTTTGTTCTTTT
CAAAGTCTGGAAGATCTTGTCAAAACGTTTCATATGCGTAGTTTAGCCTC
ACACAATCCTTCTTTAACTACAGTTTTAGCATACCCTGTTAAATGTGATT
GAAATTGTTTGACAATTTAGTAGATTATGAGAACTATTAGGCAGTTGTAT
ATATTTATTTTTCTATGCGCTGCTGTATTTATTCTAAATCAAACAGAGAG
CGTTTGCTAATTTAATCGTGCTGTATTCTGCTTTGGA

protein sequence of SMED30006764-orf-1

>SMED30006764-orf-1 ID=SMED30006764-orf-1|Name=SMED30006764-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1026bp
MFIVLKCVIDFDRPYCDNFQYLNSIKDDIIICDSLCHIKSDVFGFGKNVT
QNTYGLFSFNNFVMIDRTMYVSEELLLAVVEYTDPVIKKDVPVRYHRVFK
KSVGTISLCFICGENMMGLGLDFIYCTSCNQVFHSICHKNHKTFKSCQKF
LKNTNKDSVELFQSTEMSLSDWSNEQVLQWLCSVNFFRLVDLFENKNING
KDILSQMPQDSKELDNLEHNNATFWGQIADPFYRQTLYYALHALIDTKIT
GTLECKTRDILDLNDLKQTAHDNSGSKIKEKYIIELANHKMRETSFTGKI
ICDYCNRIMIGLQKQGVHCIKCGNNFHKVCAFQINLQLCEENIPNVINVF
NSSIFGVNLDLQKLHSNGVPLFIKCCIDELQHRCLNNSNGQKLMDAYSYT
AATNDTIYLKELFAHPRFDEESNLVGIKDINDIYLAKLIKLYLKELPEPL
IAYGIYHSLIESVKKDFEDKMCCSQIYSILDSLPSPNIETLRYLVQHFHL
IWESCNKQKLQSKKWSLIFSKTLIWPPQIMVKEFTALKSRHQRIIQLIFE
YKLVLIDKFTWPLVSVSEEQMSLSQSMNKNQLGCLQIALEEINNDINSQE
WYWGNTSKEEVNDYMTGLQDGYFLVRDSSDKALGIYTLTIRVLVNTVEFH
GNQFSQRKEGENKLVRIICRDGFYGFQEPCKFESVPKLIKYYQTHKLSEY
NDQLNIMLRYPCSKLKPEVKGHVNELYQYTNEGLIRLLHSTMSDITEVNA
KVDKNTETYNENQKELDEITKILKGIDQIQTWCNKHIFQIMNIINSNERT
DWVSHSRDCLQQLNKKLNDCVQVAKEMNERREKLITESDELHRKLQMDRP
DLKRLNRLQAQIIRLFKDREVPDEMFSLENVDNIDAMCEILESDENEDKN
DYSLYQIKSTNMRQAPNLNNPINNKSNWFIENIERTESEELLKNRQHGTF
LIRRSRELGNYALDVNVNGVVQHCKIFCQNGKYGFIKNVCSFQSLEDLVK
TFHMRSLASHNPSLTTVLAYPVKCD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036860	SH2_dom_sf
IPR000980	SH2
IPR000198	RhoGAP_dom
IPR013761	SAM/pointed_sf
IPR002219	PE/DAG-bd
IPR008936	Rho_GTPase_activation_prot

Vocabulary: **biological process**
Term	Definition
GO:0035556	intracellular signal transduction
GO:0007165	signal transduction
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0016310	phosphorylation

Vocabulary: **molecular function**
Term	Definition
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0016301	kinase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005942	phosphatidylinositol 3-kinase complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 810..844
None	No IPR available	GENE3D	G3DSA:3.30.60.20		coord: 272..346 e-value: 1.8E-12 score: 48.7
None	No IPR available	PANTHER	PTHR10155:SF10	PI3K21B, ISOFORM B	coord: 370..1023
None	No IPR available	PANTHER	PTHR10155	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT	coord: 370..1023
None	No IPR available	CDD	cd00159	RhoGAP	coord: 370..551 e-value: 2.14677E-18 score: 81.5792
None	No IPR available	SUPERFAMILY	SSF57889	Cysteine-rich domain	coord: 83..143
None	No IPR available	SUPERFAMILY	SSF57889	Cysteine-rich domain	coord: 275..335
IPR000980	SH2 domain	PRINTS	PR00401	SH2DOMAIN	coord: 991..1005 score: 29.63 coord: 947..957 score: 51.74 coord: 928..942 score: 39.75 coord: 958..969 score: 31.12
IPR000980	SH2 domain	SMART	SM00252	SH2_5	coord: 926..1008 e-value: 2.2E-17 score: 73.7 coord: 599..698 e-value: 2.6E-18 score: 76.8
IPR000980	SH2 domain	PFAM	PF00017	SH2	coord: 928..1001 e-value: 3.5E-16 score: 59.0 coord: 601..692 e-value: 8.0E-9 score: 35.5
IPR000980	SH2 domain	PROSITE	PS50001	SH2	coord: 928..1022 score: 16.989
IPR000980	SH2 domain	PROSITE	PS50001	SH2	coord: 601..712 score: 15.669
IPR000198	Rho GTPase-activating protein domain	SMART	SM00324	RhoGAP_3	coord: 367..553 e-value: 7.5E-12 score: 55.4
IPR000198	Rho GTPase-activating protein domain	PFAM	PF00620	RhoGAP	coord: 370..528 e-value: 6.8E-19 score: 68.2
IPR000198	Rho GTPase-activating protein domain	PROSITE	PS50238	RHOGAP	coord: 359..556 score: 23.223
IPR013761	Sterile alpha motif/pointed domain superfamily	GENE3D	G3DSA:1.10.150.50		coord: 168..223 e-value: 2.5E-6 score: 29.7
IPR013761	Sterile alpha motif/pointed domain superfamily	SUPERFAMILY	SSF47769	SAM/Pointed domain	coord: 169..205
IPR036860	SH2 domain superfamily	GENE3D	G3DSA:3.30.505.10		coord: 920..1024 e-value: 3.1E-25 score: 90.1
IPR036860	SH2 domain superfamily	GENE3D	G3DSA:3.30.505.10		coord: 582..721 e-value: 1.1E-26 score: 95.0
IPR036860	SH2 domain superfamily	SUPERFAMILY	SSF55550	SH2 domain	coord: 925..1022
IPR036860	SH2 domain superfamily	SUPERFAMILY	SSF55550	SH2 domain	coord: 595..714
IPR008936	Rho GTPase activation protein	GENE3D	G3DSA:1.10.555.10		coord: 348..557 e-value: 7.0E-27 score: 95.9
IPR008936	Rho GTPase activation protein	SUPERFAMILY	SSF48350	GTPase activation domain, GAP	coord: 353..551
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PROSITE	PS00479	ZF_DAG_PE_1	coord: 289..339
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PROSITE	PS00479	ZF_DAG_PE_1	coord: 96..147
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PROSITE	PS50081	ZF_DAG_PE_2	coord: 95..147 score: 8.776
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	PROSITE	PS50081	ZF_DAG_PE_2	coord: 288..339 score: 11.201

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Phosphatidylinositol 3-kinase regulatory subunit alpha

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

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