DUF4476 domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30005870 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Match: A0A3R7DG61 (DUF4476 domain-containing protein OS=Clonorchis sinensis OX=79923 GN=CSKR_6925s PE=4 SV=1) HSP 1 Score: 228.409 bits (581), Expect = 9.427e-70 Identity = 113/207 (54.59%), Postives = 146/207 (70.53%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYD 759 MAK P +S F L+ L ET +KKF +YY +G FSG QAA LL FKTAPE+++VI++L++RLCRM CAE +EIL +Q NNDRL ALN +KRTL+DH+ TEG+E+ILSAFPF++DK KAL IL TVS + QL SGGHQ YAP GGLY+Q+FP +E L+G LEDQ+ P++P+ A PS + + PSY Y+ Sbjct: 1 MAKVPLSDSDFNRLLSLLISETSDKEKKFEKLYYSRGCFSGIQAAALLACFKTAPERVRVIRALERRLCRMCCAEAREILNIIQLTNNDRLTALNCVKRTLVDHETTEGIEYILSAFPFETDKKKALEILATVSMHATQQLASGGHQHYAPFGGLYTQSFPGKEGLYGPLEDQVAAKEHKVKPSLPVTACTKPPPSAFVAAPSYIYN 207
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Match: A0A2H1CWM4 (DUF4476 domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_00471 PE=4 SV=1) HSP 1 Score: 227.639 bits (579), Expect = 1.926e-69 Identity = 113/207 (54.59%), Postives = 155/207 (74.88%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYD 759 MAK P + F L++ L ETDS+++KF YY KG FSG QAA L+ +FKTAPE+++VIK+L++RLCRM CAE +EIL +Q N+DR+ AL+ IKRTL+DH+ TEG+E+ILSAFPF++DK +A+ IL+TVS YV +L SGGHQ AP+GGLY+Q+FPLRE LFG + +QL P++P+ AR K+PS++ + PSY Y+ Sbjct: 1 MAKHPLSDGDFSRLLKLLAAETDSMERKFEKFYYSKGCFSGAQAAALMAAFKTAPERVRVIKALERRLCRMCCAEAREILNVVQLTNHDRVFALDCIKRTLVDHETTEGIEYILSAFPFETDKKRAMQILSTVSMYVNKELASGGHQINAPLGGLYTQSFPLREALFGPINEQLAMKNHEVKPSLPVTARVKKIPSMFAAAPSYIYN 207
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Match: A0A4S2MIM0 (DUF4476 domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000628 PE=4 SV=1) HSP 1 Score: 226.098 bits (575), Expect = 9.250e-69 Identity = 112/207 (54.11%), Postives = 144/207 (69.57%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYD 759 MAK P + F L+ L ET +KKF +YY +G FSG Q A LL FKTAPE+++VI++L++RLCRM CAE +EIL +Q NNDRL ALN +KRTL+DH+ TEG+E+ILSAFPF++DK KAL IL TVS + QL SGGHQ YAP GGLY+Q+FP RE L+G LEDQ+ P++P+ A PS + + PSY Y+ Sbjct: 1 MAKVPLSDGDFNRLLSLLISETSDKEKKFEKLYYSRGCFSGIQVAALLACFKTAPERVRVIRALERRLCRMCCAEAREILNIIQLTNNDRLTALNCVKRTLVDHETTEGIEYILSAFPFETDKKKALEILATVSMHATQQLASGGHQNYAPFGGLYTQSFPGREALYGPLEDQVAVKEHKVKPSLPVTACTKPPPSAFVAAPSYIYN 207
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Match: A0A183VRR7 (DUF4476 domain-containing protein OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS3173 PE=4 SV=1) HSP 1 Score: 224.557 bits (571), Expect = 1.511e-68 Identity = 110/206 (53.40%), Postives = 147/206 (71.36%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKY 756 MAK P +S F L R L ET S+ KF+ +YY KG+F+G QAA +L +KTAPE+++VIK+L KRLCRMTCAE EIL MQ N+DR+ AL+ +K TLIDH+ TEG+E+IL AF ++SDK+KAL IL+TVS +V+ +L SGGHQ YAP GGLY+Q+FP RE L+G + +QL P++P+ AR S++ + PSY Y Sbjct: 39 MAKTPLSDSEFERLRRALISETTSVADKFDKLYYSKGYFTGVQAAAILACYKTAPERVQVIKALKKRLCRMTCAEAAEILKVMQLTNHDRIFALDCVKHTLIDHETTEGIEYILKAFIYESDKMKALHILSTVSMHVSRELASGGHQVYAPFGGLYTQSFPGRETLYGPISEQLAVKNHEVKPSLPVTARMNLPESIFRAAPSYAY 244
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Match: A0A074ZLG6 (DUF4476 domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_06132 PE=4 SV=1) HSP 1 Score: 224.942 bits (572), Expect = 2.099e-68 Identity = 113/207 (54.59%), Postives = 145/207 (70.05%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYD 759 MAK P + F L+ L ET +KKF +YY +G FSG QAA LL FKTAPE+++VI++L++RLCRM CAE +EIL +Q NNDRL ALN +KRTL+DH+ TEG+E+ILSAFPF++DK KAL IL TVS + QL SGGHQ YAP GGLY+Q+FP RE+L+G LEDQ P++P+ A PS + + PSY Y+ Sbjct: 1 MAKVPLSDGDFNRLLSLLVSETSDKEKKFEKLYYSRGCFSGIQAAALLACFKTAPERVRVIRALERRLCRMCCAEAREILNVIQLTNNDRLTALNCVKRTLVDHETTEGIEYILSAFPFETDKKKALEILATVSMHATQQLASGGHQHYAPFGGLYTQSFPGRESLYGPLEDQ-----HKVKPSLPVTACTKPPPSAFVAAPSYIYN 202
BLAST of DUF4476 domain-containing protein vs. Planmine SMEST
Match: SMESG000045760.1 (SMESG000045760.1) HSP 1 Score: 500.745 bits (1288), Expect = 0.000e+0 Identity = 258/258 (100.00%), Postives = 258/258 (100.00%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYDTTYTYLQDRGYPGARGFPEHDXXXXXXXXXXXXLGFHQGPPAPTGYQTLKE 912 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYDTTYTYLQDRGYPGARGFPEHDPRPPTYPSGSPPLGFHQGPPAPTGYQTLKE Sbjct: 1 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYDTTYTYLQDRGYPGARGFPEHDPRPPTYPSGSPPLGFHQGPPAPTGYQTLKE 258
BLAST of DUF4476 domain-containing protein vs. Planmine SMEST
Match: SMESG000055714.1 (SMESG000055714.1) HSP 1 Score: 275.404 bits (703), Expect = 1.528e-92 Identity = 133/217 (61.29%), Postives = 166/217 (76.50%), Query Frame = 1 Query: 139 MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSFKTAPEKLKVIKSLDKRLCRMTCAEGKEILIAMQPINNDRLEALNIIKRTLIDHQCTEGMEHILSAFPFQSDKLKALGILTTVSSYVADQLPSGGHQQYAPVGGLYSQNFPLRENLFGSLEDQLLRMPGSGLPAIPLRARPGKVPSLYTSHPSYKYDTTYTYLQDRG 789 MAK P D F L+ ++ +ET SI+KKFNIVYY K FF+G+QAA LL +KTAPE+LKVI +L+KRLCRMTC E K IL A Q NND++ AL+ IKRTLIDHQ TEG+E+ILSAFPF +DKLKA+ IL TVSSYV++++ +GGHQ Y+PVGGL+SQ+FPL+ NLFG +++QL G G PAI ARPGKV SLY SHPSY+YD ++ G Sbjct: 1 MAKTPVDSETFNILINDIVKETTSIEKKFNIVYYTKFFFAGSQAAHLLIQYKTAPERLKVISALEKRLCRMTCTEAKLILDAFQLTNNDKVFALDCIKRTLIDHQSTEGIEYILSAFPFTNDKLKAMSILATVSSYVSEKMSAGGHQLYSPVGGLFSQSFPLKANLFGPIDEQLENQQGKGQPAIAPHARPGKVDSLYRSHPSYRYDNGVSWKSSMG 217 The following BLAST results are available for this feature:
BLAST of DUF4476 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DUF4476 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of DUF4476 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30005870 ID=SMED30005870|Name=DUF4476 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1006bpback to top protein sequence of SMED30005870-orf-1 >SMED30005870-orf-1 ID=SMED30005870-orf-1|Name=SMED30005870-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=266bp MAKKPADESYFMDLVRNLKEETDSIDKKFNIVYYGKGFFSGTQAAILLKSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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