Homeobox domain-containing protein

Overview
NameHomeobox domain-containing protein
Smed IDSMED30006682
Length (bp)1303
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Homeobox domain-containing protein (SMED30006682) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox domain-containing protein (SMED30006682) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30006682

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30006682SMESG000029688.1 SmedASXL_019746SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
X2 cellSMED30006682SMESG000029688.1 SmedASXL_019746SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
head regionSMED30006682SMESG000029688.1 dd_Smed_v6_37930_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX4 (SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890])

HSP 1 Score: 239.195 bits (609), Expect = 4.475e-73
Identity = 112/177 (63.28%), Postives = 133/177 (75.14%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ +   C+CE L +   +  L  FL  L  +      +ES++KARA+V F +G Y ELYSILE++ F++ NH  LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKEKSR ALK+ YK+ RYP+P EKR LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   98 LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDL-LRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNP 273          
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX2 (SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888])

HSP 1 Score: 228.409 bits (581), Expect = 2.334e-71
Identity = 106/178 (59.55%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX1 (SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887])

HSP 1 Score: 227.254 bits (578), Expect = 4.348e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX4 (SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890])

HSP 1 Score: 240.35 bits (612), Expect = 5.120e-71
Identity = 112/177 (63.28%), Postives = 133/177 (75.14%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ +   C+CE L +   +  L  FL  L  +      +ES++KARA+V F +G Y ELYSILE++ F++ NH  LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKEKSR ALK+ YK+ RYP+P EKR LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:  106 LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDL-LRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNP 281          
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SIX5 (SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891])

HSP 1 Score: 216.468 bits (550), Expect = 2.508e-67
Identity = 103/174 (59.20%), Postives = 124/174 (71.26%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F+ EQ  C+CE L++      L  FL  L          + V++ARA+V F++G Y ELY +LE+  F   +H+ LQ L+ +A Y EA+  RGR LGAVDKYRLR+KFPLPKTIWDGEETVYCFKE+SR ALK  Y+  RYPTP+EKR LA  TGLSLTQVSNWFKNRRQRDRT
Sbjct:   14 FSPEQVACVCEALLQAGHAGRLSRFLGALPPA-ERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRT 186          
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-33 (Homeobox protein ceh-33 [Source:UniProtKB/Swiss-Prot;Acc:Q94166])

HSP 1 Score: 190.274 bits (482), Expect = 1.731e-57
Identity = 91/175 (52.00%), Postives = 123/175 (70.29%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIK-REKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            ++ EQ  CICE L     K+S  V  + + D    E   ++ ++KA+A + F   N++ELY I+E++ F + +H  LQ  W  AHY EA+ +RGR LGAV KYR+RRK+PLP+TIWDGEET YCF++KSR  L+D Y +  YP+P EKR+LA+KT L++TQVSNWFKNRRQRDR 
Sbjct:   20 YSEEQVACICEALSNDARKLSQFVWTVLERD----EMRNNQYILKAQAFLAFHSNNFKELYRIIESHHFASEHHLPLQEWWLNAHYHEAEKIRGRQLGAVGKYRIRRKYPLPRTIWDGEETSYCFRDKSRVLLRDWYCRNSYPSPREKRELAEKTHLTVTQVSNWFKNRRQRDRA 190          
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-34 (Homeobox protein ceh-34 [Source:UniProtKB/Swiss-Prot;Acc:Q94165])

HSP 1 Score: 185.652 bits (470), Expect = 7.935e-56
Identity = 93/194 (47.94%), Postives = 128/194 (65.98%), Query Frame = 1
Query:  256 MNQQTNAMNYEERKFAFTLEQTVCICEVL----IKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            M Q  N  N      +++ ++ VCICE L    ++  +   L NF+ +L      ++  ESV+KA+A+V F   N++ LY +LE ++F  +NH+ LQ LW  AHY EA   + R LGAV KYR+R+K P P TIWDGEET YCFK KSR  L+D+YKK +YP+ E+KR LA++T LS+ QVSNWFKN+RQR+R 
Sbjct:    1 MQQSYNPQNSLTATTSYSEQEIVCICESLFNEGLQTGRTEQLANFIYNLPQC---YQVMESVLKAQALVYFTTQNWKMLYKLLECSKFSPHNHTVLQNLWLDAHYKEAAKTKDRELGAVCKYRIRKKNPFPNTIWDGEETNYCFKSKSRNVLRDAYKKCQYPSVEDKRRLAQQTELSIIQVSNWFKNKRQRERA 191          
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-32 (Homeobox protein ceh-32 [Source:UniProtKB/Swiss-Prot;Acc:Q23175])

HSP 1 Score: 166.392 bits (420), Expect = 1.841e-46
Identity = 78/169 (46.15%), Postives = 111/169 (65.68%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHT-EFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
             T +Q V  CE L     +  L  F+  +    T E   +E+ ++ARA+V F   ++RELY+ILENN+F    H  LQ +W++AHY E +  RG+ L AVDKYR+R+K+P+P+TIWDGE+  +CFKE++R  L++ Y K  YP P +K++LA  TGL+  QV NWFKNR
Sbjct:   68 LTADQIVKTCEQLETDGDVDGLFRFMCTIPPQKTQEVAGNEAFLRARALVCFHASHFRELYAILENNKFSPKYHPKLQEMWHEAHYREQEKNRGKSLCAVDKYRVRKKYPMPRTIWDGEQKTHCFKERTRSLLREWYLKDPYPNPPKKKELANATGLTQMQVGNWFKNR 236          
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: unc-39 (Homeobox protein unc-39 [Source:UniProtKB/Swiss-Prot;Acc:O17894])

HSP 1 Score: 153.295 bits (386), Expect = 1.293e-42
Identity = 74/179 (41.34%), Postives = 110/179 (61.45%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDT----NHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKK-KRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            +++EQ   I   L +      LV F   L++    N  +  + E+++ A    L+    +  L+ +L N  F   +++ LQ +W+ A Y E+Q  RG+ L  V+KYRLRRKFP PKTIWDGEE VY FK+ SR+ LK  ++    YPT E+KR++++ TGL + Q+SNWFKNRRQRD++
Sbjct:   97 YSMEQMEAISTSLFQARDGDRLVAFFKQLESLYGPNAVDHLRSEAIIVAYTYALYHSNEFETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKRGKELNPVEKYRLRRKFPAPKTIWDGEEIVYSFKDSSRKFLKQFFRNVSEYPTQEQKREISRATGLKIVQISNWFKNRRQRDKS 275          
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Six4 (gene:FBgn0027364 transcript:FBtr0078274)

HSP 1 Score: 235.343 bits (599), Expect = 3.694e-73
Identity = 111/182 (60.99%), Postives = 137/182 (75.27%), Query Frame = 1
Query:  286 EERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            + +   F+ +Q  C+CE L ++  I  L  FL  L  +   F+ +ESV++ARA+V +  G + ELY++LE + F    H  LQ LW++AHY EA+ VRGRPLGAVDKYRLR+K+PLPKTIWDGEETVYCFKEKSR ALKD Y   RYPTP+EK+ LAKKTGL+LTQVSNWFKNRRQRDRTPQ
Sbjct:  175 DAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEF-FKTNESVLRARAMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQ 355          
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Six4 (gene:FBgn0027364 transcript:FBtr0078275)

HSP 1 Score: 235.343 bits (599), Expect = 3.694e-73
Identity = 111/182 (60.99%), Postives = 137/182 (75.27%), Query Frame = 1
Query:  286 EERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            + +   F+ +Q  C+CE L ++  I  L  FL  L  +   F+ +ESV++ARA+V +  G + ELY++LE + F    H  LQ LW++AHY EA+ VRGRPLGAVDKYRLR+K+PLPKTIWDGEETVYCFKEKSR ALKD Y   RYPTP+EK+ LAKKTGL+LTQVSNWFKNRRQRDRTPQ
Sbjct:  175 DAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEF-FKTNESVLRARAMVAYNLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQ 355          
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: so (gene:FBgn0003460 transcript:FBtr0088970)

HSP 1 Score: 229.95 bits (585), Expect = 7.518e-71
Identity = 107/183 (58.47%), Postives = 133/183 (72.68%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFAS 846
            F FT EQ  C+CEVL +   I  L  FL  L     + + +ESV+KA+A+V F +G Y+ELY +LE++ F   NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L+D Y    YP+P EKRDLA+ TGL+ TQVSNWFKNRRQRDR  +++  S
Sbjct:  101 FGFTQEQVACVCEVLQQAGNIERLGRFLWSLPQC-DKLQLNESVLKAKAVVAFHRGQYKELYRLLEHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDGS 282          
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Optix (gene:FBgn0025360 transcript:FBtr0088865)

HSP 1 Score: 181.03 bits (458), Expect = 1.942e-51
Identity = 85/173 (49.13%), Postives = 116/173 (67.05%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDT---NHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
             AF+  Q   +C+ L     I  L  FL  L     N  E    E+V++ARA+V +  GN+RELY+I+EN++F   ++  LQ +W +AHY EA+ +RGR LG VDKYR+R+KFPLP TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LAK TGL+ TQV NWFKNR
Sbjct:   35 LAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNR 207          
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Optix (gene:FBgn0025360 transcript:FBtr0329885)

HSP 1 Score: 181.03 bits (458), Expect = 2.075e-51
Identity = 85/173 (49.13%), Postives = 116/173 (67.05%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDT---NHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
             AF+  Q   +C+ L     I  L  FL  L     N  E    E+V++ARA+V +  GN+RELY+I+EN++F   ++  LQ +W +AHY EA+ +RGR LG VDKYR+R+KFPLP TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LAK TGL+ TQV NWFKNR
Sbjct:   35 LAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNR 207          
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six4a (SIX homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-010201-2])

HSP 1 Score: 236.113 bits (601), Expect = 4.568e-75
Identity = 111/177 (62.71%), Postives = 134/177 (75.71%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ EQ  C+CE L +   +  L  FL  L  +      +ES+++A+A+V F +  Y+ELYSILE++ F  + HS LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKE+SR ALKD YK+ RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   80 LAFSPEQVACVCEALQQGGNVDRLARFLWSLPQSDL-LRGNESILRAQALVAFHQARYQELYSILESHSFSPSCHSALQDLWYKARYTEAEKARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKERSRNALKDLYKQNRYPSPAEKRNLAKITGLSLTQVSNWFKNRRQRDRNP 255          
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six4b (SIX homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-010201-1])

HSP 1 Score: 245.743 bits (626), Expect = 1.409e-74
Identity = 112/177 (63.28%), Postives = 135/177 (76.27%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ EQ  C+CE L++   +  L  FL  L  +      +ES++KA+AIV F    Y+ELY ILEN+ F  +NHS+LQ +WY+A Y EA+  RGRPLGAVDKYRLRRK+PLP+TIWDGEETVYCFKE+SR ALKD YK+ RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   63 LAFSPEQVACVCEALMQGGNVDRLARFLWSLPQSDL-LRGNESILKAQAIVAFHHARYQELYCILENHSFSPSNHSSLQDMWYKARYTEAEKARGRPLGAVDKYRLRRKYPLPRTIWDGEETVYCFKERSRNALKDMYKRNRYPSPAEKRNLAKMTGLSLTQVSNWFKNRRQRDRNP 238          
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six4a (SIX homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-010201-2])

HSP 1 Score: 238.81 bits (608), Expect = 3.787e-72
Identity = 111/177 (62.71%), Postives = 134/177 (75.71%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ EQ  C+CE L +   +  L  FL  L  +      +ES+++A+A+V F +  Y+ELYSILE++ F  + HS LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKE+SR ALKD YK+ RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   80 LAFSPEQVACVCEALQQGGNVDRLARFLWSLPQSDL-LRGNESILRAQALVAFHQARYQELYSILESHSFSPSCHSALQDLWYKARYTEAEKARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKERSRNALKDLYKQNRYPSPAEKRNLAKITGLSLTQVSNWFKNRRQRDRNP 255          
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six1a (SIX homeobox 1a [Source:NCBI gene;Acc:494168])

HSP 1 Score: 227.639 bits (579), Expect = 1.861e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+ +F T+NH  +Q LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESYQFSTHNHPKMQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: six2b (SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-23])

HSP 1 Score: 227.639 bits (579), Expect = 2.023e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY +LE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  LK+ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGSIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKVLESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRCVLKEWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six2 (SIX homeobox 2 [Source:NCBI gene;Acc:100101784])

HSP 1 Score: 227.639 bits (579), Expect = 2.874e-71
Identity = 106/176 (60.23%), Postives = 129/176 (73.30%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE ++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACE-HLHKNESVLKAKAVVAFHRGNFRELYKILEGHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six1 (SIX homeobox 1 [Source:NCBI gene;Acc:100101702])

HSP 1 Score: 226.868 bits (577), Expect = 5.680e-71
Identity = 106/178 (59.55%), Postives = 131/178 (73.60%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: SIX4 (SIX homeobox 4 [Source:NCBI gene;Acc:100498150])

HSP 1 Score: 238.039 bits (606), Expect = 5.322e-70
Identity = 118/219 (53.88%), Postives = 144/219 (65.75%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEK-HESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP------------------QNQFASFYSPYDFHNSQDRVQNF 897
             AF+ E   C+CE L +   +  L  FL  L   H+E  + +ES++KARA+V F +G Y EL+ +LE++ F  +NH+ LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKEKSR ALK+ YK  RYP+P  KR+LAK TGLSLTQVSNWFKNRRQRDR P                   ++     SP+   NS D V N 
Sbjct:  148 LAFSPEHVACVCEALQQGGDLDRLSRFLCSLP--HSELLRGNESILKARALVTFHQGRYSELFLLLESHNFHPSNHAALQELWYKARYIEAEKARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKHNRYPSPAAKRNLAKVTGLSLTQVSNWFKNRRQRDRNPSEAQSKSESDGNHSTEDESSKGQDDLSPHPLSNSSDGVSNI 364          
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: tmem136 (transmembrane protein 136 [Source:Xenbase;Acc:XB-GENE-966251])

HSP 1 Score: 194.126 bits (492), Expect = 4.044e-58
Identity = 89/171 (52.05%), Postives = 119/171 (69.59%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFE---KHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
            F+ EQ   +CE L +   I  L  FL  L       E   KHES+++ARA+V F  GN+R+LY ILEN++F   +H  LQ +W +AHY EA+ +RGRPLG VDKYR+R+KFPLP+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA+ TGL+ TQV NWFKNR
Sbjct:   49 FSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNR 219          
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: six6 (SIX homeobox 6 [Source:NCBI gene;Acc:100101705])

HSP 1 Score: 191.43 bits (485), Expect = 8.498e-58
Identity = 91/171 (53.22%), Postives = 121/171 (70.76%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFE---KHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
            F+ +Q   +CE L +   I  L  FL  L       E   K+ESV++ARAIV F  GN+RELY ILEN++F  ++H+ LQ LW +AHY EA+ +RGRPLG VDKYR+R+KFPLP+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA+ TGL+ TQV NWFKNR
Sbjct:    9 FSPQQVAGVCETLEESGDIERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHTGNFRELYHILENHKFTKDSHTKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNR 179          
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six4 (sine oculis-related homeobox 4 [Source:MGI Symbol;Acc:MGI:106034])

HSP 1 Score: 238.81 bits (608), Expect = 6.686e-73
Identity = 112/177 (63.28%), Postives = 133/177 (75.14%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ +   C+CE L +   +  L  FL  L  +      +ES++KARA+V F +G Y ELYSILE++ F++ NH  LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKEKSR ALK+ YK+ RYP+P EKR LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   91 LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDL-LRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNP 266          
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six2 (sine oculis-related homeobox 2 [Source:MGI Symbol;Acc:MGI:102778])

HSP 1 Score: 228.794 bits (582), Expect = 1.115e-71
Identity = 106/178 (59.55%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six2 (sine oculis-related homeobox 2 [Source:MGI Symbol;Acc:MGI:102778])

HSP 1 Score: 228.794 bits (582), Expect = 1.115e-71
Identity = 106/178 (59.55%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six1 (sine oculis-related homeobox 1 [Source:MGI Symbol;Acc:MGI:102780])

HSP 1 Score: 227.639 bits (579), Expect = 2.434e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Six4 (sine oculis-related homeobox 4 [Source:MGI Symbol;Acc:MGI:106034])

HSP 1 Score: 240.35 bits (612), Expect = 3.016e-71
Identity = 112/177 (63.28%), Postives = 133/177 (75.14%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ +   C+CE L +   +  L  FL  L  +      +ES++KARA+V F +G Y ELYSILE++ F++ NH  LQ LWY+A Y EA+  RGRPLGAVDKYRLRRKFPLP+TIWDGEETVYCFKEKSR ALK+ YK+ RYP+P EKR LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   99 LAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDL-LRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNP 274          
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q62232|SIX2_MOUSE (Homeobox protein SIX2 OS=Mus musculus OX=10090 GN=Six2 PE=1 SV=2)

HSP 1 Score: 228.794 bits (582), Expect = 7.801e-71
Identity = 106/178 (59.55%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9NPC8|SIX2_HUMAN (Homeobox protein SIX2 OS=Homo sapiens OX=9606 GN=SIX2 PE=1 SV=1)

HSP 1 Score: 228.409 bits (581), Expect = 1.121e-70
Identity = 106/178 (59.55%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH+ LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPAC-EHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6DHF9|SIX1A_DANRE (Homeobox protein six1a OS=Danio rerio OX=7955 GN=six1a PE=2 SV=2)

HSP 1 Score: 227.639 bits (579), Expect = 1.405e-70
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+ +F T+NH  +Q LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESYQFSTHNHPKMQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q62231|SIX1_MOUSE (Homeobox protein SIX1 OS=Mus musculus OX=10090 GN=Six1 PE=1 SV=2)

HSP 1 Score: 227.639 bits (579), Expect = 1.702e-70
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NZ04|SIX1B_DANRE (Homeobox protein six1b OS=Danio rerio OX=7955 GN=six1b PE=1 SV=1)

HSP 1 Score: 227.254 bits (578), Expect = 1.816e-70
Identity = 106/178 (59.55%), Postives = 131/178 (73.60%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A0L8GJ62 (Homeobox domain-containing protein (Fragment) OS=Octopus bimaculoides OX=37653 GN=OCBIM_22032757mg PE=4 SV=1)

HSP 1 Score: 259.61 bits (662), Expect = 3.807e-81
Identity = 124/196 (63.27%), Postives = 149/196 (76.02%), Query Frame = 1
Query:  250 TSMNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQ 837
            TS +Q T       +  +F+ EQ  C+CE L ++  I  L  FL  L  N      +E+V+KARA V F +G++RELY+ILE++ FDT+NH+ LQ +WY+AHY EAQ +RGRPLGAVDKYRLRRK+PLPKTIWDGEETVYCFKEKSRQ LKD YK+ RYPTP+EKR LAKKTGL+LTQVSNWFKNRRQRDRTP   
Sbjct:   42 TSTDQLTITTAPGSKGLSFSPEQVACVCEALQQKGDIERLARFLWSLPPNEL-LRGNEAVLKARATVAFHRGSFRELYAILESHNFDTSNHNFLQQMWYKAHYMEAQKIRGRPLGAVDKYRLRRKYPLPKTIWDGEETVYCFKEKSRQVLKDCYKQNRYPTPDEKRSLAKKTGLTLTQVSNWFKNRRQRDRTPHTH 236          
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A2C9K5V2 (Homeobox domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106052480 PE=4 SV=1)

HSP 1 Score: 259.61 bits (662), Expect = 1.710e-80
Identity = 119/180 (66.11%), Postives = 144/180 (80.00%), Query Frame = 1
Query:  292 RKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            +K AF+ EQ  C+CE L ++  I  L  FL  L  +       E+V+KARA+V F +G+YRELY+ILE++ F+ +NH+ LQ LWY+AHY EAQ +RGRPLGAVDKYRLRRK+PLPKTIWDGEET+YCFKEKSRQALKD YK+ +YPTP+EKR LAK TGL+LTQVSNWFKNRRQRDRTP 
Sbjct:  100 KKLAFSPEQVACVCEALQQKNDIDRLARFLWSLPPSEL-LRGSEAVLKARAMVAFHRGSYRELYAILESHTFENSNHAFLQQLWYKAHYMEAQKIRGRPLGAVDKYRLRRKYPLPKTIWDGEETIYCFKEKSRQALKDCYKQNKYPTPDEKRSLAKNTGLTLTQVSNWFKNRRQRDRTPH 278          
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: V4AHM7 (Homeobox domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_115798 PE=4 SV=1)

HSP 1 Score: 256.144 bits (653), Expect = 5.554e-80
Identity = 120/182 (65.93%), Postives = 144/182 (79.12%), Query Frame = 1
Query:  292 RKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQ 837
            +   F+ EQ  C+CE L ++  I  L  FL  L  +       E+V+KARA V F +GNYRELY+ILE++ F+ +NH+ LQ LWY++HY EAQ +RGRPLGAVDKYRLRRK+PLPKTIWDGEET+YCFKEKSRQALK+ YK+ RYPTP+EKR LAKKTGL+LTQVSNWFKNRRQRDRTPQ Q
Sbjct:   38 KNLTFSPEQVSCVCEALQQKGDIERLARFLWSLPPSEL-LRGSEAVLKARATVSFHRGNYRELYAILESHTFEGSNHNFLQQLWYKSHYMEAQKIRGRPLGAVDKYRLRRKYPLPKTIWDGEETIYCFKEKSRQALKECYKQNRYPTPDEKRTLAKKTGLTLTQVSNWFKNRRQRDRTPQTQ 218          
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A1S3HBA6 (homeobox protein six1 OS=Lingula unguis OX=7574 GN=LOC106153769 PE=4 SV=1)

HSP 1 Score: 260.381 bits (664), Expect = 6.320e-80
Identity = 122/178 (68.54%), Postives = 142/178 (79.78%), Query Frame = 1
Query:  292 RKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            +   F+ EQ  C+CE L +   I  L  FL  L  +       E+V+KARAIV F +GN+RELY+ILE++ FDT NHS LQ LWY+AHY EAQ +RGRPLGAVDKYRLRRK+PLPKTIWDGEETVYCFKEKSRQALK+ YK+ RYPTP+EKR+LAKKTGL+LTQVSNWFKNRRQRDRT
Sbjct:   56 KNMTFSPEQVACVCEALQQSGNIDRLARFLWSLPPSEL-LRGSEAVLKARAIVAFHRGNFRELYAILESHNFDTVNHSMLQQLWYKAHYMEAQKIRGRPLGAVDKYRLRRKYPLPKTIWDGEETVYCFKEKSRQALKECYKQNRYPTPDEKRNLAKKTGLTLTQVSNWFKNRRQRDRT 232          
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A210R007 (Homeobox protein SIX4 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT10444 PE=4 SV=1)

HSP 1 Score: 259.996 bits (663), Expect = 1.797e-79
Identity = 122/185 (65.95%), Postives = 144/185 (77.84%), Query Frame = 1
Query:  292 RKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFAS 846
            +   F+ EQ  C+CE L ++  I  L  FL  L  +       E+V+KARA V F +G+YRELY+ILE++ F   NHS LQ LWY+AHY EAQ +RGRPLGAVDKYRLRRK+PLPKTIWDGEETVYCFKEKSRQALK+ YK+ RYPTP+EKR+LAKKTGL+LTQVSNWFKNRRQRDRTPQ Q  +
Sbjct:   82 KNLTFSPEQVACVCEALQQKGDIDRLARFLWSLPPSEL-LRGSEAVLKARATVAFHRGSYRELYAILESHEFHDTNHSFLQQLWYKAHYMEAQKIRGRPLGAVDKYRLRRKYPLPKTIWDGEETVYCFKEKSRQALKECYKQNRYPTPDEKRNLAKKTGLTLTQVSNWFKNRRQRDRTPQQQAVT 265          
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six4b (homeobox protein SIX4 [Source:NCBI gene;Acc:103035162])

HSP 1 Score: 246.899 bits (629), Expect = 2.770e-75
Identity = 115/195 (58.97%), Postives = 141/195 (72.31%), Query Frame = 1
Query:  244 LTTSMNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
            L  S  +  +A +      AF+ EQ  C+CE L++   +  L  FL  L  +      +ES++KA+AIV F +  Y+ELY ILE++ F   NHS+LQ +WY+A Y EA+  RGRPLGAVDKYRLRRK+PLP+TIWDGEETVYCFKEKSR ALKD YK+ RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   29 LPPSAEESLSAASCVSSPLAFSPEQVACVCEALLQGGDVERLARFLWSLPQSEL-LRGNESILKAQAIVAFHQARYQELYCILESHSFSPANHSSLQDMWYKARYSEAEKARGRPLGAVDKYRLRRKYPLPRTIWDGEETVYCFKEKSRNALKDMYKRNRYPSPAEKRNLAKITGLSLTQVSNWFKNRRQRDRNP 222          
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six4b (homeobox protein SIX4 [Source:NCBI gene;Acc:103035162])

HSP 1 Score: 246.514 bits (628), Expect = 5.656e-75
Identity = 115/195 (58.97%), Postives = 141/195 (72.31%), Query Frame = 1
Query:  244 LTTSMNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
            L  S  +  +A +      AF+ EQ  C+CE L++   +  L  FL  L  +      +ES++KA+AIV F +  Y+ELY ILE++ F   NHS+LQ +WY+A Y EA+  RGRPLGAVDKYRLRRK+PLP+TIWDGEETVYCFKEKSR ALKD YK+ RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   44 LPPSAEESLSAASCVSSPLAFSPEQVACVCEALLQGGDVERLARFLWSLPQSEL-LRGNESILKAQAIVAFHQARYQELYCILESHSFSPANHSSLQDMWYKARYSEAEKARGRPLGAVDKYRLRRKYPLPRTIWDGEETVYCFKEKSRNALKDMYKRNRYPSPAEKRNLAKITGLSLTQVSNWFKNRRQRDRNP 237          
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000021946.2 (homeobox protein six1b [Source:NCBI gene;Acc:103045548])

HSP 1 Score: 232.646 bits (592), Expect = 1.368e-73
Identity = 109/178 (61.24%), Postives = 131/178 (73.60%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE ++F T+NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L+D Y    YP+P EKR+LA+ TGLS TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACE-HLHKNESVLKAKAMVAFHRGNFRELYKILEGHQFSTHNHGKLQQLWLRAHYAEAERLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYTHNPYPSPREKRELAQATGLSTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six2b (SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-23])

HSP 1 Score: 228.409 bits (581), Expect = 1.179e-71
Identity = 114/210 (54.29%), Postives = 144/210 (68.57%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFAS--FYSPYDFHNSQDRVQNFKSERKYFP 921
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY +LE+++F  +NH  LQ LW +AHY EA+ VRGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  LK+ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQR   P+N+ A    ++P     S+ + Q   S+ +  P
Sbjct:    7 FGFTQEQVACVCEVLQQGGSIERLGRFLWSLPACE-HLHKNESVLKAKAVVAFHRGNFRELYKVLESHQFSPHNHPKLQQLWLKAHYMEAEKVRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRCVLKEWYSHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRG--PENEGAGQNGHNPLMSQMSESKSQGESSDDEKSP 213          
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: six1b (homeobox protein six1b [Source:NCBI gene;Acc:103034839])

HSP 1 Score: 227.639 bits (579), Expect = 1.891e-71
Identity = 106/178 (59.55%), Postives = 131/178 (73.60%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAE 183          
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: six1a (SIX homeobox 1a [Source:NCBI gene;Acc:494168])

HSP 1 Score: 191.045 bits (484), Expect = 6.553e-60
Identity = 88/148 (59.46%), Postives = 111/148 (75.00%), Query Frame = 1
Query:  367 LVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRR 810
            L  FL  L     + ++ ES++ A+A+V F +GN+RELY++LE+  F   NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKE+SR  L+D Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRR
Sbjct:    4 LGRFLWSLPACE-QIQRSESILMAKAVVAFHQGNFRELYAVLESQPFSARNHPKLQQLWLKAHYTEAERLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKERSRGVLRDWYAHNPYPSPREKRELAQATGLTTTQVSNWFKNRR 150          
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002854.1 (pep scaffold:Pmarinus_7.0:GL480305:17375:18769:1 gene:ENSPMAG00000002608.1 transcript:ENSPMAT00000002854.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 184.111 bits (466), Expect = 3.319e-56
Identity = 85/173 (49.13%), Postives = 120/173 (69.36%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFE---KHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
             +F+ +Q   +CE L +   I  L  FL  L      +E   + E+V++ARA+V F   NYR+LY+ILE ++F   +H+ LQ +W +AHY EA+ +RGRPLG VDKYR+R+KFPLP+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA+ TGL+ TQV NWFKNR
Sbjct:   39 LSFSPQQVASVCETLEESGDIERLGRFLWSLPVAPGAWEALNRQEAVLRARAVVAFHASNYRDLYAILEGHKFSKASHAKLQAMWLEAHYLEAERLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELAQATGLTPTQVGNWFKNR 211          
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: Six4 (pep scaffold:Pmarinus_7.0:GL478660:19078:19268:1 gene:ENSPMAG00000010180.1 transcript:ENSPMAT00000011207.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Six4)

HSP 1 Score: 109.768 bits (273), Expect = 4.331e-30
Identity = 50/63 (79.37%), Postives = 55/63 (87.30%), Query Frame = 1
Query:  622 KFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRR 810
            KFPLP+TIWDGEETVYCFKEKSR  LKD Y++ RYP P+EKR LAK TGLS+ QVSNWFKNRR
Sbjct:    1 KFPLPRTIWDGEETVYCFKEKSRNFLKDCYRRTRYPAPDEKRRLAKLTGLSVVQVSNWFKNRR 63          
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011157.1 (pep scaffold:Pmarinus_7.0:GL488016:7246:7434:-1 gene:ENSPMAG00000010130.1 transcript:ENSPMAT00000011157.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.9669 bits (219), Expect = 1.629e-22
Identity = 39/63 (61.90%), Postives = 50/63 (79.37%), Query Frame = 1
Query:  622 KFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRR 810
            KFPLPKTIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA+ TGL+ TQV NWFKNRR
Sbjct:    1 KFPLPKTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRR 63          
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001924.1 (pep scaffold:Pmarinus_7.0:GL488033:11:347:-1 gene:ENSPMAG00000001748.1 transcript:ENSPMAT00000001924.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 4.464e-10
Identity = 30/88 (34.09%), Postives = 44/88 (50.00%), Query Frame = 1
Query:  316 QTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVR 579
            Q  C+CE L +   ++ L  FL  L        + E+V++ARA V F  G+YRELY +LE + F+  +H+ L  L         Q  R
Sbjct:    1 QVACVCEALQQGGDVARLARFLWAL-PGPAAASRDEAVLRARAHVAFHSGSYRELYDVLEGHAFEARHHAALLALSLTCALSHLQVTR 87          
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO31034 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ27])

HSP 1 Score: 228.409 bits (581), Expect = 9.670e-74
Identity = 108/175 (61.71%), Postives = 133/175 (76.00%), Query Frame = 1
Query:  313 EQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQ 837
            +Q  C+C+ L +   I  L  FL  L  +       ESV+KARAIV F +G YRE+Y+ILE N FD ++H  LQ LWY+AHY EA+ +RGR LGAVDKYR+RRKFPLP+TIWDGEETVYCFKEK+R ALKD Y++ +YPTP+EKR +AK+T L+L QVSNWFKNRRQRDR P N+
Sbjct:    1 DQVACVCDALRQAGDIERLSRFLWSLPPDDL-LNGSESVLKARAIVSFHRGRYREVYNILETNEFDPSSHELLQCLWYKAHYSEAEKLRGRSLGAVDKYRIRRKFPLPRTIWDGEETVYCFKEKARAALKDCYEQNKYPTPQEKRLIAKQTNLTLKQVSNWFKNRRQRDRIPSNK 174          
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO34334 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPN4])

HSP 1 Score: 224.172 bits (570), Expect = 5.279e-72
Identity = 109/178 (61.24%), Postives = 132/178 (74.16%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F+FT EQ  C+CEVL +   I  L  FL  L    T  +K+ESV+KA+AIV F + N++ELY ILENN F  N H  LQ+LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +
Sbjct:    5 FSFTPEQVACVCEVLQQSGDIERLGRFLWSLPECET-IQKNESVLKAKAIVSFHQQNFQELYRILENNNFSPNAHPKLQSLWLKAHYMEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRNILREWYSHNPYPSPREKRELAEGTGLTTTQVSNWFKNRRQRDRAAE 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO42933 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S005])

HSP 1 Score: 206.068 bits (523), Expect = 5.813e-65
Identity = 97/176 (55.11%), Postives = 122/176 (69.32%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQ 831
            F++EQ + +CE L     I  L  FL  L  +  E    E+++ A+A+V F + N++ELYSILE+ +F  + H  LQ LW  AHY EA+ VRGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L  +Y    YPTP EK +LAK T L++TQVSNWFKN+RQR R  +
Sbjct:    3 FSMEQIISVCECLQNSGNIERLARFLWSLPKDSEEIHACETILVAKAVVAFHQNNFKELYSILESRKFQRSEHEKLQCLWRTAHYIEAERVRGRPLGAVGKYRVRRKFPLPRTIWDGEETTYCFKEKSRSILNKAYVDSPYPTPREKHELAKMTDLTVTQVSNWFKNKRQRVRAAE 178          
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO33059 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST96])

HSP 1 Score: 191.045 bits (484), Expect = 5.685e-59
Identity = 89/173 (51.45%), Postives = 119/173 (68.79%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFE---KHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNR 807
             +F+  Q   +CE L +   +  L  FL  L       E   KHESV++ARAIV F  GN+R+LY ILE +RF   +H+ LQ +W +AHY EA+ +RGRPLG VDKYR+R+KFPLP+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA+ TGL+ TQV NWFKNR
Sbjct:    8 LSFSAHQIAQVCETLEESGDVERLARFLWSLPVAPGTLEALGKHESVLRARAIVAFHMGNFRDLYHILETHRFTRESHAKLQAMWLEAHYQEAERLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAQATGLTPTQVGNWFKNR 180          
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO33407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SS98])

HSP 1 Score: 184.496 bits (467), Expect = 7.935e-57
Identity = 88/166 (53.01%), Postives = 119/166 (71.69%), Query Frame = 1
Query:  313 EQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRR 810
            +Q  CIC+ L +   I  L  FL  +     +  K ES++KARA+V F +G Y+E+Y+ILENN+FDT++H  LQ LWY+AHY E + +RGR L AVDK+R+R+K PLP TI DGE+T+Y FKEK R  LK+ Y+ K+YPT +EKR +A +T L+L QV NWF+NRR
Sbjct:    1 DQVACICDALFQEGDIKRLSQFLLSIPQEDLQ-NKSESLLKARAMVAFHRGCYQEVYNILENNKFDTSSHEFLQCLWYKAHYSEGEKLRGRSLSAVDKFRIRKKSPLPNTISDGEKTIYFFKEKVRTVLKECYEHKKYPTLKEKRVIATQTNLTLRQVRNWFRNRR 165          
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six4a (SIX homeobox 4 [Source:NCBI gene;Acc:101159478])

HSP 1 Score: 240.35 bits (612), Expect = 4.149e-72
Identity = 110/177 (62.15%), Postives = 134/177 (75.71%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
             AF+ EQ  C+CE L +   +  L  FL  L  +      +ES++KA+A+V F +  Y+ELYSILEN+ F  +NH+ LQ LWY+A Y EA+  RGRPLGAVDKYR+RRK+PLP+TIWDGEETVYCFKE+SR ALKD Y + RYP+P EKR+LAK TGLSLTQVSNWFKNRRQRDR P
Sbjct:   63 LAFSPEQVACVCEALQQGGNVDRLARFLWSLPQSDL-LRGNESILKAQALVAFHQARYQELYSILENHSFSPSNHTFLQDLWYKARYTEAEKARGRPLGAVDKYRIRRKYPLPRTIWDGEETVYCFKERSRNALKDLYNQNRYPSPAEKRNLAKITGLSLTQVSNWFKNRRQRDRNP 238          
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six1b (SIX homeobox 1 [Source:NCBI gene;Acc:101175523])

HSP 1 Score: 227.639 bits (579), Expect = 1.532e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   +  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP+TIWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNLERLGRFLWSLPAC-DHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six2a (SIX homeobox 2 [Source:NCBI gene;Acc:101161260])

HSP 1 Score: 227.639 bits (579), Expect = 1.945e-71
Identity = 106/176 (60.23%), Postives = 130/176 (73.86%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F FT EQ  C+CEVL +   I  L  FL  L        K+ESV+KA+A+V F +GN+RELY ILE+++F  +NH  LQ LW +AHY EA+ +RGRPLGAV KYR+RRKFPLP++IWDGEET YCFKEKSR  L++ Y    YP+P EKR+LA+ TGL+ TQVSNWFKNRRQRDR 
Sbjct:    7 FGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACE-HLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA 181          
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six5 (homeobox protein SIX5 [Source:NCBI gene;Acc:101162386])

HSP 1 Score: 234.187 bits (596), Expect = 2.527e-68
Identity = 104/183 (56.83%), Postives = 138/183 (75.41%), Query Frame = 1
Query:  280 NYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTP 828
            ++++   +F+ +Q  C+CE L++   +  L  FL  +  +      +E+++KA+A+V F +  ++ELY+ILE++ F  +NH  LQ L+ +A Y EA+  RGR LGAVDKYRLR+KFPLPKTIWDGEETVYCFKEKSR ALK+ YK  RYPTP+EK++LAK TGLSLTQVSNWFKNRRQRDRTP
Sbjct:   40 SFQKSALSFSTDQVSCLCEALLQAGNVDRLWRFLSTIPPSSELLRGNETLLKAQALVAFHREEFKELYAILESHDFHPSNHGFLQDLYLKARYKEAERSRGRSLGAVDKYRLRKKFPLPKTIWDGEETVYCFKEKSRNALKECYKSNRYPTPDEKKNLAKVTGLSLTQVSNWFKNRRQRDRTP 222          
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: six9 (homeobox protein six1a-like [Source:NCBI gene;Acc:101162149])

HSP 1 Score: 210.305 bits (534), Expect = 1.042e-65
Identity = 97/174 (55.75%), Postives = 127/174 (72.99%), Query Frame = 1
Query:  304 FTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            FT EQ +C+CEVL++   I  L  FL  +  + +  E+ E V+KA+A V F  G + +LY++LE+  F +++H  LQ LW +A Y EA+  RGRPLGAV KYR+RRKFPLP TIWDGEET+YCFKEKSR+ LK+ Y++  YP+  EKR+LA  TGL+ TQVSNWFKNRRQR+R 
Sbjct:    7 FTPEQVICVCEVLLQAGCIDRLAGFLRTIPPSSSGLEELEGVLKAKAAVAFHHGRFSDLYALLESFPFSSSSHWFLQQLWLRARYTEAERQRGRPLGAVGKYRVRRKFPLPHTIWDGEETIYCFKEKSRRILKEWYRRGPYPSTREKRELAAATGLTATQVSNWFKNRRQRERA 180          
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000029688.1 (SMESG000029688.1)

HSP 1 Score: 692.96 bits (1787), Expect = 0.000e+0
Identity = 331/333 (99.40%), Postives = 331/333 (99.40%), Query Frame = 1
Query:  256 MNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFASFYSPYDFHNSQDRVQNFKSERKYFPYQGLMSSVLMEEPYSQCLNQIKKFNQDSYPSVPGYPSHIGINPFRVSSDAISSELLYEGSNFPGSDNCQGIIPPYYTSLSRAVAPNINNDFNTDLRYLLYSNQPSLDSCIQ 1254
            MNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFASFYSPYDFHNSQDRVQNFKSERKYFPYQGLMSSVLMEEPYSQCLNQIKKFNQDSYPSVPGYPSHIGINPFRVSSDAISSELLYEGSNFPG DNCQ IIPPYYTSLSRAVAPNINNDFNTDLRYLLYSNQPSLDSCIQ
Sbjct:    1 MNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFASFYSPYDFHNSQDRVQNFKSERKYFPYQGLMSSVLMEEPYSQCLNQIKKFNQDSYPSVPGYPSHIGINPFRVSSDAISSELLYEGSNFPGPDNCQAIIPPYYTSLSRAVAPNINNDFNTDLRYLLYSNQPSLDSCIQ 333          
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000005975.1 (SMESG000005975.1)

HSP 1 Score: 228.794 bits (582), Expect = 1.266e-69
Identity = 105/179 (58.66%), Postives = 133/179 (74.30%), Query Frame = 1
Query:  301 AFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQ 837
             FT EQ  C+CEVL +   I  L  FL  L  N    +K+ESV+KA+A+V F +GN++ELY ILE++ F   NH  LQ LW +AHY E++ +RGRPLGAV KYR+R+KFPLP+TIWDG+ET YCFKEKSR  L++ Y +  YPTP EKR+LA+ TGL+ TQVSNWFKNRRQRDR  +N+
Sbjct:  102 GFTQEQVACVCEVLQQGGSIDRLARFLWSL-PNCEYLQKNESVLKAKAVVAFHRGNFKELYRILESHNFSVQNHHKLQDLWLKAHYVESEKIRGRPLGAVGKYRVRKKFPLPRTIWDGDETSYCFKEKSRNVLREWYSQNPYPTPREKRELAEATGLTTTQVSNWFKNRRQRDRASENK 279          
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000001687.1 (SMESG000001687.1)

HSP 1 Score: 207.223 bits (526), Expect = 1.937e-61
Identity = 99/191 (51.83%), Postives = 128/191 (67.02%), Query Frame = 1
Query:  265 QTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHTEFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQ 837
            Q + ++ +     FT EQ  C+CEVL     I  L  F+  L     + + +ESV+ A+A V F + N++ELY ILE+  F  +NH  LQ LW QAHY E + ++GR LGAV KYR+RRK+PLP+TIWDGEET YCFKEKSR  L+  Y    YP+P EK+DLA+ T L+ TQVSNWFKNRRQRDR  +N+
Sbjct:   73 QDSVISPDSGAMGFTQEQVACVCEVLENGGNIDRLALFIWSLPPCQ-QLQTNESVLTAKAAVAFHRQNFKELYRILESYTFSPHNHYKLQALWLQAHYIEEEKIKGRSLGAVAKYRIRRKYPLPRTIWDGEETSYCFKEKSRAVLRQWYLHNPYPSPREKKDLAEMTSLTTTQVSNWFKNRRQRDRAAENK 262          
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000017729.1 (SMESG000017729.1)

HSP 1 Score: 205.297 bits (521), Expect = 1.138e-60
Identity = 93/179 (51.96%), Postives = 125/179 (69.83%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHT---EFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F F  +Q   +CE L +   I  L  FL  + TN        +HE++++ARAIV F  GN+RELY ILE + F+ ++H+ LQ LW +AHY EA+ +RGRPLG VDKYR+R+KFP+P+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA  TGL+ TQV NWFKNRRQRDR 
Sbjct:   38 FQFAPDQIAKVCETLEESGDIERLGRFLWSMPTNSILWKSLNEHEALLRARAIVAFHTGNFRELYHILEKHHFEKSSHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELASATGLTPTQVGNWFKNRRQRDRA 216          
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000017729.1 (SMESG000017729.1)

HSP 1 Score: 205.297 bits (521), Expect = 1.275e-60
Identity = 93/179 (51.96%), Postives = 125/179 (69.83%), Query Frame = 1
Query:  298 FAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHT---EFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAHYDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKDSYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRT 825
            F F  +Q   +CE L +   I  L  FL  + TN        +HE++++ARAIV F  GN+RELY ILE + F+ ++H+ LQ LW +AHY EA+ +RGRPLG VDKYR+R+KFP+P+TIWDGE+  +CFKE++R  L++ Y +  YP P +KR+LA  TGL+ TQV NWFKNRRQRDR 
Sbjct:   45 FQFAPDQIAKVCETLEESGDIERLGRFLWSMPTNSILWKSLNEHEALLRARAIVAFHTGNFRELYHILEKHHFEKSSHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPMPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPAKKRELASATGLTPTQVGNWFKNRRQRDRA 223          
The following BLAST results are available for this feature:
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SIX44.475e-7363.28SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890][more]
SIX22.334e-7159.55SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888][more]
SIX14.348e-7160.23SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887][more]
SIX45.120e-7163.28SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890][more]
SIX52.508e-6759.20SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891][more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ceh-331.731e-5752.00Homeobox protein ceh-33 [Source:UniProtKB/Swiss-P... [more]
ceh-347.935e-5647.94Homeobox protein ceh-34 [Source:UniProtKB/Swiss-P... [more]
ceh-321.841e-4646.15Homeobox protein ceh-32 [Source:UniProtKB/Swiss-P... [more]
unc-391.293e-4241.34Homeobox protein unc-39 [Source:UniProtKB/Swiss-P... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Six43.694e-7360.99gene:FBgn0027364 transcript:FBtr0078274[more]
Six43.694e-7360.99gene:FBgn0027364 transcript:FBtr0078275[more]
so7.518e-7158.47gene:FBgn0003460 transcript:FBtr0088970[more]
Optix1.942e-5149.13gene:FBgn0025360 transcript:FBtr0088865[more]
Optix2.075e-5149.13gene:FBgn0025360 transcript:FBtr0329885[more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six4a4.568e-7562.71SIX homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-010201-2... [more]
six4b1.409e-7463.28SIX homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-010201-1... [more]
six4a3.787e-7262.71SIX homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-010201-2... [more]
six1a1.861e-7160.23SIX homeobox 1a [Source:NCBI gene;Acc:494168][more]
six2b2.023e-7160.23SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-2... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six22.874e-7160.23SIX homeobox 2 [Source:NCBI gene;Acc:100101784][more]
six15.680e-7159.55SIX homeobox 1 [Source:NCBI gene;Acc:100101702][more]
SIX45.322e-7053.88SIX homeobox 4 [Source:NCBI gene;Acc:100498150][more]
tmem1364.044e-5852.05transmembrane protein 136 [Source:Xenbase;Acc:XB-G... [more]
six68.498e-5853.22SIX homeobox 6 [Source:NCBI gene;Acc:100101705][more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Six46.686e-7363.28sine oculis-related homeobox 4 [Source:MGI Symbol;... [more]
Six21.115e-7159.55sine oculis-related homeobox 2 [Source:MGI Symbol;... [more]
Six21.115e-7159.55sine oculis-related homeobox 2 [Source:MGI Symbol;... [more]
Six12.434e-7160.23sine oculis-related homeobox 1 [Source:MGI Symbol;... [more]
Six43.016e-7163.28sine oculis-related homeobox 4 [Source:MGI Symbol;... [more]
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BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q62232|SIX2_MOUSE7.801e-7159.55Homeobox protein SIX2 OS=Mus musculus OX=10090 GN=... [more]
sp|Q9NPC8|SIX2_HUMAN1.121e-7059.55Homeobox protein SIX2 OS=Homo sapiens OX=9606 GN=S... [more]
sp|Q6DHF9|SIX1A_DANRE1.405e-7060.23Homeobox protein six1a OS=Danio rerio OX=7955 GN=s... [more]
sp|Q62231|SIX1_MOUSE1.702e-7060.23Homeobox protein SIX1 OS=Mus musculus OX=10090 GN=... [more]
sp|Q6NZ04|SIX1B_DANRE1.816e-7059.55Homeobox protein six1b OS=Danio rerio OX=7955 GN=s... [more]
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BLAST of Homeobox domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0L8GJ623.807e-8163.27Homeobox domain-containing protein (Fragment) OS=O... [more]
A0A2C9K5V21.710e-8066.11Homeobox domain-containing protein OS=Biomphalaria... [more]
V4AHM75.554e-8065.93Homeobox domain-containing protein OS=Lottia gigan... [more]
A0A1S3HBA66.320e-8068.54homeobox protein six1 OS=Lingula unguis OX=7574 GN... [more]
A0A210R0071.797e-7965.95Homeobox protein SIX4 OS=Mizuhopecten yessoensis O... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six4b2.770e-7558.97homeobox protein SIX4 [Source:NCBI gene;Acc:103035... [more]
six4b5.656e-7558.97homeobox protein SIX4 [Source:NCBI gene;Acc:103035... [more]
ENSAMXT00000021946.21.368e-7361.24homeobox protein six1b [Source:NCBI gene;Acc:10304... [more]
six2b1.179e-7154.29SIX homeobox 2b [Source:ZFIN;Acc:ZDB-GENE-080723-2... [more]
six1b1.891e-7159.55homeobox protein six1b [Source:NCBI gene;Acc:10303... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six1a6.553e-6059.46SIX homeobox 1a [Source:NCBI gene;Acc:494168][more]
ENSPMAT00000002854.13.319e-5649.13pep scaffold:Pmarinus_7.0:GL480305:17375:18769:1 g... [more]
Six44.331e-3079.37pep scaffold:Pmarinus_7.0:GL478660:19078:19268:1 g... [more]
ENSPMAT00000011157.11.629e-2261.90pep scaffold:Pmarinus_7.0:GL488016:7246:7434:-1 ge... [more]
ENSPMAT00000001924.14.464e-1034.09pep scaffold:Pmarinus_7.0:GL488033:11:347:-1 gene:... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO310349.670e-7461.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO343345.279e-7261.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO429335.813e-6555.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO330595.685e-5951.45Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO334077.935e-5753.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
six4a4.149e-7262.15SIX homeobox 4 [Source:NCBI gene;Acc:101159478][more]
six1b1.532e-7160.23SIX homeobox 1 [Source:NCBI gene;Acc:101175523][more]
six2a1.945e-7160.23SIX homeobox 2 [Source:NCBI gene;Acc:101161260][more]
six52.527e-6856.83homeobox protein SIX5 [Source:NCBI gene;Acc:101162... [more]
six91.042e-6555.75homeobox protein six1a-like [Source:NCBI gene;Acc:... [more]
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BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000029688.10.000e+099.40SMESG000029688.1[more]
SMESG000005975.11.266e-6958.66SMESG000005975.1[more]
SMESG000001687.11.937e-6151.83SMESG000001687.1[more]
SMESG000017729.11.138e-6051.96SMESG000017729.1[more]
SMESG000017729.11.275e-6051.96SMESG000017729.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30006682 ID=SMED30006682|Name=Homeobox domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1303bp
CTTAATAATAATAATCAATATCGTCATAATTATCTTTACCAACAATTAAG
AAAATAATTTTATAAACAAAATTTGCATTGATTTTCTAATAAAATTTTCC
GCCAAACAAATGAAATCTCACAGACAAAGTCAAGCGAGCCAATCAGAATC
AAGAGATTCACTCAAATAAAACCGTGTCATTTCAAGCAATAATTATTATT
AGAATATATACATATATATAATTATGTATATATATATATATATCTGACCA
CGTCAATGAATCAGCAAACGAACGCCATGAATTACGAAGAGCGCAAATTT
GCGTTCACGCTCGAGCAAACTGTGTGCATTTGTGAGGTGCTAATCAAGCG
TGAAAAAATCAGTTTACTGGTGAATTTTCTGGACGATCTCGACACTAATC
ACACCGAATTCGAAAAGCACGAGTCAGTAATGAAAGCTCGAGCAATCGTA
TTATTTAAAAAAGGAAATTATCGAGAACTTTATTCAATATTAGAAAACAA
TCGCTTTGACACAAATAATCACAGCACCTTGCAAACTCTTTGGTATCAAG
CCCACTATGATGAAGCGCAAGCGGTCAGAGGTAGGCCGTTGGGAGCAGTG
GACAAGTATCGGTTGAGACGCAAGTTTCCGTTGCCGAAAACCATTTGGGA
CGGGGAAGAAACTGTTTATTGTTTTAAAGAAAAATCTCGACAAGCTCTAA
AAGATTCTTATAAGAAAAAACGATATCCAACTCCAGAAGAAAAGCGAGAC
TTAGCGAAAAAGACAGGCTTATCATTGACGCAAGTGAGCAACTGGTTCAA
AAACAGAAGACAACGAGATCGAACTCCACAAAATCAATTCGCATCATTTT
ATTCTCCGTATGACTTTCACAACAGCCAAGACCGAGTGCAGAATTTCAAG
TCAGAACGAAAGTATTTCCCTTACCAAGGCCTTATGTCTAGCGTGCTGAT
GGAGGAGCCTTATTCGCAATGCTTGAACCAAATCAAGAAGTTCAACCAAG
ATTCCTATCCTTCAGTACCCGGTTACCCTAGTCACATCGGAATCAATCCT
TTTCGTGTTTCTTCTGATGCTATTTCCTCAGAACTCCTTTATGAAGGTTC
AAATTTCCCCGGCTCAGACAACTGCCAAGGAATAATCCCGCCATATTACA
CATCCCTTAGCCGTGCTGTGGCACCAAATATCAACAATGACTTCAATACG
GACCTTCGATATCTATTATACAGTAACCAGCCGAGCCTTGACTCGTGTAT
ACAATAATCATTGCTGATAATAATTAATGATTGTTGTATATAATCAAATG
TAG
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protein sequence of SMED30006682-orf-1

>SMED30006682-orf-1 ID=SMED30006682-orf-1|Name=SMED30006682-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=334bp
MNQQTNAMNYEERKFAFTLEQTVCICEVLIKREKISLLVNFLDDLDTNHT
EFEKHESVMKARAIVLFKKGNYRELYSILENNRFDTNNHSTLQTLWYQAH
YDEAQAVRGRPLGAVDKYRLRRKFPLPKTIWDGEETVYCFKEKSRQALKD
SYKKKRYPTPEEKRDLAKKTGLSLTQVSNWFKNRRQRDRTPQNQFASFYS
PYDFHNSQDRVQNFKSERKYFPYQGLMSSVLMEEPYSQCLNQIKKFNQDS
YPSVPGYPSHIGINPFRVSSDAISSELLYEGSNFPGSDNCQGIIPPYYTS
LSRAVAPNINNDFNTDLRYLLYSNQPSLDSCIQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR001356Homeobox_dom
IPR031701SIX1_SD
IPR009057Homeobox-like_sf
IPR017970Homeobox_CS
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0043565sequence-specific DNA binding
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001356Homeobox domainSMARTSM00389HOX_1coord: 133..195
e-value: 7.5E-16
score: 68.7
IPR001356Homeobox domainPFAMPF00046Homeodomaincoord: 139..189
e-value: 1.6E-14
score: 53.4
IPR001356Homeobox domainPROSITEPS50071HOMEOBOX_2coord: 140..191
score: 15.046
IPR001356Homeobox domainCDDcd00086homeodomaincoord: 138..192
e-value: 2.13872E-15
score: 67.6536
NoneNo IPR availableGENE3DG3DSA:1.10.10.60coord: 138..196
e-value: 4.6E-17
score: 63.2
NoneNo IPR availablePANTHERPTHR10390:SF64SIX HOMEOBOX 4A-RELATEDcoord: 15..197
NoneNo IPR availablePANTHERPTHR10390HOMEOBOX PROTEIN SIXcoord: 15..197
IPR031701Homeobox protein SIX1, N-terminal SD domainPFAMPF16878SIX1_SDcoord: 17..128
e-value: 5.5E-42
score: 142.8
IPR017970Homeobox, conserved sitePROSITEPS00027HOMEOBOX_1coord: 166..189
IPR009057Homeobox-like domain superfamilySUPERFAMILYSSF46689Homeodomain-likecoord: 131..196