cell division cycle 25-1

Overview
Namecell division cycle 25-1 (AFJ24796.1)
Smed IDSMED30006416
Length (bp)1432
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of cell division cycle 25-1 (SMED30006416) t-SNE clustered cells

Violin plots show distribution of expression levels for cell division cycle 25-1 (SMED30006416) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cell division cycle 25-1 (SMED30006416) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for cell division cycle 25-1 (SMED30006416) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30006416

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30006416h1SMcG0010223 dd_Smed_v4_5520_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30006416h1SMcG0010223 Contig1459GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Human
Match: CDC25C (cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727])

HSP 1 Score: 102.834 bits (255), Expect = 2.889e-23
Identity = 55/142 (38.73%), Postives = 80/142 (56.34%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            T+A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ + +    I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  236 TVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQKR---IIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 362
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Human
Match: CDC25C (cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727])

HSP 1 Score: 102.834 bits (255), Expect = 2.889e-23
Identity = 55/142 (38.73%), Postives = 80/142 (56.34%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            T+A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ + +    I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  236 TVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQKR---IIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 362
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Human
Match: CDC25C (cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727])

HSP 1 Score: 100.138 bits (248), Expect = 3.190e-23
Identity = 54/142 (38.03%), Postives = 78/142 (54.93%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
             +A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ +      I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  111 MVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQ---KRIIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 237
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Human
Match: CDC25C (cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727])

HSP 1 Score: 103.219 bits (256), Expect = 4.144e-23
Identity = 57/142 (40.14%), Postives = 81/142 (57.04%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            T+A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ + KR   I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  279 TVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQ-KR--IIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 405
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Human
Match: CDC25C (cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727])

HSP 1 Score: 102.834 bits (255), Expect = 5.891e-23
Identity = 57/142 (40.14%), Postives = 81/142 (57.04%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            T+A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ + KR   I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  309 TVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQ-KR--IIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 435
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Match: cdc-25.4 (Cell Division Cycle related [Source:UniProtKB/TrEMBL;Acc:Q21762])

HSP 1 Score: 82.4185 bits (202), Expect = 2.422e-17
Identity = 53/159 (33.33%), Postives = 81/159 (50.94%), Query Frame = 3 
Query:  642 ISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLD--RLAHCGSRDLFIPNIYVLNAGYRDFYNEYP--KFCFPRNYVSMKQTRYPLRNS 1106
            IS+   A++L  + +    + IFDCR+P+EY GGHI  A+N+Y+  +L + L+                    K      I +FYCE+S  R P MA+ LR +D  R  H  +  L  P IY+L+ GY +F+++      C PR Y+SM     P R++
Sbjct:   61 ISATVFASLLR-DRSRCLQLIIFDCRYPFEYFGGHIKGAVNIYSLDELGKYLY---------------DEYGVKSTLGGLIPIFYCEYSQVRGPAMARRLRKIDTHRNNHRAA-ALDFPEIYLLDKGYVNFWSDVSLRDLCEPRYYISMHAR--PFRHA 200
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Match: cdc-25.1 (M-phase inducer phosphatase cdc-25.1 [Source:UniProtKB/Swiss-Prot;Acc:O44552])

HSP 1 Score: 82.4185 bits (202), Expect = 1.917e-16
Identity = 42/140 (30.00%), Postives = 68/140 (48.57%), Query Frame = 3 
Query:  687 LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDR-LAHCGSRDLFIPNIYVLNAGYRDFYN--EYPKFCFPRNYVSMKQTRYPL 1097
             D    I DCRFP+EY GGH+  AIN++   ++  I FP     +  +               N + +FYCE+S  R P MA  +R +DR L       +  P +Y+L+ GY+  ++  E  + C P +Y+ M  + + +
Sbjct:  305 FDKKYIIVDCRFPFEYKGGHVKGAINLFRHDKIKPIFFPENGEASSFQ---------------NRVPIFYCEYSQKRGPTMAHAVRSIDRVLNELRYPHVEYPEMYLLDYGYKSLWSTAECRQICEPCSYIPMTHSSFSM 429
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Match: cdc-25.1 (M-phase inducer phosphatase cdc-25.1 [Source:UniProtKB/Swiss-Prot;Acc:O44552])

HSP 1 Score: 82.4185 bits (202), Expect = 1.917e-16
Identity = 42/140 (30.00%), Postives = 68/140 (48.57%), Query Frame = 3 
Query:  687 LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDR-LAHCGSRDLFIPNIYVLNAGYRDFYN--EYPKFCFPRNYVSMKQTRYPL 1097
             D    I DCRFP+EY GGH+  AIN++   ++  I FP     +  +               N + +FYCE+S  R P MA  +R +DR L       +  P +Y+L+ GY+  ++  E  + C P +Y+ M  + + +
Sbjct:  305 FDKKYIIVDCRFPFEYKGGHVKGAINLFRHDKIKPIFFPENGEASSFQ---------------NRVPIFYCEYSQKRGPTMAHAVRSIDRVLNELRYPHVEYPEMYLLDYGYKSLWSTAECRQICEPCSYIPMTHSSFSM 429
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Match: cdc-25.2 (M-phase inducer phosphatase cdc-25.2 [Source:UniProtKB/Swiss-Prot;Acc:O44628])

HSP 1 Score: 77.411 bits (189), Expect = 4.745e-15
Identity = 56/167 (33.53%), Postives = 79/167 (47.31%), Query Frame = 3 
Query:  642 ISSLTLANIL--SGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDR---LAHCGSRDLFIPNIYVLNAGYRDFY---NE--YPKFCFPRNYVSMKQTRYPLRNSEY 1112
            I++ TL +I         D+   + DCR+PYEY+ GHI NAIN +    + +I +                + N + KR N I +FYCEFS  R PKMA  LR +DR   + H    D     +YVL+ GYR+F+   NE      C P  Y  M    + +   +Y
Sbjct:  226 ITAETLRDIFFRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFY----------------DENGR-KRCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDY--EEMYVLDLGYRNFFFAANEANITNLCQPHAYCEMHDKEHTMELKKY 373
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Match: cdc-25.2 (M-phase inducer phosphatase cdc-25.2 [Source:UniProtKB/Swiss-Prot;Acc:O44628])

HSP 1 Score: 77.411 bits (189), Expect = 4.819e-15
Identity = 56/167 (33.53%), Postives = 79/167 (47.31%), Query Frame = 3 
Query:  642 ISSLTLANIL--SGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDR---LAHCGSRDLFIPNIYVLNAGYRDFY---NE--YPKFCFPRNYVSMKQTRYPLRNSEY 1112
            I++ TL +I         D+   + DCR+PYEY+ GHI NAIN +    + +I +                + N + KR N I +FYCEFS  R PKMA  LR +DR   + H    D     +YVL+ GYR+F+   NE      C P  Y  M    + +   +Y
Sbjct:  204 ITAETLRDIFFRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFY----------------DENGR-KRCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDY--EEMYVLDLGYRNFFFAANEANITNLCQPHAYCEMHDKEHTMELKKY 351
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Fly
Match: twe (gene:FBgn0002673 transcript:FBtr0331444)

HSP 1 Score: 97.4413 bits (241), Expect = 1.519e-21
Identity = 64/177 (36.16%), Postives = 88/177 (49.72%), Query Frame = 3 
Query:  597 LPIASDSTHNVLIPEISSLTLANILSGNH----TLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEY 1112
            LP  +    +  +  ISS TLA ++ G             I DCR+PYE+ GGHI  A N+YT  Q +Q  FP   S             N++ +R   IYVF+CEFSS R PK+ + LR  DR  H  +   L  P +Y+L+ GY++F+  Y + C P  YV M     P  N E+
Sbjct:  231 LPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQ-IQEAFPTLTS-------------NQENRR---IYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLA---PAHNDEF 387
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Fly
Match: twe (gene:FBgn0002673 transcript:FBtr0331445)

HSP 1 Score: 97.4413 bits (241), Expect = 1.519e-21
Identity = 64/177 (36.16%), Postives = 88/177 (49.72%), Query Frame = 3 
Query:  597 LPIASDSTHNVLIPEISSLTLANILSGNH----TLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEY 1112
            LP  +    +  +  ISS TLA ++ G             I DCR+PYE+ GGHI  A N+YT  Q +Q  FP   S             N++ +R   IYVF+CEFSS R PK+ + LR  DR  H  +   L  P +Y+L+ GY++F+  Y + C P  YV M     P  N E+
Sbjct:  231 LPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQ-IQEAFPTLTS-------------NQENRR---IYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLA---PAHNDEF 387
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Fly
Match: twe (gene:FBgn0002673 transcript:FBtr0331446)

HSP 1 Score: 97.4413 bits (241), Expect = 1.519e-21
Identity = 64/177 (36.16%), Postives = 88/177 (49.72%), Query Frame = 3 
Query:  597 LPIASDSTHNVLIPEISSLTLANILSGNH----TLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEY 1112
            LP  +    +  +  ISS TLA ++ G             I DCR+PYE+ GGHI  A N+YT  Q +Q  FP   S             N++ +R   IYVF+CEFSS R PK+ + LR  DR  H  +   L  P +Y+L+ GY++F+  Y + C P  YV M     P  N E+
Sbjct:  231 LPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQ-IQEAFPTLTS-------------NQENRR---IYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLA---PAHNDEF 387
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Fly
Match: twe (gene:FBgn0002673 transcript:FBtr0080855)

HSP 1 Score: 97.4413 bits (241), Expect = 1.519e-21
Identity = 64/177 (36.16%), Postives = 88/177 (49.72%), Query Frame = 3 
Query:  597 LPIASDSTHNVLIPEISSLTLANILSGNH----TLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEY 1112
            LP  +    +  +  ISS TLA ++ G             I DCR+PYE+ GGHI  A N+YT  Q +Q  FP   S             N++ +R   IYVF+CEFSS R PK+ + LR  DR  H  +   L  P +Y+L+ GY++F+  Y + C P  YV M     P  N E+
Sbjct:  231 LPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQ-IQEAFPTLTS-------------NQENRR---IYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLA---PAHNDEF 387
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Fly
Match: stg (gene:FBgn0003525 transcript:FBtr0085397)

HSP 1 Score: 97.4413 bits (241), Expect = 1.738e-21
Identity = 59/170 (34.71%), Postives = 90/170 (52.94%), Query Frame = 3 
Query:  588 GYLLPIASDSTHNVLIPEISSLTLANILSGNHTLD-NNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
             Y LP+      +  +  ISS T+A +L G  +    +  I DCR+PYE+ GGHI  A N+YT++Q+L     ++Q+       E     N +      I +F+CEFSS R PKM++ LR LDR  +  +   L  P IY+L+ GY++F+  + + C P  Y +M    Y
Sbjct:  284 AYALPLMEGRHRD--LKSISSETVARLLKGEFSDKVASYRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQT-------ELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAY 444
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Zebrafish
Match: cdc25d (cell division cycle 25 homolog d [Source:ZFIN;Acc:ZDB-GENE-090313-74])

HSP 1 Score: 112.849 bits (281), Expect = 6.600e-27
Identity = 74/222 (33.33%), Postives = 108/222 (48.65%), Query Frame = 3 
Query:  501 LDSYWIVNSEQSLSTLKPTSSPVNNCS----------ETGYLLPI--ASDSTHNVLIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIK------------QSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            +D    V   Q +S L+   +PV   +             +LLP+  A    H+     IS+ T+A+++ G   +   +  I DCR+PYEY GGHI  A+N+YT  Q+ Q+L                +S +D  L ED  + ++KL       +F+CEFSS R P + Q LR LDR  +     L  P +Y+L  GY+ F+  YP  C P  YVSM+Q  Y
Sbjct:  149 VDPMAAVRFRQLMSQLQAPPTPVTQVAVADLTLIGDFSKQHLLPVESAGHQEHHC----ISAQTVASLIRGQFGSAVEDFLIVDCRYPYEYQGGHIKGAVNLYTEHQVQQVLHQASAQVSVSTSRLCGRSASD-SLPEDEESPSRKL------IIFHCEFSSERGPHLCQYLRRLDRCVNVYP-SLHYPELYLLLGGYKHFHASYPDLCDPCGYVSMRQREY 358
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Zebrafish
Match: cdc25b (cell division cycle 25B [Source:ZFIN;Acc:ZDB-GENE-000330-5])

HSP 1 Score: 83.9593 bits (206), Expect = 8.465e-17
Identity = 46/152 (30.26%), Postives = 74/152 (48.68%), Query Frame = 3 
Query:  630 LIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            + PEI    +   +SG    L   + + DCR+PYEY GGHI  A+N++   Q+       PI   C  +++                + +F+CEFSS R P+M + +R  DR  +    +L  P +Y+L  GY++F+  +   C P+ Y  M
Sbjct:  398 ITPEI----MVKAMSGQFQDLVERLFVIDCRYPYEYEGGHIKGALNLHQEDQIEDYFLRSPILPDCPKKRV----------------LLIFHCEFSSERGPRMCRYVRERDRFVN-EYPNLHYPELYILKGGYKEFFQIHKAICEPQMYRPM 528
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Match: ENSXETT00000036492.1 (M-phase inducer phosphatase 3-like [Source:NCBI gene;Acc:100497395])

HSP 1 Score: 104.76 bits (260), Expect = 8.384e-24
Identity = 62/167 (37.13%), Postives = 85/167 (50.90%), Query Frame = 3 
Query:  588 GYLLPIASDSTHNVLIPEISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNL---NKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
             Y LP+       +    IS  TLA +L G +  +     I DCR+PYEY+GGHI  A N+Y                     EE IS+    N    +  T+ +F+CEFSS RAPK+ + LR LDR A+     L  P +Y+L  GY++FY ++  FC PR YV+M
Sbjct:  223 AYCLPLERGKHQELKY--ISCTTLARLLRGGYQDVVQQYQIVDCRYPYEYAGGHIKGAYNLYK--------------------EEHISDTFLKNATHPKSTTLLIFHCEFSSERAPKLCRLLRNLDRNAN-RYPHLHYPELYILKGGYKEFYEKFKGFCEPRGYVNM 366
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Match: cdc25c (cell division cycle 25C [Source:NCBI gene;Acc:100124300])

HSP 1 Score: 103.605 bits (257), Expect = 4.423e-23
Identity = 58/170 (34.12%), Postives = 88/170 (51.76%), Query Frame = 3 
Query:  591 YLLPIASDSTHNVLIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            Y LP  +    ++    I++ TLA ++ G+  +L  N+ I DCR+PYEY GGHI  A+N++  +++       P+  S   ++L                I VF+CEFSS R PKM + LR  DR A      L+ P +Y+L  GY+DF+ EY + C P+ Y  M    +
Sbjct:  370 YALPTVTGRHQDLRY--ITAETLAALIHGDFSSLVENVFIIDCRYPYEYDGGHIKGALNLHRQEEVTDYFLKQPLAPSVAQKRL----------------IIVFHCEFSSERGPKMCRFLREEDR-ARNEYPGLYYPELYLLKGGYKDFFPEYKELCEPQGYCPMHHQDF 520
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Match: cdc25c (cell division cycle 25C [Source:NCBI gene;Acc:100124300])

HSP 1 Score: 103.605 bits (257), Expect = 5.035e-23
Identity = 58/170 (34.12%), Postives = 88/170 (51.76%), Query Frame = 3 
Query:  591 YLLPIASDSTHNVLIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            Y LP  +    ++    I++ TLA ++ G+  +L  N+ I DCR+PYEY GGHI  A+N++  +++       P+  S   ++L                I VF+CEFSS R PKM + LR  DR A      L+ P +Y+L  GY+DF+ EY + C P+ Y  M    +
Sbjct:  380 YALPTVTGRHQDLRY--ITAETLAALIHGDFSSLVENVFIIDCRYPYEYDGGHIKGALNLHRQEEVTDYFLKQPLAPSVAQKRL----------------IIVFHCEFSSERGPKMCRFLREEDR-ARNEYPGLYYPELYLLKGGYKDFFPEYKELCEPQGYCPMHHQDF 530
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Match: adcy7 (adenylate cyclase 7 [Source:Xenbase;Acc:XB-GENE-1005225])

HSP 1 Score: 97.0561 bits (240), Expect = 6.237e-23
Identity = 53/141 (37.59%), Postives = 75/141 (53.19%), Query Frame = 3 
Query:  657 LANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            LA +L G +  +     I DCR+PYEY+GGHI  A N+Y  + +                  D    N    +  T+ +F+CEFSS RAPK+ + LR LDR A+     L  P +Y+L  GY++FY ++  FC PR YV+M
Sbjct:   11 LARLLRGGYQDVVQQYQIVDCRYPYEYAGGHIKGAYNLYKEEHI-----------------SDTFLKNATHPKSTTLLIFHCEFSSERAPKLCRLLRNLDRNAN-RYPHLHYPELYILKGGYKEFYEKFKGFCEPRGYVNM 133
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Match: cdc25c (cell division cycle 25C [Source:NCBI gene;Acc:100124300])

HSP 1 Score: 94.7449 bits (234), Expect = 4.252e-20
Identity = 60/168 (35.71%), Postives = 87/168 (51.79%), Query Frame = 3 
Query:  591 YLLPIASDSTHNVLIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            Y LP  +    ++    I++ TLA ++ G+  +L  N+ I DCR+PYEY GG          S  L   LF I Q  TD  L++ ++     + +   I VF+CEFSS R PKM + LR  DR A      L+ P +Y+L  GY+DF+ EY + C P+ Y  M    +
Sbjct:  360 YALPTVTGRHQDLRY--ITAETLAALIHGDFSSLVENVFIIDCRYPYEYDGGK---------SVVLFPFLF-ISQEVTDYFLKQPLA---PSVAQKRLIIVFHCEFSSERGPKMCRFLREEDR-ARNEYPGLYYPELYLLKGGYKDFFPEYKELCEPQGYCPMHHQDF 511
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Match: Cdc25b (cell division cycle 25B [Source:MGI Symbol;Acc:MGI:99701])

HSP 1 Score: 98.5969 bits (244), Expect = 1.675e-21
Identity = 51/148 (34.46%), Postives = 79/148 (53.38%), Query Frame = 3 
Query:  642 ISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            IS  T+  +L+G  + +     I DCR+PYEY GGHI NA+N+   +     L   PI     D+++                I +F+CEFSS R P+M + +R  DR A+     L+ P +Y+L  GY++F+ ++P FC P++Y  M
Sbjct:  385 ISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRI----------------ILIFHCEFSSERGPRMCRFIRERDRAAN-DYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPM 515
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Match: Cdc25b (cell division cycle 25B [Source:MGI Symbol;Acc:MGI:99701])

HSP 1 Score: 98.5969 bits (244), Expect = 1.782e-21
Identity = 51/148 (34.46%), Postives = 79/148 (53.38%), Query Frame = 3 
Query:  642 ISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            IS  T+  +L+G  + +     I DCR+PYEY GGHI NA+N+   +     L   PI     D+++                I +F+CEFSS R P+M + +R  DR A+     L+ P +Y+L  GY++F+ ++P FC P++Y  M
Sbjct:  411 ISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRI----------------ILIFHCEFSSERGPRMCRFIRERDRAAN-DYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPM 541
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Match: Cdc25c (cell division cycle 25C [Source:MGI Symbol;Acc:MGI:88350])

HSP 1 Score: 97.0561 bits (240), Expect = 3.048e-21
Identity = 57/146 (39.04%), Postives = 82/146 (56.16%), Query Frame = 3 
Query:  642 ISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            IS  T+A +LSG   ++     I DCR+PYEY GGHI  A+N+++ ++L +             L + +  L+ + KR   I VF CEFSS R P+M + LR  DR A      L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  278 ISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFF-----------LRKPVVPLDIQ-KR--VIIVFLCEFSSERGPRMCRSLREKDR-ALNQYPALYYPELYILKGGYRDFFPEYMELCDPQSYCPM 408
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Match: Cdc25a (cell division cycle 25A [Source:MGI Symbol;Acc:MGI:103198])

HSP 1 Score: 90.8929 bits (224), Expect = 5.228e-19
Identity = 56/171 (32.75%), Postives = 83/171 (48.54%), Query Frame = 3 
Query:  588 GYLLPIASDSTHNV--LIPEISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            GYL    S    ++  + PEI    +A++L+G    L     I DCR+PYEY GGHI  A+N++  +++   L       TD K                 I VF+CEFSS R P+M + +R  DRL +   + L  P +YVL  GY++F+ +    C P +Y  M    +
Sbjct:  334 GYLFNTVSGKHQDLKYISPEI----MASVLNGKFAGLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKNPIVPTDGK---------------RVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPK-LHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDF 484
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Match: Cdc25a (cell division cycle 25A [Source:MGI Symbol;Acc:MGI:103198])

HSP 1 Score: 85.8853 bits (211), Expect = 1.088e-17
Identity = 52/151 (34.44%), Postives = 76/151 (50.33%), Query Frame = 3 
Query:  588 GYLLPIASDSTHNV--LIPEISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFY 1031
            GYL    S    ++  + PEI    +A++L+G    L     I DCR+PYEY GGHI  A+N++  +++   L       TD K                 I VF+CEFSS R P+M + +R  DRL +   + L  P +YVL  GY++F+
Sbjct:  273 GYLFNTVSGKHQDLKYISPEI----MASVLNGKFAGLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKNPIVPTDGK---------------RVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPK-LHYPELYVLKGGYKEFF 403
[Close]
BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Match: sp|P23748|MPIP_YEAST (M-phase inducer phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MIH1 PE=1 SV=2)

HSP 1 Score: 107.457 bits (267), Expect = 1.297e-23
Identity = 60/158 (37.97%), Postives = 87/158 (55.06%), Query Frame = 3 
Query:  612 DSTHNVLIPEISSLTLANILSGN--HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            D   N   P IS  TL NIL  N   +  N+  I DCRF YEY+GGHI N++N+++  +L       +     + L  D SN N  L    T+ + +CEFSS+R P +A  LR  DR+ +      LF P+I +L+ GY+  ++ +P+ C+PR YV M
Sbjct:  234 DRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDEL-------EYEFIHKVLHSDTSN-NNTLP---TLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGM 380
[Close]
BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Match: sp|P30307|MPIP3_HUMAN (M-phase inducer phosphatase 3 OS=Homo sapiens OX=9606 GN=CDC25C PE=1 SV=2)

HSP 1 Score: 102.834 bits (255), Expect = 2.829e-22
Identity = 57/142 (40.14%), Postives = 81/142 (57.04%), Query Frame = 3 
Query:  654 TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            T+A +LSG    L     + DCR+PYEY GGHI  A+N+Y+ ++L               L++ I  L+ + KR   I VF+CEFSS R P+M +CLR  DR  +     L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  309 TVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFF-----------LKKPIVPLDTQ-KR--IIIVFHCEFSSERGPRMCRCLREEDRSLN-QYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 435
[Close]
BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Match: sp|P30309|MPI1B_XENLA (M-phase inducer phosphatase 1-B OS=Xenopus laevis OX=8355 GN=cdc25-1-b PE=1 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 2.565e-21
Identity = 58/168 (34.52%), Postives = 89/168 (52.98%), Query Frame = 3 
Query:  591 YLLPIASDSTHNVLIPEISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            Y LP  +    ++    I+  TLA ++ G+  +L   I I DCR+PYEY GGHI  A+N++  +++           TD  L++    L   + +   I +F+CEFSS R PKM + LR  DR A      L+ P +Y+L  GY+DF+ EY + C P++Y  M    +
Sbjct:  370 YALPTVTGRHQDLRY--ITGETLAALIHGDFSSLVEKIFIIDCRYPYEYDGGHIKGALNLHRQEEV-----------TDYFLKQP---LTPTMAQKRLIIIFHCEFSSERGPKMCRFLREEDR-ARNEYPSLYYPELYLLKGGYKDFFPEYKELCEPQSYCPMHHQDF 520
[Close]
BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Match: sp|Q29029|MPIP3_PIG (M-phase inducer phosphatase 3 OS=Sus scrofa OX=9823 GN=CDC25C PE=3 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 4.066e-21
Identity = 60/172 (34.88%), Postives = 85/172 (49.42%), Query Frame = 3 
Query:  600 PIASDSTHNVLIPEISSL----------TLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            P+  D +    +P +S            T+A +LSG    L     I DCR+PYEY GGHI  A+N+Y+ ++L       PI    T +++                I VF+CEFSS R P+M + LR  DR A      L+ P +Y+L  GYRDF+ EY + C P++Y  M
Sbjct:  310 PLIGDFSKVCALPTVSGRHQDLKYVNPETVAALLSGKFQGLIEKFYIIDCRYPYEYLGGHIQGALNLYSQEELCNFFLKKPIIPLDTQKRI----------------IVVFHCEFSSERGPRMCRSLREEDR-ALNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPM 464
[Close]
BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Match: sp|P48966|MPIP2_RAT (M-phase inducer phosphatase 2 OS=Rattus norvegicus OX=10116 GN=Cdc25b PE=1 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 4.101e-21
Identity = 57/159 (35.85%), Postives = 88/159 (55.35%), Query Frame = 3 
Query:  642 ISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDIS--NLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQT--RYPLRN 1103
            IS  T+  +L+G  + +     I DCR+PYEY GGHI NA+N+           P++       L+  I+  NL+K++     I +F+CEFSS R P+M + +R  DR A+     L+ P +Y+L  GY++F+ ++P FC P++Y  M     R  LRN
Sbjct:  409 ISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNL-----------PLEPDAETFLLKHPITPCNLDKRI-----ILIFHCEFSSERGPRMCRFIRERDRAAN-DYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHAAFRDELRN 550
[Close]
BLAST of cell division cycle 25-1 vs. TrEMBL
Match: I1ZIE2 (Cell division cycle 25-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 578.941 bits (1491), Expect = 0.000e+0
Identity = 283/283 (100.00%), Postives = 283/283 (100.00%), Query Frame = 3 
Query:   81 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKM 929
            MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKM
Sbjct:    1 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKM 283
[Close]
BLAST of cell division cycle 25-1 vs. TrEMBL
Match: A0A172RVQ2 (CDC25-3 protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=CDC25-3 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 1.792e-60
Identity = 99/172 (57.56%), Postives = 128/172 (74.42%), Query Frame = 3 
Query:  564 PVNNCSE-TGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            P+ + SE T YLLPI +++T ++ IP+ISSLTLA ++SGNHTL+N I IFDCRFPYEYS GHI N+ NV+  Q LLQ LFPI +S   R   +D   L + LK D+TIYVFYCE+SSYRAP +AQC+R LDR+ +  + +LFIPNIY+L  GYR+F+  YP  C P+ Y+SM
Sbjct:   54 PITDLSESTEYLLPITTETTGHLFIPQISSLTLAKLISGNHTLNNPIEIFDCRFPYEYSAGHIVNSKNVHNKQMLLQTLFPISESTLSRHSTDDA--LKENLKNDDTIYVFYCEYSSYRAPDLAQCIRELDRIVNVQAGNLFIPNIYILTGGYREFFYSYPTLCCPQGYMSM 223
[Close]
BLAST of cell division cycle 25-1 vs. TrEMBL
Match: A0A172RVS8 (CDC25-2 protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=CDC25-2 PE=2 SV=2)

HSP 1 Score: 162.925 bits (411), Expect = 6.368e-43
Identity = 99/258 (38.37%), Postives = 152/258 (58.91%), Query Frame = 3 
Query:  597 LPIASDSTHN-VLIPEISSLTLANILSGNHTL-DNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKR--------DNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRD-LFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRN--SEYISEND---------EFSSVMSKNQ-------------YRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLF 1265
            LPI  +S+ N +LIPEIS+ TL+++L G ++   ++  I DCRFPYEY GGHI+N+INVYT +Q++Q         T   +E+D+ ++ K  +         D   ++FYCEFSS+R PK+A+CLRGLD+L++  S   +  P++YVL+ GY +F+ +YP+ C P+ Y+SMKQTRY LR+  + Y+  N          E  SV   N              YRK++    R+ +   K+L  I+   TK++DI++ F
Sbjct:   19 LPIMRESSLNHLLIPEISNQTLSDLLVGRYSCYLSDYIIIDCRFPYEYDGGHISNSINVYTCRQMMQYFC----QSTQPDMEQDLQHVLKLFESPNSSEDDFDTKAFIFYCEFSSFRGPKLAECLRGLDKLSNLESLPRVKFPHVYVLHGGYNEFFIKYPELCTPQGYISMKQTRYALRSPINPYLMANSPTKHGNLTVESDSVRVPNVLTPKLTDEVTCTLYRKQQINCQRQLRCDIKRLVDIVQTITKNNDIIRFF 272
[Close]
BLAST of cell division cycle 25-1 vs. TrEMBL
Match: B4JLP3 (GH24474 OS=Drosophila grimshawi OX=7222 GN=Dgri\GH24474 PE=4 SV=1)

HSP 1 Score: 122.479 bits (306), Expect = 8.631e-28
Identity = 75/195 (38.46%), Postives = 103/195 (52.82%), Query Frame = 3 
Query:  534 SLSTLKPTSSPVNNCSE-TGYL-----LPIASDSTHNVLIPEISSLTLANILSGN--HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLF-IPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            + +T+K + + V N ++ TG L     LP+      N  +P ISS TLA +L G+    + NN  I DCR+PYE+ GGHI  A N+YT  Q ++  FP + S   R                N+IYVF+CEFSS+RAP + + LR  DR AH     L   P +Y+L  GY++F+  Y   C P NYV M    Y
Sbjct:   54 ATTTIKKSDADVLNVAQLTGDLSKPLTLPVLHGGMRNSDLPTISSATLARLLRGDFFKLVSNNYQIIDCRYPYEFHGGHIRGARNLYTHDQ-IRAAFPAEASIVAR----------------NSIYVFHCEFSSHRAPTLMRFLRTTDRNAHTDDYPLLDYPELYLLYKGYKEFHTSYTNLCNPNNYVPMLAPEY 231
[Close]
BLAST of cell division cycle 25-1 vs. TrEMBL
Match: A0A2R5LFZ3 (Putative m-phase inducer phosphatase (Fragment) OS=Ornithodoros turicata OX=34597 PE=4 SV=1)

HSP 1 Score: 119.783 bits (299), Expect = 4.933e-26
Identity = 68/184 (36.96%), Postives = 99/184 (53.80%), Query Frame = 3 
Query:  591 YLLPIASDSTHNVLIPEISSLTLANILSG--NHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEF 1133
            Y LP+      ++ +  IS +TLA +L G  NH++     + DCR+PYEY GGHI+ A+N+YT + L+  L P           E ++N  +K      + VF+CEFSS R PKM++ LR +DR  H      L  P IYVL  GY+ F+  +  FC P  YV       P+R+ ++ +E  EF
Sbjct:  208 YALPLMKGKHDDLKM--ISPVTLAEVLEGKYNHSV-KEYAVIDCRYPYEYEGGHISGAVNIYTREDLMSCLLP-----------EKMTNQEQK------VLVFHCEFSSERGPKMSRFLRNMDRQMHNEMYPKLKYPEIYVLEGGYKAFFEGFKSFCVPEMYV-------PMRHKDHETELKEF 364
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Cavefish
Match: CDC25B (cell division cycle 25B [Source:HGNC Symbol;Acc:HGNC:1726])

HSP 1 Score: 82.8037 bits (203), Expect = 1.678e-16
Identity = 50/170 (29.41%), Postives = 84/170 (49.41%), Query Frame = 3 
Query:  597 LPIASDSTHNV--LIPEISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            LP  S    ++  + PE+    +   +SG  + +   + + DCR+PYE+ GGHI  A+N++  +Q+    F  P      D+++                + VF+CEFSS R P+M + +R  DR  +    +L  P +YVL  GY+DF+  + + C P++Y  M    Y
Sbjct:  378 LPTVSGKHQDLKYITPEV----MVAAMSGQFSDVVERLFVIDCRYPYEFEGGHIKGALNLHLEEQIEDRFFSQPFLPQSPDKRV----------------LLVFHCEFSSERGPRMCRFVRERDRDLN-EYPNLHYPELYVLKGGYKDFFPLHKRECEPQDYRPMVHEDY 526
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Cavefish
Match: cdc25d (cell division cycle 25 homolog d [Source:ZFIN;Acc:ZDB-GENE-090313-74])

HSP 1 Score: 69.707 bits (169), Expect = 6.863e-13
Identity = 62/201 (30.85%), Postives = 88/201 (43.78%), Query Frame = 3 
Query:  600 PIASDSTHNVLIPE---------ISSLTLANILSGNHT-LDNNITIFDCRFPYEYSGGHIA--NAINVYTSQQLLQILF---------PIKQSCTDRKLEE----------------------DISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHC-GSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYV 1070
            P + D  H+VL  E         +S+ T+A +++   + +  +  I DCR+PYE+ GGHI    A+N+YT  Q+ Q            P  Q   D +  E                      +I +      R   + VF+CEFSS R P+  Q LR LDR  +      L  P +Y+L  GY+ FY  YP  C P NYV
Sbjct:   64 PQSPDPEHHVLPVERVGYQELHCVSAQTVAGLITAQFSAVVEDFLIIDCRYPYEFKGGHIKLQGAVNLYTEHQIHQAFLQSFSNFQTSPGAQQ--DPRSPEAGAVGGVQGPGSGGSRSSAVSGEIKDGGSSCPRK--LIVFHCEFSSERGPR-CQYLRELDRAVNTQNYPLLLYPELYLLQGGYKHFYTHYPDLCDPCNYV 259
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Yeast
Match: MIH1 (Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 [Source:SGD;Acc:S000004639])

HSP 1 Score: 107.457 bits (267), Expect = 1.867e-25
Identity = 60/158 (37.97%), Postives = 87/158 (55.06%), Query Frame = 3 
Query:  612 DSTHNVLIPEISSLTLANILSGN--HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGS-RDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            D   N   P IS  TL NIL  N   +  N+  I DCRF YEY+GGHI N++N+++  +L       +     + L  D SN N  L    T+ + +CEFSS+R P +A  LR  DR+ +      LF P+I +L+ GY+  ++ +P+ C+PR YV M
Sbjct:  234 DRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDEL-------EYEFIHKVLHSDTSN-NNTLP---TLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGM 380
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Nematostella
Match: EDO39841 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8Z1])

HSP 1 Score: 94.7449 bits (234), Expect = 8.706e-23
Identity = 63/187 (33.69%), Postives = 100/187 (53.48%), Query Frame = 3 
Query:  537 LSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLD-NNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSR-DLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            LS  +   + + + S+T Y+LP  +    ++    IS  T+  +++G++  + +   I DCR+P+E+ GGH+  AIN+YT  ++L      KQ     K +E         KR   + +F+CEFSS R P M + LR  DR  H  S   LF P +Y+L+ GY++F+N   + C P+NYV M    Y
Sbjct:    4 LSIAESNRNLIGDFSKT-YVLPSITGQHEDLKC--ISPETVTKLINGDYKDEIDEYYIIDCRYPFEFDGGHVKGAINIYTKDEML------KQFIDTPKCKEG--------KR--VVVIFHCEFSSKRGPDMCRFLRNRDRDIHRPSYPSLFYPELYLLDGGYKNFFNTCKEHCEPQNYVLMLDENY 171
[Close]
BLAST of cell division cycle 25-1 vs. Ensembl Medaka
Match: ENSORLT00000022793.2 (cell division cycle 25B [Source:NCBI gene;Acc:101168663])

HSP 1 Score: 91.6633 bits (226), Expect = 2.168e-19
Identity = 48/153 (31.37%), Postives = 79/153 (51.63%), Query Frame = 3 
Query:  642 ISSLTLANILSGN-HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILF--PIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRY 1091
            I+S  +   LSG+ H + + + + DCR+PYE+ GGHI  A+N +   Q+ + L   PI  S  ++++                + VF+CEFSS R P+M + +R  DR  +   + L  P +Y+L  GY+DF+  +   C P+ Y  M    +
Sbjct:  407 ITSDMMVAALSGHFHEVVDQVIVIDCRYPYEFEGGHIKGALNFHLESQVEEFLLRTPIVPSSPEKRV----------------VVVFHCEFSSERGPRMCRFIRERDRALNDYPK-LHYPELYILKGGYKDFFPHFQAQCEPQAYRPMHHEDF 542
[Close]
BLAST of cell division cycle 25-1 vs. Planmine SMEST
Match: SMESG000065054.1 (SMESG000065054.1)

HSP 1 Score: 828.935 bits (2140), Expect = 0.000e+0
Identity = 403/404 (99.75%), Postives = 403/404 (99.75%), Query Frame = 3 
Query:   81 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVMSKNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN 1292
            MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVM KNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN
Sbjct:    1 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVMCKNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN 404
[Close]
BLAST of cell division cycle 25-1 vs. Planmine SMEST
Match: SMESG000065054.1 (SMESG000065054.1)

HSP 1 Score: 785.793 bits (2028), Expect = 0.000e+0
Identity = 387/404 (95.79%), Postives = 387/404 (95.79%), Query Frame = 3 
Query:   81 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVMSKNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN 1292
            MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAIN                SCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVM KNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN
Sbjct:    1 MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKSYFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCRNNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSEQSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGNHTLDNNITIFDCRFPYEYSGGHIANAIN----------------SCTDRKLEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVMCKNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPIIGGN 388
[Close]
BLAST of cell division cycle 25-1 vs. Planmine SMEST
Match: SMESG000054042.1 (SMESG000054042.1)

HSP 1 Score: 164.081 bits (414), Expect = 6.753e-45
Identity = 101/258 (39.15%), Postives = 154/258 (59.69%), Query Frame = 3 
Query:  597 LPIASDSTHN-VLIPEISSLTLANILSGNHTL-DNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRKLEEDISNLNKKLKR--------DNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRD-LFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRN--SEYISEND---------EFSSVMSKNQ-------------YRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLF 1265
            LPI  +S+ N +LIPEIS+ TL+++L G ++   ++  I DCRFPYEY GGHI+N+INVYT +Q++Q      QS T   +E+D+ ++ K  +         D   ++FYCEFSS+R PK+A+CLRGLD+L++  S   +  P++YVL+ GY +F+ +YP+ C P+ Y+SMKQTRY LR+  + Y+  N          E  SV   N              YRK++    R+ +   K+L  I+   TK++DI++ F
Sbjct:  225 LPIMRESSLNHLLIPEISNQTLSDLLVGRYSCYLSDYIIIDCRFPYEYDGGHISNSINVYTCRQMMQYFC---QS-TQPDMEQDLQHVLKLFESPNSSEDDFDTKAFIFYCEFSSFRGPKLAECLRGLDKLSNLESLPRVKFPHVYVLHGGYNEFFIKYPELCTPQGYISMKQTRYALRSPINPYLMANSPTKHGNLTVESDSVRVPNVLTPKLTDEVTCTLYRKQQINCQRQLRCDIKRLVDIVQTITKNNDIIRFF 478
[Close]
BLAST of cell division cycle 25-1 vs. Planmine SMEST
Match: SMESG000075488.1 (SMESG000075488.1)

HSP 1 Score: 114.39 bits (285), Expect = 3.316e-27
Identity = 69/222 (31.08%), Postives = 120/222 (54.05%), Query Frame = 3 
Query:  621 HNVLIPEISSLTLANILSGNHTLDN-NITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFP-------IKQSCTDRKLEE-DISNLNKKLKRDNT-----IYVFYCEFSSYRAPKMAQCLRGLDRLAH--CGSRDLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDEFSSVMSKN------QYRKEEKQYMRETQDSEKKLRM 1220
            +++ I E+S+  +A I+  + T D+    I DCR+PYEY GGH+  A+N+YT  QLL  +F        +KQ   + +    D+ N    +K+ N+      ++F+CEFSS R P+MA+C+R +DR  +  C S +LF P ++++  GYR+FY+++   C P  YV M        N  +  + DE     S N       ++ + K Y +  ++S+ ++++
Sbjct:  267 NDIKITEVSADFVAKIIENDFTSDSYAYHIIDCRYPYEYDGGHLLGAVNLYTPWQLLNYIFLAQNDLEYLKQPVENTEDSMVDLINTIINIKKPNSSWKTEAFIFHCEFSSVRGPEMARCMRNMDRYVNFSCQS-NLFFPKVHIMKKGYREFYSKHKSLCSPCGYVKMDIKDPTCVNDSFSDDGDESPLTKSSNPILDVETWKAQVKMYNQCKKESQDQMKL 487
[Close]
BLAST of cell division cycle 25-1 vs. Planmine SMEST
Match: SMESG000025390.1 (SMESG000025390.1)

HSP 1 Score: 103.605 bits (257), Expect = 2.900e-24
Identity = 63/163 (38.65%), Postives = 90/163 (55.21%), Query Frame = 3 
Query:  609 SDSTHNVL-IPEISSLTLANILSGNHTLDN-NITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFP---IKQSCTDRKLEEDISN-LNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSR-DLFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSM 1076
            S+ T N++ I +I    +  I+  N+T+D  N  I D RFP+E++GGHI  A+N+YT   + Q  F    +K       LE  + N +N +    N   +F+CEFSS RAPKMA+ LR +DR A+      LF P I++L  GYR FY    + C P +Y  M
Sbjct:   93 SEPTDNIITIEDIDVDRVKKIVENNYTIDGLNYCIIDSRFPFEFNGGHIIGAVNLYTPLDVFQYFFGPDQLKTQSDKDNLELVVRNIINLQKFSSNLNLIFHCEFSSARAPKMAEELRCIDRFANLDCYPHLFYPKIFILKGGYRAFYMNNKELCEPSSYRKM 255
The following BLAST results are available for this feature:
BLAST of cell division cycle 25-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CDC25C2.889e-2338.73cell division cycle 25C [Source:HGNC Symbol;Acc:HG... [more]
CDC25C2.889e-2338.73cell division cycle 25C [Source:HGNC Symbol;Acc:HG... [more]
CDC25C3.190e-2338.03cell division cycle 25C [Source:HGNC Symbol;Acc:HG... [more]
CDC25C4.144e-2340.14cell division cycle 25C [Source:HGNC Symbol;Acc:HG... [more]
CDC25C5.891e-2340.14cell division cycle 25C [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdc-25.42.422e-1733.33Cell Division Cycle related [Source:UniProtKB/TrE... [more]
cdc-25.11.917e-1630.00M-phase inducer phosphatase cdc-25.1 [Source:UniP... [more]
cdc-25.11.917e-1630.00M-phase inducer phosphatase cdc-25.1 [Source:UniP... [more]
cdc-25.24.745e-1533.53M-phase inducer phosphatase cdc-25.2 [Source:UniP... [more]
cdc-25.24.819e-1533.53M-phase inducer phosphatase cdc-25.2 [Source:UniP... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
twe1.519e-2136.16gene:FBgn0002673 transcript:FBtr0331444[more]
twe1.519e-2136.16gene:FBgn0002673 transcript:FBtr0331445[more]
twe1.519e-2136.16gene:FBgn0002673 transcript:FBtr0331446[more]
twe1.519e-2136.16gene:FBgn0002673 transcript:FBtr0080855[more]
stg1.738e-2134.71gene:FBgn0003525 transcript:FBtr0085397[more]
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BLAST of cell division cycle 25-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cdc25d6.600e-2733.33cell division cycle 25 homolog d [Source:ZFIN;Acc:... [more]
cdc25b8.465e-1730.26cell division cycle 25B [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000036492.18.384e-2437.13M-phase inducer phosphatase 3-like [Source:NCBI ge... [more]
cdc25c4.423e-2334.12cell division cycle 25C [Source:NCBI gene;Acc:1001... [more]
cdc25c5.035e-2334.12cell division cycle 25C [Source:NCBI gene;Acc:1001... [more]
adcy76.237e-2337.59adenylate cyclase 7 [Source:Xenbase;Acc:XB-GENE-10... [more]
cdc25c4.252e-2035.71cell division cycle 25C [Source:NCBI gene;Acc:1001... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cdc25b1.675e-2134.46cell division cycle 25B [Source:MGI Symbol;Acc:MGI... [more]
Cdc25b1.782e-2134.46cell division cycle 25B [Source:MGI Symbol;Acc:MGI... [more]
Cdc25c3.048e-2139.04cell division cycle 25C [Source:MGI Symbol;Acc:MGI... [more]
Cdc25a5.228e-1932.75cell division cycle 25A [Source:MGI Symbol;Acc:MGI... [more]
Cdc25a1.088e-1734.44cell division cycle 25A [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of cell division cycle 25-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P23748|MPIP_YEAST1.297e-2337.97M-phase inducer phosphatase OS=Saccharomyces cerev... [more]
sp|P30307|MPIP3_HUMAN2.829e-2240.14M-phase inducer phosphatase 3 OS=Homo sapiens OX=9... [more]
sp|P30309|MPI1B_XENLA2.565e-2134.52M-phase inducer phosphatase 1-B OS=Xenopus laevis ... [more]
sp|Q29029|MPIP3_PIG4.066e-2134.88M-phase inducer phosphatase 3 OS=Sus scrofa OX=982... [more]
sp|P48966|MPIP2_RAT4.101e-2135.85M-phase inducer phosphatase 2 OS=Rattus norvegicus... [more]
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BLAST of cell division cycle 25-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZIE20.000e+0100.00Cell division cycle 25-1 OS=Schmidtea mediterranea... [more]
A0A172RVQ21.792e-6057.56CDC25-3 protein (Fragment) OS=Schmidtea mediterran... [more]
A0A172RVS86.368e-4338.37CDC25-2 protein (Fragment) OS=Schmidtea mediterran... [more]
B4JLP38.631e-2838.46GH24474 OS=Drosophila grimshawi OX=7222 GN=Dgri\GH... [more]
A0A2R5LFZ34.933e-2636.96Putative m-phase inducer phosphatase (Fragment) OS... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CDC25B1.678e-1629.41cell division cycle 25B [Source:HGNC Symbol;Acc:HG... [more]
cdc25d6.863e-1330.85cell division cycle 25 homolog d [Source:ZFIN;Acc:... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of cell division cycle 25-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
MIH11.867e-2537.97Protein tyrosine phosphatase involved in cell cycl... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO398418.706e-2333.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of cell division cycle 25-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSORLT00000022793.22.168e-1931.37cell division cycle 25B [Source:NCBI gene;Acc:1011... [more]
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BLAST of cell division cycle 25-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000065054.10.000e+099.75SMESG000065054.1[more]
SMESG000065054.10.000e+095.79SMESG000065054.1[more]
SMESG000054042.16.753e-4539.15SMESG000054042.1[more]
SMESG000075488.13.316e-2731.08SMESG000075488.1[more]
SMESG000025390.12.900e-2438.65SMESG000025390.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30006416
GenBankAFJ24796.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30006416 ID=SMED30006416|Name=cell division cycle 25-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1432bp
AAACAAATTAGAGCAATCTTTGTTCTAGTGAATATCTACAGGACTTTTTA
TTGCAATAAAGAATTGCTAATTTTGGAACAATGCAAAATCGAAAGAGGTT
GGCTCCTTATTGCAAATCTAACACAGATTTATTAAAACCGAATGTGATAC
AACCAATTGATGAAATTTTTGAAAATGATATTTTACCAAAATATGCAAAA
TATGAACAAACGGATTATAATCACAAGTCATATTTTGCAACTCCTGGAGA
GTGCACAAGATCTAAAACAACAAAATATAAAATAAATCCTTTTGATTTAT
CAAATCCAGAGCCTCAAAATATCACCTTTGATAATTTTATATCATCTACT
CGAAGAAATAGAGCAAGGTCAAAATGTAGAAACAATGAACTTAATTTTTG
CGAAAATTCCCTAGATTCTGGATTTGACACTGAAAGTGTTTCTGAAAGTA
TTTTGTCATTTGCAACTAAATCTAGTGATGAGAACAGTCGATCAAGTTTA
CTGGATAGTTACTGGATTGTAAATTCAGAACAGTCATTATCAACACTAAA
ACCAACATCAAGCCCAGTTAACAACTGTTCTGAAACCGGATATTTATTAC
CAATTGCTTCGGATTCTACACATAATGTTCTGATACCAGAAATTTCATCG
TTAACTCTTGCTAATATTTTATCCGGTAATCATACACTGGACAACAACAT
AACCATTTTCGATTGTCGGTTTCCATACGAGTATAGTGGCGGTCATATTG
CTAATGCAATAAACGTATACACTAGTCAACAATTACTTCAGATTTTATTT
CCAATTAAACAGTCGTGTACAGATAGAAAACTGGAAGAAGATATTAGCAA
CTTAAATAAGAAATTGAAACGTGATAACACAATTTATGTTTTCTACTGTG
AATTCAGCAGCTATAGAGCACCGAAAATGGCTCAATGTTTGAGGGGTTTG
GATCGATTGGCTCATTGTGGTAGTAGAGACTTATTTATTCCGAATATTTA
TGTTTTGAATGCTGGATACCGAGATTTTTATAATGAATATCCGAAATTCT
GCTTTCCACGAAATTATGTTAGTATGAAACAAACTCGGTATCCACTCAGA
AATAGTGAGTATATTTCTGAAAACGATGAGTTCTCCTCGGTAATGAGCAA
AAATCAATATCGTAAAGAAGAGAAACAGTATATGCGGGAAACTCAGGATT
CAGAAAAAAAGCTAAGAATGATTATAACACGATCTACAAAAGACAGTGAT
ATTTTACAATTGTTTTTATCTCATCCGATAATTGGAGGCAATTGATGTAA
TTTCGCGATGATTTACGAGTCAGATTTTCTGTGATATATTTACTTCTTTT
ACAATGATTTTGTATATAAATGTAAAAATATGAATTTATTTAAATTAAAA
TTCAATGTTCTCTAATGTGTATATTGTAATTG
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protein sequence of SMED30006416-orf-1

>SMED30006416-orf-1 ID=SMED30006416-orf-1|Name=SMED30006416-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=405bp
MQNRKRLAPYCKSNTDLLKPNVIQPIDEIFENDILPKYAKYEQTDYNHKS
YFATPGECTRSKTTKYKINPFDLSNPEPQNITFDNFISSTRRNRARSKCR
NNELNFCENSLDSGFDTESVSESILSFATKSSDENSRSSLLDSYWIVNSE
QSLSTLKPTSSPVNNCSETGYLLPIASDSTHNVLIPEISSLTLANILSGN
HTLDNNITIFDCRFPYEYSGGHIANAINVYTSQQLLQILFPIKQSCTDRK
LEEDISNLNKKLKRDNTIYVFYCEFSSYRAPKMAQCLRGLDRLAHCGSRD
LFIPNIYVLNAGYRDFYNEYPKFCFPRNYVSMKQTRYPLRNSEYISENDE
FSSVMSKNQYRKEEKQYMRETQDSEKKLRMIITRSTKDSDILQLFLSHPI
IGGN*
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Aliases
The feature 'cell division cycle 25-1' has the following synonyms
Synonym
cdc25-1
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:1902751positive regulation of cell cycle G2/M phase transition
GO:0006470protein dephosphorylation
GO:0035335peptidyl-tyrosine dephosphorylation
Vocabulary: INTERPRO
TermDefinition
IPR036873Rhodanese-like_dom_sf
IPR001763Rhodanese-like_dom
Vocabulary: molecular function
TermDefinition
GO:0004725protein tyrosine phosphatase activity
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 357..377
NoneNo IPR availablePANTHERPTHR10828M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25coord: 77..377
NoneNo IPR availablePANTHERPTHR10828:SF17CDC25-LIKE PROTEIN PHOSPHATASE TWINE-RELATEDcoord: 77..377
IPR001763Rhodanese-like domainSMARTSM00450rhod_4coord: 189..322
e-value: 6.3E-17
score: 72.2
IPR001763Rhodanese-like domainPFAMPF00581Rhodanesecoord: 205..318
e-value: 2.0E-11
score: 44.3
IPR001763Rhodanese-like domainPROSITEPS50206RHODANESE_3coord: 203..325
score: 14.928
IPR036873Rhodanese-like domain superfamilyGENE3DG3DSA:3.40.250.10coord: 165..378
e-value: 1.8E-45
score: 156.5
IPR036873Rhodanese-like domain superfamilySUPERFAMILYSSF52821Rhodanese/Cell cycle control phosphatasecoord: 186..340