NAD-dependent protein deacetylase

Overview


Name	NAD-dependent protein deacetylase
Smed ID	SMED30005908
Length (bp)	1647

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of NAD-dependent protein deacetylase (SMED30005908) t-SNE clustered cells

Violin plots show distribution of expression levels for NAD-dependent protein deacetylase (SMED30005908) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NAD-dependent protein deacetylase (SMED30005908) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NAD-dependent protein deacetylase (SMED30005908) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30005908

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30005908	SMESG000079803.1	dd_Smed_v6_10955_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
testis	SMED30005908	SMESG000079803.1 SMESG000019442.1 SMESG000037000.1	Contig5397	newmark_ests	PMID:28434803 Rouhana et al., 2017
testis	SMED30005908	SMESG000079803.1 SMESG000019442.1 SMESG000037000.1	Contig5397	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
testis	SMED30005908	SMESG000019746.1	Contig5397	newmark_ests	PMID:28434803 Rouhana et al., 2017
testis	SMED30005908	SMESG000019746.1	Contig5397	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
epidermis	SMED30005908	SMESG000079803.1	dd_Smed_v4_10955_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
Match: SIRT3 (sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931])

HSP 1 Score: 299.286 bits (765), Expect = 3.501e-97
Identity = 147/285 (51.58%), Postives = 188/285 (65.96%), Query Frame = 1

Query:  427 PFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            PF   G  L    G DD     D+ + I     + +V+M GAGIS PSGIPDFRSPG+GLY NL+QY +PYPEAIF++ +F  NPKPFF LAKEL+P G Y+PN  HYF RLL +K LL R+YTQNIDGLER++G+  + LVEAHGTFASA+C  C   +    ++  +    +  C  C G+VKPDIVFFGE LP +F L   DF  ADLLL++GTSLEVEPFAS+ ++ R   PR+LINR  VG      R  D   LGD++ G++ L + L W  E+  L++
Sbjct:   30 PFQACGCRLVL-GGRDD-----DVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYP-GNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQ 307

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
Match: SIRT3 (sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931])

HSP 1 Score: 299.286 bits (765), Expect = 5.478e-96
Identity = 140/263 (53.23%), Postives = 181/263 (68.82%), Query Frame = 1

Query:  493 DICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            D+ + I     + +V+M GAGIS PSGIPDFRSPG+GLY NL+QY +PYPEAIF++ +F  NPKPFF LAKEL+P G Y+PN  HYF RLL +K LL R+YTQNIDGLER++G+  + LVEAHGTFASA+C  C   +    ++  +    +  C  C G+VKPDIVFFGE LP +F L   DF  ADLLL++GTSLEVEPFAS+ ++ R   PR+LINR  VG      R  D   LGD++ G++ L + L W  E+  L++
Sbjct:  127 DVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYP-GNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQ 388

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
Match: SIRT3 (sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931])

HSP 1 Score: 291.582 bits (745), Expect = 5.037e-95
Identity = 137/247 (55.47%), Postives = 173/247 (70.04%), Query Frame = 1

Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            M GAGIS PSGIPDFRSPG+GLY NL+QY +PYPEAIF++ +F  NPKPFF LAKEL+P G Y+PN  HYF RLL +K LL R+YTQNIDGLER++G+  + LVEAHGTFASA+C  C   +    ++  +    +  C  C G+VKPDIVFFGE LP +F L   DF  ADLLL++GTSLEVEPFAS+ ++ R   PR+LINR  VG      R  D   LGD++ G++ L + L W  E+  L++
Sbjct:    1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYP-GNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQ 246

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
Match: SIRT2 (sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886])

HSP 1 Score: 270.011 bits (689), Expect = 2.676e-85
Identity = 135/288 (46.88%), Postives = 188/288 (65.28%), Query Frame = 1

Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLYDNL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL++K LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C  +Y  + +KE I       C  C+ +VKPDIVFFGE LP++ F   +SDF + DLLLVMGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LG+   G   L++ L W+ EL+ L++
Sbjct:   23 DELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVR 309

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Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLYDNL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL++K LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C  +Y  + +KE I       C  C+ +VKPDIVFFGE LP++ F   +SDF + DLLLVMGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LG+   G   L++ L W+ EL+ L++
Sbjct:   23 DELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVR 309

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Celegans
Match: sir-2.1 (NAD-dependent protein deacetylase sir-2.1 [Source:UniProtKB/Swiss-Prot;Acc:Q21921])

HSP 1 Score: 189.889 bits (481), Expect = 5.259e-53
Identity = 96/237 (40.51%), Postives = 145/237 (61.18%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRS-DFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGI 1227
            K+I+++ GAG+S   GIPDFRS   G+Y  L+     +P P A+FDI YF +NP PF+  A+E+FP G++ P+  H F + L+    L R YTQNID LE   G+    +VE HG+F+  +C RCG+ Y   +++E +    + +C +C G++KP+IVFFGEDL  +FH   + D  + DL++V+G+SL+V P A I        P++LINR+ +  + +   +  NC   DII  I
Sbjct:  116 KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNC--DDIIRDI 346

[Close]

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRS-DFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGI 1227
            K+I+++ GAG+S   GIPDFRS   G+Y  L+     +P P A+FDI YF +NP PF+  A+E+FP G++ P+  H F + L+    L R YTQNID LE   G+    +VE HG+F+  +C RCG+ Y   +++E +    + +C +C G++KP+IVFFGEDL  +FH   + D  + DL++V+G+SL+V P A I        P++LINR+ +  + +   +  NC   DII  I
Sbjct:  116 KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNC--DDIIRDI 346

[Close]

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRS-DFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGI 1227
            K+I+++ GAG+S   GIPDFRS   G+Y  L+     +P P A+FDI YF +NP PF+  A+E+FP G++ P+  H F + L+    L R YTQNID LE   G+    +VE HG+F+  +C RCG+ Y   +++E +    + +C +C G++KP+IVFFGEDL  +FH   + D  + DL++V+G+SL+V P A I        P++LINR+ +  + +   +  NC   DII  I
Sbjct:  116 KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNC--DDIIRDI 346

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Celegans
Match: sir-2.1 (NAD-dependent protein deacetylase sir-2.1 [Source:UniProtKB/Swiss-Prot;Acc:Q21921])

HSP 1 Score: 189.889 bits (481), Expect = 8.124e-53
Identity = 96/237 (40.51%), Postives = 145/237 (61.18%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRS-DFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGI 1227
            K+I+++ GAG+S   GIPDFRS   G+Y  L+     +P P A+FDI YF +NP PF+  A+E+FP G++ P+  H F + L+    L R YTQNID LE   G+    +VE HG+F+  +C RCG+ Y   +++E +    + +C +C G++KP+IVFFGEDL  +FH   + D  + DL++V+G+SL+V P A I        P++LINR+ +  + +   +  NC   DII  I
Sbjct:  146 KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNC--DDIIRDI 376

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Celegans
Match: sir-2.1 (NAD-dependent protein deacetylase sir-2.1 [Source:UniProtKB/Swiss-Prot;Acc:Q21921])

HSP 1 Score: 189.889 bits (481), Expect = 8.124e-53
Identity = 96/237 (40.51%), Postives = 145/237 (61.18%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRS-DFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGI 1227
            K+I+++ GAG+S   GIPDFRS   G+Y  L+     +P P A+FDI YF +NP PF+  A+E+FP G++ P+  H F + L+    L R YTQNID LE   G+    +VE HG+F+  +C RCG+ Y   +++E +    + +C +C G++KP+IVFFGEDL  +FH   + D  + DL++V+G+SL+V P A I        P++LINR+ +  + +   +  NC   DII  I
Sbjct:  146 KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNC--DDIIRDI 376

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0083882)

HSP 1 Score: 264.233 bits (674), Expect = 2.393e-83
Identity = 133/268 (49.63%), Postives = 174/268 (64.93%), Query Frame = 1

Query:  523 IKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLF-RSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVG---------------VFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
             + IV M GAGIS  +GIPDFRSPG+GLY NLK+Y++P+P AIFD+DYF +NP PFFALAKEL+P G + P   HYF RLL +K LL+R YTQNID L+RL GL +  ++EAHG+F +  C++C ++Y    +K  I    +  C KC+G+VKPDIVFFGE+LP +F+     DFQ  DLL++MGTSLEV+PFAS+V        R+LINR  VG               +F       D   LGD   G+  L+K L W+ EL +L+
Sbjct:   47 FRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYP-GSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLI 313

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0344243)

HSP 1 Score: 264.233 bits (674), Expect = 2.393e-83
Identity = 133/268 (49.63%), Postives = 174/268 (64.93%), Query Frame = 1

Query:  523 IKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLF-RSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVG---------------VFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
             + IV M GAGIS  +GIPDFRSPG+GLY NLK+Y++P+P AIFD+DYF +NP PFFALAKEL+P G + P   HYF RLL +K LL+R YTQNID L+RL GL +  ++EAHG+F +  C++C ++Y    +K  I    +  C KC+G+VKPDIVFFGE+LP +F+     DFQ  DLL++MGTSLEV+PFAS+V        R+LINR  VG               +F       D   LGD   G+  L+K L W+ EL +L+
Sbjct:   47 FRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYP-GSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLI 313

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Match: Sirt1 (gene:FBgn0024291 transcript:FBtr0080434)

HSP 1 Score: 180.259 bits (456), Expect = 2.358e-48
Identity = 96/242 (39.67%), Postives = 144/242 (59.50%), Query Frame = 1

Query:  511 LTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCR------------------------GIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQ 1155
            L  K + I+++ GAG+S   GIPDFRS   G+Y  L      +P P+A+FDI+YF ++P+PF+  A+E++P G+++P+  H F ++L+ K  L R YTQNID LER+AG+    ++E HG+F++ASC +C    +A  L+  I    I  C +C+                        GI+KPDIVFFGE LP ++H +  +D    DLL+V+G+SL+V P A I  S     P++LINR+
Sbjct:  217 LVKKSQKIIVLTGAGVSVSCGIPDFRS-TNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYP-GEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQ--RVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE 454

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Match: Sirt6 (gene:FBgn0037802 transcript:FBtr0305358)

HSP 1 Score: 82.4185 bits (202), Expect = 7.669e-17
Identity = 66/250 (26.40%), Postives = 114/250 (45.60%), Query Frame = 1

Query:  451 LSTPSGTDDQKFIVDICQKI--LTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEI---CYCS------KCR-GIVKPDIVFFGEDLP-SKFHLFRSDFQQADLLLVMGTSLEVEPFASI-VDSTRFGTPRVLINRQP 1158
            L  P   D  + + + CQ++  L  K  ++V+  GAGIS  +GIPDFR P                + ++ ++   +  KP F ++ +     + RP K H     L E   ++ V +QNIDGL   +GL+   L E HG      C +C   + +    E++ +  +   C  S       CR GI+  +++ +  DLP +   +       ADL + +GT+L++ P   + + + + G   V+ N QP
Sbjct:   18 LGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGP----------------KGVWTLEE--KGEKPDFNVSFD-----EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQP 244

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070852)

HSP 1 Score: 78.9518 bits (193), Expect = 1.028e-15
Identity = 69/242 (28.51%), Postives = 107/242 (44.21%), Query Frame = 1

Query:  388 RVSSTSVNKNTSRPFSTFGRYL--STPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNP---KPFFALAKELFPS-GKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLK---------------------------ESIDKSEICYCSKCRGIVKPDIVFFGEDLP 1014
            R  STS+  +T+R       Y+    P   DD K + D     L SK  N++++ GAGIS  SGIPD+RS G GLY       + + E       F+++    K ++A     +P     +PN  H+     + ++ ++ V TQN+D L   AG    N+VE HG+     C+ C       + +                           E I+   I  C++C G +KP+IVFFG+ +P
Sbjct:    8 RFRSTSLRSSTARQ-----EYVPHHKPVVEDDIKRLEDF----LLSK-PNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHME-------FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVP 230

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 323.168 bits (827), Expect = 4.430e-106
Identity = 156/273 (57.14%), Postives = 197/273 (72.16%), Query Frame = 1

Query:  478 QKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVH-DNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            Q+ + DI +KI   K K IV+MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I+YF  NP PFFALAKEL+P G Y+PN  HYF R+L +K+ L R+YTQNIDGLER+AG+    LVEAHGTFA+A+C  C  DY   +L++ I    +  C  C+GI+KPDIVFFGE+LP  F  + +DF  ADLL+VMGTSLEVEPFAS+  + R   PR+LINR  VG F S  + H D   LGD+++G+  L + L W+ EL+ LM  G +
Sbjct:   85 QQTLEDIAEKIRERKFKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPNPFFALAKELYP-GNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKGEELRDDIMAGTVPKCPTCKGIIKPDIVFFGEELPQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVAELGDVVNGVKKLVELLGWKQELEDLMNVGRD 356

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 323.168 bits (827), Expect = 5.043e-106
Identity = 156/273 (57.14%), Postives = 197/273 (72.16%), Query Frame = 1

Query:  478 QKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVH-DNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            Q+ + DI +KI   K K IV+MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I+YF  NP PFFALAKEL+P G Y+PN  HYF R+L +K+ L R+YTQNIDGLER+AG+    LVEAHGTFA+A+C  C  DY   +L++ I    +  C  C+GI+KPDIVFFGE+LP  F  + +DF  ADLL+VMGTSLEVEPFAS+  + R   PR+LINR  VG F S  + H D   LGD+++G+  L + L W+ EL+ LM  G +
Sbjct:   85 QQTLEDIAEKIRERKFKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPNPFFALAKELYP-GNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKGEELRDDIMAGTVPKCPTCKGIIKPDIVFFGEELPQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVAELGDVVNGVKKLVELLGWKQELEDLMNVGRD 356

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 307.375 bits (786), Expect = 1.870e-101
Identity = 147/252 (58.33%), Postives = 184/252 (73.02%), Query Frame = 1

Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVH-DNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I+YF  NP PFFALAKEL+P G Y+PN  HYF R+L +K+ L R+YTQNIDGLER+AG+    LVEAHGTFA+A+C  C  DY   +L++ I    +  C  C+GI+KPDIVFFGE+LP  F  + +DF  ADLL+VMGTSLEVEPFAS+  + R   PR+LINR  VG F S  + H D   LGD+++G+  L + L W+ EL+ LM  G +
Sbjct:    1 MAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPNPFFALAKELYP-GNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKGEELRDDIMAGTVPKCPTCKGIIKPDIVFFGEELPQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVAELGDVVNGVKKLVELLGWKQELEDLMNVGRD 251

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Match: si:dkey-103i16.6 (si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-46])

HSP 1 Score: 307.76 bits (787), Expect = 1.329e-99
Identity = 145/291 (49.83%), Postives = 202/291 (69.42%), Query Frame = 1

Query:  451 LSTPSGTDDQKFIVDICQKILT-SKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNT 1317
            LS+PSG    +  ++   +++   +++NIV++AGAGIS  SGIPDFR+PGTGLY NL +Y IPYPEA+F+IDYF  NP PFF+LAKEL+P G +RPN VHYF R+L +K LL R+YTQNIDGLE+L G+ D  LVEAHG+FA+A+C  C   Y A + K++I    +  C+ C G VKP++VFFGEDLP K+     DF +ADLL++MGTSL++EPFAS++++ +   PR+L+NR  VG F R   R  D   LGD+ + +  L++ L W  E+  LM   E    ++ ++
Sbjct:   89 LSSPSGRSVSRGALETIGRLMKLGRVRNIVVVAGAGISTASGIPDFRTPGTGLYANLAKYDIPYPEAVFNIDYFSDNPHPFFSLAKELYP-GHHRPNYVHYFIRMLHQKGLLLRMYTQNIDGLEKLCGIPDDKLVEAHGSFATAACHLCYTPYPAEEAKQAIMNGSVPICTFCAGAVKPNVVFFGEDLPEKYFQHAEDFPKADLLMIMGTSLKIEPFASLINTVKSTVPRLLLNRDAVGPFERRPLRRADYMELGDLSESVRKLAEILGWHTEIQTLMNSHENGLYSYISS 378

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Match: si:dkey-103i16.6 (si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-46])

HSP 1 Score: 303.523 bits (776), Expect = 3.293e-98
Identity = 149/312 (47.76%), Postives = 210/312 (67.31%), Query Frame = 1

Query:  397 STSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILT-SKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEV---EPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNT 1317
            +++  K +S+P       LS+PSG    +  ++   +++   +++NIV++AGAGIS  SGIPDFR+PGTGLY NL +Y IPYPEA+F+IDYF  NP PFF+LAKEL+P G +RPN VHYF R+L +K LL R+YTQNIDGLE+L G+ D  LVEAHG+FA+A+C  C   Y A + K++I    +  C+ C G VKP++VFFGEDLP K+     DF +ADLL++MGTSL+V   EPFAS++++ +   PR+L+NR  VG F R   R  D   LGD+ + +  L++ L W  E+  LM   E    ++ ++
Sbjct:   55 ASATRKGSSKP------ALSSPSGRSVSRGALETIGRLMKLGRVRNIVVVAGAGISTASGIPDFRTPGTGLYANLAKYDIPYPEAVFNIDYFSDNPHPFFSLAKELYP-GHHRPNYVHYFIRMLHQKGLLLRMYTQNIDGLEKLCGIPDDKLVEAHGSFATAACHLCYTPYPAEEAKQAIMNGSVPICTFCAGAVKPNVVFFGEDLPEKYFQHAEDFPKADLLIIMGTSLKVGLIEPFASLINTVKSTVPRLLLNRDAVGPFERRPLRRADYMELGDLSESVRKLAEILGWHTEIQTLMNSHENGLYSYISS 359

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Match: hoga1 (4-hydroxy-2-oxoglutarate aldolase 1 [Source:Xenbase;Acc:XB-GENE-957775])

HSP 1 Score: 308.145 bits (788), Expect = 1.563e-99
Identity = 171/354 (48.31%), Postives = 218/354 (61.58%), Query Frame = 1

Query:  235 QYSNGKVEQSENNLHNIPRQTALNGKLLFRENTSIASNKIEKSKLPSR--NNDRVSST---SVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKR-RVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
            Q+ + K+E S  N       +A    ++  +N   A++    ++  SR   N R+S     S  +    P S   + +S          + DI   I  +   NI++MAGAGIS  SGIPDFR+PG+GLYDNL++Y IPYPEAIFDI+YF+ NP PFF LAKELFP GKY+PN VHYF +LL +K LL R YTQNIDGLERLAG+    +VE HGTF SASC  C   + A + KE I       C  C G VKPDIVFFGEDLP  F     DF +ADLL++MGTSL++EPFAS+V++ +   PR+LINR+ VG F  KR R  D   LGD+ D I  +   L W+ ELD+LM
Sbjct:   32 QWPDAKMEVSATN-------SAFQTTVINNQNAQEAADLKHPTEYHSRKRENGRLSGIIKQSCLRKRQLPKSALAKNISAIKPNIGCNNLEDILDLITKNCCTNIIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDINYFVCNPNPFFHLAKELFP-GKYKPNLVHYFIKLLHDKGLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASCSLCYTPFPANEAKELIFDGNPPCCKFCAGPVKPDIVFFGEDLPQTFTQAYQDFPKADLLIIMGTSLKIEPFASLVNTVKPSIPRLLINREKVGPFAKKRLRRRDVAELGDLCDIIHTMVSRLSWQAELDQLM 377

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Match: SIRT2 (sirtuin 2 [Source:NCBI gene;Acc:100489469])

HSP 1 Score: 290.426 bits (742), Expect = 1.704e-92
Identity = 152/296 (51.35%), Postives = 196/296 (66.22%), Query Frame = 1

Query:  451 LSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV---------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKE 1284
            + TP    D+  I  I + +L+ K KN+V M GAGIS  +GIPDFRSPG+GLY NL++Y +PYPEAIF I YF +NP+PFFALA+ELFP G+++P   HYF RLL+EK LL R Y+QNID LER+AGL   +LVEAHGTF S+ CV   C  +YS + +KE I    I  C KC  +VKPDIVFFGE LPS+ F   +SDF + DLL+VMGTSL+V+PFAS+V      TPR+LIN++  G                F S++   D   LGD  DG   L+  L W+ EL++L+K+
Sbjct:   81 IGTPEKVLDELSIEGISRFMLSEKCKNVVCMVGAGISTSAGIPDFRSPGSGLYSNLQKYNLPYPEAIFQIGYFKENPEPFFALARELFP-GQFKPTICHYFIRLLKEKGLLLRCYSQNIDTLERVAGLTSDDLVEAHGTFHSSHCVDTFCRAEYSLSWMKEKIFSDLIPKCEKCNNLVKPDIVFFGESLPSRFFSAIKSDFPKVDLLIVMGTSLQVQPFASLVSKVSSKTPRLLINKELAGQGDPFFSVFGFGGGMDFDSEKAYRDVAWLGDCDDGCLALADFLGWKAELEELVKK 375

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Match: SIRT3 (sirtuin 3 [Source:NCBI gene;Acc:100487410])

HSP 1 Score: 286.574 bits (732), Expect = 1.218e-91
Identity = 140/285 (49.12%), Postives = 193/285 (67.72%), Query Frame = 1

Query:  454 STPSGTDDQK----FIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            + P G  D +     + DI  +I     + I++M GAGIS  SGIPDFRSP +GLY  L++Y +PYPEAIFD+ YFL+ P+PF  LA++L P G + PN  H+F RLL +K++L R+YTQNIDGLER AG+    LVEAHG+F+SA+C  C + Y     ++++ +S++  CS C G++K DIVFFGE LP +F L  +DF +ADLL V+GTSLEVEPFAS+V + R  TPRVLINR  VG F S  +  +   LG++  GI    + L W+ EL++L K G+++
Sbjct:   75 AHPGGGGDSRNTCLSLEDIALQIKEGLYRRILVMVGAGISTDSGIPDFRSPTSGLYSRLQEYNLPYPEAIFDLRYFLREPQPFLHLARDLLP-GHHHPNTAHHFLRLLSDKEVLLRLYTQNIDGLERAAGIPSEKLVEAHGSFSSATCTMCLKSYPGETFQKAVMESKVPLCSSCGGLIKADIVFFGEQLPPRFLLHLTDFPRADLLFVIGTSLEVEPFASLVYAVRASTPRVLINRDSVGPFVSGPQGLNVLELGEVTAGIKQFVQFLGWQQELEELEKNGKQH 358

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Match: SIRT3 (sirtuin 3 [Source:NCBI gene;Acc:100487410])

HSP 1 Score: 284.263 bits (726), Expect = 5.256e-91
Identity = 140/285 (49.12%), Postives = 193/285 (67.72%), Query Frame = 1

Query:  454 STPSGTDDQK----FIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            + P G  D +     + DI  +I     + I++M GAGIS  SGIPDFRSP +GLY  L++Y +PYPEAIFD+ YFL+ P+PF  LA++L P G + PN  H+F RLL +K++L R+YTQNIDGLER AG+    LVEAHG+F+SA+C  C + Y     ++++ +S++  CS C G++K DIVFFGE LP +F L  +DF +ADLL V+GTSLEVEPFAS+V + R  TPRVLINR  VG F S  +  +   LG++  GI    + L W+ EL++L K G+++
Sbjct:   56 AHPGGGGDSRNTCLSLEDIALQIKEGLYRRILVMVGAGISTDSGIPDFRSPTSGLYSRLQEYNLPYPEAIFDLRYFLREPQPFLHLARDLLP-GHHHPNTAHHFLRLLSDKEVLLRLYTQNIDGLERAAGIPSEKLVEAHGSFSSATCTMCLKSYPGETFQKAVMESKVPLCSSCGGLIKADIVFFGEQLPPRFLLHLTDFPRADLLFVIGTSLEVEPFASLVYAVRASTPRVLINRDSVGPFVSGPQGLNVLELGEVTAGIKQFVQFLGWQQELEELEKNGKQH 339

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Match: SIRT2 (sirtuin 2 [Source:NCBI gene;Acc:100489469])

HSP 1 Score: 266.159 bits (679), Expect = 1.424e-84
Identity = 143/273 (52.38%), Postives = 182/273 (66.67%), Query Frame = 1

Query:  451 LSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV-FRSKRRVHDNCVLGDIIDGIDVLSKNLRWE 1257
            + TP    D+  I  I + +L+ K KN+V M GAGIS  +GIPDFRSPG+GLY NL++Y +PYPEAIF I YF +NP+PFFALA+ELFP G+++P   HYF RLL+EK LL R Y+QNID LER+AGL   +LVEAHGTF S+ CV   C  +YS + +KE I    I  C KC  +VKPDIVFFGE LPS+F    +SDF + DLL+VMGTSL+V+PFAS+      G P   +     G+ F S++   D   LGD  DG   L+  L W+
Sbjct:   27 IGTPEKVLDELSIEGISRFMLSEKCKNVVCMVGAGISTSAGIPDFRSPGSGLYSNLQKYNLPYPEAIFQIGYFKENPEPFFALARELFP-GQFKPTICHYFIRLLKEKGLLLRCYSQNIDTLERVAGLTSDDLVEAHGTFHSSHCVDTFCRAEYSLSWMKEKIFSDLIPKCEKCNNLVKPDIVFFGESLPSRFFSAIKSDFPKVDLLIVMGTSLQVQPFASL------GDPFFSVFGFGGGMDFDSEKAYRDVAWLGDCDDGCLALADFLGWK 292

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
Match: Sirt3 (sirtuin 3 [Source:MGI Symbol;Acc:MGI:1927665])

HSP 1 Score: 290.812 bits (743), Expect = 5.929e-95
Identity = 139/247 (56.28%), Postives = 173/247 (70.04%), Query Frame = 1

Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            M GAGIS PSGIPDFRSPG+GLY NL+QY IPYPEAIF++ +F  NPKPFF LAKEL+P G YRPN  HYF RLL +K+LL R+YTQNIDGLER +G+  + LVEAHGTF +A+C  C   +    +   +    +  C  C G+VKPDIVFFGE LP++F L  +DF  ADLLL++GTSLEVEPFAS+ ++ +   PR+LINR  VG F    R  D   LGD++ G++ L   L W  EL  LM+
Sbjct:    1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYP-GHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQ 246

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Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            M GAGIS PSGIPDFRSPG+GLY NL+QY IPYPEAIF++ +F  NPKPFF LAKEL+P G YRPN  HYF RLL +K+LL R+YTQNIDGLER +G+  + LVEAHGTF +A+C  C   +    +   +    +  C  C G+VKPDIVFFGE LP++F L  +DF  ADLLL++GTSLEVEPFAS+ ++ +   PR+LINR  VG F    R  D   LGD++ G++ L   L W  EL  LM+
Sbjct:    1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYP-GHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQ 246

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
Match: Sirt2 (sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664])

HSP 1 Score: 272.707 bits (696), Expect = 1.650e-86
Identity = 136/293 (46.42%), Postives = 190/293 (64.85%), Query Frame = 1

Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL+EK LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C ++Y+   +KE I       C +C+ +VKPDIVFFGE+LPS+ F   +SDF + DLL++MGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LGD   G   L+  L W+ EL+ L++    N
Sbjct:   23 DELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHAN 314

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
Match: Sirt2 (sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664])

HSP 1 Score: 270.781 bits (691), Expect = 2.987e-86
Identity = 135/276 (48.91%), Postives = 182/276 (65.94%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            + ++ + GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL+EK LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C ++Y+   +KE I       C +C+ +VKPDIVFFGE+LPS+ F   +SDF + DLL++MGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LGD   G   L+  L W+ EL+ L++    N
Sbjct:    7 RKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHAN 281

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
Match: Sirt2 (sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664])

HSP 1 Score: 272.707 bits (696), Expect = 4.444e-86
Identity = 136/293 (46.42%), Postives = 190/293 (64.85%), Query Frame = 1

Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL+EK LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C ++Y+   +KE I       C +C+ +VKPDIVFFGE+LPS+ F   +SDF + DLL++MGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LGD   G   L+  L W+ EL+ L++    N
Sbjct:   60 DELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHAN 351

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BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Match: sp|Q8R104|SIR3_MOUSE (NAD-dependent protein deacetylase sirtuin-3 OS=Mus musculus OX=10090 GN=Sirt3 PE=1 SV=2)

HSP 1 Score: 299.671 bits (766), Expect = 2.210e-96
Identity = 144/270 (53.33%), Postives = 186/270 (68.89%), Query Frame = 1

Query:  475 DQKF-IVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            ++KF + D+ + + T     +V+M GAGIS PSGIPDFRSPG+GLY NL+QY IPYPEAIF++ +F  NPKPFF LAKEL+P G YRPN  HYF RLL +K+LL R+YTQNIDGLER +G+  + LVEAHGTF +A+C  C   +    +   +    +  C  C G+VKPDIVFFGE LP++F L  +DF  ADLLL++GTSLEVEPFAS+ ++ +   PR+LINR  VG F    R  D   LGD++ G++ L   L W  EL  LM+
Sbjct:   55 EKKFSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYP-GHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQ 323

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BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Match: sp|Q9NTG7|SIR3_HUMAN (NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2)

HSP 1 Score: 299.286 bits (765), Expect = 2.631e-95
Identity = 140/263 (53.23%), Postives = 181/263 (68.82%), Query Frame = 1

Query:  493 DICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            D+ + I     + +V+M GAGIS PSGIPDFRSPG+GLY NL+QY +PYPEAIF++ +F  NPKPFF LAKEL+P G Y+PN  HYF RLL +K LL R+YTQNIDGLER++G+  + LVEAHGTFASA+C  C   +    ++  +    +  C  C G+VKPDIVFFGE LP +F L   DF  ADLLL++GTSLEVEPFAS+ ++ R   PR+LINR  VG      R  D   LGD++ G++ L + L W  E+  L++
Sbjct:  127 DVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYP-GNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQ 388

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BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Match: sp|Q7ZVK3|SIR2_DANRE (NAD-dependent protein deacetylase sirtuin-2 OS=Danio rerio OX=7955 GN=sirt2 PE=1 SV=1)

HSP 1 Score: 277.715 bits (709), Expect = 2.883e-87
Identity = 148/327 (45.26%), Postives = 203/327 (62.08%), Query Frame = 1

Query:  367 LPSRNNDRVSSTSVNKNTSRPF--STFGRYLSTPSGTD--DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV---------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            L  +++D       + +T   F  S F R L    G    D+  +  + + IL+ K KNI+ M GAGIS  +GIPDFRSPGTGLY NL++Y +PYPEAIF IDYF ++P+PFFALA+EL+P G+++P   HYF ++L++K LLRR Y+QNID LER+AGL   +L+EAHGTF ++ CV   C ++YS   +K  I   EI  C  C  +VKPDIVFFGE LPS+F    ++DF Q DLL++MGTSL+V+PFAS+V       PR+LIN +  G                F S +   D   L    DG   L++ L W+ EL++++K
Sbjct:   18 LEGQSDDSSDEGDASGDTEMDFLRSLFSRTLGLSPGDKVLDELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIFQIDYFKKHPEPFFALARELYP-GQFKPTVYHYFIKMLKDKGLLRRCYSQNIDTLERVAGLEGEDLIEAHGTFHTSHCVSFLCRKEYSMDWMKNQIFSEEIPKCDSCGSLVKPDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFASLVSRVSNRCPRLLINMEKTGQSEFGMGLFSFGGGMDFDSDKAYRDVAHLSTCDDGCMTLAELLGWKKELEEMVK 343

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BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Match: sp|Q5RJQ4|SIR2_RAT (NAD-dependent protein deacetylase sirtuin-2 OS=Rattus norvegicus OX=10116 GN=Sirt2 PE=1 SV=1)

HSP 1 Score: 272.322 bits (695), Expect = 1.562e-85
Identity = 137/293 (46.76%), Postives = 191/293 (65.19%), Query Frame = 1

Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL+EK LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   CG++Y+ + +KE I       C KC+ +VKPDIVFFGE+LP + F   +SDF + DLL++MGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LGD   G   L+  L W+ EL+ L++    N
Sbjct:   23 DELTLEGVTRYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCGKEYTMSWMKEKIFSEATPKCEKCQNVVKPDIVFFGENLPPRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWK-ELEDLVRREHAN 313

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BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Match: sp|Q8VDQ8|SIR2_MOUSE (NAD-dependent protein deacetylase sirtuin-2 OS=Mus musculus OX=10090 GN=Sirt2 PE=1 SV=2)

HSP 1 Score: 272.707 bits (696), Expect = 3.109e-85
Identity = 136/293 (46.42%), Postives = 190/293 (64.85%), Query Frame = 1

Query:  475 DQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCV--RCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            D+  +  + + + + + + ++ + GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF+I YF ++P+PFFALAKEL+P G+++P   HYF RLL+EK LL R YTQNID LER+AGL   +LVEAHGTF ++ CV   C ++Y+   +KE I       C +C+ +VKPDIVFFGE+LPS+ F   +SDF + DLL++MGTSL+V+PFAS++      TPR+LIN++  G                 F SK+   D   LGD   G   L+  L W+ EL+ L++    N
Sbjct:   60 DELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHAN 351

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BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Match: A0A1S3JTY3 (NAD-dependent protein deacetylase sirtuin-3 OS=Lingula unguis OX=7574 GN=LOC106176139 PE=4 SV=1)

HSP 1 Score: 357.066 bits (915), Expect = 3.594e-114
Identity = 166/269 (61.71%), Postives = 208/269 (77.32%), Query Frame = 1

Query:  493 DICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESI--DKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            D+ + I   + KNIV+MAGAGIS PSGIPDFRSPGTGLYDNL+QY IPYPEAIFDIDYF  NP+PFFAL+KEL+PSGKYRPN +HYF RLL +K LL R+YTQNIDGLERLAG+    LVEAHGTF++A+C+RC  ++   ++K++I  DK   C  + C GIVKPDIVFFGE+LP +F+ +  DF QADL+LV+GTSLEVEPFASIVD++R   PRVL NR+ VG F+ KRR +D    GD+I  +    + L W+ +++ LMKE E+
Sbjct:  101 DVSRYIREGRAKNIVVMAGAGISTPSGIPDFRSPGTGLYDNLQQYNIPYPEAIFDIDYFHMNPRPFFALSKELYPSGKYRPNYIHYFMRLLHDKGLLHRMYTQNIDGLERLAGIPSEKLVEAHGTFSTATCIRCNLEHRGDEIKDAIFSDKLPKCKKTNCLGIVKPDIVFFGEELPRRFYYYLKDFPQADLVLVLGTSLEVEPFASIVDASRSYIPRVLFNREAVGPFKRKRRNNDVVSEGDLIANVQKFVRILEWQKDMEYLMKENEK 369

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BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Match: C3Z1Z2 (Deacetylase sirtuin-type domain-containing protein (Fragment) OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_223028 PE=4 SV=1)

HSP 1 Score: 335.495 bits (859), Expect = 8.316e-109
Identity = 165/268 (61.57%), Postives = 203/268 (75.75%), Query Frame = 1

Query:  487 IVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSK---CRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
            I D+ + IL +K KN+V+MAGAGIS PSGIPDFRSPGTGLYDNL+QY IPYPEAIFDIDYF  + +PF+ LAKEL+P G YRPN VHYF RLL EK LL R+YTQNIDGLER++G+ ++ LVEAHGTFA+ASC+RC   YS  Q+K +I K +I  C+    C+G +KPDIVFFGEDLP +F+ +  DF   DLLLVMGTSLEVEPFASIV+S+R   PRVL NR PVG F R   R  D   LGD++ GI   ++ L W+  +++L+
Sbjct:    1 IDDVARYILANKCKNVVVMAGAGISTPSGIPDFRSPGTGLYDNLQQYNIPYPEAIFDIDYFHMDSRPFYTLAKELYP-GNYRPNYVHYFIRLLHEKGLLLRMYTQNIDGLERMSGIPESKLVEAHGTFATASCIRCNAKYSGKQIKAAIMKGDIPKCTNSKWCKGKIKPDIVFFGEDLPRRFYYYLKDFPLCDLLLVMGTSLEVEPFASIVNSSRGYVPRVLFNRDPVGPFGRVPLRDTDCAELGDLVQGIQRFTRILGWKQAMEELV 267

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BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Match: H2ZB27 (NAD-dependent protein deacetylase OS=Ciona savignyi OX=51511 PE=3 SV=1)

HSP 1 Score: 331.643 bits (849), Expect = 3.875e-107
Identity = 161/268 (60.07%), Postives = 193/268 (72.01%), Query Frame = 1

Query:  487 IVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCS---KCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            I D+ + I +  +KNI++MAGAGIS  SGIPDFRSPGTGLYDNL++YK+PYP A+FD+DYF  NPKPFF LAKEL+PSGKYRPN VHYF R L E+ LL R+YTQNIDGLERLAG+    LVEAHGTF SASC +CG+ Y+   +K+ I K     C     C GI+KPDIVFFGEDLP +F+ +  DF   DLLLVMGTSL+VEPFAS+VDSTR  TPR+L+N   VG F    R  D  + GDI D I  L+  L W   L + M+
Sbjct:   16 IEDVARIIKSEGVKNIIVMAGAGISTASGIPDFRSPGTGLYDNLQKYKVPYPTAVFDLDYFHSNPKPFFELAKELYPSGKYRPNAVHYFVRCLHERGLLLRMYTQNIDGLERLAGIPPMKLVEAHGTFTSASCTKCGKKYNGETIKDKILKGATPRCQLTPLCYGIIKPDIVFFGEDLPKRFYYYLKDFPACDLLLVMGTSLQVEPFASLVDSTRATTPRLLLNMVKVGPFTKPSRRTDLSITGDISDSIHKLADALDWREFLQETME 283

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BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Match: A0A3B4Z9K6 (NAD-dependent protein deacetylase OS=Stegastes partitus OX=144197 PE=3 SV=1)

HSP 1 Score: 332.798 bits (852), Expect = 1.292e-106
Identity = 166/326 (50.92%), Postives = 211/326 (64.72%), Query Frame = 1

Query:  316 LFRENTSIASNKIEKSKLPSRNNDRVSSTSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            L+R   S A+  I  +    R ++  ++ S   ++S    T G + S    +D Q+ +  I +KI   K K +V+MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I +F +NP PFFALAKEL+P G Y+PN  HYF RLL EK  L R+YTQNIDGLERLAG+    LVEAHGTFA+A+C  C   Y    L+  +    +  C  C+G+VKPDIVFFGE+LP  F  + +DF  ADLL++MGTSLEVEPFAS+  + R   PR+LINR  VG F   RR  D   LGD++ G+  L   L W  EL+ LM  G E
Sbjct:   18 LYRSLCSGANRTISANGFGQRTSEGAAALSRRIHSSCWNGTRGFFSSGDGASDQQQTLEGIAKKIREKKYKRVVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEIGFFHRNPDPFFALAKELYP-GNYQPNLTHYFVRLLHEKDQLLRMYTQNIDGLERLAGIPPAMLVEAHGTFATATCTVCLRKYEGEDLRPDVMSGTVPKCPTCKGVVKPDIVFFGEELPRHFFKYLTDFPLADLLIIMGTSLEVEPFASLAGAVRSSVPRLLINRDLVGPFAWSRRPQDVVQLGDVVSGVQALVDALGWTQELEALMAAGAE 342

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BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Match: A0A068WY32 (NAD dependent deacetylase sirtuin 3 OS=Echinococcus granulosus OX=6210 GN=EgrG_001176600 PE=4 SV=1)

HSP 1 Score: 334.339 bits (856), Expect = 4.356e-106
Identity = 159/297 (53.54%), Postives = 211/297 (71.04%), Query Frame = 1

Query:  496 ICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNTISKIKRNSIPNSRNYSTFANTTR 1386
            +   I   K  +I++MAGAGIS  SGIPDFRSP TGLY NLK+YK+PYPEAIFDI+YF   P  F+ALAKEL+P+GKYRPN  HYFFRLL +K+LLRRVYTQNIDGLER+AG+  + LVEAHGTFA+A C++C +   A  +K +ID+ ++  C +CRG+VKPDIVF+ EDLP+KF  +R D  + DL++VMGTSLEV+PF+ ++ +T   TPRVL N+  VG F+++RR  D   LGDI   I  L   L W  EL+ LMK+ E  +I++   +S +  N++   +N     N +R
Sbjct:    8 VAHLISEGKAHDIIVMAGAGISTASGIPDFRSPKTGLYANLKKYKLPYPEAIFDINYFKIRPSAFYALAKELYPTGKYRPNIAHYFFRLLNQKRLLRRVYTQNIDGLERVAGIPASKLVEAHGTFATAQCLKCEKSIPARMVKAAIDRGKVARCYRCRGLVKPDIVFYNEDLPAKFWRYREDIPKGDLIIVMGTSLEVQPFSKLIAATHSNTPRVLFNKHIVGPFKTRRRPKDFVALGDISTLIRELCALLEWTDELEDLMKDAELRRIDYIG-LSPLNVNAMLRLQNEHRRRNESR 303

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Match: sirt3 (sirtuin 3 [Source:NCBI gene;Acc:103044645])

HSP 1 Score: 311.612 bits (797), Expect = 1.081e-101
Identity = 150/263 (57.03%), Postives = 188/263 (71.48%), Query Frame = 1

Query:  493 DICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCV-LGDIIDGIDVLSKNLRWEIELDKLM 1278
            DI + I   + K IV+MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I+YF  NPKPFFALAKEL+P G Y+PN  HYF RLL +K  L R+YTQNIDGLER+AG+    LVEAHGTFA+A+C  C  DY   +L+  I    +  C  C+G++KPDIVFFGE+LP  F L+ +DF  ADL++VMGTSLEVEPFAS+  + R    R+LINR  VG F      H++   LGD++ G+  L++ L W  EL+ LM
Sbjct:   79 DIAKGIRDREYKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPKPFFALAKELYP-GNYQPNLTHYFIRLLHDKGQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKGEELRNDIMAGTVPNCPHCKGVIKPDIVFFGEELPQHFFLYLTDFPIADLVIVMGTSLEVEPFASLAGAVRGSVSRLLINRDLVGPFAWGSPRHNDVAELGDVVSGVRRLAEALGWMPELEALM 340

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Match: si:dkey-103i16.6 (si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-46])

HSP 1 Score: 298.516 bits (763), Expect = 8.326e-96
Identity = 136/258 (52.71%), Postives = 186/258 (72.09%), Query Frame = 1

Query:  520 KIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGE 1290
            +++N+V++AGAGIS  SGIPDFR+PGTGLY NL++Y +PYPEA+F+IDYF  +P+PFF+LAKEL+P G++RPN +HYF R+L +K LL R+YTQNIDGLE++ G+ D  LVEAHG+FA+ASC  C   + + + KE+I    I  CS C   VKP +VFFGEDLP  +     DF +ADLL++MGTSL++EPFAS+V++ +   PR+L+NR  VG F R   R  D   LGD++  +  L++ L W  E+  LM   E
Sbjct:  120 RLRNVVVVAGAGISTASGIPDFRTPGTGLYANLEKYNVPYPEAVFNIDYFSDDPRPFFSLAKELYP-GRHRPNYIHYFIRMLHQKGLLLRMYTQNIDGLEKMCGIPDDKLVEAHGSFATASCHLCYTPFPSEEAKEAIMSDNIPTCSFCSATVKPSVVFFGEDLPETYFQHAQDFPKADLLIIMGTSLQIEPFASLVNTVKSTVPRLLLNRHAVGPFERKPLRRRDYLELGDLVHSVRKLAEILGWHTEIQDLMNSHE 376

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Match: si:dkey-103i16.6 (si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-46])

HSP 1 Score: 287.73 bits (735), Expect = 1.383e-93
Identity = 135/255 (52.94%), Postives = 184/255 (72.16%), Query Frame = 1

Query:  517 SKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
             +++N+V++AGAGIS  SGIPDFR+PGTGLY NL++Y +PYPEA+F+IDYF  +P+PFF+LAKEL+P G++RPN +HYF R+L +K LL R+YTQNIDGLE++ G+ D  LVEAHG+FA+ASC  C   Y+    +E+I    I  CS C   VKP +VFFGEDLP  +     DF +ADLL++MGTSL++EPFAS+V++ +   PR+L+NR  VG F R   R  D   LGD++  +  L++ L W  E+  LM
Sbjct:    4 GRLRNVVVVAGAGISTASGIPDFRTPGTGLYANLEKYNVPYPEAVFNIDYFSDDPRPFFSLAKELYP-GRHRPNYIHYFIRMLHQKGLLLRMYTQNIDGLEKMCGIPDDKLVEAHGSFATASCHLC---YTPFPSEEAIMSDNIPTCSFCSATVKPSVVFFGEDLPETYFQHAQDFPKADLLIIMGTSLQIEPFASLVNTVKSTVPRLLLNRHAVGPFERKPLRRRDYLELGDLVHSVRKLAEILGWHTEIQDLM 254

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Match: sirt2 (sirtuin 2 [Source:NCBI gene;Acc:103038996])

HSP 1 Score: 269.24 bits (687), Expect = 8.125e-85
Identity = 135/280 (48.21%), Postives = 184/280 (65.71%), Query Frame = 1

Query:  496 ICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV---------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            + + I + K KNI+ M GAGIS  +GIPDFRSPGTGLY NL++Y +PYPEAIF IDYF ++P+PFFALA+EL+P G+++P   HYF R+L++K LLRR Y+QNID LER+AGL   +L+EAHGTF ++ CV   C ++Y+   +KE I   +I  C  C  +VKPDIVFFGE+LP++F    + DF   DLL++MGTSL+V+PFAS+V       PR+LIN +  G                F S +   D   L    DG    ++ L W+ EL++L+K
Sbjct:   67 VARYIQSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIFQIDYFKKHPEPFFALARELYP-GQFKPTVCHYFIRMLKDKGLLRRCYSQNIDTLERVAGLEGEDLIEAHGTFHTSHCVSLFCRKEYTMDWMKEKIFSEDIPKCDACNNLVKPDIVFFGENLPARFFTTMKKDFPHCDLLIIMGTSLQVQPFASLVSRVPNSCPRLLINMEKTGQSEFGMGLLGFGGGMDFDSDKAYRDVAHLSTCDDGCLAFAELLGWKGELEELVK 345

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Match: ENSAMXT00000003809.2 (pep primary_assembly:Astyanax_mexicanus-2.0:25:45151234:45158481:-1 gene:ENSAMXG00000003731.2 transcript:ENSAMXT00000003809.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 190.66 bits (483), Expect = 6.515e-52
Identity = 98/219 (44.75%), Postives = 142/219 (64.84%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCR----GIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPV 1161
            K I+++ GAG+S   GIPDFRS   G+Y  L      +P P+A+FDIDYF ++P+PFF  AKE++P G+++P+  H F  +L +K+ L R YTQNID LE++AG+    +++ HG+FA+ASC+ C        ++E I +  + +C KC      I+KPDIVFFGE+LP  FH   + D    DLL+V+G+SL+V P A I  S     P+VLINR+P+
Sbjct:  290 KKILVLTGAGVSVSCGIPDFRS-RDGIYARLAVDFPDLPDPQAMFDIDYFRRDPRPFFKFAKEIYP-GQFQPSLCHRFISMLDKKEKLLRNYTQNIDTLEQVAGVQ--KIIQCHGSFATASCLVCKHKVDCEAVREDIFRQVVPHCPKCPDIPFAIMKPDIVFFGENLPESFHRAMKQDKDAVDLLIVIGSSLKVRPVALIPSSVPHDVPQVLINREPL 504

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 288.5 bits (737), Expect = 2.344e-94
Identity = 143/263 (54.37%), Postives = 192/263 (73.00%), Query Frame = 1

Query:  493 DICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLM 1278
            D+ + I     KNIV+MAGAG+S  SGIPDFR+PGTGLYDNL++Y +P+PEA+FD+D+F  +PKPFF LA+EL+P G  RPN  HYF RLL E++LL R+YTQNIDGLER+AGL    LVEAHGTFASA+C +C +     Q++ ++   +I +C  C  +VKPDIVFFGEDLP +F+ +  DF  ADLL+V+GTSLEV PFA +V + R G PR+L+NR+ VG+F R+     D   L D++ G+  L+  + W+ ELD+L+
Sbjct:   16 DVARLIRDGHCKNIVLMAGAGMSTASGIPDFRTPGTGLYDNLQRYHLPFPEAVFDLDFFAVDPKPFFTLAQELYP-GNCRPNDAHYFARLLHERRLLLRLYTQNIDGLERVAGLPPDMLVEAHGTFASATCTQCRKPQPGDQVRRTVMSGKIPHCGACSAVVKPDIVFFGEDLPRRFYAYDQDFSMADLLIVIGTSLEVMPFAGLVSAVRPGVPRLLLNREAVGLFRRAASSPTDVAHLDDVVAGVRRLTNLVGWDAELDRLI 277

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
Match: sirt2 (sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) [Source:NCBI gene;Acc:322309])

HSP 1 Score: 276.174 bits (705), Expect = 1.710e-88
Identity = 140/278 (50.36%), Postives = 183/278 (65.83%), Query Frame = 1

Query:  496 ICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV---------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMK 1281
            + + IL  K KNIV M GAGIS  +GIPDFRSPGTGLYDNL++Y +P+P+A+FDI YF +NP+PFFALAKEL+P G+++P   HYF RLL++K+ L R YTQNID LER+AGL +  LVEAHGTF ++ C+ C  +Y  + +KE I   ++  C KC+ +VKPDIVFFGE LP KF    +SDF + DLL++MGTSL V+PFAS+       TPR+LIN +  G                F S     D   LG   DG    ++ L W+ EL+ L+K
Sbjct:   32 VAKHILAGKCKNIVCMVGAGISTAAGIPDFRSPGTGLYDNLQKYNLPHPQAVFDIGYFRENPEPFFALAKELYP-GQFKPTVSHYFIRLLKDKECLLRCYTQNIDTLERVAGLENNELVEAHGTFHTSHCLGCRHEYCLSWMKEQIFSDKVPRCEKCKSVVKPDIVFFGEALPEKFFTCVQSDFPKCDLLIIMGTSLVVQPFASLTSRVPDSTPRLLINLEKSGQCDPMLAALGLGSGFDFDSDDAYRDVAWLGTCDDGCLEFAELLGWKDELNALVK 308

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
Match: sirt6 (sirtuin 6 [Source:ZFIN;Acc:ZDB-GENE-031007-2])

HSP 1 Score: 82.8037 bits (203), Expect = 1.135e-17
Identity = 64/222 (28.83%), Postives = 99/222 (44.59%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESID---KSEICYCSK------CRGIVKPDIVFFGEDLPSK-FHLFRSDFQQADLLLVMGTSLEVEPFASI-VDSTRFGTPRVLINRQP 1158
            K +VI  GAG+S  +GIPDF   G              P  ++ ++     PK  F +  E       RP   H     L  + LL+ + +QN+DGL   +G     L E HG      C RCG+ Y       ++      +IC   K      CRG +K  I+ + + LP +   L     + ADL + +GT+L+++P  S+ + + R G   V++N QP
Sbjct:   45 KYMVIHTGAGVSTAAGIPDFSYRG--------------PNGVWTMEQKGLTPK--FNITFE-----DARPTATHMAMLGLYREGLLKHLVSQNVDGLHIRSGFPRDKLSELHGNMFIEECERCGKQYVRDHTVGTMGLKYTGKICDVVKARGLRGCRGKLKDTILDWEDSLPERDLTLAEKACRNADLTITLGTTLQIKPSGSLPLLTKRNGGKLVIVNLQP 245

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 79.7221 bits (195), Expect = 1.082e-16
Identity = 65/259 (25.10%), Postives = 108/259 (41.70%), Query Frame = 1

Query:  445 RYLSTPSGTDDQKFIVDICQKILTSK----------IKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPE----AIFDIDYFLQN--PKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKE----------------------------SIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEV 1089
            R+ S+P+ + D  F V  C    T +           + + ++AGAG+S  SGIPD+RS G GLY    +  + + E    A+    Y+ +N    P F+           RPN  H      +++  L  + TQN+D L   AG     + E HG      C+ C E    T+L++                             ++   +  C  C G +KP++ FFG+++  +         ++D +LV G+SL+V
Sbjct:   15 RWCSSPAASPDLAF-VPACAPAGTQQRGQLQDFLANSRRLFVLAGAGLSTESGIPDYRSEGVGLYARTSRRPMQHAEFARSAVARRRYWARNFTGWPRFS---------SRRPNAAHLALGRWEQQGRLHWLVTQNVDALHAKAG--SRRITELHGCSHRVVCLDCKEVTQRTELQQRMLDMNPGWQQQHEQAIAPDGDVLLSDSQVESFRVPPCRSCGGPLKPEVTFFGDNVDRRTVDDVYQRLESDTVLVAGSSLQV 261

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Match: HST2 (Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export [Source:SGD;Acc:S000005936])

HSP 1 Score: 227.254 bits (578), Expect = 4.929e-70
Identity = 122/300 (40.67%), Postives = 175/300 (58.33%), Query Frame = 1

Query:  532 IVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEI---CYCSKCRGIVKPDIVFFGEDLPSKF-HLFRSDFQ-------------QADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKE----GEENQINFFNTISKIKRNSIPNSRNYST 1368
            ++ M GAGIS   GIPDFRSPGTGLY NL + K+PYPEA+FD+D+F  +P PF+ LAKEL+P G +RP+K HY  +L Q+K +L+RVYTQNID LER AG+ D  ++EAHG+FA   C+ CG+ Y     K  + +  I     C  C  +VKP IVFFGEDLP  F   + +D +             Q  L++V+GTSL V PFAS+ +       RVL N + VG F++ +R  D  V     +  + L + L W+ + +K++      G+ ++      +  ++  S+  S + S 
Sbjct:   27 VIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYP-GNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESA 325

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Match: HST1 (NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication [Source:SGD;Acc:S000005429])

HSP 1 Score: 169.474 bits (428), Expect = 8.075e-47
Identity = 99/277 (35.74%), Postives = 144/277 (51.99%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFP-SGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKC------------------------------RGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEI 1260
            K I+++ GAG+S   GIPDFRS   G Y  ++   +  P+ +F++D FLQ+P  F+ +A  + P    Y P  +H F ++LQ+K  L R YTQNID LE  AG++   LV+ HG+FA+ASCV C       ++ E+I   E+  C  C                               G++KPD+ FFGE LPS+FH   R D  + DLL+ +GTSL+V P + IV+      P++LINR  V          D  +LG   D   +++K   W+I
Sbjct:  201 KKILVLTGAGVSTSLGIPDFRS-SEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSP--LHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVT-----HAEFDLNLLGFCDDVASLVAKKCHWDI 469

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Match: SIR2 (Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200])

HSP 1 Score: 164.466 bits (415), Expect = 1.189e-44
Identity = 103/297 (34.68%), Postives = 150/297 (50.51%), Query Frame = 1

Query:  484 FIVD-ICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGK-YRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKC-----------------------------------RGIVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEI 1260
            F +D   QK+ T++   I+++ GAG+S   GIPDFRS   G Y  +K   +  P+ +F+ + F+ +P  F+ +A  + P  K Y P  +H F ++LQ K  L R YTQNID LE  AG++   LV+ HG+FA+A+CV C  +    ++   I   E+  C  C                                    G++KPDI FFGE LP+KFH   R D  + DLL+ +GTSL+V P + IV+      P+VLINR PV     K    D  +LG   D   ++++   W I
Sbjct:  242 FTIDHFIQKLHTAR--KILVLTGAGVSTSLGIPDFRS-SEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSP--LHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPV-----KHAEFDLSLLGYCDDIAAMVAQKCGWTI 528

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Match: HST3 (Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000005551])

HSP 1 Score: 105.916 bits (263), Expect = 4.836e-25
Identity = 80/269 (29.74%), Postives = 126/269 (46.84%), Query Frame = 1

Query:  517 SKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQ-----YKIPYPEAIFDIDYFLQNPKP--FFALAKELFPSGKY-RPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTN----------------LVEAHGTFASASCVRCGEDYSATQ-LKESIDKSEICYCSKCR------------------GIVKPDIVFFGEDLPSKFHLFRS---DFQQA--DLLLVMGTSLEVEPFASIVDSTR-----FGTPRVLINRQPVG 1164
            S+ + I  + GAGISC +GIPDFRS   GLYD +K+     + I     +FDI  F  + K   F    + L+ + +  +P K H F   L+++  L R YTQNIDGLE   GL  +N                +V+ HG   + SC +C + +  ++     + + E+  C  C                   GI++P+IV +GE+ PS   + +    D  +   D L++MGTSL+V+    +V          G   +L+N+ P+G
Sbjct:   50 SRSRRIACLTGAGISCNAGIPDFRS-SDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIG 317

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Match: HST4 (NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3 [Source:SGD;Acc:S000002599])

HSP 1 Score: 56.6102 bits (135), Expect = 3.958e-9
Identity = 74/280 (26.43%), Postives = 115/280 (41.07%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSP---------GTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNL---------VEAHGTFASASCVRCGE----DYSATQLKESID-KSEIC-YCSKCR----------------GIVKPDIVFFGEDLPSK---FHLFRSDFQQ-ADLLLVMGTSLEV-------EPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGD 1212
            K +V+++GAGIS  +GIPDFRS          G+G   +L  Y   Y +    +  F Q     F L+K        +P K H           L R+YTQNIDGL+       TN+         V+ HG+     C +C      D    +  +  D ++EI   C +C                 G ++P ++ + E  P       +  +D ++  D L+++GTSL++         FA+ V + R     +  +  P  V  S + V D  VLGD
Sbjct:   93 KRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSG--KDLFDYNRVYGDESMSLK-FNQLMVSLFRLSKNC------QPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFV-DLVVLGD 362

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Match: EDO47672 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLD5])

HSP 1 Score: 306.605 bits (784), Expect = 2.035e-100
Identity = 146/255 (57.25%), Postives = 187/255 (73.33%), Query Frame = 1

Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCS--KCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRS--KRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEE 1293
            MAGAGIS PSGIPDFR+PGTGLYDNL++Y IP P AIFDI+YF  +P+PFF LAK L+P G Y+PN VHYF +LL +K  L R+YTQNIDGLERLAGL    LVEAHGTF++ASC+ C   Y   Q++++I+  +I  C   KC+G++KPD+VFFGEDLP +F+ F  DF++ DLLLVMGTSLEVEPFA IV+     TPRVLINR+ VG F    +RR  D  + GDI+  +  L+K L W   +D +++  ++
Sbjct:    1 MAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFCLAKTLYP-GNYQPNYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCISCHHSYDGEQIRKTIENGDIPRCETIKCKGVIKPDVVFFGEDLPKRFYSFEIDFRKCDLLLVMGTSLEVEPFAGIVNEVSRSTPRVLINRESVGPFLHPWRRRPKDVVLKGDIVSSVKRLAKLLEWTDSMDNIIETADK 254

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Match: EDO46813 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNW2])

HSP 1 Score: 253.062 bits (645), Expect = 4.621e-80
Identity = 130/271 (47.97%), Postives = 177/271 (65.31%), Query Frame = 1

Query:  496 ICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVG----------------VFRSKRRVHDNCVLGDIIDGIDVLSKNLRWE 1257
            +   I + K K+I++M GAGIS  +GIPDFRSPGTGLYDNL++Y +PYPE+IF+I YF  NP+PFFAL KEL+P G ++P   HYF +LL +KKLL R YTQN+D LER+AG+ D  LVEAHG+F +A C+ C ++Y+   +++ I   ++  CS C G++KPDIVFFGE LP +FH L   D    DL+++MGTSL V+PFAS++D     TPR+LIN++  G                 F  +    D   LG   DG   L++ L W+
Sbjct:   33 VANYIKSGKCKHIIVMTGAGISTAAGIPDFRSPGTGLYDNLQKYNLPYPESIFEIGYFRSNPEPFFALCKELYP-GSFKPTMSHYFIKLLYDKKLLLRNYTQNVDTLERIAGVPDDLLVEAHGSFHTAHCIECKKEYTKEDVRDEIFADKVPRCSGCEGVIKPDIVFFGESLPGRFHRLVPQDMPHCDLIIIMGTSLAVQPFASLIDRVLATTPRLLINKEKCGRQASFLSFLSGVDSGFKFDKEDNYRDVAWLGTTDDGCLALAELLGWK 302

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Match: EDO48459 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIU3])

HSP 1 Score: 243.047 bits (619), Expect = 1.683e-76
Identity = 126/274 (45.99%), Postives = 173/274 (63.14%), Query Frame = 1

Query:  472 DDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFH-LFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV----------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEI 1260
            DD  F   I + I + K KNIV++ GAGIS  +GIPDFR+PG+GL++ L+ Y +    +IF+IDYF  NPKPFF  AK ++P G+++P   HYF +LLQ K LL R YTQNID LER+AG+   +L+EAHG+F +  C+ C ++YS   ++  I   +I  C++C G+VKPDI FFG+ +P KF+ L   DF + DLL+VMGTSL V+PFAS++      TPR+LINR+  G           F  K    D   LG   DG   L+  L W++
Sbjct:    2 DDVSF-EGIARYITSGKCKNIVVLTGAGISTTAGIPDFRTPGSGLFNVLQTYGLTTARSIFEIDYFQMNPKPFFVAAKAVYP-GQFKPTISHYFIKLLQNKGLLLRHYTQNIDTLERVAGITGDHLMEAHGSFHTGHCMACNKEYSQDWIRVEIMADKIPRCTECDGVVKPDIGFFGDPMPDKFYQLAAEDFPKCDLLIVMGTSLIVQPFASLIARVSVDTPRLLINREKCGYEVHGPRPGFQFELKDNKRDVAWLGTTDDGCLALAALLGWKV 273

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Match: EDO31684 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX90])

HSP 1 Score: 193.356 bits (490), Expect = 2.883e-57
Identity = 109/243 (44.86%), Postives = 151/243 (62.14%), Query Frame = 1

Query:  511 LTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLK-QY-KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCR------GIVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGD 1212
            L  K KNI+++ GAG+S   GIPDFRS   G+Y  L  +Y  +P P+A+FDI YF QNPKPFF  AKE++P G+++P+  H F   L+E   L R Y+QNID LE++AG+  T +++ HG+F++ASC+RC        +KE I +  I  CS C        I+KPDIVFFGE LPS F+     D  +ADLL+V+G+SL+V P A I        P++LINR+P+     +    D  +LGD
Sbjct:   65 LIKKCKNIIVLTGAGVSVSCGIPDFRS-RDGIYAKLSVEYPDLPDPQAMFDITYFNQNPKPFFKFAKEIYP-GQFKPSLCHRFIHQLEEHGHLLRNYSQNIDTLEQVAGI--TRVIQCHGSFSTASCMRCKHKVPCEAIKEDIFRKNIPVCSTCSPDEEFPSIMKPDIVFFGESLPSNFYTHLGDDSNKADLLIVIGSSLKVRPVALIPSHISPEVPQILINREPL-----RHMTFDVELLGD 298

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Match: EDO35866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK95])

HSP 1 Score: 92.8189 bits (229), Expect = 1.001e-20
Identity = 71/274 (25.91%), Postives = 126/274 (45.99%), Query Frame = 1

Query:  532 IVIMAGAGISCPSGIPDFRSPGTGLY----DNLKQYKIPYPEAIFDIDYFLQN--PKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLK---------------------------ESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSD-FQQADLLLVMGTSLEV-EPFASIVDSTRFGTPRVLINRQPVGVFRSKR--RVHDNCVLGDIIDGIDVLSK 1242
            I ++ GAGIS  SGI D+RS G GLY    D   +Y++    A+    Y+ +N    P F         G  +PN+ HY    L+    +  + TQN+D L   AG    N++E HG      C+ C +  + T L+                           E++   ++  C  C GI+KP++VFFG+ +P +      D   ++D L ++G+++EV   +    ++++ G P  ++N   +G  R+ +   +  + V G ++  +D+L +
Sbjct:   63 IFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARNYVGWPEF---------GSRQPNEAHYALAKLETLGSVHSLVTQNVDALHTKAG--SKNVIELHGCSHRVICLGCNQITARTALQKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILN---IGKTRADKLASLKVSGVCGTVLPKLDLLQR 322

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Match: sirt3 (sirtuin 3 [Source:NCBI gene;Acc:101161471])

HSP 1 Score: 320.087 bits (819), Expect = 3.008e-105
Identity = 151/273 (55.31%), Postives = 190/273 (69.60%), Query Frame = 1

Query:  478 QKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            Q  + DI + +   + K +V+MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I +F +NP PFFALAKEL+P G YRPN  H+F  LL +K  L R+YTQNIDGLERLAG+    LVEAHGTFA+A+C  C + Y   +L+ ++    +  CS C G+VKPDIVFFGE+LP  F  + +DF  ADLL++MGTSLEVEPFAS+  + R   PR+LINR PVG F   RR  D   LG+++ G+  L + L W  EL  LM  G E 
Sbjct:   65 QLTLQDIARSLRDRQHKRVVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYDLPYAEAIFEIGFFHRNPAPFFALAKELYP-GNYRPNPTHFFVHLLHQKGQLLRMYTQNIDGLERLAGIPPEKLVEAHGTFATATCTSCLQKYKGEELRPAVMSGSVPKCSACGGVVKPDIVFFGEELPPHFLKYLTDFPLADLLIIMGTSLEVEPFASLAGAVRSSVPRLLINRDPVGPFVWGRRPQDVLQLGEVMGGVQALVEALGWTRELQALMAAGVEQ 336

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Match: sirt3 (sirtuin 3 [Source:NCBI gene;Acc:101161471])

HSP 1 Score: 309.686 bits (792), Expect = 3.876e-102
Identity = 145/252 (57.54%), Postives = 180/252 (71.43%), Query Frame = 1

Query:  541 MAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEEN 1296
            MAGAGIS PSGIPDFRSPG+GLYDNL+QY +PY EAIF+I +F +NP PFFALAKEL+P G YRPN  H+F  LL +K  L R+YTQNIDGLERLAG+    LVEAHGTFA+A+C  C + Y   +L+ ++    +  CS C G+VKPDIVFFGE+LP  F  + +DF  ADLL++MGTSLEVEPFAS+  + R   PR+LINR PVG F   RR  D   LG+++ G+  L + L W  EL  LM  G+ +
Sbjct:    1 MAGAGISTPSGIPDFRSPGSGLYDNLQQYDLPYAEAIFEIGFFHRNPAPFFALAKELYP-GNYRPNPTHFFVHLLHQKGQLLRMYTQNIDGLERLAGIPPEKLVEAHGTFATATCTSCLQKYKGEELRPAVMSGSVPKCSACGGVVKPDIVFFGEELPPHFLKYLTDFPLADLLIIMGTSLEVEPFASLAGAVRSSVPRLLINRDPVGPFVWGRRPQDVLQLGEVMGGVQALVEALGWTRELQALMAAGKTD 251

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Match: si:dkey-103i16.6 (NAD-dependent protein deacetylase sirtuin-3, mitochondrial [Source:NCBI gene;Acc:101165477])

HSP 1 Score: 309.301 bits (791), Expect = 6.315e-100
Identity = 145/272 (53.31%), Postives = 195/272 (71.69%), Query Frame = 1

Query:  487 IVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVF-RSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQ 1299
            ++ + + +   + KN+V++AGAGIS  SGIPDFR+PGTGLY NL++Y +PYPEAIF+IDYF  NP+PFF+LAK L+P G +RPN +HYF R+L  K LL R+YTQNIDGLE+L G+ D  LVEAHG+FA+ASC  C   Y A + + +I    +  CS C   VKPD+VFFGEDLP K+ L R DF +ADLL++MGTSL++EPFAS+V+S R   PR+L+NR  VG F R   R  D+  LGD+ D +   ++ L W+ E+ +LM+  E N+
Sbjct:  107 LLSVARLVKLGRCKNVVVVAGAGISTASGIPDFRTPGTGLYSNLEKYNVPYPEAIFNIDYFSDNPQPFFSLAKVLYP-GSHRPNYIHYFIRVLHHKGLLLRMYTQNIDGLEKLCGIPDDKLVEAHGSFATASCHLCYTPYPAEEARYAIMHDRVPTCSFCTATVKPDVVFFGEDLPRKYFLHRKDFPKADLLIIMGTSLKIEPFASLVNSVRSTVPRLLLNRNAVGPFERVPLRRGDHMELGDLADSVRKFAEMLGWDGEIQELMRSQEVNR 377

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BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Match: sirt2 (sirtuin 2 [Source:NCBI gene;Acc:101155450])

HSP 1 Score: 269.24 bits (687), Expect = 5.716e-85
Identity = 146/309 (47.25%), Postives = 192/309 (62.14%), Query Frame = 1

Query:  433 STFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGV---------------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQIN 1305
            ST G  L +     D   +  + Q I + K KNI+ M GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF IDYF ++P+PFF LAKEL+P G+++P   HYF +LL+ K LLRR YTQNID LER+AGL   +L+EAHGTF ++ CV   C ++YS   +KE I    I  C KC  +VKPDIVFFGE+LP++F    + DF + DLL+VMGTSL+V+PFA +V       PR+LIN +  G                F S +   D   +    DG   L+  L W+ EL+ L+K+ E  QI+
Sbjct:   47 STLG--LGSAEKVLDALTLEGVAQYIKSGKCKNIICMVGAGISTSAGIPDFRSPETGLYANLQKYNLPYPEAIFQIDYFKKHPEPFFTLAKELYP-GQFKPTICHYFIKLLKNKGLLRRCYTQNIDTLERVAGLEKEDLIEAHGTFYTSHCVSFCCRKEYSLDWMKEKIFSDAIPKCEKCNSLVKPDIVFFGENLPARFFTSVKMDFPRCDLLIVMGTSLQVQPFAGLVGRVSKSCPRLLINMEKAGEADPMLGMLGFGGGMDFDSDKAYRDVAHISSCDDGCLALADLLGWKAELEALVKQ-EHAQID 351

[Close]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Match: sirt2 (sirtuin 2 [Source:NCBI gene;Acc:101155450])

HSP 1 Score: 257.684 bits (657), Expect = 1.249e-80
Identity = 146/320 (45.62%), Postives = 191/320 (59.69%), Query Frame = 1

Query:  433 STFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVR--CGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDS------------------TRFGTPRVLINRQPVGV---------FRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQIN 1305
            ST G  L +     D   +  + Q I + K KNI+ M GAGIS  +GIPDFRSP TGLY NL++Y +PYPEAIF IDYF ++P+PFF LAKEL+P G+++P   HYF +LL+ K LLRR YTQNID LER+AGL   +L+EAHGTF ++ CV   C ++YS   +KE I    I  C KC  +VKPDIVFFGE+LP++F  F SDF + DLL+VMGTSL+V+PFA +V                     RF   + L    P+           F S +   D   +    DG   L+  L W+ EL+ L+K+ E  QI+
Sbjct:   31 STLG--LGSAEKVLDALTLEGVAQYIKSGKCKNIICMVGAGISTSAGIPDFRSPETGLYANLQKYNLPYPEAIFQIDYFKKHPEPFFTLAKELYP-GQFKPTICHYFIKLLKNKGLLRRCYTQNIDTLERVAGLEKEDLIEAHGTFYTSHCVSFCCRKEYSLDWMKEKIFSDAIPKCEKCNSLVKPDIVFFGENLPARF--FTSDFPRCDLLIVMGTSLQVQPFAGLVGRYGVRPAGSPPHKTHRKLWIRFKKKKTLFFADPMLGMLGFGGGMDFDSDKAYRDVAHISSCDDGCLALADLLGWKAELEALVKQ-EHAQID 344

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BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Match: SMESG000079803.1 (SMESG000079803.1)

HSP 1 Score: 932.554 bits (2409), Expect = 0.000e+0
Identity = 453/453 (100.00%), Postives = 453/453 (100.00%), Query Frame = 1

Query:   61 MVISSKNIIKLFSLINMMNKSNSKPPINLLSRLKIVHSFSAQSTKNLNPFDQKSNPSSQYSNGKVEQSENNLHNIPRQTALNGKLLFRENTSIASNKIEKSKLPSRNNDRVSSTSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNTISKIKRNSIPNSRNYSTFANTTRCRPWILPPLQR 1419
            MVISSKNIIKLFSLINMMNKSNSKPPINLLSRLKIVHSFSAQSTKNLNPFDQKSNPSSQYSNGKVEQSENNLHNIPRQTALNGKLLFRENTSIASNKIEKSKLPSRNNDRVSSTSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNTISKIKRNSIPNSRNYSTFANTTRCRPWILPPLQR
Sbjct:    1 MVISSKNIIKLFSLINMMNKSNSKPPINLLSRLKIVHSFSAQSTKNLNPFDQKSNPSSQYSNGKVEQSENNLHNIPRQTALNGKLLFRENTSIASNKIEKSKLPSRNNDRVSSTSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKLMKEGEENQINFFNTISKIKRNSIPNSRNYSTFANTTRCRPWILPPLQR 453

[Close]

BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 176.407 bits (446), Expect = 1.999e-48
Identity = 102/271 (37.64%), Postives = 150/271 (55.35%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRG------------------------IVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWE 1257
            KNI+++ GAGIS P G+PDFRS   G+Y  L      +  P+++FDI YF +NPKPFF  AKE++P GK+ P+  H F ++L++K  L R Y+QNID LE++AG+   N++  HG+FASA+C+RC        ++  +   +I  C  C                          I+KPD+VFFGE LP  FH     D  Q DLL+V+G+SL+V P A I        P++LIN++ +          D  +LGD  + +  + K L+W+
Sbjct:  107 KNIMVLTGAGISVPCGVPDFRS-RNGIYARLAVDFPDLDEPQSMFDIHYFSKNPKPFFKFAKEIYP-GKFTPSFGHRFIKVLEDKGKLLRNYSQNIDTLEQIAGIK--NIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERNQENLLSSIGNSDEVDTNIPIMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKVRPVAHIPGCLPPNIPQILINKETL-----VSHGFDIELLGDCDNIVTEICKQLQWD 368

[Close]

BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 176.022 bits (445), Expect = 2.567e-48
Identity = 102/271 (37.64%), Postives = 150/271 (55.35%), Query Frame = 1

Query:  526 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQY--KIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCSKCRG------------------------IVKPDIVFFGEDLPSKFHL-FRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWE 1257
            KNI+++ GAGIS P G+PDFRS   G+Y  L      +  P+++FDI YF +NPKPFF  AKE++P GK+ P+  H F ++L++K  L R Y+QNID LE++AG+   N++  HG+FASA+C+RC        ++  +   +I  C  C                          I+KPD+VFFGE LP  FH     D  Q DLL+V+G+SL+V P A I        P++LIN++ +          D  +LGD  + +  + K L+W+
Sbjct:   98 KNIMVLTGAGISVPCGVPDFRS-RNGIYARLAVDFPDLDEPQSMFDIHYFSKNPKPFFKFAKEIYP-GKFTPSFGHRFIKVLEDKGKLLRNYSQNIDTLEQIAGIK--NIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERNQENLLSSIGNSDEVDTNIPIMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKVRPVAHIPGCLPPNIPQILINKETL-----VSHGFDIELLGDCDNIVTEICKQLQWD 359

[Close]

BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Match: SMESG000062887.1 (SMESG000062887.1)

HSP 1 Score: 163.696 bits (413), Expect = 6.337e-46
Identity = 107/267 (40.07%), Postives = 153/267 (57.30%), Query Frame = 1

Query:  487 IVDICQKILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLK-QYKIPYPEAIFDIDYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEI--CYCSKCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLI-NRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEIELDKL 1275
            ++DI + I +++ K IV   GAGIS  +GIPDFRS   GLY+ +K +  +P PE IFDI YF  +P  F  +AK+ F    Y P   H F +LL  KKLL R +TQNIDGL+   G+ D   +E HG F +  C+ C + YS  ++K  ++ ++   C    C G+VKPDIV FGE LP K     +   +ADL++VMG+SL V PF   ++  R  TP ++I N QP G      + +   +  D  DGI  +   L W+ EL+++
Sbjct:   30 LIDIIEIIRSNESK-IVTFTGAGISTSAGIPDFRSE-NGLYNIVKSKLNMPNPELIFDISYFEIDPTMFCCIAKQ-FIQNDYYPTLTHCFLKLLHNKKLLLRNFTQNIDGLDSKVGIPDDINIECHGHFKTGHCLSCEKLYSYEEMKSQLESNDFIKCQAENCNGLVKPDIVLFGESLPKKVFENLNKISKADLIIVMGSSLRVTPFNQFINLARKETPLLVINNEQPSGGILLSSKKYFLQLPCD--DGIKKICDLLHWQSELEEI 291

[Close]

BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Match: SMESG000074693.1 (SMESG000074693.1)

HSP 1 Score: 88.5817 bits (218), Expect = 3.342e-19
Identity = 71/231 (30.74%), Postives = 111/231 (48.05%), Query Frame = 1

Query:  505 KILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFL---QNPKPFFA---LAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKE-----------SIDKSEIC------------------YCSKCRGIVKPDIVFFGEDLPS-KFHLFRSDFQQADLLLVMGTSLEV 1089
            K ++S+ K ++++ GAG+S  SGIPD+RS   GLY +     + Y         FL   +N + ++A       LF S   RPN  H      +++  +    +QN+D L + +GL    LVE HG      C+ C    S  +L+E            ID+++I                    C KC+GI+KPDI+FFG+++P+    L ++    +D LL +GTSLEV
Sbjct:   20 KFISSRGK-LLVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEY-------QVFLRSHENRQRYWARNYFGWPLFSS--IRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLVELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 238

The following BLAST results are available for this feature:

BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
BLAST of NAD-dependent protein deacetylase vs. Ensembl Celegans
BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
BLAST of NAD-dependent protein deacetylase vs. TrEMBL
BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST

BLAST of NAD-dependent protein deacetylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SIRT3	3.501e-97	51.58	sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931]	[more]
SIRT3	5.478e-96	53.23	sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931]	[more]
SIRT3	5.037e-95	55.47	sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931]	[more]
SIRT2	2.676e-85	46.88	sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886]	[more]
SIRT2	2.676e-85	46.88	sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886]	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sir-2.1	5.259e-53	40.51	NAD-dependent protein deacetylase sir-2.1 [Source...	[more]
sir-2.1	5.259e-53	40.51	NAD-dependent protein deacetylase sir-2.1 [Source...	[more]
sir-2.1	5.259e-53	40.51	NAD-dependent protein deacetylase sir-2.1 [Source...	[more]
sir-2.1	8.124e-53	40.51	NAD-dependent protein deacetylase sir-2.1 [Source...	[more]
sir-2.1	8.124e-53	40.51	NAD-dependent protein deacetylase sir-2.1 [Source...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Sirt2	2.393e-83	49.63	gene:FBgn0038788 transcript:FBtr0083882	[more]
Sirt2	2.393e-83	49.63	gene:FBgn0038788 transcript:FBtr0344243	[more]
Sirt1	2.358e-48	39.67	gene:FBgn0024291 transcript:FBtr0080434	[more]
Sirt6	7.669e-17	26.40	gene:FBgn0037802 transcript:FBtr0305358	[more]
Sirt4	1.028e-15	28.51	gene:FBgn0029783 transcript:FBtr0070852	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sirt3	4.430e-106	57.14	sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762]	[more]
sirt3	5.043e-106	57.14	sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762]	[more]
sirt3	1.870e-101	58.33	sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762]	[more]
si:dkey-103i16.6	1.329e-99	49.83	si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-...	[more]
si:dkey-103i16.6	3.293e-98	47.76	si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoga1	1.563e-99	48.31	4-hydroxy-2-oxoglutarate aldolase 1 [Source:Xenbas...	[more]
SIRT2	1.704e-92	51.35	sirtuin 2 [Source:NCBI gene;Acc:100489469]	[more]
SIRT3	1.218e-91	49.12	sirtuin 3 [Source:NCBI gene;Acc:100487410]	[more]
SIRT3	5.256e-91	49.12	sirtuin 3 [Source:NCBI gene;Acc:100487410]	[more]
SIRT2	1.424e-84	52.38	sirtuin 2 [Source:NCBI gene;Acc:100489469]	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Sirt3	5.929e-95	56.28	sirtuin 3 [Source:MGI Symbol;Acc:MGI:1927665]	[more]
Sirt3	5.929e-95	56.28	sirtuin 3 [Source:MGI Symbol;Acc:MGI:1927665]	[more]
Sirt2	1.650e-86	46.42	sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664]	[more]
Sirt2	2.987e-86	48.91	sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664]	[more]
Sirt2	4.444e-86	46.42	sirtuin 2 [Source:MGI Symbol;Acc:MGI:1927664]	[more]

BLAST of NAD-dependent protein deacetylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8R104\|SIR3_MOUSE	2.210e-96	53.33	NAD-dependent protein deacetylase sirtuin-3 OS=Mus...	[more]
sp\|Q9NTG7\|SIR3_HUMAN	2.631e-95	53.23	NAD-dependent protein deacetylase sirtuin-3, mitoc...	[more]
sp\|Q7ZVK3\|SIR2_DANRE	2.883e-87	45.26	NAD-dependent protein deacetylase sirtuin-2 OS=Dan...	[more]
sp\|Q5RJQ4\|SIR2_RAT	1.562e-85	46.76	NAD-dependent protein deacetylase sirtuin-2 OS=Rat...	[more]
sp\|Q8VDQ8\|SIR2_MOUSE	3.109e-85	46.42	NAD-dependent protein deacetylase sirtuin-2 OS=Mus...	[more]

BLAST of NAD-dependent protein deacetylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3JTY3	3.594e-114	61.71	NAD-dependent protein deacetylase sirtuin-3 OS=Lin...	[more]
C3Z1Z2	8.316e-109	61.57	Deacetylase sirtuin-type domain-containing protein...	[more]
H2ZB27	3.875e-107	60.07	NAD-dependent protein deacetylase OS=Ciona savigny...	[more]
A0A3B4Z9K6	1.292e-106	50.92	NAD-dependent protein deacetylase OS=Stegastes par...	[more]
A0A068WY32	4.356e-106	53.54	NAD dependent deacetylase sirtuin 3 OS=Echinococcu...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sirt3	1.081e-101	57.03	sirtuin 3 [Source:NCBI gene;Acc:103044645]	[more]
si:dkey-103i16.6	8.326e-96	52.71	si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-...	[more]
si:dkey-103i16.6	1.383e-93	52.94	si:dkey-103i16.6 [Source:ZFIN;Acc:ZDB-GENE-061207-...	[more]
sirt2	8.125e-85	48.21	sirtuin 2 [Source:NCBI gene;Acc:103038996]	[more]
ENSAMXT00000003809.2	6.515e-52	44.75	pep primary_assembly:Astyanax_mexicanus-2.0:25:451...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
sirt3	2.344e-94	54.37	sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762]	[more]
sirt2	1.710e-88	50.36	sirtuin 2 (silent mating type information regulati...	[more]
sirt6	1.135e-17	28.83	sirtuin 6 [Source:ZFIN;Acc:ZDB-GENE-031007-2]	[more]
sirt4	1.082e-16	25.10	sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65]	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
HST2	4.929e-70	40.67	Cytoplasmic NAD(+)-dependent protein deacetylase; ...	[more]
HST1	8.075e-47	35.74	NAD(+)-dependent histone deacetylase; essential su...	[more]
SIR2	1.189e-44	34.68	Conserved NAD+ dependent histone deacetylase of th...	[more]
HST3	4.836e-25	29.74	Member of the Sir2 family of NAD(+)-dependent prot...	[more]
HST4	3.958e-9	26.43	NAD(+)-dependent protein deacetylase; deacetylatio...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47672	2.035e-100	57.25	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46813	4.621e-80	47.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48459	1.683e-76	45.99	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31684	2.883e-57	44.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35866	1.001e-20	25.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of NAD-dependent protein deacetylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sirt3	3.008e-105	55.31	sirtuin 3 [Source:NCBI gene;Acc:101161471]	[more]
sirt3	3.876e-102	57.54	sirtuin 3 [Source:NCBI gene;Acc:101161471]	[more]
si:dkey-103i16.6	6.315e-100	53.31	NAD-dependent protein deacetylase sirtuin-3, mitoc...	[more]
sirt2	5.716e-85	47.25	sirtuin 2 [Source:NCBI gene;Acc:101155450]	[more]
sirt2	1.249e-80	45.63	sirtuin 2 [Source:NCBI gene;Acc:101155450]	[more]

BLAST of NAD-dependent protein deacetylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000079803.1	0.000e+0	100.00	SMESG000079803.1	[more]
SMESG000079103.1	1.999e-48	37.64	SMESG000079103.1	[more]
SMESG000079103.1	2.567e-48	37.64	SMESG000079103.1	[more]
SMESG000062887.1	6.337e-46	40.07	SMESG000062887.1	[more]
SMESG000074693.1	3.342e-19	30.74	SMESG000074693.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30005908 ID=SMED30005908|Name=NAD-dependent protein deacetylase|organism=Schmidtea mediterranea sexual|type=transcript|length=1647bp
ATAATTTAATTAATTAATTAATTACTAATAAATTACATTATATAAGATAT
GTAATGAATAATGGTAATTTCAAGTAAAAATATTATAAAACTATTCAGCT
TAATTAATATGATGAATAAGTCTAATTCAAAACCACCAATAAATCTTTTG
AGCCGATTGAAAATCGTTCATTCATTTTCAGCTCAATCCACAAAAAATTT
AAATCCTTTTGATCAAAAGTCAAATCCTTCTAGTCAATATTCAAATGGAA
AAGTTGAACAATCTGAAAATAATTTACATAACATTCCTCGCCAAACTGCA
CTGAATGGCAAGTTACTTTTCCGAGAAAATACTTCAATTGCTTCAAATAA
AATTGAAAAATCTAAACTTCCTTCAAGAAATAATGATCGGGTGTCTTCTA
CTTCTGTAAATAAAAACACCTCTCGGCCTTTCAGCACATTTGGCAGATAT
CTTTCTACTCCGTCTGGTACAGATGATCAGAAATTTATTGTAGACATATG
CCAAAAGATTCTGACGTCAAAAATAAAAAACATTGTCATTATGGCCGGAG
CTGGCATAAGTTGTCCGAGTGGAATTCCTGATTTCAGAAGCCCGGGAACT
GGACTATATGACAATCTCAAGCAATATAAAATACCTTATCCAGAAGCAAT
TTTTGATATTGACTATTTTCTTCAAAATCCAAAACCATTCTTTGCTCTGG
CAAAAGAATTATTTCCATCAGGAAAATACAGACCAAATAAAGTGCACTAC
TTTTTCCGACTTTTACAGGAAAAGAAATTATTGCGCAGGGTTTATACTCA
AAACATCGACGGACTTGAAAGATTAGCCGGACTGAATGATACAAACCTTG
TTGAAGCTCATGGAACATTTGCATCTGCTAGCTGTGTTCGTTGTGGTGAA
GATTATTCGGCAACACAATTAAAAGAAAGTATCGATAAAAGTGAAATTTG
TTATTGCTCAAAATGTCGAGGAATCGTTAAACCTGATATCGTTTTCTTTG
GCGAAGACCTTCCATCTAAATTCCATCTGTTTAGAAGTGATTTTCAACAA
GCCGATTTATTATTGGTTATGGGCACATCTTTAGAAGTGGAACCATTTGC
TAGTATCGTAGACTCTACCAGATTCGGCACTCCTCGAGTTTTAATCAACA
GGCAACCTGTTGGCGTTTTTCGTTCCAAACGACGAGTGCATGATAATTGT
GTTTTAGGTGACATCATTGACGGAATAGATGTTTTATCGAAAAACCTACG
TTGGGAAATAGAATTAGATAAATTAATGAAAGAAGGTGAAGAGAATCAAA
TAAATTTTTTCAATACTATTTCAAAGATCAAGCGAAATTCAATTCCAAAT
TCAAGAAACTATAGCACGTTTGCAAATACTACACGTTGTCGACCTTGGAT
ACTTCCTCCGTTGCAGAGAAATTCTAATAAAGGCAAAAATAAATACAATA
AAACGAATTCTTCTTCATCCGATGAAGAAAGTGAAGATTCTTCAAGCTGT
GAATCAGATAGCTCATAAAATATTTAATTCCCTGTACAGTTTCTAAATCT
TTATTTCACAAATTCGTGATTGATTTTAATAAATATTCTGATAAATTCTA
AATATTTTGATCGATCAAATACATGACAATTGAGCAATTAAAAACAA

protein sequence of SMED30005908-orf-1

>SMED30005908-orf-1 ID=SMED30005908-orf-1|Name=SMED30005908-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=486bp
MVISSKNIIKLFSLINMMNKSNSKPPINLLSRLKIVHSFSAQSTKNLNPF
DQKSNPSSQYSNGKVEQSENNLHNIPRQTALNGKLLFRENTSIASNKIEK
SKLPSRNNDRVSSTSVNKNTSRPFSTFGRYLSTPSGTDDQKFIVDICQKI
LTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDI
DYFLQNPKPFFALAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNID
GLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKESIDKSEICYCS
KCRGIVKPDIVFFGEDLPSKFHLFRSDFQQADLLLVMGTSLEVEPFASIV
DSTRFGTPRVLINRQPVGVFRSKRRVHDNCVLGDIIDGIDVLSKNLRWEI
ELDKLMKEGEENQINFFNTISKIKRNSIPNSRNYSTFANTTRCRPWILPP
LQRNSNKGKNKYNKTNSSSSDEESEDSSSCESDSS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0017136	NAD-dependent histone deacetylase activity
GO:0046872	metal ion binding
GO:0070403	NAD+ binding

Vocabulary: **biological process**
Term	Definition
GO:0016575	histone deacetylation

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR017328	Sirtuin_class_I
IPR003000	Sirtuin
IPR029035	DHS-like_NAD/FAD-binding_dom
IPR026591	Sirtuin_cat_small_dom_sf
IPR026590	Ssirtuin_cat_dom

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR026591	Sirtuin, catalytic core small domain superfamily	GENE3D	G3DSA:3.30.1600.10		coord: 169..320 e-value: 3.5E-106 score: 356.1
IPR017328	Sirtuin, class I	PIRSF	PIRSF037938	SIR2_euk	coord: 129..485 e-value: 3.0E-120 score: 399.0
IPR003000	Sirtuin family	PFAM	PF02146	SIR2	coord: 163..345 e-value: 1.2E-56 score: 191.5
None	No IPR available	GENE3D	G3DSA:3.40.50.1220		coord: 146..405 e-value: 3.5E-106 score: 356.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 46..74
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 97..118
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 448..485
None	No IPR available	PANTHER	PTHR11085:SF38		coord: 127..411
None	No IPR available	PANTHER	PTHR11085	HISTONE DEACETYLASE SIR2 FAMILY MEMBER	coord: 127..411
None	No IPR available	CDD	cd01408	SIRT1	coord: 156..392 e-value: 3.11533E-123 score: 357.326
IPR026590	Sirtuin family, catalytic core domain	PROSITE	PS50305	SIRTUIN	coord: 144..401 score: 47.293
IPR029035	DHS-like NAD/FAD-binding domain superfamily	SUPERFAMILY	SSF52467	DHS-like NAD/FAD-binding domain	coord: 145..408