FMRFamide-activated amiloride-sensitive sodium channel

Overview
NameFMRFamide-activated amiloride-sensitive sodium channel
Smed IDSMED30006253
Length (bp)1378
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of FMRFamide-activated amiloride-sensitive sodium channel (SMED30006253) t-SNE clustered cells

Violin plots show distribution of expression levels for FMRFamide-activated amiloride-sensitive sodium channel (SMED30006253) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FMRFamide-activated amiloride-sensitive sodium channel (SMED30006253) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FMRFamide-activated amiloride-sensitive sodium channel (SMED30006253) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30006253

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30006253h1SMcG0007014 SmedASXL_010478SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30006253h1SMcG0007014 dd_Smed_v6_20268_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
body wall musculatureSMED30006253h1SMcG0007014 dd_Smed_v4_20268_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 59.6918 bits (143), Expect = 5.753e-9
Identity = 77/341 (22.58%), Postives = 137/341 (40.18%), Query Frame = 2
Query:   17 IHAQYINCYSYNLYENY------SRNTNTMELYFYLDQ-GIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHAC-KLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEG-KLCHDDQSDMKCKHQ-LDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCF 1009
            +  +Y NC+++N  E        S +   + L F ++Q    D+  L    +       G + +IH     P F+   +    G    + ++    VH+E P+G C+      +K+ N   SYS   C K    QH I KQCGC                 +P  + G  +  D Q    C    LD +  K +C     +        SC + C+   Y +  S SS+P++          A + L KK      ++  R+Y+  ++ K                 + IN  + N  + ++++ +S++  L+  GG   ++ G ++I+I+E+IE L   F
Sbjct:  200 VFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDA-------GIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECN----PNIKLQN-FSSYSTSGCLKECKAQH-IKKQCGC-----------------VPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNS-------SCPVSCEEIEYPATISYSSFPSQ---------KALKYLSKK------LNQSRKYIRENLVK-----------------IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNF 471          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 58.9214 bits (141), Expect = 1.305e-8
Identity = 77/335 (22.99%), Postives = 127/335 (37.91%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:  299 HPMYGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFD 575          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 58.9214 bits (141), Expect = 1.326e-8
Identity = 77/335 (22.99%), Postives = 127/335 (37.91%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:  322 HPMYGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFD 598          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 58.5362 bits (140), Expect = 1.955e-8
Identity = 77/335 (22.99%), Postives = 127/335 (37.91%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:  358 HPMYGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFD 634          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 55.0694 bits (131), Expect = 1.489e-7
Identity = 76/332 (22.89%), Postives = 126/332 (37.95%), Query Frame = 2
Query:   29 YINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:    2 YGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFD 275          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: asic-1 (Degenerin-like protein asic-1 [Source:UniProtKB/Swiss-Prot;Acc:O01635])

HSP 1 Score: 55.4546 bits (132), Expect = 7.020e-8
Identity = 67/302 (22.19%), Postives = 109/302 (36.09%), Query Frame = 2
Query:  161 SQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCH-DDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARR--LRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARE 1057
            ++ +G  + +H     P  +    +   G ++   +K+ + V    PYG C  +  KT        +Y+   C+   IQ  ++K CGC    +             P + E K C  DD    +C          I  + +V+++  K +  SC  PC+   Y    S S WP     +       A    L  K E    I+ Y E L                             NY   L  E E    ++ LS  GG   +W+G+++I+I EV       F  L ++ + K   AR+
Sbjct:  554 TEAAGVRLTVHATDEQPFPDTLGFSAPTGFVSSFGIKLKSMVRLPAPYGDC-VREGKTEDFIYTQKAYNTEGCQRSCIQKHLSKTCGCGDPRF-------------PPYRESKNCPVDDPYKREC----------IKNEMHVATRDSKKLGCSCKQPCNQDVYSVSYSASRWPAIAGDLSGCPLGMAAHHCLNYKREQGSMIEVYFEQL-----------------------------NYESLL--ESEAYGWSNLLSDFGGQLGLWMGVSVITIGEVACFFFEVFISLISSNRTKRRPARK 800          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: del-4 (DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P91835])

HSP 1 Score: 53.9138 bits (128), Expect = 1.593e-7
Identity = 69/359 (19.22%), Postives = 135/359 (37.60%), Query Frame = 2
Query:  161 SQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLP--CDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTAR-KRKHFSARELQIQNINQNNYWLGPDTEFQFISSVTPIHKANFILQEEDHKESDLSLYDSNSKHDII 1228
            ++ SG ++ IH +   P  +       PGT + + +          PYG C+ K+      Y    +Y+  AC    +Q  I   CGC    Y       S  SN  +++         S++ C   +D +        N +   + D++  C  P  C+I SY    ST+ WP+ ++ +P   +            +  +D Y+                      N + + I     N  ++ E    +  +F+S  GG   +++G+++IS +E + ++   F    T + +R      E+ I+    +            +  V    K         H++++  LY+ ++ HDI+
Sbjct:  223 TEASGVIIDIHMQDEIPYPDVFGYFAPPGTASSLGVSYVQTTRLSKPYGSCTTKTKLKTTHYTG--TYTVEACFRSCMQEKIIASCGCYYPAY-------SHASNTTQYVSCDNGVQTLSNLNC---VDLI--------NSADSTEFDVLTDCDCPQPCEIDSYGVTVSTAQWPSDSY-VPTECNPGGPSGPWDASGESCLDWYK---------------------ANTILIEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYLVLIFLVFFYCCTHKSRRAEIEQLEMDIKKAKDD------------VDQVAEKRKK--------HQKANAELYEMDTAHDIV 519          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 60.4622 bits (145), Expect = 4.152e-9
Identity = 67/284 (23.59%), Postives = 111/284 (39.08%), Query Frame = 2
Query:  170 SGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPK--TMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSD-MKCKHQL-DAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNC 1006
            + A +++H++ +FP      I   PGT T I + +    H E PY  C+          +Y +   SYS  +C     Q  + + CGC   +YP+ N +  +CSN           D   D + C + L D+V  +  C            +  C  PC+   Y+   S + WP+   Q  WI       L  + +    I   R   NG V                   + I    +N   + E E  ++   LS  GG    W+G +++ I+E  E++++C
Sbjct:  333 AAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGS-EYCSN-----------DKYPDWVPCYYGLRDSVADRESC------------ISLCQQPCNDTQYKMVISMADWPSAGAQ-DWI----FHVLSYEKDSSHNITVNR---NGIVR------------------LNIYFQEFNYRSITESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIIIDC 566          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 58.151 bits (139), Expect = 1.918e-8
Identity = 60/284 (21.13%), Postives = 102/284 (35.92%), Query Frame = 2
Query:  170 SGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPK--TMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSD-MKCKHQL-DAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNC 1006
            + A +++H++ +FP      I   PGT T I + +    H E PY  C+          +Y +   SYS  +C     Q  + + CGC   +YP+ N +  +CSN           D   D + C + L D+V  +  C            +  C  PC+   Y+   S + WP+   Q  W K +                                                    +N   + E E  ++   LS  GG    W+G +++ I+E  E++++C
Sbjct:  302 AAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGS-EYCSN-----------DKYPDWVPCYYGLRDSVADRESC------------ISLCQQPCNDTQYKMVISMADWPSAGAQEIWDKHD----------------------------------------------------FNYRSITESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIIIDC 509          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cdh12 (cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase;Acc:XB-GENE-982876])

HSP 1 Score: 50.0618 bits (118), Expect = 6.167e-6
Identity = 69/342 (20.18%), Postives = 131/342 (38.30%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTM-------ELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWP---TKTWQMPWIKSNAARRLRK---KPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLL 1000
            H  Y NCY++N  E  +   ++M       ++  Y+D+        D ++  + S  +GA +L+H +  +P        L+  T T I +++  +     PY  C+           +LYS  Y+   C     Q ++ + CGC   + P+ N    +C N   +     C+      K   Q   V +++ C+S            +C   C    +   RS + WP   ++ W +  +      +L K   K +L      Y++  + S+++S                     P YN+            + LS  GG   +W+  +MI ++E++E+  
Sbjct:  288 HPLYGNCYTFNSAERGNLLVSSMGGAEYGLKVVLYIDE--------DEYNPYL-STAAGAKILVHDQDEYPFIEDLGTELETATETSIGMQLTESTKLSDPYSDCTMDGSDVS--VENLYSKKYTLQICLNSCFQREMVRTCGCAHYDQPLPN-GAKYC-NYEEYPSWIYCY-----FKLYKQF--VQEELGCQS------------ACRESCSFKEWTLTRSLAKWPSLNSEQWMLRVLSWELGEKLNKNLTKNDLANLNIFYQDLNSRSISES---------------------PTYNI-----------VTLLSNFGGQLGLWMSCSMICVLEIVEVFF 565          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259])

HSP 1 Score: 58.151 bits (139), Expect = 1.155e-8
Identity = 69/339 (20.35%), Postives = 133/339 (39.23%), Query Frame = 2
Query:   17 IHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQL------SGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDM-KCKHQ-LDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCF 1009
            +  +Y NC+++N  EN  +N N + +      G    + LD    +           +G + +IH     P F+   ++   G    + ++    VH+E P+G C+      +K+ N   +YS + C        I + CGC                 LP  + G     D  +   C    LD + +K +C     +        SC + C+   Y +  S S++P++          A R L KK      ++  +EY+  ++                 + + IN  + N  + ++++ +S+   L+  GG   ++ G ++I+I+E+IE     F
Sbjct:  200 VFTEYGNCFTFNYGENI-QNKNKVSV-----SGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECN----PNIKLRN-FITYSTYGCLKECKARHIQRLCGC-----------------LPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHN-------SSCPVSCEETEYPATVSYSTFPSQ---------RATRFLAKK------LNQSQEYIRENL-----------------VNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNF 471          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259])

HSP 1 Score: 57.7658 bits (138), Expect = 1.374e-8
Identity = 69/339 (20.35%), Postives = 133/339 (39.23%), Query Frame = 2
Query:   17 IHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQL------SGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDM-KCKHQ-LDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCF 1009
            +  +Y NC+++N  EN  +N N + +      G    + LD    +           +G + +IH     P F+   ++   G    + ++    VH+E P+G C+      +K+ N   +YS + C        I + CGC                 LP  + G     D  +   C    LD + +K +C     +        SC + C+   Y +  S S++P++          A R L KK      ++  +EY+  ++                 + + IN  + N  + ++++ +S+   L+  GG   ++ G ++I+I+E+IE     F
Sbjct:  158 VFTEYGNCFTFNYGENI-QNKNKVSV-----SGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECN----PNIKLRN-FITYSTYGCLKECKARHIQRLCGC-----------------LPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHN-------SSCPVSCEETEYPATVSYSTFPSQ---------RATRFLAKK------LNQSQEYIRENL-----------------VNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNF 429          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 52.7582 bits (125), Expect = 7.834e-7
Identity = 70/340 (20.59%), Postives = 127/340 (37.35%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAV--VKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWP---TKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       N N   L+     G+ + + L   +       + S ++GA V++H +      +    N++PG  T I ++          YG C+ ++   + + N LY   Y++  C     Q ++ K+CGC  I YP     + FC  L +   G           C ++L A   +  + C S             C  PC + +Y+     S WP   ++ W    +       +  K      ++ + + LN   N                                E   +++ S LS  G   S+W G +++S+VE+ E++ +
Sbjct:  220 HPMYGNCYTFN-------NKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCT-ENGSDVPVKN-LYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPK-GVEFCDYLKQSSWG----------YCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTN-------------------------------SESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFD 496          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 52.373 bits (124), Expect = 8.560e-7
Identity = 70/340 (20.59%), Postives = 127/340 (37.35%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAV--VKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWP---TKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       N N   L+     G+ + + L   +       + S ++GA V++H +      +    N++PG  T I ++          YG C+ ++   + + N LY   Y++  C     Q ++ K+CGC  I YP     + FC  L +   G           C ++L A   +  + C S             C  PC + +Y+     S WP   ++ W    +       +  K      ++ + + LN   N                                E   +++ S LS  G   S+W G +++S+VE+ E++ +
Sbjct:  220 HPMYGNCYTFN-------NKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCT-ENGSDVPVKN-LYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPK-GVEFCDYLKQSSWG----------YCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTN-------------------------------SESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFD 496          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 52.373 bits (124), Expect = 9.130e-7
Identity = 74/337 (21.96%), Postives = 131/337 (38.87%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAV--VKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       N N   L+     G+ + + L   +       + S ++GA V++H +      +    N++PG  T I ++          YG C+ ++   + + N LY   Y++  C     Q ++ K+CGC  I YP     + FC  L +   G           C ++L A   +  + C S             C  PC + +Y+     S WP+   Q  WI            E+    + Y   +N   N   ++             +     NY  +   E   +++ S LS  G   S+W G +++S+VE+ E++ +
Sbjct:  301 HPMYGNCYTFN-------NKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCT-ENGSDVPVKN-LYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPK-GVEFCDYLKQSSWG----------YCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQ-DWIF-----------EMLSLQNNYT--INNKRNGVAKLN------------IFFKELNYKTN--SESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFD 577          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 5.877e-11
Identity = 75/365 (20.55%), Postives = 156/365 (42.74%), Query Frame = 2
Query:   23 AQYINCYSYN----LYENYSRNTNTMELYFYL--DQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYP-IDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIIC-----KSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKG---YIDAYREYLNGSVNKSFR-----------------XXXXXXXXXXXXXAVMINRPNYNVHL-----VEEKEV--LSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLL 1000
              Y NC+++N    L  + +   N + L F +  D  +P +  +  F +++    +G  V++H   + P+     I++ PG  + + LK   +     PYG C+      +K     Y Y+  AC  L  Q  I ++CGC +   P + ++N +FC  +  + E    H ++   + +     +    +      + N+++    ++   C  PC   SY    S S WP + +Q+     +A  R  K+    G   ++    EYL    + S +                  L+++ + ++    +  N    N++L     VE +++    L    +  GG   +W+G+++++I+E+IE+++
Sbjct:  203 GNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNILHS-AGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGIK----QYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQL-----SAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVI 557          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P55270|SCNNA_BOVIN (Amiloride-sensitive sodium channel subunit alpha OS=Bos taurus OX=9913 GN=SCNN1A PE=1 SV=2)

HSP 1 Score: 60.4622 bits (145), Expect = 1.936e-8
Identity = 75/340 (22.06%), Postives = 133/340 (39.12%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDI-INLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARR----LRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N+  L+     G+ + + L   +       + S ++GA V++H R   P F  D   NL+PG  T I +           YG C+ K+   + + N LY+  Y++  C     Q  + K+CGC  I YP  +  + FC +  +      C+    D     +L    K                   C  PC +  Y+   S S WP+ T Q  W+    +R+    ++ K +    ++ + + LN   N                                E   +++ + LS  G   S+W G +++S+VE+ E++++
Sbjct:  280 HPMYGNCYTFN-------DKNSSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHERDE-PAFMDDAGFNLRPGVETSISMSKEAVDRLGGDYGDCT-KNGSEVPVEN-LYNTKYTQQVCIHSCFQESMIKECGCAYIFYPRPD-GVEFC-DYRKHNSWGYCYYKLQDAFSSDRLGCFTK-------------------CRKPCSVTIYKLSASYSQWPSATSQ-DWVFQMLSRQNNYTIKNKRDGVAKLNIFFKELNYKSN-------------------------------SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIID 556          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q9NY37|ASIC5_HUMAN (Acid-sensing ion channel 5 OS=Homo sapiens OX=9606 GN=ASIC5 PE=1 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 2.763e-8
Identity = 77/341 (22.58%), Postives = 137/341 (40.18%), Query Frame = 2
Query:   17 IHAQYINCYSYNLYENY------SRNTNTMELYFYLDQ-GIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHAC-KLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEG-KLCHDDQSDMKCKHQ-LDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCF 1009
            +  +Y NC+++N  E        S +   + L F ++Q    D+  L    +       G + +IH     P F+   +    G    + ++    VH+E P+G C+      +K+ N   SYS   C K    QH I KQCGC                 +P  + G  +  D Q    C    LD +  K +C     +        SC + C+   Y +  S SS+P++          A + L KK      ++  R+Y+  ++ K                 + IN  + N  + ++++ +S++  L+  GG   ++ G ++I+I+E+IE L   F
Sbjct:  200 VFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDA-------GIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECN----PNIKLQN-FSSYSTSGCLKECKAQH-IKKQCGC-----------------VPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNS-------SCPVSCEEIEYPATISYSSFPSQ---------KALKYLSKK------LNQSRKYIRENLVK-----------------IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNF 471          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P37088|SCNNA_HUMAN (Amiloride-sensitive sodium channel subunit alpha OS=Homo sapiens OX=9606 GN=SCNN1A PE=1 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 6.269e-8
Identity = 77/335 (22.99%), Postives = 127/335 (37.91%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:  299 HPMYGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFD 575          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|H2Q5A1|SCNNA_PANTR (Amiloride-sensitive sodium channel subunit alpha OS=Pan troglodytes OX=9598 GN=SCNN1A PE=3 SV=2)

HSP 1 Score: 58.9214 bits (141), Expect = 6.653e-8
Identity = 77/335 (22.99%), Postives = 127/335 (37.91%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD-----VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYS--YSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLN 1003
            H  Y NCY++N       + N   L+     GI + + L   +       + S ++GA V++H +      +    NL+PG  T I ++          YG C+ K+   + + N LY   Y++  C     Q  + K+CGC  I YP    N+ +C        G   +  Q D    H L    K                   C  PC + SY+     S WP+ T Q  W+    +R+         Y    +      VN  F+ L                  NY  +   E   +++ + LS  G   S+W G +++S+VE+ E++ +
Sbjct:  322 HPMYGNCYTFN-------DKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCT-KNGSDVPVEN-LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQ-NVEYCDYRKHSSWGYCYYKLQVDFSSDH-LGCFTK-------------------CRKPCSVTSYQLSAGYSRWPSVTSQE-WVFQMLSRQ-------NNYTVNNKRNGVAKVNIFFKEL------------------NYKTN--SESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFD 598          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4S2L707 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009422 PE=3 SV=1)

HSP 1 Score: 333.954 bits (855), Expect = 3.200e-106
Identity = 174/369 (47.15%), Postives = 249/369 (67.48%), Query Frame = 2
Query:    2 R*RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQS-----------------DMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYL---NGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHF 1045
            R R  +HAQY+NCYSY+L E Y  +  T+EL+ YLD     + C+DCFS+++KSQLSGA+V++H   T+P+ N + IN+QPG+LTEIK+K   ++ K PPYGRCS  +PKT+++Y    Y YSEHAC++ TIQ  IN +CGCNAIE+P  + +L FC  +  F+    C D QS                   +C  +L+ V   + CKS+V+  ++ D+V SC+LPC  +SYE+DRSTS+WPTK+WQ+ W+ + A R +  +PEL  Y +A R+ +   NG V ++  +L+Q N+LE+NLLA+MI RPN+N+H VEEKEVLSLTS LSQ GGL SIWIG+ ++S++E+ E+L++ F   K    RK+ 
Sbjct:   44 RWRRFVHAQYLNCYSYDLLEKYRDHVRTIELFVYLDVPPNKTSCVDCFSAEIKSQLSGAVVVVHNADTYPDINQEGINIQPGSLTEIKVKTIKHIQKTPPYGRCSPDTPKTIELYGAAPYRYSEHACRMSTIQTQINDRCGCNAIEFPYRSSSLPFCLAMGSFVHEGSC-DVQSLQGSGSKVANSTKIGSLKSECLAELEVVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRMILNRPELAPYREA-RDLMRQPNGDV-RAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHLFGTCKQPENRKNM 409          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G7Y609 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_101553 PE=3 SV=1)

HSP 1 Score: 332.798 bits (852), Expect = 4.427e-106
Identity = 172/364 (47.25%), Postives = 247/364 (67.86%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLC--HDDQSD--------------MKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYL---NGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRK 1039
            R  +HAQY+NCYSY+L E +  +  T+EL+ YLD     + C+DCFS+++KSQLSGA+V++H   T+P+ N + IN+QPG+LTEIK+K   ++ K PPYGRCS  +PKT+++Y    Y YSEHAC++ TIQ  IN +CGCNAIE+P  N +L FC  +  F+    C     Q+D               +C  +L+ V   + CKS+V+  ++ D+V SC+LPC  +SYE+DRSTS+WPTK+WQ+ W+ + A R +  +PEL  Y +A R+ +   NG V ++  +L+Q N+LE+NLLA+MI RPN+N+H VEEKEVLSLTS LSQ GGL SIWIG+ ++S++E+ E+L++ F   K    RK
Sbjct:   32 RRFVHAQYLNCYSYDLLEKFRDHVRTIELFVYLDVPPNKTSCVDCFSAEIKSQLSGAVVVVHNADTYPDINQEGINIQPGSLTEIKVKTIKHIQKTPPYGRCSPDTPKTIELYGAAPYRYSEHACRMSTIQTQINDRCGCNAIEFPYRNSSLPFCLAMGSFVHEGSCDVQKLQADGSKATNSTTIGSLKSQCLAELEVVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRMILDRPELAPYREA-RDLMRQPNGDV-RAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHLFGTCKQPENRK 393          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A158QSX4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS1629 PE=3 SV=1)

HSP 1 Score: 335.495 bits (859), Expect = 1.243e-105
Identity = 175/384 (45.57%), Postives = 258/384 (67.19%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLC-HDD--------------QSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKS----FRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARELQ----IQNINQNN 1087
            R   HA Y+NC+S++L  + S+   T+EL+ YL++   D  C DCF+S++KSQLSGA+V++H   T+P+ N + IN+QPGTLTEIK+K   N+ KEPPYGRCS  +P  +  Y+++ Y+YSE+ C++LTIQ++INK C CNAIE+P  +  L FC ++  F++   C ++D              +  + C+ QL+    +I+CK+ V  ++Q D+V +C+LPC  YSYE+DRSTS+WPTK+WQ+ W+K+   R + + PE+  Y  A  E L+   +K+     RIL + N +E+NLLA+M+ RPN+N+H V EKEV SLTSFLSQAGGL SIWIGLTMI +VEVIE+++NC +  K  R+ +      LQ    ++ +NQN+
Sbjct:  193 RHFFHALYLNCHSFDLDPSISQQVLTVELFSYLNERHDDVECHDCFASEIKSQLSGAVVVVHTAKTYPDVNQEGINVQPGTLTEIKIKAIENIQKEPPYGRCSLDTPTEIPSYDNISYAYSEYGCRMLTIQNEINKNCNCNAIEFPRMDDTLPFCMSMVDFVKENRCVYEDMVKQAQALNATGPSEEFLLCEKQLNMARDRILCKAQVMHRFQSDVVPTCTLPCAFYSYETDRSTSTWPTKSWQLTWLKTPIGRTILQMPEMSEYRRA-EELLDQPGDKNRDEVLRILAENNAVERNLLAIMVVRPNFNLHKVAEKEVFSLTSFLSQAGGLLSIWIGLTMICLVEVIELIINCINVFKAKRRDRRHDRLALQQHKNVKYVNQNS 575          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4V3SD10 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009422 PE=3 SV=1)

HSP 1 Score: 334.724 bits (857), Expect = 1.636e-104
Identity = 174/369 (47.15%), Postives = 249/369 (67.48%), Query Frame = 2
Query:    2 R*RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQS-----------------DMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYL---NGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHF 1045
            R R  +HAQY+NCYSY+L E Y  +  T+EL+ YLD     + C+DCFS+++KSQLSGA+V++H   T+P+ N + IN+QPG+LTEIK+K   ++ K PPYGRCS  +PKT+++Y    Y YSEHAC++ TIQ  IN +CGCNAIE+P  + +L FC  +  F+    C D QS                   +C  +L+ V   + CKS+V+  ++ D+V SC+LPC  +SYE+DRSTS+WPTK+WQ+ W+ + A R +  +PEL  Y +A R+ +   NG V ++  +L+Q N+LE+NLLA+MI RPN+N+H VEEKEVLSLTS LSQ GGL SIWIG+ ++S++E+ E+L++ F   K    RK+ 
Sbjct:  215 RWRRFVHAQYLNCYSYDLLEKYRDHVRTIELFVYLDVPPNKTSCVDCFSAEIKSQLSGAVVVVHNADTYPDINQEGINIQPGSLTEIKVKTIKHIQKTPPYGRCSPDTPKTIELYGAAPYRYSEHACRMSTIQTQINDRCGCNAIEFPYRSSSLPFCLAMGSFVHEGSC-DVQSLQGSGSKVANSTKIGSLKSECLAELEVVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRMILNRPELAPYREA-RDLMRQPNGDV-RAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHLFGTCKQPENRKNM 580          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A564Y5L5 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS2931 PE=3 SV=1)

HSP 1 Score: 325.094 bits (832), Expect = 2.251e-101
Identity = 175/385 (45.45%), Postives = 254/385 (65.97%), Query Frame = 2
Query:    2 R*RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDL-YSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQ---------------SDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGS--VNKS-----FRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNC---FSQLKTARKRKHFSAREL---QIQ 1069
            R R I+HA Y+NC++ ++  N S    ++EL+ YL++   + +C DCF++D+KSQLSGA++++H   T+P  N + IN+QPGTLTEIK K   N+ KEPPYGRC   +   +  ++   Y+YSE+ C++ TIQ +INK+C CNAIE+PI N +L FC ++  F++  +C+ +Q                 + C+ QL+   +K+ICKS V+ +YQ D+V +C+LPC  YSYE+DRSTS+WPTK+WQ+ W+ ++  R + +  E+  Y  A  E LN S  VNK+      RIL Q N LE+NLLA+ + RPN+N+H V EKEVLSLTSFLSQ GGL SIWIGLTMI +VE++E+++NC   F   +   +    S++EL   QIQ
Sbjct:  191 RWRRILHALYLNCHTLDVDPNISHRAVSLELFSYLNERHDEVICHDCFAADIKSQLSGAVIVVHSAQTYPEINKEGINVQPGTLTEIKFKAIENIQKEPPYGRCDRDTKTEIPSHDGASYAYSEYGCRMYTIQDEINKKCNCNAIEFPIVNGDLPFCMSMVDFVKEDMCNHEQMVKSVQMPNSTEPSNEFLVCEQQLNTAREKLICKSQVTGEYQGDVVPACTLPCSFYSYETDRSTSTWPTKSWQLAWLNTSIGRTVLQMSEMSEYRRAL-ELLNQSSDVNKTTTREILRILEQNNALERNLLAITVVRPNWNLHKVAEKEVLSLTSFLSQTGGLLSIWIGLTMICVVEILELIINCCYVFMFKRRENQEHRISSKELASPQIQ 574          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 46.9802 bits (110), Expect = 6.540e-6
Identity = 65/340 (19.12%), Postives = 125/340 (36.76%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSD---VKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPK--TMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWI------KSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNC 1006
            H  Y NCY++N     S N++ +       +    S+ L    +D     S ++GA +++H + + P       +++PG  T + +++        PYG C+        + +Y+  Y+     C     Q  + + CGC    YP+   N S+CS           ++      C ++L    ++ I         +   V  C+ PC    +      ++WP  +    WI      ++N +    +    K             +N  FR                      N+  + E    ++   LS  G   S+W G +++S +EV E+ ++C
Sbjct:  235 HPTYGNCYTFN-----SANSSKLWQASKPGRDYGLSLILRTEQNDYIPFLSTVAGARIMVHDQESPPFMEEGGFDMRPGFETSLGIRMLEATRMPDPYGNCTEDGSNVPVLNLYSSAYTVQVPECSCF--QLALVEACGCGYYFYPLPP-NASYCSY----------NNTAWAGHCYYKL---YRQFISD-------ELGCVDKCAQPCTTKRFAVTPGYAAWPDSS-SEKWIFNLLSLQNNYSVTTVRNDVAK-------------LNVYFR--------------------ELNMKTISESAATNVIWLLSNIGSQWSLWFGSSVLSWLEVGELGIDC 512          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000044381.1 (SMESG000044381.1)

HSP 1 Score: 814.683 bits (2103), Expect = 0.000e+0
Identity = 407/407 (100.00%), Postives = 407/407 (100.00%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARELQIQNINQNNYWLGPDTEFQFISSVTPIHKANFILQEEDHKESDLSLYDSNSKHDII 1228
            RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRILNQQNILEQNLLAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARELQIQNINQNNYWLGPDTEFQFISSVTPIHKANFILQEEDHKESDLSLYDSNSKHDII
Sbjct:  198 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRILNQQNILEQNLLAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARELQIQNINQNNYWLGPDTEFQFISSVTPIHKANFILQEEDHKESDLSLYDSNSKHDII 604          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000028687.1 (SMESG000028687.1)

HSP 1 Score: 410.223 bits (1053), Expect = 4.487e-138
Identity = 207/360 (57.50%), Postives = 265/360 (73.61%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKRKHFSARELQIQNINQNN 1087
            R IIHAQY+NCY ++L E+ S  TNT+E++ YLD+ I  + C+DCFSSDVKSQLSGAL+LIHR  TFPNFN D+INLQPGTLTEIKLK  +N HK PPYGRCS K+PK +K++ +LY+YSE  CKL+TIQ D+N  C CNAIEYP +  +L FCS LP F +   C++  +D KC+ +L   VK+I CK+     Y  DIV SC LPC  YSYE+DRSTS+WPTK+WQ+ WI + AA+ L  K EL  Y  A +    G+ +++ +ILN++N +EQ +LAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGL SIWIG+T+ SIVE+ EM  NCF + +    +  F+  + Q  ++N+ N
Sbjct:  222 RRIIHAQYVNCYMFDLIESLSNATNTLEMFLYLDESINQATCIDCFSSDVKSQLSGALILIHRSNTFPNFNRDMINLQPGTLTEIKLKTIHNRHKLPPYGRCSNKTPKWIKVFGELYAYSEDLCKLITIQGDLNHFCNCNAIEYPFNYSSLKFCSALPSFSQRVSCNNRLNDRKCETELKNTVKQISCKAKACLIYNNDIVPSCKLPCSFYSYETDRSTSTWPTKSWQLQWISTKAAKPLLDKQELDNYRYAVKLQEKGNYSEALKILNKENTMEQKILAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLFSIWIGMTLFSIVEIFEMFANCFWRFRKMFVKNGFTNDKNQASSLNEKN 581          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000069611.1 (SMESG000069611.1)

HSP 1 Score: 357.066 bits (915), Expect = 2.290e-117
Identity = 183/334 (54.79%), Postives = 239/334 (71.56%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHD---DQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLL 1000
            +V  HAQ+INC+SYN+   +     T+ELY YL++    S C+DCF S+VKSQLSGAL++IH+  +FPN N + INLQPGTLTE++LK F NV K  PYGRC   +P  +++ N+ YSY+EH CK  TIQ +IN +C CNAIEYP+ N NLSFCS LP FI+   C     D+   KC  ++   +K++ CKS+V+  Y  DI+ +C LPC+ YSYESDRS S+WPTK+WQ+ W+ S+    +R K ELK Y  A   +  G  +K+  ILN+Q+ILE  L+AV+INRPN N+H VEEKEVLSLTSFLSQ GGL SIWIGLT+ISIVE+IE+L+
Sbjct:  231 KVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPTFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGKEDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 564          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000064187.1 (SMESG000064187.1)

HSP 1 Score: 325.479 bits (833), Expect = 1.809e-105
Identity = 165/336 (49.11%), Postives = 236/336 (70.24%), Query Frame = 2
Query:    8 RVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQS-DMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARR--LRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNC 1006
            R  IHAQY+NC+++++      N  T+E++ YLD+ +  + C+DCF +++KSQLSGA++ +H   TFPN N   IN+ PG+LTEI L+   N+ K PPYGRCS K+PKT+ +Y    SYSE AC+ +TIQ++I K+CGC AIEYP  + ++ FCS++P F+  + C    + +  C  Q+   + +I CK +V +QY KD+V+SCSLPC  +SYE+DRS S+WPTK WQ+ W+ S  A+   +  + E + Y         G   ++  +L Q N+LE+NLLA++I+RPN+N+H VEEKEVLSLTSFLSQ+GGL SIW+GLTMIS+VEVIE+L+NC
Sbjct:  225 RQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDIPFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKISVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNSRVAKSFGMLNRTEFQPYRRIIELQKVGKEKEAMDLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLVEVIELLVNC 560          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000078360.1 (SMESG000078360.1)

HSP 1 Score: 322.783 bits (826), Expect = 2.163e-103
Identity = 167/344 (48.55%), Postives = 230/344 (66.86%), Query Frame = 2
Query:   20 HAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQS-----DMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRXXXXXXXXXXXXXAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARKR 1036
            HA YINC+S  +Y     +  ++ +Y YLD+ +  ++C DCF  ++KSQLSGALV++H   T+P+ N + +NLQPGTLTE  LK   N +K PPYGRCS  +   +K++N  Y YSEHAC+L TIQ +IN  C CNAIEYPI N +L FCS LP FI  K C   ++     +  C  ++  V   + CK+N++ +Y+ D+V  C+LPC  YSY SDRSTS+WPTK++Q+  I S  AR LR K + K Y+        G   ++  +L + NILE+NLL +MINRPN  VH+VEEKEVLSLTS+LSQ GGL SI+IGL++IS+VE +E+L++C    K  R++
Sbjct:  261 HALYINCHSLTIYPELRNHIKSVIMYIYLDEILKTNLCADCFMQELKSQLSGALVVVHTSDTYPDINQEAVNLQPGTLTEFNLKFILNKNKAPPYGRCSKYTETHIKLHNHNYIYSEHACQLTTIQREINDICRCNAIEYPIFNLSLPFCSALPSFISHKDCISSKTKKVLNNKTCDMEILKVFNNLGCKNNITIKYRSDVVAKCTLPCSFYSYASDRSTSTWPTKSFQLNLINSEKARELRNKEDFKPYLKLINISNEGHETEALEMLEKLNILERNLLGIMINRPNNKVHVVEEKEVLSLTSYLSQTGGLFSIFIGLSIISVVEFLELLIHCVEAFKVTRRK 604          
The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ASIC55.753e-922.58acid sensing ion channel subunit family member 5 [... [more]
SCNN1A1.305e-822.99sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A1.326e-822.99sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A1.955e-822.99sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A1.489e-722.89sodium channel epithelial 1 alpha subunit [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
asic-17.020e-822.19Degenerin-like protein asic-1 [Source:UniProtKB/S... [more]
del-41.593e-719.22DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P9183... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
scnn1b4.152e-923.59sodium channel, non voltage gated 1 beta subunit [... [more]
scnn1b1.918e-821.13sodium channel, non voltage gated 1 beta subunit [... [more]
cdh126.167e-620.18cadherin 12, type 2 (N-cadherin 2) [Source:Xenbase... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Asic51.155e-820.35acid-sensing (proton-gated) ion channel family mem... [more]
Asic51.374e-820.35acid-sensing (proton-gated) ion channel family mem... [more]
Scnn1a7.834e-720.59sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a8.560e-720.59sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a9.130e-721.96sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q25011|FANA_CORAP5.877e-1120.55FMRFamide-activated amiloride-sensitive sodium cha... [more]
sp|P55270|SCNNA_BOVIN1.936e-822.06Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|Q9NY37|ASIC5_HUMAN2.763e-822.58Acid-sensing ion channel 5 OS=Homo sapiens OX=9606... [more]
sp|P37088|SCNNA_HUMAN6.269e-822.99Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|H2Q5A1|SCNNA_PANTR6.653e-822.99Amiloride-sensitive sodium channel subunit alpha O... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2L7073.200e-10647.15Uncharacterized protein OS=Opisthorchis felineus O... [more]
G7Y6094.427e-10647.25FMRFamide-activated amiloride-sensitive sodium cha... [more]
A0A158QSX41.243e-10545.57Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A4V3SD101.636e-10447.15Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A564Y5L52.251e-10145.45Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
SCNN1A6.540e-619.12sodium channel epithelial 1 alpha subunit [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000044381.10.000e+0100.00SMESG000044381.1[more]
SMESG000028687.14.487e-13857.50SMESG000028687.1[more]
SMESG000069611.12.290e-11754.79SMESG000069611.1[more]
SMESG000064187.11.809e-10549.11SMESG000064187.1[more]
SMESG000078360.12.163e-10348.55SMESG000078360.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30006253 ID=SMED30006253|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1378bp
AAGATAGAGAGTAATTATTCATGCCCAATATATCAACTGTTATTCCTACA
ATTTATATGAAAATTACAGCCGAAATACAAATACAATGGAATTATACTTT
TATCTCGATCAAGGAATCCCGGACAGTATGTGTTTGGACTGCTTTTCCAG
TGATGTCAAATCTCAGTTGTCCGGGGCGCTGGTTTTGATTCATCGACGCT
TAACTTTTCCCAATTTTAATCATGACATCATAAATTTGCAGCCGGGCACT
CTCACAGAAATTAAGCTTAAGATATTTAATAATGTTCATAAAGAACCTCC
GTATGGCCGATGTTCTTATAAATCCCCAAAGACCATGAAAATATACAATG
ATCTGTACTCGTATTCTGAACATGCATGCAAATTACTGACAATTCAACAC
GATATAAACAAACAATGTGGATGCAATGCCATTGAATATCCTATAGATAA
TTTCAATTTATCCTTTTGCAGCAACCTGCCGAGATTTATAGAGGGTAAAC
TTTGTCACGATGACCAATCTGACATGAAGTGTAAACATCAACTTGATGCG
GTGGTAAAGAAGATCATTTGCAAGTCCAATGTATCGAGTCAGTATCAAAA
GGATATTGTCAAATCCTGCAGTCTACCCTGTGATATTTATTCATATGAAA
GTGATCGTTCAACTAGCAGTTGGCCAACAAAAACTTGGCAAATGCCATGG
ATTAAAAGCAATGCCGCAAGAAGACTTCGAAAGAAGCCGGAATTAAAAGG
ATATATTGATGCTTACAGAGAATATTTAAATGGAAGTGTGAACAAATCCT
TTAGGATTCTCAATCAGCAAAATATTCTCGAACAAAACCTCTTGGCCGTT
ATGATCAACCGACCGAATTACAATGTTCATTTGGTAGAAGAAAAAGAGGT
TCTCTCTCTAACTAGCTTTCTAAGTCAAGCGGGAGGACTTTGCAGTATTT
GGATAGGATTAACAATGATAAGCATCGTAGAGGTCATCGAGATGTTGCTA
AATTGTTTTTCTCAATTAAAAACTGCAAGAAAAAGAAAACACTTTTCGGC
TAGAGAGCTTCAAATTCAAAACATTAATCAAAACAATTATTGGCTGGGAC
CTGACACTGAATTTCAATTCATTTCGTCCGTCACCCCAATTCACAAGGCC
AATTTCATCCTTCAGGAGGAAGATCACAAAGAATCAGACCTGTCACTTTA
TGATTCCAATAGCAAACACGATATAATTTGACATTTGACAGCTTTCTAAT
ATCTCTCTGTGATTGATGAGTTTATTTTTTACTAACTGACATAAATGTAA
TTCAATTTGTTGTTTTAATTGGCAATTTATTATTTTGTTTTAAATATTAA
TTCGAATTTTTTATTTATTTTATTGTAC
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protein sequence of SMED30006253-orf-1

>SMED30006253-orf-1 ID=SMED30006253-orf-1|Name=SMED30006253-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=382bp
MELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIIN
LQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKL
LTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHDDQSDMKCK
HQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKT
WQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRILNQQNILEQ
NLLAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEV
IEMLLNCFSQLKTARKRKHFSARELQIQNINQNNYWLGPDTEFQFISSVT
PIHKANFILQEEDHKESDLSLYDSNSKHDII*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000240body wall musculature
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 5..328
e-value: 5.3E-39
score: 134.4
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 8..342
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 6..297
e-value: 1.3E-30
score: 108.6
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 94..208
e-value: 1.3E-30
score: 108.6
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 298..327
e-value: 1.3E-30
score: 108.6
NoneNo IPR availableGENE3DG3DSA:1.10.3590.10coord: 36..56
e-value: 1.3E-30
score: 108.6
NoneNo IPR availableTMHMMTMhelixcoord: 313..335