NEK8-2

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD--------SSDNVDTAKPQTRNYEFEKRSV---------------VYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL----VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT----INSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +E+IR VG+GA+G   L  +K D  LVI+K+I +  ++  ERQ A NE +VL  L+HPN++ Y+++F ED  LMI MEYA  GTLA+F+  +    LEE+ IL  F QI+ A+H++H H ILHRDLKT NI L K   ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++L+ SLL   P  R     I+   L +  +   HTD        +  +V  +   +R      R +               VY      L  +P+RLP     + Q+ +G      +T    +  W +   G  G G L    V++ +P+ +S   +     ++  +ACG+ F+    + GIIMT GSG +G LGHG   D+ +P ++E+LL  ++V ++   SHV+ +S+E  ++ WG   +G+LGL +   +  PQ +        +      D++M+LT                G N      +   SL ++P     +     FT + +    +  +  + +G  H+  +  SG    FG N  GQLG  + + S  PC+V+ ++  K+  V  G  FTVA    + +Y WG
Sbjct:    4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWG-GGLG-TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-GGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT--------VPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTL-AQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKG--QFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSD----NVDTAKPQTRNYE-------FEKRSVVYVMDINTLNLSPVRL---PSKIRIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFK--DVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNS-PIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +G+GA+G A LYR+ +DDSLV+ KE+++  LS  ER+ A+NE+ +L+ L H NI+AY++ F ++  L+IE+EY + G L  + L  ++K  EE+ ++   FQIVSA+  IH+  ILHRD+KT+NIFLTK  +IK+GD+G++K L++ +  A +++GTPYY+SPE+CQG  YN KSD+WA+GC+++E+  L +TF+ +N   L  KI++G    E     YS EL +++ S L+++P+ R + + +L    P++ K            N  T +P++             + S VYV        +P +L    S    +Q+C+G  H  V+T ++ ++TW     G+   GQLGHGD    ++P+ V  L  K++ +++CG+DF++   + G +   GS   G +G       +VL+P  +   L+  V  +S  ++HVVV++    +Y WG  + G+LGLDS   Y +PQ +   + +++       D T LLT++G +LA G N  NKLGLN  +  ++  ++  + P   S   FT  + +  + +  ++ GK HT  + E G+++ FG N  GQLG G+ K    I      +   ++ +V+ G  FT+A  D N ++ WG
Sbjct:   55 IRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDR--PLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGG--KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS---FTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD 1520
            +E+IR VG+GA+G   L  +K D  LVI+K+I +  ++  ERQ A NE +VL  L+HPN++ Y+++F ED  LMI MEYA  GTLA+F+  +    LEE+ IL  F QI+ A+H++H H ILHRDLKT NI L K   ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++L+ SLL   P  R     I+   L +  +   HTD
Sbjct:    4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTD 268          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEII-KIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            ++ ++ I+ +G+GA+G A L + K D    ++KEIN   +   E++ +  EV +L ++ HPNIVA+F+SF+E+G L I MEY D G L + ++ Q   L  E +IL  F QI   + +IH+ KILHRD+K  NIFL+K  ++ K+GDFGI+++L+ + E A + IGTPYY+SPE+CQ K YN K+D+W+LGC+LYE+  L   FEG+NL  LV KI +  F P+   +S EL  LIS L + +P DR S   IL
Sbjct:    1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSIL 254          

Query:  738 KIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            +++ +G+G++G A+L +  +D    ++KEIN+  +S+ ER+ +  EV VL+ + HPNIV Y +SFEE+G L I M+Y + G L + ++ Q+  L +E +IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  +++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYE+  L   FE  ++  LV KI+ G F PV   YS +L+ L+S L ++NP DR S   IL
Sbjct:    6 RLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSIL 253          

Query:  726 NGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTT--HEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPV-RLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPC--EVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDM 2576
            N +E+IRTVGKGA+G+AVLYR+++D SLVI+KEINM+DL +++R+LA+NEV +LS+++HPNI+AY+DSFEE+GVLMIEMEYAD GTLAQ LS  +  L+E++I +M  Q+ SA+ Y+HE+ +LHRDLKT N+FLT++  +KIGDFGISK++ T    +GA +V+GTPYYISPEMC G  YNEKSD+WALGCILYEM CL K FEG NLPALVN I+   + PVKG YS E+K +I  LL+ +P  R S         P  +K      + +  T+     +  F   + +Y + + T+ LS +  LPS+I IKQ+   + HT+VLT D  +F +G N  GQLG G     +   LV SL  + +  +  GN FS+   + G ++T G+  +  LG  D KD  KP L+E LL  ++  I   + HVV V       GWGSN+ GQLGL +L  + +P  I    +  +      +DATMLL++ G L+A G+N  NKL L  R+GF    K   + P  + V++ T ++      V+  S+G  H+ V+ ESG+++ FG N + +LG G+++   + C   VK++  H  T V  G  FT+       LYFWG +     D+
Sbjct:  131 NRYERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSA--------PQALKMLRPSENRHRHTSGSMRSSVSF---TTLYDLHVPTITLSSIPDLPSRISIKQVALSKTHTMVLTNDNELFGFGDNSCGQLGFGKFSKMENGRLVESLKGRDIQSVGVGNYFSVICCDRGTLLTFGTAKNLGLGK-DAKDSAKPMLLEQLLRENIKDIYCGHDHVVAVLESGECLGWGSNQYGQLGLPTLEHFFAPTKIPMPSNKKIVYGKAGKDATMLLSDDGSLIAMGSNKHNKLNLTQRVGFFTKEK---KTPN-DYVNKPTILQGFPERVVD-FSVGSYHSGVILESGQVMIFGRNDNTELGLGNSQKMAVRCVKPVKSLLHHACTHVLCGDGFTLVSTTEQELYFWGRKDLTDEDV 735          

Query:  726 NGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTT--HEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPV-RLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPC--EVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDM 2576
            N +E+IRTVGKGA+G+AVLYR+++D SLVI+KEINM+DL +++R+LA+NEV +LS+++HPNI+AY+DSFEE+GVLMIEMEYAD GTLAQ LS  +  L+E++I +M  Q+ SA+ Y+HE+ +LHRDLKT N+FLT++  +KIGDFGISK++ T    +GA +V+GTPYYISPEMC G  YNEKSD+WALGCILYEM CL K FEG NLPALVN I+   + PVKG YS E+K +I  LL+ +P  R S         P  +K      + +  T+     +  F   + +Y + + T+ LS +  LPS+I IKQ+   + HT+VLT D  +F +G N  GQLG G     +   LV SL  + +  +  GN FS+   + G ++T G+  +  LG  D KD  KP L+E LL  ++  I   + HVV V       GWGSN+ GQLGL +L  + +P  I    +  +      +DATMLL++ G L+A G+N  NKL L  R+GF    K   + P  + V++ T ++      V+  S+G  H+ V+ ESG+++ FG N + +LG G+++   + C   VK++  H  T V  G  FT+       LYFWG +     D+
Sbjct:  169 NRYERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSA--------PQALKMLRPSENRHRHTSGSMRSSVSF---TTLYDLHVPTITLSSIPDLPSRISIKQVALSKTHTMVLTNDNELFGFGDNSCGQLGFGKFSKMENGRLVESLKGRDIQSVGVGNYFSVICCDRGTLLTFGTAKNLGLGK-DAKDSAKPMLLEQLLRENIKDIYCGHDHVVAVLESGECLGWGSNQYGQLGLPTLEHFFAPTKIPMPSNKKIVYGKAGKDATMLLSDDGSLIAMGSNKHNKLNLTQRVGFFTKEK---KTPN-DYVNKPTILQGFPERVVD-FSVGSYHSGVILESGQVMIFGRNDNTELGLGNSQKMAVRCVKPVKSLLHHACTHVLCGDGFTLVSTTEQELYFWGRKDLTDEDV 773          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDS--LVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFL--------SNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPV 1388
            ++ +EK+R VG+GA+G   L R K+D S   VI+K IN H ++  E     +EV +L ++ HP I+ Y DSF  D  L I M+YA+ GTL + +        SN  +   EK +L+ F QI+ A++++H+  I+HRDLK  NI + + + ++K+ DFGISK L T    A++VIGTP Y+SPE+C+ + YN+KSD+W+LGC+LYE+  L + F+G NLPA+V KI + +  P+
Sbjct:    1 MDNYEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTK-SAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPL 232          

Query:  744 RTVGKGAYGTAVLYRKKDDDSLVILKEINMHDL-SATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKP---LEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGS--NLPALVNKILKGQFEPVKG 1394
            + +GKG +      +    D  V LK+I + ++     RQ  + E+ +L QL+H N++ Y+ SF ++  L I +E A+ G +++ + + +K    + EK I + F Q+  A+ ++H  +I+HRD+K  N+F+T   I+K+GD G+ +  S+    A+S++GTPYY+SPE  Q   YN KSD+W+ GC+LYEM  L   F G   NL +L  KI   ++ P+  
Sbjct:   27 KKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPA 249          

Query:  744 RTVGKGAYGTAVLYRKKDDDSLVILKEINMHDL-SATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKP---LEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGS--NLPALVNKILKGQFEPVKG 1394
            + +GKG +      +    D  V LK+I + ++     RQ  + E+ +L QL+H N++ Y+ SF ++  L I +E A+ G +++ + + +K    + EK I + F Q+  A+ ++H  +I+HRD+K  N+F+T   I+K+GD G+ +  S+    A+S++GTPYY+SPE  Q   YN KSD+W+ GC+LYEM  L   F G   NL +L  KI   ++ P+  
Sbjct:   27 KKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPA 249          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLE--EKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTD------------SSDNVDTAKP----------------QTRNYE------------FEKRSVVYVMDI--NTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKK-PELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXX-XXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIR 2555
            +EK+R VG+G++G A+LYR+K D   ++ K+IN+ +LS   R LAMNEV V S+L HPNIV+Y  SF +D  L+IEMEYAD GTLAQ ++ ++  L   E+ I+ +F QI SAI+Y+H   ILHRDLKT N+FL +  I+KIGDFGISK+++T    A +V+GTPYY SPEMC+GK Y+ KSD+WALGCIL EM CL KTF  SNL  LV KI+ G + PV   Y+  L+ L+S+LL+     R +   +L + +P++ ++   +             SD +    P                QT   +             EKRSV+Y +       +++P++LP K  I  +   ++H +V+  D + + WG    GQLG   L   K  P  + S+    ++    G+ F+I   + G +++CGS    +LG  + ++   P+LI  L  + V  ++A   HV+ +S E  +Y WG++  G LGL +       Q   F + +L+ +  T         +T  +L A+G  +        +LGF  + K          +  F KV+  + H V Q      H+  L E G +   G N+ GQ G     +   P  V ++K   I K       T+   + N +  WG R
Sbjct:  105 YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQ-----QQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAK----------ITAFKKVQ--LPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGTR 740          

Query: 1638 SKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKK--------------------PELVSSLTQKSLIRIACGNDF--------------------------------SIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVIT 2099
            + +R++Q+ +G  H + L+ +  V+ WG++  G LG G+   ++K                    P+  + L     + +   ND+                                S+F  E G + T G    G  G      V  P L++S+ +  +V  + ++   +V S +++I  WG+ +NG  G+ S N     Q+ T
Sbjct:  555 ADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT-RNGLPGIGSTNCGLGLQICT 759          

Query:  714 QQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSF--EEDGVLMIEMEYADNGTLAQFLS---NQEKPLEEKKILEMFFQIVSAIHYIHEH----KILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKL 1490
            Q+T+  +E +  +G G++GT    R K    L   K +N  +L   +    ++E+ VL QL HPNIV Y+      E   + I ME    G LAQ +    +Q +  EE  I  + FQ+  A+   H       ILHRD+K  NIFL      K+GDFG+++ML      A S +GTP+Y+SPE+ +G+ Y+ KSDVWA+GC++YEM  L   F G     L  KI +G+F  +   YS +L+E+I+ +L  + + R   EVI+ H L
Sbjct:   13 QKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPL 280          

Query:  627 DIIIEHESHPSKI-----AAKFYFSINNLISFSI-----QQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYN-EKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFE 1382
            +++  H +HPS I     +AK   ++    S  +     ++ I  ++ I+T+GKG +    L +       V +K I+   L+    Q    EV+++  LDHPNIV  F   E +  L + MEYA  G +  +L    + ++EK+    F QIVSA+ Y H+ +I+HRDLK  N+ L  E  IKI DFG S    T     ++  G+P Y +PE+ QGK Y+  + DVW+LG ILY +      F+GS L  L  ++L+G++ 
Sbjct:  208 NVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGR-MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEF-TPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYR 468          

Query:  627 DIIIEHESHPSKI-----AAKFYFSINNLISFSI-----QQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYN-EKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFE 1382
            +++  H +HPS I     +AK   ++    S  +     ++ I  ++ I+T+GKG +    L +       V +K I+   L+    Q    EV+++  LDHPNIV  F   E +  L + MEYA  G +  +L    + ++EK+    F QIVSA+ Y H+ +I+HRDLK  N+ L  E  IKI DFG S    T     ++  G+P Y +PE+ QGK Y+  + DVW+LG ILY +      F+GS L  L  ++L+G++ 
Sbjct:  208 NVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGR-MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEF-TPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYR 468          

Query:  627 DIIIEHESHPSKI-----AAKFYFSINNLISF-----SIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYN-EKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFE 1382
            +++  H +HPS I     +AK   ++    S      + ++ I  ++ I+T+GKG +    L +       V +K I+   L+    Q    EV+++  LDHPNIV  F   E +  L + MEYA  G +  +L    + ++EK+    F QIVSA+ Y H+ +I+HRDLK  N+ L  E  IKI DFG S    T     ++  G+P Y +PE+ QGK Y+  + DVW+LG ILY +      F+GS L  L  ++L+G++ 
Sbjct:  208 NVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGR-MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEF-TPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYR 468          

Query:  705 FSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKL---PMMMKTFHTDSSD-----------NVDTAKPQTR--NYEFEKR------SVVYVMDINTLNLS-----------PVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGD-----LVDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT----INSVHEFTKVEAVMRHC--VNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            F   + +  +EKI+ VG+GA+G   L R++ D +LVILKEI +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA ++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+ H +   P++    +TD  +           NV  A P  R   +    R      S+     ++ L LS           P+RLP     + Q+  G    + +T    + TW   E   +G G+      V++ +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V +S   SHV+ V++E  ++ WG   NG+LGL + + +  PQ ++       +      D +M+++          +     G N      +   S +++P+    +  VH F  V++   +   +  + +G  H+  + E G+   FG N  GQLG    ++S +P +V  ++   IT    G  FT+A      +Y WG
Sbjct:   41 FGASENMEKYEKIKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIRPLL--NLYTDIGNVKMRRIEKPLSNVQ-AGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLSSVYTWGSGISTPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMS--------TQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQ--GITMAACGDAFTLAIGAEGEVYTWG 689          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKL---PMMMKTFHTDSSD-----------NVDTAKPQTR--NYEFEKR------SVVYVMDINTLNLS-----------PVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGD-----LVDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT----INSVHEFTKVEAVMRHC--VNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EKI+ VG+GA+G   L R++ D +LVILKEI +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA ++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+ H +   P++    +TD  +           NV  A P  R   +    R      S+     ++ L LS           P+RL      + Q+  G    + +T    + TW   E   +G G+      V++ +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V +S   SHV+ V++E  ++ WG   NG+LGL + + +  PQ ++       +      D +M+++          +     G N      +   S +++P+    +  VH F  V++   +   +  + +G  H+  + E G+   FG N  GQLG    ++S +P +V  ++   IT    G  FT+A      +Y WG
Sbjct:    4 YEKIKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIRPLL--NLYTDIGNVKMRRIEKPLSNVQ-AGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLSSVYTWGSGISTPLRLSMLNTEVIQVSLGRTQKMGVTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMS--------TQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQ--GITMAACGDAFTLAIGAEGEVYTWG 643          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR 1559
            ++ +E+++ +G+G++G A+L + + D    ++KEI +  +S  ERQ +  EV VL+ + HPNIV Y +SFEE G L I M+Y + G L + ++NQ   L  E++IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  +++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYEM  L   FE  N+  LV KI++G + PV   YS +L+ L++ L ++NP +R S   IL    P + +  H   S  V     QTR
Sbjct:    1 MDKYERLKKIGEGSFGKAILVKSRTDGRQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEESGCLYIVMDYCEGGDLFKKINNQRGSLFPEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSIHYSPDLRSLLAQLFKRNPRERPSVSTILDK--PFLARRIHKFLSPQVTYTHEQTR 278          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFE-EDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHH 1484
            ++G+  +R VGKG+YG   L R K D    ++K++N+   S  ER+ A  E ++LSQL HPNIV Y +S+E ED  L I M + + G L   L  Q+  L  E++++E F QI  A+ Y+HE  ILHRDLKT NIFLTK  IIK+GD GI+++L   ++ A+++IGTPYY+SPE+   K YN KSDVWALGC +YEM  L   F   ++ +LV +I++G+   +   Y  +L ELI  +L K P+DR   + IL  
Sbjct:    1 MDGYLFVRVVGKGSYGEVNLVRHKSDRKQYVIKKLNLRTSSRRERRAAEQEAQLLSQLKHPNIVMYRESWEGEDCQLYIVMGFCEGGDLYHRLKQQKGELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIVEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQ 256          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFE-EDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHH 1484
            ++G+  +R VGKG+YG   L R K D    ++K++N+   S  ER+ A  E ++LSQL HPNIV Y +S+E ED  L I M + + G L   L  Q+  L  E++++E F QI  A+ Y+HE  ILHRDLKT NIFLTK  IIK+GD GI+++L   ++ A+++IGTPYY+SPE+   K YN KSDVWALGC +YEM  L   F   ++ +LV +I++G+   +   Y  +L ELI  +L K P+DR   + IL  
Sbjct:    1 MDGYLFVRVVGKGSYGEVNLVRHKSDRKQYVIKKLNLRTSSRRERRAAEQEAQLLSQLKHPNIVMYRESWEGEDCQLYIVMGFCEGGDLYHRLKQQKGELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIVEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQ 256          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHK--LPMMMKTFH------------TDSSDNVDTAKPQTRNYEFEKR-----------------SVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            ++KIR VG+GA+G   L  +K D  LVI+K+I +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A+H++H   ILHRDLKT NI L K + I+KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+T L + FE +NLPALV KI+ G F P+   YS EL+ LI S+L  +P  R     I+ H   +P ++  +               S   V   +P +R      R                 S VY         +P+RLP     + Q+ +G      +T    +  W +   G  G   L   ++  +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGH +F DV +P+++E LL  ++V +S   SH + VS+E  ++ WG   NG+LGL S   Y SPQ +        +      D++M+LT    LLA G+N  NKLG +     +++    S +  +   + FT +++    +  +    +G  H+ V+   G+   FG N  GQLG  + +NS +PC V  ++  K+T V  G  +TVA      ++ WG
Sbjct:    4 YKKIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIVMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKHQMIVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNEIMAHPICIPALLNLYSDIGSVKMRVEKPLASVPAVSRVRPASRIPSARSRGGRVGHSPAKPGIPPPLSSVYTWGSGI--STPLRLPMLNTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT-GAPSLPGSIEHAQPQFISRFLEGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDR----ILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWG 644          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE-----SLLTIDVVCISATNSHVVVVSSEDV 2018
            G +H+ V+T     +T+GSN+ GQLG     + + P LVS+L    +  +ACG+ +++     G + T G G  G LG  D + +  P++++     S +   V C        V  S ED+
Sbjct:  575 GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWGKGARGRLGRRD-EGIGIPKIVQLEENHSYVVTSVACCHGNTLLAVKPSLEDI 695          

Query:  720 TINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHK--LPMMMKTFH-------------TDSSDNVDTAKPQTRNYEFEKR-----------------SVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            T+  +  IR +G+  +    L  +K D  LVI+K+I +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A+H++H   ILHRDLKT NI L K + I+KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+T L + FE +NLPALV KI+ G F P+   YS EL+ LI S+L  +P  R     I+ H   +P ++  +                S   V   +P +R      R                 S VY         +P+RLP     + Q+ +G      +T    +  W +   G  G   L   ++  +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGH +F DV +P+++E LL  ++V +S   SH + VS+E  ++ WG   NG+LGL S   Y SPQ +        +      D++M+LT    LLA G+N  NKLG +     +++    S +  +   + FT +++    +  +    +G  H+ V+   G+   FG N  GQLG  + +NS +PC V  ++  K+T V  G  +TVA      ++ WG
Sbjct:    2 TLMRYPSIRPMGQIVH----LCLRKADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIVMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKHQMIVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNEIMAHPICIPALLNLYSDIGSVKMRRVEKPLASVPAVSRVRPASRIPSARSRGGRVGHSPAKPGIPPPLSSVYTWGSGI--STPLRLPMLNTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT-GAPSLPGSIEHAQPQFISRFLEGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDR----ILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWG 643          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE-----SLLTIDVVC 1970
            G +H+ V+T     +T+GSN+ GQLG     + + P LVS+L    +  +ACG+ +++     G + T G G  G LG  D + +  P++++     S +   V C
Sbjct:  574 GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWGKGARGRLGRRD-EGIGIPKIVQLEENHSYVVTSVAC 678          

Query:  720 TINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHK--LPMMMKTFH-------------TDSSDNVDTAKPQTRNYEFEKR-----------------SVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            T+  +  IR +G+  +    L  +K D  LVI+K+I +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A+H++H   ILHRDLKT NI L K + I+KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+T L + FE +NLPALV KI+ G F P+   YS EL+ LI S+L  +P  R     I+ H   +P ++  +                S   V   +P +R      R                 S VY         +P+RLP     + Q+ +G      +T    +  W +   G  G   L   ++  +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGH +F DV +P+++E LL  ++V +S   SH + VS+E  ++ WG   NG+LGL S   Y SPQ +        +      D++M+LT    LLA G+N  NKLG +     +++    S +  +   + FT +++    +  +    +G  H+ V+   G+   FG N  GQLG  + +NS +PC V  ++  K+T V  G  +TVA      ++ WG
Sbjct:    2 TLMRYPSIRPMGQIVH----LCLRKADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIVMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKHQMIVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNEIMAHPICIPALLNLYSDIGSVKMRRVEKPLASVPAVSRVRPASRIPSARSRGGRVGHSPAKPGIPPPLSSVYTWGSGI--STPLRLPMLNTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT-GAPSLPGSIEHAQPQFISRFLEGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDR----ILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWG 643          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE-----SLLTIDVVC 1970
            G +H+ V+T     +T+GSN+ GQLG     + + P LVS+L    +  +ACG+ +++     G + T G G  G LG  D + +  P++++     S +   V C
Sbjct:  574 GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWGKGARGRLGRRD-EGIGIPKIVQLEENHSYVVTSVAC 678          

Query:  780 LYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHK--LPMMMKTFH-------------TDSSDNVDTAKPQTRNYEFEKR-----------------SVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            L  +K D  LVI+K+I +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A+H++H   ILHRDLKT NI L K + I+KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+T L + FE +NLPALV KI+ G F P+   YS EL+ LI S+L  +P  R     I+ H   +P ++  +                S   V   +P +R      R                 S VY         +P+RLP     + Q+ +G      +T    +  W +   G  G   L   ++  +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGH +F DV +P+++E LL  ++V +S   SH + VS+E  ++ WG   NG+LGL S   Y SPQ +        +      D++M+LT    LLA G+N  NKLG +     +++    S +  +   + FT +++    +  +    +G  H+ V+   G+   FG N  GQLG  + +NS +PC V  ++  K+T V  G  +TVA      ++ WG
Sbjct:   16 LCLRKADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIVMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKHQMIVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNEIMAHPICIPALLNLYSDIGSVKMRRVEKPLASVPAVSRVRPASRIPSARSRGGRVGHSPAKPGIPPPLSSVYTWGSGI--STPLRLPMLNTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT-GAPSLPGSIEHAQPQFISRFLEGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDR----ILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWG 641          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE-----SLLTIDVVC 1970
            G +H+ V+T     +T+GSN+ GQLG     + + P LVS+L    +  +ACG+ +++     G + T G G  G LG  D + +  P++++     S +   V C
Sbjct:  572 GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWGKGARGRLGRRD-EGIGIPKIVQLEENHSYVVTSVAC 676          

Query:  786 RKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHK--LPMMMKTFH-------------TDSSDNVDTAKPQTRNYEFEKR-----------------SVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            R + D  LVI+K+I +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A+H++H   ILHRDLKT NI L K + I+KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+T L + FE +NLPALV KI+ G F P+   YS EL+ LI S+L  +P  R     I+ H   +P ++  +                S   V   +P +R      R                 S VY         +P+RLP     + Q+ +G      +T    +  W +   G  G   L   ++  +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGH +F DV +P+++E LL  ++V +S   SH + VS+E  ++ WG   NG+LGL S   Y SPQ +        +      D++M+LT    LLA G+N  NKLG +     +++    S +  +   + FT +++    +  +    +G  H+ V+   G+   FG N  GQLG  + +NS +PC V  ++  K+T V  G  +TVA      ++ WG
Sbjct:   56 RIQADQKLVIIKQIPVEQMTKDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIVMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALHHVHTKLILHRDLKTQNILLDKHQMIVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELTSLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRHLILSMLNLDPSKRPQLNEIMAHPICIPALLNLYSDIGSVKMRRVEKPLASVPAVSRVRPASRIPSARSRGGRVGHSPAKPGIPPPLSSVYTWGSGI--STPLRLPMLNTEVVQVSAGRTQKAGVTKSGRLIMWEATPVGT-GAPSLPGSIEHAQPQFISRFLEGQSGVTIKHVSCGDLFTACLTDRGIIMTFGSGSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIPPEYEAQRVVCGIDSSMILTVANQLLACGSNRFNKLGFDR----ILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILCADVGTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWG 679          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE-----SLLTIDVVC 1970
            G +H+ V+T     +T+GSN+ GQLG     + + P LVS+L    +  +ACG+ +++     G + T G G  G LG  D + +  P++++     S +   V C
Sbjct:  610 GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMVACGDAYTVAVGAEGQVFTWGKGARGRLGRRD-EGIGIPKIVQLEENHSYVVTSVAC 714          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD-------------------SSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNL--------SPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL----VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT-INSVHEFTKVEAVMRHCVNQ-----VSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +E+IR VG+GA+G   L  +K D  LVILK+I +  ++  ERQ A NE +VL  L+HPN++ Y+++F ED  LMI MEYA  GTLA+F+  +    LEE+ IL  F QI+ A+H++H H ILHRDLKT NI L K   ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++L+ SLL   P  R     I+   L +  +   HTD                   +S +  +     R     +  V   +     ++        SP+RLP     + Q+ +G      +T    +  W +   G  G G L    V+  +P+ VS   +     ++  +ACG+ F+    + GIIMT GSG +G LGHG+  D+ +P ++E+LL  ++V ++   SHV+ +S++  ++ WG    G+LGL +   +  PQ +        +      D++M+LT                G N      +   SL ++P     V E      +    ++Q     V +G  H+  +  SG    FG N  GQLG  S + S  PC V+ ++  K+  V  G  FTVA      +Y WG
Sbjct:    4 YERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-GGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSP--------GRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWG 644          

Query: 1668 GENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIE 1943
            G  H+  +T     +T+GSN+ GQLG       + P  V  L    ++ +ACG+ F++     G + + G G  G LG  D +D   PR ++
Sbjct:  575 GTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRD-EDAGLPRPVQ 665          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLA-QFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKG--QFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSD--NVDTAKPQTRNYE-------FEKRSVVYVMDINTLNLSPVRL---PSKIRIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFK--DVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNS-PIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +G+GA+G A LYR+ +DDSLV+ KE+++  LS  ER+ A+NE+ +L+ L H NI+AY++ F ++  L+IE+EY + G L  + L  ++K  EE+ ++   FQIVSA+  IH+  ILHRD+KT+NIFLTK  +IK+GD+G++K L++ +  A +++GTPYY+SPE+CQG  YN KSD+WA+GC+++E+  L +TF+ +N   L  KI++G    E     YS EL +L+ + L+++P+ R + + +L   L    +    +     N  T +P++             + S VYV        +P +L    S    +Q+C+G  H  V+T ++ ++TW     G+   GQLGHGD    ++P+ V  L  K++ +++CG+DF++   + G +   GS   G +G       +VL+P  +   L+  V  +S  ++HVVV++    +Y WG  + G+LGLDS   Y +PQ +   + +++       D T LLT++G +LA G N  NKLGLN  +  ++  ++  + P   S   FT  + +  + +  ++ GK HT  + E G+++ FG N  GQLG G+ K    I      +   ++ +V+ G  FT+A  D N ++ WG
Sbjct:   55 IRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLDLPLLRTRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGG--KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS---FTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEE-DGVLMIEMEYADNGTLAQFLSNQE-KPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHH 1484
            +R VG+G+YG   L + + D    ++K++N+ + S+ ER+ A  E ++LSQL HPNIV Y +S+E  DG+L I M + + G L + L  Q+ + L E +++E F QI  A+ Y+HE  ILHRDLKT N+FLT+  IIK+GD GI+++L    + A+++IGTPYY+SPE+   K YN KSDVWALGC +YEM  L   F   ++ +LV +I++G+  P+   YS EL ELI ++L + P++R S   IL  
Sbjct:    9 MRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQ 258          

Query:  738 KIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILH 1481
            +++ +G+G++G AVL +  +D    ++KEIN+  +S  ERQ +  EV VL+ + HPNIV Y +SFEE+G L I M+Y + G L + ++ Q+  L +E +IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  +++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYE+  L   FE  N+  LV KI+ G F PV   YS +L+ L+S L ++NP DR S   IL 
Sbjct:    6 RLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILE 254          

Query:  738 KIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILH 1481
            +++ +G+G++G AVL +  +D    ++KEIN+  +S  ERQ +  EV VL+ + HPNIV Y +SFEE+G L I M+Y + G L + ++ Q+  L +E +IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  +++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYE+  L   FE  N+  LV KI+ G F PV   YS +L+ L+S L ++NP DR S   IL 
Sbjct:    6 RLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILE 254          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD--------SSDNVDTAKPQTRNYEFEKRSV---------------VYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL----VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT----INSVHEFTKVEAVM--RHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +E+IR VG+GA+G   L  +K D  LVI+K+I +  ++  ERQ A NE +VL  L+HPN++ Y+++F ED  LMI MEYA  GTLA+F+  +    LEE+ IL  F QI+ A+H++H H ILHRDLKT NI L K   ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++L+ SLL   P  R     I+   L +  +   HTD        +  +V  +   +R      R +               VY      L  +P+RLP     + Q+ +G      +T    +  W +   G  G G L    V++ +P+ +S   +     ++  +ACG+ F+    + GIIMT GSG +G LGHG   D+ +P ++E+LL  ++V ++   SHV+ +S+E  ++ WG   +G+LGL +   +  PQ +        +      D++M+LT                G N      +   SL ++P     +     FT + +    +  +  + +G  H+  +  SG    FG N  GQLG  + + S  PC+V+ ++  K+  V  G  FTVA    + +Y WG
Sbjct:    4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWG-GGLG-TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-GGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT--------VPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKL---PMMMKTFHTDSSD-----------NVDTAKPQTR--NYEFEKRSVVYVMDINTLNL-----------------SPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGD-----LVDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT----INSVHEFTKVEAVMRHC--VNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EK + VG+GA+G   L R++ D +LVILKEI +  ++  ER  A NE +VL  L HPNI+ Y+++F ED  LMI MEYA  GTLA ++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+ H +   P++    +TD  +           NV  A P  R   +    R+   +  + +  +                 +P+RLP     + Q+  G    + +T    + TW   E   +G G+      V++ +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V +S   SHV+ V++E  ++ WG   NG+LGL + + +  PQ ++       +      D +M+++          +     G N      +   S +++P+    +  VH F  V++   +   +  + +G  H+  + E G+   FG N  GQLG    ++S +P +V  ++   IT    G  FT+A      +Y WG
Sbjct:    4 YEKTKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHSFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIRPLL--NLYTDIGNVKMRRIEKPLSNVQ-AGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLFSVYTWGSGISTPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITW---EAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMS--------TQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQ--GITMAACGDAFTLAIGAEGEVYTWG 643          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD-------------------SSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNL--------SPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL----VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPT-INSVHEFTKVEAVMRHCVNQ-----VSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +E+IR VG+GA+G   L  +K D  LVILK+I +  ++  ERQ A NE +VL  L+HPN++ Y+++F ED  LMI MEYA  GTLA+F+  +    LEE+ IL  F QI+ A+H++H H ILHRDLKT NI L K   ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++L+ SLL   P  R     I+   L +  +   HTD                   +S +  +     R     +  V   +     ++        SP+RLP     + Q+ +G      +T    +  W +   G  G G L    V+  +P+ VS   +     ++  +ACG+ F+    + GIIMT GSG +G LGHG+  D+ +P ++E+LL  ++V ++   SHV+ +S++  ++ WG    G+LGL +   +  PQ +        +      D++M+LT                G N      +   SL ++P     V E      +    ++Q     V +G  H+  +  SG    FG N  GQLG  S + S  PC V+ ++  K+  V  G  FTVA      +Y WG
Sbjct:    4 YERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGA-GGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSP--------GRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWG 644          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTL-AQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKG--QFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSD----NVDTAKPQTRNYE-------FEKRSVVYVMDINTLNLSPVRL---PSKIRIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFK--DVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNS-PIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +G+GA+G A LYR+ +DDSLV+ KE+++  LS  ER+ A+NE+ +L+ L H NI+AY++ F ++  L+IE+EY + G L  + L  ++K  EE+ ++   FQIVSA+  IH+  ILHRD+KT+NIFLTK  +IK+GD+G++K L++ +  A +++GTPYY+SPE+CQG  YN KSD+WA+GC+++E+  L +TF+ +N   L  KI++G    E     YS EL +++ S L+++P+ R + + +L    P++ K            N  T +P++             + S VYV        +P +L    S    +Q+C+G  H  V+T ++ ++TW     G+   GQLGHGD    ++P+ V  L  K++ +++CG+DF++   + G +   GS   G +G       +VL+P  +   L+  V  +S  ++HVVV++    +Y WG  + G+LGLDS   Y +PQ +   + +++       D T LLT++G +LA G N  NKLGLN  +  ++  ++  + P   S   FT  + +  + +  ++ GK HT  + E G+++ FG N  GQLG G+ K    I      +   ++ +V+ G  FT+A  D N ++ WG
Sbjct:   55 IRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDR--PLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGG--KSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTS---FTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGS--YSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTD--SSDNVDTAKPQTRNYE-------FEKRSVVYVMDINTLNLSPVRL---PSKIRIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLG--HGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGS-TKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +G GAYG A LYR+ +DDSLV+ KE+ +  LS  ER+ A+NE+ +LS L H NI+AY++ F +   L+IE+EY + G L   + +Q+  L +E+ +L   FQIVSA+  IH+  ILHRD+KT+NIFLTK  +IK+GD+G++K LS+ +  A + +GT YY+SPE+CQG  Y+ KSD+WA+GC+LYE+  L +TF+ +N   L  KI++G +     +  Y+ EL E++ + LE++P+ R + + IL   +    +    +  S  N    KP+T             + S VYV        +P +L       R +Q+C+G+ H  V+T ++ ++TW     GS   GQLGHGD    ++P+ V  L  KS+ +++CG+DF++   + G + + GS   G LG       +VL+P L++  L   V  +S  +SH++ ++    +Y WG  + G+LGLDS +   SPQ +  +  + + N     D + LLT TG +LA G N  NKLGLN     ++  ++  + P   S+   T  + +  + +  +S G+ HT  + E G+++ FG N  GQLG G   K+  I      +   ++ +V+ G  FT A    N ++ WG
Sbjct:   37 IRVLGHGAYGEATLYRRTEDDSLVVWKEVGLARLSEKERRDALNEIVILSLLQHDNIIAYYNHFLDSNTLLIELEYCNGGNLFDKIVHQKAQLFQEETVLWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKQLSSEYSMAETCVGTLYYMSPEICQGVKYSFKSDIWAVGCVLYELLTLTRTFDATNPLNLCVKIVQGNWAVGLDNTVYTQELIEVVHACLEQDPEKRPTADEILERPILSWRRRDMEEKVSMLNRSNKKPRTGTVTEAPIAVVTSRSSEVYVWGGG--KTTPQKLDVFKGGWRARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSL---TLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADNHIFAWG 657          

Query:  177 MSESLSVVIVSSKVRHSNTIHKNINTNTLFFQYRYDVGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKKLNSFFDLNRENECRIDFLNCNIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNHXXXXXXXXXXXXXKEIENLKKRELTSIYERKTFSAVCAIQ 3539
            MSESLSVVIVSSKVRHSNTIHKNINTNTLFFQYRYDVGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKKLNSFFDLNRENECRIDFLNCNIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVLLLEEKLKFQNHQILQNNLIINQLQKEIENLKKRELTSIYERKTFSAVCAIQ
Sbjct:    1 MSESLSVVIVSSKVRHSNTIHKNINTNTLFFQYRYDVGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKKLNSFFDLNRENECRIDFLNCNIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVLLLEEKLKFQNHQILQNNLIINQLQKEIENLKKRELTSIYERKTFSAVCAIQ 1121          

Query:  195 VVIVSSKVRHSNTIHKNINTNTLFFQYRYD-VGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKKLNS-FFDLNRENECRIDFLNCNIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEH----ESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFH---TDSSDNVDTA-KPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIR 2555
            ++IVSSKV++S+ +   +  N    QY+Y+    D ILG++  +LG+ K++++A++++ST   +++C  + K+       L H+ ++  FF  L++   D +  N  R+DFL CN     +   I   ++ ++ V   ISKD+ G+DI +E        P     + YF ++ L  +  QQ+++GFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDL+A+ERQLA+NEVKVL+ LDHPNI++Y+DSFEEDG LMIEMEYAD GTLAQFLS+QEKPLEEK+IL MF Q+V+AI +IHEH ILHRDLKT N+FLTKE ++K+GDFGISKM+ TT   AN+V+GTPYYISPEMC+GK YN+KSD+WALGCILYEM CL KTFEGSNLPALVNKI+KGQF PVKG+YS E K +I  +LEK P  R S   +++ K+P +M+ F    TD  D++ T+ +  T     + RSV+Y ++   + L PV LP+K+RI+++  G +H IV+T +R V+TWG    GQLGHGD     KPE+V +L  KS+ R  CG+ FS+F  +NGIIMTCG G +G LGHGD+    +PRLIE+LL++DV  ++    HVVVV  +  I+ WG   +G+LG  +      P  +   E ++V+  F   D TMLLT+ G +LA GNN  NKLGLN R GFLM MK++  +  +  V   T V A+  H V   S+G  H+ VL E G +  FG N+ GQLG G+TK    P +VK M    +++   G  +T      N  YFWG R
Sbjct:  138 LLIVSSKVKNSSLMQSALLPNVTIVQYKYENSTLDSILGLVAQSLGSKKVESIALIMHSTGRCIHLCGVEEKLVTKE-NILEHASIR-EFFTTLSTNHLDKSWVN-SRLDFLGCNTAQNVDGGIIANIIEDLVGVPVGISKDISGNDIPMERIAVDSETPVSCVGELYFRLDKLKKWG-QQSLSGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLNASERQLALNEVKVLAMLDHPNIISYYDSFEEDGTLMIEMEYADGGTLAQFLSSQEKPLEEKEILGMFQQMVAAIRHIHEHNILHRDLKTANVFLTKEGVVKMGDFGISKMM-TTAAKANTVLGTPYYISPEMCEGKAYNDKSDIWALGCILYEMACLQKTFEGSNLPALVNKIMKGQFAPVKGNYSPEFKAVIRDMLEKEPQYRPSAYELMYKKIPPLMERFLDPVTDIEDDLTTSTESSTMKLRKKTRSVLYYLETWDMKLHPVDLPAKVRIREVAVGADHVIVVTNERVVYTWGEGGKGQLGHGDQESLTKPEMVEALKGKSITRACCGDCFSVFASDNGIIMTCGDGSNGCLGHGDWYSNSRPRLIEALLSVDVSSVACGPHHVVVVGGDGEIFSWGKGSHGRLGHGNEEDCAQPMQVKITEPMMVREVFCGVDGTMLLTDVGSVLAFGNNEYNKLGLNNRQGFLMAMKNIFAKTEVEEVKAPTIVRALTNHRVINASLGPKHSAVLVEPGHVYTFGKNAEGQLGTGNTKQQNAPIKVKAMDGKVVSRARCGDMYTAVSTSDNEFYFWGTR 929          

Query:  195 VVIVSSKVRHSNTIHKNINTNTLFFQYRYD-VGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKK--LNSFFDLNRENE-------CRIDFLNCNIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEH-ESHPSKIAAKFYFSINNL--ISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDS-------SDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVK--TMKKHKITKVTSGSNFTVACVDF-NSLYFWGIRQTKKSDMRFLNGNESFK--NKSQVINERPIEH 2645
            ++++SS+ ++S TI  ++ +N    +Y Y+    DGIL      LG  K++++A V++S+  ++Y+CS+               L  +N  ++  +  F+    EN         R+DFL C+     E   I  E++ +L V   ++KDL  ++I ++      S    + YF    L  +S S  QT+ GFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDL+A+ERQ+A+NEVKVL+ LDHPNI+ Y+DSFEEDGVLMIEMEYAD GTLA+++  +E PL EK+IL MF QIV+AI +IHEH ILHRDLKT NIFLTKE +IK+GDFGISKM+++ + GAN+V+GTPYYISPEMC+GK YN+KSD+WALGCI+YEM CLH+TFEGSNLPALVNKI+ GQF PVKG+YS E K+LI  +L++ P  R S   +L+H+LP +M  +   +       S ++D +K          RSV+  +D   + L+P+ LP+KI+I+Q+  G  H +V+  +R V+TWG    GQLGHGDL+ R KPE+V +L  KS++R  CG+ FS+F  +NGI+MTCG G +G LGHGD+    +PRLIE LL++DV  IS    HVV V S+  ++ WG  K+G LGL     + SPQ +   E V ++      D TM LT+ G +LA GNN  NKLGLN R GFL  MK+L Q+  +      T V A+  H    +++G  HT+VL E GK+  FG N  GQLG G TK    P EVK  ++    +T +  G  FT   ++  N+L+FWG R   K D    N N+S +     +  +  PI H
Sbjct:  151 LLLLSSRAKNSGTIATSVRSNVHVIRYNYENSTLDGILKQAAEVLGGIKVESIACVMHSSGGSIYVCSD-------------RLLTSLNIIEQSSIRDFYSTLVENHLDRSFVNARLDFLACSAVQSVESGTILQEMESLLGVSVGMAKDLSAAEISMQRIGEDSSTTVGELYFREEKLQQLSGSSPQTLAGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLTASERQMALNEVKVLAMLDHPNIITYYDSFEEDGVLMIEMEYADGGTLAKYVGQRETPLSEKEILFMFQQIVAAIRHIHEHNILHRDLKTANIFLTKEGVIKVGDFGISKMMTSANHGANTVLGTPYYISPEMCEGKAYNDKSDIWALGCIMYEMACLHRTFEGSNLPALVNKIMNGQFAPVKGNYSHEFKDLIQDMLQREPQYRPSANELLYHRLPELMARYEEGATEWEDELSSSLDGSKQLASCKRRRTRSVLVYLDTCAMTLTPIELPAKIKIRQVAVGLEHMVVVAMERAVYTWGEGSKGQLGHGDLLGRSKPEMVEALKGKSIVRACCGDGFSVFVSDNGIVMTCGDGSNGCLGHGDWMSASRPRLIEPLLSVDVRAISCGPHHVVAVGSDGEVFAWGRGKHGCLGLGDEEDHFSPQEVQISEPVFIREVKCGVDGTMFLTDMGSVLACGNNENNKLGLNHRQGFLRAMKNLLQKVEVPGRKVPTVVRALTNHRAIDMAVGPHHTSVLVEPGKVYTFGRNLEGQLGTGHTKPRDAPMEVKDLSISDKTVTMLACGDMFTAVGINSENALFFWGTRYRPK-DKPEENNNQSAEGAGAGEEQDHAPIGH 978          

Query:  192 SVVIVSSKVRHSNTIHKNINTNTLFFQYRYDVGYDGILGILQNNLGANKIKNLAIVLYSTPFAVYIC-SNDGKVQQFSGEFLGHSLLQINFFKKLNSFFDLNRENECRIDFLNCNIFNMAEITEITAELKKILL--VECSISKDLWGSDIIIEH---ESHPSKIAAKFYFSINNL--ISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKL--PMMMKTFHTDSSDNVD---TAKPQTRNYEF--------------EKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVIL-HLKNPENNSKDK---ELICLTNCITFRDHSLLVQIETTAPPP--------------------RRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNEL 3089
            SV++++ K R  +++   +  NT      +D G  G+   +   L   K  N+A +  ST  +V IC   D ++  F+ E +       NFF  ++S F        R+DFL C+     E   +  EL+ +L   +E S+S++LWG D+II+    E   +      Y+  + L  ++ S  Q++ GFEKIR VGKGAYGTAVLYRKKDDDSLVILKEINMHDL+A ER L +NE+KVLS LDHPNI+ YFDSFEEDGVL+IEMEYAD GTLAQ+LS+  +PL EK  L  F QIVSAIH+ H HKILHRDLKT NIFLTK+ I+K+GDFGI+KM+ST+   A++V+GTPYY+SPEMC+GK YNEKSD+WALGC+LYE+ C  KTFEGSNLPALVNKI+KGQF PVKG+YS E KEL++ +L     ++  T   L +KL  P++ +    DSS + D   TA  +                    +KRSV+Y M++  L+L+P  LPSK+RI+ +C  + H I + ++R+V++WG N  GQLGH DL+ R KP LV +L  K + R  CG  FS+F  +NGI+MTCGSG  G LGHGD+  V +P+LIESLL++DV  I+    HVV  S E  ++ WG   +G+ GL      C+P  +  +E   ++  +   D +M LT+ G +LA+GNN  N+LGLN R GFLMTMK++  +  ++ V E T + A+ R+ V  +SMG  HT VL E   ++ FG NS GQLG G TK      EV+ +    +T V  G  FT+  V  + L  WG+R     D      +   +   + ++    +     A       +       S ANG     ++  + + P PI++L + + P  +S      E + L   +T RD SL+VQ+ETTAP P                        +K +P  +   S+   ++   ++         G++S+S+P       E E +PTW+K E 
Sbjct:    7 SVIVITEKFRAISSVEHAVLNNTQIVVAPHDRGLQGLTNAISAALKGRKANNIAFIFNSTLNSVQICLEEDQRLCLFNLESVKTCFELRNFFLYVSSAFLTQELGSKRVDFLACSNAGTQEAQALLQELRSLLGSDIEVSLSRELWGLDVIIQRNIDERGRNYRVGDVYYKPDKLRTLTASSGQSLAGFEKIRIVGKGAYGTAVLYRKKDDDSLVILKEINMHDLTAQERLLCLNEIKVLSMLDHPNIIGYFDSFEEDGVLLIEMEYADGGTLAQYLSDCREPLSEKDALYYFQQIVSAIHHFHSHKILHRDLKTANIFLTKDNIVKVGDFGIAKMMSTSRHAASTVLGTPYYLSPEMCEGKEYNEKSDIWALGCVLYEIACQQKTFEGSNLPALVNKIMKGQFAPVKGNYSQEFKELVAKMLLNKEPEKRPTAADLLYKLLPPLIRRVNEADSSTDADEDGTASARGGGGGGGSGGQMGSGSGSRPDKRSVLYAMNLANLSLTPYNLPSKLRIRSVCCSDTHAIAVGSERSVYSWGENASGQLGHEDLIARSKPTLVDALRGKGISRATCGLAFSVFTSDNGIVMTCGSGSHGCLGHGDWVSVARPKLIESLLSVDVAAIACGPQHVVAASKEGRVFAWGRGADGRTGLRDETDRCAPTPVPIQEPQRIRAVYAGTDGSMFLTDAGSVLATGNNRHNRLGLNQRQGFLMTMKNMFNKLDVDGVKEPTPLRALARYKVIYISMGPEHTAVLVEPNHVVTFGRNSEGQLGLGITKAQGGIVEVQGLDGKAVTGVVCGPRFTLCQVADSELLLWGLR-VPLPDRHPSQQHRQRRRSFESVDSDDSDDSGDGAGGGGGGSDGGGGGGGSRANGR--RGAHPELHLTPVPILMLNNNQKPSPSSATATAVEQVSLGAVLTQRD-SLMVQVETTAPAPSHRRHQQQPQRRERSISSSSSSAAAKRLPSAQAPPSAQSSSLSRRQLNGS--GGAAGDSSDSAP-------EPEPLPTWVKREF 1010          

Query:  195 VVIVSSKVRHSNTIHKNINTNTLFFQYRYDVG-YDGILGILQNNLGANKIKNLAIVLYSTPFAVYICSNDGKVQQFSGEFLGHSLLQINFFKKLNSFFDLNRENECRIDFLNC-NIFNMAEITEITAELKKILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSI--QQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMM-KTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVR-LPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQT 2561
            +V+VSSK+R+ ++I   +        Y  D    + I   + ++    K+K++A +L  +  A+++   + K+    G       +Q  F   +N +   + +   R+DFL   ++ N      + AEL+ +  V CS+S+DL G +I    E +        YF ++ L ++S   QQ++ GFEKIRTVGKGAYGTAVLY+KKDD+SLVILKEINMHDL+A ERQLA+NEV VL+ LDHPNIV+Y+DSFEEDGVLMIE+EYADNGTLAQ+LS Q+KP+EEK IL MF QIV+AI +IH H +LHRDLKT NIFLTKE ++K+GDFGISKML +T+ GA +V+GTPYYISPEMC+GK Y+ KSD+WALGCILYEM C  KTFEGSNLPA+VNKI+K QF P+KG+Y++  K+LI  +L+ NP++R     I++H+LP ++ K    +S   VD + P+  N + + RSV+Y  + +T  L+ +  LP +++IK +  G  H IV TT+R VFTWG   +G+LGHGDL +R  PELV  L  KS+  + CG  FS+FG +NG+++TCG G  G LGHGD+    KPRLIESLL+ DVV +++   HVVV+  E  +  WG   +GQLGL S    C+P ++   E V+      S D TML+++ GG+ A GNN  NKLGLN R GFLM MK++  +  ++  +  T V A+ RH V  VSMG  HT V+ E G +I FG NS GQLGN +TK S  P EVKT+    +T V  G ++T+A    + L++WG+R T
Sbjct:  143 LVVVSSKIRNVSSIRHALMPGVALVPYSCDAQTLNHIEAQIAHHCRGEKVKSIAFLLSCSGPALHLLVKEDKMLNKDGSM--DESVQKFFIDVVNKYMSPDDDFR-RLDFLGWYSLQNNETAPPVVAELQNLTGVTCSVSQDLSGQNISKRSEDNLRIGIGDMYFRLDKLRNWSGRHQQSLAGFEKIRTVGKGAYGTAVLYKKKDDESLVILKEINMHDLNAFERQLALNEVSVLALLDHPNIVSYYDSFEEDGVLMIEIEYADNGTLAQYLSKQDKPMEEKDILLMFQQIVAAIRHIHSHNVLHRDLKTDNIFLTKEGVVKVGDFGISKMLGSTNIGAQTVLGTPYYISPEMCEGKQYSFKSDIWALGCILYEMACFQKTFEGSNLPAVVNKIMKVQFSPIKGNYTEAFKDLIKDMLKMNPEERPEANHIMYHRLPALLNKLDKKESETEVDVSYPENINRKSKIRSVLYYYEFSTTMLTCINGLPPRMKIKHMAVGPEHVIVTTTERQVFTWGHGGYGELGHGDLKNRLSPELVEGLQGKSVATVCCGLGFSVFGSDNGLVLTCGDGSQGCLGHGDWCSTNKPRLIESLLSFDVVAMASGMCHVVVIGREGQVMSWGDGSHGQLGLGSEESQCTPTIVQIAESVIFTGVQCSADGTMLISDVGGVFACGNNENNKLGLNNRQGFLMAMKNIFTKTEVDGTNIPTPVRALARHRVISVSMGLYHTAVIVEPGHVITFGKNSEGQLGNQNTKPSGNPVEVKTLGDKIVTHVQCGDHYTIASTRCHELFYWGLRYT 934          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSD--NVD----TAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVN-----QVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EKI+ VG+GA+G   L R++ D +LVILKEI +  ++  ER  A NE +VL  L+HPNI+ Y+++F ED  LMI MEYA  GTLA ++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+   LP+ ++      +D  NV     ++   T+       S VY         +P+RLP     + Q+  G    + +T    + TW +   G  G   L   V++ +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V +S   SHV+ V++E  ++ WG   NG+LGL + + + +PQ +        +      D +M+++    +LA G+N  NKLG       L  +    + P+   V E    + V    +N      + +G  H+  + E G+   FG N  GQLG  S ++S +P  V  ++   +T    G  FT+A      +Y WG
Sbjct:    4 YEKIKVVGRGAFGIVHLCRRRVDGALVILKEIPVEQMTRDERLAAQNECQVLKLLNHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILTMLNLDPSKRPQLNEIM--ALPICIRPLLNLYTDIGNVKMRGLSSLSSTKMMHSLPLSSVYTWGSGI--STPLRLPMLNTEVLQVSLGRTQKMGVTKSGRLITWEAPSVGS-GEPSLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCMTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLGTQDTHNAPQQVDVPAEFEAQRVLCGVDCSMIISTQHQILACGSNRFNKLG-------LDKIADTEEPPSCCQVEEVQTFQPVQSAPLNVEKIVYIDIGTAHSAAVTEKGQCFTFGSNQHGQLGCSSRRSSRVPYPVPGLQ--GVTTAACGDAFTLAIGTEGEVYTWG 615          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTF--------------------------HTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNL------SPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVN-----QVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EKI+ VG+GA+G   L R++ D +LVILKEI +  ++  ER  A NE +VL  L+HPNI+ Y+++F ED  LMI MEYA  GTLA ++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+   LP+ ++                            H  +   V   + +          +++ + ++++        +P+RLP     + Q+  G    + +T    + TW +   G  G   L   V++ +P+ +S   +     ++  ++CG+ F+    + GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V +S   SHV+ V++E  ++ WG   NG+LGL + + + +PQ +        +      D +M+++    +LA G+N  NKLG       L  +    + P+   V E    + V    +N      + +G  H+  + E G+   FG N  GQLG  S ++S +P  V  ++   +T    G  FT+A      +Y WG
Sbjct:    4 YEKIKVVGRGAFGIVHLCRRRVDGALVILKEIPVEQMTRDERLAAQNECQVLKLLNHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILTMLNLDPSKRPQLNEIM--ALPICIRPLLNLYTDIGNVKMRRIEKQLSSVQTGPHGRAGGRVTGTRTRGGLSSLSSTKMMHSLPLSSVYTWGSGISTPLRLPMLNTEVLQVSLGRTQKMGVTKSGRLITWEAPSVGS-GEPSLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCMTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLGTQDTHNAPQQVDVPAEFEAQRVLCGVDCSMIISTQHQILACGSNRFNKLG-------LDKIADTEEPPSCCQVEEVQTFQPVQSAPLNVEKIVYIDIGTAHSAAVTEKGQCFTFGSNQHGQLGCSSRRSSRVPYPVPGLQ--GVTTAACGDAFTLAIGTEGEVYTWG 643          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLA-QFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQF--EPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTA--KPQTRNYEFEKRSVVYVMDINTLNLSPVRL-PSKIRI-------KQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGD--FKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMT-MKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHK-------------ITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +GKGA+G A LYR+ +D+SLV+ KEI++++LS  +R+  MNE+ +LS L H NI+AYF+ F +   L+IE+EY + G L  + +  + K   E+ ++   +QI SA+ +IH+  +LHRD+KT+NIFLTK  +IK+GD+G++K L + +  A + +GTPYY+SPE+CQG  YN KSD+WA+GC+LYE+  L +TF+ +N   L  KI++G +  E     YS EL +++ + L+++P+ R +++ IL   +   ++    D    +++A  KP+         ++V             +  P K+ +       +Q+CSGE H  V+T ++ ++TW     G+   GQLGHGD    ++P  V  L  K++ ++ACG DF+    +   +   GS   G +G  +    +VL+P L+E      V  +S  ++HVVV++    IY WG  ++G+LGLD  + + SP ++   +   + + +   D T  LTE+G +LA GNN+ NKLGLN  +  +    +  SQ+  I      T V+ + R  +  ++ GK HT  + E G+++ FG N  GQLG            VK  K+H+             ++KV+ G  FT+A  + N ++ WG
Sbjct:   42 IRVLGKGAFGEATLYRRTEDNSLVVWKEIDLNNLSDKKRRDVMNEISILSILQHHNIIAYFNHFMDKNTLLIELEYCNGGNLYDKIIQQKGKLFTEEIVIWYLYQIASAVAHIHKAGVLHRDIKTLNIFLTKTNLIKLGDYGLAKKLDSEYSMAETCVGTPYYMSPELCQGVKYNFKSDIWAMGCVLYELLTLTRTFDATNPLNLCVKIVQGNWTMEVNSDVYSSELIKIVYACLDQDPEKRPTSDQILDQPIISRVRQELEDRVAVLNSAIRKPKLSTVSETPVAIVTTRSREVYFWGGGKFTPQKLDMFKGGNSAQQVCSGETHFAVVTVEKELYTWASVQGGAKMVGQLGHGDQASYRQPRKVERLQGKAIRQVACGADFTACVTDEDQMYMFGSDYYGCIGVENEMGMEVLEPVLLEFFEERPVRQVSCGDNHVVVLTHSGDIYSWGCGEHGRLGLDCEDDFASPMLVEVPKGASIDSVYCGSDGTFFLTESGKVLACGNNDLNKLGLNQGITGIKNHFREGSQE--IPYTTTLTLVKQLARFKIQIIAPGKTHTAAIDERGRLMTFGCNKYGQLG------------VKDFKRHQGVQILLGPFGGKVVSKVSCGDGFTIAATEDNQIFAWG 664          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            ++ +EK++ +G+G++G A+L R K+D    ++KEI +  +S  ERQ +  EV VL+ + HPNIV Y +SFEE G L I M+Y + G L + ++NQ+  L  E++IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  I++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYEM  L   FE  N+  LV KI++G + PV   YS +L+ L+  L ++NP +R S   IL
Sbjct:    1 MDKYEKVKKIGEGSFGKAILVRSKEDGHQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEEGGCLYIVMDYCEGGDLFKKINNQKGVLFTEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSMHYSQDLRSLLGLLFKRNPRERPSVCTIL 253          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            ++ +EK++ +G+G++G A+L R K+D    ++KEI +  +S  ERQ +  EV VL+ + HPNIV Y +SFEE G L I M+Y + G L + ++NQ+  L  E++IL+ F QI  A+ ++H+ KILHRD+K+ NIFLTK+  I++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYEM  L   FE  N+  LV KI++G + PV   YS +L+ L+  L ++NP +R S   IL
Sbjct:    1 MDKYEKVKKIGEGSFGKAILVRSKEDGHQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEEGGCLYIVMDYCEGGDLFKKINNQKGVLFTEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSMHYSQDLRSLLGLLFKRNPRERPSVCTIL 253          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFE-PVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNL----SPVRLPSKI-------RIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLG-HGDFK-DVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGS-TKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDF-NSLYFWG 2549
            +R +G+GA+G A LYR+ +D+SLV+ KEI++  LS  ER+ + NE+ +LS L+H NI++Y++ F +  VL+IE+EY + GTL + +  Q      EK I+  F+Q+VSA+  IH  KILHRD+KT+NIFLTK ++IK+GDFGISK+L +  + A S +GTPYY+SPE+ +G  YN KSD+WA+GC+LYE+  L +TF+ +N   L  +I+ G+ +  +   YS E+KE++   L+++ + R + E +L       +KT   +   NV       R    +    V V+   + ++       R P  +          ++C+   H   +T ++ ++TW     G+   GQLGH D    ++P+ V  L   ++ ++ACG++F++   E G + + GS   G +G +G+   +VL+P  ++      V  IS  + HV+ ++    +Y WG  + G+LGL++      P+ +       +       D T  LT  G +LA GNN  NKLGLN     L   ++      I  +   T V+ +  + +  +S GK H+ V+   G+++ FG N  GQLG G   K+  I      +    IT V+ G  FT+A  +  N +Y WG
Sbjct:   39 VRVLGRGAFGEAALYRRNEDNSLVVWKEIDLTRLSDKERRDSQNEIDILSLLEHANIISYYNHFLDGNVLLIELEYCNGGTLYEKIIKQHGAFFPEKDIVWYFYQLVSAVEQIHNFKILHRDIKTLNIFLTKSDLIKVGDFGISKILDSRSQMAESYVGTPYYMSPELIRGDKYNTKSDIWAMGCVLYELLTLTRTFDATNPLKLCYEIIHGKKQVEIDDQYSKEIKEVVQKCLQQDAEQRPTAEDLLELS---PIKTRRREMEKNVWRLNEPARRIRSDNAEAVPVVTARSSDVYYWGGGKRTPQMLDQFRGGYSALRVCASNTHFAAVTVEKELYTWANVQGGTKMVGQLGHKDKASYRQPKRVDKLLGLAVRQVACGDEFTVCLTEQGEVFSFGSDYYGCMGCNGELGVEVLEPMPVQFFNINPVTQISCGDCHVMALTRSGAVYAWGCGEYGRLGLETDATEFYPKRVPLSNRWKITEVCCGTDGTFFLTAQGKVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMP-TLVKQLSIYKIRSISGGKTHSAVIDVCGRLLTFGHNKHGQLGTGDFKKHLGIVLHKGPLVGKLITMVSCGDGFTIAATEADNHIYAWG 659          

Query: 1596 MDINTLNLSPVRLP--SKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLG---------------HGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVL-----KPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGL 2060
            ++ +     P R+P  ++ +I ++C G + T  LT    V   G+NEF +LG                 +++ +  P LV  L+   +  I+ G   S      G ++T G    G LG GDFK  L     K  L+  L+T+ V C       +    +++ IY WG+  NG+LG+
Sbjct:  495 LETDATEFYPKRVPLSNRWKITEVCCGTDGTFFLTAQGKVLACGNNEFNKLGLNQCTSGLRNRETSVFHEVIMKLMPTLVKQLSIYKIRSISGGKTHSAVIDVCGRLLTFGHNKHGQLGTGDFKKHLGIVLHKGPLVGKLITM-VSC--GDGFTIAATEADNHIYAWGNTDNGRLGV 668          

Query:  975 NGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM-MMKTFHTD---------------SSDNVDTAKPQT--------------RNYEFEKRSVVYVMDINTLNLSPVRLP-SKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDL---VDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXX--------XXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
             GTLA+++  +   L +E  IL  F QI  A+H++H + ILHRDLKT NI L K + ++KIGDFGISK+LS+  + A +V+GTP YISPE+C+GK YN+KSD+WALGCILYE+  L + FE  NLPALV KI+ G F PV   YS EL++L+ SLL  +P  R     +L H + M  M   + D                S +V  ++P                        S VY+    T  L+PV+L      + Q+  G      +T    +  W ++  G +G   L   V   +P+LVS   +     ++  ++CG+ F+    + GI+MT GSG SG LGHG + DV +P+++E+LL  ++  +S   SHV+ VS+E  ++ WG   NG+LGL +  L+  PQ +          A    D +M+ +    L    N           +  G +A      T +SL   P  +S  +  +V          V++G  H+  + ++G    FG N  GQLG G+  +S  P  V  +   K+ +VT G  FTVA  +   ++ WG
Sbjct:    1 GGTLAEYIQKRGGSLLDEDTILHFFVQIALALHHVHSNHILHRDLKTHNILLDKRQTVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCILYELASLKRAFEAENLPALVLKIMSGNFAPVSDRYSGELRQLVVSLLNLDPSKRPQLSEVLSHPVCMSAMIRLYMDIGRVPARFVSGEPELISPSVSASRPTAPVSGDGAPAGSAGRAGAAPPPLSSVYMWGSGT--LAPVKLAMPNTEVLQVAVGRTQRAGVTRSGRLIVWEASP-GTVGDAALPGSVGSVQPQLVSRFLEGQSGVTIQHVSCGDLFTACLTDRGILMTYGSGSSGCLGHGSYSDVAQPKIVEALLGYEITQMSCGMSHVLAVSNEQEVFAWGRGDNGRLGLGNQELHLCPQPVAVPPPYEPCTAHCGIDCSMVTSSGKLLACGSNRRYNKLGLDKISHDGDDAACPAEQTEESLVLSPVQSSPLDGARVV--------HVALGTAHSAAVTDTGTCYTFGSNQHGQLGGGARTSSRAPQPVDGLGGVKVVQVTCGDAFTVAVAEGGQVFTWG 561          

Query: 1608 TLNLSPVRLPS--KIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGD 1910
            +L LSPV+       R+  +  G  H+  +T   T +T+GSN+ GQLG G     + P+ V  L    ++++ CG+ F++   E G + T G    G LG  D
Sbjct:  470 SLVLSPVQSSPLDGARVVHVALGTAHSAAVTDTGTCYTFGSNQHGQLGGGARTSSRAPQPVDGLGGVKVVQVTCGDAFTVAVAEGGQVFTWGKAARGRLGRTD 572          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPM 1496
            +  +  +G+G++G A+L + K D  L ++KEIN+  +S  ER  A  EV VL+ + HPNIV+Y +SFEE G L I M+Y + G L + ++ Q+  L  E +IL+   Q+  A+ ++H+ KILHRD+K+ NIFLTK  I+++GDFGI+++L++T E A + IGTPYY+SPE+C+ K YN KSD+WALGC+LYEM  L   FE  N+  LV KI++G F PV   YS EL+  +S LL ++P  R    V+L   L M
Sbjct:    4 YTMVSQIGEGSFGKAMLVKSKADGHLYVIKEINISRMSPKERDEARKEVCVLANMRHPNIVSYKESFEERGNLYIVMDYCEGGDLFKRINAQKGVLFSEDQILDWLVQLCLALKHVHDRKILHRDIKSQNIFLTKAGIVQLGDFGIARVLNSTTELARTCIGTPYYLSPEICENKPYNHKSDMWALGCVLYEMCTLRHAFEAGNMKNLVLKIIRGSFPPVSAHYSSELRSTLSGLLRRDPRARPPVAVLLSRPLLM 259          

Query: 1017 LEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNL-----PALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            + +  +++ F Q+  A+ YIH  KILHRD+KT N+FLTK   +K+GDFGISK +  T + A + +GTPYY+SPEMCQ   Y+ KSDVWALGC+LYE+  L   FE SN+      +L  KI++G+ +P+  SYS +++ L++ LL ++P+DR S   +L
Sbjct:    5 ITKTNVMQWFVQVCMAVQYIHSVKILHRDIKTSNVFLTKAGTVKVGDFGISKAMEGTLDMAVTCVGTPYYLSPEMCQDLPYSSKSDVWALGCLLYELCALRPAFEASNIIRLTRRSLFYKIMRGEPDPLDESYSRDVRALVALLLSRSPEDRPSASAVL 163          

Query:  807 LVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSF--EEDGVLMIEMEYADNGTLAQFLSNQEKP---LEEKKILEMFFQIVSAIHYIHEHK-----ILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSD 1406
            +++ K ++   +S  E+Q+ ++EV +L +L HPNIV YFD      +  L I MEY + G LA  +S   +    LEE+ +L +  Q+V A+   H        +LHRDLK  N+FL     +K+GDFG++++L      A + +GTPYY+SPE      YNEKSD+W+LGC+LYE+  L   F   N   L  KI +G+F  +   YSD
Sbjct:    2 VLVWKVLDYGTMSEPEKQMLVSEVNLLRELKHPNIVRYFDRIIDRSNTTLYIVMEYCECGDLASLISRCRRDRRFLEEEFVLRVLAQLVLALRECHRRTAGGRTVLHRDLKPANVFLDARHNVKLGDFGLARILQHDTSFAKTFVGTPYYMSPEQFSRMSYNEKSDIWSLGCLLYELCALVPPFTAMNQKQLAEKIKEGKFRRIPYRYSD 211          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYF--DSFEEDGVLMIEMEYADNGTLAQFLSN---QEKPLEEKKILEMFFQIVSAIHYIH---------------------EHKILHRDLKTVNIFLTKEE---------------------------------------IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYS 1403
            ++ +  +G+G++G+           L++ K+I    +++ ERQ  + E  +LSQL H NIV ++  D  E+  VL + MEY   G L+Q + +   + K + EK +  +  Q+++A++  H                     ++ ++HRDLK  NIFL+ ++                                       ++K+GDFG++K L T+ + A + +GTPYY+SPE+   + Y+  SD+W+LGC+++EM  LH  F+  N   L  KI  G+ + V   YS
Sbjct:   25 YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYS 313          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAM-NEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLY-NEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQF 1379
            I  ++ ++T+G+G++G   L         V LK IN   L+ ++ Q  +  E+  L  L HP+I+  +D  +    +++ +EYA N  L  ++  ++K + E++    F QI+SA+ Y H HKI+HRDLK  N+ L +   +KI DFG+S ++ T      +  G+P Y +PE+  GKLY   + DVW+ G ILY M C    F+  ++P L   I  G +
Sbjct:   52 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGN-ELFDYIVQRDK-MSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIM-TDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVY 269          

Query:  741 IRTVGK--------GAYGTAVLYRKKDDD-SLVILKEINMHDL-SATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKL--YNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKI 1364
            I+T GK        G  G A  ++ KDD   +   K +    + S   R+  ++E+++   + HPNIV + D FE+D  + I +E   NG+L + L  + K L E ++     QI  AI Y+H  +++HRDLK  NIF      +KIGDFG++ +L+   E   ++ GTP YI+PE+  GK   ++ + D+W+LG +LY +      F+  ++  +  +I
Sbjct:   75 IKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELL-KRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERI 293          

Query:  750 VGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQE-KPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEM--CQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLST 1466
            +G+G +G       +    +V +K +N+   S  + +L   E+  L++L  P I  Y  +  ED  + I MEY   G+ +  L       L E+K+  +  ++   + Y+HE + +HRD+K  NI L +E ++K+GDFG+S  + +T +  ++ +GTPY+++PE+  C+   YNEK+D+W+LG   YE+          +   ++  + K +   ++G +SD  K+ ++  L K P DR S 
Sbjct:   24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEH-SDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLK-RDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSA 263          

Query:  630 IIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATER-QLAMNEVKVLSQLDH-PNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEK--PLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEG-----------ANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQF 1379
            + IEH+S   K  AK        I   I++ I  F+    +G GAY T +L    D       K +N   L   ++ +    E   L +L++ P++V  F +F+++  L   +EYA NG    FLS  +K   L+E        QI+ AI Y+H + I+HRD+K  NI L  E  IK+ DFG +K+L+ T+             + S +GT  Y+SPE+      + + D+WA GCIL++M      F+ +N      K++K Q+
Sbjct:  148 VKIEHDSSSQKPIAKESSKAQKNI---IKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNG---DFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQY 406          

Query:  690 NNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEG-ANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRS--VVYVMDINTLNL----SPVRLPSKI-------RIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKD--VLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVK-TMKKHKITKVTSGSNFTV 2513
             ++++  IQQ +  +  +RT+G+GA+G AVLYRK +D+ LV+ KE+N+   S  ER  A+ E+ +LS L+H NIV YF+ F +   L IEMEY + GTL   +  Q +   E+ ++  FFQI +A+ +IHE+ I+HRD+KT+NIFLTK  ++K+GDFGISK+L +  EG A+S++GTPYY+SPE+ QGK YN+KSD+WA+GC+LYE+  L + F+ SN   LV+ I+KG +E +   Y++E+  L++ LL +NPDDR S + +L  ++P ++ T   +    V      TR       S   V V+   T  +    +  + P K+          Q+ +G +H  ++T ++ +FTW     G    GQLGHGD+   + P+ V +L    + ++ACG++F+    ++G + T GS   G +G  +  D  VL P  +       V  IS  + HVVV+ +   IY WG  ++G+LGL S + +  PQ I       VK  +   ++T LLT TG +LA GNN+ N+LGL+     L +++  S +  + S +    V+++ R+ +  V+ GK H+  +   G+++  G N  GQLG    ++ P PC+VK  +   ++ +   G  FTV
Sbjct:    5 GDILNAEIQQEM--YIPVRTLGRGAFGEAVLYRKIEDNMLVVWKEVNLSRASDRERADALKEIDILSLLNHTNIVTYFNHFIDGTSLFIEMEYCNGGTLHDKICVQNELFPEEVVIWYFFQICAAVGHIHENGIVHRDIKTMNIFLTKSGLVKLGDFGISKILDS--EGMADSIVGTPYYMSPEIVQGKKYNQKSDMWAVGCVLYEVLTLKRVFDASNPLRLVSDIVKGHYEEIDERYTEEMNSLVNKLLSQNPDDRPSVQELL--EMP-ILATLGKEMEKKVWQLNSSTRRARLVTHSSETVPVITSKTCEVYFWGAGKQTPQKVDTFVLGNTATQVAAGHSHFAIVTVEKEMFTWANAHGGKGMSGQLGHGDVACYRNPKRVDALFGIPIKKVACGDEFTACITDDGALYTFGSDYFGCIGCSNELDEEVLLPHKVTFFNDKPVEDISCGDCHVVVMCANKAIYSWGCGEHGRLGLGSEDDFAFPQKIPLPTSCKVKRIYCGPESTFLLTVTGRVLACGNNDENQLGLDT----LHSLRKRSIKGHVPSANSPKLVQSLNRYTIAIVAPGKTHSAFVDVYGRLVTVGSNKYGQLGVNDYQHHPSPCQVKGELVSKQVVEAACGEEFTV 623          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQE-KPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKE-EIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFH---TDSSDNVDTAKPQTRN-----YE----------------------FEKRSVVYVMDINTLNLSPVRLPS-KIRIKQICSGENHTIVLTTDRTVFTW-GSNEFGQLGHGDLVDRK--KPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EK+R VG+GAYGT  L R+  D+ LVI+K+I + +++  ERQ A+NEVKVLS   HPNI+ Y+DSF ++  LMI MEYA  GT+  +L  +  K ++E +IL +F QI+ A+ ++H+ +ILHRDLKT NI L K+ +++KIGDFGISK+LS+  + AN+VIG+P YISPE+C+GK YN+KSDVW+LGC+LYE+T L + FE SNLPALV KI++G F P+   YS+EL++LI  +L  +P  R   + I+    P+++       TD      T  P+T       YE                       E + +VY         +P+ LP     + Q+  G      +T +  +  W GS   G +  G   ++    P  +   +  ++ +++CG+ F+    + GI+MT GSG  G LGHG    V + +++E LL  +V  IS  +SH++ V+++  ++ WG   NG+LG  S   Y SP+ I+  E +  ++     D +  +T    LLA G+N  NKL L+   G +  +  L Q     SV +F  V        + V+MG  HT VL ++GK+ +FG NS GQLG      S  P  V+++  + ++ V  G  F+VA    + ++ WG
Sbjct:    4 YEKVRIVGRGAYGTVYLCRRLVDNFLVIIKQIPVEEMTKEERQSALNEVKVLSMFQHPNIIRYYDSFVQEKALMIVMEYAQGGTIYDYLQQRGGKLMDEDEILRLFVQILLALRHVHKGQILHRDLKTQNILLNKKRKVVKIGDFGISKILSSKSK-ANTVIGSPCYISPELCEGKPYNQKSDVWSLGCVLYELTTLKRAFEASNLPALVLKIMRGYFSPIPERYSEELRKLILDMLVLDPTKRPGIKEIMAQ--PVIVNALFDLPTDVGRVPCTRFPRTGAGIAGMYEESSASTILEGLPENLGVFAMKPQEPQHMVYHWGGGITYPNPLPLPQHDSGVVQVSCGRTLMTGVTANGRMILWEGSKSSGLMSSGGKNEKTVWVPRFLEGQSGITITKVSCGDLFTACLTDRGILMTFGSGTYGCLGHGTTNYVSQAKIVEDLLGFEVEDISCGSSHIMAVTADHEVFAWGRGDNGRLGTGSQQEYWSPKAISLPEGMRARSVHCGVDCSFAITLENKLLACGSNRCNKLALDNEDGPVEEVAVLRQV----SVPDFNSVGT------SSVAMGTSHTLVLLQNGKLYSFGSNSFGQLGYVREGVSRFPQLVESL--NDVSYVACGDTFSVAVSSDSEVFVWG 630          

Query: 1587 VYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVV 2000
            V V D N++  S V +           G +HT+VL  +  ++++GSN FGQLG+      + P+LV SL   S +  ACG+ FS+    +  +   G G  G LG+   +DV +P  +     + V+ +S +NS  ++
Sbjct:  547 VSVPDFNSVGTSSVAM-----------GTSHTLVLLQNGKLYSFGSNSFGQLGYVREGVSRFPQLVESLNDVSYV--ACGDTFSVAVSSDSEVFVWGKGARGRLGNKADEDVREPVCLSLPAAVQVLSVSCSNSGTLL 671          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILH 1481
            +N ++KI  +GKG +G+A L   +    L  LKE+N   + + +R LA+NEVK+LS L H NIV Y D+FEE G   I MEYA+ G L   +    +P   ++IL    Q++ A+ +IH   ILHRDLKT NIFLTK++++KIGDFGI+++L +T + A + +GTPYY+SPE+CQ + YN KSD+WALGC+LYE+T     F   NL  LV KIL G + P+   Y   L++L++ +L+ NP DR S + +++
Sbjct:    1 MNRYQKIDIIGKGTFGSAWLVESRQSKRLYALKELNATAMPSEDRHLALNEVKILSTLKHRNIVRYRDAFEETGRFYIVMEYAEGGDLHTKIKQAVEPFSSERILNWLAQLLLALKHIHGQNILHRDLKTQNIFLTKDDVVKIGDFGIARILDSTCDHARTTVGTPYYLSPEICQRQPYNNKSDIWALGCVLYELTTRTHPFTADNLTNLVVKILHGNYPPIPRFYGPLLEDLVAVMLKINPADRPSAKQLIY 253          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEK-PLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            + +++ +G+G++G A+L +K++D    ++KEIN+  +   ER+ +  EVKVLSQL HPNIV+Y +SFEE G L I M+Y D G L + ++ Q      E ++++ F QI   + ++H+ KILHRD+K+ NIFLT+  IIK+GDFGI+++L +T E A + IGTPYY+SPE+ + + YN KSD+W+LGC+LYEM  L   FE  N+  LV KI++G + P+   YS +++ L++ LL++NP DR S   +L
Sbjct:    4 YVRVKKIGEGSFGKALLVKKRNDGKHYVIKEINICRMKPREREESRKEVKVLSQLKHPNIVSYQESFEESGNLYIVMDYCDGGDLYKKINGQRGIAFSEDQVMDWFVQICLGLKHVHDRKILHRDIKSQNIFLTRHGIIKMGDFGIARVLHSTVELARTCIGTPYYLSPEIVENRPYNNKSDIWSLGCVLYEMLTLKHAFEAGNMKNLVLKIIRGSYPPIPLRYSADIRMLVAQLLKRNPHDRPSVNTVL 253          

Query:  744 RTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEED-GVLMIEMEYADNGTLAQFLSNQEK-PLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHH 1484
            + +GKG+YG   L + K D    +LK++++   S  ER+ A  E K+LSQL HPNIV+Y +SF++D G L I M + + G L   L  Q+  PL+E +I+E F QI  A+ Y+HE  ILHRDLKT NIFLTK +IIK+GD GI+++L ++ + A ++IGTPYY+SPE+   K YN KSDVWALGC LYEM  L   F   ++ +LV KILKG+  P+   YS +L  +I S+L+++PD R S   +L H
Sbjct:   10 KCIGKGSYGEVFLSKHKKDKKQYVLKKVDLQKASVRERKAAELEAKLLSQLRHPNIVSYRESFQDDTGFLYIAMNFCEGGDLYSRLKAQKGIPLDENQIVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKSKIIKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSNKPYNHKSDVWALGCCLYEMCTLRHAFNAKDMSSLVYKILKGKTPPLPKQYSTDLCSIIKSMLDQDPDKRPSASRLLRH 258          

Query:  732 FEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMK---TFHTDSSD-----------------------NVDTAKPQTRNYEFEKRSV-------VYVMDINTLNLSPVRLP-SKIRIKQICSGENHTIVLTTDRTVFTWGSNEF--GQLGHGDLVDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHC--VNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            +EKI+ VG+GA+G   L R++ D + VILKEI +  +S  ER  A NE +VL  L+HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+   LP+  +     +TD  +                        V T++ +  ++ F    V       VY         +P RLP     + Q+  G    + +T    + TW +     G+LG   +V+  +   +S   +     ++  ++CG+ F+    E GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V ++   SHVV V++E  ++ WG   NG+LGL + + + SPQ +        + A    D +M+++    ++A G+N  NKLGL+     +   +  SQ   +   H FT V++V  +   +  V +G  H+  + E G+   FG N  GQ+G  S ++  +P  V  ++   IT V  G  FT+A      +Y WG
Sbjct:    4 YEKIKVVGRGAFGIVHLCRRRSDGAFVILKEIPVEQMSRDERLAAQNECQVLKLLNHPNIIEYYENFLEDKALMIAMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIM--ALPICTRPLLNLYTDVGNVKMRRIEKPLSAVQLGLPGRPGGRVSTSRLREGSFGFGSGQVHSLPLSSVYTWGSGI--TTPFRLPMPNTEVLQVSLGRTQKMGVTKSGRLITWEAPSVGAGELGPPGVVEHMQLLFISRFLEGQSGVTIKSVSCGDLFTTCMTERGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVACGASHVVAVTNEREVFAWGRGDNGRLGLGTQDTHNSPQQVCLPVGFEAQRAVCGVDCSMIISSQSSIMACGSNRFNKLGLDR----ITAGEEPSQVNQVEEAHSFTPVQSVPLNTDKIVSVDIGTSHSAAVTEGGQCFTFGSNQHGQMGCSSRRSGRVPYLVLGLQ--DITMVACGDAFTLAIGAEGEVYTWG 642          

Query:  741 IRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEK-PLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQF--EPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTL------NLSPVRLPS---KIRIKQICSGENHTIVLTTDRTVFTW-----GSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGS------GISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLG-NGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            IR +G+GA+G A LYR+ +D+SLV+ KE++++ LS  ER+  MNE+ +LS L+H NI+AYF+ F +   L+IE+EY + G L   +  Q+  P  EK ++   +QI SA+ YIH+  ILHRD+KT+NIFLTK ++IK+GD+G++K L +    A + +GTPYY+SPE+CQG  YN KSD+WA+GC+LYE+  L +TF+ +N   L  KI++G +  E V   YS  L +L+   L ++P  R + E IL        +    +    ++++  + +     + S+  V     +        +P +L S       + +C+GENH  V+T ++ ++TW     G+   GQLGHGD    ++P+ V  L  K++ ++ACG DF+    +   +   GS      G+ G LG      VL+P L+E      V  +S  ++HVVV++ +  IY WG  + G+LGL+S + + SP  +       + +     D+T  LTE+G +LA GNN  NKLGLN  +  +        Q  I      T V+ + R  +  +S GK HT  + E G++I FG N  GQLG     K++ +   V       +TKV  G  FT+A  + N ++ WG
Sbjct:   44 IRILGRGAFGEATLYRRTEDNSLVVWKEVDLNSLSEKERRDVMNEINILSVLEHNNIIAYFNHFMDKNSLLIELEYCNGGNLYDKIVQQKGVPFSEKVVVWYLYQIASAVAYIHKAGILHRDIKTLNIFLTKTDLIKLGDYGLAKKLDSEFSMAETCVGTPYYMSPELCQGAKYNFKSDIWAMGCVLYEVLTLKRTFDATNPLNLCVKIVQGNWTMEGVSDIYSSGLLKLVYECLHQDPAKRPTAEHILDQPSISCCRQELEEQVVLLNSSMKRPKLNPVSESSIAVVTRSREVYYWGGGKFTPQKLDSFKAGSGAQHVCAGENHFAVVTVEKELYTWADVQGGAKMVGQLGHGDQASYRQPKRVEKLQGKAIRQVACGADFTACVTDEDQMYMFGSDYDGCIGVEGQLG----SQVLEPVLLEFFEGRPVQLVSCGDNHVVVLTRDKDIYSWGCGEYGRLGLESEDEFSSPMQVKVPIGASISSVSCGSDSTFFLTESGKVLACGNNEFNKLGLNQGISGIKNHPGEGYQ-GIPYTTAMTLVKQLSRFKIQSISPGKTHTAAIDERGRLITFGCNKFGQLGVKDFKKHAGVQVLVGPFGGKTVTKVACGDGFTIAATEDNQIFAWG 665          

Query: 1608 TLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPE-LVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLG 1901
            T  ++ V+  S+ +I+ I  G+ HT  +     + T+G N+FGQLG  D       + LV     K++ ++ACG+ F+I   E+  I   G+  +G LG
Sbjct:  575 TTAMTLVKQLSRFKIQSISPGKTHTAAIDERGRLITFGCNKFGQLGVKDFKKHAGVQVLVGPFGGKTVTKVACGDGFTIAATEDNQIFAWGNAGNGRLG 673          

Query:  780 LYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQ-EKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEE-IIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKT---FHTDSSD-----------------------NVDTAKPQTRNYEFEKRSV-------VYVMDINTLNLSPVRLP-SKIRIKQICSGENHTIVLTTDRTVFTWGSNEF--GQLGHGDLVDRKKPELVSSLTQK----SLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHC--VNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWG 2549
            L R++ D + VILKEI +  +S  ER  A NE +VL  L+HPNI+ Y+++F ED  LMI MEYA  GTLA+++  +    L+E  IL  F QI+ A++++H   ILHRDLKT NI L K + I+KIGDFGISK+L +  + A +V+GTP YISPE+C+GK YN+KSD+WALGC+LYE+  L + FE +NLPALV KI+ G F P+   YS EL++LI ++L  +P  R     I+   LP+  +     +TD  +                        V T++ +  ++ F    V       VY         +P RLP     + Q+  G    + +T    + TW +     G+LG   +V+  +   +S   +     ++  ++CG+ F+    E GIIMT GSG +G LGHG+F DV +P+++E+LL  ++V ++   SHVV V++E  ++ WG   NG+LGL + + + SPQ +        + A    D +M+++    ++A G+N  NKLGL+     +   +  SQ   +   H FT V++V  +   +  V +G  H+  + E G+   FG N  GQ+G  S ++  +P  V  ++   IT V  G  FT+A      +Y WG
Sbjct:   36 LCRRRSDGAFVILKEIPVEQMSRDERLAAQNECQVLKLLNHPNIIEYYENFLEDKALMIAMEYAPGGTLAEYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQNILLDKHQMIVKIGDFGISKILVSKSK-AYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIM--ALPICTRPLLNLYTDVGNVKMRRIEKPLSAVQLGLPGRPGGRVSTSRLREGSFGFGSGQVHSLPLSSVYTWGSGI--TTPFRLPMPNTEVLQVSLGRTQKMGVTKSGRLITWEAPSVGAGELGPPGVVEHMQLLFISRFLEGQSGVTIKSVSCGDLFTTCMTERGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVACGASHVVAVTNEREVFAWGRGDNGRLGLGTQDTHNSPQQVCLPVGFEAQRAVCGVDCSMIISSQSSIMACGSNRFNKLGLDR----ITAGEEPSQVNQVEEAHSFTPVQSVPLNTDKIVSVDIGTSHSAAVTEGGQCFTFGSNQHGQMGCSSRRSGRVPYLVLGLQ--DITMVACGDAFTLAIGAEGEVYTWG 658          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPL-EEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVIL 1478
            ++ +E ++ +G+G++G A+L   K+D    ++KEI +  +S  ER+ +  EV VL+ + HPNIV Y +SFE  G L I M+Y + G L + +++Q+  L  E +IL+ F QI  A+ ++H  KILHRD+K+ NIFLTK+  +++GDFGI+++L+T  E A + IGTPYY+SPE+C+ K YN K D+WALGC+LYEM  L   FE  N+  LV KI++G + PV   YS EL+ L++ L  +NP +R S   IL
Sbjct:    1 MDKYENVKQIGEGSFGKAILVNSKEDGRQYVIKEIGISGMSTKERRESRKEVSVLANMSHPNIVQYKESFE-GGCLYIVMDYCEGGDLFKKINSQKGVLFSEDQILDWFVQICLALKHVHGRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNTV-ELARTCIGTPYYLSPEICENKPYNNK-DIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSPELRSLLAQLFRRNPRERPSVSSIL 250          

Query:  723 INGFEKIRTVGKGAYGTAVLYRKK--DDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEK-PLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEI-IKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMK---TFHTDSSDNVDTAK 1547
            +N +E +  +G+GA+G A L R K    D+  ++K+IN+  +SA ER+ +  EV +LS++ HPNIV++  SF E G L I ME+ D G L + ++ Q   P  E++IL++F QI   + +IH+ K+LHRD+K  NIFLT   +  K+GDFGI++ML+ + + A + +GTPYY+SPE+C+ + YN K+DVW+LGC+LYE+  L   FEGS+L  L+ KI +G++ PV   Y+ EL+ L++ L + NP DR S   +L    P + K     H  S D+  T +
Sbjct:    1 MNDYEVLWQIGEGAFGKAFLVRSKTGGGDTQCVIKQINLQKMSAKERESSRKEVTLLSRMRHPNIVSFISSFLEKGSLFIVMEFCDGGDLLKKINMQRGVPFREEEILDLFVQICLGLKHIHDKKVLHRDIKCQNIFLTNGGMKAKLGDFGIARMLNNSMDLARTCVGTPYYLSPEICESRPYNNKTDVWSLGCVLYELCTLRHPFEGSSLRQLLGKICRGRYAPVPTRYTHELRLLVNQLFKVNPRDRPSISSVLQR--PFLQKHISKHHQASHDHAVTHR 280          

Query:  582 ILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNHXXXXXXXXXXXXXKEIENLKKRELTSIYERKTFSAVCAIQ 3539
            I +VECSISKDLWGSDIIIEHESHPSKIAA+FYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTK+SDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDS L+GNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQV  LEEKLKFQNHQILQNNLIINQLQKEIENLKKRELT IYERKTFSAVCAIQ
Sbjct:   10 ISIVECSISKDLWGSDIIIEHESHPSKIAAEFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKESDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSPLFGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVFFLEEKLKFQNHQILQNNLIINQLQKEIENLKKRELTRIYERKTFSAVCAIQ 995          

Query:  579 KILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNHXXXXXXXXXXXXXKEIENLKKRELTSIYERKTFSAVCAIQ 3539
            +++ VECSISKDLWGSDIIIEHESHPSKIAA+FYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR       SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTK+SDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDS L+GNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQV  LEEKLKFQNHQILQNNLIINQLQKEIENLKKRELT IYERKTFSAVCAIQ
Sbjct:    4 QMIFVECSISKDLWGSDIIIEHESHPSKIAAEFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR-------SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKESDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSPLFGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVFFLEEKLKFQNHQILQNNLIINQLQKEIENLKKRELTRIYERKTFSAVCAIQ 983          

Query:  582 ILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNHXXXXXXXXXXXXXKEIENLKKRELTSIYERKTFSAVCAIQ 3539
            I +VECSISKDLWGSDIIIEHESHPSKIAA+FYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR       SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTK+SDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDS L+GNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQV  LEEKLKFQNHQILQNNLIINQLQKEIENLKKRELT IYERKTFSAVCAIQ
Sbjct:   10 ISIVECSISKDLWGSDIIIEHESHPSKIAAEFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR-------SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKESDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSPLFGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVFFLEEKLKFQNHQILQNNLIINQLQKEIENLKKRELTRIYERKTFSAVCAIQ 988          

Query:  579 KILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNH 3419
            +++ VECSISKDLWGSDIIIEHESHPSKIAA+FYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR       SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTK+SDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDS L+GNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQV  LEEKLKFQNH
Sbjct:    4 QMIFVECSISKDLWGSDIIIEHESHPSKIAAEFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR-------SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKESDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSPLFGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVFFLEEKLKFQNH 943          

Query:  582 ILLVECSISKDLWGSDIIIEHESHPSKIAAKFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDXXXXXXXXXXXXNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTRNYEFEKRSVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETXXXXXXXXXXXXXXXXXXXXXFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKKSDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSSLYGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYXXXXXXXXXXXXXFQNH 3419
            ++ VECSISKDLWGSDIIIEHESHPSKIAA+FYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR       SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTK+SDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDS L+GNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQV  LEEKLKFQNH
Sbjct:    1 MIFVECSISKDLWGSDIIIEHESHPSKIAAEFYFSINNLISFSIQQTINGFEKIRTVGKGAYGTAVLYRKKDDDSLVILKEINMHDLSATERQLAMNEVKVLSQLDHPNIVAYFDSFEEDGVLMIEMEYADNGTLAQFLSNQEKPLEEKKILEMFFQIVSAIHYIHEHKILHRDLKTVNIFLTKEEIIKIGDFGISKMLSTTHEGANSVIGTPYYISPEMCQGKLYNEKSDVWALGCILYEMTCLHKTFEGSNLPALVNKILKGQFEPVKGSYSDELKELISSLLEKNPDDRLSTEVILHHKLPMMMKTFHTDSSDNVDTAKPQTR-------SVVYVMDINTLNLSPVRLPSKIRIKQICSGENHTIVLTTDRTVFTWGSNEFGQLGHGDLVDRKKPELVSSLTQKSLIRIACGNDFSIFGPENGIIMTCGSGISGSLGHGDFKDVLKPRLIESLLTIDVVCISATNSHVVVVSSEDVIYGWGSNKNGQLGLDSLNLYCSPQVITFKEHVLVKNAFTSEDATMLLTETGGLLASGNNNGNKLGLNARLGFLMTMKSLSQQPTINSVHEFTKVEAVMRHCVNQVSMGKGHTTVLCESGKIIAFGINSSGQLGNGSTKNSPIPCEVKTMKKHKITKVTSGSNFTVACVDFNSLYFWGIRQTKESDMRFLNGNESFKNKSQVINERPIEHFFRPAITSDEFLEAKQFSMPSNANGEINEESNEVMKIFPTPIVILHLKNPENNSKDKELICLTNCITFRDHSLLVQIETTAPPPRRRRSKTMPRIKIHDSPLFGNIHNAKITPKIIKSFCGENSESSPLSYEEGFETETVPTWIKNELIDAANDTQNNNAEFAGSRFLSTNTQSFNNKNEFPKNVLRIYSTSNHDNKLNETLTKKSTFNSIKSLSSRHRSLKTSKELSENPTTFKSEREIYLEKQVFFLEEKLKFQNH 939