slc24a-4
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30006161 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of slc24a-4 vs. Ensembl Human
Match: SLC24A2 (solute carrier family 24 member 2 [Source:HGNC Symbol;Acc:HGNC:10976]) HSP 1 Score: 224.557 bits (571), Expect = 7.230e-65 Identity = 148/431 (34.34%), Postives = 231/431 (53.60%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK----RCNRNW--DKCCYQSKVEPLKEEDDD-----------------IFLNSLIKYDRRNTLINVISLPAEKRMSLPA------FSRXXXXXXXXXXXXXXXXKPVIQCCNLCN----MCPPIRGSPPKYSDYM------VELPTT-ESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y Y+ FM FN ++ K NRN +++ +P D D NSL++ +I+ + AE R A + + E+ ++ + I+ N + M P S P + + E T E S W K + F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R P+++ S
Sbjct: 153 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS 583
BLAST of slc24a-4 vs. Ensembl Human
Match: SLC24A5 (solute carrier family 24 member 5 [Source:HGNC Symbol;Acc:HGNC:20611]) HSP 1 Score: 203.371 bits (516), Expect = 3.325e-58 Identity = 134/402 (33.33%), Postives = 213/402 (52.99%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY-------QSKVEPLK--EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQ 1592
CD++F+PSLE++SE L LS DVAG TFMAAGSS+PEL ++ V + D+GI TI GSA++NLL I + +S +V L P+ RDCA Y IS ++ ++D + WY+ ++LLIY Y+ + F+ KI + + CC +S+ +PL E++ F+ + D + + S ++ +SL S+ + PP + +P + R I +V++ P + + T DC K+ +K YF+++FF+S +W+ + T+ +V +VT G + + VM L +LAAG+S+PD + S++VAR+G GDMA+SN +GSNVFD+ LGIP+ IK IN +P + S+
Sbjct: 87 CDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTD--SGIFYEDSGYSQLSISLHGLSQ-------------------------------VSEDPPS----VFNMPEADLKR--------------IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR 436
BLAST of slc24a-4 vs. Ensembl Human
Match: SLC24A5 (solute carrier family 24 member 5 [Source:HGNC Symbol;Acc:HGNC:20611]) HSP 1 Score: 179.874 bits (455), Expect = 4.427e-50 Identity = 126/397 (31.74%), Postives = 202/397 (50.88%), Query Frame = 3
Query: 435 VPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY-------QSKVEPLK--EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQ 1592
+P + L LS DVAG TFMAAGSS+PEL ++ V + D+GI TI GSA++NLL I + +S +V L P+ RDCA Y IS ++ ++D + WY+ ++LLIY Y+ + F+ KI + + CC +S+ +PL E++ F+ + D + + S ++ +SL S+ + PP + +P + R I +V++ P + + T DC K+ +K YF+++FF+S +W+ + T+ +V +VT G + + VM L +LAAG+S+PD + S++VAR+G GDMA+SN +GSNVFD+ LGIP+ IK IN +P + S+
Sbjct: 32 LPQRLPRATALGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTD--SGIFYEDSGYSQLSISLHGLSQ-------------------------------VSEDPPS----VFNMPEADLKR--------------IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR 376
BLAST of slc24a-4 vs. Ensembl Human
Match: SLC24A2 (solute carrier family 24 member 2 [Source:HGNC Symbol;Acc:HGNC:10976]) HSP 1 Score: 140.584 bits (353), Expect = 8.985e-35 Identity = 75/166 (45.18%), Postives = 107/166 (64.46%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK----RCNRNW--DKCCYQSKVEPLKEEDDD 896
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y Y+ FM FN ++ K NRN +++ +P D D
Sbjct: 153 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQAKPSAARDKD 318 HSP 2 Score: 114.005 bits (284), Expect = 5.345e-26 Identity = 59/171 (34.50%), Postives = 102/171 (59.65%), Query Frame = 3
Query: 1077 NMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
N+ I G+ + +D + P + + W K + F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R P+++ S
Sbjct: 438 NLSHNIEGAEAQTADEEEDQPLSLA--------WPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS 600
BLAST of slc24a-4 vs. Ensembl Human
Match: SLC24A4 (solute carrier family 24 member 4 [Source:HGNC Symbol;Acc:HGNC:10978]) HSP 1 Score: 135.191 bits (339), Expect = 8.538e-34 Identity = 68/134 (50.75%), Postives = 93/134 (69.40%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI 818
CDDFFVPSLE + E+L LS DVAGATFMAAGSS+PELF+S+ V DVG+GTI GSAVFN+L II + + V++L W + RD +Y IS+ LI ++D I W++ +V++++Y YI M +N K+
Sbjct: 3 CDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKM 136 HSP 2 Score: 115.161 bits (287), Expect = 7.309e-27 Identity = 57/135 (42.22%), Postives = 93/135 (68.89%), Query Frame = 3
Query: 1191 LKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
+KW V +P + + TI +C+K +++K+F+++F + LW+ ++ MV +VT IG + + +M + LAAG+S+PD + SLIVAR+G GDMAVSN IGSNVFDI GLG+P+ ++ +++N GS + + S+
Sbjct: 291 VKW---VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR 422
BLAST of slc24a-4 vs. Ensembl Celegans
Match: ncx-4 (Na/Ca eXchangers [Source:UniProtKB/TrEMBL;Acc:Q1ZXT5]) HSP 1 Score: 199.904 bits (507), Expect = 1.335e-56 Identity = 132/409 (32.27%), Postives = 219/409 (53.55%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNA---KIMKRCNRNWDKCCYQSKV----EPLKEEDDDI--------------------FLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILIN 1562
CD+FFVPSL+V++EKL LS DVAGATFMAAG S+PE F+S+ V +++VGIGTI GSA FN+L +++ SKS+L L W P+ RD + Y++++ L+F D +I + +A+ M IY Y T M FN +++K+ + + + ++++ P ++D+ L+S + RN ++ +++ E+ LP S S + + N+ P R S + ++E + + W +K + +V+ P ++ TI D K + + +F +SILW+ ++ MV IG + + ++ L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ LI
Sbjct: 120 CDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLTWWPLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNGQLEQLVKKGSDSEEASAHETQKLAADVPHNNNNNDLAQLEGSELRRRSSARRQSVPILHSGTMF--RNGIMQLMNQTLEQ---LPEDSEEDDSSRSRSNVNIESHD--MHRLNVNQSMPDRRSSQIEEIKSLLEEQEEKPLDMTWPETW----VKRLTYVLLAPVVIPMWVTIPDVRKSHNRGLYPATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIE 517
BLAST of slc24a-4 vs. Ensembl Celegans
Match: ncx-5 (Na/Ca eXchangers [Source:UniProtKB/TrEMBL;Acc:G5EC02]) HSP 1 Score: 123.25 bits (308), Expect = 1.977e-29 Identity = 65/132 (49.24%), Postives = 88/132 (66.67%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESD-VGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNA 812
CD+FFVPSL V++E L +S DVAGATFMAAG S+PE F+S+ V D VG+GTI GSA FN+L +++ S+ VL L W P+ RD +FY +S+ L+ D +I W +A+VM +Y +Y FM FN
Sbjct: 117 CDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNILCVLAFCTLFSRQVLHLTWWPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYGFFMKFNG 248 HSP 2 Score: 102.449 bits (254), Expect = 1.186e-22 Identity = 51/123 (41.46%), Postives = 80/123 (65.04%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILIN 1562
K +I++ P +YT+ D K +K+F ++F +ILW+ + ++ MV IG + + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS++IGSN+FD+ GL IP++I I
Sbjct: 457 KKLIYLFLAPITFPLAYTLPDVRKPSLRKFFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCVGLPIPWLIHFAIG 579
BLAST of slc24a-4 vs. Ensembl Celegans
Match: ncx-4 (Na/Ca eXchangers [Source:UniProtKB/TrEMBL;Acc:Q1ZXT5]) HSP 1 Score: 70.8626 bits (172), Expect = 3.082e-14 Identity = 32/58 (55.17%), Postives = 48/58 (82.76%), Query Frame = 3
Query: 1389 VMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILIN 1562
++ L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ LI
Sbjct: 18 IIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIE 75
BLAST of slc24a-4 vs. Ensembl Celegans
Match: ncx-6 (Putative sodium/calcium exchanger 6 [Source:UniProtKB/Swiss-Prot;Acc:P34315]) HSP 1 Score: 68.9366 bits (167), Expect = 4.469e-12 Identity = 43/149 (28.86%), Postives = 81/149 (54.36%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV----TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSV--HDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDK 848
DDFF PS+ + L++S VAG TFMA G+ +P++F +IA+V T ++D+ +G + G+ +F + + L+ + K + RD AFYL+++ +L F +D + W + L +Y Y+ ++ + + R ++ +K
Sbjct: 118 ADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSPTPKADLALGELFGAGLF--VTTMVLAVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFCFVYYDHVEIWM-PITFLGVYLIYVCTVILSQILHNRHKKDEEK 263 HSP 2 Score: 58.151 bits (139), Expect = 1.010e-8 Identity = 33/97 (34.02%), Postives = 59/97 (60.82%), Query Frame = 3
Query: 1293 SFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISL 1583
F +SI W+ ++ +V +VT +G + V+ V+ L +LA +S+ DL+ + VA++G MA++ AIG +F++ G G+PF I + +G IS+
Sbjct: 435 GFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGLPFTIAKI--QGKSISM 529
BLAST of slc24a-4 vs. Ensembl Celegans
Match: ncx-8 (Na/Ca eXchangers [Source:UniProtKB/TrEMBL;Acc:O16241]) HSP 1 Score: 66.2402 bits (160), Expect = 3.103e-11 Identity = 50/166 (30.12%), Postives = 86/166 (51.81%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF----ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSV--HDTIINWYDAVVMLLIYASY-ITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDD 896
DDFF PS+ + LK+S +AG TF+A G+ +P++F SI++V ++ + +G + G+++F V++++ + K+ P RD FY+I++ ++ F D I W A L IYA Y +T + F+ +R N K + L+ E DD
Sbjct: 123 ADDFFCPSISGIVTHLKMSESIAGVTFLAFGNGAPDVFGSISSVLSTPKPKAALALGDLFGTSIFVTTVVLAI--IIFTKSFKVAIIPTLRDLIFYMITLAFITFCFLKFDKIEVWMPA-TFLGIYAVYLLTVIAFSIYRTRRKNLK--------KKKQLESEKDD 277 HSP 2 Score: 51.2174 bits (121), Expect = 1.725e-6 Identity = 24/95 (25.26%), Postives = 53/95 (55.79%), Query Frame = 3
Query: 1263 KQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMI 1547
K + Y + F +SI W+ + ++ ++T +G + ++ ++ L V++ + D++ + V ++G MA++ AIG +F++ G G+PF I
Sbjct: 538 KYHKEVYSYLGFLMSIAWIYATANEIISVMTMVGVVTGLSQELLGLTVMSWSDCIGDIVADIAVIKQGYPKMAMAAAIGGPLFNLLIGFGLPFTI 632
BLAST of slc24a-4 vs. Ensembl Fly
Match: Nckx30C (gene:FBgn0028704 transcript:FBtr0079928) HSP 1 Score: 143.28 bits (360), Expect = 1.011e-35 Identity = 78/159 (49.06%), Postives = 111/159 (69.81%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEED 890
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++ + C + K ++KV ++ D
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV-ETCVK---KMITKNKVTRVRSTD 504 HSP 2 Score: 98.9821 bits (245), Expect = 2.399e-21 Identity = 56/151 (37.09%), Postives = 88/151 (58.28%), Query Frame = 3
Query: 1137 PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 648 PEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 797
BLAST of slc24a-4 vs. Ensembl Fly
Match: Nckx30C (gene:FBgn0028704 transcript:FBtr0079926) HSP 1 Score: 143.28 bits (360), Expect = 1.011e-35 Identity = 78/159 (49.06%), Postives = 111/159 (69.81%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEED 890
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++ + C + K ++KV ++ D
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV-ETCVK---KMITKNKVTRVRSTD 504 HSP 2 Score: 98.9821 bits (245), Expect = 2.399e-21 Identity = 56/151 (37.09%), Postives = 88/151 (58.28%), Query Frame = 3
Query: 1137 PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 648 PEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 797
BLAST of slc24a-4 vs. Ensembl Fly
Match: Nckx30C (gene:FBgn0028704 transcript:FBtr0303908) HSP 1 Score: 143.28 bits (360), Expect = 1.021e-35 Identity = 78/159 (49.06%), Postives = 111/159 (69.81%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEED 890
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++ + C + K ++KV ++ D
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV-ETCVK---KMITKNKVTRVRSTD 504 HSP 2 Score: 100.523 bits (249), Expect = 6.987e-22 Identity = 56/156 (35.90%), Postives = 91/156 (58.33%), Query Frame = 3
Query: 1122 YMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
+ ++ P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 668 FSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 822
BLAST of slc24a-4 vs. Ensembl Fly
Match: Nckx30C (gene:FBgn0028704 transcript:FBtr0303909) HSP 1 Score: 142.51 bits (358), Expect = 1.669e-35 Identity = 73/135 (54.07%), Postives = 100/135 (74.07%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI 818
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV 484 HSP 2 Score: 100.908 bits (250), Expect = 6.813e-22 Identity = 56/156 (35.90%), Postives = 91/156 (58.33%), Query Frame = 3
Query: 1122 YMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
+ ++ P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 659 FSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 813
BLAST of slc24a-4 vs. Ensembl Fly
Match: Nckx30C (gene:FBgn0028704 transcript:FBtr0335506) HSP 1 Score: 142.51 bits (358), Expect = 1.697e-35 Identity = 73/135 (54.07%), Postives = 100/135 (74.07%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI 818
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV 484 HSP 2 Score: 98.9821 bits (245), Expect = 2.444e-21 Identity = 56/151 (37.09%), Postives = 88/151 (58.28%), Query Frame = 3
Query: 1137 PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 639 PEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 788
BLAST of slc24a-4 vs. Ensembl Zebrafish
Match: slc24a4b (solute carrier family 24 member 4b [Source:ZFIN;Acc:ZDB-GENE-081031-75]) HSP 1 Score: 231.106 bits (588), Expect = 1.609e-67 Identity = 153/419 (36.52%), Postives = 233/419 (55.61%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDK------CCYQSKVEPLKEED----------DDIFLNSLIKY-----DRRNTLINVISLPAEKRMS---LPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMV--ELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKIL-INRGSPISLFSQ 1592
CDD+FV SLE + EKL LS DVAGATFMAAGSS+PELF+S+ V DVG+GTI GSAVFN+L II + + V+ L W + RD FY++S+ LI ++D I W++++V++++YA YI M FN+++ K R +K S++E +K D+I S Y R + N RM+ + + + + E + KP I+ N+ P + + K S+ LP +R KW+I ++P L++ +TI +C K +++KYF++SF +S +W+ ++ MV +VT IG + + +M + LAAG+S+PD + SLIVAR+G GDMAVSN IGSNVFDI GLG+P+ ++ + +N GS + + S+
Sbjct: 171 CDDYFVTSLEKICEKLNLSEDVAGATFMAAGSSAPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGIFAGQVVLLTWWAVFRDSFFYILSVVALIVFIYDEKIVWWESLVLVVMYACYILIMKFNSRLQKFFTRKGNKNVANGNAAAGSELEDVKTSKIYSRGSVVMVDEIINASPPNYRFPEAGLRVMVTNHFGPKTRLRMASRLIITERQRLVQSANGVETAVVDGKPDIENGNV----PEDKSTEEKESELTTPFRLPDGCMNR-----------TKWLI---SWPLLLILFFTIPNCAKSRWEKYFMLSFILSTVWIAVFSYFMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCIASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWALQTMAVNYGSVVMINSR 571
BLAST of slc24a-4 vs. Ensembl Zebrafish
Match: CABZ01081780.1 (sodium/potassium/calcium exchanger 2-like [Source:NCBI gene;Acc:571043]) HSP 1 Score: 217.238 bits (552), Expect = 5.736e-63 Identity = 147/399 (36.84%), Postives = 221/399 (55.39%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKR-CNRNW-DKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVI-SLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVEL--PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY+I + LI D II + +++ +LL YA+Y+ FM FN + +KR NRN + Q KV +K F N+ + R + ++ SL L + E S K + C + + + D + L P + RF+ +L+IL + FP + T+ D K KK+F ++F +I W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ ++N P+ + S
Sbjct: 125 CDEFFVPALTVITEKLTISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSKEILNLTWWPLFRDVSFYIIGLIMLIVFFLDNIITYCESISLLLAYAAYVLFMKFNGNVETLVKRMMNRNQVVEVEAQPKVNRMKH-----FENARPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLSEGKFREKASILHKIAKKKCQVEDSNGVAGAEEDEEDDQPLSLSWPESCQKRFT-----YLFILP-----IVFPLWI----TLPDVRKPTSKKFFPVTFLGAICWIAGFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLFSMVNGMVPVQVSS 504
BLAST of slc24a-4 vs. Ensembl Zebrafish
Match: CABZ01081780.1 (sodium/potassium/calcium exchanger 2-like [Source:NCBI gene;Acc:571043]) HSP 1 Score: 216.853 bits (551), Expect = 9.778e-63 Identity = 147/399 (36.84%), Postives = 221/399 (55.39%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKR-CNRNW-DKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVI-SLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVEL--PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY+I + LI D II + +++ +LL YA+Y+ FM FN + +KR NRN + Q KV +K F N+ + R + ++ SL L + E S K + C + + + D + L P + RF+ +L+IL + FP + T+ D K KK+F ++F +I W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ ++N P+ + S
Sbjct: 134 CDEFFVPALTVITEKLTISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSKEILNLTWWPLFRDVSFYIIGLIMLIVFFLDNIITYCESISLLLAYAAYVLFMKFNGNVETLVKRMMNRNQVVEVEAQPKVNRMKH-----FENARPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLSEGKFREKASILHKIAKKKCQVEDSNGVAGAEEDEEDDQPLSLSWPESCQKRFT-----YLFILP-----IVFPLWI----TLPDVRKPTSKKFFPVTFLGAICWIAGFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLFSMVNGMVPVQVSS 513
BLAST of slc24a-4 vs. Ensembl Zebrafish
Match: slc24a2 (solute carrier family 24 member 2 [Source:ZFIN;Acc:ZDB-GENE-060825-277]) HSP 1 Score: 208.764 bits (530), Expect = 1.806e-59 Identity = 136/414 (32.85%), Postives = 225/414 (54.35%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI-----MKRCNRNWDKCCYQSKVEPLKEEDDDI--------------FLNSLIKYDRRNTLINVISLPAEKRMSLPA-FSRXXXXXXXXXXXXXXXXKPVIQCCNL-CNMCPPIRGSP-PKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQ 1592
CD+FFVP+L V++EKL++S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY+I + LI D I + ++ +L Y SY+TFM FN+ + + D KV + ++++ + N+L++ +I+ + +E + A ++ + +E K + N+ + PP+ GS P+ E + + W I K + ++ FP + ++ D ++ +K+F ++F SI W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ ++N S +++ S
Sbjct: 150 CDEFFVPALTVITEKLEISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIIGLIMLIVFFLDNYITYVESFALLSCYGSYVTFMKFNSSVETWIKTRLLGNQVDDIEAPPKVVSVPDDENKLSAKPRLQRGGSSASLHNTLMRNSIFQLMIHTLDPLSEGKFKEKASILHKIARKKGQDEANGVVDKNLPNSSNVEVEVTPPMNGSAGPEVEVEEEEEDEDQPLSLA----WPDTIRKQVTYLFIFPIVFPLWLSLPDVRRESSRKFFPVTFLGSISWIAFFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLFSMLNDFSSVAVSSN 559
BLAST of slc24a-4 vs. Ensembl Zebrafish
Match: slc24a5 (solute carrier family 24 member 5 [Source:ZFIN;Acc:ZDB-GENE-031210-1]) HSP 1 Score: 199.519 bits (506), Expect = 6.950e-57 Identity = 125/400 (31.25%), Postives = 208/400 (52.00%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY--------QSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFS 1589
CD++F+PSLEV+SE+L LS DVAGATFMAAGSS+PEL ++ V + D+G+ TI GSAV+NLL I + +S +V +L P+ RDC Y IS+ +I + D + WYD +LL+Y Y+ + F+ KI + + + CC+ + +PL DD L + + + S + +SL + + SD + + H R + W++ + P + ++ DC + +K +++++F +S +W+ + T+ +V +VT +G + + VM + +LAAG+S+PD + S++VAREG DMA+SN +GSNVFD+ LG+P+ I+ + ++ GSP+ + S
Sbjct: 99 CDEYFLPSLEVISERLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIMGSAVYNLLCICAACGLLSSAVGRLSCWPLFRDCVAYSISVAAVIAIISDNRVYWYDGACLLLVYGVYVAVLCFDLKISEYVMQRFSPCCWCLKPRDRDSGEQQPLVGWSDDSSLRVQRRSRNDSGIFQDDSGYSHLSLSLHGLN--------------------------------------EISDEHKSVFSMPDHDLKR--------ILWVL---SLPVSTLLFVSVPDCRRPFWKNFYMLTFLMSAVWISAFTYVLVWMVTIVGETLGIPDTVMGMTLLAAGTSIPDTVASVMVAREGKSDMAMSNIVGSNVFDMLC-LGLPWFIQTVFVDVGSPVDVNS 448
BLAST of slc24a-4 vs. Ensembl Xenopus
Match: nt5c3a (5'-nucleotidase, cytosolic IIIA [Source:Xenbase;Acc:XB-GENE-1004833]) HSP 1 Score: 229.565 bits (584), Expect = 3.238e-67 Identity = 150/423 (35.46%), Postives = 234/423 (55.32%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK--RCNRN-WDKCCYQSKVEPLKEED-----------DDIFLNSLIKYDRRNTLINVI---SLPAEKRMSLPA------FSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQKERVSLI 1613
CDDFFVPSLE + EKL LS DVAGATFMAAGSS+PELF+S+ V DVG+GTI GSAVFN+L II + + V++L W + RD +Y+ISI LI ++D II W+++++++++Y YI M +N K+ + +N + C S+++ +K D+I +S KY + ++ P R+ + + R + D + +++ L K DY E FS + I KW ++P + + +TI +C+K +++ +F+++F S LW+ ++ MV +VT IG + + +M + LAAG+S+PD + SLIVAR+G GDMAVSN+IGSNVFDI GLG+P+ ++ ++IN GS + + S+ S+I
Sbjct: 125 CDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGVFAGQVVRLTWWSLFRDSMYYIISILALIIFIYDEIIVWWESLILIVMYFFYILIMKYNTKMQRLFTIKKNVGNGCPVGSELQDVKASQQYYNRNSVVMVDEIICSSPPKYRFPEAGLRIMITNKFPPRTRLRMASRLIINERQRLLHSANGTSTTTLDGKQELLENGGL---------HVDKADDYQEENEANYLVPFSVPS-GCANIFKW---AFSWPLICILYFTIPNCSKPRWENFFMLTFITSTLWIAIFSYIMVWMVTVIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNSIGSNVFDILVGLGVPWGLQTMIINYGSTVKINSKGLVYSVI 534
BLAST of slc24a-4 vs. Ensembl Xenopus
Match: SLC24A5 (solute carrier family 24 member 5 [Source:NCBI gene;Acc:100490024]) HSP 1 Score: 207.994 bits (528), Expect = 2.641e-60 Identity = 135/393 (34.35%), Postives = 213/393 (54.20%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
C+ +F+PSLEV+SE+L LS DVAGATFMA GSS+PE + V + D+G+ TI GSAV+NLL I + +S SV +L P+ RDC Y IS+ +I D I WY++ ++LIY YI M F+ +I + R + CC + + + + L K SLP R I ++ SD + I L +PP + +P + LK II+V++ P + + T+ DC ++++K F+++F +S +W+ ++T+ +V +VT +G +++ VM L +LAAG+S+PD + S++VAREG GDMA+SN +GSNVFD+ LG+P+ IK + ++R +P+ + S
Sbjct: 55 CESYFIPSLEVISERLGLSQDVAGATFMAIGSSAPEFVTVFLGVFVTKGDIGVSTIVGSAVYNLLGICAACCLLSLSVSRLTCWPLFRDCVAYAISVAAVIAITFDNRIYWYESASLILIYGIYIVTMCFDIRINQYIMRRFSPCCTCCREAMVGNTEHEPLL-------------------GWKEDSLPVIRRHSRSDSGIFQEESDYSQLSISLSGL----KESSNNPPS----VFTMPEND--------------LKRIIWVLSLPIITLLYLTVPDCRRKRWKNLFILTFLMSAVWISAVTYILVWMVTVVGETLSIPDTVMGLTLLAAGTSIPDTVASVLVAREGKGDMAMSNIVGSNVFDM-LCLGVPWFIKTVFVDRSAPVEVNSS 405
BLAST of slc24a-4 vs. Ensembl Xenopus
Match: SLC24A5 (solute carrier family 24 member 5 [Source:NCBI gene;Acc:100490024]) HSP 1 Score: 207.608 bits (527), Expect = 2.947e-60 Identity = 135/393 (34.35%), Postives = 213/393 (54.20%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
C+ +F+PSLEV+SE+L LS DVAGATFMA GSS+PE + V + D+G+ TI GSAV+NLL I + +S SV +L P+ RDC Y IS+ +I D I WY++ ++LIY YI M F+ +I + R + CC + + + + L K SLP R I ++ SD + I L +PP + +P + LK II+V++ P + + T+ DC ++++K F+++F +S +W+ ++T+ +V +VT +G +++ VM L +LAAG+S+PD + S++VAREG GDMA+SN +GSNVFD+ LG+P+ IK + ++R +P+ + S
Sbjct: 49 CESYFIPSLEVISERLGLSQDVAGATFMAIGSSAPEFVTVFLGVFVTKGDIGVSTIVGSAVYNLLGICAACCLLSLSVSRLTCWPLFRDCVAYAISVAAVIAITFDNRIYWYESASLILIYGIYIVTMCFDIRINQYIMRRFSPCCTCCREAMVGNTEHEPLL-------------------GWKEDSLPVIRRHSRSDSGIFQEESDYSQLSISLSGL----KESSNNPPS----VFTMPEND--------------LKRIIWVLSLPIITLLYLTVPDCRRKRWKNLFILTFLMSAVWISAVTYILVWMVTVVGETLSIPDTVMGLTLLAAGTSIPDTVASVLVAREGKGDMAMSNIVGSNVFDM-LCLGVPWFIKTVFVDRSAPVEVNSS 399
BLAST of slc24a-4 vs. Ensembl Xenopus
Match: SLC24A5 (solute carrier family 24 member 5 [Source:NCBI gene;Acc:100490024]) HSP 1 Score: 207.994 bits (528), Expect = 3.545e-60 Identity = 135/393 (34.35%), Postives = 213/393 (54.20%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
C+ +F+PSLEV+SE+L LS DVAGATFMA GSS+PE + V + D+G+ TI GSAV+NLL I + +S SV +L P+ RDC Y IS+ +I D I WY++ ++LIY YI M F+ +I + R + CC + + + + L K SLP R I ++ SD + I L +PP + +P + LK II+V++ P + + T+ DC ++++K F+++F +S +W+ ++T+ +V +VT +G +++ VM L +LAAG+S+PD + S++VAREG GDMA+SN +GSNVFD+ LG+P+ IK + ++R +P+ + S
Sbjct: 61 CESYFIPSLEVISERLGLSQDVAGATFMAIGSSAPEFVTVFLGVFVTKGDIGVSTIVGSAVYNLLGICAACCLLSLSVSRLTCWPLFRDCVAYAISVAAVIAITFDNRIYWYESASLILIYGIYIVTMCFDIRINQYIMRRFSPCCTCCREAMVGNTEHEPLL-------------------GWKEDSLPVIRRHSRSDSGIFQEESDYSQLSISLSGL----KESSNNPPS----VFTMPEND--------------LKRIIWVLSLPIITLLYLTVPDCRRKRWKNLFILTFLMSAVWISAVTYILVWMVTVVGETLSIPDTVMGLTLLAAGTSIPDTVASVLVAREGKGDMAMSNIVGSNVFDM-LCLGVPWFIKTVFVDRSAPVEVNSS 411
BLAST of slc24a-4 vs. Ensembl Xenopus
Match: SLC24A5 (solute carrier family 24 member 5 [Source:NCBI gene;Acc:100490024]) HSP 1 Score: 207.994 bits (528), Expect = 3.979e-60 Identity = 135/393 (34.35%), Postives = 213/393 (54.20%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
C+ +F+PSLEV+SE+L LS DVAGATFMA GSS+PE + V + D+G+ TI GSAV+NLL I + +S SV +L P+ RDC Y IS+ +I D I WY++ ++LIY YI M F+ +I + R + CC + + + + L K SLP R I ++ SD + I L +PP + +P + LK II+V++ P + + T+ DC ++++K F+++F +S +W+ ++T+ +V +VT +G +++ VM L +LAAG+S+PD + S++VAREG GDMA+SN +GSNVFD+ LG+P+ IK + ++R +P+ + S
Sbjct: 72 CESYFIPSLEVISERLGLSQDVAGATFMAIGSSAPEFVTVFLGVFVTKGDIGVSTIVGSAVYNLLGICAACCLLSLSVSRLTCWPLFRDCVAYAISVAAVIAITFDNRIYWYESASLILIYGIYIVTMCFDIRINQYIMRRFSPCCTCCREAMVGNTEHEPLL-------------------GWKEDSLPVIRRHSRSDSGIFQEESDYSQLSISLSGL----KESSNNPPS----VFTMPEND--------------LKRIIWVLSLPIITLLYLTVPDCRRKRWKNLFILTFLMSAVWISAVTYILVWMVTVVGETLSIPDTVMGLTLLAAGTSIPDTVASVLVAREGKGDMAMSNIVGSNVFDM-LCLGVPWFIKTVFVDRSAPVEVNSS 422
BLAST of slc24a-4 vs. Ensembl Mouse
Match: Slc24a2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626]) HSP 1 Score: 223.787 bits (569), Expect = 1.093e-64 Identity = 144/431 (33.41%), Postives = 229/431 (53.13%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNR-----------------------NWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPA------FSRXXXXXXXXXXXXXXXXKPVIQCCN----LCNMCPPIRGSPP------KYSDYMVELPTTESHRFSRSNI-WFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y +Y+ FM FN ++ + + + D SK + NSL++ +I+ + AE R A + + E+ ++ + I+ N M P S P ++ + PT E ++ W K F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R SP+++ S
Sbjct: 154 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMISRNNVIKVTVPEAQAKSPTAGDKDGPTLPSKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCQVDENERQNGAANHVEKIELPNSTSTEVEMTPSSEASEPVQNGNLSHNIEAADAPTAEEEDDQPLSLSWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSS 584
BLAST of slc24a-4 vs. Ensembl Mouse
Match: Slc24a5 (solute carrier family 24, member 5 [Source:MGI Symbol;Acc:MGI:2677271]) HSP 1 Score: 204.912 bits (520), Expect = 6.607e-59 Identity = 131/403 (32.51%), Postives = 210/403 (52.11%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCC------YQSKVEPLK----EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQ 1592
CD +F+PSLE++S+ L LS DVAGATFMAAGSS+PEL ++ V + D+GI TI GSA++NLL I + +S V L P+ RDCA Y +S+G + + D I WY+ +LLIY Y+ + F+ I + + CC + ++E E++ +F+ + D + + S ++ +SL S+ + PP + +P + R I +V++ P + + + T DC ++ +K YF+++FF+S LW+ + T+ +V +VT G + + VM L +LAAG+S+PD + S++VAR+G GDMA+SN +GSNVFD+ LG+P+ IK N +PI + S+
Sbjct: 87 CDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCSPCCPCLARAMEERIEQQTLLGWEDESQLFIRRQSRTD--SGIFQEDSGYSQLSLSLHGLSQ-------------------------------VSEDPPS----VFSMPEADLRR--------------IFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDMLC-LGLPWFIKTAFTNASAPIEVNSK 437
BLAST of slc24a-4 vs. Ensembl Mouse
Match: Slc24a2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626]) HSP 1 Score: 138.658 bits (348), Expect = 2.965e-34 Identity = 68/136 (50.00%), Postives = 98/136 (72.06%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK 824
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y +Y+ FM FN ++ +
Sbjct: 154 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVER 289 HSP 2 Score: 113.62 bits (283), Expect = 4.961e-26 Identity = 55/138 (39.86%), Postives = 90/138 (65.22%), Query Frame = 3
Query: 1176 WFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
W K F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R SP+++ S
Sbjct: 468 WPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSS 605
BLAST of slc24a-4 vs. Ensembl Mouse
Match: Slc24a2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626]) HSP 1 Score: 138.658 bits (348), Expect = 3.014e-34 Identity = 68/136 (50.00%), Postives = 98/136 (72.06%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK 824
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y +Y+ FM FN ++ +
Sbjct: 154 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVER 289 HSP 2 Score: 114.39 bits (285), Expect = 3.018e-26 Identity = 59/168 (35.12%), Postives = 101/168 (60.12%), Query Frame = 3
Query: 1089 PIRGSPPKYSDYMVELPTTESHRFSRSNI-WFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
P++ ++ + PT E ++ W K F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R SP+++ S
Sbjct: 434 PVQNGNLSHNIEAADAPTAEEEDDQPLSLSWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSS 601
BLAST of slc24a-4 vs. Ensembl Mouse
Match: Slc24a2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626]) HSP 1 Score: 138.272 bits (347), Expect = 4.711e-34 Identity = 68/136 (50.00%), Postives = 98/136 (72.06%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK 824
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y +Y+ FM FN ++ +
Sbjct: 154 CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVER 289 HSP 2 Score: 114.005 bits (284), Expect = 3.763e-26 Identity = 55/138 (39.86%), Postives = 90/138 (65.22%), Query Frame = 3
Query: 1176 WFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
W K F++ FP + T+ D K +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +I+R SP+++ S
Sbjct: 513 WPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSS 650
BLAST of slc24a-4 vs. UniProt/SwissProt
Match: sp|Q8C261|NCKX5_MOUSE (Sodium/potassium/calcium exchanger 5 OS=Mus musculus OX=10090 GN=Slc24a5 PE=2 SV=1) HSP 1 Score: 204.912 bits (520), Expect = 4.622e-58 Identity = 131/403 (32.51%), Postives = 210/403 (52.11%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCC------YQSKVEPLK----EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQ 1592
CD +F+PSLE++S+ L LS DVAGATFMAAGSS+PEL ++ V + D+GI TI GSA++NLL I + +S V L P+ RDCA Y +S+G + + D I WY+ +LLIY Y+ + F+ I + + CC + ++E E++ +F+ + D + + S ++ +SL S+ + PP + +P + R I +V++ P + + + T DC ++ +K YF+++FF+S LW+ + T+ +V +VT G + + VM L +LAAG+S+PD + S++VAR+G GDMA+SN +GSNVFD+ LG+P+ IK N +PI + S+
Sbjct: 87 CDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCSPCCPCLARAMEERIEQQTLLGWEDESQLFIRRQSRTD--SGIFQEDSGYSQLSLSLHGLSQ-------------------------------VSEDPPS----VFSMPEADLRR--------------IFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDMLC-LGLPWFIKTAFTNASAPIEVNSK 437
BLAST of slc24a-4 vs. UniProt/SwissProt
Match: sp|Q71RS6|NCKX5_HUMAN (Sodium/potassium/calcium exchanger 5 OS=Homo sapiens OX=9606 GN=SLC24A5 PE=1 SV=1) HSP 1 Score: 203.371 bits (516), Expect = 1.597e-57 Identity = 134/402 (33.33%), Postives = 213/402 (52.99%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY-------QSKVEPLK--EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQ 1592
CD++F+PSLE++SE L LS DVAG TFMAAGSS+PEL ++ V + D+GI TI GSA++NLL I + +S +V L P+ RDCA Y IS ++ ++D + WY+ ++LLIY Y+ + F+ KI + + CC +S+ +PL E++ F+ + D + + S ++ +SL S+ + PP + +P + R I +V++ P + + T DC K+ +K YF+++FF+S +W+ + T+ +V +VT G + + VM L +LAAG+S+PD + S++VAR+G GDMA+SN +GSNVFD+ LGIP+ IK IN +P + S+
Sbjct: 87 CDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTD--SGIFYEDSGYSQLSISLHGLSQ-------------------------------VSEDPPS----VFNMPEADLKR--------------IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR 436
BLAST of slc24a-4 vs. UniProt/SwissProt
Match: sp|Q49SH1|NCKX5_DANRE (Sodium/potassium/calcium exchanger 5 OS=Danio rerio OX=7955 GN=slc24a5 PE=2 SV=1) HSP 1 Score: 199.134 bits (505), Expect = 6.999e-56 Identity = 124/400 (31.00%), Postives = 208/400 (52.00%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY--------QSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFS 1589
CD++F+PSLEV+SE+L LS DVAGATFMAAGSS+PEL ++ V + D+G+ TI GSAV+NLL I + +S +V +L P+ RDC Y IS+ +I + D + WYD +LL+Y Y+ + F+ +I + + + CC+ + +PL DD L + + + S + +SL + + SD + + H R + W++ + P + ++ DC + +K +++++F +S +W+ + T+ +V +VT +G + + VM + +LAAG+S+PD + S++VAREG DMA+SN +GSNVFD+ LG+P+ I+ + ++ GSP+ + S
Sbjct: 99 CDEYFLPSLEVISERLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIMGSAVYNLLCICAACGLLSSAVGRLSCWPLFRDCVAYAISVAAVIAIISDNRVYWYDGACLLLVYGVYVAVLCFDLRISEYVMQRFSPCCWCLKPRDRDSGEQQPLVGWSDDSSLRVQRRSRNDSGIFQDDSGYSHLSLSLHGLN--------------------------------------EISDEHKSVFSMPDHDLKR--------ILWVL---SLPVSTLLFVSVPDCRRPFWKNFYMLTFLMSAVWISAFTYVLVWMVTIVGETLGIPDTVMGMTLLAAGTSIPDTVASVMVAREGKSDMAMSNIVGSNVFDMLC-LGLPWFIQTVFVDVGSPVEVNS 448
BLAST of slc24a-4 vs. UniProt/SwissProt
Match: sp|Q9IAL7|NCKX2_CHICK (Sodium/potassium/calcium exchanger 2 OS=Gallus gallus OX=9031 GN=SLC24A2 PE=2 SV=1) HSP 1 Score: 143.28 bits (360), Expect = 4.853e-35 Identity = 79/181 (43.65%), Postives = 111/181 (61.33%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNWDKCCYQSKVE---PLKEEDDDIFLNSLIKYDRRNT 938
CD+FFVPSL V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++ +L Y Y+TFM FN + + K NRN + E P + DD L + + R +
Sbjct: 155 CDEFFVPSLTVITEKLSISDDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLILLIIFFLDNLIMWWESLTLLTAYFCYVTFMKFNVQVEEWVKKVLNRNKVEKATTGDAEGKSPTAGDKDDQTLTTKPRLQRGGS 335 HSP 2 Score: 104.375 bits (259), Expect = 3.847e-22 Identity = 50/132 (37.88%), Postives = 88/132 (66.67%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
K + +++ P + ++ D + +K+F ++FF SI W+ ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ +IN SP+++ S
Sbjct: 459 KQLTYLLVLPIVFPLWVSLPDVRNPRSRKFFPITFFGSISWIAFFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYAVINNFSPVTVSS 590
BLAST of slc24a-4 vs. UniProt/SwissProt
Match: sp|Q9U6A0|NCKX_DROME (Sodium/potassium/calcium exchanger Nckx30C OS=Drosophila melanogaster OX=7227 GN=Nckx30C PE=2 SV=4) HSP 1 Score: 143.28 bits (360), Expect = 1.023e-34 Identity = 78/159 (49.06%), Postives = 111/159 (69.81%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV--TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEED 890
CD+FFVPSL+V+ EKL ++ DVAGATFMAAG S+PELF+S+ V +F+ DVGIGTI GSAVFN+L +I + A SK+VL L W P+ RDC+FY IS+ LI+ D I W++A+++ IY Y+ FM +N ++ + C + K ++KV ++ D
Sbjct: 351 CDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFD-DVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQV-ETCVK---KMITKNKVTRVRSTD 504 HSP 2 Score: 100.523 bits (249), Expect = 7.004e-21 Identity = 56/156 (35.90%), Postives = 91/156 (58.33%), Query Frame = 3
Query: 1122 YMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
+ ++ P E S W K + +V+ P LV T+ D + K++F ++F SI+W+ + ++ MV G + VM L LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FD+ GL IP+++ +I G+P+ + S
Sbjct: 668 FSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGII-YGAPVEVNS 822
BLAST of slc24a-4 vs. TrEMBL
Match: A0A0H3YJA7 (Slc24a-4 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=slc24a-4 PE=2 SV=1) HSP 1 Score: 964.911 bits (2493), Expect = 0.000e+0 Identity = 508/514 (98.83%), Postives = 511/514 (99.42%), Query Frame = 3
Query: 60 MKRLKTNNRWNYAFHYKEHLFQYKLLVLISLTFWISIVCLVSLMVLSFPRNKSGITNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWXXXXXXXXXXXXXXXXXXCDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER 1601
MKR+KTNNRWNYAFHYKEHLFQYK LVLISLTFWISIVCLVSLMVLSFPRNK+G TNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWISLYILITLIIFIALAVICDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPL EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRSVSIIESIEEDVSD+IKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER
Sbjct: 1 MKRVKTNNRWNYAFHYKEHLFQYKPLVLISLTFWISIVCLVSLMVLSFPRNKTGFTNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWISLYILITLIIFIALAVICDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLNEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRSVSIIESIEEDVSDDIKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER 514
BLAST of slc24a-4 vs. TrEMBL
Match: A0A2R2MIW8 (sodium/potassium/calcium exchanger 3-like OS=Lingula unguis OX=7574 GN=LOC106158254 PE=3 SV=1) HSP 1 Score: 306.605 bits (784), Expect = 2.121e-93 Identity = 192/486 (39.51%), Postives = 288/486 (59.26%), Query Frame = 3
Query: 321 ENCDFEKSTNLTGVWXXXXXXXXXXXXXXXXXXCDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMK-RCNRNWDKCCYQSKVEPLKEE--------DDDIF--------------LNSLIKYDRRNTLINVISLP--------------------AEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVE--------LP--------TTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKE 1598
+C+ E L G+W++ Y + ++ F ALA++CDDFFVPSLE++SEKL LS DVAGATFMAAGSS+PELF+SI + T +DVG+GTI GSA+FN+L+II+LSAA++ VL LDWRP+ RD FY S+G I D + Y+ ++L +Y YI M FN ++M+ N+ C + + P E+ +DDI L+ + RR ++I+ S P A KR L S S ++ V P+ + + N P GSP + S +E LP ++E+ +W +ILKW++FV++FPF+V+F+++I DC+K KK+F SF +S++W+G L++AM+++V ++GC++ +++FVM LV +A G+S+PD + S++VAR+G GDMAVSNAIGSNVFDIN G+G+PF+IK++I G+P+ L E
Sbjct: 29 RHCELELQ-GLPGLWVAFYFFLIIVSFTALAIVCDDFFVPSLEIISEKLDLSEDVAGATFMAAGSSAPELFTSIVGLATDNNDVGVGTIAGSAMFNILIIIALSAALAGQVLYLDWRPLIRDSIFYATSVGVFIVFAWDGKLEHYETAILLFLYILYIVLMKFNIQVMEWMAGWNFCPCLCRPVIVPTVEDTAAGTQDSEDDIHNHKSATLQSGDLRKLSMAGGHARRLSIISGRSNPDTHHDKHFHHVHHGSLSGNFATKR--LSVVYSSSSHSTTVRPSVHHTEPPIPEADSEENGMKP--GSPNEGSIVEIEPEMYIFPCLPPLKMAPPDSSEAKEKGGCWLWSKFILKWVLFVISFPFVVLFTWSIPDCSKDHLKKWFWFSFLMSVVWIGLLSYAMIVVVERMGCILEIDTFVMGLVFIAIGTSVPDAMSSILVARDGYGDMAVSNAIGSNVFDINLGIGLPFLIKVIIQSGAPVYLVKPGE 509
BLAST of slc24a-4 vs. TrEMBL
Match: C1EE14 (Ca2+:Cation antiporter family (Fragment) OS=Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) OX=296587 GN=MICPUN_67917 PE=3 SV=1) HSP 1 Score: 234.187 bits (596), Expect = 1.830e-68 Identity = 136/379 (35.88%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFES---DVGIGTITGSAVFNLLVIISLSAAVS-KSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVI-SLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPF 1541
CDDFF PSLE++ EKL LS DVAGATFMAAGSS+PELF+S ++ ++ ++G+ TI GSAVFN+L+I++ + S ++ L LDWRP+TRDCAFY +SI +++ + D + W++ VV + +Y Y+ FM N M R + + RR TL N I S E R R ++ + +D V+ ++ F+ + W K+ ++ ++ P+ F+ T+ DC K +++++L+SFF S+LW+ ++++ MV +GC+++V VM +VLAAG+S+PD L S+ VA+ G GDMAV+NA+GSNVFDI GLG+P+
Sbjct: 21 CDDFFAPSLEIICEKLGLSEDVAGATFMAAGSSAPELFTSTMSLVSDNATNELGVATIVGSAVFNILIIVAATVIFSGETHLALDWRPVTRDCAFYAVSIAFVMGVMWDGKVYWWEGVVSVCLYLGYVGFMTINGSAMDWMER-------------------------VARGFRRRTLGNKIASFREETREETDDLER-----------------------SVVELSLSPEDDKAGGNDGTVDDEDEANNPFAVPDDW----RKYPMWALSLPWYAAFTVTVPDCGKTGWERWYLLSFFSSVLWISAISYGMVDAAAVVGCVLDVPEVVMGTLVLAAGTSVPDALSSVSVAQAGQGDMAVANAVGSNVFDIWLGLGLPW 347
BLAST of slc24a-4 vs. TrEMBL
Match: A0A401SV42 (Uncharacterized protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0012734 PE=3 SV=1) HSP 1 Score: 241.506 bits (615), Expect = 4.663e-68 Identity = 152/426 (35.68%), Postives = 239/426 (56.10%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRN------WDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKP--------VIQCCNLCNMCPPIRGSPPKYSDYMVE---LPT-----TESHRFSRSN---------IWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVPSL ++++KL++S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L+L W P+ RD +FY++ + LI I W+++V++L Y +Y+ FM FN + K+ RN +C + K + N+L++ +IN + AE + A + + + V D KP ++ N N+ + +PPK S V+ LP SR N W LK +I+++ P +++ T+ D K++ +KYF+++FF SI+W+G ++ MV ++G I ++ +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ IN +PI + S
Sbjct: 151 CDEFFVPSLTIITDKLQISDDVAGATFMAAGGSAPELFTSLIGVFISRSNVGIGTIVGSAVFNILFVIGMCALFSKQILRLTWWPLFRDVSFYIVDLILLILFFRSNTIVWWESVILLSAYGTYVVFMKFNVVLERWVKKKLTRNKVVEATATECDEKPKPRLQRGGSSASLHNTLMRNSIFQLMINTLDPLAEGKFHHRA--SILHKLAKNKCQVDDGEKPNVTTNHGDKVELPNTANV--EVEVTPPKDSPPAVQNGSLPNGAEVGAGQAEASRENEDEDQPLSLAWPDTPLKRLIYLIVIPIVLLLWITLPDVRKKRLRKYFILTFFGSIMWIGGFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLHAFINNFTPIKVSS 572
BLAST of slc24a-4 vs. TrEMBL
Match: R7QEG4 (Uncharacterized protein OS=Chondrus crispus OX=2769 GN=CHC_T00004583001 PE=3 SV=1) HSP 1 Score: 234.187 bits (596), Expect = 2.373e-66 Identity = 154/396 (38.89%), Postives = 215/396 (54.29%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWL---IFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDD-------IFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWF---LYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINR 1565
DD+FV +LE + E+L LS DVAGATFMAAGSS+PE F+S+ +V E +VGIGTI GSAVFN+LVII LSAA++ SVL LDWRP+ RD AFY++SI L + I WY+ ++++ Y Y+ FM F K + +N +S EP E+ D+ ++ S++ D T L + F VI + + S +E TE SR+ + ++ WI F + F + ++FS TIVDC+ ++ KY+ +F +SI+W+ +++ MV GCLI + + M L VLAAG+S+PD L S+ VAR G GDMAVSNAIGSNVFDI GLG P+ I L +
Sbjct: 102 TDDYFVAALERICERLDLSEDVAGATFMAAGSSTPEFFASMLSVFVTEDEVGIGTIVGSAVFNVLVIIGLSAALAGSVLSLDWRPLARDSAFYMMSIVLLLTFVLGSSRGEIKWYEGLILVFGYVLYVLFMAFGNKPYMKWAKNLKFG--KSAQEPDLEKGDNSPGDSEQVWTPSVVP-DPTPTKTRYSDLTPRSKFRAAQFG-------------------VIATIRMASHS----------SSQDLEDTATEEKSSSRAILGVDLPSSVVGWIFFPLTFFWRLLFSITIVDCSVEKKAKYWWATFILSIIWISVISYVMVEAARFSGCLIGIPASAMGLTVLAAGTSVPDALASISVARGGSGDMAVSNAIGSNVFDILLGLGFPWFIGGLAKK 465
BLAST of slc24a-4 vs. Ensembl Cavefish
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:103026719]) HSP 1 Score: 216.083 bits (549), Expect = 1.728e-62 Identity = 145/409 (35.45%), Postives = 224/409 (54.77%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNW--DKCCYQSKVEP-LKEEDDDIFL-NSLIKYDRRNTLINVISLPAEKRMSLPA--FSRXXXXXXXXXXXXXXXXKPVIQCCNL-CNMCPPIRGSPPK-----------YSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPI 1577
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D I++++++ +L YA Y+ FM +N + I NRN + K +P L+ L NSL++ +I+ + +E + A + +E+ K + N+ + PP+ G+ + + P T RF+ +L+IL + FP + T+ D K KK+F ++F +I W+ + ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ LIN PI
Sbjct: 125 CDEFFVPALTVITEKLAISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCAVFSKEILNLTWWPLFRDVSFYILGLIMLIVFFLDNYISYWESIALLTAYACYVIFMKYNGQVEMFIKGLINRNQVVEVVEAPPKAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLSEGKFREKASILHKIAKKKCQVEDANGVADKNLPNSSNVEVEVTPPLNGTAGQEGDTGEEDEEDDQPLSLSWPETCRKRFT-----YLFILP-----IVFPLWI----TLPDVRKPTSKKFFPITFLGAICWIAAFSYLMVWWAHQVGETIGITEEIMGLTMLAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLYSLINGLKPI 519
BLAST of slc24a-4 vs. Ensembl Cavefish
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:103026719]) HSP 1 Score: 213.386 bits (542), Expect = 2.273e-61 Identity = 145/427 (33.96%), Postives = 225/427 (52.69%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNW--DKCCYQSKVEPLKEEDDDI---------------FLNSLIKYDRRNTLINVISLPAEK-------RMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNL-CNMCPPIRGSPPK-----------YSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPI 1577
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D I++++++ +L YA Y+ FM +N + I NRN + KV P+ +D+ NSL++ +I+ + +E+ R + +E+ K + N+ + PP+ G+ + + P T RF+ +L+IL + FP + T+ D K KK+F ++F +I W+ + ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ LIN PI
Sbjct: 125 CDEFFVPALTVITEKLAISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCAVFSKEILNLTWWPLFRDVSFYILGLIMLIVFFLDNYISYWESIALLTAYACYVIFMKYNGQVEMFIKGLINRNQVVEVVEAPPKVSPVAVDDESKVSAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLSEEFADSGKFREKASILHKIAKKKCQVEDANGVADKNLPNSSNVEVEVTPPLNGTAGQEGDTGEEDEEDDQPLSLSWPETCRKRFT-----YLFILP-----IVFPLWI----TLPDVRKPTSKKFFPITFLGAICWIAAFSYLMVWWAHQVGETIGITEEIMGLTMLAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLYSLINGLKPI 537
BLAST of slc24a-4 vs. Ensembl Cavefish
Match: slc24a2 (sodium/potassium/calcium exchanger 2 [Source:NCBI gene;Acc:103028516]) HSP 1 Score: 213.386 bits (542), Expect = 2.454e-61 Identity = 139/413 (33.66%), Postives = 224/413 (54.24%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRC----NRNW-DKCCYQSKVEPLKEEDDDI--------------FLNSLIKYDRRNTLINVISLPAEKRMSLPA-FSRXXXXXXXXXXXXXXXXKPVIQCCNL-CNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQ 1592
CD+FFVP+L V++EKLK+S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D I + +++ +LL Y SY+ FM FNA + NRN D+ KV ++++ + NSL++ +I+ + E + A ++ + +E K + N+ + PP+ G+ + E + W K + ++ FP + T+ D +++ KK+F +F SI W+ + ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ + + P+++ S
Sbjct: 137 CDEFFVPALTVITEKLKISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIMDLIMLIVFFLDNYITYVESIALLLAYVSYVLFMKFNANVEGLVKGLMNRNQVDEIEVAPKVNNSVDDENKLSAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLNEGKFKEKASILHKIARKKGQDEANGVVDKNLPNSSNVEVEVTPPMNGNAGQEQAEEEEEGEDQPLSLG----WPDTNRKRLTYLFIFPIVFPLWLTLPDVRREKAKKFFPFTFLGSISWIAAFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLYAMFHNFKPVAVSSN 545
BLAST of slc24a-4 vs. Ensembl Cavefish
Match: slc24a2 (sodium/potassium/calcium exchanger 2 [Source:NCBI gene;Acc:103028516]) HSP 1 Score: 139.813 bits (351), Expect = 5.305e-35 Identity = 70/134 (52.24%), Postives = 96/134 (71.64%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI 818
CD+FFVP+L V++EKLK+S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D I + +++ +LL Y SY+ FM FNA +
Sbjct: 126 CDEFFVPALTVITEKLKISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIMDLIMLIVFFLDNYITYVESIALLLAYVSYVLFMKFNANV 259 HSP 2 Score: 103.219 bits (256), Expect = 7.850e-23 Identity = 49/133 (36.84%), Postives = 85/133 (63.91%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQ 1592
K + ++ FP + T+ D +++ KK+F +F SI W+ + ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ + + P+++ S
Sbjct: 402 KRLTYLFIFPIVFPLWLTLPDVRREKAKKFFPFTFLGSISWIAAFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLYAMFHNFKPVAVSSN 534
BLAST of slc24a-4 vs. Ensembl Cavefish
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:103026719]) HSP 1 Score: 138.272 bits (347), Expect = 2.239e-34 Identity = 75/165 (45.45%), Postives = 107/165 (64.85%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNW--DKCCYQSKVEPLKEEDD 893
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D I++++++ +L YA Y+ FM +N + I NRN + KV P+ +D+
Sbjct: 125 CDEFFVPALTVITEKLAISDDVAGATFMAAGGSAPELFTSVIGVFISHSNVGIGTIVGSAVFNILFVIGMCAVFSKEILNLTWWPLFRDVSFYILGLIMLIVFFLDNYISYWESIALLTAYACYVIFMKYNGQVEMFIKGLINRNQVVEVVEAPPKVSPVAVDDE 289 HSP 2 Score: 102.449 bits (254), Expect = 1.400e-22 Identity = 58/147 (39.46%), Postives = 89/147 (60.54%), Query Frame = 3
Query: 1137 PTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPI 1577
P T RF+ +L+IL + FP + T+ D K KK+F ++F +I W+ + ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ LIN PI
Sbjct: 417 PETCRKRFT-----YLFILP-----IVFPLWI----TLPDVRKPTSKKFFPITFLGAICWIAAFSYLMVWWAHQVGETIGITEEIMGLTMLAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLYSLINGLKPI 549
BLAST of slc24a-4 vs. Ensembl Sea Lamprey
Match: slc24a1 (solute carrier family 24 member 1 [Source:ZFIN;Acc:ZDB-GENE-060503-191]) HSP 1 Score: 143.665 bits (361), Expect = 3.385e-37 Identity = 70/134 (52.24%), Postives = 98/134 (73.13%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI 818
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A S+ +L L W P+ RD +FY++ + LI D +I W++++++L Y SY+ FM FNAK+
Sbjct: 52 CDEFFVPALGVITEKLAISDDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGMCAVFSREILVLTWWPLFRDVSFYIVGLSMLIIFFLDNLIQWWESMLLLSCYVSYVVFMKFNAKV 185 HSP 2 Score: 103.605 bits (257), Expect = 1.179e-23 Identity = 48/115 (41.74%), Postives = 80/115 (69.57%), Query Frame = 3
Query: 1245 TIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
T+ D + +K+F+++FF SILW+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL +P+++ L+ +P+ + S
Sbjct: 379 TLPDVRNHRSRKFFMVTFFGSILWIAIFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPMPWLMFSLVKGFAPVQVSS 493
BLAST of slc24a-4 vs. Ensembl Sea Lamprey
Match: slc24a4b (solute carrier family 24 member 4b [Source:ZFIN;Acc:ZDB-GENE-081031-75]) HSP 1 Score: 137.117 bits (344), Expect = 5.585e-35 Identity = 73/151 (48.34%), Postives = 99/151 (65.56%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSI-----AAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMV--FNAKIMKRCNRNWDKC 851
CDDFFVPSLE +SE+L+LS DVAGATFMAAGSS+PELF+S+ + DVG+GTI GSAVFN+L II + + +++L W + RD FY ISI LI + D I++W+++V+++++YA YI M FN KI C
Sbjct: 42 CDDFFVPSLEKISERLQLSEDVAGATFMAAGSSAPELFTSVIVWCEGVFVTKGDVGVGTIVGSAVFNILCIIGVCGLFAGQIVRLTWWSLFRDSVFYTISIIALILFICDEIVSWWESVILIMLYALYILVMKQRFNMKIQTFLGSKRKPC 192 HSP 2 Score: 116.316 bits (290), Expect = 6.863e-28 Identity = 57/135 (42.22%), Postives = 94/135 (69.63%), Query Frame = 3
Query: 1191 LKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
LKW+ A+P ++ +T+ +C K +++ +F+ SF +S +W+ ++ MV +VT IG + + +M + LAAG+S+PD + SLIVAR+G GDMAVSN+IGSNVFDI GLG+P+ ++ +L++ GS + + S+
Sbjct: 351 LKWMF---AWPLGLLLYFTVPNCAKARWENWFMASFVISTIWIAVFSYVMVWMVTVIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILVGLGLPWALQTLLVDYGSHVEINSR 482
BLAST of slc24a-4 vs. Ensembl Sea Lamprey
Match: SLC8B1 (solute carrier family 8 member B1 [Source:HGNC Symbol;Acc:HGNC:26175]) HSP 1 Score: 56.6102 bits (135), Expect = 5.596e-9 Identity = 28/86 (32.56%), Postives = 52/86 (60.47%), Query Frame = 3
Query: 1278 KYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGI 1535
+ ++ F VS LW+ ++ +V ++ G + ++S V+ L +LA G+S+PD + + +AR+G MA+S G VF+I G+G+
Sbjct: 201 AFAVLGFVVSALWMNAIANEVVNLLQTFGVVFGISSTVLGLTLLAWGNSVPDFVADITMARQGYPRMAISACFGGIVFNILVGIGL 286
BLAST of slc24a-4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006683.1 (pep scaffold:Pmarinus_7.0:GL476710:281470:285756:-1 gene:ENSPMAG00000006040.1 transcript:ENSPMAT00000006683.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 48.521 bits (114), Expect = 1.644e-6 Identity = 28/85 (32.94%), Postives = 47/85 (55.29%), Query Frame = 3
Query: 1296 FFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVA-REGCGDMAVSNAIGSNVFDINTGLGIPFMI 1547
F VSI +G LT + + + GC + + V ++V +A G+S+PD S + A ++ D +V N GSN ++ G+GI + I
Sbjct: 126 FLVSISVIGLLTAMIGDLASHFGCTVGLKDSVTAVVFVALGTSIPDTFASKVAAVQDQFADASVGNVTGSNAVNVFLGIGIAWTI 210
BLAST of slc24a-4 vs. Ensembl Nematostella
Match: EDO32048 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW69]) HSP 1 Score: 199.519 bits (506), Expect = 1.284e-57 Identity = 134/392 (34.18%), Postives = 208/392 (53.06%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKRCNRN---------WDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCC--NLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK 1550
CDD+FVP LE++ ++L L DVAGATFMA GSS+PELF+S+ V + D+G+GTI GSAVFN+L +I + + +VL L W P+ RD FYL S+ L+ + D ++ W +A M+ Y+ Y+ M FN +I + R + ++ ++K +P+++ D+++ L D N + R+ F++ P+I +L + + P D + P + N+W I +V+ P + F TI D K +K+ ++SF + I+W+G ++ +V +VT IG + VM L ++A GSS+PD L SL VAR+G GDMAVS+ +GSNVFDI LGIP++IK
Sbjct: 43 CDDYFVPCLEIICDRLGLQTDVAGATFMALGSSAPELFASVIGVFITKGDIGVGTILGSAVFNVLFVIGVCGVGAGTVLYLAWWPMVRDSVFYLFSLVGLMLVLMDNVVVWSEATAMVSFYSVYLLIMYFNPRIEAYLYRVTKTTTPEYKSDLHEQKATKTKYDPVQQTDNEVEAEIL---DNVNGSDDTTKKGLLGRIYELYFNK------------EKVKSPLIVGFGEHLAHHHEYEQHVPHDVPDLTLGSPFSPPE-----NVW-----PRICWVLGLPINLSFFLTIPDVKKPSCEKWVVLSFIICIVWIGVTSYVLVWMVTVIGYTFLIPDSVMGLSLVAFGSSVPDCLSSLFVARKGDGDMAVSHTVGSNVFDILLCLGIPWLIK 409
BLAST of slc24a-4 vs. Ensembl Nematostella
Match: EDO35212 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM57]) HSP 1 Score: 174.866 bits (442), Expect = 3.579e-48 Identity = 83/181 (45.86%), Postives = 126/181 (69.61%), Query Frame = 3
Query: 1068 NLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKERVSL 1610
+C PP+ P+Y PT E +S + Y++ W++FV++FPF+ ++++TI DC+K +K+FL SF +SI+W+ L+F +V +V + GC++NV+ F M LV++A G+S+PD L S+IVAR+G GDMAVSNAIGSNVFDIN GLG+PF+I+ILI++ PI + + E + L
Sbjct: 296 KVCPCLPPVSIETPEY-------PTEERTCWSSTK----YVMGWVLFVLSFPFVCLYTWTIPDCSKPHNRKWFLASFTMSIVWIAILSFGLVTVVGRSGCILNVDKFTMGLVIIAIGTSVPDALSSIIVARDGFGDMAVSNAIGSNVFDINLGLGLPFVIRILIDKMEPIRMLTPAEEIML 465 HSP 2 Score: 169.859 bits (429), Expect = 2.285e-46 Identity = 85/134 (63.43%), Postives = 103/134 (76.87%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIM 821
CDDFFVPSLE +SEKL LS DVAGATFMAAGSS+PELF+SIA VT +SDVG+GTI GSA+FNLLVII+L+AA S VL+LDWRP+ RD Y +SI + I D Y+A V+L++Y +YI M FN K+M
Sbjct: 21 CDDFFVPSLEAISEKLDLSEDVAGATFMAAGSSAPELFTSIAGVTVDSDVGVGTIVGSAIFNLLVIIALTAAFSGQVLQLDWRPLLRDSVAYSLSIAFFIIFSWDGKFEMYEAAVLLILYIAYIVVMKFNPKLM 154
BLAST of slc24a-4 vs. Ensembl Nematostella
Match: EDO41421 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I7]) HSP 1 Score: 139.043 bits (349), Expect = 5.229e-35 Identity = 72/139 (51.80%), Postives = 100/139 (71.94%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAA--VTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLIS-IGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKR 827
CD+FFVPSL V+ EKL+L DVAGATFMAAG S+PELF+S + +S+VGIGTI GSAVFN+L +I + A SK VL+L W P+ RDC FY ++ I +IF + +I W++++V+LL Y +Y+ FM +N + +R
Sbjct: 126 CDEFFVPSLTVIIEKLELKEDVAGATFMAAGGSAPELFTSFIGTFIDPKSNVGIGTIVGSAVFNVLFVIGMCAMFSKGVLELTWWPLFRDCIFYSLALIILIIFFLSGDVIVWWESLVLLLCYFAYVIFMKYNHNVERR 264 HSP 2 Score: 103.219 bits (256), Expect = 3.134e-23 Identity = 51/141 (36.17%), Postives = 91/141 (64.54%), Query Frame = 3
Query: 1200 IIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKERVSLINFY 1622
+ +V+ P + + YT+VD + + + + ++F +SI W+ ++ MV T++G ++ + VM L LAAG+S+PDL+ S++VAR+G GDMAVS++IGSN+FDI GL +P++ +N G +++ S+ S+I +
Sbjct: 459 VFYVIKAPLMFLMYYTMVDVRRPERRHLYPITFLMSIFWIAFFSYFMVWWATEVGYTFDIPTEVMGLTFLAAGTSVPDLITSVLVARKGFGDMAVSSSIGSNLFDITVGLPLPWLCYSAVNLGLAVNVSSRGILYSVIMLF 599
BLAST of slc24a-4 vs. Ensembl Nematostella
Match: EDO48007 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKL4]) HSP 1 Score: 125.176 bits (313), Expect = 3.155e-31 Identity = 65/138 (47.10%), Postives = 91/138 (65.94%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRC 830
C+DFFV SL +S L L PDVAGATFMA GSS+P LF +I ++ F E D+G+GTI GS +FN L II+L A S L+L PI+RD Y+ S+ L+ S++D + WY+ ++ +++YA YI M FN ++ C
Sbjct: 42 CEDFFVASLNRISMCLGLKPDVAGATFMAVGSSAPTLFIAIISIFFTEGDIGLGTIVGSTIFNTLFIIALCAIGSGVTLQLACYPISRDSTVYVASVIVLMVSIYDNKVYWYEGLIFVIVYAIYIVIMYFNDQVEGLC 179 HSP 2 Score: 107.457 bits (267), Expect = 3.516e-25 Identity = 57/131 (43.51%), Postives = 90/131 (68.70%), Query Frame = 3
Query: 1203 IFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
++V P +++F TI DC K+ ++K++L++F V+++W+ L++ +V +V IG + VM + LAAGSSLPD + SL+VA++G GDMAVSN IGSNVFD+ LGIP++IK + G P+ + S+
Sbjct: 239 LWVFTLPSILVFYVTIPDCRKKTWRKFYLVTFTVAVIWMAVLSYFLVWMVAIIGYTYTIPECVMGMTFLAAGSSLPDAIASLVVAKQGSGDMAVSNCIGSNVFDMLC-LGIPWLIKSAFLQPGKPVVIQSE 368
BLAST of slc24a-4 vs. Ensembl Nematostella
Match: EDO48006 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKL3]) HSP 1 Score: 125.946 bits (315), Expect = 1.171e-30 Identity = 64/159 (40.25%), Postives = 102/159 (64.15%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDD 893
CD++F SLE + ++L++ DVAGATFMAAGSS P LF +IA+V E D+G+GTI GS++FN+L I ++ S V+ L PI RD Y++++ L+ +HD +I++Y+A++ ++Y YI MVFN ++ ++ CC +K + E +D
Sbjct: 68 CDNYFCASLEKLCKRLRIPTDVAGATFMAAGSSMPTLFIAIASVFMGEGDIGLGTIIGSSMFNILFITAICGLFSGMVISLHTWPIVRDSCVYVVNLVGLLIVIHDNVIHFYEALIFPVLYTGYILIMVFNTRLENAFESAFETCCDINKGMEMVEMED 226 HSP 2 Score: 98.9821 bits (245), Expect = 8.301e-22 Identity = 46/118 (38.98%), Postives = 83/118 (70.34%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMI 1547
K I+++ P + F T+ DC ++++ ++ +F +SI+W+ +L++ +V V+ IG ++ ++M L +LAAGSS+PD++ SLIVA+ G GDMA++N IGSN+FD+ LG+P+++
Sbjct: 419 KRIVWIFMLPVHLAFYVTMPDCRVKKWEAWYPATFALSIIWMAALSYVLVWTVSIIGETFSIPEYIMGLTLLAAGSSVPDVMSSLIVAKHGMGDMALANCIGSNIFDV-LCLGLPWLL 535
BLAST of slc24a-4 vs. Ensembl Medaka
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:101167489]) HSP 1 Score: 207.608 bits (527), Expect = 3.977e-59 Identity = 150/437 (34.32%), Postives = 227/437 (51.95%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKRC-NRNWDKCCYQSKVEPLKEED--DDIFL------------------NSLIKYDRRNTLINVISLPAEKRMSLPA----------------------FSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+SI V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D II +++V +L YA+Y+ FM FN+K+ +K C +RN + +V+P +++ D + L NSL++ +I+ + +E + A SR+ + I +P+ C N + + D + L ES+R F Y+L I + P + T+ D K KK+F ++F SI W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P++ N P+ + S
Sbjct: 127 CDEFFVPALTVITEKLNISDDVAGATFMAAGGSAPELFTSIIGVFISHSNVGIGTIVGSAVFNILFVIGMCAIFSKEILNLTWWPLFRDVSFYILDLIMLIIFFLDNIILVWESVTLLSAYAAYVIFMKFNSKMEGFVKSCMHRN---QVVEVEVQPKVKDNLTDTLTLPFQARPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLSEGKFREKASILHKIAKKKCQVEDSEKANGVSSRAGKMTSKISTSKDRVTQPLRTECTDENWS-YVNAEDEEEEDQPLSLSWPESNRKR-----FTYLL---IMPIVLPLWI----TLPDVRKTSSKKFFPVTFLGSITWIAVFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLFWSFFNGLKPVQVSS 547
BLAST of slc24a-4 vs. Ensembl Medaka
Match: slc24a5 (solute carrier family 24 member 5 [Source:NCBI gene;Acc:101173921]) HSP 1 Score: 197.978 bits (502), Expect = 1.086e-56 Identity = 130/401 (32.42%), Postives = 213/401 (53.12%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCY--------QSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIK-ILINRGSPISLFSQ 1592
CDD+F+PSLEV+SE+L LS DVAGATFMAAGSS+PEL ++ V + D+G+ TI GSAV+NLL I + ++ +L P+ RDC Y IS+ +I + D + WY+A +LL+Y YI + F+ +I + R CC + + +PL +DD L + + + + S + +SL + I + K + +P ++ R L++L + V+ F T+ DC ++ +K++F+++FF+S +W+ + T+ +V +VT +G + + VM L +LAAG+S+PD + S++VAREG DMA+SN +GSNVFD+ LG+P+ IK + ++ +P+ + S
Sbjct: 56 CDDYFLPSLEVISERLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIVGSAVYNLLGICAACGILASVARRLTCWPLFRDCLAYGISVAAVIGIISDNKVYWYEAACLLLVYGVYIVVLCFDLRISEFVLRKLSPCCTCLSSGSADKMETQPLTGWNDDTRLRICGRSRTDSGIFHDDSGYSHLSLSLHGLNE-------------------------------ISDAEQK---SVFSVPESDLKR-------ILWVLSLPVIVLLF-------LTVPDCRRRFWKQWFMITFFMSAVWISAFTYVLVWMVTVVGETLGIPDTVMGLTLLAAGTSIPDTVASVMVAREGKADMAMSNIVGSNVFDMLC-LGLPWFIKTVFVDTINPVEVNSS 407
BLAST of slc24a-4 vs. Ensembl Medaka
Match: slc24a2 (sodium/potassium/calcium exchanger 2-like [Source:NCBI gene;Acc:101165788]) HSP 1 Score: 184.882 bits (468), Expect = 9.759e-51 Identity = 135/413 (32.69%), Postives = 212/413 (51.33%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAV-TFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINW---------YDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEP-----LKEEDDDIFL-NSLIKYDRRNTLINVISLPAEKRMS--LPAF-------------SRXXXXXXXXXXXXXXXXKPVIQCCNLC-NMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILIN 1562
CD+FFVP+L V++EKL++S DVAGATFMAAG S+PELF+S+ V S+VGIGTI GSAVFN+L +I + A SK VL L W P+ RD +FY+I + LI+ D I Y V + Y + + F + +K+ + S V P L+ E L NSL++ +I+ + +++ ++ L F + + ++ K N+ + PP+ G D E E S + W K + +++ FP + T+ D ++ +++F +F SI W+ ++ MV ++G + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P+++ +IN
Sbjct: 154 CDEFFVPALTVITEKLEISDDVAGATFMAAGGSAPELFTSVIGVFVSHSNVGIGTIVGSAVFNILFVIGMCALFSKEVLNLTWWPLFRDVSFYIIGLLMLIYFFLDNQITMSESISLLLCYSCYVTFMKYNAKVEFFI-KSKLGSNQVDELEASPRVSLVPPSARPRLQREGSCASLHNSLMRNSIFQLMIHTLDPLSDEGVAHKLSVFVTAGGFKEKASILHKMAKKKCKDDGVTANVEKNTSNSSNVAVEVTPPMNGV--AGGDQAGEEDDDEGQPLSLA--WPDTFRKRLTYLIIFPIIFPLWLTLPDVRRENAERFFPFTFLGSICWIAFFSYLMVWWAHQVGETFWITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLFNIIN 561
BLAST of slc24a-4 vs. Ensembl Medaka
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:101167489]) HSP 1 Score: 144.05 bits (362), Expect = 2.195e-36 Identity = 82/164 (50.00%), Postives = 110/164 (67.07%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKRC-NRNW-DKCCYQSKVEPLKEEDD 893
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+SI V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D II +++V +L YA+Y+ FM FN+K+ +K C +RN + Q K P EDD
Sbjct: 148 CDEFFVPALTVITEKLNISDDVAGATFMAAGGSAPELFTSIIGVFISHSNVGIGTIVGSAVFNILFVIGMCAIFSKEILNLTWWPLFRDVSFYILDLIMLIIFFLDNIILVWESVTLLSAYAAYVIFMKFNSKMEGFVKSCMHRNQVVEVEVQPKASPGAPEDD 311 HSP 2 Score: 98.5969 bits (244), Expect = 2.457e-21 Identity = 50/132 (37.88%), Postives = 80/132 (60.61%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
K +++ P ++ T+ D K KK+F ++F SI W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P++ N P+ + S
Sbjct: 433 KRFTYLLIMPIVLPLWITLPDVRKTSSKKFFPVTFLGSITWIAVFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLFWSFFNGLKPVQVSS 564
BLAST of slc24a-4 vs. Ensembl Medaka
Match: SLC24A2 (solute carrier family 24 member 2 [Source:NCBI gene;Acc:101167489]) HSP 1 Score: 144.05 bits (362), Expect = 3.138e-36 Identity = 82/164 (50.00%), Postives = 110/164 (67.07%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKI---MKRC-NRNW-DKCCYQSKVEPLKEEDD 893
CD+FFVP+L V++EKL +S DVAGATFMAAG S+PELF+SI V S+VGIGTI GSAVFN+L +I + A SK +L L W P+ RD +FY++ + LI D II +++V +L YA+Y+ FM FN+K+ +K C +RN + Q K P EDD
Sbjct: 148 CDEFFVPALTVITEKLNISDDVAGATFMAAGGSAPELFTSIIGVFISHSNVGIGTIVGSAVFNILFVIGMCAIFSKEILNLTWWPLFRDVSFYILDLIMLIIFFLDNIILVWESVTLLSAYAAYVIFMKFNSKMEGFVKSCMHRNQVVEVEVQPKASPGAPEDD 311 HSP 2 Score: 98.5969 bits (244), Expect = 2.381e-21 Identity = 50/132 (37.88%), Postives = 80/132 (60.61%), Query Frame = 3
Query: 1194 KWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFS 1589
K +++ P ++ T+ D K KK+F ++F SI W+ ++ MV ++G I + +M L +LAAG+S+PDL+ S+IVAR+G GDMAVS+++GSN+FDI GL P++ N P+ + S
Sbjct: 455 KRFTYLLIMPIVLPLWITLPDVRKTSSKKFFPVTFLGSITWIAVFSYLMVWWAHQVGETIGITEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLFWSFFNGLKPVQVSS 586
BLAST of slc24a-4 vs. Planmine SMEST
Match: SMESG000036251.1 (SMESG000036251.1) HSP 1 Score: 880.552 bits (2274), Expect = 0.000e+0 Identity = 468/472 (99.15%), Postives = 470/472 (99.58%), Query Frame = 3
Query: 186 LMVLSFPRNKSGITNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWXXXXXXXXXXXXXXXXXXCDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER 1601
LMVLSFPRNK+G TNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWISLYILITLIIFIALAVICDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPL EEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRSVSIIESIEEDVSD+IKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER
Sbjct: 16 LMVLSFPRNKTGFTNRNLLQSVQNVYYYSNCTNTTTIPNILQVFWENCDFEKSTNLTGVWISLYILITLIIFIALAVICDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTFESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLNEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRSVSIIESIEEDVSDDIKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQKER 487
BLAST of slc24a-4 vs. Planmine SMEST
Match: SMESG000010390.1 (SMESG000010390.1) HSP 1 Score: 218.394 bits (555), Expect = 3.935e-64 Identity = 139/397 (35.01%), Postives = 212/397 (53.40%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNT-----LINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQ 1592
C+D+FVP LE + E LKL PDVAGATFMAAGSS+PEL ++I V + D+ +G + GSA +NL+ +I LSA +K+V++L+W P+ RDCAFY ISI L ++D ++ WY+A+V + Y YI FN + K + D+ +++ + D T +IN + E S D+ K C MC +R +ELP + R W+ Y + + +P +I DC ++ ++K+F ++F S +W+G ++ M+ ++T IG + + VM L +AAGSS+PD + S++V REG GDMAVSNA+GSNVFDI +G+P++IK L G PI ++S+
Sbjct: 78 CEDYFVPCLECICENLKLQPDVAGATFMAAGSSAPELATTIIGVFIAKDDIALGAVVGSADYNLMFVIGLSALFAKTVIQLNWWPLFRDCAFYSISIILLALVIYDNLVYWYEAIVFIFFYGIYIVLNYFNKSLELWAKMLVTKYLPNCTINNENLSDEAFLMSNEVAEDLHTTSTGIEMINSGTESDEDYESGKLIGTRNRNGSCCSSDIDFAKK------TGCAMC--LRSCFAT-----LELPDKKKAR------WWNYFY----YGLCYPLRFFLCVSIPDCRERFFRKWFWITFINSCIWIGMYSYIMIWMITVIGFTLGIPDSVMGLTFIAAGSSVPDAIASVLVVREGQGDMAVSNAVGSNVFDILICMGVPWLIKCL-TLGKPILIYSK 450
BLAST of slc24a-4 vs. Planmine SMEST
Match: SMESG000010390.1 (SMESG000010390.1) HSP 1 Score: 217.238 bits (552), Expect = 8.979e-64 Identity = 132/392 (33.67%), Postives = 209/392 (53.32%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAKIMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQYKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKILINRGSPISLFSQ 1592
C+D+FVP LE + E LKL PDVAGATFMAAGSS+PEL ++I V + D+ +G + GSA +NL+ +I LSA +K+V++L+W P+ RDCAFY ISI L ++D ++ WY+A+V + Y YI FN + K + D+ +++ + D T + + + +R+ + + + C C +ELP + R W+ Y + + +P +I DC ++ ++K+F ++F S +W+G ++ M+ ++T IG + + VM L +AAGSS+PD + S++V REG GDMAVSNA+GSNVFDI +G+P++IK L G PI ++S+
Sbjct: 78 CEDYFVPCLECICENLKLQPDVAGATFMAAGSSAPELATTIIGVFIAKDDIALGAVVGSADYNLMFVIGLSALFAKTVIQLNWWPLFRDCAFYSISIILLALVIYDNLVYWYEAIVFIFFYGIYIVLNYFNKSLELWAKMLVTKYLPNCTINNENLSDEAFLMSNEVAEDLHTTSTGIEMINSGTESG----TRNRNGSCCSSDIDFAKKTGCAMCLRSCFA--------------TLELPDKKKAR------WWNYFY----YGLCYPLRFFLCVSIPDCRERFFRKWFWITFINSCIWIGMYSYIMIWMITVIGFTLGIPDSVMGLTFIAAGSSVPDAIASVLVVREGQGDMAVSNAVGSNVFDILICMGVPWLIKCL-TLGKPILIYSK 440
BLAST of slc24a-4 vs. Planmine SMEST
Match: SMESG000030115.1 (SMESG000030115.1) HSP 1 Score: 194.897 bits (494), Expect = 9.130e-56 Identity = 137/399 (34.34%), Postives = 207/399 (51.88%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQ-YKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQK 1595
CD++FV SLE + E + DVAGATFMAAGSS+PEL +S+ V +SDVGI TI GSAVFN+L II++ SV+ L+W P+ RDC Y +SI LI ++D +I WY+A+VML +Y +YI + +N +++R R Y + PL ++ L + + R+ L ++ N+ G P + E+P + HR L W V P + +TI DC K ++K FL++FF+S++W+ T+ +V ++ IG +++ +M L LAAG+S+PD + +VA++G GDMA+SN+IGSNVFDI LG+P+ I+ +N GS I + S
Sbjct: 93 CDEYFVSSLERLCEVFNIKHDVAGATFMAAGSSAPELCTSVIGVFITKSDVGISTIVGSAVFNVLCIIAICGIFVGSVIHLNWWPMFRDCIIYCLSIIALIIILNDGLIQWYEALVMLFMYVAYIIILYYNGNLYGFVIQRLPRLKG---YGEEHNPLISQNLPTSFGLLDSSEEEEIMETGDVDSIHSRIRLDE--------------------------DMTNL----EGESPT----IFEVPNSFCHR-----------LYW---VAMLPVAAICYFTIPDCRKPGIWRKLFLVTFFISVIWISVATYILVWMICLIGDTLDIPDTIMGLTFLAAGTSIPDAIAGYLVAKDGYGDMAISNSIGSNVFDILICLGLPWFIRTSFLNPGSEIPVESSS 440
BLAST of slc24a-4 vs. Planmine SMEST
Match: SMESG000030115.1 (SMESG000030115.1) HSP 1 Score: 194.897 bits (494), Expect = 1.375e-55 Identity = 137/399 (34.34%), Postives = 207/399 (51.88%), Query Frame = 3
Query: 420 CDDFFVPSLEVMSEKLKLSPDVAGATFMAAGSSSPELFSSIAAVTF-ESDVGIGTITGSAVFNLLVIISLSAAVSKSVLKLDWRPITRDCAFYLISIGWLIFSVHDTIINWYDAVVMLLIYASYITFMVFNAK----IMKRCNRNWDKCCYQSKVEPLKEEDDDIFLNSLIKYDRRNTLINVISLPAEKRMSLPAFSRXXXXXXXXXXXXXXXXKPVIQCCNLCNMCPPIRGSPPKYSDYMVELPTTESHRFSRSNIWFLYILKWIIFVVAFPFLVMFSYTIVDCTKQQ-YKKYFLMSFFVSILWLGSLTFAMVIIVTKIGCLINVNSFVMSLVVLAAGSSLPDLLGSLIVAREGCGDMAVSNAIGSNVFDINTGLGIPFMIKI-LINRGSPISLFSQK 1595
CD++FV SLE + E + DVAGATFMAAGSS+PEL +S+ V +SDVGI TI GSAVFN+L II++ SV+ L+W P+ RDC Y +SI LI ++D +I WY+A+VML +Y +YI + +N +++R R Y + PL ++ L + + R+ L ++ N+ G P + E+P + HR L W V P + +TI DC K ++K FL++FF+S++W+ T+ +V ++ IG +++ +M L LAAG+S+PD + +VA++G GDMA+SN+IGSNVFDI LG+P+ I+ +N GS I + S
Sbjct: 71 CDEYFVSSLERLCEVFNIKHDVAGATFMAAGSSAPELCTSVIGVFITKSDVGISTIVGSAVFNVLCIIAICGIFVGSVIHLNWWPMFRDCIIYCLSIIALIIILNDGLIQWYEALVMLFMYVAYIIILYYNGNLYGFVIQRLPRLKG---YGEEHNPLISQNLPTSFGLLDSSEEEEIMETGDVDSIHSRIRLDE--------------------------DMTNL----EGESPT----IFEVPNSFCHR-----------LYW---VAMLPVAAICYFTIPDCRKPGIWRKLFLVTFFISVIWISVATYILVWMICLIGDTLDIPDTIMGLTFLAAGTSIPDAIAGYLVAKDGYGDMAISNSIGSNVFDILICLGLPWFIRTSFLNPGSEIPVESSS 418 The following BLAST results are available for this feature:
BLAST of slc24a-4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of slc24a-4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of slc24a-4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 4
BLAST of slc24a-4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of slc24a-4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of slc24a-4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of slc24a-4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30006161 ID=SMED30006161|Name=slc24a-4|organism=Schmidtea mediterranea sexual|type=transcript|length=1655bpback to top protein sequence of SMED30006161-orf-1 >SMED30006161-orf-1 ID=SMED30006161-orf-1|Name=SMED30006161-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=525bp MKRLKTNNRWNYAFHYKEHLFQYKLLVLISLTFWISIVCLVSLMVLSFPRback to top protein sequence of SMED30006161-orf-2 >SMED30006161-orf-2 ID=SMED30006161-orf-2|Name=SMED30006161-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=136bp MGLQSSLRTDLDTAADKEIITNKLKTADPVIVPMPTSDSNVTAAIDENSSback to top Aliases
The feature 'slc24a-4' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
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