Cyclin dependent kinase like 1

Overview


Name	Cyclin dependent kinase like 1
Smed ID	SMED30006225
Length (bp)	1501

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cyclin dependent kinase like 1 (SMED30006225) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin dependent kinase like 1 (SMED30006225) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin dependent kinase like 1 (SMED30006225) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cyclin dependent kinase like 1 (SMED30006225) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30006225

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30006225	h1SMcG0018203	SmedASXL_009288	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30006225	h1SMcG0018203	dd_Smed_v4_13082_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30006225	h1SMcG0018203	dd_Smed_v4_13082_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30006225	h1SMcG0018203	dd_Smed_v4_13082_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30006225	h1SMcG0018203	dd_Smed_v4_13082_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30006225	h1SMcG0018203	dd_Smed_v6_13082_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
photoreceptor neuron	SMED30006225	h1SMcG0018203	SMED30006225	smed_20140614	PMID:22884275 Lapan et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Match: CDKL1 (cyclin dependent kinase like 1 [Source:HGNC Symbol;Acc:HGNC:1781])

HSP 1 Score: 353.984 bits (907), Expect = 1.281e-118
Identity = 175/335 (52.24%), Postives = 236/335 (70.45%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP-RWHCEANRKQILFTDQNKKVAKLPSL 1257
            M +KYE++ K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+     + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G ++P+P +++PLE  F      IS   + +L GC  MDP +R+TC+ LL   YF N+   E + +  N P R     +RK   FT+ + K+  LP L
Sbjct:    1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPN----ISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETS-KLQYLPQL 330

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Match: CDKL4 (cyclin dependent kinase like 4 [Source:HGNC Symbol;Acc:HGNC:19287])

HSP 1 Score: 342.428 bits (877), Expect = 1.077e-113
Identity = 172/377 (45.62%), Postives = 238/377 (63.13%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFT 1395
            +KYE+L K GEG+YG VFKCR K +G++VA+K+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  +    +KS+L+Q +Q + +CH  N IHRDIKPENIL+T+   +KICDFGFA+ L   + YTDYVATRWYR+PELLVGD  YG  VD+WAIGCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  F+ N +F G  +PEP +++ LEE F   + +     +  + GC +M+P  R+TC  LL+ SYF +   ++   +  N  R     NR++     Q    +  P L       Q+  +   T+ N            ++LP  P++Q    T
Sbjct:    2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPV----ALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGR-----NRRR----QQQAPKSAFPRLFLKTKICQVQRNETQTSGN------------QILPNGPILQNSMVT 353

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Match: CDKL4 (cyclin dependent kinase like 4 [Source:HGNC Symbol;Acc:HGNC:19287])

HSP 1 Score: 339.347 bits (869), Expect = 1.821e-113
Identity = 162/317 (51.10%), Postives = 220/317 (69.40%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQIL 1215
            +KYE+L K GEG+YG VFKCR K +G++VA+K+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  +    +KS+L+Q +Q + +CH  N IHRDIKPENIL+T+   +KICDFGFA+ L   + YTDYVATRWYR+PELLVGD  YG  VD+WAIGCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  F+ N +F G  +PEP +++ LEE F   + +     +  + GC +M+P  R+TC  LL+ SYF +   ++   +  N  R      R+Q+L
Sbjct:    2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPV----ALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGR---NRRRQQVL 311

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Match: CDKL1 (cyclin dependent kinase like 1 [Source:HGNC Symbol;Acc:HGNC:1781])

HSP 1 Score: 318.931 bits (816), Expect = 4.224e-106
Identity = 148/259 (57.14%), Postives = 198/259 (76.45%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNY 1032
            M +KYE++ K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+     + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G ++P+P +++PLE  F   +Y
Sbjct:    1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISY 259

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Match: CDKL2 (cyclin dependent kinase like 2 [Source:HGNC Symbol;Acc:HGNC:1782])

HSP 1 Score: 293.123 bits (749), Expect = 5.408e-93
Identity = 150/330 (45.45%), Postives = 215/330 (65.15%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGT-DNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFT--DQNKKVAK 1245
            +KYE L  +GEG+YG V KCR KDTG +VAIK+F E D    +  +A+REI++L+ LRH NLV+L+E+ K+K   +LVF+++DHT+L +LE  P  L+   ++  L+QI+ GI +CH  NIIHRDIKPENIL++++  VK+CDFGFAR L     +YTDYVATRWYR+PELLVGD+ YG  VDVWAIGC+  EM    PL+PG SD+DQL+ I+  LG+L   H++ F +N  F G ++PE    +PLE  + + + ++    I +   C  +DP KR  C  LL   +F  ++G     R+S   +   + + + +  +   QN+K  K
Sbjct:    2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVV----IDLAKKCLHIDPDKRPFCAELLHHDFF-QMDGFAE--RFSQELQLKVQKDARNVSLSKKSQNRKKEK 324

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 326.25 bits (835), Expect = 3.251e-108
Identity = 152/291 (52.23%), Postives = 202/291 (69.42%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCN 1137
            DKY+RL KLGEG+YG V+KC+ +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV LIE+FKR   +HLVF+  D T+L ELE  P+ +N   +K I+YQ+++ +++CH    IHRD+KPENI LT N QVK+ DFGFAR + T  +YTDYVATRWYRSPELLVGD+ YGPPVD+WA+GCV+AE++    LWPG+SD+DQL+ I  TLG     H   FR N++F G  +PEP +L+PL           S  ++  L  CFEM P +R +C  L+    F N
Sbjct:    2 DKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNA----SSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSN 288

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 327.02 bits (837), Expect = 4.804e-108
Identity = 152/291 (52.23%), Postives = 202/291 (69.42%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCN 1137
            DKY+RL KLGEG+YG V+KC+ +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV LIE+FKR   +HLVF+  D T+L ELE  P+ +N   +K I+YQ+++ +++CH    IHRD+KPENI LT N QVK+ DFGFAR + T  +YTDYVATRWYRSPELLVGD+ YGPPVD+WA+GCV+AE++    LWPG+SD+DQL+ I  TLG     H   FR N++F G  +PEP +L+PL           S  ++  L  CFEM P +R +C  L+    F N
Sbjct:   32 DKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNA----SSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSN 318

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 330.102 bits (845), Expect = 6.508e-108
Identity = 152/291 (52.23%), Postives = 202/291 (69.42%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCN 1137
            DKY+RL KLGEG+YG V+KC+ +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV LIE+FKR   +HLVF+  D T+L ELE  P+ +N   +K I+YQ+++ +++CH    IHRD+KPENI LT N QVK+ DFGFAR + T  +YTDYVATRWYRSPELLVGD+ YGPPVD+WA+GCV+AE++    LWPG+SD+DQL+ I  TLG     H   FR N++F G  +PEP +L+PL           S  ++  L  CFEM P +R +C  L+    F N
Sbjct:  133 DKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNA----SSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSN 419

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Match: dyf-5 (Serine/threonine-protein kinase dyf-5 [Source:UniProtKB/Swiss-Prot;Acc:B3WFY8])

HSP 1 Score: 206.068 bits (523), Expect = 3.116e-60
Identity = 105/298 (35.23%), Postives = 176/298 (59.06%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLK-------PLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            + D+Y    +LG+G +G V   +  DTG+ VAIKR  +    +    M++RE++ L+ L HPN++ L E+ +    ++ VF+++   L + ++ +     +S +++I+YQ++QG+ + H++   HRD+KPENI+      VKI DFG AR + +   YTDYV+TRWYR+PE+L+    Y  P+D+WA+GC+ AE+  + PL+PG S++DQLF II+ LG        T  ++++ EG+Q+    N +       P+E    Q    ISKE +K++      +P+KR   +  L+  YF
Sbjct:    7 LADRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKK-KFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILG--------TPNKDEWPEGYQLASAMNFRFQQVVATPME----QVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYF 291

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Match: dyf-5 (Serine/threonine-protein kinase dyf-5 [Source:UniProtKB/Swiss-Prot;Acc:B3WFY8])

HSP 1 Score: 205.297 bits (521), Expect = 4.403e-60
Identity = 105/298 (35.23%), Postives = 176/298 (59.06%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLK-------PLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            + D+Y    +LG+G +G V   +  DTG+ VAIKR  +    +    M++RE++ L+ L HPN++ L E+ +    ++ VF+++   L + ++ +     +S +++I+YQ++QG+ + H++   HRD+KPENI+      VKI DFG AR + +   YTDYV+TRWYR+PE+L+    Y  P+D+WA+GC+ AE+  + PL+PG S++DQLF II+ LG        T  ++++ EG+Q+    N +       P+E    Q    ISKE +K++      +P+KR   +  L+  YF
Sbjct:    7 LADRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKK-KFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILG--------TPNKDEWPEGYQLASAMNFRFQQVVATPME----QVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYF 291

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343387)

HSP 1 Score: 335.109 bits (858), Expect = 2.554e-110
Identity = 168/341 (49.27%), Postives = 227/341 (66.57%), Query Frame = 1

Query:  169 QMNTLNSFVRSKQICELPRSLD-RKFNTQKSMR-DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENF---IQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNN 1176
            Q + L   ++  Q+C  P  ++ R++  Q S + D+YE+L +LGEG+YG V+KCR ++TG LVA+KRF E +   +I  +A+REIR+L+ L+HPNLV L+E+F+RK  +HLVF++ + T+L ELE  P    +   K I YQ + G+ YCH+   +HRDIKPENILLT   QVK+CDFGFAR L     YTDYVATRWYR+PELLVGD  YG PVDVWAIGC+FAE++R   LWPG+SD+DQL+LI  TLG L   H   F +N+YF+G  +P P  L+PLE+      QQN +     I  L  C + DP KR +C+ L K SYF +    +  L + N+
Sbjct:   14 QNSFLYRLIQKIQVCNEPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLT----IDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNS 350

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343388)

HSP 1 Score: 330.102 bits (845), Expect = 9.459e-109
Identity = 161/310 (51.94%), Postives = 211/310 (68.06%), Query Frame = 1

Query:  256 SMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENF---IQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNN 1176
            S  D+YE+L +LGEG+YG V+KCR ++TG LVA+KRF E +   +I  +A+REIR+L+ L+HPNLV L+E+F+RK  +HLVF++ + T+L ELE  P    +   K I YQ + G+ YCH+   +HRDIKPENILLT   QVK+CDFGFAR L     YTDYVATRWYR+PELLVGD  YG PVDVWAIGC+FAE++R   LWPG+SD+DQL+LI  TLG L   H   F +N+YF+G  +P P  L+PLE+      QQN +     I  L  C + DP KR +C+ L K SYF +    +  L + N+
Sbjct:   19 SKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLT----IDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNS 324

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0302950)

HSP 1 Score: 329.331 bits (843), Expect = 3.378e-108
Identity = 161/310 (51.94%), Postives = 211/310 (68.06%), Query Frame = 1

Query:  256 SMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENF---IQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNN 1176
            S  D+YE+L +LGEG+YG V+KCR ++TG LVA+KRF E +   +I  +A+REIR+L+ L+HPNLV L+E+F+RK  +HLVF++ + T+L ELE  P    +   K I YQ + G+ YCH+   +HRDIKPENILLT   QVK+CDFGFAR L     YTDYVATRWYR+PELLVGD  YG PVDVWAIGC+FAE++R   LWPG+SD+DQL+LI  TLG L   H   F +N+YF+G  +P P  L+PLE+      QQN +     I  L  C + DP KR +C+ L K SYF +    +  L + N+
Sbjct:   42 SKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLT----IDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNS 347

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343389)

HSP 1 Score: 328.561 bits (841), Expect = 3.864e-108
Identity = 161/310 (51.94%), Postives = 211/310 (68.06%), Query Frame = 1

Query:  256 SMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENF---IQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNN 1176
            S  D+YE+L +LGEG+YG V+KCR ++TG LVA+KRF E +   +I  +A+REIR+L+ L+HPNLV L+E+F+RK  +HLVF++ + T+L ELE  P    +   K I YQ + G+ YCH+   +HRDIKPENILLT   QVK+CDFGFAR L     YTDYVATRWYR+PELLVGD  YG PVDVWAIGC+FAE++R   LWPG+SD+DQL+LI  TLG L   H   F +N+YF+G  +P P  L+PLE+      QQN +     I  L  C + DP KR +C+ L K SYF +    +  L + N+
Sbjct:   28 SKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLT----IDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNS 333

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Match: Cdk7 (gene:FBgn0263237 transcript:FBtr0070756)

HSP 1 Score: 200.675 bits (509), Expect = 1.311e-59
Identity = 108/296 (36.49%), Postives = 171/296 (57.77%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRF---SEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDN-IYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRR-NKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCN 1137
            ++Y +L  LGEG + TV+K R   T ++VA+K+    S  D    I+  A+REI++L+ L+H N++ L+++F +  ++ LVF ++D  L   ++     L ++N+K+     ++G+EY H + I+HRD+KP N+L+  +  +KI DFG A+  G+ N IYT +V TRWYRSPELL G   YG  VD+WA+GC+ AE++   P  PG SDLDQL  I +TLG+  +       + + Y +    P      PL+  F         + I ++   F M+P +R++C   L   YF N
Sbjct:   10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPG----TPLDNIFTAA----GNDLIHLMQRLFAMNPLRRVSCREALSMPYFAN 297

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Zebrafish
Match: cdkl1 (cyclin-dependent kinase-like 1 (CDC2-related kinase) [Source:NCBI gene;Acc:445316])

HSP 1 Score: 349.362 bits (895), Expect = 4.576e-117
Identity = 164/302 (54.30%), Postives = 225/302 (74.50%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL-NGSESVLR 1164
            +KYE++ K+GEG+YG VFKCR KDTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI++Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWA+GCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N++F G  VPEP  ++PLE  +   +Y    + + ++ GC  MDP +R++C+ LL++ YF +L   SESV R
Sbjct:    2 EKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSY----QALSLMKGCLRMDPAERLSCEQLLEQPYFDSLREESESVTR 299

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Zebrafish
Match: cdkl5 (cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZDB-GENE-081022-110])

HSP 1 Score: 244.588 bits (623), Expect = 8.972e-71
Identity = 124/307 (40.39%), Postives = 188/307 (61.24%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP 1179
            +K+E L  +GEGAYG V KCR K+T ELVAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P       ++S ++Q+++ I +CH++ I+HRDIKPEN+L++ N  +K+CDFGFAR L  G+D  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + L+  ++    II+   + ++     ++P +R   +  L    F  L G E     S  P
Sbjct:   11 NKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLG---IINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTP 313

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Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP 1179
            +K+E L  +GEGAYG V KCR K+T ELVAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P       ++S ++Q+++ I +CH++ I+HRDIKPEN+L++ N  +K+CDFGFAR L  G+D  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + L+  ++    II+   + ++     ++P +R   +  L    F  L G E     S  P
Sbjct:   11 NKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLG---IINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTP 313

[Close]

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP 1179
            +K+E L  +GEGAYG V KCR K+T ELVAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P       ++S ++Q+++ I +CH++ I+HRDIKPEN+L++ N  +K+CDFGFAR L  G+D  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + L+  ++    II+   + ++     ++P +R   +  L    F  L G E     S  P
Sbjct:   11 NKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLG---IINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTP 313

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Zebrafish
Match: cdkl5 (cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZDB-GENE-081022-110])

HSP 1 Score: 244.202 bits (622), Expect = 1.485e-70
Identity = 124/307 (40.39%), Postives = 188/307 (61.24%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP 1179
            +K+E L  +GEGAYG V KCR K+T ELVAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P       ++S ++Q+++ I +CH++ I+HRDIKPEN+L++ N  +K+CDFGFAR L  G+D  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + L+  ++    II+   + ++     ++P +R   +  L    F  L G E     S  P
Sbjct:   11 NKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLG---IINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTP 313

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Match: CDKL1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:100496578])

HSP 1 Score: 340.117 bits (871), Expect = 3.291e-113
Identity = 157/290 (54.14%), Postives = 212/290 (73.10%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE++ K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ + IHRD+KPENIL+T +  +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  + G L   H+  F  N++F G  +P+P N++PLE  F      IS + + ++ GC  MDP KR+ C  LL   YF
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRKLHLVFEYCDHTVLHELDKYPRGVPEHLVKSITWQTLQAVNFCHKHHCIHRDVKPENILITRHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGIPLWPGKSDVDQLYLIRKSQGDLIARHQQVFSTNQFFSGVSIPDPENMEPLELRFPN----ISSQALGLMKGCLHMDPAKRLACQQLLDHPYF 287

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Match: CDKL1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:100496578])

HSP 1 Score: 323.168 bits (827), Expect = 1.467e-106
Identity = 151/291 (51.89%), Postives = 207/291 (71.13%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKIL-HGCFEMDPKKRITCDALLKESYF 1131
            +KYE++ K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ + IHRD+KPENIL+T +  +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  + G L   H+  F  N++F G  +P+P N+    +       +++   + +   GC  MDP KR+ C  LL   YF
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRKLHLVFEYCDHTVLHELDKYPRGVPEHLVKSITWQTLQAVNFCHKHHCIHRDVKPENILITRHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGIPLWPGKSDVDQLYLIRKSQGDLIARHQQVFSTNQFFSGVSIPDPENMLISIKKHPGLGILVTGFHLSLQSQGCLHMDPAKRLACQQLLDHPYF 292

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Match: vsx2 (visual system homeobox 2 [Source:Xenbase;Acc:XB-GENE-853775])

HSP 1 Score: 284.263 bits (726), Expect = 7.063e-89
Identity = 145/307 (47.23%), Postives = 201/307 (65.47%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPR 1182
            +KYE L  +GEG+YG V KCR K+ G +VA+K+F E +    +  +A+REI++L+ LRH NLV+L+E+ K+K   +LVF+++D T+L +LE  P  L+ S ++  L+QI++GI +CH  NIIHRDIKPENIL++ +  VK+CDFGFAR L G    YTDYVATRWYR+PELLVGDI YG  VDVWAIGC+  EM+   PL+PG SD+DQL  I+   G+L   H++ F RN  F GF +P+    + LE  + + + I+    + +   C  +DP KR  C  LL    F   + SE   R+S   R
Sbjct:    2 EKYENLGLVGEGSYGMVMKCRNKENGRIVAVKKFLESEDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDRTVLDDLEQFPNGLDFSKVRKYLFQIIRGIGFCHSHNIIHRDIKPENILVSHSGIVKLCDFGFARTLAGPGEDYTDYVATRWYRAPELLVGDIKYGKAVDVWAIGCIVTEMLTAQPLFPGDSDIDQLHHIVKCQGNLTPRHQELFYRNPMFAGFSLPDMKEAESLEWRYPKLSPIM----LDLAKSCLHIDPDKRPACMTLLLHELFTKDSFSE---RFSQEIR 301

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Match: vldlr (very low density lipoprotein receptor [Source:Xenbase;Acc:XB-GENE-971958])

HSP 1 Score: 244.973 bits (624), Expect = 8.301e-71
Identity = 126/318 (39.62%), Postives = 192/318 (60.38%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL----NGSESVLRYSNNPRWHCEAN 1200
            +K+E L  +GEGAYG V KCR K+T E+VAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P  +    + + +YQ+++ I +CH+++I+HRDIKPEN+L++ N  +K+CDFGFAR L  G++  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + LE  ++    IIS   + ++    +++P  R   +  L    F        G  S  R S     H E+N
Sbjct:   11 NKFEVLGVVGEGAYGVVLKCRHKETKEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVTNYIYQLIKAIHWCHKNDIVHRDIKPENLLISYNDVLKLCDFGFARNLSEGSNANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGMRFPAVNHPQSLERRYLG---IISSVLLDLMKNLLKLNPSDRFLTEQSLNHPAFQTQRLLDRGGTSPSRSSKRKTHHSESN 324

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Match: vldlr (very low density lipoprotein receptor [Source:Xenbase;Acc:XB-GENE-971958])

HSP 1 Score: 224.172 bits (570), Expect = 5.267e-64
Identity = 120/318 (37.74%), Postives = 182/318 (57.23%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL----NGSESVLRYSNNPRWHCEAN 1200
            +K+E L  +GEGAYG V KCR K    +   +    P          +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P  +    + + +YQ+++ I +CH+++I+HRDIKPEN+L++ N  +K+CDFGFAR L  G++  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + LE  ++    IIS   + ++    +++P  R   +  L    F        G  S  R S     H E+N
Sbjct:   11 NKFEVLGVVGEGAYGVVLKCRHKVRAIIFITEFICPPFLFREFKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVTNYIYQLIKAIHWCHKNDIVHRDIKPENLLISYNDVLKLCDFGFARNLSEGSNANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGMRFPAVNHPQSLERRYLG---IISSVLLDLMKNLLKLNPSDRFLTEQSLNHPAFQTQRLLDRGGTSPSRSSKRKTHHSESN 324

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Mouse
Match: Cdkl4 (cyclin-dependent kinase-like 4 [Source:MGI Symbol;Acc:MGI:3587025])

HSP 1 Score: 347.051 bits (889), Expect = 2.872e-116
Identity = 158/289 (54.67%), Postives = 212/289 (73.36%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE+L K+GEG+YG VFKCR K +G++VAIK+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  ++   +KS+L+Q +Q + +CH+ N IHRD+KPENIL+T+   +KICDFGFAR L   + YTDYVATRWYR+PELLVGD  YG  VDVWA+GCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  FR N++F G  +PEP +++ LEE F      +    +  + GC +M+P +R+TC  LL  +YF
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSN----VQPVALSFMKGCLKMNPDERLTCAQLLDSAYF 286

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Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE+L K+GEG+YG VFKCR K +G++VAIK+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  ++   +KS+L+Q +Q + +CH+ N IHRD+KPENIL+T+   +KICDFGFAR L   + YTDYVATRWYR+PELLVGD  YG  VDVWA+GCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  FR N++F G  +PEP +++ LEE F      +    +  + GC +M+P +R+TC  LL  +YF
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSN----VQPVALSFMKGCLKMNPDERLTCAQLLDSAYF 286

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Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE+L K+GEG+YG VFKCR K +G++VAIK+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  ++   +KS+L+Q +Q + +CH+ N IHRD+KPENIL+T+   +KICDFGFAR L   + YTDYVATRWYR+PELLVGD  YG  VDVWA+GCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  FR N++F G  +PEP +++ LEE F      +    +  + GC +M+P +R+TC  LL  +YF
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSN----VQPVALSFMKGCLKMNPDERLTCAQLLDSAYF 286

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Mouse
Match: Cdkl1 (cyclin-dependent kinase-like 1 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1918341])

HSP 1 Score: 343.199 bits (879), Expect = 1.261e-114
Identity = 177/356 (49.72%), Postives = 238/356 (66.85%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYN 1329
            +KYE++ K+GEG+YG VFKCR +DTG++VAIKRF E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+     + +  +K+I +Q +Q + +CH+ N IHRD+KPENIL+T+   +K+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G ++P+P +++ LE  F      IS   +  L GC  MDP +R+TC+ LL+  YF      +S+       R H +  RK +    Q++K   L  L Y P   QLT   I    +N  Y+
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPN----ISYSALGFLKGCLHMDPAERLTCEQLLQHPYF------DSIREVGELTRQHDKPARKTL---RQSRK--HLTGLQYLP---QLTSSRILPALDNKKYH 339

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Mouse
Match: Cdkl2 (cyclin-dependent kinase-like 2 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1858227])

HSP 1 Score: 286.189 bits (731), Expect = 1.033e-89
Identity = 140/292 (47.95%), Postives = 199/292 (68.15%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGT-DNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPE--PCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE L  +GEG+YG V KCR KD+G +VAIK+F E D    +  +A+REI++L+ LRH NLV+L+E+ K+K   +LVF+++DHT+L +L+  P  L+   ++  L+QI+ GI +CH  NIIHRDIKPENIL++++  VK+CDFGFAR L     +YTDYVATRWYR+PELLVGD+ YG  VD+WAIGC+  EM+   PL+PG+SD+DQL  I+  LG+L   H++ F +N  F G ++PE      +PLE  + +    + +  I +   C  +DP KR  C  LL+  +F
Sbjct:    2 EKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPK----LPEAVISLAKKCLHIDPDKRPFCADLLRHDFF 289

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BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Match: sp|Q00532|CDKL1_HUMAN (Cyclin-dependent kinase-like 1 OS=Homo sapiens OX=9606 GN=CDKL1 PE=1 SV=6)

HSP 1 Score: 354.369 bits (908), Expect = 5.229e-118
Identity = 175/335 (52.24%), Postives = 236/335 (70.45%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNP-RWHCEANRKQILFTDQNKKVAKLPSL 1257
            M +KYE++ K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+     + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G ++P+P +++PLE  F      IS   + +L GC  MDP +R+TC+ LL   YF N+   E + +  N P R     +RK   FT+ + K+  LP L
Sbjct:    1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPN----ISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETS-KLQYLPQL 330

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BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Match: sp|Q3TZA2|CDKL4_MOUSE (Cyclin-dependent kinase-like 4 OS=Mus musculus OX=10090 GN=Cdkl4 PE=2 SV=1)

HSP 1 Score: 347.051 bits (889), Expect = 2.009e-115
Identity = 158/289 (54.67%), Postives = 212/289 (73.36%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE+L K+GEG+YG VFKCR K +G++VAIK+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  ++   +KS+L+Q +Q + +CH+ N IHRD+KPENIL+T+   +KICDFGFAR L   + YTDYVATRWYR+PELLVGD  YG  VDVWA+GCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  FR N++F G  +PEP +++ LEE F      +    +  + GC +M+P +R+TC  LL  +YF
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSN----VQPVALSFMKGCLKMNPDERLTCAQLLDSAYF 286

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BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Match: sp|Q6AXJ9|CDKL1_DANRE (Cyclin-dependent kinase-like 1 OS=Danio rerio OX=7955 GN=cdkl1 PE=2 SV=1)

HSP 1 Score: 345.895 bits (886), Expect = 7.197e-115
Identity = 163/302 (53.97%), Postives = 224/302 (74.17%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL-NGSESVLR 1164
            +KYE++ K+GEG+YG VFKCR KDTG++VAIK+F E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI++Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTD VATRWYR+PELLVGD  YGPPVDVWA+GCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N++F G  VPEP  ++PLE  +   +Y    + + ++ GC  MDP +R++C+ LL++ YF +L   SESV R
Sbjct:    2 EKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSY----QALSLMKGCLRMDPAERLSCEQLLEQPYFDSLREESESVTR 299

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BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Match: sp|Q8CEQ0|CDKL1_MOUSE (Cyclin-dependent kinase-like 1 OS=Mus musculus OX=10090 GN=Cdkl1 PE=2 SV=1)

HSP 1 Score: 343.199 bits (879), Expect = 8.821e-114
Identity = 177/356 (49.72%), Postives = 238/356 (66.85%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYN 1329
            +KYE++ K+GEG+YG VFKCR +DTG++VAIKRF E +    I  +A+REIRML+ L+HPNLV+L+E+F+RK  +HLVF+Y DHT+L EL+     + +  +K+I +Q +Q + +CH+ N IHRD+KPENIL+T+   +K+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G ++P+P +++ LE  F      IS   +  L GC  MDP +R+TC+ LL+  YF      +S+       R H +  RK +    Q++K   L  L Y P   QLT   I    +N  Y+
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPN----ISYSALGFLKGCLHMDPAERLTCEQLLQHPYF------DSIREVGELTRQHDKPARKTL---RQSRK--HLTGLQYLP---QLTSSRILPALDNKKYH 339

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BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Match: sp|Q5MAI5|CDKL4_HUMAN (Cyclin-dependent kinase-like 4 OS=Homo sapiens OX=9606 GN=CDKL4 PE=2 SV=2)

HSP 1 Score: 342.428 bits (877), Expect = 5.170e-113
Identity = 172/377 (45.62%), Postives = 238/377 (63.13%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFT 1395
            +KYE+L K GEG+YG VFKCR K +G++VA+K+F E +    +  +A+REIRML+ L+HPNLV+LIE+F+RK  +HLVF+Y DHTLL ELE  P  +    +KS+L+Q +Q + +CH  N IHRDIKPENIL+T+   +KICDFGFA+ L   + YTDYVATRWYR+PELLVGD  YG  VD+WAIGCVFAE++   PLWPGKSD+DQL+LII TLG L   H+  F+ N +F G  +PEP +++ LEE F   + +     +  + GC +M+P  R+TC  LL+ SYF +   ++   +  N  R     NR++     Q    +  P L       Q+  +   T+ N            ++LP  P++Q    T
Sbjct:    2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPV----ALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGR-----NRRR----QQQAPKSAFPRLFLKTKICQVQRNETQTSGN------------QILPNGPILQNSMVT 353

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BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Match: A0A267DKM9 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000280g4 PE=3 SV=1)

HSP 1 Score: 382.489 bits (981), Expect = 1.333e-126
Identity = 191/357 (53.50%), Postives = 251/357 (70.31%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNK 1332
            DKYE+L K+GEGAYG VFKCR + TGELVAIK+F+E +    IH +A+REIRML+ L+H NLV+L+E+FKRK  +HLVFQYIDHTLL E+EAKPY +++  ++ I YQ++  I +CH  N IHRD+KPENIL+T + +VK+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAEM++  PLWPG+SDLDQL+LII TLG L   HK+ F+ N +F G ++PEP N + LEE F      +S +E++ L  CF+MDP +R TC+ L +  YF + +    V R  +       A R+++   D  K+ A+ PSL      N +T+ I  +  NN+   K
Sbjct:    2 DKYEKLGKIGEGAYGVVFKCRQRFTGELVAIKKFTESEEDPLIHKIAMREIRMLKQLKHDNLVNLLEVFKRKKRLHLVFQYIDHTLLNEMEAKPYGMDRGQIRKITYQLLDAISFCHSHNCIHRDVKPENILVTRDTKVKLCDFGFARLLTGPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAEMLKGIPLWPGRSDLDQLYLIIKTLGELLPRHKEIFQENSFFRGLKIPEPENQESLEEKFQHMKEPLSTKELQFLQFCFKMDPVQRATCEDLKRFDYF-DRSMYSDVYRDED-------AGRRRMKALDM-KQRAQWPSL----QQNHMTNPISKSPQNNSKQGK 345

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BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Match: A0A267E989 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000280g1 PE=3 SV=1)

HSP 1 Score: 382.489 bits (981), Expect = 1.486e-126
Identity = 191/357 (53.50%), Postives = 251/357 (70.31%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNK 1332
            DKYE+L K+GEGAYG VFKCR + TGELVAIK+F+E +    IH +A+REIRML+ L+H NLV+L+E+FKRK  +HLVFQYIDHTLL E+EAKPY +++  ++ I YQ++  I +CH  N IHRD+KPENIL+T + +VK+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAEM++  PLWPG+SDLDQL+LII TLG L   HK+ F+ N +F G ++PEP N + LEE F      +S +E++ L  CF+MDP +R TC+ L +  YF + +    V R  +       A R+++   D  K+ A+ PSL      N +T+ I  +  NN+   K
Sbjct:    2 DKYEKLGKIGEGAYGVVFKCRQRFTGELVAIKKFTESEEDPLIHKIAMREIRMLKQLKHDNLVNLLEVFKRKKRLHLVFQYIDHTLLNEMEAKPYGMDRGQIRKITYQLLDAISFCHSHNCIHRDVKPENILITRDTKVKLCDFGFARLLTGPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAEMLKGIPLWPGRSDLDQLYLIIKTLGELLPRHKEIFQENSFFRGLKIPEPENQESLEEKFQHMKEPLSTKELQFLQFCFKMDPVQRATCEDLKRFDYF-DRSMYSDVYRDED-------AGRRRMKALDM-KQRAQWPSL----QQNHMTNPISKSPQNNSKQGK 345

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BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Match: A0A267ER40 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000458g8 PE=3 SV=1)

HSP 1 Score: 373.629 bits (958), Expect = 1.409e-122
Identity = 173/305 (56.72%), Postives = 230/305 (75.41%), Query Frame = 1

Query:  241 FNTQKSMR-------DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            F+  KS+R       +KYE+L K+GEGAYG VFKCR + +GELVAIK+F+E +    IH +A+REIRML+ L+H NLV+L+E+FKRK  +HLVFQYIDHTLL E+E++P  +++S ++ I YQ++  I +CH  N IHRD+KPENIL+T + +VK+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWA+GCVFAEM++  PLWPG+SDLDQL LII +LG L   H+D F +N YF+G ++PEP     +E+ F+     ++++E++ LH CF+MDP +R TC+ L K  YF
Sbjct:   16 FSNLKSLRSRQPLLMEKYEKLGKIGEGAYGVVFKCRHRFSGELVAIKKFTESEEDPLIHKIAMREIRMLKQLKHDNLVNLLEVFKRKKRLHLVFQYIDHTLLNEIESRPSGMDRSQIRKITYQLLDAISFCHLHNCIHRDVKPENILITRDAKVKLCDFGFARLLTGPGDEYTDYVATRWYRSPELLVGDTQYGPPVDVWAVGCVFAEMLKGTPLWPGRSDLDQLHLIIKSLGDLVPRHRDIFYQNAYFQGLKIPEPEQQDQIEQKFVHMREPLTQKELQFLHFCFKMDPVQRATCEELKKTDYF 320

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BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Match: A0A1I8J290 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 372.089 bits (954), Expect = 2.665e-122
Identity = 169/290 (58.28%), Postives = 224/290 (77.24%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE+L K+GEGAYG VFKCR + +GELVAIK+F+E +    IH +A+REIRML+ L+H NLV+L+E+FKRK  +HLVFQYIDHTLL E+E++P  +++S ++ I YQ++  I +CH  N IHRD+KPENIL+T + +VK+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWA+GCVFAEM++  PLWPG+SDLDQL LII +LG L   H+D F +N YF+G ++PEP     +E+ F+     ++++E++ LH CF+MDP +R TC+ L K  YF
Sbjct:    2 EKYEKLGKIGEGAYGVVFKCRHRFSGELVAIKKFTESEEDPLIHKIAMREIRMLKQLKHDNLVNLLEVFKRKKRLHLVFQYIDHTLLNEIESRPSGMDRSQIRKITYQLLDAISFCHLHNCIHRDVKPENILITRDAKVKLCDFGFARLLTGPGDEYTDYVATRWYRSPELLVGDTQYGPPVDVWAVGCVFAEMLKGTPLWPGRSDLDQLHLIIKSLGDLVPRHRDIFYQNAYFQGLKIPEPEQQDQIEQKFVHMREPLTQKELQFLHFCFKMDPVQRATCEELKKTDYF 291

[Close]

BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Match: A0A267FJ04 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000458g7 PE=3 SV=1)

HSP 1 Score: 373.244 bits (957), Expect = 6.362e-122
Identity = 171/299 (57.19%), Postives = 228/299 (76.25%), Query Frame = 1

Query:  238 KFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            K + Q  + +KYE+L K+GEGAYG VFKCR + +GELVAIK+F+E +    IH +A+REIRML+ L+H NLV+L+E+FKRK  +HLVFQYIDHTLL E+E++P  +++S ++ I YQ++  I +CH  N IHRD+KPENIL+T + +VK+CDFGFAR L G  + YTDYVATRWYRSPELLVGD  YGPPVDVWA+GCVFAEM++  PLWPG+SDLDQL LII +LG L   H+D F +N YF+G ++PEP     +E+ F+     ++++E++ LH CF+MDP +R TC+ L K  YF
Sbjct:   56 KSSRQPLLMEKYEKLGKIGEGAYGVVFKCRHRFSGELVAIKKFTESEEDPLIHKIAMREIRMLKQLKHDNLVNLLEVFKRKKRLHLVFQYIDHTLLNEIESRPSGMDRSQIRKITYQLLDAISFCHLHNCIHRDVKPENILITRDAKVKLCDFGFARLLTGPGDEYTDYVATRWYRSPELLVGDTQYGPPVDVWAVGCVFAEMLKGTPLWPGRSDLDQLHLIIKSLGDLVPRHRDIFYQNAYFQGLKIPEPEQQDQIEQKFVHMREPLTQKELQFLHFCFKMDPVQRATCEELKKTDYF 354

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:103022052])

HSP 1 Score: 340.502 bits (872), Expect = 1.087e-113
Identity = 160/290 (55.17%), Postives = 216/290 (74.48%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE++ K+GEG+YG VFKCR KDTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+LIE+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N++F G  VPEP  ++PLE+ +      IS + + ++ GC  MDP +R++C+ LL+  YF
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHCNLVNLIEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEYLVKSITWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSNNQFFSGVCVPEPQEMEPLEQKYPN----ISYQALSLMKGCLCMDPAERLSCEQLLEHPYF 287

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Match: ENSAMXT00000057054.1 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:103024925])

HSP 1 Score: 335.495 bits (859), Expect = 8.363e-112
Identity = 155/296 (52.36%), Postives = 216/296 (72.97%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGS 1149
            +KYE+L K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF++ + T+L EL+  P  + ++ +KSI++Q +Q + +CH++N IHRD+KPENILLT+   +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGP VDVWA+GCVFAE++   PLWPG+SD+DQL+LI  TLG L   H+  FR N +F G  +PEP  ++PLE+ F    +  S   I ++  C  MDP  R++C+ LL+ +YF    G+
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHVNLVNLLEVFRRKRRLHLVFEFCEQTVLNELDKHPKGVPEAQLKSIIWQTLQAVNFCHKNNCIHRDVKPENILLTKTGIIKLCDFGFARILTGPGDDYTDYVATRWYRAPELLVGDTQYGPAVDVWALGCVFAELLNGNPLWPGRSDVDQLYLIRRTLGDLIPRHQQVFRSNVFFSGVSIPEPDTMEPLEKRF----HGASPHAIAVMKSCLVMDPAGRLSCEELLELTYFQEEGGA 293

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Match: ENSAMXT00000052448.1 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:103024925])

HSP 1 Score: 335.495 bits (859), Expect = 8.363e-112
Identity = 155/296 (52.36%), Postives = 216/296 (72.97%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGS 1149
            +KYE+L K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF++ + T+L EL+  P  + ++ +KSI++Q +Q + +CH++N IHRD+KPENILLT+   +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGP VDVWA+GCVFAE++   PLWPG+SD+DQL+LI  TLG L   H+  FR N +F G  +PEP  ++PLE+ F    +  S   I ++  C  MDP  R++C+ LL+ +YF    G+
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHVNLVNLLEVFRRKRRLHLVFEFCEQTVLNELDKHPKGVPEAQLKSIIWQTLQAVNFCHKNNCIHRDVKPENILLTKTGIIKLCDFGFARILTGPGDDYTDYVATRWYRAPELLVGDTQYGPAVDVWALGCVFAELLNGNPLWPGRSDVDQLYLIRRTLGDLIPRHQQVFRSNVFFSGVSIPEPDTMEPLEKRF----HGASPHAIAVMKSCLVMDPAGRLSCEELLELTYFQEEGGA 293

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:103022052])

HSP 1 Score: 329.717 bits (844), Expect = 1.426e-109
Identity = 156/290 (53.79%), Postives = 212/290 (73.10%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE++ K+GEG+YG VFKCR KDTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+LIE+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T++  +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N++F G  VPEP  +          + +++ ++  +L GC  MDP +R++C+ LL+  YF
Sbjct:    2 EKYEKIGKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHCNLVNLIEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEYLVKSITWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSNNQFFSGVCVPEPQEM---------VSVLVALDKSGLLRGCLCMDPAERLSCEQLLEHPYF 282

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Match: ENSAMXT00000033332.1 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:103024925])

HSP 1 Score: 317.775 bits (813), Expect = 6.369e-105
Identity = 152/296 (51.35%), Postives = 210/296 (70.95%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGS 1149
            +KYE+L K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF++ + T+L EL+  P  + ++ +KSI++Q +Q + +CH++N IHRD+KPENILLT+   +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGP VDVWA+GCVFAE++   PLWPG+SD+DQL+LI  TLG L   H+  FR N +F G  +PEP  +    E F+   Y +          C  MDP  R++C+ LL+ +YF    G+
Sbjct:    2 EKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHVNLVNLLEVFRRKRRLHLVFEFCEQTVLNELDKHPKGVPEAQLKSIIWQTLQAVNFCHKNNCIHRDVKPENILLTKTGIIKLCDFGFARILTGPGDDYTDYVATRWYRAPELLVGDTQYGPAVDVWALGCVFAELLNGNPLWPGRSDVDQLYLIRRTLGDLIPRHQQVFRSNVFFSGVSIPEPDTM----ETFM---YCVCS--------CLVMDPAGRLSCEELLELTYFQEEGGA 282

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 209.149 bits (531), Expect = 4.473e-64
Identity = 118/305 (38.69%), Postives = 170/305 (55.74%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELE-AKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGT-DNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGS-----------LPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL 1140
            D ++++ K+GEG YG V+K R K TGE VA+K+         + + AIREI +LR L HPN+V L+ I   +  ++LVF+ +D  L + ++ A P  +    +KS LYQ++QGI +CH   I+HRD+KP+N+L+     +K+ DFG AR  G     YT  V T WYR+PE+L+G  HY   VDVW+IGC+FAEM+    L+PG S++DQLF I  TLG+           LPD +K TF R    E  +V    N                 E   +L    + DP +R+T +  L   +F N+
Sbjct:    2 DNFQKVEKIGEGTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLTIIHSEKKLYLVFELLDQDLKKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAEGAIKLADFGLARAFGVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQLPD-YKSTFPRWANQELTKVVPTLNF----------------EGRDLLALMLQYDPNQRVTANMALSHCFFQNV 289

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 204.142 bits (518), Expect = 3.288e-62
Identity = 107/298 (35.91%), Postives = 176/298 (59.06%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELE-AKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGF-QVPE--PCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLN 1143
            D ++++ K+GEG YG V+K R K TG+ VA+K+         + + AIREI +LR L HPN+V L+++   +  ++LVF+++D  L + ++ A P  ++   +KS ++Q++QGI +CH    +HRD+KP+N+L+  +  +K+ DFG AR  G     YT  V T WYR+PE+L+G  +Y   VDVW++GC+FAEM+    L+PG S++DQLF I  TLG+ PD           ++G  Q+P+  P   +   ++  +   ++      +L    + DP +R++  A L   +F NL 
Sbjct:    2 DLFQKVEKIGEGTYGVVYKARHKMTGDTVALKKIRLDTETEGVPSTAIREIALLRELNHPNIVRLLDVIHSETKLYLVFEFLDQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGT-PD--------ETVWQGITQLPDYKPSFPRWCAQDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLE 290

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Match: cdk7 (cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GENE-010320-2])

HSP 1 Score: 198.749 bits (504), Expect = 2.330e-59
Identity = 114/307 (37.13%), Postives = 167/307 (54.40%), Query Frame = 1

Query:  271 YERLYKLGEGAYGTVFKCRLKDTGELVAIKRFS---EPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDN-IYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGS-----------LPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNG 1146
            Y+++  LGEG + TV+K   K T ++VAIK+       +    I+  A+REI++L+ L HPN++ L++ F  K +I LVF ++D  L   ++     L+ +N+KS +   +QG+EY H   I+HRD+KP N+LL E   +K+ DFG A+  G+ + +YT  V TRWYRSPELL G   YG  VD+WA+GC+ AE++   P  PG SDLDQL  I   LG+           LPD     +   K F G          PLE  F       + + +++L G F   P  R+T    ++  YF N  G
Sbjct:   26 YDKIDFLGEGQFATVYKAMDKVTNKIVAIKKIKLGHRTEAKDGINRTALREIKLLQELNHPNIIGLLDAFGHKSNISLVFDFMDTDLEVIVKDTSLVLSPANIKSFMVMTLQGLEYLHMHWILHRDMKPNNLLLDEQGVLKLADFGLAKSFGSPSRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRTPFLPGDSDLDQLSKIFEALGTPTEELWPGMTNLPD-----YVEYKSFPG---------TPLENIFTAA----TDDLLELLQGLFTFSPAARLTATQAMQMPYFSNRPG 314

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003004.1 (pep scaffold:Pmarinus_7.0:GL476686:67050:81358:1 gene:ENSPMAG00000002741.1 transcript:ENSPMAT00000003004.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 195.667 bits (496), Expect = 1.031e-58
Identity = 107/292 (36.64%), Postives = 169/292 (57.88%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELL--VGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE L  +GEG+YG V KCR +DTG++VAIK+F + +   S+  +A REI+ML+ LRH NLV+L+E+F+RK  ++LVF+++DHT+L ELE  P  L  + ++  L Q+++ + +C+ +N++HR   P N+ L        C F F          ++D     + +SP +   V        VDVWA+GCV  E+    P++PG SD+DQL+ I+   G+L   H++ F +N  F G +VPE   ++PLE    ++   +    + ++  C  MD   R  C  LL+  YF
Sbjct:    2 EKYENLGLVGEGSYGIVLKCRHRDTGQIVAIKKFLDSEDHKSVRKIAAREIKMLKQLRHENLVNLLEVFRRKRRLYLVFEFVDHTVLDELERYPRGLPTARVRPCLLQVLRAVGFCNSNNVVHRWTTPVNVFLRIVDPCYFCIFLFQEASQHPFKCHSDIRLNEYKQSPLMFACVCVCERYRAVDVWAVGCVAVEIQTGEPVFPGDSDIDQLYQIVKCFGNLMPRHRELFYKNPVFTGLKVPEVHAVEPLE----KRLPRLPPLLLDLIKQCLYMDADTRPPCSRLLQHDYF 289

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Match: mak (male germ cell-associated kinase [Source:ZFIN;Acc:ZDB-GENE-030131-7279])

HSP 1 Score: 198.364 bits (503), Expect = 8.483e-57
Identity = 109/299 (36.45%), Postives = 168/299 (56.19%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEG--------FQVPE--PCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            ++Y  + +LG+G YG+V   R  +TGELVAIK+       +    M +RE++ L+ L H N++ L E+ +    ++ VF+Y+   L Q ++ +     +S +++I+YQI+QG+ + H+    HRD+KPEN+L      VKI DFG AR + +   YTDYV+TRWYR PE+L+    Y  P+D+WA+GC+ AE+  + PL+PG S++DQ+F I   LG        T ++N + EG        F+ P+  P NLK L  N        S E I ++      +PKKR      L+  YF
Sbjct:    2 NRYTTIKQLGDGTYGSVLMGRSNETGELVAIKKMKR-KFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDCLYFVFEYMKENLYQLMKDRNKLFPESMIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRGPEVLLRSTSYSSPIDIWALGCIMAELYTLRPLFPGSSEVDQIFKICQVLG--------TPKKNDWPEGHQLAAAMNFRWPQCVPTNLKTLIPN-------ASNEAIHLMRDMLHWEPKKRPNAVQSLRYPYF 284

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952])

HSP 1 Score: 179.104 bits (453), Expect = 7.904e-53
Identity = 100/310 (32.26%), Postives = 174/310 (56.13%), Query Frame = 1

Query:  256 SMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAK-----PYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGS-----------LPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFC 1134
            S   ++++L KLG G Y TV+K   K TG  VA+K   + D+     + AIREI +++ L+H N+V L ++   ++ + LVF+++D+ L + ++++     P  L  + +K   +Q++QG+ +CH + I+HRD+KP+N+L+ +  Q+K+ DFG AR  G   N ++  V T WYR+P++L+G   Y   +D+W+ GC+ AEMI   PL+PG +D +QL LI + +G+           LP  + +  +R    +  QV +P   +PL+ N +             LHG  +++P  R++    L   +F 
Sbjct:    2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPR-DLRQVLQPHTKEPLDGNLMD-----------FLHGLLQLNPDMRLSAKQALHHPWFA 298

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Match: KIN28 (Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002266])

HSP 1 Score: 179.104 bits (453), Expect = 9.809e-53
Identity = 94/292 (32.19%), Postives = 159/292 (54.45%), Query Frame = 1

Query:  268 KYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNL 1140
            +Y +  K+GEG Y  V+      TG  +AIK     +    +   AIRE++ L+ ++HPN++ LI+IF    +++LV +++   L   ++ K      +++K+ +   ++G+ +CHR+ I+HRD+KP N+L + + Q+K+ DFG AR +     I T  V TRWYR+PELL G  HY   +D+W++G +FAE++   P  PG++D+DQ+ +    LG+  D           +   Q+  P +   L + FI      S+  +  + G   M+P+KR T    L+  YF  L
Sbjct:    6 EYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAA----SEYALDFMCGMLTMNPQKRWTAVQCLESDYFKEL 293

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103])

HSP 1 Score: 172.555 bits (436), Expect = 6.541e-49
Identity = 108/300 (36.00%), Postives = 160/300 (53.33%), Query Frame = 1

Query:  241 FNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRK-HHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLP-DIHKDTFRRN--KYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESY 1128
            F T   + ++Y  L  +G GA+G V       T + VAIK+  +P +   +     RE+++L+ LRH NL+ L +IF      I+ V +     L + L+ +P  L K  ++  LYQI++G++Y H + +IHRD+KP NIL+ EN  +KICDFG AR    D   T YV+TR+YR+PE+++    Y   VD+W+ GC+FAEMI   PL+PGK  + Q  +I + LGS P D+       N  K+       +P    P  E F      +  + + +L      DPKKRIT    L   Y
Sbjct:   13 FGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRP--LEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARI--QDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPI---PFSERF----KTVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Match: CDC28 (Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant [Source:SGD;Acc:S000000364])

HSP 1 Score: 166.392 bits (420), Expect = 4.928e-48
Identity = 87/223 (39.01%), Postives = 132/223 (59.19%), Query Frame = 1

Query:  271 YERLYKLGEGAYGTVFKC---RLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIF-KRKHHIHLVFQYIDHTLLQELEAKP--YKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGS 918
            Y+RL K+GEG YG V+K    R      +VA+K+         + + AIREI +L+ L+  N+V L +I     H ++LVF+++D  L + +E  P    L    +K  + Q+ +GI YCH   I+HRD+KP+N+L+ ++  +K+ DFG AR  G     YT  + T WYR+PE+L+G   Y   VD W+IGC+FAEM    P++ G S++DQ+F I   LG+
Sbjct:    8 YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGT 230

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Match: FUS3 (Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis [Source:SGD;Acc:S000000112])

HSP 1 Score: 155.992 bits (393), Expect = 1.496e-43
Identity = 97/302 (32.12%), Postives = 157/302 (51.99%), Query Frame = 1

Query:  289 LGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEI-----FKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFAR-----------PLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKD-----TFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            LGEGAYG V     K TGE+VAIK+  EP          +REI++L+  +H N++ +  I     F+  + ++++ + +   L + +  +   L+  +++  +YQ ++ ++  H SN+IHRD+KP N+L+  N  +K+CDFG AR           P G  +  T+YVATRWYR+PE+++    Y   +DVW+ GC+ AE+    P++PG+    QL LI   +G+ P    D     + R  +Y +   +       PLE+ F + N     + I +L      DP KRIT    L+  Y 
Sbjct:   19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT-PHSDNDLRCIESPRAREYIKSLPM---YPAAPLEKMFPRVN----PKGIDLLQRMLVFDPAKRITAKEALEHPYL 309

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Match: EDO49500 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGB2])

HSP 1 Score: 335.109 bits (858), Expect = 1.715e-112
Identity = 156/293 (53.24%), Postives = 214/293 (73.04%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL----GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +++E+L K+GEG+YG VFKCR K+TG++VAIK+F E +    I  +A+RE++ML+ L+HPNLV+L+E+FKRK  +HLVF+Y D T+L  L+  P  +N+  +K+I+YQ ++ +++CH  N IHRD+KPENIL+T+NY +K+CDFGFAR +    G D  YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPG+SD+DQL+LI  TLG+L   H   F +N +F G Q+PEP   +PLE  +      IS + +  + GC  M+P  R+TC+ LL   YF
Sbjct:    2 ERFEKLGKIGEGSYGVVFKCRHKETGQIVAIKKFVESEDDPLIKKIAMREVKMLKQLKHPNLVNLLEVFKRKRKLHLVFEYCDQTVLNVLDKHPNGVNEDTVKNIIYQTLKAVDFCHSHNCIHRDVKPENILITKNYIIKLCDFGFARLISRYPGED--YTDYVATRWYRAPELLVGDTAYGPPVDVWAIGCVFAELLVGQPLWPGRSDVDQLYLIKKTLGNLIPRHIQIFSQNHFFRGLQIPEPTTREPLEMKYSH----ISTDALSFMKGCLVMEPNDRLTCEELLDHKYF 288

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Match: EDO35402 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ0])

HSP 1 Score: 304.679 bits (779), Expect = 2.769e-100
Identity = 143/291 (49.14%), Postives = 206/291 (70.79%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +KYE L  +GEG+YG V KCR KD+ ++VAIK+F E +    +  +A+RE+RMLR LRH NLV+LIE+F+RK  + LVF+++DHT+L +LE  P  L+++ ++ +++Q+++ IE+ HR NIIHRD+KPENIL++ +  VK+CDFGFAR L  G    YTDYVATRWYR+PELLVGD  YG  VDVWA+GC+ AEM+   PL+PG SD+DQL+ I+   G+L   H++ F++N  F G ++P+   ++P+E  F +    IS   + +L  C +MDP +R TC  LL   +F
Sbjct:    2 EKYENLGLVGEGSYGMVMKCRHKDSNQIVAIKKFIESEDDKMVKKIAMREVRMLRQLRHENLVNLIEVFRRKKRLFLVFEFVDHTVLDDLERYPNGLDENTVRKVMWQVLRAIEFIHRHNIIHRDVKPENILVSRSGIVKLCDFGFARTLASGQGEAYTDYVATRWYRAPELLVGDTKYGRAVDVWAVGCLLAEMLTGEPLFPGDSDIDQLYHIMRCFGNLISRHREIFQKNPLFVGMRLPDIKEVEPMERRFPR----ISPMAVDMLKLCLKMDPSERPTCAQLLNHDFF 288

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BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0])

HSP 1 Score: 202.986 bits (515), Expect = 1.695e-61
Identity = 109/300 (36.33%), Postives = 172/300 (57.33%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEA-KPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNY-----IISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLN 1143
            + +E++ K+GEG YG V+K R K TG +VA+K+         + + AIREI +L+ L HPN+V L+++   +  ++LVF+++   L + ++   P  ++ S +KS +YQ++ G+ YCH   ++HRD+KP+N+L+ +N  +K+ DFG AR  G     YT  V T WYR+PE+L+G  +Y  PVDVW+IGC+FAEM     L+PG S++DQLF I  TLG+ PD        +K + G  V E  + K     +  Q+       +    I +L       P  RI+  A L   +F ++ 
Sbjct:    2 ENFEKVEKIGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQKSLYLVFEFLSQDLKKYMDCLPPSGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAFGVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGT-PD--------DKVWPG--VSELPDYKTSFPKWPVQSIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFFKDVQ 290

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Match: EDO41147 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S560])

HSP 1 Score: 196.438 bits (498), Expect = 4.533e-59
Identity = 102/291 (35.05%), Postives = 171/291 (58.76%), Query Frame = 1

Query:  268 KYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYII---SKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +Y+ + +LG+G YG+V   +   TGE VAIK+  +    +    + +RE++ LR L H N+V L E+ +   H++ VF+Y+   L Q ++ +   L +S +++++YQI+QG+ + H+    HRD+KPEN+L T +  VKI DFG AR   +   YTDYV+TRWYR+PE+L+   +Y  P+D+WA+GC+ AE+  + PL+PG S++D++F + + LG          + +++ EG ++    N K  +      + +I   S E I+++      +PKKR T    L   YF
Sbjct:    3 RYQSIKQLGDGTYGSVELAKNIQTGETVAIKKMKK-KYFSWDECINLREVKSLRKLSHTNIVKLKEVIRENDHLYFVFEYMKENLYQMMKNRDKLLPESVIRNVIYQILQGLAFIHKHGYFHRDMKPENLLCTGHELVKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAELYTLRPLFPGSSEVDEIFKVCSVLGPP--------KPDEWPEGHKLASAMNFKFPQTKATSLHSLIPNASAEAIQLMQEMLFWNPKKRPTAAQALHFPYF 284

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Match: EDO43671 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXS1])

HSP 1 Score: 182.956 bits (463), Expect = 9.592e-54
Identity = 110/304 (36.18%), Postives = 161/304 (52.96%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRH-PNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTD-NIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLG-----------SLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCN 1137
            D + ++ K+GEG YG V+K +   TG   A+K+         I + A+REI +L+ LRH PN+V L  I  ++  ++LVF+Y+   L + L+     L+K+ +KS LYQI   I +CH   I+HRD+KP+N+L+     +K+ DFG  R  G     YT  V T WYR+PE+L+G   Y  P+DVW+IG +FAEM+   PL+ G S++DQLF I   LG           SLPD +K TF +    +G +   P                +  + + +L      DP  RI+    LK  YF N
Sbjct:    2 DDFSKIEKIGEGTYGVVYKAKNLKTGGFAALKKIRLEVEDEGIPSTAVREISLLKELRHHPNVVELQHILHQEPKLYLVFEYLTCDLKKHLDTTRGMLDKTLVKSYLYQITNAIYFCHARRILHRDLKPQNLLIDSKGLIKLADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGGQRYSCPIDVWSIGTIFAEMVTKRPLFHGDSEIDQLFRIFRILGTPTEETWKGVTSLPD-YKPTFPKWA-GDGLKKAVPQ---------------LDSDGLDLLKKMLIYDPALRISAKTSLKHPYFLN 288

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:101159782])

HSP 1 Score: 350.132 bits (897), Expect = 1.217e-116
Identity = 179/365 (49.04%), Postives = 239/365 (65.48%), Query Frame = 1

Query:  250 QKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF-CNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTH-NQLTDHIISTTNNNNLYNKL 1335
            QK M +KYE++ K+GEG+YG VFKCR ++TG++VAIK+F E D    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T+   +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G  VPEP   +PLE+ +      +S++ + +L  C +MDP +R++C  LL+  YF C    S+S     + P                  K A+LP     P H  QLT   I    NN  Y+ L
Sbjct:   56 QKKM-EKYEKIAKIGEGSYGVVFKCRSRETGQIVAIKKFVESDEDPIIRKIALREIRMLKQLKHANLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRHPRGVPEHLVKSITWQTLQAVNFCHKQNCIHRDVKPENILITKQQVIKLCDFGFARILTGPGDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGIPLWPGKSDMDQLYLIRKTLGDLIPRHQQVFSTNQYFCGLPVPEPQEREPLEQKYPN----LSQQTLSLLKSCLKMDPSERLSCQQLLQHPYFSCMRERSQSSAPEPDRP----------------GNKRARLPRRPLPPGHLPQLTGSSIFPALNNRKYHDL 399

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:101159782])

HSP 1 Score: 346.665 bits (888), Expect = 1.519e-115
Identity = 165/312 (52.88%), Postives = 223/312 (71.47%), Query Frame = 1

Query:  250 QKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF-CNLNGSESVLRYSNNP 1179
            QK M +KYE++ K+GEG+YG VFKCR ++TG++VAIK+F E D    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF+Y DHT+L EL+  P  + +  +KSI +Q +Q + +CH+ N IHRD+KPENIL+T+   +K+CDFGFAR L G  + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  F  N+YF G  VPEP   +PLE+ +      +S++ + +L  C +MDP +R++C  LL+  YF C    S+S     + P
Sbjct:   56 QKKM-EKYEKIAKIGEGSYGVVFKCRSRETGQIVAIKKFVESDEDPIIRKIALREIRMLKQLKHANLVNLMEVFRRKRKLHLVFEYCDHTVLNELDRHPRGVPEHLVKSITWQTLQAVNFCHKQNCIHRDVKPENILITKQQVIKLCDFGFARILTGPGDYYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLSGIPLWPGKSDMDQLYLIRKTLGDLIPRHQQVFSTNQYFCGLPVPEPQEREPLEQKYPN----LSQQTLSLLKSCLKMDPSERLSCQQLLQHPYFSCMRERSQSSAPEPDRP 362

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Match: ENSORLT00000001547.2 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:101157382])

HSP 1 Score: 334.339 bits (856), Expect = 2.680e-111
Identity = 156/297 (52.53%), Postives = 215/297 (72.39%), Query Frame = 1

Query:  259 MRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL-GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNG 1146
            M +KYE+L K+GEG+YG VFKCR +DTG++VAIK+F E +    I  +A+REIRML+ L+H NLV+L+E+F+RK  +HLVF++ + T+L EL+  P  + ++ +KSI++Q +Q + +CH+ N IHRD+KPENILLT+   +K+CDFGFAR L G ++ YTDYVATRWYR+PELLVGD  YGPPVDVWA+GCVFAE++   PLWPGKSD+DQL+LI  TLG L   H+  FR N +F G  +P+P   +PLE+ F       S + ++++  C  MDP  R++C  LL+  YF    G
Sbjct:    3 MMEKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEEDPVIKKIALREIRMLKQLKHVNLVNLLEVFRRKRRLHLVFEFCEQTVLNELDRHPRGVPEAQLKSIVWQTLQAVNFCHKHNCIHRDVKPENILLTKTGVIKLCDFGFARILTGPEDDYTDYVATRWYRAPELLVGDTQYGPPVDVWALGCVFAELLDGNPLWPGKSDVDQLYLIRKTLGDLIPHHQQIFRSNVFFSGVSIPDPDATEPLEKRFQGA----SPQALQVMKSCLVMDPSLRLSCQELLELPYFQEEAG 295

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Match: ENSORLT00000032275.1 (probable serine/threonine-protein kinase fhkE [Source:NCBI gene;Acc:101170219])

HSP 1 Score: 299.286 bits (765), Expect = 2.325e-91
Identity = 139/292 (47.60%), Postives = 197/292 (67.47%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGT---DNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYF 1131
            +++E L  +GEG+YGTV KCR +++G LVAIK+F + D   ++  +A+REI++LR LRH NLV+L+E++KR+   +LVF+++D TLL +LE  P  LN    +  LYQI++  ++CH+ N+IHRDIKPENIL++    VK+CDFGFAR + +     +YTDYVATRWYR+PELLVGD  YG PVDVWA+GC+  EM+   PL+PG+SDLDQ+  I+   G+L   H++ F RN  F G ++PE      L++ F      I    I +   C EMDP++R  C  LL+   F
Sbjct:    2 ERFESLGPVGEGSYGTVLKCRHRESGRLVAIKKFIDSDDDKTVRKIALREIKLLRQLRHENLVNLLEVWKRRRRWYLVFEFVDRTLLNDLEQNPGGLNLDTARQYLYQILRATDFCHQQNVIHRDIKPENILISHMGVVKLCDFGFARTMTSPPESAVYTDYVATRWYRAPELLVGDFKYGKPVDVWAVGCLIIEMLTSQPLFPGESDLDQIHHIVRCFGNLMTQHQELFYRNPVFSGVKLPECSGSVSLQQRFP----TIPAAGINLAQKCLEMDPERRAQCSELLQNPLF 289

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Match: cdkl5 (cyclin-dependent kinase-like 5 [Source:NCBI gene;Acc:101174816])

HSP 1 Score: 246.128 bits (627), Expect = 3.507e-71
Identity = 128/316 (40.51%), Postives = 192/316 (60.76%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPL--GTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRK 1206
            +K+E L  +GEGAYG V KCR K+T ELVAIK+F + +    +    +RE++MLR L+  N+V L E F+R+  ++LVF+Y++  +L+ LE  P       ++S +YQ+++ I +CH++ I+HRDIKPEN+L++ N  +K+CDFGFAR L  GTD  YT+YVATRWYRSPELL+G   YG  VD+W++GC+  E+    PL+PG+S++DQLF I   LG LP      F  N  F G + P   + + LE  +     I+S   + ++     ++P +R   +  L    F  L  +E      ++P   C + RK
Sbjct:    2 NKFEVLGIVGEGAYGVVLKCRHKETNELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEEFPNGALPDKVRSYIYQLIKAINWCHKNEIVHRDIKPENLLISSNDVLKLCDFGFARNLSEGTDANYTEYVATRWYRSPELLLG-APYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHGIRFPSVTHPQTLERRY---QGILSGLLLDLMKSLLLLNPTERYLTEQSLNHPVFQPLRQAERERTSLSSPNPPCSSKRK 313

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Match: SMESG000038932.1 (SMESG000038932.1)

HSP 1 Score: 862.833 bits (2228), Expect = 0.000e+0
Identity = 410/415 (98.80%), Postives = 412/415 (99.28%), Query Frame = 1

Query:  157 AII*QMNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 1401
             ++ QMNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLN SESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF
Sbjct:  276 VVVSQMNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNSSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 690

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Match: SMESG000038932.1 (SMESG000038932.1)

HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0
Identity = 409/410 (99.76%), Postives = 409/410 (99.76%), Query Frame = 1

Query:  172 MNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 1401
            MNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLN SESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF
Sbjct:    1 MNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNSSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 410

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Match: SMESG000038932.1 (SMESG000038932.1)

HSP 1 Score: 792.341 bits (2045), Expect = 0.000e+0
Identity = 381/383 (99.48%), Postives = 382/383 (99.74%), Query Frame = 1

Query:  253 KSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 1401
            +SMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLN SESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF
Sbjct:    6 RSMRDKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNSSESVLRYSNNPRWHCEANRKQILFTDQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLPVIQTKRFTKF 388

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Match: SMESG000041875.1 (SMESG000041875.1)

HSP 1 Score: 366.696 bits (940), Expect = 1.408e-123
Identity = 174/315 (55.24%), Postives = 227/315 (72.06%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQ 1209
            DKYE++ ++GEGAYG V+KCR ++TGELVAIK+F+E +    IH +A+REIR L+ L+H NLV+LIE+FKRK  +HLVFQYIDHTLL ELE KP  L++  +  I  Q++  I +CH+ N IHRD+KPENIL+T++ QVK+CDFGFAR L   + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAEM+R  PLWPG SDLDQ++LII TLG L    K+ F+ N +F G  +PE    +PLE+ F     ++S +EI  +  CF+M+P+ R TCD LLK  YF +    E   + +  P    + NR++
Sbjct:    2 DKYEKIGQIGEGAYGVVYKCRNRETGELVAIKKFTESEDDPVIHKIAMREIRSLKQLKHENLVNLIEVFKRKRRLHLVFQYIDHTLLNELEQKPNGLDRERICKITSQLLLAIRFCHQHNCIHRDVKPENILVTKSGQVKLCDFGFARILSPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGISLPESKTQEPLEDKFTSIRPLLSSKEISFMQKCFQMEPQDRYTCDQLLKHEYFDSFPDLEDDSQATERPNRADKQNRRR 316

[Close]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Match: SMESG000041875.1 (SMESG000041875.1)

HSP 1 Score: 367.851 bits (943), Expect = 9.391e-123
Identity = 174/315 (55.24%), Postives = 227/315 (72.06%), Query Frame = 1

Query:  265 DKYERLYKLGEGAYGTVFKCRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIFKRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRSNIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPELLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSLPDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGCFEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQ 1209
            DKYE++ ++GEGAYG V+KCR ++TGELVAIK+F+E +    IH +A+REIR L+ L+H NLV+LIE+FKRK  +HLVFQYIDHTLL ELE KP  L++  +  I  Q++  I +CH+ N IHRD+KPENIL+T++ QVK+CDFGFAR L   + YTDYVATRWYR+PELLVGD  YGPPVDVWAIGCVFAEM+R  PLWPG SDLDQ++LII TLG L    K+ F+ N +F G  +PE    +PLE+ F     ++S +EI  +  CF+M+P+ R TCD LLK  YF +    E   + +  P    + NR++
Sbjct:   90 DKYEKIGQIGEGAYGVVYKCRNRETGELVAIKKFTESEDDPVIHKIAMREIRSLKQLKHENLVNLIEVFKRKRRLHLVFQYIDHTLLNELEQKPNGLDRERICKITSQLLLAIRFCHQHNCIHRDVKPENILVTKSGQVKLCDFGFARILSPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGISLPESKTQEPLEDKFTSIRPLLSSKEISFMQKCFQMEPQDRYTCDQLLKHEYFDSFPDLEDDSQATERPNRADKQNRRR 404

The following BLAST results are available for this feature:

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Zebrafish
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Mouse
BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CDKL1	1.281e-118	52.24	cyclin dependent kinase like 1 [Source:HGNC Symbol...	[more]
CDKL4	1.077e-113	45.62	cyclin dependent kinase like 4 [Source:HGNC Symbol...	[more]
CDKL4	1.821e-113	51.10	cyclin dependent kinase like 4 [Source:HGNC Symbol...	[more]
CDKL1	4.224e-106	57.14	cyclin dependent kinase like 1 [Source:HGNC Symbol...	[more]
CDKL2	5.408e-93	45.45	cyclin dependent kinase like 2 [Source:HGNC Symbol...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdkl-1	3.251e-108	52.23	Cyclin-dependent kinase-like 1 [Source:UniProtKB/...	[more]
cdkl-1	4.804e-108	52.23	Cyclin-dependent kinase-like 1 [Source:UniProtKB/...	[more]
cdkl-1	6.508e-108	52.23	Cyclin-dependent kinase-like 1 [Source:UniProtKB/...	[more]
dyf-5	3.116e-60	35.23	Serine/threonine-protein kinase dyf-5 [Source:Uni...	[more]
dyf-5	4.403e-60	35.23	Serine/threonine-protein kinase dyf-5 [Source:Uni...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG7236	2.554e-110	49.27	gene:FBgn0031730 transcript:FBtr0343387	[more]
CG7236	9.459e-109	51.94	gene:FBgn0031730 transcript:FBtr0343388	[more]
CG7236	3.378e-108	51.94	gene:FBgn0031730 transcript:FBtr0302950	[more]
CG7236	3.864e-108	51.94	gene:FBgn0031730 transcript:FBtr0343389	[more]
Cdk7	1.311e-59	36.49	gene:FBgn0263237 transcript:FBtr0070756	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdkl1	4.576e-117	54.30	cyclin-dependent kinase-like 1 (CDC2-related kinas...	[more]
cdkl5	8.972e-71	40.39	cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZD...	[more]
cdkl5	8.972e-71	40.39	cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZD...	[more]
cdkl5	8.972e-71	40.39	cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZD...	[more]
cdkl5	1.485e-70	40.39	cyclin-dependent kinase-like 5 [Source:ZFIN;Acc:ZD...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CDKL1	3.291e-113	54.14	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
CDKL1	1.467e-106	51.89	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
vsx2	7.063e-89	47.23	visual system homeobox 2 [Source:Xenbase;Acc:XB-GE...	[more]
vldlr	8.301e-71	39.62	very low density lipoprotein receptor [Source:Xenb...	[more]
vldlr	5.267e-64	37.74	very low density lipoprotein receptor [Source:Xenb...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cdkl4	2.872e-116	54.67	cyclin-dependent kinase-like 4 [Source:MGI Symbol;...	[more]
Cdkl4	2.872e-116	54.67	cyclin-dependent kinase-like 4 [Source:MGI Symbol;...	[more]
Cdkl4	2.872e-116	54.67	cyclin-dependent kinase-like 4 [Source:MGI Symbol;...	[more]
Cdkl1	1.261e-114	49.72	cyclin-dependent kinase-like 1 (CDC2-related kinas...	[more]
Cdkl2	1.033e-89	47.95	cyclin-dependent kinase-like 2 (CDC2-related kinas...	[more]

BLAST of Cyclin dependent kinase like 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q00532\|CDKL1_HUMAN	5.229e-118	52.24	Cyclin-dependent kinase-like 1 OS=Homo sapiens OX=...	[more]
sp\|Q3TZA2\|CDKL4_MOUSE	2.009e-115	54.67	Cyclin-dependent kinase-like 4 OS=Mus musculus OX=...	[more]
sp\|Q6AXJ9\|CDKL1_DANRE	7.197e-115	53.97	Cyclin-dependent kinase-like 1 OS=Danio rerio OX=7...	[more]
sp\|Q8CEQ0\|CDKL1_MOUSE	8.821e-114	49.72	Cyclin-dependent kinase-like 1 OS=Mus musculus OX=...	[more]
sp\|Q5MAI5\|CDKL4_HUMAN	5.170e-113	45.62	Cyclin-dependent kinase-like 4 OS=Homo sapiens OX=...	[more]

BLAST of Cyclin dependent kinase like 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267DKM9	1.333e-126	53.50	Protein kinase domain-containing protein OS=Macros...	[more]
A0A267E989	1.486e-126	53.50	Protein kinase domain-containing protein OS=Macros...	[more]
A0A267ER40	1.409e-122	56.72	Protein kinase domain-containing protein OS=Macros...	[more]
A0A1I8J290	2.665e-122	58.28	Protein kinase domain-containing protein OS=Macros...	[more]
A0A267FJ04	6.362e-122	57.19	Protein kinase domain-containing protein OS=Macros...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdkl1	1.087e-113	55.17	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
ENSAMXT00000057054.1	8.363e-112	52.36	cyclin-dependent kinase-like 1 [Source:NCBI gene;A...	[more]
ENSAMXT00000052448.1	8.363e-112	52.36	cyclin-dependent kinase-like 1 [Source:NCBI gene;A...	[more]
cdkl1	1.426e-109	53.79	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
ENSAMXT00000033332.1	6.369e-105	51.35	cyclin-dependent kinase-like 1 [Source:NCBI gene;A...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdk2	4.473e-64	38.69	cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN...	[more]
cdk2	3.288e-62	35.91	cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN...	[more]
cdk7	2.330e-59	37.13	cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GEN...	[more]
ENSPMAT00000003004.1	1.031e-58	36.64	pep scaffold:Pmarinus_7.0:GL476686:67050:81358:1 g...	[more]
mak	8.483e-57	36.45	male germ cell-associated kinase [Source:ZFIN;Acc:...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
PHO85	7.904e-53	32.26	Cyclin-dependent kinase; has ten cyclin partners; ...	[more]
KIN28	9.809e-53	32.19	Serine/threonine protein kinase, subunit of transc...	[more]
HOG1	6.541e-49	36.00	Mitogen-activated protein kinase involved in osmor...	[more]
CDC28	4.928e-48	39.01	Cyclin-dependent kinase (CDK) catalytic subunit; m...	[more]
FUS3	1.496e-43	32.12	Mitogen-activated serine/threonine protein kinase ...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49500	1.715e-112	53.24	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35402	2.769e-100	49.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41403	1.695e-61	36.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41147	4.533e-59	35.05	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43671	9.592e-54	36.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdkl1	1.217e-116	49.04	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
cdkl1	1.519e-115	52.88	cyclin dependent kinase like 1 [Source:NCBI gene;A...	[more]
ENSORLT00000001547.2	2.680e-111	52.53	cyclin-dependent kinase-like 1 [Source:NCBI gene;A...	[more]
ENSORLT00000032275.1	2.325e-91	47.60	probable serine/threonine-protein kinase fhkE [Sou...	[more]
cdkl5	3.507e-71	40.51	cyclin-dependent kinase-like 5 [Source:NCBI gene;A...	[more]

BLAST of Cyclin dependent kinase like 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000038932.1	0.000e+0	98.80	SMESG000038932.1	[more]
SMESG000038932.1	0.000e+0	99.76	SMESG000038932.1	[more]
SMESG000038932.1	0.000e+0	99.48	SMESG000038932.1	[more]
SMESG000041875.1	1.408e-123	55.24	SMESG000041875.1	[more]
SMESG000041875.1	9.391e-123	55.24	SMESG000041875.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30006225 ID=SMED30006225|Name=Cyclin dependent kinase like 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1501bp
GGATCGTAATATTTACAGAGTATTTGGAAAATAAATATTGCAGTTCTCAT
TTATGTATAAATAAAAATAAATAAATACAAAAATTACAGTTATTAGCTCA
TTATCAGTTTTCTATTTACAATTTCATTTTTGCTTCGAAATATTTCTCAT
TAGAATGCAATCATATAACAGATGAACACATTGAATAGTTTTGTTCGTTC
CAAACAAATTTGCGAGTTACCTCGCTCACTTGATCGAAAGTTTAATACAC
AAAAGTCAATGCGGGATAAGTATGAAAGACTATACAAACTCGGAGAAGGA
GCATATGGGACTGTCTTTAAATGTCGTTTAAAAGACACAGGTGAATTGGT
TGCCATCAAAAGATTCAGTGAACCAGATACAATAACCAGTATTCATAACA
TGGCCATTAGAGAAATAAGGATGTTACGACTATTGCGTCATCCAAATTTG
GTGCATTTAATTGAAATTTTCAAAAGAAAACATCATATACATCTAGTATT
CCAATACATTGACCATACTTTGCTGCAAGAACTTGAGGCAAAACCATACA
AGTTGAACAAATCCAATATGAAAAGTATTCTTTATCAAATAGTACAAGGA
ATTGAATATTGTCATAGATCAAATATAATTCACCGAGATATTAAACCAGA
AAATATCCTTTTAACAGAAAATTATCAAGTAAAAATTTGTGATTTTGGAT
TTGCTCGTCCATTGGGAACGGATAATATTTATACAGATTACGTAGCTACC
CGGTGGTATCGCAGTCCCGAGTTACTAGTTGGCGATATCCATTATGGGCC
CCCAGTAGATGTATGGGCAATTGGATGTGTGTTTGCTGAAATGATTAGAA
TTTGCCCGCTTTGGCCGGGAAAATCTGACCTTGATCAATTATTTCTTATA
ATAAATACTCTCGGGAGTCTTCCAGACATTCACAAAGACACATTCAGAAG
AAATAAGTACTTTGAAGGATTTCAGGTTCCAGAGCCATGCAATTTGAAAC
CATTGGAAGAGAATTTCATACAACAGAATTACATTATATCCAAAGAAGAA
ATAAAAATATTGCATGGATGCTTTGAAATGGATCCAAAGAAACGAATCAC
GTGTGATGCACTGCTTAAAGAATCATATTTTTGTAATCTCAATGGTTCAG
AATCAGTTTTGCGTTATTCAAATAATCCAAGATGGCATTGCGAAGCAAAC
AGAAAACAAATTTTATTTACAGATCAAAATAAAAAGGTAGCGAAATTGCC
TTCTCTTATTTATTATCCTACCCATAACCAATTAACAGACCACATCATAT
CTACGACAAATAATAACAACTTATATAACAAATTGGAAATAACCGAAAAG
AAGTTGTTACCAAGATTACCGGTCATTCAAACAAAAAGATTTACAAAGTT
TTGATAACATTTCAGTTTATGATTATTTGTCTTCTTGTATTATTAAGAGT
ATTATAAAATTGAAACATTTATTTGGATAATTGAATTGTTTATCTACTTG
C

protein sequence of SMED30006225-orf-1

>SMED30006225-orf-1 ID=SMED30006225-orf-1|Name=SMED30006225-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=411bp
MNTLNSFVRSKQICELPRSLDRKFNTQKSMRDKYERLYKLGEGAYGTVFK
CRLKDTGELVAIKRFSEPDTITSIHNMAIREIRMLRLLRHPNLVHLIEIF
KRKHHIHLVFQYIDHTLLQELEAKPYKLNKSNMKSILYQIVQGIEYCHRS
NIIHRDIKPENILLTENYQVKICDFGFARPLGTDNIYTDYVATRWYRSPE
LLVGDIHYGPPVDVWAIGCVFAEMIRICPLWPGKSDLDQLFLIINTLGSL
PDIHKDTFRRNKYFEGFQVPEPCNLKPLEENFIQQNYIISKEEIKILHGC
FEMDPKKRITCDALLKESYFCNLNGSESVLRYSNNPRWHCEANRKQILFT
DQNKKVAKLPSLIYYPTHNQLTDHIISTTNNNNLYNKLEITEKKLLPRLP
VIQTKRFTKF*

Aliases

The feature 'Cyclin dependent kinase like 1' has the following synonyms


Synonym
cdkl1

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000017	photoreceptor neuron
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0007507	heart development
GO:0016310	phosphorylation
GO:0051726	regulation of cell cycle

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular exosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 34..320 e-value: 5.5E-92 score: 321.6
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 34..320 e-value: 8.1E-74 score: 248.3
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 34..320 score: 45.714
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 30..114 e-value: 3.1E-28 score: 99.7
None	No IPR available	PFAM	PF12330	Haspin_kinase	coord: 13..181 e-value: 1.1E-6 score: 27.8
None	No IPR available	PIRSF	PIRSF000654	ILK	coord: 13..263 e-value: 4.5E-19 score: 66.1
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 115..323 e-value: 5.1E-61 score: 207.9
None	No IPR available	PANTHER	PTHR24056	CELL DIVISION PROTEIN KINASE	coord: 32..339
None	No IPR available	PANTHER	PTHR24056:SF192	CYCLIN-DEPENDENT KINASE-LIKE 1	coord: 32..339
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 152..164
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 40..63
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 28..323