Peptidyl-prolyl cis-trans isomerase

Overview
NamePeptidyl-prolyl cis-trans isomerase
Smed IDSMED30006182
Length (bp)713
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Peptidyl-prolyl cis-trans isomerase (SMED30006182) t-SNE clustered cells

Violin plots show distribution of expression levels for Peptidyl-prolyl cis-trans isomerase (SMED30006182) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Peptidyl-prolyl cis-trans isomerase (SMED30006182) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Peptidyl-prolyl cis-trans isomerase (SMED30006182) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30006182

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30006182h1SMcG0017600 SmedASXL_008028SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30006182h1SMcG0017600 dd_Smed_v4_4606_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30006182h1SMcG0017600 dd_Smed_v4_4606_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30006182h1SMcG0017600 dd_Smed_v4_4606_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30006182h1SMcG0017600 dd_Smed_v4_4606_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Match: PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988])

HSP 1 Score: 185.267 bits (469), Expect = 5.911e-59
Identity = 89/158 (56.33%), Postives = 112/158 (70.89%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  + +           V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 163
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Match: PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988])

HSP 1 Score: 185.267 bits (469), Expect = 5.911e-59
Identity = 89/158 (56.33%), Postives = 112/158 (70.89%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  + +           V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 163
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Match: PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988])

HSP 1 Score: 132.494 bits (332), Expect = 2.733e-39
Identity = 61/86 (70.93%), Postives = 71/86 (82.56%), Query Frame = 3 
Query:  261 ITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    5 ITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 90
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Match: PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988])

HSP 1 Score: 123.635 bits (309), Expect = 4.356e-35
Identity = 63/123 (51.22%), Postives = 80/123 (65.04%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRG 413
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  + +           V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RG
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRG 128
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Match: PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:HGNC Symbol;Acc:HGNC:8992])

HSP 1 Score: 50.447 bits (119), Expect = 1.687e-7
Identity = 30/77 (38.96%), Postives = 42/77 (54.55%), Query Frame = 3 
Query:  279 EALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EA+E LKS           F  +A Q+S+   A++GGDLG   RG M  PF++ +F+L V  M  P++TD  V   F
Sbjct:   53 EAMEKLKS--------GMRFNEVAAQYSE-DKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKF 120
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Celegans
Match: pinn-1 (Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:Q9N492])

HSP 1 Score: 157.147 bits (396), Expect = 1.694e-48
Identity = 80/154 (51.95%), Postives = 107/154 (69.48%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN----VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGG---DCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFR 512
            LP+GW ++QS    + YY N  T  SQW+ P  +A        SV+C HLL+K+  SR  SSWR   ITR+K++A+ +LK+YE++++     +  F  LA+QFSDCSSAKRGGDLG F+R QMQKPFED SF+L++GEMS  + T SGVHLI+R
Sbjct:    6 LPAGWEKRQSRSNDRVYYFNTATGRSQWERPDESAFGKGSELKSVQCLHLLVKHDGSRNPSSWRSDHITRSKDDAINILKNYEKELKDASNIEGKFRELAKQFSDCSSAKRGGDLGPFERRQMQKPFEDASFALEIGEMSDIVDTSSGVHLIYR 159
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Celegans
Match: pinn-4 (Peptidyl-prolyl cis-trans isomerase [Source:UniProtKB/TrEMBL;Acc:Q9NAF9])

HSP 1 Score: 48.1358 bits (113), Expect = 3.495e-7
Identity = 30/84 (35.71%), Postives = 45/84 (53.57%), Query Frame = 3 
Query:  258 VITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            ++   + +ALE +    EK++ G   F  +A Q+S+   A+ GGDLG   RG M  PF+D +F+L       PI+TD  V   F
Sbjct:   38 ILCEKQGKALEAI----EKLKSG-MKFNEVAAQYSE-DKARSGGDLGWMTRGSMVGPFQDAAFALSNSSCDKPIYTDPPVKTKF 115
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Fly
Match: dod (gene:FBgn0015379 transcript:FBtr0077193)

HSP 1 Score: 167.548 bits (423), Expect = 2.588e-52
Identity = 88/164 (53.66%), Postives = 107/164 (65.24%), Query Frame = 3 
Query:   63 MP---QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-----------VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFR 512
            MP   QLP GW ++ S  TG  YY+N+YT+ESQWD PT  A+               V C HLL+K+K SRR SSWREA ITRTKEEA  LL+ Y  KI   + +F  LA  +SDCSSAKRGGDLG F RGQMQ  FED +F L V ++SG + +DSG+H+I R
Sbjct:    1 MPDAEQLPDGWEKRTSRSTGMSYYLNMYTKESQWDQPTEPAKKAGGGSAGGGDAPDEVHCLHLLVKHKGSRRPSSWREANITRTKEEAQLLLEVYRNKIVQQEATFDELARSYSDCSSAKRGGDLGKFGRGQMQAAFEDAAFKLNVNQLSGIVDSDSGLHIILR 164
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Fly
Match: CG32845 (gene:FBgn0052845 transcript:FBtr0072518)

HSP 1 Score: 97.8265 bits (242), Expect = 1.560e-23
Identity = 56/168 (33.33%), Postives = 86/168 (51.19%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAA----------------AENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE*N 524
            +LP GW E+ +  T + Y+ +  T++  +  P +                 ++ N  ++C H+L+K+ +S R SS+RE ++ RTK+EAL  +    + I+ G   FA LA   SDC SA+ GGDLG     Q    FE     LK GE+S    T +G H++ RT  N
Sbjct:   72 KLPFGWEERIAHSTKECYFYDTITRKVHFTLPPSHHREKDRNAWGAILGDYSDFNDQLRCRHILVKHSESDRCSSYRERMVRRTKQEALNKIMHARDLIQSGKFEFAELANMISDCCSARHGGDLGPLSLTQTPFVFERNILLLKDGELSEIFQTKAGYHILLRTPIN 239
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Fly
Match: CG11858 (gene:FBgn0039305 transcript:FBtr0084815)

HSP 1 Score: 48.521 bits (114), Expect = 3.802e-7
Identity = 26/73 (35.62%), Postives = 42/73 (57.53%), Query Frame = 3 
Query:  309 EKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDS------GVHLIF 509
            EK++ G   F  +A  +S+   A++GGDLG   RG M  PF+D +F+L +  ++ P++TD       G H+I 
Sbjct:   55 EKLKAGQ-KFPEVAAAYSE-DKARQGGDLGWQIRGAMVGPFQDAAFALPISTVNNPVYTDPPIKTKFGYHIIM 125
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Zebrafish
Match: pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1714])

HSP 1 Score: 177.178 bits (448), Expect = 2.723e-56
Identity = 83/140 (59.29%), Postives = 106/140 (75.71%), Query Frame = 3 
Query:  108 TGKPYYVNIYTQESQWDFPTAAAENNVS----VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            +G+ YY N  T  SQW+ P+ +  +       V+CSHLL+K+  SRR SSWRE  ITR+K+EAL+L++ Y E+I+ G+  F SLA QFSDCSSA+ GGDLG F RGQMQKPFED SF+LKVG+MSGP++TDSGVH+I RT
Sbjct:    1 SGRVYYFNHITNASQWERPSGSGADGAGDVEKVRCSHLLVKHSQSRRPSSWREENITRSKDEALQLIQKYIEQIKSGEEEFESLASQFSDCSSARNGGDLGLFGRGQMQKPFEDASFALKVGDMSGPVFTDSGVHIILRT 140
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Zebrafish
Match: pin4 (protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) [Source:NCBI gene;Acc:553574])

HSP 1 Score: 54.6842 bits (130), Expect = 2.872e-9
Identity = 28/67 (41.79%), Postives = 41/67 (61.19%), Query Frame = 3 
Query:  309 EKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EKI+ G   F+ +A Q+S+   A++GGDLG   RG M  PF+D +F+L +  M  P++TD  V   F
Sbjct:   53 EKIKSG-MRFSEVAAQYSE-DKARQGGDLGWMTRGSMVGPFQDAAFALPISTMDKPVYTDPPVKTKF 117
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Xenopus
Match: pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:NCBI gene;Acc:493472])

HSP 1 Score: 186.422 bits (472), Expect = 1.422e-59
Identity = 89/154 (57.79%), Postives = 111/154 (72.08%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS----VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ PT   +N       V+CSHLL+K+  SRR SSWR+  ITRTK+EALE +  Y +KI+ GD  F SLA +FSDCSSAK GGDLG F RG MQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHMTNASQWERPTTGGKNGQGEPGKVRCSHLLVKHNQSRRPSSWRQDRITRTKDEALEHINGYIQKIKSGDEDFESLASRFSDCSSAKAGGDLGSFGRGAMQKPFEDASFALRPGEMSGPVFTDSGIHIILRTE 159
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Xenopus
Match: pin4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:NCBI gene;Acc:394809])

HSP 1 Score: 55.4546 bits (132), Expect = 2.350e-9
Identity = 31/77 (40.26%), Postives = 43/77 (55.84%), Query Frame = 3 
Query:  279 EALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EA+E LKS           F+ +A Q+S+   A++GGDLG   RG M  PF+D +F+L V  M  P++TD  V   F
Sbjct:   49 EAMEKLKS--------GVRFSEVATQYSE-DKARQGGDLGWMTRGSMVGPFQDAAFALPVSTMDKPVYTDPPVKTKF 116
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Mouse
Match: Pin1rt1 (protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 [Source:MGI Symbol;Acc:MGI:3649546])

HSP 1 Score: 182.185 bits (461), Expect = 5.439e-58
Identity = 87/155 (56.13%), Postives = 110/155 (70.97%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN-----VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW +  S  +G+ YY N  T  SQW+ P+  +  N       V+CSHLL+K+  SRR SSWR+  ITR+KEEALEL+  Y  KI+ G+  F SLA QFSDCSSAK  GDLG F RGQM+KPFED SF+L+ GEMSGP++T+SG+H+I RTE
Sbjct:    5 KLPPGWKKYMSRSSGREYYFNHITNASQWERPSEGSSKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIRKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMEKPFEDASFALRTGEMSGPVFTESGIHIILRTE 159
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Mouse
Match: Pin1 (protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 [Source:MGI Symbol;Acc:MGI:1346036])

HSP 1 Score: 181.03 bits (458), Expect = 2.044e-57
Identity = 88/160 (55.00%), Postives = 111/160 (69.38%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN----------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  +               V+CSHLL+K+  SRR SSWR+  ITR+KEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGSSKNGQGEPAKVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGPFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 165
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Mouse
Match: Pin4 (protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) [Source:MGI Symbol;Acc:MGI:1916963])

HSP 1 Score: 51.2174 bits (121), Expect = 5.654e-8
Identity = 30/77 (38.96%), Postives = 43/77 (55.84%), Query Frame = 3 
Query:  279 EALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EA+E LKS           F+ +A Q+S+   A++GGDLG   RG M  PF++ +F+L V  M  P++TD  V   F
Sbjct:   53 EAMEKLKS--------GMRFSEVATQYSE-DKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKF 120
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Match: sp|Q13526|PIN1_HUMAN (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 2.838e-58
Identity = 89/158 (56.33%), Postives = 112/158 (70.89%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  + +           V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 163
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Match: sp|Q5BIN5|PIN1_BOVIN (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Bos taurus OX=9913 GN=PIN1 PE=2 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 2.901e-58
Identity = 89/158 (56.33%), Postives = 112/158 (70.89%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  +  +          V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSGSGKNGQGEPTRVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 163
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Match: sp|P0C1J8|PIN1_RHIO9 (Peptidyl-prolyl cis-trans isomerase pin1 OS=Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) OX=246409 GN=pin1 PE=3 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 1.654e-57
Identity = 85/148 (57.43%), Postives = 109/148 (73.65%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LP  WI + S    K YY N  T ES+WD P    E    V+ SHLLIK+++SRR SSWRE  ITR+KEEAL++L  ++ KI  G  + ++LA  +SDC+SAKRGGDLG+F+RGQMQKPFE+ +F+L+VGE+S P+WTDSGVHLI RT
Sbjct:    3 LPENWIVRHSRTYNKDYYYNTVTNESRWDAPVLKGELE-RVRASHLLIKSRESRRPSSWREEHITRSKEEALKILTDFQHKIESGQETLSALATNYSDCTSAKRGGDLGYFERGQMQKPFEEATFALQVGELSKPVWTDSGVHLILRT 149
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Match: sp|Q4R383|PIN1_MACFA (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Macaca fascicularis OX=9541 GN=PIN1 PE=2 SV=1)

HSP 1 Score: 182.185 bits (461), Expect = 3.919e-57
Identity = 88/158 (55.70%), Postives = 111/158 (70.25%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN--------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  + + YY N  T  SQW+ P+  + +           V+CSHLL+K+  SRR SSWR+  ITRTKEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSDRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 163
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Match: sp|Q9QUR7|PIN1_MOUSE (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Mus musculus OX=10090 GN=Pin1 PE=1 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 1.430e-56
Identity = 88/160 (55.00%), Postives = 111/160 (69.38%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN----------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +LP GW ++ S  +G+ YY N  T  SQW+ P+  +               V+CSHLL+K+  SRR SSWR+  ITR+KEEALEL+  Y +KI+ G+  F SLA QFSDCSSAK  GDLG F RGQMQKPFED SF+L+ GEMSGP++TDSG+H+I RTE
Sbjct:    6 KLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGSSKNGQGEPAKVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGPFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 165
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Match: D6WFG9 (Peptidyl-prolyl cis-trans isomerase OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC003825 PE=4 SV=1)

HSP 1 Score: 209.534 bits (532), Expect = 1.829e-65
Identity = 101/154 (65.58%), Postives = 122/154 (79.22%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-----VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            QLP+GW ++ S  TG+ YY+N+YT+ESQWD P   AE   S     V+CSHLL+K+KDSRR SSWRE  ITRTK+EALEL+KSY E+I  G  SFA LA ++SDCSSAKRGGDLG FKRG MQKPFE+ SF+LKVGE+S P++TDSGVH+I RT
Sbjct:    5 QLPTGWEKRLSRSTGQHYYLNVYTKESQWDVPDKPAEPVSSSGPEQVQCSHLLVKHKDSRRPSSWREENITRTKDEALELVKSYREQIVQGKASFADLASKYSDCSSAKRGGDLGSFKRGAMQKPFEEASFALKVGELSEPVFTDSGVHIILRT 158
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Match: J3JX40 (Peptidyl-prolyl cis-trans isomerase OS=Dendroctonus ponderosae OX=77166 PE=2 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 4.998e-64
Identity = 100/153 (65.36%), Postives = 120/153 (78.43%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-----VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LP GW ++ S  TG+ YY+NIYT+ESQWD P+  AE   S     V+CSHLL+K+KDSRR SSWRE VITR+KEEALEL+K Y E+I  G  SFA LA ++SDCSSAKRGGDLG F +G MQKPFED +FSLKVGE+S P++TDSGVH+I RT
Sbjct:    6 LPVGWEKRLSRSTGQHYYLNIYTKESQWDAPSEPAERGQSSGPDQVQCSHLLVKHKDSRRPSSWREEVITRSKEEALELVKMYREQIAQGKASFAELATKYSDCSSAKRGGDLGPFGKGAMQKPFEDSAFSLKVGELSDPVFTDSGVHIILRT 158
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Match: A0A1W4XGV6 (Peptidyl-prolyl cis-trans isomerase OS=Agrilus planipennis OX=224129 GN=LOC108744199 PE=4 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 3.267e-63
Identity = 100/153 (65.36%), Postives = 120/153 (78.43%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-----VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LP+GW ++ S  TG+ YY+NIYT+ESQWD P   AE   S     V+CSHLL+K+KDSRR SSWRE  ITRTKEEALEL+KSY E+I  G  SFA LA++ SDCSSAKRGGDLG F +G MQKPFE+ +FSLKVGE+S P++TDSGVH+I RT
Sbjct:    6 LPAGWEKRLSRSTGQHYYLNIYTKESQWDVPDKPAEPANSAGPEQVQCSHLLVKHKDSRRPSSWREEHITRTKEEALELVKSYREQIVHGKASFADLAQKCSDCSSAKRGGDLGPFGKGAMQKPFEEAAFSLKVGELSDPVFTDSGVHIILRT 158
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Match: A0A1D2N8B3 (Peptidyl-prolyl cis-trans isomerase OS=Orchesella cincta OX=48709 GN=Ocin01_05198 PE=4 SV=1)

HSP 1 Score: 202.601 bits (514), Expect = 1.085e-62
Identity = 95/154 (61.69%), Postives = 120/154 (77.92%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAA-----ENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            +P GW ++ S  TG+ YY+N+YT+ESQWD PT AA          ++ SH+L+K+++SRR SSWRE  ITR+KEEALE+L  + EKI GG+ SFA LA ++SDCSSAKRGGDLG F RG MQKPFED +F+LKVGEMSGP++TDSGVH+I RTE
Sbjct:    7 VPPGWEKRVSRSTGQAYYLNMYTKESQWDKPTKAATPVSPSGPSKIQASHILVKHRESRRPSSWREENITRSKEEALEILMGHREKIVGGEVSFAELAAKYSDCSSAKRGGDLGPFARGAMQKPFEDAAFALKVGEMSGPVFTDSGVHIILRTE 160
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Match: A0A1S3JNA8 (Peptidyl-prolyl cis-trans isomerase OS=Lingula unguis OX=7574 GN=LOC106174559 PE=4 SV=1)

HSP 1 Score: 201.445 bits (511), Expect = 2.183e-62
Identity = 95/149 (63.76%), Postives = 117/149 (78.52%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LP+GW  K S  TG+ YY+N++T+ES W+ PT  AE  +  V+CSHLL+K++ SRR SSWRE  ITRTK+EAL++LK Y +KI  G+ SF  LA QFSDCSSAK+GGDLG F RGQMQKPFE+  FSLKVGE+S P+WTDSGVH+I RT
Sbjct:    5 LPAGWEAKTSRSTGRTYYLNVHTKESIWEKPTRPAEKGMDQVRCSHLLVKHRQSRRPSSWREDNITRTKDEALDILKGYRDKIVSGEASFEQLASQFSDCSSAKKGGDLGLFGRGQMQKPFEEAGFSLKVGELSEPVWTDSGVHIILRT 153
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Cavefish
Match: pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:NCBI gene;Acc:103047339])

HSP 1 Score: 187.193 bits (474), Expect = 4.399e-60
Identity = 88/152 (57.89%), Postives = 115/152 (75.66%), Query Frame = 3 
Query:   69 QLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNV---SVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            +LPSGW ++ S  +G+ YY N  T  SQW+ P+ A E       V+CSHLL+K+  SRR SSWRE  ITR+KEEAL+L++ Y E+I+ G+  F +LA +FSDCSSA+ GGDLG F RGQMQKPFE+ SF+LK+G+MSGP++TDSGVH+I RT
Sbjct:    6 KLPSGWEKRMSRSSGRVYYFNHSTNASQWERPSGAGEGAGVVDKVRCSHLLVKHNQSRRPSSWREENITRSKEEALQLIQKYIEQIKSGEEDFETLASRFSDCSSARNGGDLGMFGRGQMQKPFEEASFALKIGDMSGPVFTDSGVHIILRT 157
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Cavefish
Match: pin4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:NCBI gene;Acc:103035627])

HSP 1 Score: 55.4546 bits (132), Expect = 1.178e-9
Identity = 31/77 (40.26%), Postives = 43/77 (55.84%), Query Frame = 3 
Query:  279 EALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EA+E LKS           F+ LA Q+S+   A++GGDLG   RG M  PF+D +F+L +  M  P++TD  V   F
Sbjct:   50 EAMEKLKS--------GVRFSELASQYSE-DKARQGGDLGWMTRGSMVGPFQDAAFALPISTMDKPVYTDPPVKTKF 117
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Sea Lamprey
Match: pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1714])

HSP 1 Score: 167.933 bits (424), Expect = 2.761e-53
Identity = 78/138 (56.52%), Postives = 102/138 (73.91%), Query Frame = 3 
Query:  108 TGKPYYVNIYTQESQWDFPTAAAENN--VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
             G+ YY N  T  SQW+ P   +  +    V+CSHLL+K+  SRR SSWRE  ITR+K+EA+ +L+ Y  +IR G+ SF  LA ++SDCSSAK+GGDLG F RGQMQKPFED S+++ VGEMSGP++T+SGVH+I RT
Sbjct:   19 AGRVYYFNHVTNSSQWERPEGGSRGDEPSQVRCSHLLVKHSGSRRPSSWREEHITRSKDEAVSILQEYIRQIRSGEVSFEELASKYSDCSSAKKGGDLGFFSRGQMQKPFEDASYAMAVGEMSGPVFTESGVHIIQRT 156
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Yeast
Match: ESS1 (Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants [Source:SGD;Acc:S000003778])

HSP 1 Score: 120.553 bits (301), Expect = 9.308e-35
Identity = 68/159 (42.77%), Postives = 96/159 (60.38%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENN---------VSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGD--CSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LP+ W  + S    + Y+ N  T+ SQW+ P    ++          V V+C H+LIK+KDSRR +S R   IT +K++A + LK+   ++       SF +LA++ SDCSS KRGGDLG F RG+MQ  FED +F LKVGE+S  + + SGVH+I R 
Sbjct:   11 LPTPWTVRYSKSKKREYFFNPETKHSQWEEPEGTNKDQLHKHLRDHPVRVRCLHILIKHKDSRRPASHRSENITISKQDATDELKTLITRLDDDSKTNSFEALAKERSDCSSYKRGGDLGWFGRGEMQPSFEDAAFQLKVGEVSDIVESGSGVHVIKRV 169
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Nematostella
Match: EDO37326 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG38])

HSP 1 Score: 186.422 bits (472), Expect = 2.663e-60
Identity = 88/151 (58.28%), Postives = 114/151 (75.50%), Query Frame = 3 
Query:   63 MPQLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            M  LP GW+EK S+ TGK YY+N +T+ SQW+ PT  A + V  + SHLL+K+ +SRR SSW+   ITR+K+EAL +LK Y+E+I+ G+ +   LA+  SDCSSAK GGDLG F RGQMQKPFE  +FSL+VGEMS P++TDSG+HLI RT
Sbjct:    1 MSSLPPGWVEKVSNSTGKTYYLNQHTKASQWERPTEPAGDQV--RASHLLVKHSESRRPSSWKTDKITRSKDEALAILKGYQEQIKSGEATLEDLAKTESDCSSAKNGGDLGFFGRGQMQKPFETATFSLRVGEMSEPVFTDSGIHLILRT 149
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Nematostella
Match: EDO26281 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TCF2])

HSP 1 Score: 103.219 bits (256), Expect = 8.191e-29
Identity = 46/71 (64.79%), Postives = 57/71 (80.28%), Query Frame = 3 
Query:  303 YEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            Y+E+I+ G+ +   LA+  SDCSSAK GGDLG F RGQMQKPFE  +FSL+VGEMS P++TDSG+HLI RT
Sbjct:    2 YQEQIKSGEATLEDLAKTESDCSSAKNGGDLGFFGRGQMQKPFETATFSLRVGEMSEPVFTDSGIHLILRT 72
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Nematostella
Match: EDO36374 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIW4])

HSP 1 Score: 46.2098 bits (108), Expect = 6.272e-7
Identity = 35/118 (29.66%), Postives = 56/118 (47.46%), Query Frame = 3 
Query:  156 DFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            D  + A +   SVK  H+L + K S+               EA+E LK+ ++        F  +A  +S+   A++GGDLG   RG M  PF++ +F L+   +  P++TD  V   F
Sbjct:    3 DGASKAKKGGTSVKVRHILCE-KHSKAM-------------EAMEKLKAGQK--------FNEVATAYSE-DKARQGGDLGWMTRGSMVGPFQEAAFELQTSTVDRPVYTDPPVKTKF 97
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Medaka
Match: pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:NCBI gene;Acc:101165866])

HSP 1 Score: 191.045 bits (484), Expect = 1.280e-61
Identity = 93/149 (62.42%), Postives = 111/149 (74.50%), Query Frame = 3 
Query:   72 LPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVS-VKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRT 515
            LPSGW ++ S  +GK YY N  T  SQW+ P          V+CSHLL+K+  SRR SSWRE  ITRTKEEA+EL++ Y ++I+ G  SF SLA QFSDCSSAK GGDLG F RGQMQKPFED SF+LKVG+MSGP++TDSGVH+I RT
Sbjct:    7 LPSGWEKRMSRSSGKVYYFNHITNASQWERPVGDGRGEPDKVRCSHLLVKHNQSRRPSSWREQNITRTKEEAIELIQKYIDEIKSGHESFESLASQFSDCSSAKNGGDLGLFARGQMQKPFEDASFNLKVGDMSGPVFTDSGVHIILRT 155
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Medaka
Match: pin4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:NCBI gene;Acc:101160079])

HSP 1 Score: 52.7582 bits (125), Expect = 1.268e-8
Identity = 26/67 (38.81%), Postives = 41/67 (61.19%), Query Frame = 3 
Query:  309 EKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EK++ G   F+ +A Q+S+   A++GGDLG   RG M  PF++ +F+L +  M  P++TD  V   F
Sbjct:   52 EKLKAG-VRFSEVASQYSE-DKARQGGDLGWMTRGSMVGPFQEAAFALPISSMDKPVYTDPPVKTKF 116
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Medaka
Match: pin4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:NCBI gene;Acc:101160079])

HSP 1 Score: 51.9878 bits (123), Expect = 2.891e-8
Identity = 26/67 (38.81%), Postives = 41/67 (61.19%), Query Frame = 3 
Query:  309 EKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIF 509
            EK++ G   F+ +A Q+S+   A++GGDLG   RG M  PF++ +F+L +  M  P++TD  V   F
Sbjct:   60 EKLKAG-VRFSEVASQYSE-DKARQGGDLGWMTRGSMVGPFQEAAFALPISSMDKPVYTDPPVKTKF 124
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Planmine SMEST
Match: SMESG000057818.1 (SMESG000057818.1)

HSP 1 Score: 318.546 bits (815), Expect = 3.182e-112
Identity = 152/152 (100.00%), Postives = 152/152 (100.00%), Query Frame = 3 
Query:   63 MPQLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 518
            MPQLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE
Sbjct:    1 MPQLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLLIKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFRTE 152
[Close]
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Planmine SMEST
Match: SMESG000064735.1 (SMESG000064735.1)

HSP 1 Score: 52.373 bits (124), Expect = 1.265e-8
Identity = 31/83 (37.35%), Postives = 42/83 (50.60%), Query Frame = 3 
Query:  279 EALELLKSYEEKIRGGDCSFASLAEQFSDCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDS------GVHLIF 509
            EA+E LKS           F  +AEQ+S+   A+ GGDLG   RG M  PF+D +F L +  +  P +TD       G H+I 
Sbjct:   49 EAMEKLKS--------GVKFNQVAEQYSE-DKARSGGDLGWMTRGSMVGPFQDAAFELPISSLDNPKYTDPPIKTKFGYHIIM 122
The following BLAST results are available for this feature:
BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PIN15.911e-5956.33peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
PIN15.911e-5956.33peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
PIN12.733e-3970.93peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
PIN14.356e-3551.22peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
PIN41.687e-738.96peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pinn-11.694e-4851.95Peptidyl-prolyl cis-trans isomerase [Source:UniPr... [more]
pinn-43.495e-735.71Peptidyl-prolyl cis-trans isomerase [Source:UniPr... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dod2.588e-5253.66gene:FBgn0015379 transcript:FBtr0077193[more]
CG328451.560e-2333.33gene:FBgn0052845 transcript:FBtr0072518[more]
CG118583.802e-735.62gene:FBgn0039305 transcript:FBtr0084815[more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pin12.723e-5659.29peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
pin42.872e-941.79protein (peptidylprolyl cis/trans isomerase) NIMA-... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pin11.422e-5957.79peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
pin42.350e-940.26peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Pin1rt15.439e-5856.13protein (peptidyl-prolyl cis/trans isomerase) NIMA... [more]
Pin12.044e-5755.00protein (peptidyl-prolyl cis/trans isomerase) NIMA... [more]
Pin45.654e-838.96protein (peptidyl-prolyl cis/trans isomerase) NIMA... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q13526|PIN1_HUMAN2.838e-5856.33Peptidyl-prolyl cis-trans isomerase NIMA-interacti... [more]
sp|Q5BIN5|PIN1_BOVIN2.901e-5856.33Peptidyl-prolyl cis-trans isomerase NIMA-interacti... [more]
sp|P0C1J8|PIN1_RHIO91.654e-5757.43Peptidyl-prolyl cis-trans isomerase pin1 OS=Rhizop... [more]
sp|Q4R383|PIN1_MACFA3.919e-5755.70Peptidyl-prolyl cis-trans isomerase NIMA-interacti... [more]
sp|Q9QUR7|PIN1_MOUSE1.430e-5655.00Peptidyl-prolyl cis-trans isomerase NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
D6WFG91.829e-6565.58Peptidyl-prolyl cis-trans isomerase OS=Tribolium c... [more]
J3JX404.998e-6465.36Peptidyl-prolyl cis-trans isomerase OS=Dendroctonu... [more]
A0A1W4XGV63.267e-6365.36Peptidyl-prolyl cis-trans isomerase OS=Agrilus pla... [more]
A0A1D2N8B31.085e-6261.69Peptidyl-prolyl cis-trans isomerase OS=Orchesella ... [more]
A0A1S3JNA82.183e-6263.76Peptidyl-prolyl cis-trans isomerase OS=Lingula ung... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pin14.399e-6057.89peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
pin41.178e-940.26peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pin12.761e-5356.52peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ESS19.308e-3542.77Peptidylprolyl-cis/trans-isomerase (PPIase); speci... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO373262.663e-6058.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO262818.191e-2964.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO363746.272e-729.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
pin11.280e-6162.42peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
pin41.268e-838.81peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
pin42.891e-838.81peptidylprolyl cis/trans isomerase, NIMA-interacti... [more]
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BLAST of Peptidyl-prolyl cis-trans isomerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000057818.13.182e-112100.00SMESG000057818.1[more]
SMESG000064735.11.265e-837.35SMESG000064735.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30006182 ID=SMED30006182|Name=Peptidyl-prolyl cis-trans isomerase|organism=Schmidtea mediterranea sexual|type=transcript|length=713bp
AGTACAACCATTTAAGATTTTATAAAAATTAATTTTTTGTAATAATTTAA
TATTAATTAAAAATGCCACAATTACCTAGTGGATGGATTGAGAAACAATC
GTCAAGAACTGGAAAACCCTATTATGTAAATATTTATACTCAAGAAAGTC
AATGGGATTTTCCAACAGCTGCAGCGGAAAATAATGTTTCAGTGAAATGT
TCGCATTTACTTATTAAAAACAAAGATTCTCGCCGTGCTTCCTCTTGGAG
AGAAGCTGTCATCACACGAACCAAAGAAGAAGCATTAGAGTTATTAAAAA
GTTATGAAGAAAAAATCCGTGGCGGTGATTGCTCATTTGCAAGTTTGGCA
GAGCAATTTAGTGATTGTTCGTCGGCAAAACGAGGTGGAGATCTAGGCCA
TTTCAAACGTGGTCAAATGCAAAAACCCTTTGAAGATGTCAGTTTCTCTT
TAAAAGTTGGAGAAATGAGTGGTCCAATTTGGACTGATAGTGGAGTGCAT
TTAATTTTCCGTACCGAATAAAATCTTACTTGAAATTTATACACTAAATA
AAAGTTCCATTTGATGTATGCATGTTAAATTCCAAAATTTATTGTTCATT
TGATGGGATGTATTTCACTTTCCTTAAAAATGTATCTGGCATTTTGTTGG
ATTTACCATTAATTTCATTGCAATTTGTTGGAAAAATAAGATTTTCGTTT
GAAGTTATATCAA
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protein sequence of SMED30006182-orf-1

>SMED30006182-orf-1 ID=SMED30006182-orf-1|Name=SMED30006182-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=153bp
MPQLPSGWIEKQSSRTGKPYYVNIYTQESQWDFPTAAAENNVSVKCSHLL
IKNKDSRRASSWREAVITRTKEEALELLKSYEEKIRGGDCSFASLAEQFS
DCSSAKRGGDLGHFKRGQMQKPFEDVSFSLKVGEMSGPIWTDSGVHLIFR
TE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR036020WW_dom_sf
IPR001202WW_dom
IPR000297PPIase_PpiC
IPR023058PPIase_PpiC_CS
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0016853isomerase activity
GO:0003755peptidyl-prolyl cis-trans isomerase activity
Vocabulary: biological process
TermDefinition
GO:0000413protein peptidyl-prolyl isomerization
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001202WW domainSMARTSM00456ww_5coord: 3..36
e-value: 1.0E-7
score: 41.6
IPR001202WW domainPFAMPF00397WWcoord: 4..34
e-value: 6.2E-12
score: 45.4
IPR001202WW domainPROSITEPS01159WW_DOMAIN_1coord: 8..34
IPR001202WW domainPROSITEPS50020WW_DOMAIN_2coord: 2..36
score: 13.654
IPR001202WW domainCDDcd00201WWcoord: 5..35
e-value: 1.3359E-8
score: 45.9818
IPR000297Peptidyl-prolyl cis-trans isomerase, PpiC-typePFAMPF00639Rotamasecoord: 48..150
e-value: 2.9E-23
score: 82.7
IPR000297Peptidyl-prolyl cis-trans isomerase, PpiC-typePROSITEPS50198PPIC_PPIASE_2coord: 41..152
score: 28.668
NoneNo IPR availableGENE3DG3DSA:3.10.50.40coord: 38..152
e-value: 6.3E-47
score: 161.0
NoneNo IPR availableGENE3DG3DSA:2.20.70.10coord: 1..37
e-value: 6.5E-12
score: 47.0
NoneNo IPR availablePANTHERPTHR10657:SF4PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATEDcoord: 1..152
NoneNo IPR availablePANTHERPTHR10657PEPTIDYL-PROLYL CIS-TRANS ISOMERASEcoord: 1..152
NoneNo IPR availableSUPERFAMILYSSF54534FKBP-likecoord: 43..152
IPR023058Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved sitePROSITEPS01096PPIC_PPIASE_1coord: 92..112
IPR036020WW domain superfamilySUPERFAMILYSSF51045WW domaincoord: 2..36