Piezo-type mechanosensitive ion channel component
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30006368 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 399.438 bits (1025), Expect = 2.093e-111 Identity = 229/597 (38.36%), Postives = 353/597 (59.13%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERT---EIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERST---SDWWQLHSHKEFDCLSRNPFSPDKT--KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M +N + + A+ F++++E +D+T+ + S S+W+I+PP+K + LLD + ++ +RN S ++ D ++T + IA T K V ++ + + V +D + L SEN+ + I+LS + +T S+WW L + ++P+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2116 LEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDI---TIILSRDNTTKYNSEWWVL------NLTGNRIYNPNSQALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2701 HSP 2 Score: 130.183 bits (326), Expect = 3.391e-29 Identity = 99/342 (28.95%), Postives = 163/342 (47.66%), Query Frame = 2
Query: 641 SVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLS----------VSSQIDRARSSVIFE----------------------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
SV ++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + + + + K L + + KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 440 SVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 767 HSP 3 Score: 128.642 bits (322), Expect = 1.100e-28 Identity = 66/149 (44.30%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM+S +M++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F +V + KD P+ P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1843 DELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVE-VNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 1990 HSP 4 Score: 122.094 bits (305), Expect = 9.721e-27 Identity = 91/320 (28.44%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI +++ S CWLI + C T + + + + C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L G+ ++ EED D+R D
Sbjct: 1162 WLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNS-CWLIQAFSLAC--TVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEED--DEREAD 1475
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 399.438 bits (1025), Expect = 2.123e-111 Identity = 229/597 (38.36%), Postives = 353/597 (59.13%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERT---EIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERST---SDWWQLHSHKEFDCLSRNPFSPDKT--KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M +N + + A+ F++++E +D+T+ + S S+W+I+PP+K + LLD + ++ +RN S ++ D ++T + IA T K V ++ + + V +D + L SEN+ + I+LS + +T S+WW L + ++P+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2190 LEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDI---TIILSRDNTTKYNSEWWVL------NLTGNRIYNPNSQALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2775 HSP 2 Score: 130.568 bits (327), Expect = 3.062e-29 Identity = 99/342 (28.95%), Postives = 163/342 (47.66%), Query Frame = 2
Query: 641 SVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLS----------VSSQIDRARSSVIFE----------------------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
SV ++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + + + + K L + + KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 491 SVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 818 HSP 3 Score: 128.642 bits (322), Expect = 1.098e-28 Identity = 66/149 (44.30%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM+S +M++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F +V + KD P+ P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1917 DELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVE-VNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2064 HSP 4 Score: 122.094 bits (305), Expect = 9.952e-27 Identity = 91/320 (28.44%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI +++ S CWLI + C T + + + + C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L G+ ++ EED D+R D
Sbjct: 1236 WLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNS-CWLIQAFSLAC--TVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEED--DEREAD 1549
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 399.438 bits (1025), Expect = 2.182e-111 Identity = 229/597 (38.36%), Postives = 353/597 (59.13%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERT---EIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERST---SDWWQLHSHKEFDCLSRNPFSPDKT--KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M +N + + A+ F++++E +D+T+ + S S+W+I+PP+K + LLD + ++ +RN S ++ D ++T + IA T K V ++ + + V +D + L SEN+ + I+LS + +T S+WW L + ++P+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2165 LEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDI---TIILSRDNTTKYNSEWWVL------NLTGNRIYNPNSQALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2750 HSP 2 Score: 130.568 bits (327), Expect = 3.080e-29 Identity = 99/342 (28.95%), Postives = 163/342 (47.66%), Query Frame = 2
Query: 641 SVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLS----------VSSQIDRARSSVIFE----------------------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
SV ++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + + + + K L + + KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 491 SVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 818 HSP 3 Score: 128.642 bits (322), Expect = 1.042e-28 Identity = 66/149 (44.30%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM+S +M++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F +V + KD P+ P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1892 DELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVE-VNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2039 HSP 4 Score: 122.094 bits (305), Expect = 9.363e-27 Identity = 91/320 (28.44%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI +++ S CWLI + C T + + + + C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L G+ ++ EED D+R D
Sbjct: 1211 WLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNS-CWLIQAFSLAC--TVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEED--DEREAD 1524
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO1 (piezo type mechanosensitive ion channel component 1 [Source:HGNC Symbol;Acc:HGNC:28993]) HSP 1 Score: 345.51 bits (885), Expect = 7.791e-95 Identity = 218/593 (36.76%), Postives = 338/593 (57.00%), Query Frame = 3
Query: 4587 VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSL----TERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTS-----DWWQLHSHK-EFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
+++F+ ++ +Y DVY MF+ + + F II+ G+ AFG + +T L D ++P F++ML+ QF +++DRAL+LRK V+GKL FQ+ V+ IH+W+FF+ P ++ +N + Q YF KC+YFALS+YQI+ GYP RILGNFLTKKYN+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL WM VED++A IF++KC R +E +YP P+G + + KY +GGL+++F W PL+ S++ S+ V N P +TL+ G+ ++ +++ + + Y + + +A+ F+ + P+D+ I S ++W I+PP++ + L + + L +R D TV L+L T R ++ASL +V++ L P+++ A + + N I L E+ +WW + + DC + IFS+++S G + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE + LEE+L AKLIF+YRS ETMI++TR K+
Sbjct: 1942 LRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDIT-SSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQR---DLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDC--------NLLPMVIFSDKVSPPSLG-FLAGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2521 HSP 2 Score: 172.94 bits (437), Expect = 3.511e-42 Identity = 103/297 (34.68%), Postives = 165/297 (55.56%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLC----AKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++ SY+ + IAMM WS+TY SWLTFVLL+ AC++W + ++ SP I+ YG+ L + YV + ++ + P + + G+ + P + L + Y + FWL LR ++KEK+ S +V + + ++L+ L +L AKYWI+ C ++VS ++ + +VYM ++ +T F YS WR+ + +WWLV+ Y++ VL +YTFQF+ F W N T FT E L D G E F +S L +L P L+ I+Q+HYFH PFM+++D+
Sbjct: 419 IMDQSYVCALIAMMVWSITYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGMTLCCLRYVWAM---DLRPELPTTLGP-VSLRQLGLEHTRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESPAALTEVTVADTEPTRTQTLLQSLGELVKGVYAKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYSLWRKLLKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTGFTDEQLGDLGLEQFSVSELFSSILVPGFFLLACILQLHYFHRPFMQLTDM 711 HSP 3 Score: 107.842 bits (268), Expect = 2.245e-22 Identity = 59/145 (40.69%), Postives = 90/145 (62.07%), Query Frame = 3
Query: 4059 SSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALE-KDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDK 4490
R L+ A+ V +S++LCY I+++NHM++ + SL+ P+ VFLWAMLS PRPS +W+ I++T++ +++KY+FQF F S V ++ P+F P LG+ KT+ Y DL+QL LF HR L +GLW +D
Sbjct: 1668 GQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLWDHEEDS 1812 HSP 4 Score: 91.2781 bits (225), Expect = 2.515e-17 Identity = 96/374 (25.67%), Postives = 161/374 (43.05%), Query Frame = 3
Query: 2241 PKLCI--L*NGSRVYPFHFPYLLEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGEN----RPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHC----------IPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRI--EQTHQNYGR------------------PLPN-----------------EHYLVLRSGDYFLF 3200
P LCI SR P + L WL+LP + P + LI D + +C + Q+ VF E ++ G N P+ P +FI + SY+D LK +F + +WL L +VF G R ++F LGY++ G + + L W+ ++ YN +I+ K L L++CV+++ + CW+I + + C + R+ + +E + WD +CF FL++QR++F + + +V D++ T SRG L N + + + E + ++K ++ RI +Q GR P P+ +H V+ SGDYFLF
Sbjct: 1061 PALCIDYPWRWSRAVPMN--SALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPV---PNFIHCR-SYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALLQRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQ-MQTGFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPVEEA------GIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKHRQGRVDRSRPQDTLGPKDPGLEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLF 1421
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 251.521 bits (641), Expect = 5.047e-66 Identity = 114/222 (51.35%), Postives = 159/222 (71.62%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSE 5234
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE
Sbjct: 2165 LEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESE 2385 HSP 2 Score: 130.183 bits (326), Expect = 3.472e-29 Identity = 99/342 (28.95%), Postives = 163/342 (47.66%), Query Frame = 2
Query: 641 SVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLS----------VSSQIDRARSSVIFE----------------------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
SV ++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + + + + K L + + KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 491 SVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 818 HSP 3 Score: 128.642 bits (322), Expect = 1.018e-28 Identity = 66/149 (44.30%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM+S +M++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F +V + KD P+ P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1892 DELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVE-VNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2039 HSP 4 Score: 122.479 bits (306), Expect = 8.069e-27 Identity = 91/320 (28.44%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI +++ S CWLI + C T + + + + C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L G+ ++ EED D+R D
Sbjct: 1211 WLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNS-CWLIQAFSLAC--TVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEED--DEREAD 1524 HSP 5 Score: 113.235 bits (282), Expect = 5.545e-24 Identity = 94/310 (30.32%), Postives = 161/310 (51.94%), Query Frame = 3
Query: 5427 IYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERT---EIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERST---SDWWQLHSHKEFDCLSRNPFSPDKT--KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
I+ +++ L+ M +N + + A+ F++++E +D+T+ + S S+W+I+PP+K + LLD + ++ +RN S ++ D ++T + IA T K V ++ + + V +D + L SEN+ + I+LS + +T S+WW L + ++P+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2388 IFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDI---TIILSRDNTTKYNSEWWVL------NLTGNRIYNPNSQALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2687
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 410.994 bits (1055), Expect = 9.242e-117 Identity = 382/1489 (25.65%), Postives = 652/1489 (43.79%), Query Frame = 3
Query: 2277 YPFHF--PYLLEDWLFLPSYL--------NPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNE-----LPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQF-----ILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYI---DHIINYSK--CWLIHILGIHCIPTRENHI---------SISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL----------PNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLD---YMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKD-SPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK--GFKDKFNIKEPEKK--------------------TNFNTLQTSSLTSRFILLKPFIT-------------------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRG-------------DML----QAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECER--NPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-KGLPRFL-VATKTDFQDALVLGSE--NSLNPLESYMIMLSIERSTSDWW--------QLHSHKEFDCLSRNPFSPDK-TKFFI-----------------FSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
YP+ + P +D F SYL N P AY LIGD + + Q VF+ E GE+ ++N+ P+ DFI K SY+DY K +F + +W+TL GI +LF LGY+I W G L ++ L WN +L Y I +K LQ+ CV++ D + K C + + I C+ E H+ + ++E G+I +DV+ FL+ Q +IF + F + +++ + +RGA+L N+ + + E+ E++ F ++ R E + Y + + P + R+GDY++F+ YD DD E + F + D K + + LD M + D+ + + K I P +R+ L + + + ED KDS E +K+ +K + LD + +N L ++ RYV +L EK+ +K+ G E+ L+ T + V+L ++ + + + K+ ET+ + +Q+ SS LL A+ N + ++D+LCY +M +++ +++L PL W LS PRPS F+W+ +I YT+ VI+IK+V QF F+ S E P L G+++ + +AL D++ LF LF HR L+ GLWK D F +KE + T +TL+ +S I P + +F L ++ D+Y MF + I F I+ GY AFG G + LD +K S+IP+ ++ML+ + IIIDRAL+LRK V+GKL++Q+ + +H+W+F + P ++R + Q LY K YF +S++QI++GYP +GN LT Y N+ FK ++ +PFL+ELR +DW WTDT++ L+ + +E+ +A IF +KC R+ E YP PRG + + KY++G ++I + + PL+L S++ I + P L + +G+ +YE ++G D L QA++D + + +++S++K + +D+ I+ SE W I+ +++ + L + ++N +E R +P++ K + +L +T R +I S + +L+ + +P F+ V + + +G+ N NP + M + + + W+ Q S E ++ + D+ K +I F +R + ++F I + + V L+R +++ + ELP D +LK+ +IYLVRE K F LE+ L AKLIF++RS T+I +TR+ +
Sbjct: 334 YPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAY-LIGDFFVLLLASCQLAVFRRE--------GEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCV-NNECHVLKELEDFSKACAVETKEGNIG----FDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRR---RTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFK-------YDPENDDLVEPVDSFVPEVDP--KATAYDRLDPGQIMYAATAHDLDLAKT--------VQQVKKGDTIKDPDSRA-------------------------LIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQK----------MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS-----------GHSES---------------------LSNTSRKLTDIRSAVDLPSLQLVQSANDVEKM----------------ETAVSVDWQQKSSATRLL-NAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFG--EGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDK-LSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARA-WFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1700
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 410.994 bits (1055), Expect = 9.242e-117 Identity = 382/1489 (25.65%), Postives = 652/1489 (43.79%), Query Frame = 3
Query: 2277 YPFHF--PYLLEDWLFLPSYL--------NPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNE-----LPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQF-----ILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYI---DHIINYSK--CWLIHILGIHCIPTRENHI---------SISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL----------PNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLD---YMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKD-SPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK--GFKDKFNIKEPEKK--------------------TNFNTLQTSSLTSRFILLKPFIT-------------------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRG-------------DML----QAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECER--NPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-KGLPRFL-VATKTDFQDALVLGSE--NSLNPLESYMIMLSIERSTSDWW--------QLHSHKEFDCLSRNPFSPDK-TKFFI-----------------FSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
YP+ + P +D F SYL N P AY LIGD + + Q VF+ E GE+ ++N+ P+ DFI K SY+DY K +F + +W+TL GI +LF LGY+I W G L ++ L WN +L Y I +K LQ+ CV++ D + K C + + I C+ E H+ + ++E G+I +DV+ FL+ Q +IF + F + +++ + +RGA+L N+ + + E+ E++ F ++ R E + Y + + P + R+GDY++F+ YD DD E + F + D K + + LD M + D+ + + K I P +R+ L + + + ED KDS E +K+ +K + LD + +N L ++ RYV +L EK+ +K+ G E+ L+ T + V+L ++ + + + K+ ET+ + +Q+ SS LL A+ N + ++D+LCY +M +++ +++L PL W LS PRPS F+W+ +I YT+ VI+IK+V QF F+ S E P L G+++ + +AL D++ LF LF HR L+ GLWK D F +KE + T +TL+ +S I P + +F L ++ D+Y MF + I F I+ GY AFG G + LD +K S+IP+ ++ML+ + IIIDRAL+LRK V+GKL++Q+ + +H+W+F + P ++R + Q LY K YF +S++QI++GYP +GN LT Y N+ FK ++ +PFL+ELR +DW WTDT++ L+ + +E+ +A IF +KC R+ E YP PRG + + KY++G ++I + + PL+L S++ I + P L + +G+ +YE ++G D L QA++D + + +++S++K + +D+ I+ SE W I+ +++ + L + ++N +E R +P++ K + +L +T R +I S + +L+ + +P F+ V + + +G+ N NP + M + + + W+ Q S E ++ + D+ K +I F +R + ++F I + + V L+R +++ + ELP D +LK+ +IYLVRE K F LE+ L AKLIF++RS T+I +TR+ +
Sbjct: 334 YPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAY-LIGDFFVLLLASCQLAVFRRE--------GEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCV-NNECHVLKELEDFSKACAVETKEGNIG----FDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRR---RTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFK-------YDPENDDLVEPVDSFVPEVDP--KATAYDRLDPGQIMYAATAHDLDLAKT--------VQQVKKGDTIKDPDSRA-------------------------LIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQK----------MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS-----------GHSES---------------------LSNTSRKLTDIRSAVDLPSLQLVQSANDVEKM----------------ETAVSVDWQQKSSATRLL-NAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFG--EGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDK-LSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARA-WFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1700
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 410.609 bits (1054), Expect = 1.309e-116 Identity = 382/1489 (25.65%), Postives = 652/1489 (43.79%), Query Frame = 3
Query: 2277 YPFHF--PYLLEDWLFLPSYL--------NPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNE-----LPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQF-----ILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYI---DHIINYSK--CWLIHILGIHCIPTRENHI---------SISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL----------PNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLD---YMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKD-SPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK--GFKDKFNIKEPEKK--------------------TNFNTLQTSSLTSRFILLKPFIT-------------------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRG-------------DML----QAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECER--NPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-KGLPRFL-VATKTDFQDALVLGSE--NSLNPLESYMIMLSIERSTSDWW--------QLHSHKEFDCLSRNPFSPDK-TKFFI-----------------FSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
YP+ + P +D F SYL N P AY LIGD + + Q VF+ E GE+ ++N+ P+ DFI K SY+DY K +F + +W+TL GI +LF LGY+I W G L ++ L WN +L Y I +K LQ+ CV++ D + K C + + I C+ E H+ + ++E G+I +DV+ FL+ Q +IF + F + +++ + +RGA+L N+ + + E+ E++ F ++ R E + Y + + P + R+GDY++F+ YD DD E + F + D K + + LD M + D+ + + K I P +R+ L + + + ED KDS E +K+ +K + LD + +N L ++ RYV +L EK+ +K+ G E+ L+ T + V+L ++ + + + K+ ET+ + +Q+ SS LL A+ N + ++D+LCY +M +++ +++L PL W LS PRPS F+W+ +I YT+ VI+IK+V QF F+ S E P L G+++ + +AL D++ LF LF HR L+ GLWK D F +KE + T +TL+ +S I P + +F L ++ D+Y MF + I F I+ GY AFG G + LD +K S+IP+ ++ML+ + IIIDRAL+LRK V+GKL++Q+ + +H+W+F + P ++R + Q LY K YF +S++QI++GYP +GN LT Y N+ FK ++ +PFL+ELR +DW WTDT++ L+ + +E+ +A IF +KC R+ E YP PRG + + KY++G ++I + + PL+L S++ I + P L + +G+ +YE ++G D L QA++D + + +++S++K + +D+ I+ SE W I+ +++ + L + ++N +E R +P++ K + +L +T R +I S + +L+ + +P F+ V + + +G+ N NP + M + + + W+ Q S E ++ + D+ K +I F +R + ++F I + + V L+R +++ + ELP D +LK+ +IYLVRE K F LE+ L AKLIF++RS T+I +TR+ +
Sbjct: 316 YPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAY-LIGDFFVLLLASCQLAVFRRE--------GEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCV-NNECHVLKELEDFSKACAVETKEGNIG----FDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRR---RTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFK-------YDPENDDLVEPVDSFVPEVDP--KATAYDRLDPGQIMYAATAHDLDLAKT--------VQQVKKGDTIKDPDSRA-------------------------LIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQK----------MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS-----------GHSES---------------------LSNTSRKLTDIRSAVDLPSLQLVQSANDVEKM----------------ETAVSVDWQQKSSATRLL-NAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFG--EGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDK-LSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARA-WFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1682
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 409.838 bits (1052), Expect = 3.596e-115 Identity = 382/1489 (25.65%), Postives = 652/1489 (43.79%), Query Frame = 3
Query: 2277 YPFHF--PYLLEDWLFLPSYL--------NPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNE-----LPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQF-----ILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYI---DHIINYSK--CWLIHILGIHCIPTRENHI---------SISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL----------PNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLD---YMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKD-SPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK--GFKDKFNIKEPEKK--------------------TNFNTLQTSSLTSRFILLKPFIT-------------------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRG-------------DML----QAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECER--NPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-KGLPRFL-VATKTDFQDALVLGSE--NSLNPLESYMIMLSIERSTSDWW--------QLHSHKEFDCLSRNPFSPDK-TKFFI-----------------FSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
YP+ + P +D F SYL N P AY LIGD + + Q VF+ E GE+ ++N+ P+ DFI K SY+DY K +F + +W+TL GI +LF LGY+I W G L ++ L WN +L Y I +K LQ+ CV++ D + K C + + I C+ E H+ + ++E G+I +DV+ FL+ Q +IF + F + +++ + +RGA+L N+ + + E+ E++ F ++ R E + Y + + P + R+GDY++F+ YD DD E + F + D K + + LD M + D+ + + K I P +R+ L + + + ED KDS E +K+ +K + LD + +N L ++ RYV +L EK+ +K+ G E+ L+ T + V+L ++ + + + K+ ET+ + +Q+ SS LL A+ N + ++D+LCY +M +++ +++L PL W LS PRPS F+W+ +I YT+ VI+IK+V QF F+ S E P L G+++ + +AL D++ LF LF HR L+ GLWK D F +KE + T +TL+ +S I P + +F L ++ D+Y MF + I F I+ GY AFG G + LD +K S+IP+ ++ML+ + IIIDRAL+LRK V+GKL++Q+ + +H+W+F + P ++R + Q LY K YF +S++QI++GYP +GN LT Y N+ FK ++ +PFL+ELR +DW WTDT++ L+ + +E+ +A IF +KC R+ E YP PRG + + KY++G ++I + + PL+L S++ I + P L + +G+ +YE ++G D L QA++D + + +++S++K + +D+ I+ SE W I+ +++ + L + ++N +E R +P++ K + +L +T R +I S + +L+ + +P F+ V + + +G+ N NP + M + + + W+ Q S E ++ + D+ K +I F +R + ++F I + + V L+R +++ + ELP D +LK+ +IYLVRE K F LE+ L AKLIF++RS T+I +TR+ +
Sbjct: 1072 YPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAY-LIGDFFVLLLASCQLAVFRRE--------GEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCV-NNECHVLKELEDFSKACAVETKEGNIG----FDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRR---RTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFK-------YDPENDDLVEPVDSFVPEVDP--KATAYDRLDPGQIMYAATAHDLDLAKTV--------QQVKKGDTIKDPDSRA-------------------------LIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQK----------MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS-----------GHSES---------------------LSNTSRKLTDIRSAVDLPSLQLVQSANDVEKM----------------ETAVSVDWQQKSSATRLL-NAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFG--EGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDK-LSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARA-WFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 2438 HSP 2 Score: 58.9214 bits (141), Expect = 5.426e-8 Identity = 92/363 (25.34%), Postives = 162/363 (44.63%), Query Frame = 2
Query: 557 KKNRFTEHIHNTETTATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNIN-----GDEI-MNTIKIFFEPYFEISEFGIFEWKI----PFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRAR-----------------SSVIFED--NSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVF----DMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR 1546
+N+ + +I NT A S I +V+T ++ +SY + AMM W++ Y S +LLIL CILW+ D+R + M+P I+ Y L+ + Y +++ GD MN + I EW I L + + +L LRL +EK S+S + R + F+D + F + V +L + Y+IF ++ LL+VS +++ + + + FS+ +R Y +W + Y+ V+ +Y +QF + T +QE L G F + +L LL+P+ L +VT++Q+ +FH P+ + + +P+R
Sbjct: 431 DRNKLS-NIFNTTAPGDKESAASKGMI-AVMTFVIFHSYSIALTAMMTWALLYHSIFGLILLILTCILWIFRDTRKSSFAMAPIILMYIEFLLILQYFLSMDIHAEIGDPAWMNFVGI--------------EWTTLPVHAVIILCVQTLLTLPVFLLLRLARREKFYESLSDYERQRRINSYGTFGASKTGAGGVAVAKFQDPKSRKFAAFVEYLSNKVSVYFIFVVSVVLLVVSTCFAPNFYNILFFALWALNLIYLKFSFRLYRGLAYAFWLTLTFYTSIVIIALYIYQFPGVSQWIIRNTSLSQEWLNAIGLVDFRAIGESGALFLQLLAPIALFVVTMLQLKFFHGPWSRAT--SPRR 775
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 409.838 bits (1052), Expect = 3.958e-115 Identity = 382/1489 (25.65%), Postives = 652/1489 (43.79%), Query Frame = 3
Query: 2277 YPFHF--PYLLEDWLFLPSYL--------NPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNE-----LPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQF-----ILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYI---DHIINYSK--CWLIHILGIHCIPTRENHI---------SISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL----------PNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLD---YMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKD-SPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK--GFKDKFNIKEPEKK--------------------TNFNTLQTSSLTSRFILLKPFIT-------------------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRG-------------DML----QAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECER--NPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-KGLPRFL-VATKTDFQDALVLGSE--NSLNPLESYMIMLSIERSTSDWW--------QLHSHKEFDCLSRNPFSPDK-TKFFI-----------------FSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
YP+ + P +D F SYL N P AY LIGD + + Q VF+ E GE+ ++N+ P+ DFI K SY+DY K +F + +W+TL GI +LF LGY+I W G L ++ L WN +L Y I +K LQ+ CV++ D + K C + + I C+ E H+ + ++E G+I +DV+ FL+ Q +IF + F + +++ + +RGA+L N+ + + E+ E++ F ++ R E + Y + + P + R+GDY++F+ YD DD E + F + D K + + LD M + D+ + + K I P +R+ L + + + ED KDS E +K+ +K + LD + +N L ++ RYV +L EK+ +K+ G E+ L+ T + V+L ++ + + + K+ ET+ + +Q+ SS LL A+ N + ++D+LCY +M +++ +++L PL W LS PRPS F+W+ +I YT+ VI+IK+V QF F+ S E P L G+++ + +AL D++ LF LF HR L+ GLWK D F +KE + T +TL+ +S I P + +F L ++ D+Y MF + I F I+ GY AFG G + LD +K S+IP+ ++ML+ + IIIDRAL+LRK V+GKL++Q+ + +H+W+F + P ++R + Q LY K YF +S++QI++GYP +GN LT Y N+ FK ++ +PFL+ELR +DW WTDT++ L+ + +E+ +A IF +KC R+ E YP PRG + + KY++G ++I + + PL+L S++ I + P L + +G+ +YE ++G D L QA++D + + +++S++K + +D+ I+ SE W I+ +++ + L + ++N +E R +P++ K + +L +T R +I S + +L+ + +P F+ V + + +G+ N NP + M + + + W+ Q S E ++ + D+ K +I F +R + ++F I + + V L+R +++ + ELP D +LK+ +IYLVRE K F LE+ L AKLIF++RS T+I +TR+ +
Sbjct: 1030 YPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAY-LIGDFFVLLLASCQLAVFRRE--------GEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCV-NNECHVLKELEDFSKACAVETKEGNIG----FDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRR---RTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMFK-------YDPENDDLVEPVDSFVPEVDP--KATAYDRLDPGQIMYAATAHDLDLAKTV--------QQVKKGDTIKDPDSRA-------------------------LIAVSEPEARKPGGTEETDGDEDEDNKDSKVESTAKFIQK----------MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKS-----------GHSES---------------------LSNTSRKLTDIRSAVDLPSLQLVQSANDVEKM----------------ETAVSVDWQQKSSATRLL-NAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFG--EGGSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDK-LSRNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARA-WFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKGGVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 2396 HSP 2 Score: 60.8474 bits (146), Expect = 1.536e-8 Identity = 122/503 (24.25%), Postives = 200/503 (39.76%), Query Frame = 2
Query: 299 VLYMYQIGI------------TKLLGLYYKIDTSCERHGSVTILQQRFFD---------FMNPFALFALFYIHSLDSKIWLD--REAIQN--------LALFTKSSSSQNTNAAVSQKKNRFTEHIHNTE-------------------------TTATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNIN-----GDEI-MNTIKIFFEPYFEISEFGIFEWKI----PFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSS--QIDRARSSVIFEDNST---------------FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVF----DMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR 1546
VLY YQI I +L GL +D+SC + F D + NP + FY+ K + RE I + L + +SSS N + Q + R + N E T A S I +V+T ++ +SY + AMM W++ Y S +LLIL CILW+ D+R + M+P I+ Y L+ + Y +++ GD MN + I EW I L + + +L LRL +EK S+S + R S F + T F + V +L + Y+IF ++ LL+VS +++ + + + FS+ +R Y +W + Y+ V+ +Y +QF + T +QE L G F + +L LL+P+ L +VT++Q+ +FH P+ + + +P+R
Sbjct: 251 VLYTYQIPIVHHSWLPTGSFLPRLFGLTVLMDSSCPEWWKFPFVAPDFNDDDLIMKWPLYANPIVVLVFFYLTVAQYKFTRNGSREYIDDNEYGSSVHEELLSNASSSANDD---EQGRARSRSPLRNGEEQGSIPLRKVTSQVVDRNKLSNIFNTPGDKESAASKGMI-AVMTFVIFHSYSIALTAMMTWALLYHSIFGLILLILTCILWIFRDTRKSSFAMAPIILMYIEFLLILQYFLSMDIHAEIGDPAWMNFVGI--------------EWTTLPVHAVIILCVQTLLTLPVFLLLRLARREKFYESLSDYERQRRINSYGTFGASKTGAGGVAVAKDPKSRKFAAFVEYLSNKVSVYFIFVVSVVLLVVSTCFAPNFYNILFFALWALNLIYLKFSFRLYRGLAYAFWLTLTFYTSIVIIALYIYQFPGVSQWIIRNTSLSQEWLNAIGLVDFRAIGESGALFLQLLAPIALFVVTMLQLKFFHGPWSRAT--SPRR 733
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335175) HSP 1 Score: 416.772 bits (1070), Expect = 4.737e-117 Identity = 271/896 (30.25%), Postives = 471/896 (52.57%), Query Frame = 3
Query: 3891 QTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
Q H + ++EL V + I++ P +E Q+ + ++++ ++ +D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1815 QQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFA----QRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2687 HSP 2 Score: 157.918 bits (398), Expect = 6.818e-38 Identity = 116/398 (29.15%), Postives = 181/398 (45.48%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQ-------------NYGRPLPNE----------HYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRN 3365
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q +G PLP H R+GDY++FEE ++ E D I D +FL+ ++ ++K + + L Y + ++D +++R+
Sbjct: 1137 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFEL-DLIHDEIDFLEE-ENITESEMKMQRRKTL-YDVWKDLNDAEYRRH 1529 HSP 3 Score: 137.502 bits (345), Expect = 1.055e-31 Identity = 112/377 (29.71%), Postives = 182/377 (48.28%), Query Frame = 2
Query: 461 DSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEIS-EFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFM 1519
+ ++ L R++ + S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ +I E I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+
Sbjct: 419 NQRLSLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFI 794
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335182) HSP 1 Score: 416.387 bits (1069), Expect = 4.969e-117 Identity = 271/896 (30.25%), Postives = 471/896 (52.57%), Query Frame = 3
Query: 3891 QTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
Q H + ++EL V + I++ P +E Q+ + ++++ ++ +D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1657 QQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFA----QRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2529 HSP 2 Score: 166.007 bits (419), Expect = 2.328e-40 Identity = 110/342 (32.16%), Postives = 163/342 (47.66%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNE-HYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLK 3263
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q RPL + H+ R+GDY++FEE ++ E D I D +FL+
Sbjct: 1085 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDATRAGDYYMFEEMDDKFEL-DLIHDEIDFLE 1423 HSP 3 Score: 147.902 bits (372), Expect = 7.908e-35 Identity = 131/458 (28.60%), Postives = 211/458 (46.07%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFF--DFMNPFALF------ALFYIHSLDSKIWLDREAIQNLALFTKSS-----------------SSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEISEFGIFEWKI-----PFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTP 1540
+L+GL I++ C V + + ++NPFALF AL H + ++ L R+ L T+++ S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ + + G FE I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+ P
Sbjct: 294 ARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRVSLRRDQRATLNEPTETTPLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPYLQTAGINLQQIG-FERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQP 749
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0347414) HSP 1 Score: 416.772 bits (1070), Expect = 5.080e-117 Identity = 271/896 (30.25%), Postives = 471/896 (52.57%), Query Frame = 3
Query: 3891 QTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
Q H + ++EL V + I++ P +E Q+ + ++++ ++ +D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1944 QQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFA----QRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2816 HSP 2 Score: 146.362 bits (368), Expect = 2.049e-34 Identity = 126/428 (29.44%), Postives = 205/428 (47.90%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFF--DFMNPFALFALFYIHSLDSK----IWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEIS-EFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFM 1519
+L+GL I++ C V + + ++NPFALF ++ +L +K L R++ + S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ +I E I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+
Sbjct: 294 ARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFI 720 HSP 3 Score: 145.206 bits (365), Expect = 5.297e-34 Identity = 99/321 (30.84%), Postives = 145/321 (45.17%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPL-----------PNEHYL 3170
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q RPL P+EH +
Sbjct: 1063 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDGRRTPSEHAM 1381
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335176) HSP 1 Score: 416.387 bits (1069), Expect = 5.421e-117 Identity = 262/821 (31.91%), Postives = 447/821 (54.45%), Query Frame = 3
Query: 4116 SDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
+D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1848 TDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2649 HSP 2 Score: 157.918 bits (398), Expect = 6.183e-38 Identity = 116/398 (29.15%), Postives = 181/398 (45.48%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQ-------------NYGRPLPNE----------HYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRN 3365
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q +G PLP H R+GDY++FEE ++ E D I D +FL+ ++ ++K + + L Y + ++D +++R+
Sbjct: 1137 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFEL-DLIHDEIDFLEE-ENITESEMKMQRRKTL-YDVWKDLNDAEYRRH 1529 HSP 3 Score: 137.887 bits (346), Expect = 8.299e-32 Identity = 113/384 (29.43%), Postives = 183/384 (47.66%), Query Frame = 2
Query: 461 DSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEIS-EFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTP 1540
+ ++ L R++ + S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ +I E I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+ P
Sbjct: 419 NQRLSLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQP 801
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335179) HSP 1 Score: 416.001 bits (1068), Expect = 6.328e-117 Identity = 271/896 (30.25%), Postives = 471/896 (52.57%), Query Frame = 3
Query: 3891 QTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
Q H + ++EL V + I++ P +E Q+ + ++++ ++ +D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1657 QQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFA----QRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2529 HSP 2 Score: 156.377 bits (394), Expect = 2.184e-37 Identity = 111/364 (30.49%), Postives = 163/364 (44.78%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQ-------------NYGRPLPNE----------HYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLK 3263
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q +G PLP H R+GDY++FEE ++ E D I D +FL+
Sbjct: 1063 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFEL-DLIHDEIDFLE 1423 HSP 3 Score: 147.517 bits (371), Expect = 9.760e-35 Identity = 127/435 (29.20%), Postives = 206/435 (47.36%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFF--DFMNPFALFALFYIHSLDSK----IWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEIS-EFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTP 1540
+L+GL I++ C V + + ++NPFALF ++ +L +K L R++ + S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ +I E I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+ P
Sbjct: 294 ARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQP 727
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 392.119 bits (1006), Expect = 3.057e-116 Identity = 225/602 (37.38%), Postives = 348/602 (57.81%), Query Frame = 3
Query: 4566 LLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESY-------MIMLSIERSTS------DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
+L +I +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ +++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNYLNLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ + L+ +++ ++ + Y A+ F++++ +DVT+ + S S+W+I+PP++ M +L K+ + +RN S V L + R E+ +L + VL++ + P F+ A S+++ P+E I L +ERS + +WW + + R + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 265 VLDVYIPIRQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLM-DVLSKEDQFPVTMTWSIQRNLS-LGAKSEFAMDKHVTYLDIKTRQELIALLNGTRNTPVLIEQVFPCFIRAP-----------SDSNAKPIEQLYEDGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQKQQREA----GLQLYVFSDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 847 HSP 2 Score: 110.538 bits (275), Expect = 9.716e-24 Identity = 61/145 (42.07%), Postives = 97/145 (66.90%), Query Frame = 3
Query: 4038 QAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
Q+++F +S +L L ++ N+++ +S M+CY+++++NHMIS ++ +L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F + ++K PF P +G+ K E Y DL+QL LF HR LK +GLW
Sbjct: 9 QSERFYRSQPQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIE-VDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLW 152
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: LO018508.1 (pep chromosome:GRCz11:2:54327160:54353625:1 gene:ENSDARG00000112723.1 transcript:ENSDART00000182320.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:LO018508.1) HSP 1 Score: 378.252 bits (970), Expect = 1.939e-114 Identity = 231/602 (38.37%), Postives = 341/602 (56.64%), Query Frame = 3
Query: 4587 VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLV-----KGLPRFL------VATKTDFQDALVLGSENSLNPLES----YM-IMLSIERSTS-----DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
+++F+ NL YS DVYV MF+ + + F IIV G+ AFG G L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P I+ +++ Q YF KC+YF LS+YQI+ GYP RILGNFLTK YNY NLFLF+G+ L+PFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P ++L G I+ ++ + N+IK N A+ F++S+ P+D+TI ++ S S+W+I+PP+K+ NL +M+ R P ++ +NLSL + E A KY + + KGL L V K F + S+++ P++ YM I L + + S +WW ++ + D + + +I S+++S G + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 26 IRQFFYNLVHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHQGGADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVVGKVIFQVILVFGIHFWMFFILPGITERRFSQNTIAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKSYNYANLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLEVSVSLTLGGLQPIFTMSA-----------QQNHIKSVTGN---AIMFLESYFPEDLTIAHLEGSSNSLWTISPPSKE-------------NLKNMLNDTREP-----FPLTFTWSIQRNLSLGAKAETAM-----GKYFIELDDETRKGLTDQLGNSSQRVTIKKIFPRYIRAPSDSNAKPIDQLYNEYMDITLFLNKKNSSEGVQEWWIVN---QTDSGPLPGLNGSGLQIYIISDQVSPPSLG-FLAGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTREK 585
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 390.578 bits (1002), Expect = 7.984e-109 Identity = 225/602 (37.38%), Postives = 348/602 (57.81%), Query Frame = 3
Query: 4566 LLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESY-------MIMLSIERSTS------DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
+L +I +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ +++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNYLNLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ + L+ +++ ++ + Y A+ F++++ +DVT+ + S S+W+I+PP++ M +L K+ + +RN S V L + R E+ +L + VL++ + P F+ A S+++ P+E I L +ERS + +WW + + R + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2038 VLDVYIPIRQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLM-DVLSKEDQFPVTMTWSIQRNLS-LGAKSEFAMDKHVTYLDIKTRQELIALLNGTRNTPVLIEQVFPCFIRAP-----------SDSNAKPIEQLYEDGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQKQQREA----GLQLYVFSDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2620 HSP 2 Score: 128.642 bits (322), Expect = 6.600e-29 Identity = 96/302 (31.79%), Postives = 156/302 (51.66%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVS----SQIDRARSSVIFEDNST-----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFV LI +C LW++ D R +V SPF+V YG +LI + Y+ + E + + F + ++PF L L+ FWL LR ++ E+ S + + +D + + L L + KYWI+ C VS + ++ + ++YMM + + + Y WR + +W V+VY++ VL +YTFQF+ +W N T ++E L+D G E F + +L + P L+V I+ +HYFH F++++D+
Sbjct: 398 IMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYSMVTSPFMVFYGNLLIILQYIWSF---ECLQPVPGLF-----------LKKEVPFRELGSKTLCLLSFWLLLRQFLTERREKHTDDPQLSDVTVDGHKLGLQDEAAGHREMMEVLGSSLMAMLNKYWIYICGGMFFFVSFEGRIVMYKIIYMMMFLFCVALYQLHYERWRWMLKYFWMSVVVYTMLVLILVYTFQFESSINVWSNMTGMSREKLEDLGLEKFSVPALFTRIFIPTWFLLVCILHLHYFHERFLELTDI 685 HSP 3 Score: 122.479 bits (306), Expect = 5.689e-27 Identity = 82/301 (27.24%), Postives = 148/301 (49.17%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN-NIYKYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGD 3188
WL+ P + P + L+ D + +C +LQ VF+ E + + G+N I + T + DFI + SY+D LK ++F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L + +C YI ++ + CWLI + + C + C +++ WD +CF FL++QR++F + F +VV D++ + SRGA L ++ + E+E + +K ++ RI+ Q + R L SG+
Sbjct: 1087 WLYFPDFHTKPNSLFLLYDFMLLLCASLQGRVFEEECVSPVQLLAGDNVEICRDLDAATFSQHNPVPDFIHCR-SYLDMLKVMVFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLIFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKALVA-NHCWLIQLFSLACTIKGYSKPEQQANKQCELPSDEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRSSQLLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQKFKRGKERMLSLAQESGE 1385 HSP 4 Score: 110.538 bits (275), Expect = 2.345e-23 Identity = 61/145 (42.07%), Postives = 97/145 (66.90%), Query Frame = 3
Query: 4038 QAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
Q+++F +S +L L ++ N+++ +S M+CY+++++NHMIS ++ +L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F + ++K PF P +G+ K E Y DL+QL LF HR LK +GLW
Sbjct: 1782 QSERFYRSQPQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIE-VDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLW 1925
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 362.844 bits (930), Expect = 2.271e-100 Identity = 224/588 (38.10%), Postives = 341/588 (57.99%), Query Frame = 3
Query: 4596 FYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTE----RTEIASLFTIPKKYAVLVKGL-PRFLVA-TKTDFQDALVL--GSENSLNPLE-SYMIMLSIERSTS-DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
F+ N+ Y DVY MF+ + + F II+ G+ AFG + + A L + ++P F++ML+ QF +IIDRAL+LRK ++GKL+FQ+ V IH+W+FF+ P ++ +N Q YFFKC+YF LS+YQI+ GYP RILGNFLTKK+N+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL +WM VED++A IF++KC R +E +YP P+G + + KY +GGL+++F W PL+ S++ S+ V N P +T++ G+ ++ + + +Q ++ YN + + + N VA+ F+ + +D+ I S S+W I+PP++ +K LL M L +R D TV + ++SL R ++ASL +K V V + P ++ A + + + + L G E + S M S+ + + +WW + DC P IF++++S G + YGI+G+Y + + V + +R +S IS+ I EELP DRILKL +I+LVRE LEE+L +KLIF+YRS ETMI++TR K
Sbjct: 1858 FFQNILHAEYRASTDVYALMFLTDVVDFIIIIFGFWAFGKHSAAADIA-SSLSEDQVPEAFLVMLLIQFSTMIIDRALYLRKSILGKLIFQVILVFGIHLWMFFILPAVTERMFNHNSVAQLWYFFKCIYFTLSAYQIRCGYPTRILGNFLTKKFNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKRIVKYGMGGLIILFLICIIWFPLLFISLVKSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTESRYNQLNNQFSKNAVAMQFITMYSYEDIVTANIEGSSGSVWRISPPSRQELIKELLSSTGDMTLRLDWNFQR---DLGKGGTVENTFDKHSISLAPKNPVRADLASLLLGTRKDPVHVPHMFPNYIRAPSGAEAKPVMQLFDGDEEGFQDVTVSLMREASVNTTGAQEWWDISIA---DCKESCNVLP----MIIFNDKVSPPSLG-FLAGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCADRILKLCMDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTREK 2433 HSP 2 Score: 148.288 bits (373), Expect = 6.390e-35 Identity = 127/403 (31.51%), Postives = 200/403 (49.63%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGD-EIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKE----KIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLH-HEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELNYLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIV 1846
+++ SYI + IAMM WS+TY SWLTFVLL+ +C++W+L + SPFI+ YG+ L + YV ++ + E+ I + + G+ + P + L + + + FWL LR +K+ K L+V Q + + S K + L AKYWI+ C ++VS ++ +VYM+ ++ M + YS WRR + +WW+V+ Y++ VL IYTFQF+ F W N+T FT++ L D G E F +S L ++ P L+ I+Q+HYFH PFMK++D LE + +H HE E +Q++Y D LV D + +L+RK ++ IWR+LE+H KI+
Sbjct: 408 VLQQSYICALIAMMVWSITYHSWLTFVLLLWSCVIWMLRTRQRFAAYCSPFILLYGLALCCLQYVWAMDLETELPQHIG-----SMSLHQLGLDRAQYPCLRLGALLLFTLTFWLLLRQSVKDTFSRKKSLTVPLQ-EVTTGESTGRNESILKVFGGLVMSLYAKYWIYVCGGMFIMVSFAGKLVAYKIVYMLLFLLCMCLYQVYYSLWRRLLKAFWWMVVAYTMVVLIAIYTFQFEDFPGYWGNFTGFTEQQLADMGLETFKLSELFTSIVIPGFFLLACILQLHYFHKPFMKITD------------LENVSPIHRHE----PEEEELIVDQDDYPSEA-------------DEVIPSKWGLVMD---RLMVLSRKFSDTLTHVQSFIWRVLELHIVKIVA 772 HSP 3 Score: 133.65 bits (335), Expect = 1.853e-30 Identity = 99/311 (31.83%), Postives = 163/311 (52.41%), Query Frame = 3
Query: 3660 YTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENI----------DVKLYYDKINKIDNEPHINNTNNVIF------VDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVN-ALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW---KGFKDKFNIKEPEKKTNFNT 4532
+ FL +D + +NLLTK +L E+ L + S EN +Q ++ L L +T+ VVE E + L + ++D EP + T + + VDE Q+++F S +RL L+ A+ N++ +S+++CY I+V+N++++ +++SL+ P+ VFLWAMLS PRPS +W+ I+YT++++++KY+FQF F ++ L +D PFF P LG+ KT++Y DLLQL VLF HR L+ +GLW ++K ++ E K N T
Sbjct: 1468 WVLFLAMVDGFTMWLNLLTKQYVDTSMVLSEERYLFIHNV------SQRASREN----MDDQISHDSEDLTLETCLDETDTDNICDTNVVESETLGGFAKSRDFSSTTLSSELTLELDCEPFYSQTASELLSERPFRVDELIQSREFYSSQNRLLKLLFALYNVLAAHSELVCYFIIVLNNLVTASVISLVLPVLVFLWAMLSVPRPSKRFWMTAIIYTEVMVVVKYLFQFGFFPWNTEYELKLNEDKPFFPPRILGLEKTDNYIRYDLLQLLVLFFHRSLLQRYGLWDQEGPLEEKSDLSPAENKPNTET 1768 HSP 4 Score: 120.553 bits (301), Expect = 1.888e-26 Identity = 95/352 (26.99%), Postives = 163/352 (46.31%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN-NIYKYKGGENRP-------IVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI--------PTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNY--GR------PLPNE-------------------HYLVLRSGDYFLFE-EHQEEDE 3224
L W++LP + P + LI D + MC + Q+ VF E + GGENR ++FN P +FI N SY+D K ++F + +W L +VF G R ++F LGY++ + G + + + L W+ ++ YN +I+ K L +++CV++ + + CW+I + + C S+ +E + WD +CF FL++QR++F + F +V D++ + + SRG L ++ + ++ E + ++KE + RI Q Y GR P+E H VL SG+Y++FE + EEDE
Sbjct: 1034 LVKWMYLPDFYTVPNSKNLISDFLLLMCASQQWTVFDNEKKEEWMVMGGENRDNPDPMENMLFNPAP-----NFI-NCRSYLDMAKILVFRYMFWFVLSVVFVTGATRISVFGLGYLMACFFFLLFGTKLLTKPSRTRLVMWDCLIIYNVAVIISKNILSILACVFVME-MQKNFCWVIQLFSLVCTVKGYYDPESVCNKDCSLPVEEA------GIIWDSICFFFLLLQRRVFLSFYFLHVSADLQASARQASRGFELFRASIIKNMHFHQQAERKSIQQLKESMKRIRGKQQKYKDGRITSDIEEQPSEQKKETKLSKSKSWQYPWVDHATVLHSGEYYMFESDSGEEDE 1372
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: si:dkey-11f4.7 (si:dkey-11f4.7 [Source:ZFIN;Acc:ZDB-GENE-070912-361]) HSP 1 Score: 264.618 bits (675), Expect = 4.507e-79 Identity = 128/286 (44.76%), Postives = 186/286 (65.03%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFS 5423
L ++ +++F+ ++ YS DVY MF+ + ++F II+ GY AFG + + + L + ++P F++ML+ QF +I+DRAL+LRK ++GK VFQ+ V IH W+FF+ P ++ ++N Q YF KC+YF LS+YQIK GYP R+LGNFLTK +NY NLFLF+G+ LVPFL ELR VMDW+WTDT LSL +W+ VED++A IF+LKCWR +E +YP RG + V KY +GG ++ W PL+ S++ S+ V N P + L G+
Sbjct: 3 LHIYLPIRQFFYDIIHPEYSPVCDVYALMFLIDVVNFIIIIFGYWAFGKHSAAADIT-ESLSEDQVPEAFLVMLLIQFSTMIVDRALYLRKTLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNRVAQLWYFVKCIYFGLSAYQIKCGYPNRVLGNFLTKNHNYFNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSNWICVEDIYANIFILKCWREAEKKYPHRRGQRKKKVVKYTMGGFIIFALICIVWFPLLFMSLVKSVAGVTNQPLDVSIQLSILGYE 287
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 513.457 bits (1321), Expect = 1.259e-148 Identity = 304/822 (36.98%), Postives = 467/822 (56.81%), Query Frame = 3
Query: 4008 NNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW----------------------KGFKDKF---------------NIKEPEKKTNFNTLQTSS------LTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQD----ALVLGSENSLNPLESYMIMLSIERSTSDWWQL-HSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
N + + +E +++F + R LI A+ N ++ S+M+CY ++++NHMIS +M++L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F +V+ KD P+F P +GI K E Y DL+QL LF HR LK HGLW G +D ++ PE+KT TSS +S +L+ ++ +++F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ + LQ ++D+E+ ++ + YK N A+ F++S+ +D+TI + S S+W+I+PP++ + ++ L+ + + ++I SL + E+ +KY + + G R +A + Q+ +++L EN+ +WW + SHKEF D + ++FS+++S G L + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 1296 NKMFYDEELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVD-YTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERLIQEP---DFTAVISWSIR-------------------SLGAKAEVTG-----EKYTISLAGQTRRELADMMNNQEFVNISVLLRKENT-------------SEGVREWWVVNQSHKEF-------IKKDGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2067 HSP 2 Score: 149.058 bits (375), Expect = 6.375e-35 Identity = 99/288 (34.38%), Postives = 154/288 (53.47%), Query Frame = 2
Query: 692 MMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNI--NGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVS----SQIDRARSSVIFED-NSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
+ AWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ +I DE+ + G+ E K P L+ I + V FWL LR ++ E+ L S+I ED N K L + + KYWI+ C VS + ++ + ++YMM + + + Y +WRR + +W V+VY++ VL IYT+QFK F LW N T +E L D G E F+++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 245 LQAWSITYHSWLTFVLLIWSCALWMVRNRRKYAMLSSPFMVMYGNLLLTLQYIWSIALQSDELPEVM-------------GLLERKKP-EELVSKIIFTVTFWLLLRQHLTEQKALKQKELALSEIKVGSEDKEVEDENDIMKVLGKLVQAMFVKYWIYVCGGMFFFVSFEGKIVMYKIIYMMLFLFCVALYQVHYEWWRRILKYFWMSVVVYTMLVLVFIYTYQFKSFPGLWMNMTGLDKEKLADLGLETFNLTDLFTRIFIPTSFLLVCILHLHYFHDRFLQLTDL 518 HSP 3 Score: 85.5001 bits (210), Expect = 1.048e-15 Identity = 70/244 (28.69%), Postives = 119/244 (48.77%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSR 3017
WL+ P ++ P L+ D + +C +LQ VF+ EN + G+N I N + + DFI + SY+D K I+F + +W L I+F G R ++FC+GY++ + G +L + +L W+ ++ YN +I +K N+ VS ++ CWLI + C T + + C + + WD +CF FL++QR++F + F +VV D+K + SR
Sbjct: 849 WLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCR-SYLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMK-NVLSVSVLF--------HCWLIQAFSLSC--TVKGYFIPQNTPDCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1080
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 511.531 bits (1316), Expect = 2.397e-148 Identity = 303/816 (37.13%), Postives = 464/816 (56.86%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW----------------------KGFKDKF---------------NIKEPEKKTNFNTLQTSS------LTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQD----ALVLGSENSLNPLESYMIMLSIERSTSDWWQL-HSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
+E +++F + R LI A+ N ++ S+M+CY ++++NHMIS +M++L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F +V+ KD P+F P +GI K E Y DL+QL LF HR LK HGLW G +D ++ PE+KT TSS +S +L+ ++ +++F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ + LQ ++D+E+ ++ + YK N A+ F++S+ +D+TI + S S+W+I+PP++ + ++ L+ + + ++I SL + E+ +KY + + G R +A + Q+ +++L EN+ +WW + SHKEF D + ++FS+++S G L + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 1228 EELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVD-YTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERLIQEP---DFTAVISWSIR-------------------SLGAKAEVTG-----EKYTISLAGQTRRELADMMNNQEFVNISVLLRKENT-------------SEGVREWWVVNQSHKEF-------IKKDGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 1993 HSP 2 Score: 149.828 bits (377), Expect = 3.033e-35 Identity = 102/304 (33.55%), Postives = 164/304 (53.95%), Query Frame = 2
Query: 692 MMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNI--NGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTP-KRISFSR*NLETRNKLHH 1594
+ AWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ +I DE+ + G+ E K P L+ I + V FWL LR ++ E+ L Q + A S I ++N K L + + KYWI+ C VS + ++ + ++YMM + + + Y +WRR + +W V+VY++ VL IYT+QFK F LW N T +E L D G E F+++ L + P L+V I+ +HYFH+ F++++DL R+ + ++ K+ H
Sbjct: 231 LQAWSITYHSWLTFVLLIWSCALWMVRNRRKYAMLSSPFMVMYGNLLLTLQYIWSIALQSDELPEVM-------------GLLERKKP-EELVSKIIFTVTFWLLLRQHLTEQKALK---QKELALSE-IKDENDIMKVLGKLVQAMFVKYWIYVCGGMFFFVSFEGKIVMYKIIYMMLFLFCVALYQVHYEWWRRILKYFWMSVVVYTMLVLVFIYTYQFKSFPGLWMNMTGLDKEKLADLGLETFNLTDLFTRIFIPTSFLLVCILHLHYFHDRFLQLTDLKAVTRMQQIQDSVRDSAKIQH 516 HSP 3 Score: 85.1149 bits (209), Expect = 1.665e-15 Identity = 72/248 (29.03%), Postives = 118/248 (47.58%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHC------IPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSR 3017
WL+ P ++ P L+ D + +C +LQ VF+ EN + G+N I N + + DFI + SY+D K I+F + +W L I+F G R ++FC+GY++ + G +L + +L W+ ++ YN +I +K N+ VS ++ CWLI + C IP + G I WD +CF FL++QR++F + F +VV D+K + SR
Sbjct: 836 WLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCR-SYLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMK-NVLSVSVLF--------HCWLIQAFSLSCTVKGYFIPQNTPDCQLP-SGEAGII-----WDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1067
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 507.294 bits (1305), Expect = 3.755e-147 Identity = 299/787 (37.99%), Postives = 461/787 (58.58%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSR----FIL----------LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-TIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTS---DWWQL-HSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
++ +++F + R LI A+ N ++ S+M+CY ++++NHMIS +M++L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F +V+ KD P+F P +GI K E Y DL+QL LF HR LK HGLW D+ ++ E + + S + R FIL L+ ++ +++F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ + LQ ++D+E+ ++ + YK N A+ F++S+ +D+TI + S S+W+I+PP++ + ++ L+ + + ++I R I+SLF +P ++ P F + L L + + + ++L E ++ +WW + SHKEF D + ++FS+++S G L + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 1196 EKLEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVD-YTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLW----DEDDVTEKATDKDDTDGEISEASGRRDSFFILYILCFFPSRILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERLIQEP---DFTAVISWS-----------------------IRRYIISSLFYNLPNSFSY----RPIFHIY-------PLCLKAPSDVTAKPILHVLLRKENTSEGVREWWVVNQSHKEF-------IKKDGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 1931 HSP 2 Score: 169.088 bits (427), Expect = 4.254e-41 Identity = 111/315 (35.24%), Postives = 179/315 (56.83%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNI--NGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFED-NSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLH 1591
++K SYI + I+MMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ +I DE+ ++ FE +++ +G +I L+ I + V FWL LR ++ E+ L ++ + V ED N K L + + KYWI+ C VS + ++ + ++YMM + + + Y +WRR + +W V+VY++ VL IYT+QFK F LW N T +E L D G E F+++ L + P L+V I+ +HYFH+ F++++DL K ++ E+RNK H
Sbjct: 161 IMKQSYICALISMMAWSITYHSWLTFVLLIWSCALWMVRNRRKYAMLSSPFMVMYGNLLLTLQYIWSIALQSDELPEVME--FESNYKM--YG------NYILLVFQIIFTVTFWLLLRQHLTEQKALK-QKELALSEIKVGMEDENDIMKVLGKLVQAMFVKYWIYVCGGMFFFVSFEGKIVMYKIIYMMLFLFCVALYQVHYEWWRRILKYFWMSVVVYTMLVLVFIYTYQFKSFPGLWMNMTGLDKEKLADLGLETFNLTDLFTRIFIPTSFLLVCILHLHYFHDRFLQLTDL--KAVTRDSKEPESRNKWH 462 HSP 3 Score: 97.8265 bits (242), Expect = 2.118e-19 Identity = 73/244 (29.92%), Postives = 124/244 (50.82%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSR 3017
WL+ P ++ P L+ D + +C +LQ VF+ EN + G+N I N + + DFI + SY+D K I+F + +W L I+F G R ++FC+GY++ + G +L + +L W+ ++ YN +I +K L + +C YI+++I S CWLI + C T + + C + + WD +CF FL++QR++F + F +VV D+K + SR
Sbjct: 764 WLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCR-SYLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMKNVLSIGACGYIEYLIKDS-CWLIQAFSLSC--TVKGYFIPQNTPDCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1003
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 496.893 bits (1278), Expect = 1.497e-142 Identity = 306/864 (35.42%), Postives = 470/864 (54.40%), Query Frame = 3
Query: 3993 HINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW----------------------KGFKD---------------KFNIKEPEKKTNFNTLQTSS----------------------------------LTSRFILLKPFI--TVKKFYMNLASYRY-------SKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQD----ALVLGSENSLNPLESYMIMLSIERSTSDWWQL-HSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
H + + + + +E +++F + R LI A+ N ++ S+M+CY ++++NHMIS +M++L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F +V+ KD P+F P +GI K E Y DL+QL LF HR LK HGLW G +D ++ PE+KT TSS L + I K F T+ + Y+ + + Y S DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ + LQ ++D+E+ ++ + YK N A+ F++S+ +D+TI + S S+W+I+PP++ + ++ L+ + + ++I +N+SL + E+ +KY + + G R +A + Q+ +++L EN+ +WW + SHKEF D + ++FS+++S G L + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 1461 HTDFFHRMFYDEELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVD-YTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSSQKGSSIPSIKLKSRKELILEKLREQLIKAKAFTIKTILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERLIQEP---DFTAVISWS----------------IRRNVSLGAKAEVTG-----EKYTISLAGQTRRELADMMNNQEFVNISVLLRKENT-------------SEGVREWWVVNQSHKEF-------IKKDGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2277 HSP 2 Score: 140.584 bits (353), Expect = 1.990e-32 Identity = 115/412 (27.91%), Postives = 199/412 (48.30%), Query Frame = 2
Query: 410 DFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNR---FTEHIHNTET-----------------TATGMPAISLPFIWSVITSLVKNS-----YIFS------FIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNI--NGDEIMNTIKIFFEPYFEISEFGIFEWKIP--FIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFED--NSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
+ NP L L+Y + ++WL +E I + + AA++ ++ R ++ H E G+ A ++ + + I+ L+ + YIF+ + AWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ +I DE+ + G+ E K P + + I + FWL LR ++ E+ L ++ + V ED ++ + L + + KYWI+ C VS + ++ + ++YMM + + + Y +WRR + +W V+VY++ VL IYT+QFK F LW N T +E L D G E F+++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 180 QYTNPVMLLVLYYTLATLIRLWL-QEPIN----VEEEKEEDCSPAALTAERRRSLWYSSHYTTDERQVWLFRSRNIQLVLSLMAQMGLLAGNVGLLLNYISLLISSCSLCLHYIFTSSNTDCMYLLQAWSITYHSWLTFVLLIWSCALWMVRNRRKYAMLSSPFMVMYGNLLLTLQYIWSIALQSDELPEVM-------------GLLERKKPEELVSKVTIIKF--TFWLLLRQHLTEQKALK-QKELALSEIKVGSEDKGHNEMQVLGKLVQAMFVKYWIYVCGGMFFFVSFEGKIVMYKIIYMMLFLFCVALYQVHYEWWRRILKYFWMSVVVYTMLVLVFIYTYQFKSFPGLWMNMTGLDKEKLADLGLETFNLTDLFTRIFIPTSFLLVCILHLHYFHDRFLQLTDL 570 HSP 3 Score: 117.087 bits (292), Expect = 2.805e-25 Identity = 93/320 (29.06%), Postives = 156/320 (48.75%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHC------IPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQN---------YGRPLPNEH-YLVLRSGDYFLFE 3203
WL+ P ++ P L+ D + +C +LQ VF+ EN + G+N I N + + DFI + SY+D K I+F + +W L I+F G R ++FC+GY++ + G +L + +L W+ ++ YN +I +K L + +C YI+++I S CWLI + C IP + G I WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K + R H + Y P+ + L+++SGDY+LFE
Sbjct: 962 WLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCR-SYLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMKNVLSIGACGYIEYLIKDS-CWLIQAFSLSCTVKGYFIPQNTPDCQLP-SGEAGII-----WDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQYGRFSFLHIHVLYIYLSSIYLSICPHTYSVLMVKSGDYYLFE 1273
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: chordc1 (cysteine and histidine rich domain containing 1 [Source:Xenbase;Acc:XB-GENE-962949]) HSP 1 Score: 440.654 bits (1132), Expect = 1.245e-124 Identity = 287/813 (35.30%), Postives = 458/813 (56.33%), Query Frame = 3
Query: 4029 ETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIES-DVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW---------------KGFKDKF--------------NIKEPEKKTNFNTLQTSSLTSRFILLKPFIT-------VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERN-PSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGL-PRFLVA---TKTDFQDALVLGSENSLNPLESYMIMLSIERSTS-----DWW--QLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFT 6317
E S++Q F +S SR+ L++A+ N V +S++LCY I+++N+M+S +++SL P+ +FLW MLS +PS +W+ I++T+++++IKY+FQF F + + + PFF P LG+ K++ Y DL+QL +LF HR L ++GLW KG K + ++++ ++K + ++Q S + F + VK F+ ++ + DVY +MF+ + + F IIV G+ AFG + + A L D ++P F++M++ QF ++IDRAL+LRK V+GKL+FQ+ VI IHVW+FF+ P ++ +N Q YF KC+YFALS+YQI+ GYP RILGNFLTKKYN+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL +WM VED++A IF++KC R +E +YP P+G + + KY +GGL+++F W PL+ S++ S+ V N P +T + G+ ++ +++ +Q + +Y + ++ A+ F+ + +D+ I S S+W I+PP+++ K L + + L + +R+ T +T ER E+A L + V ++ L P+++ A + + L E S +E + + + S +WW L + DC + IF++++S G L + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +IY+VRE LEE+L AKLIF+YRS ETMI++T
Sbjct: 1351 ELSESQHFFQSQSRILRLLLALYNFVAAHSELLCYFIIILNNMVSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEGKPFFPPRVLGLEKSDSYIKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDKGSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQERGAESNWTCAVQFTSLRNIYQPVKAFFHDILHTKNRAATDVYAFMFLADVVDFVIIVFGFWAFGKHSAAADIASS-LSDDQVPEAFLVMVLIQFSTMVIDRALYLRKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGGYEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPPSREQMRKELQNGSSDITLRFTWDFQRDLAKGGTVEHTSEKHTKDLEPGSQERMELADLLQGVRDTPVSIQHLFPKYIRAPNGPEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVEWWVITLKDCEGEDC--------NILPMVIFNDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIKWT 2153 HSP 2 Score: 148.673 bits (374), Expect = 6.838e-35 Identity = 101/289 (34.95%), Postives = 157/289 (54.33%), Query Frame = 2
Query: 677 FSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKI--RLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLT 1537
FSFI + +TY SWLTFVLL+ AC++W++ + R ++ SPFI+ YG+ L + YV +++ E + T F + +S+ G+ P + + + Y + FWL L ++ EK R S + V + + K + AKYWI+ C ++VS ++ + +VYM+ ++ + F YS WR+ + +WWLV+ Y++ VL IYTFQF+ F E W N T T E L D G E F +S L +L P L+ I+Q+HYFH PFM M++L
Sbjct: 237 FSFILTITCGITYHSWLTFVLLLWACLIWMVRNRRQFAMLCSPFILMYGVTLCSLQYVWSMDLREELPTQLGFMK----LSQLGLVRAPYPCLNMGALLLYTLTFWLLLHQFVTEKFLKRKKFMSPL----LEVTVAEKNLLKRFGEQVKSFYAKYWIYVCGGMFIVVSFAGRLVVYKIVYMLLFLLCLVLFQVYYSLWRKLLTFFWWLVVAYTMLVLITIYTFQFEEFPEYWKNLTNLTDEQLGDIGLERFSVSELFTSILIPGFFLLACILQLHYFHRPFMHMTNLA 517 HSP 3 Score: 100.523 bits (249), Expect = 2.969e-20 Identity = 75/258 (29.07%), Postives = 129/258 (50.00%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIE----------NNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSR 3017
L WL+LP + P++ LI D + + V Q+ VF E N+ +Y+ ++RP N +P +FI N SY+D +K +F + +W L +VF G R ++F LGY++ G + K L W+ ++ YN +IL K L L+SCV++ + + CW+I + + C ++ S+ +E + WD +CF+FL++QR++F + F +VVLD++ ++ TSR
Sbjct: 854 LIKWLYLPDFYTTPKSVNLISDFVLLIGVAQQWKVFINEKKEEWYTMAGENVEEYEAPKDRP---NPVP-----NFI-NCQSYLDMVKVAVFRYLFWFVLTVVFITGATRISVFGLGYLMSCFYLLLSGTTLLQKPMKAKLVLWDCLILYNITVILSKNMLSLLSCVFVQQ-MQTNFCWVIQLFSLVCTVKGYYNPQDMDKDRDCSLPVEEA------GIIWDSICFLFLLLQRRVFLSCYFRHVVLDLRASSLQTSR 1095
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.897 bits (1021), Expect = 4.771e-111 Identity = 224/595 (37.65%), Postives = 349/595 (58.66%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF----TIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERSTSDWW--QLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP+K ++ L D ++ +RN + + L++ R IA + T V ++ + + V +D + L SEN+ + + ++ +S S+WW L + F+ S+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2191 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMT-LGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRIFNQGSQ------ALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2776 HSP 2 Score: 128.642 bits (322), Expect = 8.489e-29 Identity = 98/340 (28.82%), Postives = 159/340 (46.76%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRL----------SVSSQIDRARSSVI-------------------------------------FEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V Y +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + +D K L + L KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 496 IMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALREKEALLSEVKIGSQELEEKDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 821 HSP 3 Score: 123.25 bits (308), Expect = 3.637e-27 Identity = 97/338 (28.70%), Postives = 166/338 (49.11%), Query Frame = 3
Query: 2271 RVYPFHF--PYLLED---WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
R YP+ F Y ++ WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI ++ S CWLI + C T + + ++ C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L SG+ ++ EED D+R D
Sbjct: 1220 RDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGALVRNS-CWLIQAFSLAC--TVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEED--DEREAD 1551 HSP 4 Score: 110.538 bits (275), Expect = 2.077e-23 Identity = 65/149 (43.62%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM S ++++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F D+ + K+ P+F P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1918 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLE-IYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2065
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.897 bits (1021), Expect = 4.944e-111 Identity = 224/595 (37.65%), Postives = 349/595 (58.66%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF----TIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERSTSDWW--QLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP+K ++ L D ++ +RN + + L++ R IA + T V ++ + + V +D + L SEN+ + + ++ +S S+WW L + F+ S+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2166 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMT-LGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRIFNQGSQ------ALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2751 HSP 2 Score: 128.257 bits (321), Expect = 8.686e-29 Identity = 98/340 (28.82%), Postives = 159/340 (46.76%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRL----------SVSSQIDRARSSVI-------------------------------------FEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V Y +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + +D K L + L KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 496 IMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALREKEALLSEVKIGSQELEEKDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 821 HSP 3 Score: 123.25 bits (308), Expect = 3.660e-27 Identity = 97/338 (28.70%), Postives = 166/338 (49.11%), Query Frame = 3
Query: 2271 RVYPFHF--PYLLED---WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
R YP+ F Y ++ WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI ++ S CWLI + C T + + ++ C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L SG+ ++ EED D+R D
Sbjct: 1195 RDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGALVRNS-CWLIQAFSLAC--TVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEED--DEREAD 1526 HSP 4 Score: 110.538 bits (275), Expect = 2.108e-23 Identity = 65/149 (43.62%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM S ++++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F D+ + K+ P+F P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1893 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLE-IYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2040
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.512 bits (1020), Expect = 7.034e-111 Identity = 224/595 (37.65%), Postives = 349/595 (58.66%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF----TIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERSTSDWW--QLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP+K ++ L D ++ +RN + + L++ R IA + T V ++ + + V +D + L SEN+ + + ++ +S S+WW L + F+ S+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2237 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMT-LGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRIFNQGSQ------ALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2822 HSP 2 Score: 123.25 bits (308), Expect = 3.683e-27 Identity = 97/338 (28.70%), Postives = 166/338 (49.11%), Query Frame = 3
Query: 2271 RVYPFHF--PYLLED---WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
R YP+ F Y ++ WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI ++ S CWLI + C T + + ++ C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L SG+ ++ EED D+R D
Sbjct: 1210 RDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGALVRNS-CWLIQAFSLAC--TVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEED--DEREAD 1541 HSP 3 Score: 122.479 bits (306), Expect = 6.365e-27 Identity = 97/335 (28.96%), Postives = 157/335 (46.87%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIF------------------------------------------EDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V Y +L+ + Y+ + EI + E E G KI F +T L+ LT + ++EK L +I +D K L + L KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 496 IMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---ITFWLLLRQHLTEQKALREKEALLSEVKIGSQELEEKEDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 822 HSP 4 Score: 110.538 bits (275), Expect = 2.138e-23 Identity = 65/149 (43.62%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM S ++++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F D+ + K+ P+F P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1964 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLE-IYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2111
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 328.946 bits (842), Expect = 3.778e-100 Identity = 153/360 (42.50%), Postives = 234/360 (65.00%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLD 5645
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP+K ++ L D
Sbjct: 5 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTD 363
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 325.479 bits (833), Expect = 1.290e-98 Identity = 150/350 (42.86%), Postives = 228/350 (65.14%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPN 5615
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP
Sbjct: 60 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPK 408
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|M9MSG8|PIEZO_DROME (Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster OX=7227 GN=Piezo PE=2 SV=1) HSP 1 Score: 416.001 bits (1068), Expect = 6.344e-116 Identity = 271/896 (30.25%), Postives = 471/896 (52.57%), Query Frame = 3
Query: 3891 QTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK-GFKD-----------------KFNIKEPEK---------------------------KTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPG-TGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----------------TIPK-KYAVLVKGL-PRFL-VATKTDFQDALVLGSEN-SLNPLESYMIMLSIERSTSD-WWQL--HSHKEF--DCLSRNPFSPDKTKFFIFSERISDNLFGQLFS---RXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMD 6353
Q H + ++EL V + I++ P +E Q+ + ++++ ++ +D++CY+++ +N +++ +++SL P+ VFLW LS PRP+ +W+ +I YTQ ++LIK +FQFK I S+ + L + P G+ HYA+ DL+ L VLFLHR LK+ GLWK G+KD N+ +P+ KT N L+ + TS ++ KF+ +L ++ DVY MF+C+F++FF+++ G+ AFG T S +L ++K+PIPF++ML+ QF+ I+IDRAL+LRK ++ K++F F VI IH+W+FF+ P ++ +N+ P Y KC Y LSSYQIKSGYP RILGNF TK ++ +N+ FK Y+ +PFLYELR ++DW+ D+ ++++ W+++ED+F+ I++++C R+SE ++P R + ++K ++GG +++ +C WGPL L ++ ++ N PFH L++ + IY N+ + + ++ + Y+ + + Y AL+F+ ++ DV + ++ S S+W+I PP++ + L + S + P+ ++ + S R + + T P+ + V++ G+ P+F+ V D VL ++ PL +I + + T+ WW++ + + F + LS+ +S + +++ +D F FS GIIG+Y ++ +A R +++ + I E+LPYVDR+L+L +IYLVRE F LEE L AKL+F+YRS ET+I++TR K+ +D+ D
Sbjct: 1657 QQHQHIRAAEEIIELPVDTVDGVAHRKQSINSSPPAKGAGEFNLEEENFA----QRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLI--WSNYHQL-PNQPLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTS---------SLYKFFFSLV-HKSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYTTNNYDSIFE-INPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPL---VIKMHRDNETNGLWWEIRDYCNDTFYNETLSKFAYSNCTSGIVMYT--FNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTRPKEEYVDDDGD 2529 HSP 2 Score: 156.377 bits (394), Expect = 2.189e-36 Identity = 111/364 (30.49%), Postives = 163/364 (44.78%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYK---YKGGENRPIV-----FNELP-KTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT---------RENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQ-------------NYGRPLPNE----------HYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLK 3263
++ W LP L+ KLI D I + +N Q +F IE Y GG NR ++ +P DF S +Y D LK + C FYW TL +VF G L LGY+I A ++ W G F L ++ W +L +N ILIK + Q+ C+++ + CWL+H+LGI C E +++ C I + WD +CF F+I Q +IF + F +++ D K N SRGA +I + + E Q+ K+K K+ RI T Q +G PLP H R+GDY++FEE ++ E D I D +FL+
Sbjct: 1063 IQRWAMLPGALHFNHVPKLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTHDFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQLTK-DCCWLVHMLGITCTSNVLTEQIMLPEEAELALK-PGECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMFEEMDDKFEL-DLIHDEIDFLE 1423 HSP 3 Score: 147.517 bits (371), Expect = 9.784e-34 Identity = 127/435 (29.20%), Postives = 206/435 (47.36%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFF--DFMNPFALFALFYIHSLDSK----IWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFT----EHIHNTETTATG-MPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEIS-EFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQ-----------IDRARSSVIFEDNST----FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQ-VKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTP 1540
+L+GL I++ C V + + ++NPFALF ++ +L +K L R++ + S + +V+Q+ N E E T T + IS F+ SV + +NSYIF+ I MMAWS+ Y SWLTFVLL+ A +LW++P+ R A + SPFIV Y L+ Y+ ++N +E+ ++ +I E I P +PL++ ++++FW+T R + KEK S + A SS + D K + L + WI+ + + L +I + + + YM + + F S W + MY +W +I Y++ +L IYT+QF F W +Y + KD G + + L L+SP I++I+T+IQVHYFH F+ P
Sbjct: 294 ARLIGLEPLIESYCSPDIRVFLYNNKLSLDSYLNPFALFFAYFALALTTKHLIKPRLVRQSTRKARTPQPLESGSSVAPSVTQRGNDMQLESMEQRSEQENTTTSILDQISYGFV-SVGGFIYQNSYIFTNILMMAWSIVYHSWLTFVLLLSANVLWMIPNQRKAMMRSSPFIVLYAEALLIAQYIYGMDLNNEELPTSVPTAGINLQQIGFERPIENQMRPCVPLIVKTAFVLMFWVTSRQFFKEKRDRRRDSTLADFIAPLQITVGSAGSSYLINDGKKTSKFLKKAGDVIKNLLVRLWIWLLVLVIFLCAITGENMTGFRICYMALFLFFLLVFQSSSKAWVKIMYGFWLFLIFYAMSILILIYTYQFDKFDTYWSDYLNVSATLQKDIGLKRYQTKDLFLHLVSPTIIVILTVIQVHYFHKRFIASLQQQP 727
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q9H5I5|PIEZ2_HUMAN (Piezo-type mechanosensitive ion channel component 2 OS=Homo sapiens OX=9606 GN=PIEZO2 PE=1 SV=2) HSP 1 Score: 399.438 bits (1025), Expect = 1.048e-110 Identity = 229/597 (38.36%), Postives = 353/597 (59.13%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERT---EIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERST---SDWWQLHSHKEFDCLSRNPFSPDKT--KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M +N + + A+ F++++E +D+T+ + S S+W+I+PP+K + LLD + ++ +RN S ++ D ++T + IA T K V ++ + + V +D + L SEN+ + I+LS + +T S+WW L + ++P+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2165 LEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDI---TIILSRDNTTKYNSEWWVL------NLTGNRIYNPNSQALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2750 HSP 2 Score: 130.568 bits (327), Expect = 1.479e-28 Identity = 99/342 (28.95%), Postives = 163/342 (47.66%), Query Frame = 2
Query: 641 SVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLS----------VSSQIDRARSSVIFE----------------------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
SV ++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V YG +L+ + Y+ + EI + E E G KI F + FWL LR ++ E+ L + SQ + + + + + K L + + KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 491 SVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---------ITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 818 HSP 3 Score: 128.642 bits (322), Expect = 5.003e-28 Identity = 66/149 (44.30%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM+S +M++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F +V + KD P+ P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1892 DELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVE-VNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2039 HSP 4 Score: 122.094 bits (305), Expect = 4.496e-26 Identity = 91/320 (28.44%), Postives = 158/320 (49.38%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI +++ S CWLI + C T + + + + C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L G+ ++ EED D+R D
Sbjct: 1211 WLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNS-CWLIQAFSLAC--TVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEED--DEREAD 1524
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q8CD54|PIEZ2_MOUSE (Piezo-type mechanosensitive ion channel component 2 OS=Mus musculus OX=10090 GN=Piezo2 PE=1 SV=2) HSP 1 Score: 397.512 bits (1020), Expect = 4.872e-110 Identity = 224/595 (37.65%), Postives = 349/595 (58.66%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF----TIPKKYAVLVKGLPRFLVATKTDFQDALV--LGSENSLNPLESYMIMLSIERSTSDWW--QLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +++F+ +L YS DVYV MF+ + + F IIV G+ AFG + + L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ K++ + Q YF KCVYF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IF+LKCWR SE YP PRG + KY +GG++++ W PL+ S+I S+ V N P +T+ G+ I+ +++ L+ M + +YN + N A+ F++++E +DVT+ + S S+W+I+PP+K ++ L D ++ +RN + + L++ R IA + T V ++ + + V +D + L SEN+ + + ++ +S S+WW L + F+ S+ + +F++++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2235 LQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMT-LGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRIFNQGSQ------ALELVVFNDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2820 HSP 2 Score: 123.25 bits (308), Expect = 2.470e-26 Identity = 97/338 (28.70%), Postives = 166/338 (49.11%), Query Frame = 3
Query: 2271 RVYPFHF--PYLLED---WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPIVFNELPKTEDK-----DFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDD 3245
R YP+ F Y ++ WL+ P ++ P L+ D + +C +LQ +F+ EN + G+N I N + + DFI + SY+D K IIF + +W L I+F G R ++FC+GY++ + G +L K +L W+ ++ YN +I +K L + +C YI ++ S CWLI + C T + + ++ C + + WD +CF FL++QR++F + F +VV D+K + SRGA L ++ + E+E + ++K ++ RI+ Q Y + L SG+ ++ EED D+R D
Sbjct: 1210 RDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCR-SYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGALVRNS-CWLIQAFSLAC--TVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEED--DEREAD 1541 HSP 3 Score: 122.094 bits (305), Expect = 4.527e-26 Identity = 97/335 (28.96%), Postives = 157/335 (46.87%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIF------------------------------------------EDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFVLLI +C LW++ + R ++ SPF+V Y +L+ + Y+ + EI + E E G KI F +T L+ LT + ++EK L +I +D K L + L KYWI+ C VS + ++ + ++YM+ + + + Y +WR+ + +W V++Y++ VL IYT+QF+ F LW N T +E L+D G + F ++ L + P L+V I+ +HYFH+ F++++DL
Sbjct: 496 IMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELPEIKKV-----PGFLEKKEPGELASKILFT---ITFWLLLRQHLTEQKALREKEALLSEVKIGSQELEEKEDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDL 822 HSP 4 Score: 110.538 bits (275), Expect = 1.470e-22 Identity = 65/149 (43.62%), Postives = 98/149 (65.77%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
DE ++++F R LL A+ N ++ S+M+CY ++++NHM S ++++LL P+ +FLWAMLS PRPS +W+ I+YT++ I++KY FQF F D+ + K+ P+F P +G+ K E Y L DL+QL LF HR LK HGLW
Sbjct: 1962 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLE-IYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLW 2109
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q92508|PIEZ1_HUMAN (Piezo-type mechanosensitive ion channel component 1 OS=Homo sapiens OX=9606 GN=PIEZO1 PE=1 SV=4) HSP 1 Score: 345.51 bits (885), Expect = 3.742e-94 Identity = 218/593 (36.76%), Postives = 338/593 (57.00%), Query Frame = 3
Query: 4587 VKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSL----TERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTS-----DWWQLHSHK-EFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
+++F+ ++ +Y DVY MF+ + + F II+ G+ AFG + +T L D ++P F++ML+ QF +++DRAL+LRK V+GKL FQ+ V+ IH+W+FF+ P ++ +N + Q YF KC+YFALS+YQI+ GYP RILGNFLTKKYN+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL WM VED++A IF++KC R +E +YP P+G + + KY +GGL+++F W PL+ S++ S+ V N P +TL+ G+ ++ +++ + + Y + + +A+ F+ + P+D+ I S ++W I+PP++ + L + + L +R D TV L+L T R ++ASL +V++ L P+++ A + + N I L E+ +WW + + DC + IFS+++S G + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE + LEE+L AKLIF+YRS ETMI++TR K+
Sbjct: 1942 LRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDIT-SSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQR---DLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDC--------NLLPMVIFSDKVSPPSLG-FLAGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2521 HSP 2 Score: 172.94 bits (437), Expect = 1.686e-41 Identity = 103/297 (34.68%), Postives = 165/297 (55.56%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLC----AKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++ SY+ + IAMM WS+TY SWLTFVLL+ AC++W + ++ SP I+ YG+ L + YV + ++ + P + + G+ + P + L + Y + FWL LR ++KEK+ S +V + + ++L+ L +L AKYWI+ C ++VS ++ + +VYM ++ +T F YS WR+ + +WWLV+ Y++ VL +YTFQF+ F W N T FT E L D G E F +S L +L P L+ I+Q+HYFH PFM+++D+
Sbjct: 419 IMDQSYVCALIAMMVWSITYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGMTLCCLRYVWAM---DLRPELPTTLGP-VSLRQLGLEHTRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESPAALTEVTVADTEPTRTQTLLQSLGELVKGVYAKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYSLWRKLLKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTGFTDEQLGDLGLEQFSVSELFSSILVPGFFLLACILQLHYFHRPFMQLTDM 711 HSP 3 Score: 107.842 bits (268), Expect = 1.078e-21 Identity = 59/145 (40.69%), Postives = 90/145 (62.07%), Query Frame = 3
Query: 4059 SSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALE-KDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDK 4490
R L+ A+ V +S++LCY I+++NHM++ + SL+ P+ VFLWAMLS PRPS +W+ I++T++ +++KY+FQF F S V ++ P+F P LG+ KT+ Y DL+QL LF HR L +GLW +D
Sbjct: 1668 GQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLWDHEEDS 1812 HSP 4 Score: 91.2781 bits (225), Expect = 1.208e-16 Identity = 96/374 (25.67%), Postives = 161/374 (43.05%), Query Frame = 3
Query: 2241 PKLCI--L*NGSRVYPFHFPYLLEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGEN----RPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHC----------IPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRI--EQTHQNYGR------------------PLPN-----------------EHYLVLRSGDYFLF 3200
P LCI SR P + L WL+LP + P + LI D + +C + Q+ VF E ++ G N P+ P +FI + SY+D LK +F + +WL L +VF G R ++F LGY++ G + + L W+ ++ YN +I+ K L L++CV+++ + CW+I + + C + R+ + +E + WD +CF FL++QR++F + + +V D++ T SRG L N + + + E + ++K ++ RI +Q GR P P+ +H V+ SGDYFLF
Sbjct: 1061 PALCIDYPWRWSRAVPMN--SALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPV---PNFIHCR-SYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALLQRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQ-MQTGFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPVEEA------GIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKHRQGRVDRSRPQDTLGPKDPGLEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLF 1421
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q0KL00|PIEZ1_RAT (Piezo-type mechanosensitive ion channel component 1 OS=Rattus norvegicus OX=10116 GN=Piezo1 PE=1 SV=3) HSP 1 Score: 338.961 bits (868), Expect = 4.747e-92 Identity = 225/638 (35.27%), Postives = 351/638 (55.02%), Query Frame = 3
Query: 4482 KDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSL----TERTEIASLF-TIPKKYAVLVKGLPRFLVATKTDFQDAL----------VLGSENSLNPLESYMIMLSIERSTS------DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
++ I+E K LQ+ L+ +P +++F+ ++ +Y DVY MF+ + + +I+ G+ AFG + +T A L D ++P F+ ML+ QF ++IDRAL+LRK V+G L FQ+ V+ IH+W+FF+ P ++ + Q YF KC+YFALS+YQI+ GYP RILGNFLTKKYN+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL +WM VED++A IF++KC R +E +YP P+G + + KY +GGL+++F W PL+ S+I S+ V N P +TL+ G+ ++ +++ + + ++Y + + +A+ F+ + P+D+ I S ++W I+PP++ L + + L +R D +V L L T R ++A L P + V+ P+++ A + + LG L E S E++ + +WW + DC + P IFS+++S G + YGI+G+Y + + V + +R +S+IS+ I EELP VDRILKL +I+LVRE + LEE+L AKLIF+YRS ETMI++TR K+
Sbjct: 1915 REGLKIREKMKAAG-RRLQSFCLSLAQSFYQP---LRRFFHDILHTKYRAATDVYALMFLADIVDIVVIIFGFWAFGKHSAATDIA-SSLSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGNLAFQVVLVVAIHLWMFFILPAVTERMFRQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPEDYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKHELYNGTADITLRFTWNFQR---DLAKGGSVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLR-REQVGTGTSGEQAGTKASDFLEWWVIELQ---DCQAECNLLP----MVIFSDKVSPPSLG-FLAGYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2535 HSP 2 Score: 157.147 bits (396), Expect = 9.991e-37 Identity = 104/297 (35.02%), Postives = 166/297 (55.89%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKI---RLSVSSQIDRARSSVIFEDNSTF-KSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++ SY+ + IAMM WS+ Y SWLTFVLL+ AC++W + ++ SP I+ YG+ L + YV + E+ T+ + + G+ + P + L + YL+ FWL LR ++KEK+ R + S+ ++ S T +SL + + KYWI+ C ++VS ++ + +VYM ++ +T F Y+ WR+ + ++WWLV+ Y++ VL +YTFQF+ F W N T FT E L D G E F +S L +L P L+ I+Q+HYFH PFM+++DL
Sbjct: 417 ILDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGLTLCCLRYVWAMELPELPTTLGPV-----SLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFVKEKLLKKRKAPSTLLEVTVSDTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDL 708 HSP 3 Score: 114.005 bits (284), Expect = 1.307e-23 Identity = 66/183 (36.07%), Postives = 107/183 (58.47%), Query Frame = 3
Query: 4023 VDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALE-KDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKD---KFNIKEPEKKTNFNTLQTSSLTSR 4559
+ E +A+QF+ R L+ A+ V +S++LCY I+++NHM++ + SL+ P+ VFLWAML+ PRPS +W+ I++T+++++ KY+FQF F S + ++ P+F P LG+ KT+ Y DL+QL LF HR L +GLW +D K + + EK + L S+
Sbjct: 1643 IPELEEAEQFEAQQGRTLRLLRAMYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDGVPKDHCRSSEKDQEAEEESEAKLESQ 1825 HSP 4 Score: 98.5969 bits (244), Expect = 6.010e-19 Identity = 90/344 (26.16%), Postives = 154/344 (44.77%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGEN----RPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHC----------IPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGR---------------PLPN-----------------EHYLVLRSGDYFLF 3200
WL+LP + P + LI D + +C + Q+ VF E ++ G N P+ P +FI + SY+D LK +F + +WL L +VF G R ++F LGY++ G + + L W+ ++ YN +I+ K L L+SCV+++ + + CW+I + + C + TR+ + +E + WD +CF FL++QR++F + F +V D+K T SRG L N + + ++ E + ++K ++ RI + Y + P P+ +H V+ SGDYFLF
Sbjct: 1070 WLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAEQTEEWQRMAGVNTDHLEPLRGEPNPI---PNFIHCR-SYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQM-QSNFCWVIQLFSLVCTVKGYYDPKEMKTRDRDCLLPVEEA------GIIWDSICFFFLLLQRRVFLSHYFLHVSADLKATALQASRGFALYNAANIKNINFHRQTEERSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSTDPQEPGPDSPGGSSPPRTQWWRPWQDHATVIHSGDYFLF 1402
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A504YS87 (Piezo-type mechanosensitive ion channel component OS=Fasciola gigantica OX=46835 GN=FGIG_01349 PE=3 SV=1) HSP 1 Score: 709.138 bits (1829), Expect = 0.000e+0 Identity = 429/1013 (42.35%), Postives = 605/1013 (59.72%), Query Frame = 3
Query: 3582 DTIE--KDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQ-----AQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDS----PFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKD---------------------KFNIKEPEKKTNFNTL---------------QTSSLTSRFILL----KPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTER----------------TEIASLFTIPK----KYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYM-IMLSIER---STSDWWQLHSHKE-------FDCL------SRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
DTI+ + S ++ W K + Y F ++ +D LI +N LT+ R +R ++ EKRL+K R+I + S + + + + T + Q L R N++ N+ H+ + + + + T Q + F++S S FLL++A+GNL I+YS+ CY +L++NHM S +LSL YPL+VFLW MLS PRP+ +WIF+I YT++VI+IKY+FQF+FI + LEK S +LP G++K +HYAL DL+QL LFLHRGYLKN+GLW+ + + +++ P+++++ + + Q S++ R PF + +FY+ + RY+K+VDVY+YMF+CEFI+F+I++ GY +FGP TG A +F+K ++IP+PFI ML+ QFIFIIIDR LFL+K V+GK +FQI +V+LIH W+ F+ P I+RS +NA +APQ LY KCVYF+LS+YQI+SGYP RILGNFLTK YNYLNL LFKGYL++PFLYELRNVMDW+WT +ALSLYHWME+ED++AKIFVLKCWRRSE+ YPTPRG NR K LVGGLL+ FFFLCFWGP+ L S IG+ F NPP C ++ F GF I+E+ SR + +S+ + K C++ + F+ +FE DV + I S +IW+ITPP+ + L D K + L+ + C R+ + +T +T V+ F + L E+ E AS P VL +PR+++ K + A L E+Y+ + +I T WW+L + F+ L S+ + ++ER+SD+LFG++FS YGIIG+YAAYIF+A+RLLR +YSNISY+IR EELP+VDRIL L NEIYLVREN + RLEEQLVAKL F+YRS ETMI++TR + I+D+ DK
Sbjct: 2194 DTIDVTQGSIQQREEGCWSKFKASCMIGYMFIISSVDSLIRLLNGLTRQYRRIRRTIDQEKRLVKRRLIANIDATQEHSRHH-------------LEAAMFEVVANTAEQLQPLMR----NNVESA---PCTNRDLPHEHMRSEHYTVPMGSTYQHHYQREKAFRQSRSHAFLLLIAMGNLAIVYSEWFCYFLLILNHMRSSTILSLPYPLTVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFIYFN---DPLEKPSVSAEALWLPRLFGLDKNDHYALFDLIQLISLFLHRGYLKNNGLWRDHTEFAQDLELVVEENRAAQMRRASRHSVERPKRESSSHAVLEGENSNNQVLSTSQQLSTINPRMSATGKSWNPFAKLHRFYLKMTDPRYNKKVDVYIYMFLCEFIAFWIMIFGYVSFGPSTGMGDNAFEFIKSNRIPLPFISMLLVQFIFIIIDRGLFLQKQVLGKFIFQIIHVLLIHGWLSFILPHITRSPFNASVAPQLLYLIKCVYFSLSAYQIRSGYPHRILGNFLTKNYNYLNLILFKGYLIIPFLYELRNVMDWMWTRSALSLYHWMELEDIYAKIFVLKCWRRSEIAYPTPRGVNRPAGKKALVGGLLLSFFFLCFWGPMALSSFIGATFDFNPPVLCTFSISFGGFPPIFEFTSREGNILRISESVHLDFKRCHEKDKQTFGFLNNFEAKDVRYITIDGFSGNIWAITPPSHSTLREKLADSKSDLLLHFHMRCRRHTKEIQTGQTSVEDIFSRRLGSNEKHQLLRVLNQSTSVEGLEESASSQEEPSFRTTDPVVLDATMPRYVLLRKDRLRAAYA-----KLGQKETYVNVSFNIHHDRLQTQSWWELKEREGPEPVDPCFEVLRGSVLGSKQRAAAKVLSIVTYNERVSDSLFGKVFSNYGIIGMYAAYIFLANRLLRTIYSNISYVIRLEELPHVDRILNLCNEIYLVRENNLLRLEEQLVAKLFFLYRSSETMIKWTRHPKHIIDKFTDK 3178 HSP 2 Score: 280.026 bits (715), Expect = 1.711e-71 Identity = 140/314 (44.59%), Postives = 204/314 (64.97%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN--NIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIP--TRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLP--NEHYLVLRSGDYFLFEEHQEEDE 3224
L WLFLP P A KL D Q++ V LQY+VFKIE + Y GG NRP++ N P +KDFIS+K SY+DY++ +F W YW++L IV G+ TLFCLGYMIL+ +Y W+GQ +L +R L+ SWN+I+ YNF +IL KC+LQ+V CVY + N +CW + + G+ C+ + + + C +++ +WDV CF+F++ QRKIF T+SF +VVLD+ + ++F SRGA LIN+KLM +++E+ +E + K++EK+ I++ GR NEHY++LRSGDY+LFE EED+
Sbjct: 1130 LLQWLFLPGIYGSPNARKLTADFFQFVAVALQYHVFKIEQRPDAESYGGGPNRPVLANTPPGENEKDFISSKESYLDYMRHAVFYWSYWVSLAIVLATGVTWITLFCLGYMILSFIYLWMGQNVMLRKRINLIKSWNVIIGYNFCVILAKCSLQVVGCVYWTRLAN--QCWFVQLFGVQCMDPLSWSKFPPPAYDEECVTVSSGLHWDVFCFLFILFQRKIFMTRSFSHVVLDLNVQSQFASRGAYLINRKLMLVISEQAAREQRSLEKIREKLDVIQRRQAALGRNTANINEHYIMLRSGDYYLFEGDPEEDD 1441 HSP 3 Score: 160.999 bits (406), Expect = 3.538e-52 Identity = 95/258 (36.82%), Postives = 133/258 (51.55%), Query Frame = 2
Query: 1082 DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHHEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELNYLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIVVAI 1855
DN+ ++ L LC KYWI C + +LL+S+Q+ V I +VYMM L+ + F SYSFWRRQM +WW+ +VYS+ VL IYT+QF+ LW +T ++E LKD G E F ++L + LL+PV+ L+V I+QVHYFH PF+K S L R S + E L H STS + +N+ + D N + KL + WR LEIH+ K+I +AI
Sbjct: 662 DNTAYQKFTEVLRSLCVKYWIVVCCLSMLLISLQQPVVIFRIVYMMMLIYFLFVFQVSYSFWRRQMLFFWWINVVYSMAVLLCIYTYQFQNSPTLWRKFTGLSEEVLKDIGLETFHSAALFQRLLTPVVFLVVIILQVHYFHEPFLKRSALDRFR-SVPQQENEASGSLLHRGHTSLPSVSTSTSLSNF---------------------------MEDVNSMFQTVVSKLTSWAVSLTNCCWRFLEIHWIKVIALAI 891 HSP 4 Score: 77.411 bits (189), Expect = 3.538e-52 Identity = 43/133 (32.33%), Postives = 67/133 (50.38%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQL-IILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE 2274
+ +F +Q++ M FQL + N + S QMDN +IGL K +DF ++ + MI+C WH I Y Q ++Y+ + +P +VFP T S+ + L + VK +N+ FYK GLE
Sbjct: 925 TIMFFWTGLQVLCKMCFQLSFVPGNLSLPCDVS--------HNTSQMDNPTWIGLTKINDFYHYSLPMGMVMIVCVCWHAIAYRQRQFYSGPCNVRPREGIVFPRVTIDSMGYDLLNVVKFAVNYGFYKFGLE 1049 HSP 5 Score: 100.908 bits (250), Expect = 4.406e-17 Identity = 62/133 (46.62%), Postives = 88/133 (66.17%), Query Frame = 2
Query: 629 PFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYV--TNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKE 1021
P + S+ S ++NSYI + I+MMAWSVTY+SWL+F+LL+ ACILW++P+SR ACL SP IV Y I+LI I YV N+ +E+ ++ +SE G+ W+ L L I YL+ FWLTLRL++ +
Sbjct: 436 PLLLSLHYSAIRNSYILTLISMMAWSVTYRSWLSFILLLSACILWIMPNSRLACLYASPLIVLYAIVLILIQYVFGMNLTSEELPQSVT---PDGLRLSELGMQRWENAIGALSLQITYLICFWLTLRLFVMD 565
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A4S2LI04 (Piezo-type mechanosensitive ion channel component OS=Opisthorchis felineus OX=147828 GN=CRM22_007115 PE=3 SV=1) HSP 1 Score: 704.131 bits (1816), Expect = 0.000e+0 Identity = 401/934 (42.93%), Postives = 567/934 (60.71%), Query Frame = 3
Query: 3837 KNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEP-HINNT-------------------NNVIFVDETSQAQQ----FQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDI-ESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKG---FKDKFNI-----KEPEKKTN--------FNTLQTSSLTSRFI----------------------LLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSR-GDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-------------------TIPKKYAVLVKGLPRFLVATKTDFQDA-LVLGSENS-LNPLESYMIMLSIERSTSDWWQLHSH---KEFDCLSRNPFS------PDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
+ GQ I++++N L I+ V E + + + N + P H++ ++ +D + QQ F++S SR FLL++A+GN+ I+YS+ CY++LV+NHM S N+LSL+YPL VFLW MLS PRP+ +WIF+I YT++VI+IKY+FQF+FI + + + ++P LG+ K+ HYA+ DL+QL LFLHRG+LKN GLW+ F + K E+ N L T S S+ + PF +++FY + +++K+VDVY+YMF+CEFISF+II+ GY +FGP TG A +F++ +++P PF+ ML+ QFIFIIIDR LFLRK V+GK +FQI +V+LIH W+FF+ P I++S + A APQ LY KCVYF+LS+YQI+SGYPLRILGNFLTKKYNY+NL LFKGYL+VPFLYELRN+MDW+WT++ LSLYHWME+EDV+AKIFV KCWRRSE+ YPTPRG NR K LVGGL++ FFF C W PL L S IG+ FV NPP C +L GF ++E+ SR G++L+ D ++ + C++ ++ + F+ +FE DD+ + I S +IW+ITPP+ D +K L D + L+S ++C R + +T++ V+ F + L E+ E+ + + L +PR+LV + + A LG EN+ +N S++I ++ S WW+L C + F D F+ER+SD+LFG+ F YGI+G+Y AY+F+ +RL R VY+NISY+IR EELP+VDRIL L NEIYLVRENK+ RLEEQLVAKL F+YRS ETMI++TR + I+D+ D+
Sbjct: 2372 RTSGQPTSISVRINRSLIHKHRPDSIIRSVAEDQFYPLDIEVAVFNVVSKSPEHVSGGVPFLDPQISDRCRAALVPGQSIEHLDALDRHQQREKAFRQSRSRPFLLLIALGNMAIVYSEWFCYLLLVVNHMRSSNILSLVYPLVVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFITFNDPSLKPADSAEALWIPRLLGVEKSGHYAIFDLVQLISLFLHRGFLKNDGLWRDHTEFVQDLQLVAERNKVAERVQNGEQVGPDFLRLLSTESAASQMVEGHNVDAVTSGRLTVSRRDALHTWNPFAKLRRFYHKMTDPQFNKKVDVYIYMFLCEFISFWIIMFGYVSFGPSTGMGDNAFEFIRSNRVPFPFVCMLLVQFIFIIIDRGLFLRKQVLGKFIFQILHVLLIHGWLFFILPHITKSPFTAGFAPQLLYLIKCVYFSLSAYQIRSGYPLRILGNFLTKKYNYINLILFKGYLIVPFLYELRNIMDWMWTNSTLSLYHWMELEDVYAKIFVHKCWRRSEIAYPTPRGVNRPAGKKALVGGLILAFFFACLWIPLALSSFIGATFVFNPPVLCTFSLSIGGFPPVFEFTSREGNILKIRQQDLDSFTR-CHEKDLQTVGFLNNFEVDDLRYITIDGFSGNIWAITPPSYDTLVKKLSDASSDLLLHSHMQCRRKTKEIQTSQISVEDIFSRKLQPLEKIELYDVLNTTAVGSAANNTQVKLSSRVLSSSPVTLNAVMPRYLVLKRDRLRPAYATLGRENTYIN--VSFVIHRDPAKNQS-WWELKERAITSSDACFEKLRFPTLGDSWADALSIMTFNERVSDSLFGKWFFTYGILGMYGAYLFLVNRLFRTVYTNISYVIRLEELPHVDRILNLCNEIYLVRENKLLRLEEQLVAKLFFLYRSSETMIKWTRHPKRIIDQFTDR 3301 HSP 2 Score: 235.343 bits (599), Expect = 9.880e-73 Identity = 164/446 (36.77%), Postives = 238/446 (53.36%), Query Frame = 2
Query: 629 PFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRL-----------SVSSQIDRARS------SVIFE------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHHEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELN--------YLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIVVAI 1855
P + S+ S +++SYI + IAMMAW+VTY+SWL+F+LL+ ACI+W+ P+SRAACL SP IV Y I+LI I YV +N K E++E G+ +W L L I +LV FWLTLRL++ E+ SV I R S + E DN+ ++ L LC KYWI C + +LL+SIQ+ V I + YM+ L+ M FF SY FWRRQM +WW+ +VYS+ +L IYT+QFK E W T ++E LKD G E FD ++L LL+PV+ L+V I+QVHYFH PF+K S L+ N+L +E++ + +ST+ Q+ + ++ + L K +AK Y + D N A + + KLI + WR +E+H+ K++ + I
Sbjct: 559 PLLLSLHFSAIRHSYIVTLIAMMAWAVTYRSWLSFILLLSACIVWISPNSRAACLYASPLIVLYAIVLILIQYVYGLNL-TTAELPKQVTPDGLEMAELGMKKWDNSVGALGLQITFLVFFWLTLRLFVNERSYRRFTTRSPTGYPSVGHPIGRGTSIWDRHLATSVESWFGSTFAFGTVDNTAYRRFTELLRALCVKYWIVVCCLSMLLISIQQPVVIFRIFYMVMLIYFMFFFQVSYGFWRRQMIFFWWINVVYSMAILLCIYTYQFKNSPEFWQRTTGLSEEVLKDIGLETFDSAALFARLLTPVLFLVVIILQVHYFHEPFLKRS------------ALDRFNRL-YELRDL---ASTTPQQSADHAATLSPSTTSSLSKLLRGFAKHNRRPMPRQTLYFIEDVNSAFHTIVTKLIAWAISLTNCCWRFMEVHWIKVVALLI 987 HSP 3 Score: 71.633 bits (174), Expect = 9.880e-73 Identity = 39/132 (29.55%), Postives = 65/132 (49.24%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE 2274
+ +F+ + + M FQL ++ C+ NK ++N + GL+K +F + + M +C WH I Y Q ++YN + +P +VFP T S+D+ L + VK +N+ FYK GLE
Sbjct: 1021 TIVFVWTGLFTLCKMCFQLNFVQ-LNVTIVCADSNK------TTHLENASWAGLVKVQNFNHYILPMGALMFVCVFWHAISYRQKQFYNSPHNLRPHEGVVFPDVTIASLDNDLRNVVKFAINYGFYKFGLE 1145 HSP 4 Score: 278.485 bits (711), Expect = 5.704e-71 Identity = 140/318 (44.03%), Postives = 207/318 (65.09%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN--NIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI-PTRENHISISI-ENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPN--EHYLVLRSGDYFLFEEHQEEDEYDDR 3236
L WLF+P P A KL D Q++ V LQY VFKIE ++ +Y GG N+P++ N +P E++DF+S K SY+DYL+ +IF W YW++L IV G+ TLFCLGYMIL+ +Y W+GQ +L RR L+ SWN+I+ YNF +IL KC+LQ+V CVY + + +CW I + G+ C+ P + + + C +++ +WDV+CFIF++ QRK+F T+SF +VV D+ + ++F SRGA LIN+KLM ++E+ +E K++EK+ I++ GR N EHY+++RSGDY+LFE EED+ R
Sbjct: 1226 LLQWLFVPGQYGSPTAKKLTADFFQFVAVALQYQVFKIEKRFSVKEYGGGSNKPVLINNVPGKEERDFVSAKESYLDYLRHLIFYWSYWVSLAIVLATGVTWITLFCLGYMILSFIYLWMGQNVMLRRRSSLIKSWNVIIGYNFCVILAKCSLQVVGCVYWARMSH--QCWFIQLFGVQCMDPMSWSRFEPPVYDKQCETVSSGLHWDVICFIFILFQRKVFMTQSFSHVVFDLNVQSQFASRGAYLINRKLMTDISEQLAREELSLAKIREKLAVIQRRQAVLGRNTDNITEHYIMIRSGDYYLFEGDPEEDDEMPR 1541
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A4S2LHI2 (Piezo-type mechanosensitive ion channel component OS=Opisthorchis felineus OX=147828 GN=CRM22_007115 PE=3 SV=1) HSP 1 Score: 704.131 bits (1816), Expect = 0.000e+0 Identity = 401/934 (42.93%), Postives = 567/934 (60.71%), Query Frame = 3
Query: 3837 KNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEP-HINNT-------------------NNVIFVDETSQAQQ----FQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDI-ESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKG---FKDKFNI-----KEPEKKTN--------FNTLQTSSLTSRFI----------------------LLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSR-GDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-------------------TIPKKYAVLVKGLPRFLVATKTDFQDA-LVLGSENS-LNPLESYMIMLSIERSTSDWWQLHSH---KEFDCLSRNPFS------PDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
+ GQ I++++N L I+ V E + + + N + P H++ ++ +D + QQ F++S SR FLL++A+GN+ I+YS+ CY++LV+NHM S N+LSL+YPL VFLW MLS PRP+ +WIF+I YT++VI+IKY+FQF+FI + + + ++P LG+ K+ HYA+ DL+QL LFLHRG+LKN GLW+ F + K E+ N L T S S+ + PF +++FY + +++K+VDVY+YMF+CEFISF+II+ GY +FGP TG A +F++ +++P PF+ ML+ QFIFIIIDR LFLRK V+GK +FQI +V+LIH W+FF+ P I++S + A APQ LY KCVYF+LS+YQI+SGYPLRILGNFLTKKYNY+NL LFKGYL+VPFLYELRN+MDW+WT++ LSLYHWME+EDV+AKIFV KCWRRSE+ YPTPRG NR K LVGGL++ FFF C W PL L S IG+ FV NPP C +L GF ++E+ SR G++L+ D ++ + C++ ++ + F+ +FE DD+ + I S +IW+ITPP+ D +K L D + L+S ++C R + +T++ V+ F + L E+ E+ + + L +PR+LV + + A LG EN+ +N S++I ++ S WW+L C + F D F+ER+SD+LFG+ F YGI+G+Y AY+F+ +RL R VY+NISY+IR EELP+VDRIL L NEIYLVRENK+ RLEEQLVAKL F+YRS ETMI++TR + I+D+ D+
Sbjct: 2353 RTSGQPTSISVRINRSLIHKHRPDSIIRSVAEDQFYPLDIEVAVFNVVSKSPEHVSGGVPFLDPQISDRCRAALVPGQSIEHLDALDRHQQREKAFRQSRSRPFLLLIALGNMAIVYSEWFCYLLLVVNHMRSSNILSLVYPLVVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFITFNDPSLKPADSAEALWIPRLLGVEKSGHYAIFDLVQLISLFLHRGFLKNDGLWRDHTEFVQDLQLVAERNKVAERVQNGEQVGPDFLRLLSTESAASQMVEGHNVDAVTSGRLTVSRRDALHTWNPFAKLRRFYHKMTDPQFNKKVDVYIYMFLCEFISFWIIMFGYVSFGPSTGMGDNAFEFIRSNRVPFPFVCMLLVQFIFIIIDRGLFLRKQVLGKFIFQILHVLLIHGWLFFILPHITKSPFTAGFAPQLLYLIKCVYFSLSAYQIRSGYPLRILGNFLTKKYNYINLILFKGYLIVPFLYELRNIMDWMWTNSTLSLYHWMELEDVYAKIFVHKCWRRSEIAYPTPRGVNRPAGKKALVGGLILAFFFACLWIPLALSSFIGATFVFNPPVLCTFSLSIGGFPPVFEFTSREGNILKIRQQDLDSFTR-CHEKDLQTVGFLNNFEVDDLRYITIDGFSGNIWAITPPSYDTLVKKLSDASSDLLLHSHMQCRRKTKEIQTSQISVEDIFSRKLQPLEKIELYDVLNTTAVGSAANNTQVKLSSRVLSSSPVTLNAVMPRYLVLKRDRLRPAYATLGRENTYIN--VSFVIHRDPAKNQS-WWELKERAITSSDACFEKLRFPTLGDSWADALSIMTFNERVSDSLFGKWFFTYGILGMYGAYLFLVNRLFRTVYTNISYVIRLEELPHVDRILNLCNEIYLVRENKLLRLEEQLVAKLFFLYRSSETMIKWTRHPKRIIDQFTDR 3282 HSP 2 Score: 278.485 bits (711), Expect = 5.268e-71 Identity = 139/314 (44.27%), Postives = 206/314 (65.61%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN--NIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI-PTRENHISISI-ENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPN--EHYLVLRSGDYFLFEEHQEEDE 3224
L WLF+P P A KL D Q++ V LQY VFKIE ++ +Y GG N+P++ N +P E++DF+S K SY+DYL+ +IF W YW++L IV G+ TLFCLGYMIL+ +Y W+GQ +L RR L+ SWN+I+ YNF +IL KC+LQ+V CVY + + +CW I + G+ C+ P + + + C +++ +WDV+CFIF++ QRK+F T+SF +VV D+ + ++F SRGA LIN+KLM ++E+ +E K++EK+ I++ GR N EHY+++RSGDY+LFE EED+
Sbjct: 1207 LLQWLFVPGQYGSPTAKKLTADFFQFVAVALQYQVFKIEKRFSVKEYGGGSNKPVLINNVPGKEERDFVSAKESYLDYLRHLIFYWSYWVSLAIVLATGVTWITLFCLGYMILSFIYLWMGQNVMLRRRSSLIKSWNVIIGYNFCVILAKCSLQVVGCVYWARMSH--QCWFIQLFGVQCMDPMSWSRFEPPVYDKQCETVSSGLHWDVICFIFILFQRKVFMTQSFSHVVFDLNVQSQFASRGAYLINRKLMTDISEQLAREELSLAKIREKLAVIQRRQAVLGRNTDNITEHYIMIRSGDYYLFEGDPEEDD 1518 HSP 3 Score: 234.187 bits (596), Expect = 1.341e-57 Identity = 141/331 (42.60%), Postives = 191/331 (57.70%), Query Frame = 2
Query: 629 PFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRL-----------SVSSQIDRARS------SVIFE------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
P + S+ S +++SYI + IAMMAW+VTY+SWL+F+LL+ ACI+W+ P+SRAACL SP IV Y I+LI I YV +N K E++E G+ +W L L I +LV FWLTLRL++ E+ SV I R S + E DN+ ++ L LC KYWI C + +LL+SIQ+ V I + YM+ L+ M FF SY FWRRQM +WW+ +VYS+ +L IYT+QFK E W T ++E LKD G E FD ++L LL+PV+ L+V I+QVHYFH PF+K S L
Sbjct: 559 PLLLSLHFSAIRHSYIVTLIAMMAWAVTYRSWLSFILLLSACIVWISPNSRAACLYASPLIVLYAIVLILIQYVYGLNL-TTAELPKQVTPDGLEMAELGMKKWDNSVGALGLQITFLVFFWLTLRLFVNERSYRRFTTRSPTGYPSVGHPIGRGTSIWDRHLATSVESWFGSTFAFGTVDNTAYRRFTELLRALCVKYWIVVCCLSMLLISIQQPVVIFRIFYMVMLIYFMFFFQVSYGFWRRQMIFFWWINVVYSMAILLCIYTYQFKNSPEFWQRTTGLSEEVLKDIGLETFDSAALFARLLTPVLFLVVIILQVHYFHEPFLKRSAL 888 HSP 4 Score: 71.633 bits (174), Expect = 2.831e-8 Identity = 39/132 (29.55%), Postives = 65/132 (49.24%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE 2274
+ +F+ + + M FQL ++ C+ NK ++N + GL+K +F + + M +C WH I Y Q ++YN + +P +VFP T S+D+ L + VK +N+ FYK GLE
Sbjct: 1002 TIVFVWTGLFTLCKMCFQLNFVQ-LNVTIVCADSNK------TTHLENASWAGLVKVQNFNHYILPMGALMFVCVFWHAISYRQKQFYNSPHNLRPHEGVVFPDVTIASLDNDLRNVVKFAINYGFYKFGLE 1126
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A4S2LHK5 (Piezo-type mechanosensitive ion channel component OS=Opisthorchis felineus OX=147828 GN=CRM22_007115 PE=3 SV=1) HSP 1 Score: 703.745 bits (1815), Expect = 0.000e+0 Identity = 416/999 (41.64%), Postives = 596/999 (59.66%), Query Frame = 3
Query: 3582 DTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENEKRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVDETSQAQQ----FQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDI-ESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKG---FKDKFNI-----KEPEKKTN--------FNTLQTSSLTSRFI----------------------LLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSR-GDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-------------------TIPKKYAVLVKGLPRFLVATKTDFQDA-LVLGSENS-LNPLESYMIMLSIERSTSDWWQLHSH---KEFDCLSRNPFS------PDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
D ++++ W K + Y F L+ +D LI +N LTK R +R +E EKR +K +I T+ + L+I + + ++++ +H ++ + D + ++ +D + QQ F++S SR FLL++A+GN+ I+YS+ CY++LV+NHM S N+LSL+YPL VFLW MLS PRP+ +WIF+I YT++VI+IKY+FQF+FI + + + ++P LG+ K+ HYA+ DL+QL LFLHRG+LKN GLW+ F + K E+ N L T S S+ + PF +++FY + +++K+VDVY+YMF+CEFISF+II+ GY +FGP TG A +F++ +++P PF+ ML+ QFIFIIIDR LFLRK V+GK +FQI +V+LIH W+FF+ P I++S + A APQ LY KCVYF+LS+YQI+SGYPLRILGNFLTKKYNY+NL LFKGYL+VPFLYELRN+MDW+WT++ LSLYHWME+EDV+AKIFV KCWRRSE+ YPTPRG NR K LVGGL++ FFF C W PL L S IG+ FV NPP C +L GF ++E+ SR G++L+ D ++ + C++ ++ + F+ +FE DD+ + I S +IW+ITPP+ D +K L D + L+S ++C R + +T++ V+ F + L E+ E+ + + L +PR+LV + + A LG EN+ +N S++I ++ S WW+L C + F D F+ER+SD+LFG+ F YGI+G+Y AY+F+ +RL R VY+NISY+IR EELP+VDRIL L NEIYLVRENK+ RLEEQLVAKL F+YRS ETMI++TR + I+D+ D+
Sbjct: 2204 DDSNTPAAQQREEGCWSKFKAFCLVTYLFLLSSVDSLIYLLNGLTKHYRNIRRRIEREKRCVKLNVINNTQ--------------HPEQSPLDIEVAVFNVVSKSPEHVSGGVPFLDPQISD-----------RCRAALVPGQSIEHLDALDRHQQREKAFRQSRSRPFLLLIALGNMAIVYSEWFCYLLLVVNHMRSSNILSLVYPLVVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFITFNDPSLKPADSAEALWIPRLLGVEKSGHYAIFDLVQLISLFLHRGFLKNDGLWRDHTEFVQDLQLVAERNKVAERVQNGEQVGPDFLRLLSTESAASQMVEGHNVDAVTSGRLTVSRRDALHTWNPFAKLRRFYHKMTDPQFNKKVDVYIYMFLCEFISFWIIMFGYVSFGPSTGMGDNAFEFIRSNRVPFPFVCMLLVQFIFIIIDRGLFLRKQVLGKFIFQILHVLLIHGWLFFILPHITKSPFTAGFAPQLLYLIKCVYFSLSAYQIRSGYPLRILGNFLTKKYNYINLILFKGYLIVPFLYELRNIMDWMWTNSTLSLYHWMELEDVYAKIFVHKCWRRSEIAYPTPRGVNRPAGKKALVGGLILAFFFACLWIPLALSSFIGATFVFNPPVLCTFSLSIGGFPPVFEFTSREGNILKIRQQDLDSFTR-CHEKDLQTVGFLNNFEVDDLRYITIDGFSGNIWAITPPSYDTLVKKLSDASSDLLLHSHMQCRRKTKEIQTSQISVEDIFSRKLQPLEKIELYDVLNTTAVGSAANNTQVKLSSRVLSSSPVTLNAVMPRYLVLKRDRLRPAYATLGRENTYIN--VSFVIHRDPAKNQS-WWELKERAITSSDACFEKLRFPTLGDSWADALSIMTFNERVSDSLFGKWFFTYGILGMYGAYLFLVNRLFRTVYTNISYVIRLEELPHVDRILNLCNEIYLVRENKLLRLEEQLVAKLFFLYRSSETMIKWTRHPKRIIDQFTDR 3173 HSP 2 Score: 278.485 bits (711), Expect = 5.159e-71 Identity = 140/318 (44.03%), Postives = 207/318 (65.09%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN--NIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI-PTRENHISISI-ENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPN--EHYLVLRSGDYFLFEEHQEEDEYDDR 3236
L WLF+P P A KL D Q++ V LQY VFKIE ++ +Y GG N+P++ N +P E++DF+S K SY+DYL+ +IF W YW++L IV G+ TLFCLGYMIL+ +Y W+GQ +L RR L+ SWN+I+ YNF +IL KC+LQ+V CVY + + +CW I + G+ C+ P + + + C +++ +WDV+CFIF++ QRK+F T+SF +VV D+ + ++F SRGA LIN+KLM ++E+ +E K++EK+ I++ GR N EHY+++RSGDY+LFE EED+ R
Sbjct: 1207 LLQWLFVPGQYGSPTAKKLTADFFQFVAVALQYQVFKIEKRFSVKEYGGGSNKPVLINNVPGKEERDFVSAKESYLDYLRHLIFYWSYWVSLAIVLATGVTWITLFCLGYMILSFIYLWMGQNVMLRRRSSLIKSWNVIIGYNFCVILAKCSLQVVGCVYWARMSH--QCWFIQLFGVQCMDPMSWSRFEPPVYDKQCETVSSGLHWDVICFIFILFQRKVFMTQSFSHVVFDLNVQSQFASRGAYLINRKLMTDISEQLAREELSLAKIREKLAVIQRRQAVLGRNTDNITEHYIMIRSGDYYLFEGDPEEDDEMPR 1522 HSP 3 Score: 234.572 bits (597), Expect = 1.287e-57 Identity = 141/331 (42.60%), Postives = 191/331 (57.70%), Query Frame = 2
Query: 629 PFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRL-----------SVSSQIDRARS------SVIFE------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
P + S+ S +++SYI + IAMMAW+VTY+SWL+F+LL+ ACI+W+ P+SRAACL SP IV Y I+LI I YV +N K E++E G+ +W L L I +LV FWLTLRL++ E+ SV I R S + E DN+ ++ L LC KYWI C + +LL+SIQ+ V I + YM+ L+ M FF SY FWRRQM +WW+ +VYS+ +L IYT+QFK E W T ++E LKD G E FD ++L LL+PV+ L+V I+QVHYFH PF+K S L
Sbjct: 559 PLLLSLHFSAIRHSYIVTLIAMMAWAVTYRSWLSFILLLSACIVWISPNSRAACLYASPLIVLYAIVLILIQYVYGLNL-TTAELPKQVTPDGLEMAELGMKKWDNSVGALGLQITFLVFFWLTLRLFVNERSYRRFTTRSPTGYPSVGHPIGRGTSIWDRHLATSVESWFGSTFAFGTVDNTAYRRFTELLRALCVKYWIVVCCLSMLLISIQQPVVIFRIFYMVMLIYFMFFFQVSYGFWRRQMIFFWWINVVYSMAILLCIYTYQFKNSPEFWQRTTGLSEEVLKDIGLETFDSAALFARLLTPVLFLVVIILQVHYFHEPFLKRSAL 888 HSP 4 Score: 71.633 bits (174), Expect = 3.069e-8 Identity = 39/132 (29.55%), Postives = 65/132 (49.24%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE 2274
+ +F+ + + M FQL ++ C+ NK ++N + GL+K +F + + M +C WH I Y Q ++YN + +P +VFP T S+D+ L + VK +N+ FYK GLE
Sbjct: 1002 TIVFVWTGLFTLCKMCFQLNFVQ-LNVTIVCADSNK------TTHLENASWAGLVKVQNFNHYILPMGALMFVCVFWHAISYRQKQFYNSPHNLRPHEGVVFPDVTIASLDNDLRNVVKFAINYGFYKFGLE 1126
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: G7YE70 (Piezo-type mechanosensitive ion channel component OS=Clonorchis sinensis OX=79923 GN=CLF_105772 PE=3 SV=1) HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0 Identity = 386/843 (45.79%), Postives = 545/843 (64.65%), Query Frame = 3
Query: 4038 QAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDI-ESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKG----------FKDKFNIKE---------PE---------------KKTNFNTLQTSSLT-SRFILL---KPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSR-GDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEI-------------------ASLFTIPKKYAVLVKGLPRFLVATKTDFQDA-LVLGSENS-LNPLESYMIMLSIERSTSDWWQLHSH---KEFDCLSRNPFS------PDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
+ + F++S SR FLL++A+GN+ I+YS+ CY++LV+NHM S N+LSL+YPL VFLW MLS PRP+ +WIF+I YT++VI+IKY+FQF+FI + + + ++P LG+ K+ HYA+ DL+QL LFLHRG+LKN GLW+ ++ + E P+ ++ N + + + LT SR L PF +++FY + +++K+VDVY+YMF+CEFISF+II++GY +FGP TG A +F++ +++P PF+ ML+ QFIFII+DR LFLRK V+GK +FQI +V+LIH W+FF+ P I++S + A APQ LY KCVYF+LS+YQI+SGYPLRILGNFLTKKYNY+NL LFKGYL++PFLYELRN+MDW+WT++ LSLYHWME+EDV+AKIFV KCWRRSE+ YPTPRG NR K LVGGL++ FFF C W PL L S IG+ FV NPP C +L GF ++E+ SR G++L+ D ++ + C++ ++ + F+ +FE DD+ + I S +IW+ITPP+ D +K L D + L+S ++C R + +T++ V+ F + L E+ E+ S I L +PR+LV + + A LG E++ +N S++I ++ S WW+L C + F D F+ER+SD+LFG+ F YGI+G+Y AY+F+ +RL R VY+NISY+IR EELP+VDRIL L NEIYLVRENK+ RLEEQLVAKL F+YRS ETMI++TR + I+D+ D+
Sbjct: 2351 REKAFRQSRSRPFLLLIALGNMAIVYSEWFCYLLLVVNHMRSSNILSLVYPLVVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFITFNDPSLKPADSAEALWIPRLLGVEKSGHYAIFDLVQLISLFLHRGFLKNDGLWRDHTEFVQDLQLVAERNKVAERVQNGEQVGPDFLRLLSTESAASQMTERHNVDGVTSGRLTVSRRDALHTWNPFAKLRRFYHKMTDPQFNKKVDVYIYMFLCEFISFWIIMLGYVSFGPSTGMGDNAFEFIRSNRVPFPFVCMLLVQFIFIIVDRGLFLRKQVLGKFIFQILHVLLIHGWLFFILPHITKSPFTAGFAPQLLYLIKCVYFSLSAYQIRSGYPLRILGNFLTKKYNYINLILFKGYLIIPFLYELRNIMDWMWTNSTLSLYHWMELEDVYAKIFVHKCWRRSEIAYPTPRGVNRPAGKKALVGGLILAFFFACLWIPLALSSFIGATFVFNPPVLCTFSLSIGGFPPVFEFTSREGNILKIRQQDLDSFTR-CHEKDLQTVGFLNNFEVDDLRYITIDGFSGNIWAITPPSYDTLVKKLSDASSDLLLHSHMQCRRKTKEIQTSQISVEDIFSRKLQPLEKIELYGVLNTTAVGSAYNNTQVKPSSRVISSSPVTLNAVMPRYLVLKRDRLRPAYATLGLESTYIN--VSFVIHRDPAKNQS-WWELKERAITSSDACFEKLRFPTLGDSWADALSIMTFNERVSDSLFGKWFFTYGILGMYGAYLFLVNRLFRTVYTNISYVIRLEELPHVDRILNLCNEIYLVRENKLLRLEEQLVAKLFFLYRSSETMIKWTRHPKRIIDQFTDR 3189 HSP 2 Score: 236.884 bits (603), Expect = 2.351e-73 Identity = 162/449 (36.08%), Postives = 245/449 (54.57%), Query Frame = 2
Query: 629 PFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFE---PYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKI--RLSVSSQIDR-------ARSSVIFE--------------------DNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHHEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELN--------YLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIVVAI 1855
P + S+ S +++SYI + IAMMAW+VTY+SWL+F+LL+ ACI+W+ P+SRAACL SP IV Y I+LI I Y+ +N + T ++ + E++E G+ +W+I L L I +LV FWLTLRL++ E+ R + S R + I++ DN+ ++ L LC KYWI C + +LL+SIQ+ V I + YM+ L+ M FF SY FWRRQM +WW+ +VYS+ +L IYT+QF+ E W T ++E LKD G E FD ++L LL+PV+ L+V I+QVHYFH PF+K S L F+R +E++ + +ST+ Q+ + ++ + L K S+AK Y + D N A + + KLI + WR +E+H+ K++ + I
Sbjct: 445 PLLLSLHFSAIRHSYIVTLIAMMAWAVTYRSWLSFILLLSACIMWISPNSRAACLYASPVIVLYAIVLILIQYIYGLN----LTTAELPQQVTPDGLEMAELGMKKWEISVGALGLQITFLVFFWLTLRLFVNERSYRRYATRSPTGYPSVGHFVGRGTSIWDRHLATSFGSWFGSTFAFGTVDNTAYRRFTELLRALCVKYWIVVCCLSMLLISIQQPVVIFRIFYMVMLIYFMFFFQVSYGFWRRQMIFFWWINVVYSMAILLCIYTYQFRNSPEFWQRTTGLSEEVLKDIGLETFDSAALFARLLTPVLFLVVIILQVHYFHEPFLKRSALD----RFNR---------MYELRDL---ASTTPQQSADHAATLSPSTTSSLSKLLRSFAKRNRRPMPRQTLYFIEDVNSAFHTIVTKLIAWAISLTNCCWRFMEVHWIKVVALLI 873 HSP 3 Score: 72.4034 bits (176), Expect = 2.351e-73 Identity = 39/132 (29.55%), Postives = 65/132 (49.24%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE 2274
+ +F+ + + M FQL ++ C+ NK ++N + GL+K +F + + M +C WH I Y Q ++YN + +P +VFP T S+D+ L + VK +N+ FYK GLE
Sbjct: 907 TIVFVWTGLLTLCKMCFQLNFVQ-LNVTIVCADSNK------TTHLENASWAGLIKVQNFNHYILPMGALMFVCVFWHAISYRQKQFYNSPHNLRPHEGVVFPDVTMASLDNDLRNVVKFAINYGFYKFGLE 1031 HSP 4 Score: 278.87 bits (712), Expect = 3.690e-71 Identity = 144/343 (41.98%), Postives = 216/343 (62.97%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIEN--NIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI-PTRENHISISI-ENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPN--EHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNE 3311
L WLF+P P A KL D Q++ V LQY VFKIE ++ +Y GG N+P++ N +P +++DF+S K SY+DYL+ +IF W YW++L IV G+ TLFCLGYMIL+ +Y W+GQ +L +R L+ SWN+I+ YNF +IL KC+LQ+V CVY + + +CW I + G+ C+ P + + + C +++ +WDV+CFIF++ QRK+F T+SF +VV D+ + ++F SRGA LIN+KLM ++E+ +E L K++EK+ I++ GR N EHY+++RSGDY+LFE EE DD + S G K +I+ + E
Sbjct: 1112 LLQWLFVPGQYGSPTAKKLTADFFQFVAVALQYQVFKIEKRFSVKEYGGGSNKPVLINNVPGKDERDFVSAKESYLDYLRHLIFYWSYWVSLAIVLATGVTWITLFCLGYMILSFIYLWMGQNVMLRKRSSLIKSWNVIIGYNFCVILAKCSLQVVGCVYWARMSH--QCWFIQLFGVQCMDPMSWSRFEPPVYDKQCETVSSGLHWDVICFIFILFQRKVFMTQSFSHVVFDLNVQSQFASRGAYLINRKLMTDISEQLAREELLLAKIREKLAVIQRRQAVLGRNTDNITEHYIMIRSGDYYLFEGDPEE---DDEMPRSAPAKGGKKRKPPPKIQGSAPE 1449
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 388.652 bits (997), Expect = 2.483e-108 Identity = 224/595 (37.65%), Postives = 347/595 (58.32%), Query Frame = 3
Query: 4578 FITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLF-----TIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHK----EFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
++ +++F+ NL YS DVYV MF+ + + F IIV G+ AFG G L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ +++ Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ L+PFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P ++L GF I+ +++ L +++ +++ + N A+ F++++ D+T+ ++ S S+W+I+PP+K + L L +RN S + + NL + ++A L T K V +K + PR+L A +D L+ ++ + + E S +WW ++ K + + + N SP + + +IFS+++S G + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K+
Sbjct: 2106 YLPIRQFFYNLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHQGGADIT-SSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVVLVFGIHFWMFFILPGVTERRFSQNRIAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNTPLDVSVSLTLGGFQPIFTMSAQQKNLNSITSAKFDNFVKHFSKNSFAVQFLEAYVYQDLTVAHLEGSSNSMWTISPPSKKNLIGMLNQADSDFPLTMTWSIQRNLS-LGAKSEMATGKKIINLDKETKIQLAKLLIETNSTDAHKKPVCIKSIFPRYLRA-PSDSNAKLIEQLSTDID-----LFLNRAEDSNKEWWVVNQTKFGLLKLESVKIND-SP-RLELYIFSDQVSPPSLG-FLAGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTREKK 2689 HSP 2 Score: 124.02 bits (310), Expect = 1.640e-27 Identity = 109/362 (30.11%), Postives = 167/362 (46.13%), Query Frame = 3
Query: 2277 YPFHFPYLLED-----WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPI----------VFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI-----PTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKEN-----------------QLFTKVKEKILRIEQTHQNYGRPLPNEH---------------YLVLRSGDYFLFE 3203
YP+ FP + WLFLP + P + L+ D + + +LQ VF EN + G+N I V N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K LL W+ ++ YN +I +K L++C YID + S CWLI +L + C P + + ++ G I WD +CF FL++QR++F + F +VV D++ SRGA L ++ + E+EN Q F K KEK+L + Q + +P E V+RSGDY+LFE
Sbjct: 1085 YPWRFPSSTTNSNVIKWLFLPDFSTRPNSMFLLYDFMLLLSASLQRQVFDEENKAAVRLMAGDNVEICRDLDAASFSVHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKLLHYWDFLIAYNVFVITMKNIFSLLACGYIDSMQKNS-CWLIQLLSLACTIKEYTPPNTDRCDLP-KDEAGII-----WDSICFSFLLLQRRVFMSYYFLHVVADIRAGQILASRGAELFQASIVKAVRARLEEENKSMEQLKRQMDRIKTRQQKFKKGKEKMLSMTQESGDGQNLIPPEEEDDDDAFVFTFPTFLLSVVRSGDYYLFE 1433 HSP 3 Score: 110.538 bits (275), Expect = 1.792e-23 Identity = 66/171 (38.60%), Postives = 109/171 (63.74%), Query Frame = 3
Query: 4008 NNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDKFNIKEPEKKT 4520
N + + +E +++F K+ L A+ NL++ +S+M+ Y+++++NHMIS +M++L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F + N ++++ P+ P +G+ K + Y DL+QL LF HR LK HGLW D+ + K +K T
Sbjct: 1813 NKMFYDEELEGSERFYKTQPLGLQLCYALYNLLVAHSEMVSYLVIILNHMISASMVTLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFSF--FPFNQNMIDRNKPYHPPNIIGVEKKDGYVHYDLIQLLTLFFHRSILKCHGLW----DEDDPKAKKKDT 1977 HSP 4 Score: 108.997 bits (271), Expect = 5.041e-23 Identity = 94/326 (28.83%), Postives = 156/326 (47.85%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRL-YMKEKIRLS-VSSQIDR-------------------------ARSSVIFEDNSTFKSLVYFLHKLC----AKYWIFGCTICLLLVSIQK--QVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SY+ + IAMM WS+TY SWLTFV L+ +C LW++ D R ++ SPF+V YG +L+ + Y+ + + + + IF P SE + LL+ L+ LT R +KE+ LS V+ + ++ A E++ LV + KL KYWI+ C LVS + + + + YMM + + + + WRR + +W V+VY++ V+ IYT QF W T + E+L G + F+++ L + P L+V I+ +HYFH F++++D+
Sbjct: 396 IMKQSYVCALIAMMTWSITYVSWLTFVFLLWSCALWMVRDRRKYAMLTSPFMVAYGNLLLVLQYIWSF--ETLKDVPDIFKTPTVPFSELS------SKVLCLLSFWLLLRQTLTERQDKLKEEAVLSEVTVETEKKGETQTRPENKWFTGHKHFKIFVCFADEEKQVEEDGMENDLVQVVGKLVMAMLVKYWIYICGSMFFLVSFEDVDHIAMYKVFYMMMFLFCVAMYQVDFERWRRILKYFWMSVVVYTMLVVILIYTCQFTTSVPFWSKVTGVSTESLGKLGLKQFEVTELFRRIFIPTSFLLVCILHLHYFHEHFLELTDI 713
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 383.645 bits (984), Expect = 1.026e-106 Identity = 226/606 (37.29%), Postives = 352/606 (58.09%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESYM-------IMLSIERSTS------DWWQLHSHKEFDCLSRNPFSPDKT-----KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ +I +++F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ +++ M Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ + L+ +++ E+ + Y A+ F++++ +DVT + S S+W+I+PP++ M+ +L K+ + +RN S V V L R E+ +L + AV++K + P F+ A S+++ P++ I L ++RS + +WW + ++ ++ + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2234 LEIYIPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLKFMNSYNYIPGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLME-VLSKEDQFPVTMSWTIQRNLS-LGAKAEVAMDKHVTYLDTNTRQELINLLNGTRNKAVIIKEVFPCFIRAP-----------SDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2824 HSP 2 Score: 129.028 bits (323), Expect = 4.587e-29 Identity = 99/308 (32.14%), Postives = 159/308 (51.62%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRAR-SSVIFEDNST--------------FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
++K SYI + IAMMAWS+TY SWLTFV LI +C LW++ D R ++ SPF+V YG +LI + Y+ + E + + F + ++PF L I L+ FWL LR + E+ Q D + S + ED S L + + KYWI+ C VS + ++ + ++YMM + + + Y WR + +W ++VY++ VL IYTFQF+ +W N T ++E L+D G E F +++L + P L+V I+ +HYFH+ F++++D+
Sbjct: 520 IMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYAMLTSPFMVFYGNLLIVLQYIWSF---ETLTPVPGLF-----------LKKEVPFRELGSKILCLLSFWLLLRQALTER----RERQRDETQLSDIRVEDCSPEKEMEEEPGEQREMMDVLGSTVMAMLNKYWIYICGGMFFFVSFEGRIVMYKIIYMMMFLFCVALYQVHYERWRWMLKYFWMSIVVYTMLVLILIYTFQFESSIHVWSNMTGLSKEKLEDLGLEQFSVAALFTRIFIPTSFLLVCILHLHYFHDRFLQLTDI 809 HSP 3 Score: 119.013 bits (297), Expect = 5.127e-26 Identity = 64/155 (41.29%), Postives = 103/155 (66.45%), Query Frame = 3
Query: 4008 NNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
N + + +E ++++F S ++ L A+ N+++ +S+M+CY+++++NHMIS ++ +L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F ++ L+K PF P +G+ K E Y DL+QL LF HR LK HGLW
Sbjct: 1953 NRMFYDEELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQNIE-LDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLW 2106 HSP 4 Score: 115.546 bits (288), Expect = 6.277e-25 Identity = 85/308 (27.60%), Postives = 150/308 (48.70%), Query Frame = 3
Query: 2277 YPFHFPYLLED-----WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENN-IYKYKGGENRPIV----------FNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGR 3146
YP+ P D WL+LP + P + L+ D + +C +LQ VF+ E++ + G+N I N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L + +C YI ++ + CWLI + + C + C +++ WD +CF L++QR++F + F +VV D++ + SRGA L ++ + E+E + +K ++ RI+ Q + R
Sbjct: 1189 YPWRNPSSSMDSNVVKWLYLPDFRTKPNSLFLLYDFMLLLCASLQRRVFEEEDDSAVRLLAGDNVEICRDLDAASFSQHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKALVT-NHCWLIQLFSLACTIKGYSRPEQQANKQCELPSDEAGIIWDSICFASLLLQRRVFMSYYFLHVVADIRSSQVLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQKFKR 1489
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 379.022 bits (972), Expect = 2.556e-105 Identity = 227/609 (37.27%), Postives = 354/609 (58.13%), Query Frame = 3
Query: 4563 ILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEY-NYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGL-PRFLVATKTDFQDALVLGSENSLNPLESYM-------IMLSIERSTS------DWWQLHSHKEFDCLSRNPFSPDKT-----KFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
I L+ +I +++F+ NL YS DVYV MF+ + + F IIV G+ AFG + + L + ++P F++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P ++ +++ M Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ + L+ +++ E+ N + + A+ F++++ +DVT + S S+W+I+PP++ M+ +L K+ + +RN S V V L R E+ +L + AV++K + P F+ A S+++ P++ I L ++RS + +WW + ++ ++ + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE L AKLIF+YRS ETMI++TR K
Sbjct: 2085 ITLEIYIPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADIT-SSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLNLMCNICFFPQGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLME-VLSKEDQFPVTMSWTIQRNLS-LGAKAEVAMDKHVTYLDTNTRQELINLLNGTRNKAVIIKEVFPCFIRAP-----------SDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2678 HSP 2 Score: 130.568 bits (327), Expect = 1.336e-29 Identity = 106/349 (30.37%), Postives = 172/349 (49.28%), Query Frame = 2
Query: 557 KKNRFTEHIHNTETTATGMP-AISLPFIWSVITSLVK-------NSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRAR-SSVIFEDNST--------------FKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
K R ++ + +P A+S P + ++VK SYI + IAMMAWS+TY SWLTFV LI +C LW++ D R ++ SPF+V YG +LI + Y+ + E + + F + ++PF L I L+ FWL LR + E+ Q D + S + ED S L + + KYWI+ C VS + ++ + ++YMM + + + Y WR + +W ++VY++ VL IYTFQF+ +W N T ++E L+D G E F +++L + P L+V I+ +HYFH+ F++++D+
Sbjct: 421 KAERMDSSMYEIDPVQDELPGALSSPEKAERVNAVVKTFRFIMKQSYICALIAMMAWSITYVSWLTFVFLIWSCTLWMVRDRRKYAMLTSPFMVFYGNLLIVLQYIWSF---ETLTPVPGLF-----------LKKEVPFRELGSKILCLLSFWLLLRQALTER----RERQRDETQLSDIRVEDCSPEKEMEEEPGEQREMMDVLGSTVMAMLNKYWIYICGGMFFFVSFEGRIVMYKIIYMMMFLFCVALYQVHYERWRWMLKYFWMSIVVYTMLVLILIYTFQFESSIHVWSNMTGLSKEKLEDLGLEQFSVAALFTRIFIPTSFLLVCILHLHYFHDRFLQLTDI 751 HSP 3 Score: 118.242 bits (295), Expect = 7.708e-26 Identity = 64/155 (41.29%), Postives = 103/155 (66.45%), Query Frame = 3
Query: 4008 NNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
N + + +E ++++F S ++ L A+ N+++ +S+M+CY+++++NHMIS ++ +L+ P+ +FLWAMLS PRPS +W+ I+YT++ I+IKY FQF F ++ L+K PF P +G+ K E Y DL+QL LF HR LK HGLW
Sbjct: 1800 NRMFYDEELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQNIE-LDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLW 1953 HSP 4 Score: 115.161 bits (287), Expect = 8.184e-25 Identity = 85/308 (27.60%), Postives = 150/308 (48.70%), Query Frame = 3
Query: 2277 YPFHFPYLLED-----WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENN-IYKYKGGENRPIV----------FNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGR 3146
YP+ P D WL+LP + P + L+ D + +C +LQ VF+ E++ + G+N I N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L + +C YI ++ + CWLI + + C + C +++ WD +CF L++QR++F + F +VV D++ + SRGA L ++ + E+E + +K ++ RI+ Q + R
Sbjct: 1102 YPWRNPSSSMDSNVVKWLYLPDFRTKPNSLFLLYDFMLLLCASLQRRVFEEEDDSAVRLLAGDNVEICRDLDAASFSQHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKALVT-NHCWLIQLFSLACTIKGYSRPEQQANKQCELPSDEAGIIWDSICFASLLLQRRVFMSYYFLHVVADIRSSQVLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQKFKR 1402
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 355.525 bits (911), Expect = 4.037e-98 Identity = 226/595 (37.98%), Postives = 343/595 (57.65%), Query Frame = 3
Query: 4593 KFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTE----RTEIASLFTIPKKYAVLVKGL-PRFLVA---TKTDFQDALVLGSENSLNPLESYM-IMLSIERSTS-------DWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
+F+ N+ Y DVY MF+ + + F IIV G+ AFG + + A L + ++P F++ML+ QF ++IDRAL+LRK V+GKL+FQI V IH+W+FF+ P ++ +N Q YF KC+YF LS+YQ++ GYP RILGNFLTKKYN+LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL +WM VED++A IF++KC R +E +YP P+G + + KY +GGL++ F W PL+ S++ S+ V N P +T++ G+ ++ + + +Q ++ +YN++ + + +N VA+ F+ + +D+ I S S+W I+PP++ +K LL M L +R D TV + +++L R ++ASL + V V + P ++ A + L G E E Y + LS+ R S +WW + DC ++ + IF++++S G + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE+L +KLIF+YRS ETMI++TR K
Sbjct: 1900 RFFHNILHAEYRAATDVYALMFLTDVVDFIIIVFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIQFSTMVIDRALYLRKAVLGKLIFQIILVFGIHLWMFFILPAVTERMFNQNFVAQLWYFVKCIYFTLSAYQVRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSPADMTLRLAWNFQR---DLNKGGTVENTFDKHSINLEPGNPVRADLASLLVGNRTEPVRVPHMFPNYIRAPNGAEAKPVSQLYEGDE------EGYQNVTLSLMRDGSLNGSGAQEWWDISVA---DC-DQSSGACGVLPMIIFNDKVSPPSLG-FLAGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTREK 2479 HSP 2 Score: 149.828 bits (377), Expect = 1.921e-35 Identity = 115/356 (32.30%), Postives = 188/356 (52.81%), Query Frame = 2
Query: 485 EAIQNLALFTKSSSSQNTNAAVSQKK--NRFTEHIHNTETTATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGD-EIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKE---KIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
+ + + L + S Q +N +++ N +H T+A + V +++ SYI + IAMM WS+TY SWLTFVLL+ AC++W+L R ++ SPFI+ YG+ L + YV ++ + E+ + Y + + G+ P + L + + + FWL LR +K+ + + + + D+S K L + L AKYWI+ C ++VS ++ +VYM+ ++ M + YS WRR + +WWLV+ Y++ VL IYT+QF+ F + W N+T FT+E L D G E F +S L ++ P L+ I+Q+HYFH PFMK++DL
Sbjct: 324 DDTKQMLLASGESPGQESNPTNTKEHVTNGSGQHDLGLSTSAVQQEEEEDSALLLVGRMIMQQSYICALIAMMVWSITYHSWLTFVLLLWACLIWMLRARRHFAMLCSPFILLYGLGLCCLQYVWAMHLEPELPQHVG-----YMSLRQMGLDRATYPCLRLGAMLLFTLTFWLLLRQSVKDIFWRKKKQTAPLQEVTTGENTGRDDSILKLLGRVVMSLYAKYWIYVCGGMFIMVSFAGKLVGYKIVYMLLFLLCMCLYQVYYSLWRRLLKPFWWLVVAYTMLVLIAIYTYQFEDFPDYWRNFTGFTEEQLSDIGLETFKLSELFTSIMIPGFFLLACILQLHYFHKPFMKITDL 674 HSP 3 Score: 117.857 bits (294), Expect = 9.727e-26 Identity = 60/151 (39.74%), Postives = 103/151 (68.21%), Query Frame = 3
Query: 4023 VDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNA-LEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
++E ++ F S +R+ L+ A+ N++ +S++ CY I+V+N+ ++ +++SL+ P+ +FLWAML+ PRPS +W+ I+YT++++++KY+FQF F S+ L ++ PFF P LG+ KT++Y DLLQL LF HR L+ +GLW
Sbjct: 1590 IEELVHSRDFYSSQNRMLKLLFALYNVLACHSELACYFIIVLNNAVTASVISLVLPILIFLWAMLAVPRPSKSFWMTAIVYTEVMVVVKYLFQFGFFPWNSEYETRLNENKPFFPPRILGLEKTDNYIRYDLLQLLALFFHRSLLQRYGLW 1740 HSP 4 Score: 110.923 bits (276), Expect = 1.449e-23 Identity = 90/335 (26.87%), Postives = 152/335 (45.37%), Query Frame = 3
Query: 2361 GDVIQYMCVNLQYYVFKIEN-NIYKYKGGENR--PIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCI------PTREN--HISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNY--GRPLPNE----------------------------------HYLVLRSGDYFLFEEHQEEDE 3224
D + MC + Q+ VF+ E + GGEN P + LP +FI N SY+D +K ++F + +W L +VF G R ++F LGY++ + + G + ++ R L W+ ++ YN +I+ K L +++CV++ + CW+I + + C P N S+ +E + WD +CF FL++QR++F + F +V D++ + + SRG L ++ + K+ E + ++K + RI Q Y GR P+E H VL SGDY+LFE E+E
Sbjct: 1042 ADFLLLMCASQQWKVFENEKKEEWMVLGGENNDNPDPMDRLPFNPAPNFI-NCRSYLDMMKVLVFRYMFWFVLAVVFVTGSTRISVFGLGYLLASFFFLLFGTRLLIKRSCTRLLMWDCLIIYNVTVIISKNILSILACVFVAD-MQARFCWVIQLFSLVCTVKDYYDPASLNDKECSLPVEEA------GIIWDSICFFFLLLQRRVFLSFYFLHVTADLQASARQASRGFELFRASIIKNMRFHKQAEKKSIQQLKNSMQRIRDKQQKYKEGRK-PSEREEQPTESQEELERKQRKERKTSKHKEWHRPWIDHATVLHSGDYYLFESDSGEEE 1367
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 72.0182 bits (175), Expect = 2.867e-12 Identity = 35/129 (27.13%), Postives = 69/129 (53.49%), Query Frame = 3
Query: 5283 YLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNL 5666
Y +GGL++ F W PL+ S++ S+ V N P +T++ G+ ++ + + +Q ++ +YN++ + + +N VA+ F+ + +D+ I S S+W I+PP++ +K LL M L
Sbjct: 44 YGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSPADMTL 172
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009619.1 (pep scaffold:Pmarinus_7.0:GL484020:1370:4517:1 gene:ENSPMAG00000008693.1 transcript:ENSPMAT00000009619.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 91.6633 bits (226), Expect = 6.584e-21 Identity = 59/131 (45.04%), Postives = 83/131 (63.36%), Query Frame = 3
Query: 5937 STSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQ 6329
S ++WW L + DC R D + +FS+R+S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDR+LKL +I+LVRE +LEE L AKLIF+YRS ETMI++TR K+
Sbjct: 71 SHAEWWSLRQLRS-DCPGRRC---DDIRIIVFSDRVSPPSLG-FLAGYGILGLYASVVLVVGKFVREFFSGISHSIMFEELPNVDRVLKLCTDIFLVRETGELQLEEDLYAKLIFLYRSPETMIKWTREKE 196
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO30292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T173]) HSP 1 Score: 235.343 bits (599), Expect = 5.031e-66 Identity = 121/323 (37.46%), Postives = 193/323 (59.75%), Query Frame = 3
Query: 4749 LKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKN-----------------NVVALSFMKSFEPD-----DVTIMYISNVSESIWSITPPNKDLFMKSLLDKK 5651
++++ +P F+ ML++QF IIIDR L+LRK+V KL F +F + HV++F + P++++ + + F+Y F C+YF LS+YQ++SGYP RILGNFLTK Y + LF+G+ +PFL ELR+V+DW+ TDT L+LYHW+++ED++A I+VLKC+R SE + RG W ++K+ VGGLL+ + W PL+ S I S++ NPP TL G+ ++ +++ L+ +++ + + IK + N V + +F D V ++ I+ S SIW I+PP++ L M LL +K
Sbjct: 161 VEENVVPKTFLYMLLSQFFLIIIDRCLYLRKYVFAKLFFLLFLTVSFHVFMFIVVPYVTKRPFFKNIPAIFMYIFMCMYFGLSAYQVRSGYPTRILGNFLTKSYTLTSGVLFQGFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIKTQHPGLHQGADTQPPLQVAIIFNCVLKIQIDTFLADYHDRGTVVLVKITGNSSSIWQISPPSRQLMMHDLLGEK 483 HSP 2 Score: 73.559 bits (179), Expect = 5.979e-13 Identity = 34/74 (45.95%), Postives = 58/74 (78.38%), Query Frame = 3
Query: 6111 FVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQS 6332
++ + +R +++ISY I +E+P VD++LKL +I++VRE+K F+LEE L AKL+F+YRS ET+I++T+ K++
Sbjct: 505 WLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKYKRA 578
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM3]) HSP 1 Score: 134.035 bits (336), Expect = 8.060e-32 Identity = 123/424 (29.01%), Postives = 201/424 (47.41%), Query Frame = 3
Query: 3651 WKYYTFFLTCLDKLIIKINLLTKDIRYVRNILENE---KRLIKTRIITYTEGDWMGSYENSFFLYKNQGQTLEINIKLNAFLTQTEDHFQILYRVVELENIDVKLYYDKINKIDNEPHINNTNNVIFVD-ETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYV--FQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWK---GFKDKFNIKEPEKKTNF------------NTLQTSSLTSRF----------ILLKPFITVKKFYMNLASYRY-SKRVDVYVYMFICEFISFFIIVIGYEAF-GPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDR 4823
W YY +F +DK+I ++ ++KD R + + L++E KRL K R G Y S + +TL + E D + +K + ++ +V+ +D + + A ++ S R+ VA ++ ++D++CY+++++NHM+ +LS+ P VF+W MLS PRP+ YWI +I YTQ+VI+IKY+ FQFKFI+ + + +K+ P +GI + H + DLL L L+ HR LK HGLW+ D + EP N N +S + ++ + K +VK F + S VDVY MF C+FI F II+ + AF P + + ++++ +P F+ ML++QF IIIDR
Sbjct: 118 WIYY-YFAIAIDKVIDVLSDISKDYREIADQLKHERKEKRLEKLR---------RGRYSYSSL----RARTLAAS-------------------ASAAEVSDSDVIENKGSATSRSDEDADSWSVLNIDLDDTDASNWKHSHMRVARFSVAFVYALLAHTDIICYLLMILNHMVYACLLSMPLPFLVFMWGMLSIPRPTKRYWITVITYTQIVIVIKYLFKFQFKFINNCNSSDGPDKNDPLCPARIIGIERDSHTSAYDLLLLLALYFHRYSLKVHGLWRDKAAHDDHDELYEPPLSPNSPKSEPTPFAGSRNMAASSPDSEQYQSDVEDSGESLWNKICRSVKAFLNRIYDPEVGSGAVDVYAIMFACQFIIFIIILFSWSAFSSPEPQRQAQFVKIVEENVVPKTFLYMLLSQFFLIIIDR 508 HSP 2 Score: 120.553 bits (301), Expect = 1.786e-27 Identity = 53/141 (37.59%), Postives = 88/141 (62.41%), Query Frame = 3
Query: 5073 LFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIK 5495
L + + +PFL ELR+V+DW+ TDT L+LYHW+++ED++A I+VLKC+R SE + RG W ++K+ VGGLL+ + W PL+ S I S++ NPP TL G+ ++ +++ L+ +++ + + IK
Sbjct: 503 LIIIDRFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIK 643
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47372 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM6]) HSP 1 Score: 97.0561 bits (240), Expect = 5.298e-23 Identity = 50/139 (35.97%), Postives = 76/139 (54.68%), Query Frame = 2
Query: 1130 AKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR 1546
AKYWI C LLV +Q +V + + YM + ++ + S + WR + WW++++YS+ +L IYT+QF W N T + + L + G +SLL LL+P I+ +IQ+H+FH PFM M DL R
Sbjct: 8 AKYWILLCCGAFLLVGLQNEVSVYQIGYMAIFLFILICYQISITTWRLILRPLWWVMVIYSICILLIIYTYQFDNMPLYWHNATGLSDQWLYNLGLRQHTKASLLMELLTPTAFSIIIVIQLHFFHQPFMAMIDLRNAR 146
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM5]) HSP 1 Score: 84.3445 bits (207), Expect = 6.697e-17 Identity = 69/244 (28.28%), Postives = 118/244 (48.36%), Query Frame = 3
Query: 2301 LEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGE-NRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINY-SKCWLIHILGIHCIPTRENHISISIENSCGHINND---FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSR 3017
L WL+L P + L+GD Q + Q V+ +E + + E +R K DF+ N +++D+ K +F YW+TL +V+ ++F G+++ + W GQ L RK LL W + + YN++ +L K LQ+V+CV+ D++ Y S C + +L + C+ R + S + + D D CF FL+ Q +IFT++ F +VV D + ++ R
Sbjct: 126 LSHWLYLTDVSFPSDPKLLLGDFFQLLFACCQENVYGLERYSWTAEETEQSRQTRRGSRVKFSTPDFMWNI-TWLDFCKVTLFQHMYWVTLAVVYITVQSTVSIFNFGFILWCFFFLWHGQALYLQPRKKLLRLWKLFICYNYLTLLAKVCLQVVACVWQDYVTQYTSNCLPLQLLSMFCL--RNSTYSGKPQTGMDCVAPDDTGLAMDCACFTFLLTQYRIFTSEYFRHVVRDHREQSEMAYR 366
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47369 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM2]) HSP 1 Score: 73.1738 bits (178), Expect = 1.232e-15 Identity = 34/74 (45.95%), Postives = 58/74 (78.38%), Query Frame = 3
Query: 6111 FVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQS 6332
++ + +R +++ISY I +E+P VD++LKL +I++VRE+K F+LEE L AKL+F+YRS ET+I++T+ K++
Sbjct: 10 WLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKYKRA 83
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: piezo1 (piezo type mechanosensitive ion channel component 1 [Source:NCBI gene;Acc:101175341]) HSP 1 Score: 410.223 bits (1053), Expect = 3.209e-115 Identity = 291/808 (36.01%), Postives = 453/808 (56.06%), Query Frame = 3
Query: 4044 QQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVN-ALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGL-WKGFKD-----------------------KFNIKEPEKKTNFNTLQT-----SSLTSRFILLKPFITVK--------KFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTE----RTEIASLFTIPKKYAVLVKG-LPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERS-----TSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTR 6320
++F +S +RL L++A+ +L+ +S++LCY+I+V+N+++S +++S++ P+ VFLWAML+ PRPS +W+ I+YT++++++KY+FQF F S + KD PFF P LG+ KT++Y DLLQL LF HR L L K F+ KE E++ + + LT LK + ++K F+ NL ++ DVY MF+ + + F II+ G+ AFG + + A L + ++P F++ML+ F +IIDRAL+LRK V+GKL+FQ V+ IHVW+FF+ P ++ K+N Q YF KC+YF LS+YQI+ GYP RILGNFLTK + +LNLFLF+G+ LVPFL ELR VMDW+WTDT LSL +WM VED++A IF++KC R +E +YP P+G + + KY +GGL++ F W PL+ S++ S+ V N P +T++ G+ ++ + + +Q ++ +Y + +K+N A+ F+ + +D+ I S S+W I+PP++ +K LL ++ + L +R D TV ++ L R E+ASL + VLV P ++ A + + + + L +RS T +WW + C+ P S + IF++++S G L + YGI+G+Y + + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE+L +KLIF+YRS ETMI++TR
Sbjct: 1471 REFFESQNRLLKLLLALYSLLSAHSELLCYLIIVLNNVVSASVISVVLPILVFLWAMLALPRPSKRFWMTAIVYTEVMVVLKYIFQFGFFSWNSAHEMTVNKDRPFFPPRILGLEKTDNYLRYDLLQLLALFFHRALLMVCTLNLKSFRPDQEALLAKAAALRKKEALVPEEIHLRAKEEEEEMRLRAKKEQLELETDLTVASARLKVYESLKDVQSSPAQNFFKNLMHNKHQASTDVYALMFLTDMVDFVIIIFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIHFSTMIIDRALYLRKAVLGKLIFQGILVLGIHVWMFFILPSVTERKFNQNFVAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKNFGHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPIDVTVTVKLGGYEPLFTMSVQQQSIQPFNNSQYEELTKMFKDN-TAMQFITLYSYEDIVTAQIEGSSGSVWRISPPSRQEVIKELLGSQVDLTLRLAWNFQR---DLGKGGTVEHTFDKYSIDLEPGNLVRAELASLLIGNRTEPVLVPNFFPNYIRAPNGAEAKPVSQLYKGGEDGYLGITLSLKSDRSSNSSGTREWWDIAVE---GCV---PPSCGVLRMVIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTR 2266 HSP 2 Score: 171.785 bits (434), Expect = 4.792e-42 Identity = 123/403 (30.52%), Postives = 202/403 (50.12%), Query Frame = 2
Query: 656 LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNIN-GDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHH-EMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELNYLVYDANGAIY----ILTRXXXXXXXXXXXXXWRILEIHFTKIIV 1846
+++ SY+ + IAMM WS+TY SWLTFVLL+ AC++W+L R A + SPFI+ YG++L + Y+ + E+ ++ + + G+ + + P + L + +++ FWL LR + E R SSQ + ++ S K + + AKYWI+ C ++VS ++ +VYM+ ++ + F+ YS WR + ++WWLV+ Y++ VL IYT+QF+ F W N T FT E L G E FD+S L +L P L+ I+Q+HYFH PFM+++DL + R N + E+ S+T + + E K L+ G + +L+RK I + +WR+LE+H K++
Sbjct: 384 VMQQSYVSALIAMMVWSITYHSWLTFVLLLWACLIWILRARRHAATLCSPFILLYGLVLCCLQYIWAMELHPELPTSVGTM-----SLRQLGLDKAQYPCLRLGAMLLFVLTFWLLLRQAVMENFRRKSSSQTPLQEVATKGQNQSMLKVVGGMVMSCYAKYWIYVCGGMFIMVSFAGKLVAYKIVYMLLFLLCLCFYQVYYSLWRHLLKLFWWLVVAYTMLVLITIYTYQFEDFPVYWKNLTGFTDEQLAAIGLETFDLSELFTSILIPGFFLLACILQLHYFHKPFMRITDLENVTPTHKRRNSDAVGSADAVELNTEEDPSNTEESAD------------------EGRTQKTTKELMPSKWGLVMDRLLVLSRKFSEILSKVQVFLWRLLELHILKMVA 763 HSP 3 Score: 109.768 bits (273), Expect = 2.878e-23 Identity = 85/309 (27.51%), Postives = 153/309 (49.51%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIE-NNIYKYKGGEN----RPI---VFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPT----RENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLF 3200
WL+LP + P + L+ D + MC + Q+ VF E + GEN P+ +FN P +FI N SY+D LK ++F +F+W L +VF G R ++F LGY++ + G + ++ R + L W+ ++ YN +I+ K L +++CV++ + CW+I + + C R++ ++ IE + WD CFI L++QR++F + F +V +++ + K SRG L +M + K+ E++ +++K + L + V+ SG+Y+LF
Sbjct: 1028 WLYLPDFFTVPNSGNLMADFVLLMCASQQWKVFDCERTEEWMVLAGENSDEPEPMEGRLFNPAP-----NFI-NCRSYLDMLKVLVFRYFFWFVLSVVFITGASRISVFGLGYLLGCFFFLLFGTKLMVKRSRTRLILWDCLIIYNVAVIISKSVLSILACVFVFK-MQERFCWVIQLFSLVCTVKGYYDRDDTCTLPIEEA------GILWDGFCFICLLLQRRVFLSFYFLHVSAELQASAKQASRGFELFRASMMKNMDFHKQAEDKSLSQLKRS------------QTLMSCCAAVIHSGEYYLF 1311
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 372.474 bits (955), Expect = 2.275e-103 Identity = 225/600 (37.50%), Postives = 345/600 (57.50%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYM-------IMLSIERSTSD------WWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG ST+ L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P I+ ++N Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT+LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ L +N K A+ +++++ P+D+ I + S S+W+I+PP++D NL M+ + S V ++ +NLSL E A K VL + + L+ L+ G+ ++ N ++ I L+++R+ +D WW ++ ++ + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE + +KLIF+YRS ETMI++TR K
Sbjct: 2047 LEIYLPMKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFG--KHSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQL-------WNVTK-------TAIQWLENYTPEDLIIAELKGSSNSLWTISPPSRD-------------NLIDMLRSQEEFS------ITVSWSIQRNLSLGAEAESA----YGKNVMVLNQETKQNLI--------LLLNGAADAANTQVIFLTGNKMIDIHLTMQRAQNDSGQAQEWWIVNQTEQSIIPKIGRKHEAGLEIYVFSDQVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTREK 2598 HSP 2 Score: 139.043 bits (349), Expect = 4.281e-32 Identity = 143/542 (26.38%), Postives = 239/542 (44.10%), Query Frame = 2
Query: 137 FVYYYWHLIMTKMFLIGMVIILLVVSITFTLCHPIVHILIIFYPNFLKNCSSPYVLYMYQIGITKLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQ-----------NTNAAVSQKKNRFTEHIHNTET----------TATGMPA-----------------------ISLPFIWSVITS----------------------LVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIR--------LSVSSQIDRARSSVIFEDN--STFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
F+ +W L T LI + +L+ ++ H IV L F F + SP Y+ GI+ ++ + + SC SV ++++ F++P L L+Y + ++WL +E I +L + + + ++ NT A +++ N ++ N T T G P +SLP S ++K SYI + IAMMAWS+TY SWLTFV L+ +CILW++ D R ++ SPF+V YG ++I + Y + E + FF E K PF L + ++ FWL LR + E+ LS D+ + +E + F S+V + KYWI+ C VS + + + ++YMM + + + + +WRR + +W V++Y++ VL +YTFQF ++ W E+L D G E F +S+L + P L+V I+ +HYFH+ F++++DL
Sbjct: 275 FLCTWWSLCRTFNTLIFSCMCVLMA--IYSAGHIIVLYLYQF--QFFQESVSPQDEYIRVFGISPIV----QSNCSCTWKLSVHS-DRKWYHFVSPIMLLVLYYTLATLIRLWL-QEPIDHLMVSSADTPAEHQLNVPFLLFGNTCAFITETLNVISDDRQNGPTSNGTSLDFMATENGPPCLNFYSTPQYKMDQPEKKEECVYEVSLPPEDSAAKETEDEENDIKKKGVGAMVKVFHFVMKQSYICALIAMMAWSITYVSWLTFVFLMWSCILWMVRDRRRYAMMSSPFMVAYGNLIIVLQYFWSF---ERAKPVAGFF-----------VEKKNPFHSLSSKMLCMLSFWLLLRQTLTERQEKQKEESAGLSDVHVEDQKKKGKPYEQDIMHVFGSMVM---AVLVKYWIYICGGMFFFVSFEGNIVMYKIIYMMMFLSCVALYQVHFEYWRRILKYFWMSVVIYTMLVLTVVYTFQFDGSKDFWSGMLNVKNESLNDLGLEQFSVSTLFTRIFIPTSFLLVCILHLHYFHDHFLQLTDL 789 HSP 3 Score: 129.798 bits (325), Expect = 2.370e-29 Identity = 105/341 (30.79%), Postives = 172/341 (50.44%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIY-KYKGGENRPI----------VFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALL----INKKLMGILTEEKEKENQL-------------FTKVKEKILRIEQTHQNYGRPL-------------PNEHYLVLRSGDYFLFE 3203
WL++P + P+ LI D + +C ++Q VF+ EN + G+N I V N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L +++C YID ++ + CWLI + + C T + ++ I + ++C N+ WD +CF FL++QR++F + F +VV D++ + SRGA L I K + L EE + QL F + K+KIL + Q G+P+ P + V+RSGDY+LFE
Sbjct: 1154 WLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEICRDLDAASFSVHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLME-NNCWLIQLFSLSC--TIKGYV-IKL-DTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASQVLASRGAELFQATIVKAVKARLEEEHKSVEQLKRQMERIKVRQQKFKRGKDKILSLAQESAE-GQPVVQPEEDDDDGMVNPTPTHSVVRSGDYYLFE 1482 HSP 4 Score: 113.62 bits (283), Expect = 2.233e-24 Identity = 60/149 (40.27%), Postives = 97/149 (65.10%), Query Frame = 3
Query: 4026 DETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
+E Q+ F ++ + A+ N+++ +S+ +CY+++++NHM+S + +SL+ P+++FLWAMLS PRPS YW+ I+YT++ I+IKY QF F S L K++P++ +G+ K + Y L DL+QL LF HR LK HGLW
Sbjct: 1772 EELEQSDHFYQNQPLILQFSYALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGFFP-HSKNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLW 1919
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: ENSORLT00000004626.2 (pep primary_assembly:ASM223467v1:7:7477416:7483305:1 gene:ENSORLG00000003710.2 transcript:ENSORLT00000004626.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 339.732 bits (870), Expect = 1.360e-101 Identity = 203/588 (34.52%), Postives = 317/588 (53.91%), Query Frame = 3
Query: 4578 FITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLS--IERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQS 6332
++ +++F+ ++ YS DVY MF+ + ++F + + GY AFG + + + + L + ++P F++ML+ QF +I+DRAL+L+K ++GK VFQ+ V IH W+FF+ P ++ ++N Q YF KC+YF LS+YQIK GYP RILGNFLTK YNYLNLFLF+G+ +VPFL ELR VMDW+WTDT LSL W+ VED++A IFVLKCWR SE +YP P G + V KY +GG ++ W PL+ S++ S V N P + L G+ ++ MS E N + + A+ F+ ++E +D+ + I + + +WSI+P ++ ++ L I+ +LN+ S++ E T+ L G+ L + D L + P+ + S ++ WW + L+ + + +F++++S + G + +GI+G+Y + + V + +R ++ IS I EELP VDR+LKL +I++VRE LEE L KLIF+YRS ETMI+ TR K S
Sbjct: 23 YLPIRQFFYDIIHPEYSPVCDVYALMFLIDVVNFIVTIYGYWAFGKYS-AVADITESLSEDQVPEAFLVMLLMQFGTMIVDRALYLKKSLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNPIAQLWYFVKCIYFGLSAYQIKCGYPNRILGNFLTKNYNYLNLFLFQGFRMVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYANIFVLKCWRESEKKYPHPPGQKKKKVVKYGMGGFIIFALISIIWFPLLFMSLVQSAAGVTNQPVEVSIQLSIAGYEPLF----------TMSAQEQNLVASLFLLQ-SAMQFLMNYEAEDIIVAKIKSDASLLWSISPASRAAMIEEL---SISSHLNA--------------------------SISMNVEAVGEHTVKFNDKALKDGIVSMLKGNSSKPSDRPDLQALAFFRPMSIKLQQASGASDKEADQWWVVEECS--PVLTSSEPKCHSIEIVVFNDKVSPSSLG-FLAGHGIVGLYMSVVLVIGKFVREFFNGISRSIMFEELPCVDRVLKLCTDIFVVRETGEMELEETLFEKLIFLYRSPETMIKMTREKDS 566
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 358.992 bits (920), Expect = 3.588e-99 Identity = 226/611 (36.99%), Postives = 352/611 (57.61%), Query Frame = 3
Query: 4569 LKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIF-VRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSIT-PPNKDL--FMKSLLDKKITM--------NLNS--MIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPK----KYAVLVKGLPRFLVA-TKTDFQDALVLGSENSLNPLESYMIMLSIERSTSD------WWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLK 6326
L+ ++ +K+F+ NL YS DVYV MF+ + + F IIV G+ AFG ST+ L + ++P PF++M++ QF +++DRAL+LRK V+GK++FQ+ V IH W+FF+ P I+ ++N Q YF KC+YF LS+YQI+ GYP R+LGNFLTK YNY+NLFLF+G+ LVPFL ELR VMDW+WTDT+LSL W+ VED++A IF+LKCWR SE YP PRG + V KY +GG++++ W PL+ S++ S+ V N P +T+ GF I+ +++ L +N K A+ +++++ P+D+ I + S S+W+I+ P +L ++S + IT+ N++S M+ P + +V L++ + + F K + L K +PR++ A +K+D LG++ I L+++R+ +D WW ++ ++ + ++FS+++S G + YGI+G+YA+ + V + +R +S IS+ I EELP VDRILKL +I+LVRE LEE + +KLIF+YRS ETMI++TR K
Sbjct: 2161 LEIYLPMKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFG--KHSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQL-------WNVTK-------TAIQWLENYTPEDLIIAELKGSSNSLWTISPPSRDNLIDMLRSQEEFSITVSWSIQRYPNIDSPLMMFDHIIPHTLQLCLKKKKLFYVILLNIFQFLFVIFYFIFFKQNLFRKKTLTKLIPRYIRAPSKSDATSVEQLGNK-------MIDIHLTMQRAQNDSGQAQEWWIVNQTEQSIIPKIGRKHEAGLEIYVFSDQVSPPSLG-FLAGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTREK 2747 HSP 2 Score: 136.732 bits (343), Expect = 2.264e-31 Identity = 143/539 (26.53%), Postives = 238/539 (44.16%), Query Frame = 2
Query: 137 FVYYYWHLIMTKMFLIGMVIILLVVSITFTLCHPIVHILIIFYPNFLKNCSSPYVLYMYQIGITKLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQ-----------NTNAAVSQKKNRFTEHIHNTET----------TATGMPAI---SLP--------------------------------FIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNS-----------------TFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
F+ +W L T LI + +L+ ++ H IV L F F + SP Y+ GI+ ++ + + SC SV ++++ F++P L L+Y + ++WL +E I +L + + + ++ NT A +++ N ++ N T T G P + S P + V ++K SYI + IAMMAWS+TY SWLTFV L+ +CILW++ D R ++ SPF+V YG ++I + Y + FE ++ F + E K PF L + ++ FWL LR + E R + S V ED F S+V + KYWI+ C VS + + + ++YMM + + + + +WRR + +W V++Y++ VL +YTFQF ++ W E+L D G E F +S+L + P L+V I+ +HYFH+ F++++DL
Sbjct: 220 FLCTWWSLCRTFNTLIFSCMCVLMA--IYSAGHIIVLYLYQF--QFFQESVSPQDEYIRVFGISPIV----QSNCSCTWKLSVHS-DRKWYHFVSPIMLLVLYYTLATLIRLWL-QEPIDHLMVSSADTPAEHQLNVPFLLFGNTCAFITETLNVISDDRQNGPTSNGTSLDFMATENGPPCLNFYSTPQYKMDQPGDSTEDSAAKETEDEENDIKKKGVGAMVKVFHFVMKQSYICALIAMMAWSITYVSWLTFVFLMWSCILWMVRDRRRYAMMSSPFMVAYGNLIIVLQYFWS-------------FERAKPVAGFFV-EKKNPFHSLSSKMLCMLSFWLLLRQTLTE--RQEKQKEESAGLSDVHVEDQKKKEEEESKEEEEQDIMHVFGSMVM---AVLVKYWIYICGGMFFFVSFEGNIVMYKIIYMMMFLSCVALYQVHFEYWRRILKYFWMSVVIYTMLVLTVVYTFQFDGSKDFWSGMLNVKNESLNDLGLEQFSVSTLFTRIFIPTSFLLVCILHLHYFHDHFLQLTDL 729 HSP 3 Score: 128.642 bits (322), Expect = 5.675e-29 Identity = 105/354 (29.66%), Postives = 171/354 (48.31%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPI----------VFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALL----INKKLMGILTEEKEKENQL-------------FTKVKEKILRIEQTHQNYGRPL--PNE------------------------HYLVLRSGDYFLFE 3203
WL++P + P+ LI D + +C ++Q VF+ EN + G+N I V N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L +++C YID ++ + CWLI + + C + I ++ ++C N+ WD +CF FL++QR++F + F +VV D++ + SRGA L I K + L EE + QL F + K+KIL + Q G+P+ P E H ++RSGDY+LFE
Sbjct: 1100 WLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEICRDLDAASFSVHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLME-NNCWLIQLFSLSCT-IKGYVIKLASSDTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASQVLASRGAELFQATIVKAVKARLEEEHKSVEQLKRQMERIKVRQQKFKRGKDKILSLAQESAE-GQPVVQPEEDDDDGAQRTKAKPKKKQWWRPWVDHASMVRSGDYYLFE 1444 HSP 4 Score: 115.161 bits (287), Expect = 7.273e-25 Identity = 61/155 (39.35%), Postives = 100/155 (64.52%), Query Frame = 3
Query: 4008 NNVIFVDETSQAQQFQKSSSRLFLLIVAIGNLVIIYSDMLCYMILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLW 4472
N + + +E Q+ F ++ + A+ N+++ +S+ +CY+++++NHM+S + +SL+ P+++FLWAMLS PRPS YW+ I+YT++ I+IKY QF F S L K++P++ +G+ K + Y L DL+QL LF HR LK HGLW
Sbjct: 1877 NKMFYDEELEQSDHFYQNQPLILQFSYALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGFFP-HSKNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLW 2030
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 138.658 bits (348), Expect = 3.963e-32 Identity = 130/502 (25.90%), Postives = 223/502 (44.42%), Query Frame = 2
Query: 248 ILIIFYPNFLKNCSSPYVLYMYQIGITKLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQ-----------NTNAAVSQKKNRFTEHIHNTET----------TATGMPAIS-----------------------------------LPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDN-----------------STFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDL 1534
+L ++ F + SP Y+ GI+ ++ + + SC SV ++++ F++P L L+Y + ++WL +E I +L + + + ++ NT A +++ N ++ N T T G P ++ + + V ++K SYI + IAMMAWS+TY SWLTFV L+ +CILW++ D R ++ SPF+V YG ++I + Y + FE ++ F + E K PF L + ++ FWL LR + E R + S V ED F S+V + KYWI+ C VS + + + ++YMM + + + + +WRR + +W V++Y++ VL +YTFQF ++ W E+L D G E F +S+L + P L+V I+ +HYFH+ F++++DL
Sbjct: 253 VLYLYQFQFFQESVSPQDEYIRVFGISPIV----QSNCSCTWKLSVHS-DRKWYHFVSPIMLLVLYYTLATLIRLWL-QEPIDHLMVSSADTPAEHQLNVPFLLFGNTCAFITETLNVISDDRQNGPTSNGTSLDFMATENGPPCLNFYSTPQYKMDQPGDSTEDSAAKETEDEENDIKKKGVGAMVKVFHFVMKQSYICALIAMMAWSITYVSWLTFVFLMWSCILWMVRDRRRYAMMSSPFMVAYGNLIIVLQYFWS-------------FERAKPVAGFFV-EKKNPFHSLSSKMLCMLSFWLLLRQTLTE--RQEKQKEESAGLSDVHVEDQKKKEEEESKEEEEQDIMHVFGSMVM---AVLVKYWIYICGGMFFFVSFEGNIVMYKIIYMMMFLSCVALYQVHFEYWRRILKYFWMSVVIYTMLVLTVVYTFQFDGSKDFWSGMLNVKNESLNDLGLEQFSVSTLFTRIFIPTSFLLVCILHLHYFHDHFLQLTDL 729 HSP 2 Score: 107.457 bits (267), Expect = 1.220e-22 Identity = 76/248 (30.65%), Postives = 132/248 (53.23%), Query Frame = 3
Query: 2310 WLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNI-YKYKGGENRPI----------VFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINND--FYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTS 3014
WL++P + P+ LI D + +C ++Q VF+ EN + G+N I V N +P DFI + SY+D LK I+F + +W L I+F G R ++FC+GY++ + G + +L K +L W+ ++ YN +I +K L +++C YID ++ + CWLI + + C + I ++ ++C N+ WD +CF FL++QR++F + F +VV D++ + F S
Sbjct: 1089 WLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEICRDLDAASFSVHNPVP-----DFIHCR-SYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLME-NNCWLIQLFSLSC-TIKGYVIKLASSDTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASGSFAS 1328
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000080325.1 (SMESG000080325.1) HSP 1 Score: 1431.39 bits (3704), Expect = 0.000e+0 Identity = 741/741 (100.00%), Postives = 741/741 (100.00%), Query Frame = 3
Query: 4134 MILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
MILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK
Sbjct: 1 MILVMNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 741
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000080325.1 (SMESG000080325.1) HSP 1 Score: 1424.07 bits (3685), Expect = 0.000e+0 Identity = 737/737 (100.00%), Postives = 737/737 (100.00%), Query Frame = 3
Query: 4146 MNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
MNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK
Sbjct: 1 MNHMISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 737
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000080325.1 (SMESG000080325.1) HSP 1 Score: 1416.36 bits (3665), Expect = 0.000e+0 Identity = 734/734 (100.00%), Postives = 734/734 (100.00%), Query Frame = 3
Query: 4155 MISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYAXXXXXXXXXXXXHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDXXXXXXXXXXXXXXNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRXXXXXXXXXXXFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 6356
MISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK
Sbjct: 1 MISVNMLSLLYPLSVFLWAMLSTPRPSTFYWIFIILYTQLVILIKYVFQFKFIDIESDVNALEKDSPFFLPVFLGINKTEHYALIDLLQLFVLFLHRGYLKNHGLWKGFKDKFNIKEPEKKTNFNTLQTSSLTSRFILLKPFITVKKFYMNLASYRYSKRVDVYVYMFICEFISFFIIVIGYEAFGPGTGSTSTALDFLKDSKIPIPFILMLITQFIFIIIDRALFLRKHVIGKLVFQIFYVILIHVWIFFLNPFISRSKYNARMAPQFLYFFKCVYFALSSYQIKSGYPLRILGNFLTKKYNYLNLFLFKGYLLVPFLYELRNVMDWIWTDTALSLYHWMEVEDVFAKIFVLKCWRRSELEYPTPRGTNRWHVTKYLVGGLLMIFFFLCFWGPLVLGSVIGSIFVRNPPFHCKLTLEFDGFSKIYEYNSRGDMLQAMSDDEYNYIKDCYKNNVVALSFMKSFEPDDVTIMYISNVSESIWSITPPNKDLFMKSLLDKKITMNLNSMIECERNPSDTKTTKTVVDYTFVKNLSLTERTEIASLFTIPKKYAVLVKGLPRFLVATKTDFQDALVLGSENSLNPLESYMIMLSIERSTSDWWQLHSHKEFDCLSRNPFSPDKTKFFIFSERISDNLFGQLFSRYGIIGIYAAYIFVAHRLLRAVYSNISYIIRCEELPYVDRILKLLNEIYLVRENKMFRLEEQLVAKLIFVYRSDETMIRFTRLKQSILDEHMDK 734
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000080326.1 (SMESG000080326.1) HSP 1 Score: 915.605 bits (2365), Expect = 0.000e+0 Identity = 501/525 (95.43%), Postives = 505/525 (96.19%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTETTATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHHEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELNYLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIVVAISKYATSHFQQFLSCY 1900
++LLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTET ATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVLLILACILWLLPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR LHHEMKVISRESSTSRNQNNYLISIIAKLLSKLLHKKEDSYAKELNYLVYDANGAIYILTRKLIIIFKYIYYKIWRILEIHFTKII+VAISKYATSH + Y
Sbjct: 50 SRLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTETAATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVLLILACILWLLPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR-------------LHHEMKVISRESSTSRNQNNYLISIIAKLLSKLLHKKEDSYAKELNYLVYDANGAIYILTRKLIIIFKYIYYKIWRILEIHFTKIIIVAISKYATSHVSAYNGIY 561 HSP 2 Score: 879.782 bits (2272), Expect = 0.000e+0 Identity = 485/497 (97.59%), Postives = 489/497 (98.39%), Query Frame = 3
Query: 2241 PKLCIL*NGSRVYPFHFPYLLEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY 3731
P LC +VYPFHFPYLL+DWLFLPSYLNPPEA KLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWNIILFYNFIIILIKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTK+KEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEKSSYKVNKNKSNKIFFKKD+VVLNSEEHSSSESSISASPVNNSEDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY
Sbjct: 774 PLLC------KVYPFHFPYLLDDWLFLPSYLNPPEASKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWNIILFYNFIIILIKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKIKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEKSSYKVNKNKSNKIFFKKDYVVLNSEEHSSSESSISASPVNNSEDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY 1264 HSP 3 Score: 275.018 bits (702), Expect = 0.000e+0 Identity = 133/140 (95.00%), Postives = 135/140 (96.43%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLECILFIFLI 2298
SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE + +I
Sbjct: 580 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLEICFIVTVI 719
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000080326.1 (SMESG000080326.1) HSP 1 Score: 915.605 bits (2365), Expect = 0.000e+0 Identity = 501/525 (95.43%), Postives = 505/525 (96.19%), Query Frame = 2
Query: 326 TKLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTETTATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVXXXXXXXXXXXPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKRISFSR*NLETRNKLHHEMKVISRESSTSRNQNNYXXXXXXXXXXXXXXXXEDSYAKELNYLVYDANGAIYILTRXXXXXXXXXXXXXWRILEIHFTKIIVVAISKYATSHFQQFLSCY 1900
++LLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTET ATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVLLILACILWLLPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR LHHEMKVISRESSTSRNQNNYLISIIAKLLSKLLHKKEDSYAKELNYLVYDANGAIYILTRKLIIIFKYIYYKIWRILEIHFTKII+VAISKYATSH + Y
Sbjct: 50 SRLLGLYYKIDTSCERHGSVTILQQRFFDFMNPFALFALFYIHSLDSKIWLDREAIQNLALFTKSSSSQNTNAAVSQKKNRFTEHIHNTETAATGMPAISLPFIWSVITSLVKNSYIFSFIAMMAWSVTYKSWLTFVLLILACILWLLPDSRAACLVMSPFIVGYGIMLIFINYVTNINGDEIMNTIKIFFEPYFEISEFGIFEWKIPFIPLLLTIGYLVVFWLTLRLYMKEKIRLSVSSQIDRARSSVIFEDNSTFKSLVYFLHKLCAKYWIFGCTICLLLVSIQKQVKIIYLVYMMFLVILMTFFMFSYSFWRRQMYIYWWLVIVYSLGVLFGIYTFQFKIFQELWFNYTIFTQENLKDFGFEVFDMSSLLEGLLSPVILLIVTIIQVHYFHNPFMKMSDLTPKR-------------LHHEMKVISRESSTSRNQNNYLISIIAKLLSKLLHKKEDSYAKELNYLVYDANGAIYILTRKLIIIFKYIYYKIWRILEIHFTKIIIVAISKYATSHVSAYNGIY 561 HSP 2 Score: 875.159 bits (2260), Expect = 0.000e+0 Identity = 485/498 (97.39%), Postives = 489/498 (98.19%), Query Frame = 3
Query: 2241 PKLCIL*NGSRVYPFHFPYLLEDWLFLPSYLNPPEAYKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWXXXXXXXXXXXXXKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISIS-IENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKVKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEXXXXXXXXXXXXXXXXXXXXVVLXXXXXXXXXXXXXXXXXXXXXDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY 3731
P LC +VYPFHFPYLL+DWLFLPSYLNPPEA KLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWNIILFYNFIIILIKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISIS IENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTK+KEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEKSSYKVNKNKSNKIFFKKD+VVLNSEEHSSSESSISASPVNNSEDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY
Sbjct: 774 PLLC------KVYPFHFPYLLDDWLFLPSYLNPPEASKLIGDVIQYMCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYLKQIIFCWFYWLTLGIVFFNGIMRNTLFCLGYMILATVYFWVGQQFILSRRKYLLSSWNIILFYNFIIILIKCNLQLVSCVYIDHIINYSKCWLIHILGIHCIPTRENHISISSIENSCGHINNDFYWDVLCFIFLIIQRKIFTTKSFGYVVLDMKITNKFTSRGALLINKKLMGILTEEKEKENQLFTKIKEKILRIEQTHQNYGRPLPNEHYLVLRSGDYFLFEEHQEEDEYDDRIDDSFEFLKGFHGKSDEQIKHKSNEMLDYMLVNSIDDIKFKRNCSTQHFQFANNLLKNSVIPMPIARSHTEKSSYKVNKNKSNKIFFKKDYVVLNSEEHSSSESSISASPVNNSEDTIEKDSSEEDRSKYWKKEDSKIWKYYTFFLTCLDKLIIKINLLTKDIRY 1265 HSP 3 Score: 275.018 bits (702), Expect = 0.000e+0 Identity = 133/140 (95.00%), Postives = 135/140 (96.43%), Query Frame = 1
Query: 1879 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLECILFIFLI 2298
SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLE + +I
Sbjct: 580 SAIFILLSMQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSDFQPFAWSIAFNMILCSLWHVIKYHQIRYYNFNTSHKPEHKLVFPYFTFRSIDHRLTSAVKGFLNFAFYKMGLEICFIVTVI 719 The following BLAST results are available for this feature:
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30006368 ID=SMED30006368|Name=Piezo-type mechanosensitive ion channel component|organism=Schmidtea mediterranea sexual|type=transcript|length=6439bpback to top protein sequence of SMED30006368-orf-1 >SMED30006368-orf-1 ID=SMED30006368-orf-1|Name=SMED30006368-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=467bp MTKMFLIGMVIILLVVSITFTLCHPIVHILIIFYPNFLKNCSSPYVLYMYback to top protein sequence of SMED30006368-orf-2 >SMED30006368-orf-2 ID=SMED30006368-orf-2|Name=SMED30006368-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=105bp MKVISRESSTSRNQNNYLISIIAKLLSKLLHKKEDSYAKELNYLVYDANGback to top protein sequence of SMED30006368-orf-3 >SMED30006368-orf-3 ID=SMED30006368-orf-3|Name=SMED30006368-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=144bp MQMIANMMFQLIILENFEFKTNCSLKNKYFAKFTLDQMDNLEYIGLLKYSback to top protein sequence of SMED30006368-orf-4 >SMED30006368-orf-4 ID=SMED30006368-orf-4|Name=SMED30006368-orf-4|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1327bp MCVNLQYYVFKIENNIYKYKGGENRPIVFNELPKTEDKDFISNKNSYMDYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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