Alpha-mannosidase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30006606 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8Note: Hover over icons to view figure legend
Homology
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2B1 (mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826]) HSP 1 Score: 702.975 bits (1813), Expect = 0.000e+0 Identity = 399/984 (40.55%), Postives = 572/984 (58.13%), Query Frame = 2
Query: 125 GYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRK--DINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL----------SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLV--PITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS-KDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK------NTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
GY +C +PN+LNVH++ HTHDDVGWLKTVDQY+YG +++IQ AGVQYIL++VISAL +P R+F YVEIA+F RWW QQ + + V+ LV +GRL+F GGW MNDEA THY +I+DQM+LGL FL TFG GRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK R+ ME + + S LFT VL + Y P C+D C D P+++DP +YN ++ VD F + Q + Y+TNH ++ MG DFQ++NAN F NLDKLI VN K ++V YSTPACY +NK +K+DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + LN+ M V QHHDAVSGT +QHVA DYA++L+ G CE +++++L++L F C LNIS C +S + V++YNPLG ++ W R+PV+ + + NG VPS +V P ++ H P EL F + LPALG+++ ++ + + ++ S + I N++++ T+ D G L+ + N+ + + + Q +Y + G+ Q SGAYIFRP + +P+++ ++ ++K LV EVHQ FS W V RLY LE EW+VGPIP+ D+ GKE++ ++ T +++ F+TDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + N + L + TDR+ G S ++G +E+MVHRR L DD GV EPL E +G+G VRG+ + D + RL + + P VV + N Q+S L +LP V++L+L + + +++Q E+ + LN + +F + IT + E L ANQ + RLKW N+ +Q + + +TL P +IRTF
Sbjct: 51 GYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNE-------AMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARL---RGFKDHFTFCQQLNISICPLSQTAAR---FQVIVYNPLG-RKVNWMVRLPVS---EGVFVVKDPNGRTVPSDVVIFPSSDSQAHPP----------ELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQ-----LTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLME---NGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTF 999
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2B1 (mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826]) HSP 1 Score: 701.434 bits (1809), Expect = 0.000e+0 Identity = 398/985 (40.41%), Postives = 572/985 (58.07%), Query Frame = 2
Query: 125 GYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL----------SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLV--PITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS-KDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK------NTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
GY +C +PN+LNVH++ HTHDDVGWLKTVDQY+YG +++IQ AGVQYIL++VISAL +P R+F YVEIA+F RWW QQ + + V+ LV +GRL+F GGW MNDEA THY +I+DQM+LGL FL TFG GRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK R+ ME + + S LFT VL + Y P C+D C D P+++DP +YN ++ VD F + Q + Y+TNH ++ MG DFQ++NAN F NLDKLI VN + ++V YSTPACY +NK +K+DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + LN+ M V QHHDAVSGT +QHVA DYA++L+ G CE +++++L++L F C LNIS C +S + V++YNPLG ++ W R+PV+ + + NG VPS +V P ++ H P EL F + LPALG+++ ++ + + ++ S + I N++++ T+ D G L+ + N+ + + + Q +Y + G+ Q SGAYIFRP + +P+++ ++ ++K LV EVHQ FS W V RLY LE EW+VGPIP+ D+ GKE++ ++ T +++ F+TDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + N + L + TDR+ G S ++G +E+MVHRR L DD GV EPL E +G+G VRG+ + D + RL + + P VV + N Q+S L +LP V++L+L + + +++Q E+ + LN + +F + IT + E L ANQ + RLKW N+ +Q + + +TL P +IRTF
Sbjct: 51 GYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNE-------AMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARL---RGFKDHFTFCQQLNISICPLSQTAAR---FQVIVYNPLG-RKVNWMVRLPVS---EGVFVVKDPNGRTVPSDVVIFPSSDSQAHPP----------ELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQ-----LTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLME---NGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTF 1000
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2B2 (mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623]) HSP 1 Score: 255.373 bits (651), Expect = 3.657e-70 Identity = 278/1058 (26.28%), Postives = 455/1058 (43.01%), Query Frame = 2
Query: 125 GYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRN-RVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYD-SYCTPPGFCFDDKCS---------DDPIMDD--PTLHDYNVQKRVDDFADYV---IKQSKA-YQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD--INVFYSTPACYTLAXXXXXXX-XXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQL--HVLSQQNRTDLN-----KKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS--------KDKIVIGNKYLK----------LTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQ-KSGA----YIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSE-------WGMIVTRLY-----NDSNIL----ETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTL--FDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVF----SKNTNISKFDQYSALLDNLPSGVN--ILSL----------ENHFNL----NNEIDYQIIRVENVFYQ---------FGHSIKLNFQKMFRSI-KITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQM-----IVTLFPGQIRTFKI 2989
G S P + ++ H+H DVGW+ TV + Y N+ +V+ L R+F VE +F WW S + +V+ L+ EGRL+F++GG M+DEA TH I Q++ G FL +TFG RP SW +DPFG S +FA GF+ R+DY K + ++F+ +GS ++ +FT+++ SYCTP F ++ P D P + + ++ +A+ + +KQ A ++T H+L P GCD QF NA+ F N+D L+ H+N + ++V Y+T Y A++ + + DF PY++ P WTG++TSRS+LKG + ++ + + + L R L+ +++ + + QHHDA++GTE V YA L+ G+ ++ S VL L + A S + +YNPL T + V +++ G VPSQ I N T E+ + Y+L + +P L Y IR + S + + +YL L D + S+ QSN +V +TQ+ + Y NG K G Y+F P ++P +A ++ I+ G LVTE+ Q F I +RL +D +L E E+ GP+ +N +E VL+ T+++S ++D+NG Q+ +R Y +A NYYP+ F+ ++ K LV+ ++RA G+ S NG +E+M+HRR FD + G LN+T +V W+ + + +L + +RPVV+F + Q A+ LP ++ ILS+ E+ NL E + RV Y + +N + + +++ + V E +L+ L + R W + ++ TS I+T+ P +IRTF I
Sbjct: 20 GVQSAGP-----IRAFVVPHSHMDVGWVYTVQESMRAYAANV--------YTSVVEELARGQQRRFIAVEQEFFRLWWDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSE-RQEIFTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDGVYPNMSEPVTPANINLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFANMDPLLDHINSHAAELGVSVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHLASGMLGMRKLMAS--------------IVLDELQPQAPMAASSDAGPAGHFAS-VYNPLAWTVTTIVTLTVGF---PGVRVTDEAGHPVPSQ---IQNST--------ETPSAYDLLILTTIPGLSYRHYN-IRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHAGRYLVPVANDCYIVLLDQDTNLMHSIWERQSNRTVRVTQE---FLEYHVNGDVKQGPISDNYLFTP-GKAAVPAWEAVEMEIVAGQLVTEIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQM------QRRPYVSYVNNSIARNYYPMVQSAFM-----EDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTS------VVHPVLWLLLGSWSLTTALRQRSALALQHRPVVLFGDLAGTAPKLPGPQQQEAV--TLPPNLHLQILSIPGWRYSSNHTEHSQNLRKGHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWDLSMLHRWSWRTGPGRHRGDTTSPSRPPGGPIITVHPKEIRTFFI 1004
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 253.447 bits (646), Expect = 4.185e-69 Identity = 226/848 (26.65%), Postives = 384/848 (45.28%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF---LPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQF---QNANHNFVNLDKLI-FHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXX--------XDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL--SQQNRTDLNKK-------IISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI--SKETVNYD----FVLCNLLNISFCAISDNISY---TKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQL-VPITNCTKHLPERPKESLANYELTFQSVLPAL------------GYASLTII-------RXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMR-YYFSYQGNGQKSGAYIFRPTTNESMPLT--KAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGP-IPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNE 2497
L V ++ H+H+D GW+KT D+YY Q+ILN+++S L E+P R+F + E+++F +WW + R V+ LV G+L+ GGW M DEA +HY ++IDQ+ G +L + G P W +DPFG+S + + R+ Y K+ AT ++EF+ + ++ T I ++ YD C P P C FD K ++ P + + NV +R D K+S+ +++N LLVP+G DF++ Q + F N +L F +R + + T + Y A+ K + DFF YA + YWTGY+TSR K + + + L+ L + R+ L + +++ A + +G+ QHHDA++GT K+ V DY RL L + + VI + L+ KET ++D F+ + +S A+ + + V+++NPL R + VN ++ G + Q+ ++ T+ +P+ Y+++ LPAL G+ +L R + + + N+Y+++ + + S + + DM+ + + + KSGAY+F P E+ P + P L + +G +EV + V RLYN + + + I D KE+ L TDIDS FFTD NG Q+ R+ K+ P+ N+YP+ ++ ++ +K L +HT +A GV S K+G +E+++ RR + DDN G+G+ L +
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGAT--PRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVN---SPRVRVLSEEGQPLAVQISAHWSSATEAVPD-------VYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLP-DGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAV-RLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRYLKKL--------PLQANFYPMPVMAYI-----QDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKD 978
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 253.447 bits (646), Expect = 4.185e-69 Identity = 226/848 (26.65%), Postives = 384/848 (45.28%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF---LPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQF---QNANHNFVNLDKLI-FHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXX--------XDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL--SQQNRTDLNKK-------IISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI--SKETVNYD----FVLCNLLNISFCAISDNISY---TKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQL-VPITNCTKHLPERPKESLANYELTFQSVLPAL------------GYASLTII-------RXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMR-YYFSYQGNGQKSGAYIFRPTTNESMPLT--KAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGP-IPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNE 2497
L V ++ H+H+D GW+KT D+YY Q+ILN+++S L E+P R+F + E+++F +WW + R V+ LV G+L+ GGW M DEA +HY ++IDQ+ G +L + G P W +DPFG+S + + R+ Y K+ AT ++EF+ + ++ T I ++ YD C P P C FD K ++ P + + NV +R D K+S+ +++N LLVP+G DF++ Q + F N +L F +R + + T + Y A+ K + DFF YA + YWTGY+TSR K + + + L+ L + R+ L + +++ A + +G+ QHHDA++GT K+ V DY RL L + + VI + L+ KET ++D F+ + +S A+ + + V+++NPL R + VN ++ G + Q+ ++ T+ +P+ Y+++ LPAL G+ +L R + + + N+Y+++ + + S + + DM+ + + + KSGAY+F P E+ P + P L + +G +EV + V RLYN + + + I D KE+ L TDIDS FFTD NG Q+ R+ K+ P+ N+YP+ ++ ++ +K L +HT +A GV S K+G +E+++ RR + DDN G+G+ L +
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGAT--PRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVN---SPRVRVLSEEGQPLAVQISAHWSSATEAVPD-------VYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLP-DGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAV-RLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRYLKKL--------PLQANFYPMPVMAYI-----QDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKD 978
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 615.92 bits (1587), Expect = 0.000e+0 Identity = 369/959 (38.48%), Postives = 559/959 (58.29%), Query Frame = 2
Query: 68 VSLIINILFFG---IYSSPTTCGYNSCNP--GKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLY-DSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNR-LRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK----IVIGNKYLKLTYDN-GFXXXXXXXXXXXXXXITQDMRYYFSYQG----NGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIP--INDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFD---QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFY-QFGHSIK-LNFQKMFRSIKITEVIELNLSANQFL 2875
++L + LF G IYSS C +N+C+ PNV+ H+I HTHDD+GW+KTVDQY++G + + GVQYI NTVI L +NP+R+FS+ E + +RW+ R++++ LV G+++ + GGW NDEAT+HYV IIDQM+LGL L + FGECG+P+ WQIDPFGHS E ANI+ MG+ ++F R+ Y +K+ R+ K +EF+ S T N LFT + D+Y P GFC+D C DDPIMD+ + YNV+++VD F D+V Q+ TN +++ MG DFQ+ NAN +VNLDKLI +VN K + V YSTPACYT A+ L +K+DDFFPYASG +SYWTGYFTSR A KG ++ ++ + Q+ KQL V++ D + I + + QHHDAV+GT K++V DY ++L+ G+S+ E VIN + K+ + + ++ VLC L+N + C I+ + +V+I+N G RIP + + +H N ++ SQ+V T + + YE+ +P LGY ++ + + + N++ K + I N+YL +D+ G+L ++ + +I Q+ +F Y+G + Q SGAYIFRP T + + LT L ++ G ++ EV Q S + RL N +E EW VGPIP + KE V +Y T++ S N FTDSNGRQ + R + T + ++ TEP+AGNYYP+ S ++ K+ + TDRA G+ + +G++EIM+HRR +DD+FGV E L+E G DG GL+ GK + F + S++R ++ F++PV+ F+KN +F+ +YS L LP G+++L+LE ++ +IR EN+++ + G+SIK + +F + I EL L AN+ +
Sbjct: 1 MNLQVIFLFLGLLVIYSS-QDCAWNTCHKVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITD--NKLFTGAFFNDNYGPPEGFCWDSLCGDDPIMDNLNIEGYNVKEKVDAFVDHVKNQAAHQSTNQVMLLMGSDFQYTNANSWYVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMIRQASCMLQLAKQLDVIANLGPED-DSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKM-NPDGLDPKLVLCPLINETICK---PINGSSEFSVVIFNSNGRYFNGTIRIPYSQKTA-VLRDAHKN--VLESQIVE----TFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFVEK-------GSKPERVHFNNRKKFNTNVEIQNEYLIAGFDSQGYLSYITEKATKKKRSIRQE---FFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEVVPGAIINEVRQKVSPFVSQQIRLPRGKNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYI-----KDENAQFSVITDRAQGMVA-SDGVVEIMLHRRCFYDDHFGVEEALDEPGKDGAGLVAMGKHIVLFTDVKASTSQLRPLAIDNFHQPVLAFNKNPEKFEFNRLLEYSGLKFELPIGIHLLTLEKWHKKSS-----LIRFENIYHGEEGNSIKEFDPTHIFTNFDIVSFKELLLGANRVV 923
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 615.92 bits (1587), Expect = 0.000e+0 Identity = 369/959 (38.48%), Postives = 559/959 (58.29%), Query Frame = 2
Query: 68 VSLIINILFFG---IYSSPTTCGYNSCNP--GKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLY-DSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNR-LRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK----IVIGNKYLKLTYDN-GFXXXXXXXXXXXXXXITQDMRYYFSYQG----NGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIP--INDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFD---QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFY-QFGHSIK-LNFQKMFRSIKITEVIELNLSANQFL 2875
++L + LF G IYSS C +N+C+ PNV+ H+I HTHDD+GW+KTVDQY++G + + GVQYI NTVI L +NP+R+FS+ E + +RW+ R++++ LV G+++ + GGW NDEAT+HYV IIDQM+LGL L + FGECG+P+ WQIDPFGHS E ANI+ MG+ ++F R+ Y +K+ R+ K +EF+ S T N LFT + D+Y P GFC+D C DDPIMD+ + YNV+++VD F D+V Q+ TN +++ MG DFQ+ NAN +VNLDKLI +VN K + V YSTPACYT A+ L +K+DDFFPYASG +SYWTGYFTSR A KG ++ ++ + Q+ KQL V++ D + I + + QHHDAV+GT K++V DY ++L+ G+S+ E VIN + K+ + + ++ VLC L+N + C I+ + +V+I+N G RIP + + +H N ++ SQ+V T + + YE+ +P LGY ++ + + + N++ K + I N+YL +D+ G+L ++ + +I Q+ +F Y+G + Q SGAYIFRP T + + LT L ++ G ++ EV Q S + RL N +E EW VGPIP + KE V +Y T++ S N FTDSNGRQ + R + T + ++ TEP+AGNYYP+ S ++ K+ + TDRA G+ + +G++EIM+HRR +DD+FGV E L+E G DG GL+ GK + F + S++R ++ F++PV+ F+KN +F+ +YS L LP G+++L+LE ++ +IR EN+++ + G+SIK + +F + I EL L AN+ +
Sbjct: 1 MNLQVIFLFLGLLVIYSS-QDCAWNTCHKVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITD--NKLFTGAFFNDNYGPPEGFCWDSLCGDDPIMDNLNIEGYNVKEKVDAFVDHVKNQAAHQSTNQVMLLMGSDFQYTNANSWYVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMIRQASCMLQLAKQLDVIANLGPED-DSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKM-NPDGLDPKLVLCPLINETICK---PINGSSEFSVVIFNSNGRYFNGTIRIPYSQKTA-VLRDAHKN--VLESQIVE----TFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFVEK-------GSKPERVHFNNRKKFNTNVEIQNEYLIAGFDSQGYLSYITEKATKKKRSIRQE---FFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEVVPGAIINEVRQKVSPFVSQQIRLPRGKNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYI-----KDENAQFSVITDRAQGMVA-SDGVVEIMLHRRCFYDDHFGVEEALDEPGKDGAGLVAMGKHIVLFTDVKASTSQLRPLAIDNFHQPVLAFNKNPEKFEFNRLLEYSGLKFELPIGIHLLTLEKWHKKSS-----LIRFENIYHGEEGNSIKEFDPTHIFTNFDIVSFKELLLGANRVV 923
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 615.92 bits (1587), Expect = 0.000e+0 Identity = 369/959 (38.48%), Postives = 559/959 (58.29%), Query Frame = 2
Query: 68 VSLIINILFFG---IYSSPTTCGYNSCNP--GKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLY-DSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNR-LRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK----IVIGNKYLKLTYDN-GFXXXXXXXXXXXXXXITQDMRYYFSYQG----NGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIP--INDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFD---QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFY-QFGHSIK-LNFQKMFRSIKITEVIELNLSANQFL 2875
++L + LF G IYSS C +N+C+ PNV+ H+I HTHDD+GW+KTVDQY++G + + GVQYI NTVI L +NP+R+FS+ E + +RW+ R++++ LV G+++ + GGW NDEAT+HYV IIDQM+LGL L + FGECG+P+ WQIDPFGHS E ANI+ MG+ ++F R+ Y +K+ R+ K +EF+ S T N LFT + D+Y P GFC+D C DDPIMD+ + YNV+++VD F D+V Q+ TN +++ MG DFQ+ NAN +VNLDKLI +VN K + V YSTPACYT A+ L +K+DDFFPYASG +SYWTGYFTSR A KG ++ ++ + Q+ KQL V++ D + I + + QHHDAV+GT K++V DY ++L+ G+S+ E VIN + K+ + + ++ VLC L+N + C I+ + +V+I+N G RIP + + +H N ++ SQ+V T + + YE+ +P LGY ++ + + + N++ K + I N+YL +D+ G+L ++ + +I Q+ +F Y+G + Q SGAYIFRP T + + LT L ++ G ++ EV Q S + RL N +E EW VGPIP + KE V +Y T++ S N FTDSNGRQ + R + T + ++ TEP+AGNYYP+ S ++ K+ + TDRA G+ + +G++EIM+HRR +DD+FGV E L+E G DG GL+ GK + F + S++R ++ F++PV+ F+KN +F+ +YS L LP G+++L+LE ++ +IR EN+++ + G+SIK + +F + I EL L AN+ +
Sbjct: 1 MNLQVIFLFLGLLVIYSS-QDCAWNTCHKVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITD--NKLFTGAFFNDNYGPPEGFCWDSLCGDDPIMDNLNIEGYNVKEKVDAFVDHVKNQAAHQSTNQVMLLMGSDFQYTNANSWYVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMIRQASCMLQLAKQLDVIANLGPED-DSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKM-NPDGLDPKLVLCPLINETICK---PINGSSEFSVVIFNSNGRYFNGTIRIPYSQKTA-VLRDAHKN--VLESQIVE----TFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFVEK-------GSKPERVHFNNRKKFNTNVEIQNEYLIAGFDSQGYLSYITEKATKKKRSIRQE---FFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEVVPGAIINEVRQKVSPFVSQQIRLPRGKNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYI-----KDENAQFSVITDRAQGMVA-SDGVVEIMLHRRCFYDDHFGVEEALDEPGKDGAGLVAMGKHIVLFTDVKASTSQLRPLAIDNFHQPVLAFNKNPEKFEFNRLLEYSGLKFELPIGIHLLTLEKWHKKSS-----LIRFENIYHGEEGNSIKEFDPTHIFTNFDIVSFKELLLGANRVV 923
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-2 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q2PJ74]) HSP 1 Score: 224.557 bits (571), Expect = 5.799e-60 Identity = 208/831 (25.03%), Postives = 380/831 (45.73%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVL----YD--SYCTP-PGFC--FDDK------CSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQ---NANHNFVNLDKLIFHVNRLRK-DINVFYSTPACY----TLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSR---SALKGFVQYSNNVFQVCKQLHVLSQQNRTDLN--KKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLAN--YELTFQSVLPALGYASLTIIRXXXXXXXX---------XXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQ-----GNGQK---SGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIP---------INDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGV 2479
L V +I H+H D GW+ T ++YY NI L+ + L E +F Y EI++F WW+ Q ++ +VK + G+ + + GGW M DEA HY S+I ++ G +++ G+ P W IDPFG S ++ S R+ Y K + KN+EF + F T H L ++++ YD C P P C FD + S D + ++D NV R + D K+S+ ++ N + P+G DF++ N + N KL ++N + +++ + T + Y AI+ G++L + DFF YA + YW+GYFTSR L +Q+ ++ L + ++ + +K+++ + + QHHD V+GT K HV DY Q++ D L+ CE +++ +L L+ ++ N + + +N + + + Y V+++N L R E I V+ L ++ + Q+ P+ + E+ + N +EL F L + S ++++ ++ K ++ K+ ++ + N ++ +D NG + ++L + +++ +Y + + NG + +GAY+F P ++ ++KG++V +V + ND IL+T +P + + E+ L++ + ++S + FFTD NG Q+I R+ + P N+YP+++ V++ + + + IH+ +A GV S +G IEIM+ RR DDN G+
Sbjct: 181 LEVIVIPHSHCDPGWIMTFEEYYNRQTRNI--------LDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTG-HPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVEAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGIDSTNKMQMDEHRVNENL--LPEKRVYKIGQNVVLFNTLSRNRNEPICIQVDSLDAG----VEADPPIKKQQVSPVIAYDE---EKKTLVVKNGIFELCFMLSLGPMESVSFRLVKNTTTSKVEIITNNAAEFKETSFKSSSTSGDFTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKVFATPN----------NDLKILQTYTLYQGLPWIDLDNEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKRRRQTKL--------PTQANFYPMSAGVYIEDDTTR-----MSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNRGL 970
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-3 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:O01574]) HSP 1 Score: 136.346 bits (342), Expect = 2.810e-32 Identity = 121/456 (26.54%), Postives = 196/456 (42.98%), Query Frame = 2
Query: 95 FGIYSSPTTCGYNSCNPG----KPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDK---CSDD---------PIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQ-----NANH-NFVNLDKLIFHVNRLR----------KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALK--GFVQYS--NNVFQVCKQLHVLSQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRL 1351
F ++ S G N+ P + L V+++ TH D GWL+T ++Y IL+ + + +N +F + E +F RWW Q+ V+ VK LV EGRL+ G W M DEA ++ +D + G F++K FG +P W DPFG+S +F G R+ ++ K+ + K + F + F T + L T +L ++ C D C D P + + NV + + + + K S+ Y+ +L+ G DF+F N H NF+ + I +R+ D+ +YS + + DFFPY YWTGY+T+R K G + +S N + L V +Q + N K + A + + + QHHDA++GT K V +Y++ L
Sbjct: 112 FDLFESVVAKG-NTLPPASKKSRTEKLKVYVLPFTHVDPGWLETFERY---------TKSTNQILDNMHQFMMKNEKMRFMWAEFVFFERWWSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDNIVEGFQFIHKNFG--IKPQTMWSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFKWRQYFDATGEDDVL-TQILPYTHYDILNSCGSDASVCCEFDFKRMTHWSCPGPKPEKITNANVAAKAEKLVNQLEKMSEMYKAPVILMMHGDDFRFDMIEEWNQQHDNFIPVFDEINKGSRVEIRFGTFTDYFNDLEKWYSN---------NKDSEPPTVSGDFFPYMCALGDYWTGYYTTRPFFKRQGRLLHSLIRNGDIMLSMLRVNLKQRKIGENVKRLEAARRNLALFQHHDAITGTSKVSVMDNYSELL 545
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: LManII (gene:FBgn0027611 transcript:FBtr0080030) HSP 1 Score: 717.998 bits (1852), Expect = 0.000e+0 Identity = 408/992 (41.13%), Postives = 580/992 (58.47%), Query Frame = 2
Query: 29 AKL*NFIMAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI--SKETVN-------YDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSV-LPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD-NGFXXXXXXXXXXXXXXITQDMRYYFSYQGN-----GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFD--------YIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDN--------LPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW 2899
AK +++ F + LI + I + CGY SC+P KPN+LNVH+++HTHDDVGWLKTVDQYYYG IQ AGVQYI+++V+ AL +P ++F YVE A+F++WW++Q V+ VK+LV +GRL+F+ G W MNDEATTHY S+IDQ S GL LN TFGECGRP V WQIDPFGHS E A++FA MGFDG+FF RLDY+DK++R+ TKN E I GS + + LF+ LY++Y P GFCFD C+D PI+D D NV++R+D F D+ QS+ Y+TN+++V MG DF +Q A + NLDKLI + N + +IN+ YSTP+CY +++ G K+DDFFPYAS P++YWTGYFTSR LK F + N+ QVCKQL L+ + + + + M +G+ QHHDA++GTEK+ VA DYA+R+S C + ++L++L SK+ V ++F C LLNI+ C +S+ + +YNPL T E+ RIPV Y+I + G + SQ VPI + R S A YE+ F + +PALGY + + + + T+S + S VIGN +++L +D NGF ++ ++Q+ +Y GN + SGAYIFRP N+ T ++ + KGDLV EVHQ F++W V R+YN + E EW VGPIPI+D GKE++ ++ +DI SD F TDSNGR++I R+IN R ++ E VAGNYYP+ + +++ ++ + I TDRA G S K+G +E+MVHRR L DD FGVGE LNET G+GLI RGK + F + I +LE L P F N D++ N LP V++L+LE + ++ I + ++ N + + + + + E L N +L + +RL++
Sbjct: 3 AKTSVWLVFFCALGCLIHDADLRSIQPKASQCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEAD-LFSGALYNNYQAPDGFCFDILCNDAPIIDGKHSPDNNVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEA---NDRFALTLYNPLAHTVNEYVRIPVPY---SNYRIIDNKGVTLESQAVPIPQVLIDIKHR--NSTAKYEIVFLATNIPALGYRTYYVEKLDSTEGNTRSKALPKRTSS-VTVIGNSHIQLGFDTNGF--LSEVTADGLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITT-----KIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEY-GDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKL----LPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQF 972
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: LManII (gene:FBgn0027611 transcript:FBtr0080031) HSP 1 Score: 714.531 bits (1843), Expect = 0.000e+0 Identity = 406/992 (40.93%), Postives = 581/992 (58.57%), Query Frame = 2
Query: 29 AKL*NFIMAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI--SKETVN-------YDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSV-LPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD-NGFXXXXXXXXXXXXXXITQDMRYYFSYQGN-----GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFD--------YIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDN--------LPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW 2899
AK +++ F + LI + I + CGY SC+P KPN+LNVH+++HTHDDVGWLKTVDQYYYG IQ AGVQYI+++V+ AL +P ++F YVE A+F++WW++Q V+ VK+LV +GRL+F+ G W MNDEATTHY S+IDQ S GL LN TFGECGRP V WQIDPFGHS E A++FA MGFDG+FF RLDY+DK++R+ TKN E I GS + + LF+ LY++Y P GFCFD C+D PI+D D NV++RVD F YV + ++ ++T ++++ MG DF +QNA+ + NLDKLI + N + +IN+ YSTP+CY +++ G K+DDFFPYAS P++YWTGYFTSR LK F + N+ QVCKQL L+ + + + + M +G+ QHHDA++GTEK+ VA DYA+R+S C + ++L++L SK+ V ++F C LLNI+ C +S+ + +YNPL T E+ RIPV Y+I + G + SQ VPI + R S A YE+ F + +PALGY + + + + T+S + S VIGN +++L +D NGF ++ ++Q+ +Y GN + SGAYIFRP N+ T ++ + KGDLV EVHQ F++W V R+YN + E EW VGPIPI+D GKE++ ++ +DI SD F TDSNGR++I R+IN R ++ E VAGNYYP+ + +++ ++ + I TDRA G S K+G +E+MVHRR L DD FGVGE LNET G+GLI RGK + F + I +LE L P F N D++ N LP V++L+LE + ++ I + ++ N + + + + + E L N +L + +RL++
Sbjct: 3 AKTSVWLVFFCALGCLIHDADLRSIQPKASQCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEAD-LFSGALYNNYQAPDGFCFDILCNDAPIIDGKHSPDNNVKERVDAFLAYVTEMAEHFRTPNVILTMGEDFHYQNADMWYKNLDKLIKYGNERQANGSNINLLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEA---NDRFALTLYNPLAHTVNEYVRIPVPY---SNYRIIDNKGVTLESQAVPIPQVLIDIKHR--NSTAKYEIVFLATNIPALGYRTYYVEKLDSTEGNTRSKALPKRTSS-VTVIGNSHIQLGFDTNGF--LSEVTADGLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITT-----KIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEY-GDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKL----LPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQF 972
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: LManV (gene:FBgn0032068 transcript:FBtr0079742) HSP 1 Score: 672.929 bits (1735), Expect = 0.000e+0 Identity = 403/1009 (39.94%), Postives = 589/1009 (58.37%), Query Frame = 2
Query: 50 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSK----DKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTK-APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFT-QTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPV-VVFSKNTNISKFDQYSA-LLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQ----NFFTSN-------------QMIVTLFPGQIRTFKI 2989
M F+ +V L + L S+ CGY SC+ K N++N+H++ H+HDDVGWLKTVDQYYYG+R+NIQ AGVQYI++TVIS L +NP+R+F VE ++F +WW +Q T+R VK+LVNEGRLQF+ G W MNDEA +Y S+IDQ ++GL FL+ TFG CGRP V WQIDPFGHS EQA+I+A MGFDG FF R+D+ DK +R+ +E I S +++ LFT +LY Y PGFCFD CSDDPI+D + +D NV+ RVDDF Y + ++ ++TNH+++PMG DFQ+++A N+ N+DKLI +VN + N+ YSTP CY +++K + K DFFPY S NS+WTGY+TSR K F + N++ QV KQL ++ + T + + + MGV QHHDA++GTEKQHV+ DY + L D + +L KL + N +F C LNIS CA + + + ++T +YN L T ++ R+PV + Y+++ G +V S++VP+ L R +S +EL F++ + + + + SK+S++ + + N++ ++ ++ +KL DN + + VS NI Q Y +Y SGAY+FR + + + T+ G LV EVHQ FSE+ V R+ D +E EW VGPIP+ + G E+V + ++I S+ F+TDSNGR++I R+ +KR D+ +P +GNYYP+ S + L + N K L I DRA G S K+G IE+M+HRR + DD +GVGE LNE G LI RGK ++ + D S R E+ K F+ P+ FSKNT + S D+ P V++L+LE FN ++EI ++RVEN G + N + +F + E+ E L N L D+K+ K+++ + ++TS+ + VTL+P QIRTF I
Sbjct: 1 MKFLGIV-LCVAFLALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLSQVK--LFTGLLYTFYWDTPGFCFDVHCSDDPIIDSDS-YDNNVKSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKLTN--LPNGEFESCLQLNISECAFTKDGADNVVVT--LYNALAHTTKQYVRVPVK---NENYQVTDEKGRVVASEIVPVPAEVLALEFR--DSDTQHELVFKASVDKIANYYIKKVDSKESSNGVRVISQPKANAETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQSYGLYRTYD-----SGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSN-----KRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKY-GQPLIARGKVFLILNAADESTSAER-EAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDDFPKSVHLLTLEP-FN-DDEI---LLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFII 979
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: LManV (gene:FBgn0032068 transcript:FBtr0345752) HSP 1 Score: 672.929 bits (1735), Expect = 0.000e+0 Identity = 403/1009 (39.94%), Postives = 589/1009 (58.37%), Query Frame = 2
Query: 50 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSK----DKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTK-APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFT-QTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPV-VVFSKNTNISKFDQYSA-LLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQ----NFFTSN-------------QMIVTLFPGQIRTFKI 2989
M F+ +V L + L S+ CGY SC+ K N++N+H++ H+HDDVGWLKTVDQYYYG+R+NIQ AGVQYI++TVIS L +NP+R+F VE ++F +WW +Q T+R VK+LVNEGRLQF+ G W MNDEA +Y S+IDQ ++GL FL+ TFG CGRP V WQIDPFGHS EQA+I+A MGFDG FF R+D+ DK +R+ +E I S +++ LFT +LY Y PGFCFD CSDDPI+D + +D NV+ RVDDF Y + ++ ++TNH+++PMG DFQ+++A N+ N+DKLI +VN + N+ YSTP CY +++K + K DFFPY S NS+WTGY+TSR K F + N++ QV KQL ++ + T + + + MGV QHHDA++GTEKQHV+ DY + L D + +L KL + N +F C LNIS CA + + + ++T +YN L T ++ R+PV + Y+++ G +V S++VP+ L R +S +EL F++ + + + + SK+S++ + + N++ ++ ++ +KL DN + + VS NI Q Y +Y SGAY+FR + + + T+ G LV EVHQ FSE+ V R+ D +E EW VGPIP+ + G E+V + ++I S+ F+TDSNGR++I R+ +KR D+ +P +GNYYP+ S + L + N K L I DRA G S K+G IE+M+HRR + DD +GVGE LNE G LI RGK ++ + D S R E+ K F+ P+ FSKNT + S D+ P V++L+LE FN ++EI ++RVEN G + N + +F + E+ E L N L D+K+ K+++ + ++TS+ + VTL+P QIRTF I
Sbjct: 1 MKFLGIV-LCVAFLALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLSQVK--LFTGLLYTFYWDTPGFCFDVHCSDDPIIDSDS-YDNNVKSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKLTN--LPNGEFESCLQLNISECAFTKDGADNVVVT--LYNALAHTTKQYVRVPVK---NENYQVTDEKGRVVASEIVPVPAEVLALEFR--DSDTQHELVFKASVDKIANYYIKKVDSKESSNGVRVISQPKANAETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQSYGLYRTYD-----SGAYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSN-----KRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKY-GQPLIARGKVFLILNAADESTSAER-EAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDDFPKSVHLLTLEP-FN-DDEI---LLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFII 979
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: LManVI (gene:FBgn0032069 transcript:FBtr0079741) HSP 1 Score: 657.522 bits (1695), Expect = 0.000e+0 Identity = 397/1034 (38.39%), Postives = 584/1034 (56.48%), Query Frame = 2
Query: 50 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPIT----------NCTKH--LPERPKESLANY---ELTFQSVLPALGY-----------ASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLT-KAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYN-FTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPV-VVFSKNTNISKFDQYSA-LLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVF-YQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQ----NFFTS-------------NQMIVTLFPGQIRTFKIVSK 2998
M ++ + L + +L + S CGY +C K N++N+H++ H+HDDVGWLKTVDQY+YG+R NIQ AGVQYI++TVI+ L ++P R+F VE ++F +WW +Q T + V+ LVNEGRL+F G W MNDEA +Y S+IDQ +LGL FL+ TFG C RP + WQIDPFGHS EQA+IFA MG+DG FF R+D+RDK RI ME I S + ++ +FT +LY Y PPG+CFD C DDPI+D + +D NV+ RVDDF YV ++ Y++NH+++PMG DFQ+++A NF N+DKLI +VN + + N+FYSTPACY ++++ + K DFFPY S NSYWTGYFTSR K F + N++ QV KQL V ++ N + + + MGV QHHDA++GTEKQHV+ DY + L D + + L KL + N +F C LNIS CA + + + ++T +YNPL T ++ R+PV + Y+++ G +V S++VP+ N T+H + + + +ANY ++ Q + A+L + + K K++T + + + V+ +KL DN + + + VS NI Q Y +Y SGAY+FR + + + T+ G LV EVHQ FSE+ V R+Y N++E EW VGPI + G+E+V+ + + I SD +TDSNGR++I R ++R + +P A NYYPV S + L ++ KK + + DRA G S NG +E+M+HRR + DD +GVGE LNE G +I RGK ++ D + R E+ K + P FSKNT + S ++ P V++L+LE FN ++E+ ++RVEN + G + N + +F + E+ E L N L D+KR K++ + + +FTS ++ VTL P QIRTF I ++
Sbjct: 1 MKYLCGIVLFVALLAISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWWAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDAS--DSLSNDEIFTGLLYRHYSAPPGYCFDVHCGDDPIIDTKS-YDNNVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYEDAQVNFKNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAELNTKQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKLTN--LPNGEFESCLQLNISECAFTKDDADNVVVT--LYNPLAHTSTQYVRVPVK---NENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVEMNGVSENIDQSYGVYRTYD-----SGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIYEGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIAL-----QDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNEEKY-GQPMIARGKVYLILSPSDESTAAER-EAEKEIHLPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLEP-FN-DDEV---LLRVENFLDHTEGQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQIRTFIIKTE 1007
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 773.467 bits (1996), Expect = 0.000e+0 Identity = 433/988 (43.83%), Postives = 604/988 (61.13%), Query Frame = 2
Query: 101 IYSSPT----TCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTD---LNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKI--VIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGNG----QKSGAYIFRPTTNESMPLTKAPKLTIIK-GDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFD-QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHS------IKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
++S PT CGY SC KP++LNVH++ HTHDDVGWLKTVDQY+YG R+NIQ AGVQYIL++VI L ++P R+F YVE A+FYRWW+QQ+ R V LVNEGRL+F+ GGWCM+DEATTHY ++IDQM+LGL FLN TFGECGRP V+W IDPFGH+ E A+IFA MG+DG FF RLDY+DK++R+ TK ME + + S T LFT VL + Y P GFC+D C D PI DDP L DYNV + V F + KQ+ Y+TNH+++ MG DFQ++NAN + N+DKLI +VN L+ +NV YSTP+CY +N +K DDFFPYA + +WTGYFTSR ALK + + SN+ Q C QL VL T +M MGVAQHHDAVSGTEKQHVA DYA+RL+ G + CE ++++SL+ L E V C LNIS C ++++ + ++ +YNPLG T + W R+PVN G Y ++ +NG V S+++P++ K + R A EL FQ P LGY++ I SK+ + I NK+LK+T+D+ G L SL+NL++ ++ +TQ+ +Y + GN Q SGAYIFRP +++ ++K ++ + + V EV Q FS W V RLY D LE EWTVGP+P+ D GKE++ + TDI S F+TDSNGR+++ R+ + R ++ QTEP+AGNYYP+NS ++ K+ K+ L + TDR+ G S NG +EIM+HRR L+DD GVGEPL+E G +GL+ RG+ + + R + + +P++ F ++S L LP V++L++ + D ++R+E+ YQ S + +N QK+F ++++ E++L ANQ+ +D+ RL WN T+ + VTL P +IRTF
Sbjct: 20 VFSLPTGRNSICGYKSCPATKPSMLNVHLVPHTHDDVGWLKTVDQYFYGDRNNIQHAGVQYILDSVIDQLQKDPARRFIYVETAFFYRWWRQQNQNTRRIVTQLVNEGRLEFINGGWCMSDEATTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDKDRRMKTKEMEMLWRASESLTPPIADLFTGVLPNGYNPPEGFCWDQSCDDAPIRDDPDLEDYNVDEIVQKFLNASHKQADYYKTNHIIMTMGSDFQYENANLWYKNMDKLIKYVNALQAKGSKLNVLYSTPSCYLQELNLANFTWPMKTDDFFPYADDAHDFWTGYFTSRPALKLYERLSNSRLQTCNQLEVLGGPTSTSGPFGEGDSDTMRRAMGVAQHHDAVSGTEKQHVANDYARRLATGWAHCEVLVSNSLAVLSGSEAPR---VFCENLNISVCPLTES---SHKFSMNVYNPLGRT-VRWPVRLPVN---GSVYNVTDANGKAVDSEVIPLSKSRKEV--RQNRGFAKSELVFQVEAPPLGYSTYII--------SMVQDQPPVSRSKNAVPSSIQNKFLKVTFDSTTGLLSSLTNLETQQTIRLTQNFFWYNASAGNNKESHQPSGAYIFRPNSSDPFIISKTAEIQAVSLYNSVQEVTQRFSPWVSQVVRLYEDRRELELEWTVGPVPVEDGLGKEVITRLDTDIQSSGYFYTDSNGREVLERRKDYRPTWDLKQTEPIAGNYYPINSRAYI-----KDDKRQLTVVTDRSQGASSIYNGSLEIMLHRRLLYDDFRGVGEPLSEPGEFAHGLVARGRLLLTLSPPEAAADLHRPLAQSMVLQPLLSFQDGAPSPGTKLEFSGLQAALPPAVHLLTVSQW-----DQDSVLVRLEHQ-YQAKESKTHSQPVTVNLQKLFSTLQVLGASEMSLGANQWKEDMIRLHWN-TDALPPTARDPSSWEVTLKPMEIRTF 975
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 288.886 bits (738), Expect = 8.642e-90 Identity = 138/236 (58.47%), Postives = 173/236 (73.31%), Query Frame = 2
Query: 101 IYSSPT----TCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCS 796
++S PT CGY SC KP++LNVH++ HTHDDVGWLKTVDQY+YG R+NIQ AGVQYIL++VI L ++P R+F YVE A+FYRWW+QQ+ R V LVNEGRL+F+ GGWCM+DEATTHY ++IDQM+LGL FLN TFGECGRP V+W IDPFGH+ E A+IFA MG+DG FF RLDY+DK++R+ TK ME + + S T LFT L G+C D+ +
Sbjct: 20 VFSLPTGRNSICGYKSCPATKPSMLNVHLVPHTHDDVGWLKTVDQYFYGDRNNIQHAGVQYILDSVIDQLQKDPARRFIYVETAFFYRWWRQQNQNTRRIVTQLVNEGRLEFINGGWCMSDEATTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDKDRRMKTKEMEMLWRASESLTPPIADLFTGHL---EFINGGWCMSDEAT 252
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:ZFIN;Acc:ZDB-GENE-110331-1]) HSP 1 Score: 263.077 bits (671), Expect = 1.810e-72 Identity = 235/857 (27.42%), Postives = 395/857 (46.09%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF---LPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNA---NHNFVNLDKLIFHVN-RLRKDINVFYSTPACY--------TLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSR-----------SALKGF-VQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCN--LLNISFCAISDNISYTKLLT-------VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKL---TYDN------------GFXXXXXXXXXXXXXXITQDMRYYFSYQGNG-----QKSGAYIFRPTTNESMPLTK--APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNI--LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGN 2515
L V ++ H+H+D GW+KT D+YY N Q Q+ILN +++ + E+P RKF + EI+YF +WW+ D + ++ L+ G+L+ + GGW M DEA HY ++IDQ+ G +L + G P W +DPFGHS + + R+ Y K+ AT+++EF+ + ++ T + ++ YD C P P C FD K ++ P ++D NV +R D K+SK +++ LLVP+G DF++ A + ++N KL ++N + ++T + Y + + + DFF YA + YW+GY+TSR S L+G + YS V H + + +++ A + +G+ QHHDA++GT K+ V DY RL L + VI ++ LI K Y F L A D++ L+ ++++NP+ R+ + VN ++ +G +P QL + S Y+ +F + LPALG A + S S +S T+ + + + + G L + T D GF + L+S + Q++R + G KSGAY+F P N + P ++ AP + +++G L EV + + V R++N + L + T + I D KE+ +++ TDI S + F+TD NG QI R+ + Q P+ N+YP+ S ++ ++ + L +HT +A GV S +G +E+++ RR + DDN G+G+ L + N
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYY-----NDQ---TQHILNNMVTKMAEDPRRKFIWSEISYFAKWWESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVT--PRSGWAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRKKSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQFATLSDYFDAVYKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYS---LAVAHARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINAAHFLIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESSPRYLVLFNPVEQERLCLVTVLVN---SARVRVLTEDGQTLPVQLSAQWMSATEM------SGEVYQASFMARLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSLTLGFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGN-AKPYSQREAPIVRVVEGPLFAEVVAHYQHFQQTV-RIHNVPGVDGLSLDITTM-VDIRDQNNKELAMRFVTDIQSGDTFYTDLNGFQIQPRR--------YFQKLPLQANFYPMPSTAYI-----QDSQYRLTLHTAQALGVTSLASGQLEVILDRRLMQDDNRGLGQGLKDNKRTAN 984
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:ZFIN;Acc:ZDB-GENE-110331-1]) HSP 1 Score: 263.077 bits (671), Expect = 1.810e-72 Identity = 235/857 (27.42%), Postives = 395/857 (46.09%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF---LPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNA---NHNFVNLDKLIFHVN-RLRKDINVFYSTPACY--------TLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSR-----------SALKGF-VQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCN--LLNISFCAISDNISYTKLLT-------VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKL---TYDN------------GFXXXXXXXXXXXXXXITQDMRYYFSYQGNG-----QKSGAYIFRPTTNESMPLTK--APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNI--LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGN 2515
L V ++ H+H+D GW+KT D+YY N Q Q+ILN +++ + E+P RKF + EI+YF +WW+ D + ++ L+ G+L+ + GGW M DEA HY ++IDQ+ G +L + G P W +DPFGHS + + R+ Y K+ AT+++EF+ + ++ T + ++ YD C P P C FD K ++ P ++D NV +R D K+SK +++ LLVP+G DF++ A + ++N KL ++N + ++T + Y + + + DFF YA + YW+GY+TSR S L+G + YS V H + + +++ A + +G+ QHHDA++GT K+ V DY RL L + VI ++ LI K Y F L A D++ L+ ++++NP+ R+ + VN ++ +G +P QL + S Y+ +F + LPALG A + S S +S T+ + + + + G L + T D GF + L+S + Q++R + G KSGAY+F P N + P ++ AP + +++G L EV + + V R++N + L + T + I D KE+ +++ TDI S + F+TD NG QI R+ + Q P+ N+YP+ S ++ ++ + L +HT +A GV S +G +E+++ RR + DDN G+G+ L + N
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYY-----NDQ---TQHILNNMVTKMAEDPRRKFIWSEISYFAKWWESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVT--PRSGWAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRKKSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQFATLSDYFDAVYKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYS---LAVAHARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINAAHFLIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESSPRYLVLFNPVEQERLCLVTVLVN---SARVRVLTEDGQTLPVQLSAQWMSATEM------SGEVYQASFMARLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSLTLGFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGN-AKPYSQREAPIVRVVEGPLFAEVVAHYQHFQQTV-RIHNVPGVDGLSLDITTM-VDIRDQNNKELAMRFVTDIQSGDTFYTDLNGFQIQPRR--------YFQKLPLQANFYPMPSTAYI-----QDSQYRLTLHTAQALGVTSLASGQLEVILDRRLMQDDNRGLGQGLKDNKRTAN 984
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2b2 (mannosidase, alpha, class 2B, member 2 [Source:ZFIN;Acc:ZDB-GENE-140106-166]) HSP 1 Score: 254.218 bits (648), Expect = 5.379e-70 Identity = 267/1045 (25.55%), Postives = 466/1045 (44.59%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTV-RNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPT-KIHNYLFTNVLYD-SYCTPPGFCFDDKCS---------DDPIMDD--PTLHDYNVQKRVDDFADYVIK----QSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD--INVFYSTPACY-TLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTD-------LNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXI----------------NSKDKIVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQ-KSGA----YIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVF-------SEWGMIVTRL------YNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDN-------------LPSGVNILSLE--------NHFNLNNE-----IDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSI-KITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTS------NQMIVTLFPGQIRTFKI 2989
+ +I H+H DVGW+ TV + + Y N+ +TV+ L NRKF VE +F WW S + +V+ L+ EGRL+F++GG M+DEA T I Q++ G FL +TFG RP +W +DPFG S +FA GFD R+DY K+ K ++F+ +GS PT K +FT+ + SYCTP F ++ DP D P + ++ V+ +A ++ +++ ++++H+L P GCD QF NA+ F N+D L+ ++N + V Y+T Y N DF PY++ P WTG++ SR+ LKG + ++++ + L + D K+ ++ + QHHD ++GTE VA Y + L G+ E ++ + + +T++ D + + N A +D+ + + + +YNPL + + V + +G VP+Q+ P ES Y+L F L L Y T+ + + ++ + + + N+ KL +D L S+++ + V + QD ++ Y+ NG +SG YIF ++P K+ + I+ G +++E+ Q F + +VTR+ LE + VGP+ +N +E V + +T + ++ FTD+NG Q++ KRT Y VA NYYP+ ++ + +++ +V ++RA GV S G +E+M+HRR + + G N T D + +VR W+ D++ S + E++++ +RPVV+ DQ LL+ LP +++ SL H + +E D ++R+ +++ + +N +++ + I K+++V E +L+ + D++R W T++ Q S VT+ P +IRTF I
Sbjct: 23 IQAFVIPHSHMDVGWVYTVQESMHAYASNV--------YSTVVEELTRVKNRKFIAVEQEFFRLWWTNVASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVTDVDDAILQLTEGHGFLYETFGV--RPRFAWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDDMQKNKKLQFVWRGS--PTLKEKQEIFTHTMDQFSYCTPSYIPFSNRSGFYWNGVALFPDPPKDGKYPNMSLPVTKETVELYAQTMVDNIRLRAQWFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYINTHSDQYGVTVQYATLKDYFQTLHQTNLSWDVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRASSLLYASESLFTRYHISYPDGPVQREWALSKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGMMGAEELL---AAIFLLPQTLSND-IYDQIKNTPTTARTDSENVPE-QHIFVYNPLAWNISTYVNVSVQYAMA---VVLDDDGKAVPAQIQP-----------SMESSTVYDLFFVVELGGLQYRKYTVQFPQSPCDTGSACGATHVAKVVKFNKTNVRQWKKTGRKLLPVLNECYKLMFDQETNLLHSITDRSKKIRVRVQQD---FWEYKANGDVQSGPISDNYIFT-ANGSAVPAYKSVVMEIVPGKVISEIRQYFYREEEDANHTYSVVTRVPVGFKGRLSCFRLEQSYKVGPLEVN----RETVFRTRTSLQNNRTLFTDNNGYQMM-----KRT-YKGYANNTVARNYYPMVRVAYMEDESSR-----VVFLSERAHGVASLSQGQLEVMLHRRLWNNQEWNQG--YNLTLNDSS--VVRPVLWMMLGSPDSLSSIYQQEAVELQHRPVVM--------AIDQPQKLLNQRETFSGPSVHPVVLPQNLHMQSLSIPGWNYSPEHSSGGDEKSEVNFDRILLRITHLYEEGESPVLSQPTTINLKEVMQGIGKVSKVQECSLTGTWNISDLQRWNWK-TDETMQKTDKSGFSGVTQDFNVTISPKEIRTFFI 1004
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: tnnc1 (troponin C1, slow skeletal and cardiac type [Source:Xenbase;Acc:XB-GENE-480515]) HSP 1 Score: 419.853 bits (1078), Expect = 3.807e-132 Identity = 199/366 (54.37%), Postives = 256/366 (69.95%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS 1222
SC LNVH+I HTH+DVGWLKTVDQYYYG ++IQ AGVQYIL++V+S L +P+++F YVE A+F+RWW+QQD VR V LV EGRL+F+ GGW MNDEA THY SIIDQM+LGL FL TFG+CGRP V+W IDPFGHS EQA +FA MG+DG FF RLDY+DK R TK ME + + S + + LFT VL + Y P GFC+D C D PI+DDP++ DYN V F +Q++ Y ++H+++ MG DFQ++NA F N+D+LI +VN + +NVFYSTP+CY ++++ +K DDFFPYA GP+ +WTGYFTSR A KG+ + SNN QVC Q+ LS
Sbjct: 22 SCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALS 387 HSP 2 Score: 234.572 bits (597), Expect = 2.499e-64 Identity = 129/347 (37.18%), Postives = 193/347 (55.62%), Query Frame = 2
Query: 1907 ITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-----GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNS 2905
+ Q +Y + GN Q SGAYIFRP ++S+P+++ + +++ LV EVHQ FS W V RLY D +E EWTVGP+PI D GKE++ +T++ +D F+TDSNGRQI+ R+ + R + QTEP+AGNYYPVNS +++ K + + + TDR+ G S ++G +E+MVHRR L DD GVGEPL E G G G++VRG+ + D+ D R +L+ + P VV S I + ++SAL LP ++L+ H D ++R+E+ F I +N +F S+ ++ E L AN +KRL+W +
Sbjct: 434 LKQSFYWYNASVGNEESSQPSGAYIFRPNNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLNQTEPIAGNYYPVNSRIYI-----KGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMH-----AADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKRLQWRT 770
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: tnnc1 (troponin C1, slow skeletal and cardiac type [Source:Xenbase;Acc:XB-GENE-480515]) HSP 1 Score: 419.468 bits (1077), Expect = 3.947e-132 Identity = 199/366 (54.37%), Postives = 256/366 (69.95%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS 1222
SC LNVH+I HTH+DVGWLKTVDQYYYG ++IQ AGVQYIL++V+S L +P+++F YVE A+F+RWW+QQD VR V LV EGRL+F+ GGW MNDEA THY SIIDQM+LGL FL TFG+CGRP V+W IDPFGHS EQA +FA MG+DG FF RLDY+DK R TK ME + + S + + LFT VL + Y P GFC+D C D PI+DDP++ DYN V F +Q++ Y ++H+++ MG DFQ++NA F N+D+LI +VN + +NVFYSTP+CY ++++ +K DDFFPYA GP+ +WTGYFTSR A KG+ + SNN QVC Q+ LS
Sbjct: 22 SCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALS 387 HSP 2 Score: 219.164 bits (557), Expect = 3.669e-59 Identity = 117/298 (39.26%), Postives = 173/298 (58.05%), Query Frame = 2
Query: 1907 ITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVF 2773
+ Q +Y + GN Q SGAYIFRP ++S+P+++ + +++ LV EVHQ FS W V RLY D +E EWTVGP+PI D GKE++ +T++ +D F+TDSNGRQI+ R+ + R + QTEP+AGNYYPVNS +++ K + + + TDR+ G S ++G +E+MVHRR L DD GVGEPL E G G G++VRG+ + D+ D R +L+ + P VV S I + ++SAL LP ++L+ H D ++R+E+ F
Sbjct: 430 LKQSFYWYNASVGNEESSQPSGAYIFRPNNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLNQTEPIAGNYYPVNSRIYI-----KGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMH-----AADKILLRLEHPF 717
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: tnnc1 (troponin C1, slow skeletal and cardiac type [Source:Xenbase;Acc:XB-GENE-480515]) HSP 1 Score: 420.239 bits (1079), Expect = 5.166e-132 Identity = 199/366 (54.37%), Postives = 256/366 (69.95%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS 1222
SC LNVH+I HTH+DVGWLKTVDQYYYG ++IQ AGVQYIL++V+S L +P+++F YVE A+F+RWW+QQD VR V LV EGRL+F+ GGW MNDEA THY SIIDQM+LGL FL TFG+CGRP V+W IDPFGHS EQA +FA MG+DG FF RLDY+DK R TK ME + + S + + LFT VL + Y P GFC+D C D PI+DDP++ DYN V F +Q++ Y ++H+++ MG DFQ++NA F N+D+LI +VN + +NVFYSTP+CY ++++ +K DDFFPYA GP+ +WTGYFTSR A KG+ + SNN QVC Q+ LS
Sbjct: 22 SCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALS 387 HSP 2 Score: 235.728 bits (600), Expect = 1.286e-64 Identity = 136/375 (36.27%), Postives = 209/375 (55.73%), Query Frame = 2
Query: 1829 NKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-----GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNS 2905
N+Y ++ +D G + + NL+ +S+ + Q +Y + GN Q SGAYIFRP ++S+P+++ + +++ LV EVHQ FS W V RLY D +E EWTVGP+PI D GKE++ +T++ +D F+TDSNGRQI+ R+ + R + QTEP+AGNYYPVNS +++ K + + + TDR+ G S ++G +E+MVHRR L DD GVGEPL E G G G++VRG+ + D+ D R +L+ + P VV S I + ++SAL LP ++L+ H D ++R+E+ F I +N +F S+ ++ E L AN +KRL+W +
Sbjct: 429 NRYYRVDFDPETGLISGIHNLEKKISLPLKQSFYWYNASVGNEESSQPSGAYIFRPNNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLNQTEPIAGNYYPVNSRIYI-----KGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMH-----AADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKRLQWRT 793
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: tnnc1 (troponin C1, slow skeletal and cardiac type [Source:Xenbase;Acc:XB-GENE-480515]) HSP 1 Score: 426.017 bits (1094), Expect = 5.632e-132 Identity = 201/370 (54.32%), Postives = 258/370 (69.73%), Query Frame = 2
Query: 122 CGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS 1222
CG SC LNVH+I HTH+DVGWLKTVDQYYYG ++IQ AGVQYIL++V+S L +P+++F YVE A+F+RWW+QQD VR V LV EGRL+F+ GGW MNDEA THY SIIDQM+LGL FL TFG+CGRP V+W IDPFGHS EQA +FA MG+DG FF RLDY+DK R TK ME + + S + + LFT VL + Y P GFC+D C D PI+DDP++ DYN V F +Q++ Y ++H+++ MG DFQ++NA F N+D+LI +VN + +NVFYSTP+CY ++++ +K DDFFPYA GP+ +WTGYFTSR A KG+ + SNN QVC Q+ LS
Sbjct: 26 CGEQSCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALS 395 HSP 2 Score: 241.506 bits (615), Expect = 1.439e-65 Identity = 137/378 (36.24%), Postives = 205/378 (54.23%), Query Frame = 2
Query: 1907 ITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-----GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIV-----TLFPGQIRTF 2983
+ Q +Y + GN Q SGAYIFRP ++S+P+++ + +++ LV EVHQ FS W V RLY D +E EWTVGP+PI D GKE++ +T++ +D F+TDSNGRQI+ R+ + R + QTEP+AGNYYPVNS +++ K + + + TDR+ G S ++G +E+MVHRR L DD GVGEPL E G G G++VRG+ + D+ D R +L+ + P VV S I + ++SAL LP ++L+ H D ++R+E+ F I +N +F S+ ++ E L AN +KRL+W + + + +V TL P +IRTF
Sbjct: 616 LKQSFYWYNASVGNEESSQPSGAYIFRPNNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLNQTEPIAGNYYPVNSRIYI-----KGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMH-----AADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKRLQWRTRTGSPLQMDSPRAPVVDPSNITLSPMEIRTF 983
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: tnnc1 (troponin C1, slow skeletal and cardiac type [Source:Xenbase;Acc:XB-GENE-480515]) HSP 1 Score: 420.239 bits (1079), Expect = 6.696e-132 Identity = 199/366 (54.37%), Postives = 256/366 (69.95%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS 1222
SC LNVH+I HTH+DVGWLKTVDQYYYG ++IQ AGVQYIL++V+S L +P+++F YVE A+F+RWW+QQD VR V LV EGRL+F+ GGW MNDEA THY SIIDQM+LGL FL TFG+CGRP V+W IDPFGHS EQA +FA MG+DG FF RLDY+DK R TK ME + + S + + LFT VL + Y P GFC+D C D PI+DDP++ DYN V F +Q++ Y ++H+++ MG DFQ++NA F N+D+LI +VN + +NVFYSTP+CY ++++ +K DDFFPYA GP+ +WTGYFTSR A KG+ + SNN QVC Q+ LS
Sbjct: 22 SCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEALS 387 HSP 2 Score: 227.639 bits (579), Expect = 8.413e-62 Identity = 129/347 (37.18%), Postives = 189/347 (54.47%), Query Frame = 2
Query: 1907 ITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQF-----GHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNS 2905
+ Q +Y + GN Q SGAYIFRP ++S+P+++ LV EVHQ FS W V RLY D +E EWTVGP+PI D GKE++ +T++ +D F+TDSNGRQI+ R+ + R + QTEP+AGNYYPVNS +++ K + + + TDR+ G S ++G +E+MVHRR L DD GVGEPL E G G G++VRG+ + D+ D R +L+ + P VV S I + ++SAL LP ++L+ H D ++R+E+ F I +N +F S+ ++ E L AN +KRL+W +
Sbjct: 469 LKQSFYWYNASVGNEESSQPSGAYIFRPNNSDSVPVSQ-------HNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLNQTEPIAGNYYPVNSRIYI-----KGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMH-----AADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKRLQWRT 798
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2b1 (mannosidase 2, alpha B1 [Source:MGI Symbol;Acc:MGI:107286]) HSP 1 Score: 679.093 bits (1751), Expect = 0.000e+0 Identity = 400/999 (40.04%), Postives = 577/999 (57.76%), Query Frame = 2
Query: 74 LIINILFFGIYSSP--TTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL--SQQNRTDLNK-KIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPV---NVLHGDEY-KISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK--IVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFS------KNTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
L I+ LF+ + ++P GY +C P KP +LNVH++ HTHDDVGWLKTVDQYYYG ++Q A VQYIL++V+S+L E P R+F YVE+A+F RWW+QQ S ++ V+ LV +GRL+F+ GGW MNDEA THY +I+DQM+LGL FL TFG G P V+W IDPFGHS EQA++FA MGFDG F R+DY+DK R ME + + S LFT VL ++Y P C+D C+D P++D+P ++N + V+ F Q Y+TNH ++ MG DF ++NAN F N+DKLI VN + + ++V YSTP CY +NK +K DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + N + M V QHHDAVSGT +Q+V DYA++L+ G CE +++++L++L S N+ F C LNIS C +S ++ V +YNPLG + R+PV N + D + K SN +VPS +EL F + +PALG+++ ++ + N + + K +VI NKY++ T+D+ G L+ + NL+ N+S+ ++Q +Y + G+ Q SGAYIFRP + +P+++ +++++K LV EVHQ FS W V RLY LE EWTVGPIP+ D GKE++ ++ T + + FFTDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + + L + TDR+ G S ++G +E+MVHRR L DD+ GV EPL ET G VRG+ + + + ++ RL + + P VV S ++ + Q+S L LP V++L+L L +++Q E+ + LN Q +F++ I + E L+ANQ L RLKW N+ +Y + VTL P +IRTF
Sbjct: 32 LPISFLFWLLLAAPGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARL-SHYKQNFSF--CRELNISICPVSQT---SERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYY---------------SETYQWELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYIT-----DGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLET---DTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTF 1001
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a2 (mannosidase 2, alpha 2 [Source:MGI Symbol;Acc:MGI:2150656]) HSP 1 Score: 265.774 bits (678), Expect = 2.518e-73 Identity = 236/855 (27.60%), Postives = 392/855 (45.85%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK---GSFLPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQF---QNANHNFVNLDKLI--------FHVNRLRKDINVFYSTPACYT---LAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLH--VLSQQNRTDLNKK-------IISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI--SKETVNYD----FVLCNLLNISFCAISDNISYTKLLT----VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQL-VPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXIN-------------------SKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSY--QGNGQKSGAYIFRPTTNESMPLT--KAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNI----LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNE 2497
L V ++ H+H+D GW+KT D+YY Q+ILN+++S L E+P R+F + E+++F +WW + R V+ LV G+L+ GGW M DEA +HY +++DQ+ G +L + G P W +DPFGHS + + R+ Y K+ AT ++EF+ + S T I ++ YD C P P C FD K ++ P + + NV R D K+S+ +++N LLVP+G DF++ Q + F N +L FHV ++ ++ A Y + + + DFF YA + YWTGY+TSR K + + + L+ L+ R+ L + +++ A + +G+ QHHDA++GT K+ V DY RL L + VI ++ L+ +ET ++D F+ + +S A+ + + +L + V+++NPL R+ + VN ++ G + Q+ V ++ T +P+ Y+++ LP LG L + +SS +N I N+Y+++ + +G L +++ Q + Y + + KSGAY+F P + E+ P K P L + +G +EV V+ E V RLYN + L+ + V I D KE+ L+ TDIDS FFTD NG QI RQ K+ P+ N+YP+ ++ ++ ++ L +HT +A GV S NG +E+++ RR + DDN G+G+ L +
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGAT--PRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPEFHVQAQFGTLSEYFD--ALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILYSLALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALPER-TVIRLDSSPRFVVVFNPLEQERLSVVSLLVN---SPRVRVLSEEGQPLSVQISVHWSSATDMVPD-------VYQVSVPVRLPGLGLGVLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGASDFAISNRYMQVWF-SGLTGLLKSIRRVDEEQEQQMELEFLVYGTRTSKDKSGAYLFLPDS-EAKPYVPKKPPVLRVTEGPFFSEV-AVYYEHFHQVIRLYNLPGVEGLSLDMSFQVD---IRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKL--------PLQANFYPMPVMAYI-----QDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKD 978
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a1 (mannosidase 2, alpha 1 [Source:MGI Symbol;Acc:MGI:104669]) HSP 1 Score: 251.521 bits (641), Expect = 1.236e-68 Identity = 231/849 (27.21%), Postives = 370/849 (43.58%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK-----GSFLPTKIHNYLFTNVLYDSYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANH---NFVNLDKLIFHVN-RLRKDINVFYSTPACYTLAXXXXXXXXXXXXD--------DFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLH--VLSQQNRTDLNK--------KIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYD------FVLCNLLNISFCAISDNI----SYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXX---------------XXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLT--KAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIP-INDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGN 2515
L V ++ H+H+D GWLKT + Y+ RD QYI N ++ L E+ +RKF + EI+Y +WW D + VK L+ G+L+ + GGW M DEAT HY ++IDQ+ G +L K G +P W IDPFGHS A + GF + R+ Y K+ K +EF + GS H F + C P P C FD K P + NVQ R D K+SK ++T LL P+G DF+F N ++L ++N + + + + T + Y A+ K K + DFF YA + YW+GYFTSR K + + + + L+ L Q + +NK + +G+ QHHDA++GT K V DY RL L+ E +I S LI K+ Y F+ + S ++ I S + +++YNP R I VN K+ +G V Q+ + N + + S A YE++F + +P LG I+ S+ S+S +++ D I I N +L + +D L+ + + + + ++ KSGAY+F P + P + P + + +G + ++V F E RLYN I V I I + +EIV++ + I++ N ++TD NG QI R+ + P+ N YP+ + ++ + ++ L + + ++ G S +G IE+ + RR + DDN G+G+ +++ N
Sbjct: 165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFMWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGV--KPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIRVN---SATVKVLSDSGKPVEVQVSAVWNDMRTI------SQAAYEVSFLAHIPPLGLKVFKILESQSSSSHLADYVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFDRSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPD-GQGQPYVSLRPPFVRVTRGRIYSDV-TCFLEHVTHKVRLYNIQGIEGQSMEVSNIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQIQPRRTMSKL--------PLQANVYPMCTMAYIQDAEHR-----LTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITAN 979
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2b2 (mannosidase 2, alpha B2 [Source:MGI Symbol;Acc:MGI:1195262]) HSP 1 Score: 242.662 bits (618), Expect = 4.679e-66 Identity = 263/1054 (24.95%), Postives = 461/1054 (43.74%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWW-----QQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPT-KIHNYLFTNVL-YDSYCTPPGFCFDDKCS---------DDPIMDD--PTLHDYNVQKRVDDFADYV---IKQSKA-YQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD--INVFYSTPACYTLAXXXXXXX-XXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-------SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINS-SLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS---------------KDKIVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGN-----GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGM-------IVTRLYNDS-------NILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK--NTNISKFDQYSALLDNLPSGVN--ILSLE---------NHF-NLNN--------EIDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSI-KITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQM-----IVTLFPGQIRTFKI 2989
+ P P + ++ H+H DVGW+ TV + Y N+ TV++ L R+F VE +F WW +QQ VR L++EGRL+F+LGG M+DEA TH I Q++ G FL +TFG RP SW +DPFG S +FA GF+ R+DY K+ + ++F+ GS P+ +FT+V+ + SYCTP F ++ +P D P + + + +A+ + +KQ A ++T H+L P GCD QF NA+ F N+D L+ ++N+ I+V Y+T Y A++ + DF PY+S P WTG++TSRS LKG + ++ + + + + T +++ + + QHHDA++GTE V Y + L G+ ++ S +L T ++ + + + Y + +YNPL W + L ++ N S+ P++ ++ + P + Y+L + +P L Y ++ ++ + T+ N+ K + + N L +D L S+ + QSN +V +TQ+ + YQ N G S Y+F P N + P +A + ++ G LVT++ Q F + I TRL + S +E ++ VGP+ +N +E +L+ +D++S ++D+NG Q+ +R Y ++ P+ NYYP+ F+ ++ K LV+ +R GV S NG +E+M+HRR +N N T D + IV W+ + + + + + PVV+ + + ++ LP ++ ILS+ H NL + ++R+ +++ ++ + + R + + V E +L+ ++ ++R W++ D+ + TS I+T++P +IRTF I
Sbjct: 20 AAQPAGP--IRAFVVPHSHMDVGWVFTVQESMRAYAANV--------YTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQ----LLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGS--PSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLMVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVGY----SASVYNPLA-----WKITTIITL-----TVAFPNVSVTDELGHPVSTQIQNSTKDP----SAYDLLILTTIPGLNYRHYQVMHARGDQAGTRELVAPRANTLKFSLKLRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQE---FLEYQANWDVKQGPISDNYLFAP-NNTAEPSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPLDLN----REAILRTSSDLNSQQVLYSDNNGYQM------QRRPYKAFKSNPIPRNYYPMVQSAFI-----EDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLW--NNLAWDLKYNLTLNDTS--IVHPVLWLMLGPKSTMTALHPRSGVALQHGPVVLLKELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVAVEERSLTGTWDVQMLQRWHWSTKTDHLKGHPTSPPRPPGGSIITVYPKEIRTFFI 1014
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a2 (mannosidase 2, alpha 2 [Source:MGI Symbol;Acc:MGI:2150656]) HSP 1 Score: 163.31 bits (412), Expect = 1.298e-41 Identity = 110/360 (30.56%), Postives = 172/360 (47.78%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK---GSFLPTKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQF---QNANHNFVNLDKLI--------FHVNRLRKDINVFYSTPACYT-LAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALK 1162
L V ++ H+H+D GW+KT D+YY Q+ILN+++S L E+P R+F + E+++F +WW + R V+ LV G+L+ GGW M DEA +HY +++DQ+ G +L + G P W +DPFGHS + + R+ Y K+ AT ++EF+ + S T I ++ YD C P P C FD K ++ P + + NV R D K+S+ +++N LLVP+G DF++ Q + F N +L FHV ++ ++ T + + + DFF YA + YWTGY+TSR K
Sbjct: 166 LQVFVVPHSHNDPGWIKTFDKYYT--------EQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGAT--PRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYK 515
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|Q29451|MA2B1_BOVIN (Lysosomal alpha-mannosidase OS=Bos taurus OX=9913 GN=MAN2B1 PE=1 SV=4) HSP 1 Score: 714.531 bits (1843), Expect = 0.000e+0 Identity = 412/1000 (41.20%), Postives = 579/1000 (57.90%), Query Frame = 2
Query: 80 INILFFGIYSSPTT--CGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD----INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS----------QQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI------SKFDQYSALLDNLPSGVNILSLE--NHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQM--IVTLFPGQIRTF 2983
++ LF ++P GY +C KP++LNVH++ HTHDDVGWLKTVDQY+YG +NIQ AGVQYIL++VIS+L NP R+F YVEIA+F RWW+QQ + + V+ LV +GRL+F GGW MNDEATTHY +IIDQM+LGL FL +TFG GRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK+ R T ME + + S LFT+VL + Y P G C+D C+D P+++D +YN ++ V F Q K Y+T H ++ MG DFQ++NAN F NLDKLI VN ++ +NV YSTPACY +NK +K DDFFPYA GP +WTGYF+SR ALK + + S N QVC QL L+ + LN+ M V QHHDAVSGT +QHVA DYA++LS+G CE +++++L+ L + DF C LNIS C ++ + V++YNPLG +++W R+PV+ Y + G +VPS +V I + EL F +++PA+G++ ++ + S+D +VI N+YL+ +D G L+ L NL+ N+ + + Q +Y + GN Q SGAYIFRP N+ + ++ + ++K LV EVHQ FS W V RLY LE EWTVGPIP+ D GKE++ ++ T + + F+TDSNGR+I+ R+ N R + QTEPVAGNYYPVNS +++ + N + L + TDR+ G S ++G +E+MVHRR L DD GVGEPLN+ +G+GL VRG+ + D + ++ RL++ P VV ++ + Q+S L LP V +L+L L +++Q E+ + L+ +F + IT + E L+ANQ L RL+W + + S + +TL P +IRTF
Sbjct: 35 LSSLFVLFLAAPCAWAAGYKTCPKVKPDMLNVHLVPHTHDDVGWLKTVDQYFYGIYNNIQPAGVQYILDSVISSLLANPTRRFIYVEIAFFSRWWRQQTNATQKIVRELVRQGRLEFANGGWVMNDEATTHYGAIIDQMTLGLRFLEETFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRKKTLQMEQVWRASTSLKPPTADLFTSVLPNMYNPPEGLCWDMLCADKPVVEDTRSPEYNAKELVRYFLKLATDQGKLYRTKHTVMTMGSDFQYENANTWFKNLDKLIQLVNAQQRANGIRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNE-------AMAVLQHHDAVSGTSRQHVANDYARQLSEGWRPCEVLMSNALAHL---SGLKEDFAFCRKLNISICPLTQT---AERFQVIVYNPLG-RKVDWMVRLPVS---KHVYLVKDPGGKIVPSDVVTIPSSDSQ------------ELLFSALVPAVGFSIYSVSQMPNQRPQKSW-------SRD-LVIQNEYLRARFDPNTGLLMELENLEQNLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQ-----LTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNK---EGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQGGGARYRLEKAPRTQFSGLRRELPPSVRLLTLARWGPETLLLRLEHQFAVGEDSGRNLSSPVTLDLTNLFSAFTITNLRETTLAANQLLAYASRLQWTTDTGPTPHPSPSRPVSATITLQPMEIRTF 989
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|Q60HE9|MA2B1_MACFA (Lysosomal alpha-mannosidase OS=Macaca fascicularis OX=9541 GN=MAN2B1 PE=2 SV=1) HSP 1 Score: 708.753 bits (1828), Expect = 0.000e+0 Identity = 400/985 (40.61%), Postives = 571/985 (57.97%), Query Frame = 2
Query: 125 GYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL----------SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLV--PITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS-KDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK------NTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
GY +C +PN+LNVH++ HTHDDVGWLKTVDQY+YG +++IQ AGVQYIL++VISAL +P R+F YVEIA+F RWW QQ + +R V+ LV +GRL+F GGW MNDEA THY +I+DQM+LGL FL TFG GRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK R+ ME + + S LFT VL + Y P C+D C D P+++DP +YN ++ VD F + Q + Y+TNH+++ MG DFQ++NAN F NLDKLI VN + ++V YSTPACY +NK +K+DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + LNK M V QHHDAVSGT +QHVA DYA++L+ G CE +++++L++L C LNIS C +S + V++YNPLG ++ W R+PV+ + + NG VPS +V P ++ H P EL F + LPALG+++ ++ + + ++ S + I N++++ T+ D G L+ + N+ + + + Q +Y + G+ Q SGAYIFRP + +P+++ ++ ++K LV EVHQ FS W V RLY LE EW+VGPIP+ D+ GKE++ ++ T +++ F+TDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + K L + TDR+ G S ++G +E+MVHRR L DD GV EPL E +G+G VRG+ + D + RL + + P VV + N Q+S L LP V++L+L + L +++Q E+ + LN + +F + IT + E L ANQ + RLKW N+ +Q + + +TL P +IRTF
Sbjct: 52 GYETCPTVQPNILNVHLVPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNAMREVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKRVRMQKLEMEQVWRASASLKPPTADLFTGVLPNGYNPPMNLCWDVLCVDQPVVEDPRSPEYNAKELVDYFLNVATAQGRHYRTNHIVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNK-------AMAVLQHHDAVSGTSRQHVADDYARQLAAGWVSCEVLLSNALARL---RGFKDHLTFCRQLNISICPLSQTAAR---FQVIVYNPLG-RKVNWMVRLPVS---EGVFVVKDPNGRTVPSDVVIYPSSDSQAHPP----------ELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQRLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIRLVKTPLVQEVHQNFSAWCSQVVRLYPGRRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYIT-----DGKMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDERGVSEPLME---NGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRELPPSVHLLTLASWGPEMLLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTF 1001
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|Q8VHC8|MA2B1_CAVPO (Lysosomal alpha-mannosidase OS=Cavia porcellus OX=10141 GN=MAN2B1 PE=1 SV=1) HSP 1 Score: 704.131 bits (1816), Expect = 0.000e+0 Identity = 409/990 (41.31%), Postives = 564/990 (56.97%), Query Frame = 2
Query: 119 TCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHV----------LSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLI-SKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLG--VTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXIN-SKDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNIS---------KFDQYSALLDNLPSGVNILSLENHF--NLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTS--NQMIVTLFPGQIRTF 2983
GY +C +P +LNVH+++HTHDDVGWLKTVDQYY+G +++Q AGVQYIL++VISAL P R+F YVE+A+F RWW QQ + + V+ LV +GRL+F GGW MNDEA THY +I+DQM+LGL FL TFG GRP V+W IDPFGHS EQA++FA MGFDG+FF R+DY+DK R + ME + + S LFT VL ++Y P G C+D C+D P++DDP +YN +K V F Q + Y+TNH ++ MG DFQ++NAN F NLDKLI VN + + ++V YSTPACY +NK +K DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL + + LN+ M V QHHDAVSGT KQHVA DYA++L+ G CE +++++L+KL SKET F+ C LNIS C S ++ VL+YNPLG V RM R+PV + I + VPS +V +T S N EL F +++PALG++ ++ R N T+S + S + I N+YL+ ++ D G L + L +++ + Q +Y + G+ Q SGAYIFRP+ P++ + ++K LV EVHQ F+ W V RLY+ LE EWTVGPIP+ D GKEI+ ++ T +++ FFTDSNGR+++ R+ + R + QTEPVAGNYYPVNS +++ + K L + TDR+ G S +G +E+MVHRR L DD GVGE L E G+ G VRG+ + D ++ RL + K P +V + S Q+S L LP V +L+L L +++Q E+ + L+ Q +F + IT + E L+ANQ RLKW + D + +TL P +IRTF
Sbjct: 47 AAGYETCPMVQPGMLNVHLVAHTHDDVGWLKTVDQYYWGIHNDLQQAGVQYILDSVISALLAEPTRRFVYVEMAFFSRWWHQQTNETQEVVRRLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGVFFGRIDYQDKLVRKKRREMELVWRASASLKAPAADLFTGVLPNNYGPPEGLCWDVLCADPPVVDDPRSPEYNAKKLVSYFLQLATAQGRYYRTNHTVMTMGSDFQYENANTWFKNLDKLIQLVNMQQANGSRVHVLYSTPACYLWELNKANLTWPVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEAQVGPAANVGPYGHGDSSPLNQ-------AMAVLQHHDAVSGTSKQHVADDYARQLAAGWGPCEVLLSNALAKLSGSKET----FLFCRDLNISICPFSQT---SERFQVLVYNPLGRKVDRMV--RLPVR---KGLFLIKDPGNNTVPSTVVELT------------SSGNPELLFPALVPALGFSVYSVTRVSDQNPQTRSQHSRPQKYSSPVLSIKNEYLRASFHPDTGLLSMIEVLDRKLTLPVNQAFFWYNASVGDKRSSQASGAYIFRPSQQWPFPVSHLARTRLVKTALVQEVHQNFTAWCSQVVRLYSGQRHLELEWTVGPIPVGDKWGKEIISRFDTPLETGGVFFTDSNGREVLERRRDYRPSWKLNQTEPVAGNYYPVNSRIYIT-----DGKMQLTVLTDRSQGGSSMSDGSLELMVHRRLLKDDGRGVGEALQEPGSGG---WVRGRHLLLLDTAREAAAEHRLLAEKELLAPQLVLAPGQGPSYHHDHHEAVPRKQFSGLRRQLPPSVRLLTLARWGPDTLLLRLEHQFALGEDSSRNLSLPVTLDLQDLFSTFTITRLQETTLAANQLRASASRLKWTTEIDPISRPAVPRLDPSSITLQPMEIRTF 997
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|O00754|MA2B1_HUMAN (Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3) HSP 1 Score: 701.434 bits (1809), Expect = 0.000e+0 Identity = 398/985 (40.41%), Postives = 572/985 (58.07%), Query Frame = 2
Query: 125 GYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL----------SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLV--PITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS-KDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK------NTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
GY +C +PN+LNVH++ HTHDDVGWLKTVDQY+YG +++IQ AGVQYIL++VISAL +P R+F YVEIA+F RWW QQ + + V+ LV +GRL+F GGW MNDEA THY +I+DQM+LGL FL TFG GRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK R+ ME + + S LFT VL + Y P C+D C D P+++DP +YN ++ VD F + Q + Y+TNH ++ MG DFQ++NAN F NLDKLI VN + ++V YSTPACY +NK +K+DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + LN+ M V QHHDAVSGT +QHVA DYA++L+ G CE +++++L++L F C LNIS C +S + V++YNPLG ++ W R+PV+ + + NG VPS +V P ++ H P EL F + LPALG+++ ++ + + ++ S + I N++++ T+ D G L+ + N+ + + + Q +Y + G+ Q SGAYIFRP + +P+++ ++ ++K LV EVHQ FS W V RLY LE EW+VGPIP+ D+ GKE++ ++ T +++ F+TDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + N + L + TDR+ G S ++G +E+MVHRR L DD GV EPL E +G+G VRG+ + D + RL + + P VV + N Q+S L +LP V++L+L + + +++Q E+ + LN + +F + IT + E L ANQ + RLKW N+ +Q + + +TL P +IRTF
Sbjct: 51 GYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNE-------AMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARL---RGFKDHFTFCQQLNISICPLSQTAAR---FQVIVYNPLG-RKVNWMVRLPVS---EGVFVVKDPNGRTVPSDVVIFPSSDSQAHPP----------ELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQ-----LTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLME---NGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTF 1000
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|O09159|MA2B1_MOUSE (Lysosomal alpha-mannosidase OS=Mus musculus OX=10090 GN=Man2b1 PE=1 SV=4) HSP 1 Score: 679.093 bits (1751), Expect = 0.000e+0 Identity = 400/999 (40.04%), Postives = 577/999 (57.76%), Query Frame = 2
Query: 74 LIINILFFGIYSSP--TTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL--SQQNRTDLNK-KIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPV---NVLHGDEY-KISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK--IVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFS------KNTNISKFDQYSALLDNLPSGVNILSLENHFN--LNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKW--NSTNDNYQNFFTSNQMIVTLFPGQIRTF 2983
L I+ LF+ + ++P GY +C P KP +LNVH++ HTHDDVGWLKTVDQYYYG ++Q A VQYIL++V+S+L E P R+F YVE+A+F RWW+QQ S ++ V+ LV +GRL+F+ GGW MNDEA THY +I+DQM+LGL FL TFG G P V+W IDPFGHS EQA++FA MGFDG F R+DY+DK R ME + + S LFT VL ++Y P C+D C+D P++D+P ++N + V+ F Q Y+TNH ++ MG DF ++NAN F N+DKLI VN + + ++V YSTP CY +NK +K DDFFPYA GP+ +WTGYF+SR ALK + + S N QVC QL L + N + M V QHHDAVSGT +Q+V DYA++L+ G CE +++++L++L S N+ F C LNIS C +S ++ V +YNPLG + R+PV N + D + K SN +VPS +EL F + +PALG+++ ++ + N + + K +VI NKY++ T+D+ G L+ + NL+ N+S+ ++Q +Y + G+ Q SGAYIFRP + +P+++ +++++K LV EVHQ FS W V RLY LE EWTVGPIP+ D GKE++ ++ T + + FFTDSNGR+I+ R+ + R + QTEPVAGNYYPVN+ +++ + + L + TDR+ G S ++G +E+MVHRR L DD+ GV EPL ET G VRG+ + + + ++ RL + + P VV S ++ + Q+S L LP V++L+L L +++Q E+ + LN Q +F++ I + E L+ANQ L RLKW N+ +Y + VTL P +IRTF
Sbjct: 32 LPISFLFWLLLAAPGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARL-SHYKQNFSF--CRELNISICPVSQT---SERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYY---------------SETYQWELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYIT-----DGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLET---DTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTF 1001
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A210QAB9 (Alpha-mannosidase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT05957 PE=3 SV=1) HSP 1 Score: 827.395 bits (2136), Expect = 0.000e+0 Identity = 462/1023 (45.16%), Postives = 642/1023 (62.76%), Query Frame = 2
Query: 50 MAFILVVSL--IINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR--KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNK-KIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKL----ISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDK----IVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG-----QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVF----SKNTNISKF--DQYSALLDNLPSGVNILSLENHFN---LNNEIDYQIIRVENVFYQFGHS-----IKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFT-----SNQMIVTLFPGQIRTFKIVSKS 3001
MA + V L I+ + F S TCGY SCN K ++NVH++ HTHDDVGWLKTVDQY+YG + +IQ AGVQYIL+ VI L ++PN++F YVE+A+F RWW+QQ ++R+ VK LVN+G+L+F+LGGWCMNDEA+THY +IIDQ +LG +FL FG+CGRP V+WQIDPFGHS EQA++FA MGFDGLFF RLDY+DK R +K ME + KGS K + LFT L+ Y P GFCFD CSDDPIMDD + DYNV ++V+ F + + + AY T H+L+PMG DF +Q+AN F NLDKLI HVN+ +NV YSTP+CY ++NK G + K DDFFPYA +S+WTGYF+SR ALK +V+ +NN QVCKQ+ ++ TD + +I + MGVAQHHDAVSGTEKQ VA+DYAQRL+ G+++C+ V+N + KL S F CN LNIS C +++N K T+ +YNPLG W RIPV G Y++ + S VPSQ++P+T TK +PER + S+A EL F++ +PALG++ I +S K+ +T K K+K V+ N+++ LT+D NG L + NL S++ + + Q Y + GN Q SGAY+FRP + ++ + K + +G +V EVHQ FS W V RLY E EWTVGPIPI D GKE+ + + +D+ F+TD+NGR+I+ RQ N+R + QTEP+AGN+YPVNS ++ + ++ L + TDR+ G S +G I++MVHRR L+DD GVGEPLNETG D GL+VRGK ++ + + R +L+++ P + F K TN +K+ Q+S + LP+ V++L+LE + + IIR+E++F HS +N Q +F + + V EL L AN L D+ RL+WN+T+ N + ++ ++V L P QIRT+++ KS
Sbjct: 1 MARLSVYPLFGILVVFFLQAVDSAATCGYESCNAVKEGMINVHLVPHTHDDVGWLKTVDQYFYGDKSDIQRAGVQYILDAVIPELIKDPNKRFIYVEMAFFARWWRQQGDSMRHTVKRLVNQGQLEFILGGWCMNDEASTHYNAIIDQHTLGFEFLRHNFGDCGRPRVAWQIDPFGHSREQASLFAQMGFDGLFFGRLDYQDKFVRAISKTMEMVWKGSPSNLKKTSDLFTGALFRGYGPPKGFCFDLLCSDDPIMDDDRMQDYNVPQKVEMFVNASKEWALAYATKHVLMPMGSDFNYQSANAWFKNLDKLIKHVNKQSNTSKVNVLYSTPSCYLSSLNKAGIRWPTKEDDFFPYAHRAHSFWTGYFSSRPALKEYVRRTNNFLQVCKQMDAIAMLRDTDNSTYEIQILKEAMGVAQHHDAVSGTEKQPVAYDYAQRLARGVAECQKVVNDAFGKLSPFNTSVSPPGQQF--CNSLNISVCGLTENY---KQFTLTVYNPLGQAVTSWVRIPVV---GKAYEVKGHDDSSVPSQVIPLTKDTKRIPER-QGSIAQNELVFKTSVPALGFSVYFIKKSNKARVKFAQTTSKKRLIKNKEGTDTVLKNEHVSLTFDGTNGRLKRMRNLNSDIEIGLQQGFYCYQGHTGNNTEDIFQASGAYVFRPNSTKAFKSKQFEKSYVREGRVVQEVHQTFSPWVTQVIRLYEGEMHAEFEWTVGPIPIADGVGKEVASAFLSTLDTKGSFYTDANGREILKRQRNERATWLLKQTEPIAGNFYPVNSRIY---VKDEALGIQLTVLTDRSQGGSSIIDGGIQLMVHRRLLYDDGLGVGEPLNETGLDHKGLVVRGKHYVFLGGFEESAAFHRKMALRLYMAPSLSFIPYVMKYTNWTKYFQTQWSGINYTLPANVHLLTLEQWGGPGAVPSSSQPYIIRLEHIFENGEHSQLSKDATVNLQGLFVTFTVDSVTELTLGANMALSDLHRLQWNTTDVNMNDAPVLPTDQTDSLVVKLTPMQIRTYQVQIKS 1011
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A1S3IXF1 (Alpha-mannosidase OS=Lingula unguis OX=7574 GN=LOC106168249 PE=3 SV=1) HSP 1 Score: 821.231 bits (2120), Expect = 0.000e+0 Identity = 448/994 (45.07%), Postives = 623/994 (62.68%), Query Frame = 2
Query: 119 TCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLY-DSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNK-KIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFV--LCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINS-KDKIVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQK-----SGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK-----NTNISKFD-QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKL------NFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVT---------LFPGQIRTFKIV 2992
TCGY SCN GK ++NVH++ HTHDDVGWLKTVDQY+YG + IQ AGVQYIL++V+ AL ++PN++F YVEIA+FYRWW +QD R+ VK LVN+GRL+F+LGGWCMNDEA+THY +IIDQ + G FL FG+CGRP V+WQIDPFGHS E A++FA MGFDGL+F RLDY+D+ R K ME + +GS LFT L +Y P GFC+D C+D+P+ DD LHDYNV V F +Q+K YQTNHL+ MG DFQF++A+ + NLDKLI +VN + + +N YSTP+CYT A N K DDFFPYA + +WTGYFTSR+ALKG+V+++NN Q KQL +LS+ + D ++ K+ ++ MGVAQHHDAVSGTEKQHVA+DYA RLS+G+S C+ V+N + KL+ K V C L NIS C +++ + K TV +YNP+G W R+PV G Y + +G VP+Q+VP++ TK +PER +S ANYEL F P LG+A+ + + F + T + N + + N+++ L +D G L ++NL +++ + + +YY S+ GN K SGAYIFRP ++ PL ++G LV EVHQ FS W +VTRLY + +E EWTVGPIPI+D++GKE++ + TD+ ++ F+TDSNGR+I+ R+ N R + QTEPV+GNYYP+NS ++ + ++ + L + DR+ G S ++G +EIMVHRR L DD+ GVGEPLNETG+DG GLIVRGK ++ D I + R + ++F P+ FS I +++ +S L LP V++L+LE ++R+E+ FY+ G L + + +F ++ +ELNL ANQ L D+KRLKW Y+ ++ + +VT L P QIRTF++
Sbjct: 62 TCGYKSCNLGKDGMINVHLVPHTHDDVGWLKTVDQYFYGANNTIQHAGVQYILDSVVEALGKDPNKRFIYVEIAFFYRWWNEQDDPTRHFVKGLVNQGRLEFILGGWCMNDEASTHYNAIIDQHTEGFRFLETVFGDCGRPRVAWQIDPFGHSREMASLFAQMGFDGLYFARLDYQDRAVREKDKRMEMVWRGSPQNLGTVADLFTGALARGNYGPPGGFCWDVHCNDNPVQDDKRLHDYNVDDLVKKFLATTQEQAKQYQTNHLMWTMGSDFQFESAHQWYKNLDKLITYVNAQQANGSKVNALYSTPSCYTYAKNLANVTWTTKEDDFFPYAHVDHGFWTGYFTSRAALKGYVRWTNNFLQGVKQLDILSKLDTMDNSEIKLRTLRQAMGVAQHHDAVSGTEKQHVAYDYAMRLSEGISMCQEVVNDAYKKLLPKNNSATPPVQMFCTLTNISMCNVTELL---KRFTVTVYNPIGRPVTTWLRLPV---QGSAYTVIGPDGKNVPAQIVPVSKRTKSIPER--KSPANYELVFHVSPPPLGFATYFVSYNSALEVFKQQQTQEKENVFYQDMDLRNEHISLIFDQTTGLLKQMTNLDKQITIPLQHEFKYYQSFAGNNSKGIYEASGAYIFRPNGTDAYPLKTNMVTKFMQGILVKEVHQTFSSWTTLVTRLYQGARHVEMEWTVGPIPIDDNQGKEVISHFATDLKTNGIFYTDSNGREILQRKRNFRPTWKLNQTEPVSGNYYPINSRIY---IRDETKNVQLTVLNDRSQGGSSIQDGCLEIMVHRRNLHDDSLGVGEPLNETGSDGKGLIVRGKHYLVLDDIKSSGRVHRDLAEQLFMAPLPSFSDLKMDFQQWIKQYNTMWSGLKQKLPDNVHLLTLEQWSGTT-----VLLRLEH-FYEKGEDDVLSKPAVVSLKGLFTPFDVSSAVELNLGANQKLADMKRLKW-----MYKTQLSTPEHVVTPIGDDLTVQLQPMQIRTFQVT 1033
BLAST of Alpha-mannosidase vs. TrEMBL
Match: R7T6U8 (Alpha-mannosidase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_151096 PE=3 SV=1) HSP 1 Score: 801.586 bits (2069), Expect = 0.000e+0 Identity = 437/1000 (43.70%), Postives = 627/1000 (62.70%), Query Frame = 2
Query: 98 GIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD----INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFV--LCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKE-SLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGNG-----QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNT------NISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHS------IKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWN-----STNDNYQNFFT-----SNQMIVTLFPGQIRTFKI 2989
I +CGY +C+ G P+++NVH++ HTHDDVGWLKTVDQY+YG ++NIQ AGVQYIL++V+ AL +P +F YVEIA+F RWW++ + R+ VK LVNEGRL+F+LGGWCMNDEA+THY +IIDQ +LG DFL +TFGEC RP + WQIDPFGHS EQA++FA GFDGLFF RLDY+DK++R+ K ME + S LFT V Y+ Y P GFCFD C+D+PIMDD L DYNV RV DF V Q+K Y TNH+++ MG DFQF+NA+ NF NLDKLI +VN ++ IN+ YSTP+CY A+NK + +K DDFFPYA+ +S+WTGYFTSR ALKG+V+ +NN+ QVCKQL++L++ ++ + + MGVAQHHDAVSGTEKQ VAFDYA+RL+ G++ C+ VI + +L+ + + V C L N+S C+ ++++ TV+ YNP+G + R+PVN G + +S + G+ +PSQ+V +T T+ +PE K S + +L FQ LPALG+A+ + + K + T + + I N++ LT+D G L S++N++ ++++ +TQ + +Y ++GN + SGAY+FR +E+ ++ + +KG +V E+ Q F W V RLY +E E+T+GPIPI+D GKE++ ++ ++I S+ F+TDSNGR+++ R + R +N QTEPVAGNYYPVNS +++ + K L I TDR+ G S +G IE+M+HRR L DD FG GE LNETG G GL+VRGK + D + + + R + ++F P V +++N+ N ++A++ LP V++L+LE E ++R+E+ FY+ G LN +F+ + + V E L A++ L +V+RL+WN TN +F T V L P QIRTF I
Sbjct: 77 AIEDESGSCGYQACDLGHPDLVNVHLVPHTHDDVGWLKTVDQYFYGSKNNIQHAGVQYILDSVLEALLSDPKHRFIYVEIAFFARWWRELHDSSRHVVKKLVNEGRLEFILGGWCMNDEASTHYNAIIDQHTLGFDFLRETFGECARPKIGWQIDPFGHSREQASLFAQFGFDGLFFGRLDYQDKDKRLNDKTMEMMWAASDSLGVNQAGLFTGVNYNGYGPPDGFCFDRGCADEPIMDDDRLEDYNVLPRVVDFIKAVHDQTKHYTTNHIMMTMGSDFQFENAHQNFKNLDKLIKYVNDQQRQSDSKINLIYSTPSCYLYALNKANQTYSVKKDDFFPYANEAHSFWTGYFTSRPALKGYVRNTNNLLQVCKQLNILAR--KSSFVQPDQRLLEAMGVAQHHDAVSGTEKQAVAFDYAKRLARGVAACQIVIQEAYDQLLPINSGDKAPVQEFCPLANVSSCSALEDVNS---FTVVAYNPVGRSGNYNFRVPVN---GSAFIVSDAAGNTIPSQVVNVTAATEAIPEYQKNTSTISADLVFQGKLPALGFATFFVQKKKGKEAPTPQAKWTAPTT--DFSIQNEFTSLTFDGATGLLKSMTNMEKSLTIPLTQTILFYKGFKGNNSEPQFRASGAYVFRSNGSEAELISDKATINFVKGGVVQEIQQSFGGWASQVIRLYAGKREVEIEFTIGPIPIDDGIGKEVISRFTSNIASEGVFYTDSNGREMLKRVRDYRPTWNLNQTEPVAGNYYPVNSRIYIKD--EKSSNVQLTILTDRSQGGSSLVDGEIELMLHRRLLVDDAFGAGEALNETGVGGQGLVVRGKHVLILDSVVDSPRRHRDLAERLFMSPQVTYAENSLAPNDYNKKYKTMWTAMVSELPDNVHLLTLEQR-----EGTQYLLRLEH-FYEEGEDEQLSKPATLNIADLFKGMTVLSVDEYALGADRLLAEVQRLEWNIEGVGRTNGRMVDFVTPVLEGPGLFQVELKPMQIRTFVI 1058
BLAST of Alpha-mannosidase vs. TrEMBL
Match: V9KD73 (Alpha-mannosidase (Fragment) OS=Callorhinchus milii OX=7868 PE=2 SV=1) HSP 1 Score: 795.808 bits (2054), Expect = 0.000e+0 Identity = 438/1011 (43.32%), Postives = 626/1011 (61.92%), Query Frame = 2
Query: 62 LVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF-LPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTD---LNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNIS-------KFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQ--IIRVENVFYQFGHS------IKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDN---YQNFFTSNQMI--VTLFPGQIRTFKIVSK 2998
L + L ++ + S TCGY SC +P +LNVH++ HTHDDVGWLKTVDQY+YG R+ +Q AGVQYIL++VIS L +P+++F YVE A+ YRWW+QQ+ + V+ LV++GRL+F+ GGWCMNDE +THY ++IDQMSLG FLN+TFGECGRP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DK R ++ME + + S LP + + LFT VL + Y P GFC+D C+D+PI DD L +YNV V+ F +Q+K+Y+TNH+++ MG DFQF+NA+ + N+DKLI +VN + DINVFYSTP+CY + +NK +K DDFFPYA GP+ +WTGYFTSR A K + + SNN Q+C QL VL+ + ++ + VAQHHDAVSGTEKQ+V +DYA+RL+ G C+ ++ ++LS L + +F CN LNIS C ++++S TV +YNPLG R+PVN G Y +S + G VP+Q+V ++ T+ + R A EL F++ +PA+G+ + T+ R + S S S I NK++++ +D G + + NL+ N+S+ +T + +Y +G+ GQ SGAYIFRP + P+ + ++ + E+HQ FS W V RL+ + ++E EWTVGPIP+ DS+GKEI+ ++ T + +D F+TDSNGR+I+ R+ + R ++F QTEPVAGNYYPVN+ +F+ ++ K L + TDR+ G S ++G +E+MVHRR +FDD GVGE LNE G DG GL+VRGK + D RL + + + P+VV + T + + ++SAL LPS V++L+L + D Q IIR+E+ F Q G S + ++ Q + +ITEV E+ L ANQ L+D+ RL W S D + + M+ VTL P +IRTF+ K
Sbjct: 1 LCLRLCLSGCLLALGSRAATCGYQSCPVTRPGMLNVHLVPHTHDDVGWLKTVDQYFYGARNAVQHAGVQYILDSVISQLRSDPSKRFIYVETAFLYRWWKQQNPETQEVVRELVSQGRLEFINGGWCMNDEGSTHYNAMIDQMSLGFQFLNETFGECGRPRVAWHIDPFGHSREQASLFAQMGFDGYFFGRLDYQDKYVREKQRDMEQVWRASADLPKPLAD-LFTGVLPNGYNPPRGFCWDMTCTDEPIKDDKDLEEYNVDTIVEYFISTARQQAKSYRTNHIIMTMGSDFQFENAHMWYSNMDKLIKYVNTKQTSGSDINVFYSTPSCYLMELNKANLTWSVKFDDFFPYADGPHEFWTGYFTSRPAFKLYERLSNNFLQICNQLEVLTGSDAHSGPYGAGDSATLKRAVAVAQHHDAVSGTEKQNVVYDYAKRLAGGWDKCQVLVANALSILTGTKQ---NFAFCNNLNISVCPQTESLS---AFTVTVYNPLGRPVSSVVRLPVN---GSVYSVSDARGQTVPNQVVAVSAVTRRV--RNGRGYAVNELVFEASVPAVGFTTFTVSRQQPSTGAPGPSDQTP--SDQTPSIQNKHIRVRFDPVTGLISGIDNLEKNLSLPVTHNFYWYTGSKGDYRSGQTSGAYIFRPVEGKPYPMAANASIYKVQTAMFEEIHQNFSSWCSQVVRLHRNQRMVELEWTVGPIPLADSRGKEIISRFDTPLKTDGLFYTDSNGREILQRRRDYRPTWHFNQTEPVAGNYYPVNTRIFI-----RDGKFQLSVLTDRSQGGSSIEDGSLELMVHRRLIFDDGRGVGEALNEPGEDGKGLVVRGKHLLFLDTPSASGQLHRLAAEQQYMAPLVVVAGGTGAAYRTSSRMQTTEFSALRTELPSSVHLLTLA-------QWDPQTVIIRLEHQF-QRGESEELSKPVSVDLQNLLSGFEITEVEEMTLGANQRLRDMSRLTWRSGRDPSPLSREPGKPSGMLRSVTLNPMEIRTFRAQVK 984
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A498NPX4 (Alpha-mannosidase OS=Labeo rohita OX=84645 GN=ROHU_015147 PE=3 SV=1) HSP 1 Score: 795.808 bits (2054), Expect = 0.000e+0 Identity = 442/999 (44.24%), Postives = 613/999 (61.36%), Query Frame = 2
Query: 62 LVVSLIINILFFGIYSSPT----TCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTD---LNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDN--GFXXXXXXXXXXXXXXITQDMRYYFSYQGN---GQKSGAYIFRPTTNESMPLTKAPKLTIIK-GDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFD-QYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMI---VTLFPGQIRTF 2983
L +S + + F ++S PT CGY SC P++LNVH++ HTHDDVGWLKTVDQY+YG R+NIQ AGVQYIL++VI L ++P R+F YVE A+FYRWW+QQ + + V LVNEGRL+F+ GGWCM+DEATTHY ++IDQM+LGL FLN TFGECGRP V+W IDPFGH+ E A+IFA MG+DG FF RLDY+DK +R+ TK ME + + S T LFT VL + Y P GFC+D C D PI DDP L DYNV + V F + KQ+ Y+TNH+++ MG DFQ++NAN + N+DKLI +VN L+ +NV YSTP+CY +N +K DDFFPYA + +WTGYFTSR ALK + + SN+ Q C QL VL T +M MGVAQHHDAVSGTEKQHVA+DYA+RL+ G + CE ++ +SL+ L E V C LNIS C ++++ + ++ +YNPLG T R+PVN G Y ++ S G V SQ+VP++ TK + R A EL FQ P LGY++ II K S+ S I NK+LK+T+D+ G L SL+NL++N ++ +TQ+ +Y + GN Q SGAYIFRP +++ + + K ++ I+ + V EV Q FS W V RLY LE EWTVGP+P+ D GKE++ + +TDI S +CF+TDSNGR+++ R+ + R ++ QTEPVAGNYYP+NS ++ ++K + L + TDR+ G S NG +EIM+HRR L DD GVGEPL+E G +GL+VRG + D R + + +P++ F T + Q+S L +LP V++L+L + D ++R+E+ + + + +N QK+F ++K+ E++L ANQ+ +D+ RL+WN + ++ VTL P +IRTF
Sbjct: 4 LCISFLFQLFFCLVFSLPTGRNSICGYKSCPATNPSMLNVHLVPHTHDDVGWLKTVDQYFYGDRNNIQHAGVQYILDSVIDQLQKDPARRFIYVETAFFYRWWKQQSQSTQRIVTQLVNEGRLEFINGGWCMSDEATTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDKARRMKTKEMEMLWRASESLTPPVADLFTGVLPNGYNPPEGFCWDQSCDDAPIRDDPDLEDYNVDEIVQLFVNTSYKQAAFYKTNHIIMTMGSDFQYENANLWYKNMDKLIKYVNALQAKGSKVNVLYSTPSCYLQELNLANFTWPLKTDDFFPYADAAHDFWTGYFTSRPALKLYERLSNSRLQTCNQLEVLGGSKSTSGPFGEGDSDTMKRAMGVAQHHDAVSGTEKQHVAYDYARRLATGWAHCEILVRNSLAVLSGSEAPR---VFCENLNISVCPLTES---SHKFSMNVYNPLGRTVSWPVRLPVN---GSAYNVTDSTGKTVESQVVPLSKSTKEV--RRNRGYAKGELVFQVEAPPLGYSTY-IISMHKDEPQASSAKPTATRS-----IQNKFLKVTFDDTTGLLSSLTNLETNQTIRLTQNFYWYNASVGNTESPQTSGAYIFRPNSSDPLVINKTAEIQIVTLSNTVQEVTQWFSPWVSQVVRLYEGRKELELEWTVGPVPVADGLGKEVITRLETDIKSSDCFYTDSNGREVLERRKDYRPTWDLKQTEPVAGNYYPINSRAYIKASDDKHQ---LTVVTDRSQGASSLYNGSLEIMLHRRLLHDDFRGVGEPLSEPGEFSDGLVVRGHLLLTLTPPDTAADVHRPLAQGMVLQPLLSFQDGTPSANTKLQFSGLQADLPPAVHLLTLSQW-----DKDLVLVRLEHQYEAKESKTYSQPVTVNLQKLFSTLKVLGASEMSLGANQWKEDMNRLQWNPEKTSKPLPLSAKDPSPGEVTLNPMEIRTF 977
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 716.842 bits (1849), Expect = 0.000e+0 Identity = 406/970 (41.86%), Postives = 583/970 (60.10%), Query Frame = 2
Query: 131 NSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-SQQNRTDLNKKIISMAMK--MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMI--VTLFPGQIRTF 2983
+SC KP++LNVH++ HTHDDVGWLKTVDQYYYG R+ IQ AGVQYIL++V+S L ++P R+F YVE A+F+RWW +Q + RN V LV EGRL+F+ GGWCM+DEA+THY ++IDQM+LGL + A+IFA MG+DG FF RLDY+DK +R+ K ME + + S LFT VL + Y P GFC+D CSDDP+ DDP L DYNV V+ F Q+ Y+TNH+++ MG DFQ++NA + N+DKLI +VN +K+ +NV YSTP+CY +N + IK DDFFPYA + +WTGYFTSR ALK + + SN++ Q C QL VL Q+R K S M+ M VAQHHDAVSGTEKQHVA DYA+RL G C+ ++++SL+ L N V C LNIS C +++ +K ++ +YNPL + W +PVN G Y + SNG V SQ++P++ T++L R A EL FQ P LG+++ +II ++ + + ++ + NKYLK T+D G L L+NL++ S+ ++Q+ +Y + GN Q SGAYIFRP ++ ++ P ++ ++ +V EV Q FS W V RLY S LE EWT+GP+P++D GKE++ + + I S F+TDSNGR+++ R+ + R ++ QTEPVAGNYYP+NS F+ K++ L + TDR+ GV S NG +EIM+HRR L+DD GVGEPL+E G G+GL+VRG+ + + R + + +P++ F T S ++SAL +LP V++L+L + D ++R+E+ + + + +N QKMF ++K+ E++L ANQ+ ++ RL+WN+ ND + + SN +TL P +IRTF
Sbjct: 10 DSCPATKPSMLNVHLVPHTHDDVGWLKTVDQYYYGGRNYIQHAGVQYILDSVVSELQKDPARRFIYVETAFFHRWWSEQSAKTRNIVTQLVQEGRLEFVNGGWCMSDEASTHYSAVIDQMTLGL--------------------------QHASIFAQMGYDGFFFGRLDYQDKGRRMKMKEMEMVWRASESLKPPTADLFTGVLPNGYNPPAGFCWDQSCSDDPVQDDPELEDYNVDDLVNKFISISKAQADVYKTNHIIMTMGSDFQYENAIPWYKNMDKLIHYVNARQKNGSAVNVLYSTPSCYLQELNLAKQIWPIKTDDFFPYADDAHDFWTGYFTSRPALKRYERLSNSLLQTCNQLEVLGGSQSRDGPFGKGDSETMRRAMAVAQHHDAVSGTEKQHVANDYAKRLGIGWDHCQVLVSNSLAALSGS---NVPRVFCENLNISVCPLTEG---SKRFSMNVYNPLA-RPISWSVHLPVN---GSSYSVQDSNGMAVNSQVIPVSKATQNL--RRGRGYAKNELVFQVQAPPLGFSTYSIILLGRAGAPDEPKRAAPVS------MQNKYLKATFDPTTGLLSGLTNLETQQSIQLSQNFYWYNASNGNDESRQTSGAYIFRPNSSTPYTISSKPVVSTLQNSVVQEVRQQFSPWVSQVVRLYEGSRDLELEWTIGPVPVDDGLGKEVITRLDSSISSAEYFYTDSNGREVLQRRKDYRPTWDLKQTEPVAGNYYPMNSRAFI-----KDKGSQLTVVTDRSQGVSSLNNGSLEIMLHRRLLYDDYRGVGEPLSEPGEFGDGLVVRGRLLLTLTPPETAADAHRPLAQGMVLQPLLSFQDGTP-SAIVEFSALQASLPPAVHLLTLSQW-----DKDSVLLRLEHQYESSESKTYSKPVTVNLQKMFSTLKVVGASEMSLGANQWKANMTRLQWNTGNDAHI-YTCSNPTPWEITLNPMEIRTF 923
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 709.138 bits (1829), Expect = 0.000e+0 Identity = 405/975 (41.54%), Postives = 584/975 (59.90%), Query Frame = 2
Query: 128 YNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQAN-IFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD---INVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-SQQNRTDLNKKIISMAMK--MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWH-RIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQGNG---QKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTN-----DNYQNFFTSNQMIVTLFPGQIRTF 2983
+ SC KP++LNVH++ HTHDDVGWLKTVDQYYYG R+ IQ AGVQYIL++V+S L ++P R+F YVE A+F+RWW +Q + RN V LV EGRL+F+ GGWCM+DEA+THY ++IDQM+LGL L+ I P + +++ IFA+MG+DG FF RLDY+DK +R+ K ME + + S LFT VL + Y P GFC+D CSDDP+ DDP L DYNV V+ F Q+ Y+TNH+++ MG DFQ++NA + N+DKLI +VN +K+ +NV YSTP+CY +N + IK DDFFPYA + +WTGYFTSR ALK + + SN++ Q C QL VL Q+R K S M+ M VAQHHDAVSGTEKQHVA DYA+RL G C+ ++++SL+ L N V C LNIS C +++ +K ++ +YNPL + W +PVN G Y + SNG V SQ++P++ T++L R A EL FQ P LG+++ +II ++ + + ++ + NKYLK T+D G L L+NL++ S+ ++Q+ +Y + GN Q SGAYIFRP ++ ++ P ++ ++ +V EV Q FS W V RLY S LE EWT+GP+P++D GKE++ + + I S F+TDSNGR+++ R+ + R ++ QTEPVAGNYYP+NS F+ K++ L + TDR+ GV S NG +EIM+HRR L+DD GVGEPL+E G G+GL+VRG+ + + R + + +P++ F T +SAL +LP V++L+L + D ++R+E+ + + + +N QKMF ++K+ E++L ANQ+ ++ RL+WN+ Q T + +TL P +IRTF
Sbjct: 27 HTSCPATKPSMLNVHLVPHTHDDVGWLKTVDQYYYGGRNYIQHAGVQYILDSVVSELQKDPARRFIYVETAFFHRWWSEQSAKTRNIVTQLVQEGRLEFVNGGWCMSDEASTHYSAVIDQMTLGLPCLH--------------IRPGQKYLHRSDLIFANMGYDGFFFGRLDYQDKGRRMKMKEMEMVWRASESLKPPTADLFTGVLPNGYNPPAGFCWDQSCSDDPVQDDPELEDYNVDDLVNKFISISKAQADVYKTNHIIMTMGSDFQYENAIPWYKNMDKLIHYVNARQKNGSAVNVLYSTPSCYLQELNLAKQIWPIKTDDFFPYADDAHDFWTGYFTSRPALKRYERLSNSLLQTCNQLEVLGGSQSRDGPFGKGDSETMRRAMAVAQHHDAVSGTEKQHVANDYAKRLGIGWDHCQVLVSNSLAALSGS---NVPRVFCENLNISVCPLTEG---SKRFSMNVYNPLARP-ISWSVHLPVN---GSSYSVQDSNGMAVNSQVIPVSKATQNL--RRGRGYAKNELVFQVQAPPLGFSTYSIILLGRAGAPDEPKRAAPVS------MQNKYLKATFDPTTGLLSGLTNLETQQSIQLSQNFYWYNASNGNDESRQTSGAYIFRPNSSTPYTISSKPVVSTLQNSVVQEVRQQFSPWVSQVVRLYEGSRDLELEWTIGPVPVDDGLGKEVITRLDSSISSAEYFYTDSNGREVLQRRKDYRPTWDLKQTEPVAGNYYPMNSRAFI-----KDKGSQLTVVTDRSQGVSSLNNGSLEIMLHRRLLYDDYRGVGEPLSEPGEFGDGLVVRGRLLLTLTPPETAADAHRPLAQGMVLQPLLSFQDGT-----PSFSALQASLPPAVHLLTLSQW-----DKDSVLLRLEHQYESSESKTYSKPVTVNLQKMFSTLKVVGASEMSLGANQWKANMTRLQWNTGEILKPLQAEQGDPTPWE--ITLNPMEIRTF 952
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: ENSAMXT00000050868.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001371.1:2842:11113:-1 gene:ENSAMXG00000029432.1 transcript:ENSAMXT00000050868.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 264.618 bits (675), Expect = 4.755e-81 Identity = 117/189 (61.90%), Postives = 150/189 (79.37%), Query Frame = 2
Query: 134 SCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGS 700
SC KP++LNVH++ HTHDDVGWLKTVDQYYYG R+ IQ AGVQYIL++V+S L ++P R+F YVE A+F+RWW +Q + RN V LV EGRL+F+ GGWCM+DEA+THY ++IDQM+LGL FLN TFGECGRP V+W IDPFGH+ E A+IFA MG++ + F RLDY+DK +R+ K ME + + S
Sbjct: 30 SCPATKPSMLNVHLVPHTHDDVGWLKTVDQYYYGGRNYIQHAGVQYILDSVVSELQKDPARRFIYVETAFFHRWWSEQSAKTRNIVTQLVQEGRLEFVNGGWCMSDEASTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYEWVLFGRLDYQDKGRRMKMKEMEMVWRAS 218
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:103041860]) HSP 1 Score: 259.61 bits (662), Expect = 1.886e-71 Identity = 254/1024 (24.80%), Postives = 459/1024 (44.82%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLP---TKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNA---NHNFVNLDKLIFHVNRLRKDINV----------FYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSR-----------SALKGF-VQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCN--LLNISFCAISDNISYTKLLT-------VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYA---------------SLTIIRXXXXXXXXXXXXXXXINSK----DKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYY-FSYQGNGQKSGAYIFRPTTNESMPLTK--APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNI--LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGL-IVRGKQWIKFDYID----NIYSKMRLESLKIFNRPVV---VFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKI 2989
L V ++ H+H+D GW+KT D+YY N Q +Q+I N ++ L E+P RKF EI++F +WW D+ + ++ L+ G+L+ + GGW M DEA HY ++IDQ+ G +L + G P W +DPFGHS + + R+ Y K+ +T+++EF+ + ++ P T + ++ YD C P P C FD K ++ P + D NV +R + D K+SK +++ +L+P+G DF++ + + ++N KL ++N +++V F + ++ + + DFF YA + YW+GY+TSR S L+G + YS V H + + +++ A + +G+ QHHDA++GT K+ V DY RL L + VI ++ LI K Y F L A D++ L+ ++++NP+ R+ + VN + ++ +G +P QL + + S Y+ +F + LPALG A S T++R + + + S+ I + L L + + S + + + ++++ + + + KSGAY+F P N + P T+ P + +++G L EV + + V R++N + L + T + I D KE+ ++ TDI S++ F+TD NG QI R+ + Q P+ N+YP+ + ++ ++ + L +HT +A GV S +G +E+M+ RR + DDN G+G+ + + N ++ ++ +D + S + + I N V+ V K + ++ L + LP +L+L + N + + + ++ G L Q + T+ +L +SA D++ L+ S Y SN I++L P ++ T+K+
Sbjct: 166 LQVFVVPHSHNDPGWVKTFDKYY-----NDQ---MQHIFNNMVVKLAEDPRRKFILSEISFFVKWWDSADAHKQEAIRKLILGGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVI--PRSGWAVDPFGHSATMPYLLKKANVTSMLIQRIHYSIKKHFSSTRSLEFMWRQAWDPESGTDLFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAITDANVAERANVLLDQYRKKSKLFRSKVVLIPLGDDFRYDKSLEWDQQYINYQKLFDYMNS-HPEMHVQAQFGTLTDYFNAVYKANGVSQGARPPGYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYS---LAVSHARHAGMEGRYPTSDYSLLTDARRNIGLFQHHDAIAGTAKEAVVTDYGTRLLRSLIGLKRVIINAAHFLIMKNKDVYRFYQTEPFLETDDRRATQDSLPQRTLIELDSSPRYLVLFNPVEQERLCVVTVLVN---SAKVRVLTEDGQTLPVQLSAQWSSAVQM------SGEVYQASFMARLPALGLAVFHLYDSVDSPMTLRSDTLLRLPGRSQTVRGVDPLPVRSQIADPQPFYIQTQSLTLAFSGTTGLLESIRRKDDPQEVRVQVQFFTYGTRPSKDKSGAYLFLPDGN-AKPYTQRDPPIVRVVEGPLFAEVVTYYQHFQQTV-RIHNVPGVDGLSLDITTL-VDIRDQTNKELSMRLHTDIQSEDTFYTDLNGFQIQPRR--------YFQKLPLQANFYPMPTMAYI-----QDSQYRLTLHTAQALGVTSLASGQLEVMLDRRLMQDDNRGLGQGVKDNKRTANRFRLLLERRTSSSRAVDSGPVSFPSLLSHMTSSILNHEVLALPVIPKKRGVPPLRTFAPLANALPCDFRLLNLRS--IQNQDAQSPSLYTALLLHRLGLDCGLEAQNPGFNCTTTQG-KLAVSALFRGLDLQLLQPMSLTLMYSGTPLSNSSIISLEPMELSTYKL 1147
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:103041860]) HSP 1 Score: 254.988 bits (650), Expect = 9.235e-70 Identity = 223/858 (25.99%), Postives = 394/858 (45.92%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLP---TKIHNYLFTNVLYD--SYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNA---NHNFVNLDKLIFHVNRLRKDINV----------FYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSR-----------SALKGF-VQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCN--LLNISFCAISDNISYTKLLT-------VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYA---------------SLTIIRXXXXXXXXXXXXXXXINSK----DKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYY-FSYQGNGQKSGAYIFRPTTNESMPLTK--APKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNI--LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGN 2515
L V ++ H+H+D GW+KT D+YY N Q +Q+I N ++ L E+P RKF EI++F +WW D+ + ++ L+ G+L+ + GGW M DEA HY ++IDQ+ G +L + G P W +DPFGHS + + R+ Y K+ +T+++EF+ + ++ P T + ++ YD C P P C FD K ++ P + D NV +R + D K+SK +++ +L+P+G DF++ + + ++N KL ++N +++V F + ++ + + DFF YA + YW+GY+TSR S L+G + YS V H + + +++ A + +G+ QHHDA++GT K+ V DY RL L + VI ++ LI K Y F L A D++ L+ ++++NP+ R+ + VN + ++ +G +P QL + + S Y+ +F + LPALG A S T++R + + + S+ I + L L + + S + + + ++++ + + + KSGAY+F P N + P T+ P + +++G L EV + + V R++N + L + T + I D KE+ ++ TDI S++ F+TD NG QI R+ + Q P+ N+YP+ + ++ ++ + L +HT +A GV S +G +E+M+ RR + DDN G+G+ + + N
Sbjct: 166 LQVFVVPHSHNDPGWVKTFDKYY-----NDQ---MQHIFNNMVVKLAEDPRRKFILSEISFFVKWWDSADAHKQEAIRKLILGGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVI--PRSGWAVDPFGHSATMPYLLKKANVTSMLIQRIHYSIKKHFSSTRSLEFMWRQAWDPESGTDLFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAITDANVAERANVLLDQYRKKSKLFRSKVVLIPLGDDFRYDKSLEWDQQYINYQKLFDYMNS-HPEMHVQAQFGTLTDYFNAVYKANGVSQGARPPGYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYS---LAVSHARHAGMEGRYPTSDYSLLTDARRNIGLFQHHDAIAGTAKEAVVTDYGTRLLRSLIGLKRVIINAAHFLIMKNKDVYRFYQTEPFLETDDRRATQDSLPQRTLIELDSSPRYLVLFNPVEQERLCVVTVLVN---SAKVRVLTEDGQTLPVQLSAQWSSAVQM------SGEVYQASFMARLPALGLAVFHLYDSVDSPMTLRSDTLLRLPGRSQTVRGVDPLPVRSQIADPQPFYIQTQSLTLAFSGTTGLLESIRRKDDPQEVRVQVQFFTYGTRPSKDKSGAYLFLPDGN-AKPYTQRDPPIVRVVEGPLFAEVVTYYQHFQQTV-RIHNVPGVDGLSLDITTL-VDIRDQTNKELSMRLHTDIQSEDTFYTDLNGFQIQPRR--------YFQKLPLQANFYPMPTMAYI-----QDSQYRLTLHTAQALGVTSLASGQLEVMLDRRLMQDDNRGLGQGVKDNKRTAN 984
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 784.637 bits (2025), Expect = 0.000e+0 Identity = 434/999 (43.44%), Postives = 615/999 (61.56%), Query Frame = 2
Query: 116 TTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL--SQQNRTDLNKKIISMAMK-MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLV-----PITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXX----XXXXXXXINSKDKIVIGNKYLKLTYD--NGFXXXXXXXXXXXXXXITQDMRYYFSYQG---NGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNI---SKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQ-----FGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNS------TND---NYQNFFTSNQMI-VTLFPGQIRTFKIVSK 2998
+ C N C P+++NVH + HTHDDVGWLKTVD+YYYG +++IQ AGVQYIL++VI AL +NP+R+F YVE+A+ RWW+QQ +R RV+ L+++GRL+ + GGWCMNDEATTHY IIDQM+LGL F++ FG C RP V+W IDPFGHS EQA++FA MGFDG FF RLDY+DKEQR+ K ME + + S LFT VL++ Y PPGFCFD C D+PI DDP+L +YNV R DF V KQ+K Y+TNH+++ MG DFQ++NAN F NLDKLI +VN+L+ +N+ YSTP CY +NK +K DDFFPYA GP+ +WTGYFTSR ALK F + SNN+ QVC QL V+ S R L + + + MGVAQHHDAVSGTEKQ VA+DYA RLS G C+ +++++LS L +C LNIS C +++ S TV++YNPLG + E R+PVN G Y + +G+ + S+ + P+++ T+ + R A+ EL FQ+ +P LG+A ++ R+ + + + + + I I N+Y LT+D +G L ++ N +S++S+ +TQ+ +Y S +G NGQ SGAYIFRP ++E+ P+ K+ L+ EV QVFS W V RLY +E EWT+GPIP+ D GKE+++++ T + +D FFTDSNGR+I+ R+ +KR + QTEPVAGNYYPVNS +++ K+ K L TDR+ G S ++G E+M+HRR L+DD+ GV E LNE G GNGL+VRG+ + + + R + F P+ + S Q+S L LP V++L+L + + ++R+EN F + + + +F +IT + EL L+ANQ D+KR++W++ +ND +Q T + ++ +TL P +IRTF + K
Sbjct: 16 SACEQN-CPTSHPDMINVHFVPHTHDDVGWLKTVDEYYYGEKNDIQHAGVQYILDSVIPALEQNPSRRFIYVEMAFLKRWWKQQGEAMRRRVRALISQGRLEIINGGWCMNDEATTHYNGIIDQMTLGLRFVSDEFGGCARPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKEQRMKDKQMELVWRASKSMGPPVADLFTGVLFNGYNPPPGFCFDQFCDDEPIQDDPSLFNYNVDSRTSDFLKEVAKQAKFYRTNHIIMTMGSDFQYENANLWFKNLDKLITYVNQLQVNGSKVNLVYSTPTCYLNELNKANLTWTVKEDDFFPYADGPHQFWTGYFTSRPALKLFERRSNNLLQVCTQLEVIVGSGAARGPLGRGYSFLLWEAMGVAQHHDAVSGTEKQQVAYDYAVRLSLGWDSCQMLVSNALSALSGSGKPTE---ICRYLNISVCPATESAS---AFTVVLYNPLGQSVTENVRLPVN---GSRYLVQDPSGATMVSKSIIVVVFPVSDATRAV--RRTLGTASGELVFQAAIPPLGFARFSVSRAARRPAEALTGFVARGPRAGGNGAPISIKNEYYTLTFDGISGLLSNVENRKSSLSLPVTQNFYWYKSSKGDDDNGQASGAYIFRPNSSEAFPVAKSAVTHFTVDPLLQEVRQVFSPWCSQVIRLYPGKPYVELEWTLGPIPLADKIGKEVLVRFDTPLKTDGVFFTDSNGREILERRRDKRPTWPLNQTEPVAGNYYPVNSRIYI-----KDEKMQLTALTDRSQGGASIRDGSFELMLHRRLLYDDHRGVDEALNEPGVWGNGLVVRGRHLLVLEAPARSAALHRPLAQAEFMAPMPLIGPPVQAWPSSTLTQFSGLTRPLPPSVHLLTLAPWGDGS-----VLLRLENQFERDEDAALSGEVTVELTGLFSRFEITSLEELTLAANQRKADMKRMRWSTASAPTESNDIEKPWQQGQTESALLAITLQPMEIRTFNVTIK 992
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006368.1 (pep scaffold:Pmarinus_7.0:GL478975:152485:159376:1 gene:ENSPMAG00000005752.1 transcript:ENSPMAT00000006368.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 143.28 bits (360), Expect = 2.533e-37 Identity = 69/178 (38.76%), Postives = 101/178 (56.74%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK 694
L + ++ H+H+D GWLKT D+YY Q+ILN +++ L E+ R F + E+++F +WW DS R+ V+ LV G+L+F+ GGW M DEA HY +IIDQM G +L+KT G RP W IDPFGHS A + G + R+ Y K +++EF+ +
Sbjct: 131 LQIIVVPHSHNDPGWLKTFDKYYVDQ--------TQHILNHMVTKLLEDRRRSFVWAEVSFFAKWWDAADSQRRHSVRRLVERGQLEFVTGGWVMTDEANAHYFAIIDQMIEGHQWLHKTLGV--RPRSGWAIDPFGHSPTMAYVLRRAGLQAMLIQRVHYAVKRHLAHERSLEFMWR 298
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003432.1 (pep scaffold:Pmarinus_7.0:GL488094:1155:3927:-1 gene:ENSPMAG00000003140.1 transcript:ENSPMAT00000003432.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 114.005 bits (284), Expect = 7.325e-28 Identity = 57/182 (31.32%), Postives = 96/182 (52.75%), Query Frame = 2
Query: 161 LNVHIISHTHDD-VGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSF 703
L ++++ H+H+D GW+KT + Y+ + IL+ + L E+ R+F + E++Y +WW+ D+ R K L++ G+L+ + GGW M DEA H +++DQM G +L + G RP W IDPFGHS A + + G + R Y K+ +++EF + S+
Sbjct: 125 LQIYVVPHSHNDPAGWIKTFEGYFV--------EQTKRILDNAMVKLAEDSRRRFIWAEVSYLAKWWEGADAAQRATAKRLIDGGQLEIVTGGWVMPDEANVHVWAMLDQMLEGHQWLERHLGV--RPRSGWAIDPFGHSPTNAYLLRAAGIQNMLIQRTHYSVKKHLAHERSLEFHWRQSW 296
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006359.1 (pep scaffold:Pmarinus_7.0:GL478975:144942:162143:1 gene:ENSPMAG00000005729.1 transcript:ENSPMAT00000006359.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 115.161 bits (287), Expect = 2.054e-26 Identity = 126/516 (24.42%), Postives = 218/516 (42.25%), Query Frame = 2
Query: 1091 DFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-----SQQNRTDLN------KKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESV-INSSLSKLISKETVNYDFVLCNLLNISFCAISDNI-SYTKLLTVLIYNPLGVTR-------MEWHRIPVNVLHGDE--YKISHSNGSLVPSQLVPITNCTKHLPER----------PKESLANYELTFQSV------------LPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKA--PKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVG-PIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNE 2497
DFF YA + YW+GYFTSR K + + + L L S++ T L ++ + + QHHDA++GT ++ V DYA RL L+D + V ++++L L+++ + SF + +N+ Y L + R +EW R+ V + D + +GS V +Q+ P+ + + + R P LA Y LT + LP G ++ + + ++ + + + G L + + D+ +Y + + KSGAY+F P E P A P + + +G LV+EV V+ V RLYN + V + + D +E+ ++ +D++SD F TD NG Q+ R+ K+ P+ N+YPV + + ++ + L + T +AGGV S +G +E+M+ RR + DDN G+G+ L +
Sbjct: 73 DFFTYADREDHYWSGYFTSRPFFKHLDRRLEAHLRAAELLFSLASWHASRRGVTPLLPARECFARLEGARRNLALFQHHDAITGTSRELVVSDYAARLMRALADLQRVLVDATLVLLLAEPGRSAASAPSQ---PSFFFLEENVVDYDSLPNKAVIKLTSAPRSLVVHNALEWERVCVVSVRVDSPLANVLTHDGSGVLAQVDPLWSSSTGMSARAFQLQFLARVPALGLAVYRLTLDAPPVPTVRSDTTLYLPGGGPVP------PRTQPLLPLALLPPPTTQFSVETASVEAGFSGRTGMLRWVRLKAGGEPRLLRLDLLWYGTRRSK-DKSGAYLFLPD-GEGKPYESAERPVVRVTRGPLVSEVTCVYPHVQHSV-RLYNLPGVEGLSLEVSNVVDLRDQNNRELSMRVSSDVESDGNFQTDLNGFQMQPRRFWKKL--------PLQANFYPVATMALV-----QDARSRLSLLTAQAGGVASLADGQLEVMLDRRLIQDDNRGLGQGLKD 563
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002016.1 (pep scaffold:Pmarinus_7.0:GL477132:216:9947:1 gene:ENSPMAG00000001828.1 transcript:ENSPMAT00000002016.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 86.6557 bits (213), Expect = 2.240e-18 Identity = 83/333 (24.92%), Postives = 150/333 (45.05%), Query Frame = 2
Query: 2117 LETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDN---IYSKMRLESLKIFNRPVVVFSKNT---NISKFDQYSALLDNLPSGVNILSLE--------NHFNLNNEIDYQ------------IIRVENVFYQ-----FGHSIKLNFQKMFRSIKITE-VIELNLSANQFLKDVKRLKWN-----STNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI 3004
LE E VGP+ ++ +E VL+ T + + TD+NG Q+ +R F + E + NYYP+ F+ E+ E L IH++R+ GV S +G +E+MVHRR ++N LN+T IVR W+ N +Y +M L++ NRP+V+ + + + +A L LP V++LSL+ NH + + ++R+++++ + ++ + + + I V E +L+ + ++R +WN S ++ + I+T+FP +I TF + +SI
Sbjct: 28 LEQELWVGPLAMD----REAVLRTSTGLRTGRVLHTDNNGFQM-----QRRLYREFPKNE-LPRNYYPLVRTAFIEEV--MEHGMRLTIHSERSHGVASLHDGEMEVMVHRRMWNNENHDYNLTLNDTS------IVRPLFWLALARKSNSVLLYQRM---GLQLENRPLVLVGETPGQLGVVPVGRATA-LPTLPPNVHLLSLQLPGWSYSSNHQKHLKRLRRRKAGAAVADLGRVLLRLQHLYEAGEDPVLSQAATIDLKILLAPLGIVRHVEERSLTGTWDIAQLRRWQWNVTAPPSAEAAHEERMVHDDFIITIFPKEICTFFVHFESI 338
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Match: EDO37584 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFA1]) HSP 1 Score: 732.25 bits (1889), Expect = 0.000e+0 Identity = 422/1008 (41.87%), Postives = 605/1008 (60.02%), Query Frame = 2
Query: 77 IINILFFGIYSSPTTCGYNSCNPGK---PNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNY-LFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-----SQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSK--LISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLAN--YELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPK--LTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTN-----ISKFDQ-YSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVF-----YQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWN----------STNDNYQNFFTSNQMIVTLFPGQIRTFK 2986
I+ +L+ + S + C + G L +HI+ HTHDDVGWLKTVD+Y+YG ++IQ AGVQYIL++VI AL E+PN++F YVEIA+F RWW QQ+ ++ VK LV + RL+F+ GGWCMNDEA THY +IIDQM++GL F+ +TFG RP ++W IDPFGHS EQA++FA M FDG FF R+DY DK R+ + ME + +GS N +FT VLY+ Y PPGFCFD CSD PI DDP L+D NV++RV++F +Q Y++N++++ MG DF ++NAN + NLDKLI HVN+ + + FYSTP Y A++ +K DDFFPYA P+ YWTGYFTSR ALK + + +NN+ Q CKQL VL S +DL ++ ++ VAQHHDAVSGT KQHVA DYA+RL+ G +DC++++++ + K + SK F CNLLN+S C +++ +K V YNP+ + R+PVN+ + + G+ + SQL+PI+ T L K S +N YEL F+ LP LG+AS + ++ + K+ VI N+++KL + D G L S+++L S V+ + Q +Y + GQ SGAYIFRP T+ + P+ K T+ +G LV EV QVFS + V RLY E E+TVGPIP D G+E++ ++ +DI S+ F+TD+NGR++ R + R + TEPVAGNYYPVNS +F+ K+ + L + TDR+ G S K+G +E+M+HRR L DD GV EPLNE+G G GLIVRGK + + R ++ P+V F++N + ++K++ Y+ + LPS V++L+LE +N+ Y +IR+E+ F + + ++ Q +F +++++V ELNL+ANQ LKD ++WN + Q V L P QIRTFK
Sbjct: 10 ILAVLYLTCFISSSLC-FQCAEKGAGKDAEKLQIHIVPHTHDDVGWLKTVDEYFYGANNSIQHAGVQYILDSVIPALNEDPNKRFIYVEIAFFKRWWDQQNVEMQEIVKKLVLQKRLEFINGGWCMNDEAATHYNAIIDQMTVGLKFIEETFGSDARPRIAWHIDPFGHSNEQASLFAQMSFDGFFFGRIDYDDKTLRLKQQRMEMVWRGSKSGNLGKNSDIFTGVLYNGYNPPPGFCFDQFCSDQPIQDDPRLYDENVKQRVEEFIKLACEQGSQYKSNNIMMTMGSDFMYENANLWYKNLDKLIAHVNQDSR-VRAFYSTPTTYLEALHAANLTWGLKTDDFFPYADCPHCYWTGYFTSRPALKRYSRLNNNLLQACKQLEVLNGPAQSGSPSSDLLRRALA------VAQHHDAVSGTSKQHVADDYAKRLAIGAADCQALMSNVIGKKSIKSKGNAPPVFSSCNLLNVSSCPSTED---SKSFVVNAYNPIARDITSYIRVPVNL----PMSVYNPQGAAIKSQLLPISQETMTLRRMQKLSASNSKYELIFKVKLPPLGFASYFV----NTSKTSSKMYGKSFAVDPSTVIQNEFIKLEFSRDTGRLTSMTDLVSEVTTQVDQQFLWYNASVDQGQPSGAYIFRPNTSSTTPVNAGGKATFTVYQGPLVQEVRQVFSPYVSQVVRLYYGQKHAEFEYTVGPIP--DDLGREVITRFDSDIKSNKVFYTDANGREMQLRTRDFRPTWKLNNTEPVAGNYYPVNSRIFV-----KDSNRQLTLLTDRSLGGSSLKDGSVELMLHRRLLVDDKRGVDEPLNESGISGKGLIVRGKVNVVLAPPATSAATHRELGEQMMLEPIVSFAQNPSTVEKWLAKYNSLYTGVARQLPSNVHMLTLET----SNQ--YALIRLEHQFEADEDSKLSMPVNVSLQGLFTDLEVSKVEELNLAANQLLKDKHPMQWNIKSVRKSRVRVSGSAKQPSLRLANTPVELRPMQIRTFK 985
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Match: EDO40866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S628]) HSP 1 Score: 192.586 bits (488), Expect = 2.537e-50 Identity = 196/803 (24.41%), Postives = 342/803 (42.59%), Query Frame = 2
Query: 284 VISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK-----GSFLPTKIHNYLFTNVLYDSYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQF---QNANHNFVNLDKLIFHVN-RLRKDINVFYSTPACYTLAXXXXXXXX--------XXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRT----------DLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLL-----TVLIYNPLGVTRMEWHRIPVNVLHGDEY-KISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYA--SLTIIRXXXXXXXXXXXXXXXINSKDK-----------------IVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYY-FSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTII--KGDLVTEVHQVFSEWGMIVTRLYN----DSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNC-FFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGE 2485
++ L E+ + KF + EI+YF WW+ D + + + G+++ + GGW MNDEA H+ S++DQ+ G ++ G +P+ W IDPFGH+ + +GF + R Y+ K+ N+EF+ + GS H F + C P P C FD + + P + + NV +R D K++K Y+TN +L+P+G DF++ + N K+ ++N + T Y AI + + DF+ YA + YW+GY+TSR K + + + L L+ + L++ + + MG+ QHHDA++GT K V DY RL L D ++V+ + L+S + ++ I +L +V +YN L R + V++ D + S+G +V SQ + + R K S YEL F + +P LG A + + +++ T ++ DK + + N + +D+ + S + D+ + + + G +SGAY+F P + P T T+ G ++ EV +V + V RLY + + L+ + TV +N+ KE V++ +TDI + N F++D NG R+ + P+ N+YP+ + FL + N++ L + + + GV + GM+E+++ RR L DDN G+G+
Sbjct: 1 MVDFLAEHKDMKFIWAEISYFSMWWKDADPHRKKQALSQIKSGQMELVTGGWVMNDEANPHFYSMLDQLIEGHQWIKNHLGPDIKPVSGWAIDPFGHTSTMPYLLRRIGFHSMLIQRTHYQVKKHLARETNLEFMWRQIWDHGSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRVTCPWRIPPVPITEQNVAERATMLLDQYKKKAKLYKTNVVLIPLGDDFRYDLKMEPAAQYDNYQKIFNYINSHPEMHAQAQFGTLKDYFQAIYQKTGTNPGERPPNFVSLSGDFYTYADRDDHYWSGYYTSRPYYKNLDRVMEAHHRGAEMLFYLAHSHAKRAGVTHYPADKLSQLLTNARRNMGLFQHHDAITGTAKDFVVVDYGNRLHRSLQDMQNVMQECMQFLLSPNKAQEPKHILKPGEDRPAQDANPIKEVIILSSSPRSVYVYNSLPEQREQV----VSLFVSDPLVTVRDSSGDVVISQTNLVWDA------RNKISSVKYELLFVASVPPLGVAVFKVKLGSVSDAHNRPSRVTAYTRDTLDKPTSEHFNIELQAPGSEVLTMNNHLISAEFDSTTGMLKSITTKADGSRVNVDLEFMTYGTKSYGDRSGAYLFLP-DGPAKPHTVPAHTTVFFTSGKVMQEV-RVVLPNVVHVVRLYRTDGPEGHSLDIQNTVDVRSMNN---KEFVMRLRTDIQNKNREFYSDLNGFSYQRRRTLDKL--------PIQANFYPMPTMAFLEDSNHR-----LSLLSAQPNGVAGLQTGMLEVVMDRRLLQDDNRGLGQ 775
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b1 (mannosidase alpha class 2B member 1 [Source:NCBI gene;Acc:101168422]) HSP 1 Score: 742.651 bits (1916), Expect = 0.000e+0 Identity = 416/1006 (41.35%), Postives = 610/1006 (60.64%), Query Frame = 2
Query: 44 FIMAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGS-FLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLR---KDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVL-SQQNRTDLNKKIISMAMK--MGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTY--DNGFXXXXXXXXXXXXXXITQDMRYYFSYQG----NGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNE-TGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK-NTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHS------IKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDN---YQNFFTSNQMIVTLFPGQIRTFKI 2989
+ A +L + +++ CGY SC+P P +LNVH++ HTHDDVGWLKTVDQY+YG R++IQ AGVQYIL++V+ L +NP+R+F YVE A+FYRWW+QQ S+++ VK LVNEGRL+F+ GGWCM+DEA THY ++IDQM+LGL FLN+TFG CGRP V+W IDPFGH+ E A++F+ MG+DG FF RLDY+D++ R + K E + + S LP + + LFT +L + Y P GFC+D C+D PI DDP L DYNV V F KQ++ Y+TNH+++ MG DFQ++NAN + NLDKL+ HVN + +NV YSTP+CY +++ + +K DDFFPYA +++WTGYFTSR ALK + + SN+ Q C QL VL +R + S ++ M VAQHHDAVSGT KQHV DYA++L+DG C+ ++++SL+ L + C+LLN+S C ++++ +K +V +YNPL + R+PV +G Y I G+ V SQ++ ++ T+ + R A EL FQ P LGY + ++ + S S S I NK+L++ + D G + LSNL++ S+N+TQ+ +Y + G + Q SGAYIFRP + +++ + I+ +V EV Q FS W V RLY DS LE EWTVGP+P++D GKE++ + + I + F+TDSNGR+I+ R+ + R + Q+EP+AGNYYP+N+ F+ K+ L + TDR+ G GS +NG +EIM+HRR L+DD GVGEPLNE + GL+VRG+ + D D+ R + +P++ F+ + N + +++ L LP V++L+L + D ++R+E+ F Q S + +N QK+F ++ + + ELNLSANQ+ ++ RL W + + + VTL P +IRTF +
Sbjct: 16 IVAALVLTLGEVLSFPLGLEKRDSVACGYQSCHPTVPGMLNVHLVPHTHDDVGWLKTVDQYFYGDRNDIQHAGVQYILDSVVDQLLKNPDRRFIYVETAFFYRWWKQQSSSMQQTVKQLVNEGRLEFVNGGWCMSDEAATHYSAVIDQMTLGLRFLNETFGACGRPRVAWHIDPFGHAREHASLFSQMGYDGFFFGRLDYQDRDSRRSKKEQELLWRASDSLPAPMAD-LFTGILPNGYNPPTGFCWDQLCNDPPIRDDPELEDYNVDDVVQRFLQIANKQAEVYKTNHIIMTMGSDFQYENANLWYKNLDKLLLHVNSQQAKGSKVNVLYSTPSCYLQELHRANRTWPLKMDDFFPYADDAHNFWTGYFTSRPALKRYERISNSNLQTCNQLEVLGGAASRKGPFGEGDSQTLRKAMAVAQHHDAVSGTAKQHVTNDYARKLADGWQRCQVLVSNSLASLSGSSAPR---IYCDLLNVSVCPLTES---SKKFSVTVYNPLARPVVWPVRLPV---YGSAYLIKDPKGNSVDSQVLSVSKATREV--RRNRGHAANELVFQVQAPPLGYTTYSVSSLQGRPSSAASPKRGAPTS-----IQNKFLQVNFDPDTGLISGLSNLETKQSINLTQNFYWYNASDGKNSESKQPSGAYIFRPNSTVPFVISRVAQTETIQTSVVQEVRQWFSPWVSQVVRLYADSRALELEWTVGPLPVSDGLGKEVITRLDSSIKTSEMFYTDSNGREILQRRKDFRPTWQLKQSEPIAGNYYPINTRAFI-----KDDVDQLTVVTDRSQGGGSIQNGSLEIMLHRRLLYDDYRGVGEPLNEVSNIFPEGLVVRGRFMLSLDRPDSAADIYRPLGQEEVLQPLLSFTDGDLNGNTQLEFTGLKAALPPAVHLLTLSQW-----DADSVLLRLEHQF-QISESKLNSQPVTVNLQKLFSTLNVLGISELNLSANQWKDEMTRLSWTPEKEEKPYLKILEDPSAWEVTLRPMEIRTFLV 993
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:101158104]) HSP 1 Score: 276.174 bits (705), Expect = 6.150e-77 Identity = 254/1022 (24.85%), Postives = 449/1022 (43.93%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK-----GSFLPTKIHNYLFTNVLYDSYCTP-PGFC--FDDKCSDDPIMDDP------TLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNA---NHNFVNLDKLIFHVNR------------LRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLS--------QQNRTDLN--KKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCN--LLNISFCAISDNISYTKLLT--------VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYA---------------SLTIIRXXXXXXXXXXXXXXXINSK----DKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYY-FSYQGNGQKSGAYIFRPTTNESMPLTKAPKLT-IIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGP-IPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNG---LIVRGKQWIK-----FDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKI 2989
L V +I H+H+D GW+KT D+Y+ Q+ILN ++ L E+P RKF + EI+YF +WW+ + + ++ L+ EG+L+ + GGW M DEA HY ++IDQ+ G +L + G P W +DPFGHS + + R+ Y K+ +T+N+EF+ + GS H F + C P P C FD K ++ P + + NV +R D K+SK Y++ LLVP+G DF++ + + ++N KL ++N L + Y T A + + DFF YA + YWTGY+TSR K + + + + L+ L+ + R + ++ +G+ QHHDA++GT K++V DY +L L + VI ++ L+ K Y F L A D + L+ ++++NP+ R+ ++ VN + ++ +G +P QL + S ++ TF + LP LG A S T++R + ++S ++S+ I +++L L + + S + + S + +++ + + KSGAY+F P K P + +++G L +EV + + + R++N + + + I D KE+ ++ TDI SD+ F+TD NG QI R+ F Q P+ GN+YP++S ++ + ++ L +HT +A GV S+++G +E+++ RR + DDN G+G+ L + N L+ R K + +I S M L P+ V K I ++ L+ P ++L+L + N + + + ++ + Q + + T+ +LN+S+ D++ L+ S Y + +N ++L P +I FK+
Sbjct: 166 LQVFVIPHSHNDPGWIKTFDKYFTDQ--------TQHILNNMVVKLAEDPRRKFIWSEISYFSKWWETAEPQKQEAMRKLILEGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNIGVT--PRSGWAVDPFGHSATMPYLLKKSNLTSMLIQRIHYSIKKHFSSTRNLEFMWRQAWDTGSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPKPIVEANVAERAQLLLDQYRKKSKLYRSKVLLVPLGDDFRYDKSLEWDQQYINYQKLFDYMNSHPELHVQAQFGTLTDYFSALYKTTGA---AAGSRPADFPVLSGDFFAYADREDHYWTGYYTSRPFYKSLDRVIESHLRGAEILYSLAVATARHEGMEGRYPVTDYSLLVDARRAVGLFQHHDAITGTAKENVVIDYGNKLLRSLIGLKRVIINAAHFLVMKNRDFYRFYQTEAFLETDDRRATQDALPQRTLIELDPAGPRYLVVFNPIEQERLCLVKVLVNTV---RVRVLTEDGQTLPVQLSAQWGSATQM------SAEVFQATFMARLPPLGLAVFHLYDSADSPMTLRSDTLLRLSSRSVTARASDPLPVHSQLADPQSFYISSQFLTLGFSGSTGLLESIKRKDDSKEVKVQIQFMVYGTSPSKDKSGAYLFLPDGKPKPYNQKEPPVVRVVEGPLFSEVVAHYQHFEQTI-RIHNVPGVDGLSVDISTMVDIRDQSNKELSMRLSTDIKSDDIFYTDLNGFQIQPRR--------FYQKLPLQGNFYPISSQAYIQDSQHR-----LTLHTAQALGVTSFESGQLEVIMDRRLMQDDNRGLGQGLKDNKRTENRFRLLLERRSSGNKGTDSSTNSFPSIVSHMTSAILNHEVLPLPVVPKRRGIPPLKTFAPLMSRFPCDFHLLNLRSIQNKQDGLTPS-PHTALLLHRLALDCSIEAQNLGFNCTTTQG-QLNVSSLFKNLDLQLLQPVSLTLMYSSTPLANHSTISLDPMEISAFKL 1149
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b2 (mannosidase alpha class 2B member 2 [Source:NCBI gene;Acc:101167078]) HSP 1 Score: 261.536 bits (667), Expect = 2.897e-72 Identity = 269/1063 (25.31%), Postives = 474/1063 (44.59%), Query Frame = 2
Query: 92 FFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNR-VKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPT-KIHNYLFTNVLYD-SYCTPPGFCFDDKCS---------DDPIMDD--PTLHDYNVQKRVDDFADYV---IKQSKA-YQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKD--INVFYSTPACYTLAXXXXXXX-XXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTD-------LNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLT--VLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKD----------KIVIGNKYLKLTYDNG----FXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGA-----YIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVF------SEWGMIVTRLYND-------SNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDD--NFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLP--------------SGVNILSLENH-FNLNN---------EIDYQ--IIRVENVFY-----QFGHSIKLNFQKMFRSI-KITEVIELNLSANQFLKDVKRLKWNSTNDN---YQNFFTSNQMIVTLFPGQIRTF 2983
F + C ++S G+ + +I H+H DVGW+ T+ + + Y N+ ++V L + R+F VE +F WW S ++ + V+ LV +GRL+F++GG M+DEA T I QM+ G FL +TFG RP SW +DPFG S +FA GF+ R+DY K+ TK ++F+ +GS P+ +FT+ + SYCTP F + DP D P + ++ +D +A + IKQ A ++TNH+L P GCD QF N++ F N+D L+ ++N+ K+ + V Y+T + Y A+++ + DF PY++ P WTG++ SR+ LKG + +++ + L + + D K+ ++ + QHHD ++GTE VA Y Q L G+ + + ++L F+L + L+ + L V+IYNPL W N+ ++ + ++ + P++ +H +S A+Y+L L L + +IR + T + + ++ + N+ KL +D ++ V +TQD ++ Y NG + YIF + ++ +A ++ II G +VTE+ Q F S++ +T L + + L+ ++VGP+ +N E+VL+ T + ++ +TD NG Q++ KRT Y Q +A NY+P+ ++ K+ + LV+ +DRA GV S NG +E+M+HRR + N G LN++ +VR W+ + + E++++ +RPVV+ N + ++ P G N S NH +LN+ E DY ++R+ +++ + + +N +++ + + ++T + E +L+ ++R KW + ND + I+T+ P +IRTF
Sbjct: 73 FLSVLVFACCCRWSSGGRGEDQPVQTFVIPHSHMDVGWVYTIQESMHAYAANV--------YSSVTEELSKVKERRFIAVEQEFFRLWWDTVASDLQKKQVRQLVKDGRLEFIIGGQVMHDEAVTDLDDQILQMTEGHGFLYQTFGV--RPQFSWHVDPFGASATTPVLFALAGFNAHLISRIDYDLKDAMQKTKKLQFVWRGS--PSLAAQQEIFTHTMDQFSYCTPSHVPFSNSSGFYWNGVALFPDPPKDGVYPNMSLPVTKETIDAYAKTMVENIKQRAAWFRTNHVLWPWGCDKQFYNSSVQFRNMDPLMKYINQKSKEFGVTVQYATLSQYFQAVHQSNLTWDVRGSQDFLPYSTEPYQAWTGFYASRNVLKGLARRASSQLHAAEILFTRYRVHFPDGPVAKDWALDKLRALRWAVSEVQHHDGITGTESPKVADMYVQHLMQGMMGVQE-LQAAL------------FLLPHYLDNPAVENFHGAGVDQALEQHVIIYNPLA-----W-----NITTVVNITVTLAGAAVYDDEGQPVSAQIQH----SAQSNASYDLFVVVQLGGLQHRKY-LIRFSGKSGHTYEAKAVVFERRRVKDWTRTGRLRLPVLNRCYKLMFDQETNLLHSITHLYSPKKQRVMMTQD---FWEYHANGDVNAGPISDNYIFSANAS-AVRAYQAVEMQIIPGQIVTEIRQYFYRGENDSDYAYSITTLVPEFSGAGLPCHRLQQTYSVGPLQLN----TEVVLRTSTSLKNNQSLYTDDNGFQMM-----KRT-YKKFQNNTLARNYFPMVRTAYI-----KDDRSGLVLLSDRAHGVSSQANGELEVMLHRRLWNNQPWNLGYNLTLNDSS------VVRPTLWMLLGSANATSRLYQREAVELQHRPVVMPIDNPRKPRQEKTGCSSPVRPVVLPPSLHLLSLSVLGWNYSS--NHSIHLNHIHSGKDFPPEPDYDRVLLRIMHLYEEGEDPELSKPVTINIKEVLQGVGEVTMLEERSLTGTWDSAGLQRWKWKTANDEGKMKEPHQGHKDFILTISPKEIRTF 1068
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: ENSORLT00000044084.1 (alpha-mannosidase 2 [Source:NCBI gene;Acc:101174073]) HSP 1 Score: 237.269 bits (604), Expect = 5.412e-64 Identity = 222/925 (24.00%), Postives = 405/925 (43.78%), Query Frame = 2
Query: 161 LNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSY-----CTP-PGFC--FD------DKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANH---NFVNLDKLIFHVNRLRK-DINVFYSTPACYTLAXXXXXXXXXXX----XDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLN-------------KKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLS--KLISKETVNYDFVLCNLLNISFCAISDNISYTKLL-------TVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTII----------------------RXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLT-IIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGN--GLIV---RGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSK-NTNISKFDQYSALLDNLPSGVNILSLEN 2716
L + ++ H+H+D GWLKT D YY ++ILN ++ L E+ RK + EI+YF +WW + D R VK LV G+L+ + GGW M DEA +HY +++DQ+ G +L + G +P W IDPFGHS + G + R+ Y K+ K +EF+ + S+ + + + + SY C P P C FD + S + + + NV++R D ++S+ ++ LLVP+G DF++ + F N KL + ++ + I + T + Y A+++ + + DFF YA + YW+GY+TSR K + + + + L L+ + ++++ +G+ QHHD ++GT + V DY RL + V SS L+ K ++D L + D + L +++YNP R I V V D + +P Q+ + E + S ++L+F + LP L SLT+ R ++ + S ++ ++ + + NK+L++ + S+ V Q ++ N KSGAY+F P + P + P L + +G + +++ F V + + + ++ + I +E+V++ ++D+ S N F+TD NG Q+ R+ K+ P+ N+YP++S FL + ++ L + + ++ S ++G +E+++ RR DDN G+G+ + + G+ L++ R Q + ID++ LESL + + P+++F++ + + K + L +LP V++L+L
Sbjct: 151 LELFLVPHSHNDPGWLKTFDGYYQDQ--------TRHILNNMLLKLGEDSRRKMIWAEISYFSKWWNEIDEQKRMMVKRLVEAGQLEMVTGGWVMADEANSHYFALLDQLMEGHQWLQRHLGL--KPSSGWAIDPFGHSPSMTYLLKGAGLRNMVIQRIHYAVKKHFAQKKTLEFLWRQSWDSSHSSDITCHMMPFYSYDVPHTCGPNPAVCCQFDFYRLPGGRTSCPWRIPPQPITEKNVKERAHVLLDQYRQKSRLFRIPVLLVPLGDDFRYVESGEWDAQFNNYQKLFDYFDQHPELHIKARFGTLSDYFSALHRRLSATETSLPTLSGDFFTYADRDDHYWSGYYTSRPFYKRLDRALESTLRATEILFSLTLAEMRRFHGDLVVGFPAREHFQRLVEGRRNLGLFQHHDGITGTGRDPVVVDYGTRLFHAILHLRQVQQSSAHWLLLLDKNQYHHDQSKPFLQTDDVISAQDALPQKTPLVLSDEPRVLIVYNPTEQRRSS--VISVVVSSPDARVVDSETAQPMPVQISAVWV------EPQQVSSQAFQLSFVAELPPL---SLTVYHVTKAPAGSTPRSTYVIHRHGNRPSIASQHFQLSRLEAAEAQTHLSLSNKHLQIWSSPETGLLQKLRLSSGLVRRVQVKFLWYGTTTNRDKSGAYLFLPGQGGAQPYSSEPPLVRVSRGPIFSDITSCFQHVTHTVRLFHLEGHSGKSIEISNMVDIRAETNRELVMRLESDVASSNRFYTDLNGFQMQQRRTLKKL--------PLQANFYPMSSSSFLQDSLSR-----LTLLSAQSQAAASLQSGELEVILDRRLQQDDNRGLGQGVTDNKLTGSLYHLLLEDRRAVQEVGGATIDHLSLLAHLESLSLCHPPIIMFAQSDIQLPKLRPFLPLHSSLPCDVHLLNLRT 1041
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b2 (mannosidase alpha class 2B member 2 [Source:NCBI gene;Acc:101167078]) HSP 1 Score: 72.7886 bits (177), Expect = 1.088e-13 Identity = 41/135 (30.37%), Postives = 68/135 (50.37%), Query Frame = 2
Query: 92 FFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTV-RNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMS 493
F + C ++S G+ + +I H+H DVGW+ T+ + + Y N + ++V L + R+F VE +F WW S + + +V+ LV +GRL+F++GG M+DEA T I QM+
Sbjct: 3 FLSVLVFACCCRWSSGGRGEDQPVQTFVIPHSHMDVGWVYTIQESMHAYAAN--------VYSSVTEELSKVKERRFIAVEQEFFRLWWDTVASDLQKKQVRQLVKDGRLEFIIGGQVMHDEAVTDLDDQILQMT 129
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000045085.1 (SMESG000045085.1) HSP 1 Score: 1946.01 bits (5040), Expect = 0.000e+0 Identity = 981/985 (99.59%), Postives = 985/985 (100.00%), Query Frame = 2
Query: 50 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI 3004
MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDF+DYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAINKIGKKLKIKNDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRSKKSNSFTKSSTIKNINSKDKIVIGNKYLKLTYDNGFLVSLSNLQSNVSVNITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVI+TDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEV+ELNLSANQFLK+VKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI
Sbjct: 1 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFSDYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAINKIGKKLKIKNDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRSKKSNSFTKSSTIKNINSKDKIVIGNKYLKLTYDNGFLVSLSNLQSNVSVNITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIYTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVVELNLSANQFLKNVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI 985
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000045072.1 (SMESG000045072.1) HSP 1 Score: 1814.28 bits (4698), Expect = 0.000e+0 Identity = 923/985 (93.71%), Postives = 924/985 (93.81%), Query Frame = 2
Query: 50 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXXXXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI 3004
MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQ STVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAINKIGKKLKIKNDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRSKKSNSFTKSSTIKNINSKDKI NK + N F NE LT IIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI
Sbjct: 1 MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQGSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQSKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAINKIGKKLKIKNDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQNRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRSKKSNSFTKSSTIKNINSKDKIT-DNKRI-----NAF-----------------------------------------NEGPKLT------IIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENVFYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLKDVKRLKWNSTNDNYQNFFTSNQMIVTLFPGQIRTFKIVSKSI 932
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000032135.1 (SMESG000032135.1) HSP 1 Score: 432.18 bits (1110), Expect = 1.446e-135 Identity = 278/915 (30.38%), Postives = 466/915 (50.93%), Query Frame = 2
Query: 185 THDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFI-QKGSFLPTKIHNYLFTNVLYDSYCTPPGFCFDDKCSDDPIMDDPTLHDYNVQKRVDDFADYVIKQ-SKAYQTNHLLVPMGCDFQFQNANHNFVNLDKLIFHVNRLRKDINVFYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQN----RTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINS---SLSKLISKETVNYDFVLCNLLNISFCAISDNISYTKLLTVLIYNPLGVTRMEWHRIPVNVLHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRXXXXX-XXXXXXXXXXINSKDKIVIGNKYLKLTYDNGFXXXXXXXXXXXXXXITQDMRYYFSYQGNGQKSGAYIFRPTTNESMPLTKAPKLTIIKGDLVTEVHQVFSEWGMIVTRLYNDSNILETEWTVGPIPINDSKGKEIVLQYQTDIDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFLAELNNKERKKSLVIHTDRAGGVGSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDNIYSKMRLESLKIFNRPVVVFSKNTNISKFDQYSALLDNLPSGVNILSLENHFNLNNEIDYQIIRVENV-------FYQFGHSIKLNFQKMFRSIKITEVIELNLSANQFLK 2878
+H + WLK + + + ++ ++ + N+V AL N R+F EI++F +W++ D+T + V++ + G+ QF+ GG +NDEATTHY SII+Q+SLGL F+ FG C RPLVSWQI+P+GHS E ANI M F +F + +++ +++F+ Q T +N + +++ + P FCF C + N++ ++F +YV+K+ S H+L+P+GCDF FQ A F N DK+I VN +K VFYSTPACY AI+ K L+I DFFP+ +W G+++SR LK ++ + + Q CK + LS + +T L ++ ++ + QH+D ++G +A + LS + C + + S KL S + F C + SFC+++DNI K++ ++++NPL W +PVN+ Y++ +L+P +VPI + R +S A Y + F++ LP GY +I R +K+ F K K++ K+ I I N + ++ + + QS Y + SG ++ N S + P I+ G LV E+ + +S + RL+ D + +E EW +G I N + +E VL Y +D+ +N FFTDSNGRQ+I R + K + N+YP+ SHV + N R +++IHTDR+ VG +E++++R L D + L E GA+ L V G+ WI+ D + RL+S +IF +P+++F KN + + + + P +NIL+LE F N+ + ++R+EN+ ++++++ + F ++ I E IE+NL+ ++ LK
Sbjct: 2 SHLENSWLKELGELFKCTEIHMNKVNIKTLFNSVYLALKINSTRRFIITEISFFQQWYEDLDTTQKATVRIFFDRGQFQFVSGGIVINDEATTHYSSIINQISLGLKFIKVNFGVCARPLVSWQINPYGHSREVANILKKMDFKAIFLGHV-----PSKLSNFDLDFLWQTKDTNDTNFNNTILASIITNGLVAPKMFCFHGHCQN------------NLKSASENFINYVMKRISLQNNKKHILIPIGCDFHFQQALETFQNFDKIIDTVNSKQKVFRVFYSTPACYLEAISNSVKTLQIYKSDFFPFDKSMKEFWIGFYSSRPNLKLIIRLAESYIQTCKMITALSDKEFNRRKTKLINDLVYLSNLISKTQHYDYITGNHPGQIAQLKIKELSSAIKMCHDLSAAGVESTMKLKSSNRKSMLFFDCPYHDFSFCSLTDNIQLNKIVNLIVFNPLPYPHTVWIYLPVNLDIHQTYEVKDVWNTLLPIDIVPINKMILNNINRQPKSKAKYNIYFKAQLPETGYTIFSIRRKRKNFWDFNKVLVSKSLILKNNIYISNSIINVSLNLKTNRLIIQKQSRKISLFLGIKCYCTNLDVVNASSGVFVSELKDN-SQAIHSKPTSYILDGSLVKEIRRRYSNGIGLTIRLFEDQDNVEIEWIIGGIDENSNFNREYVLTYNSDLSINNQFFTDSNGRQLIKRFLKKGLS--------IESNFYPITSHVLV----NNSRNLAMLIHTDRSVAVGGKTPNSVELLINRIILSSDKGSFNKQLKEVGANRKILSVIGRNWIEIGSTDELIINRRLKSNEIFKKPLLMFKKNNIAEYYLKIFSHVKTQPRHLNILTLEPIFEPNSNVGLILLRLENLKDVSRNEIRNRINTVRVDLKHFFENLNILEAIEMNLAGDKELK 886
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000018139.1 (SMESG000018139.1) HSP 1 Score: 175.637 bits (444), Expect = 2.052e-44 Identity = 151/531 (28.44%), Postives = 247/531 (46.52%), Query Frame = 2
Query: 182 HTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK---GSFLPTKIHNYLFTNVLYD--SYCTP-PGFCFDDKCSDD---------PIMDDPT-LHDYNVQKRVDDFADYVIKQSKAYQT-NHLLVPMGCDFQFQNANH---NFVNLDKLIFHVNRLRKDINV---FYSTPACYTLAXXXXXXXXXXXXDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQ-------------NRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVN--YDFVLCNLLNI-SFCAISDNISYTKLLT-----VLIYNPLGVTRMEWHRIPVNV-LHGDEYKISHSNGSLVPSQLVPI 1639
H+H D GW+KTVD+Y+ +D+ Q ILN+++ L + PN KF + E+ YF +WW +++VK L+ +L+ + GGW M DEAT HY S+I+Q++ G +L P W IDPFG+S + G + + R+ Y K++ ++K +EF K S I+ ++ YD C P P C C D P +DP + D NV+ R + D K++ Y N++LVP+G DF+++ + N KL+ ++N+ +K+ NV F + K + D F YA + YWTGYFTSR LK + N + + + LS N++ L++KI + + QHHDAV+GT K HV D+ +L + + + V + +++ N +D ++ ++ N+ S+ + ++ + T V ++N L R IP+ V KI S L+ Q+ PI
Sbjct: 162 HSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNK-QKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPI 677 The following BLAST results are available for this feature:
BLAST of Alpha-mannosidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Alpha-mannosidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30006606 ID=SMED30006606|Name=Alpha-mannosidase|organism=Schmidtea mediterranea sexual|type=transcript|length=3119bpback to top protein sequence of SMED30006606-orf-1 >SMED30006606-orf-1 ID=SMED30006606-orf-1|Name=SMED30006606-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=986bp MAFILVVSLIINILFFGIYSSPTTCGYNSCNPGKPNVLNVHIISHTHDDVback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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