Carbonyl reductase 1

Overview
NameCarbonyl reductase 1
Smed IDSMED30005862
Length (bp)937
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Carbonyl reductase 1 (SMED30005862) t-SNE clustered cells

Violin plots show distribution of expression levels for Carbonyl reductase 1 (SMED30005862) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Carbonyl reductase 1 (SMED30005862) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Carbonyl reductase 1 (SMED30005862) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30005862

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30005862h1SMcG0003519 dd_Smed_v4_2165_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30005862h1SMcG0003519 dd_Smed_v4_2165_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30005862h1SMcG0003519 dd_Smed_v4_2165_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30005862h1SMcG0003519 dd_Smed_v4_2165_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30005862h1SMcG0003519 dd_Smed_v4_2165_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30005862h1SMcG0003519 Contig48735uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30005862h1SMcG0003519 Contig48735newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Match: CBR1 (carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548])

HSP 1 Score: 248.825 bits (634), Expect = 3.277e-81
Identity = 129/282 (45.74%), Postives = 181/282 (64.18%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++ + V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K   R+VNVSS+MSV  LK  S EL ++F  E +T  EL   M+ FV+  K+   + +GWP  AYG++K+ VT ++ I    L+E+ + D  KIL+N CCPG+V TDM+  K   +  EGA+TP YLA LP   E P+G+F+S + V +W
Sbjct:    1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGD--KILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Match: CBR3 (carbonyl reductase 3 [Source:HGNC Symbol;Acc:HGNC:1549])

HSP 1 Score: 231.106 bits (588), Expect = 2.537e-74
Identity = 116/280 (41.43%), Postives = 172/280 (61.43%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRF-LEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAE--EYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++  +V LVTG+N+GIG  I   L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGL+VL+NNA +AFK+D   PF  +AE+TL TNF  T  MC E +PI+K + R+VN+SS+  +   +  S +L +RF  E +T  +L + M  FV+  K +  E +GWP   YG+SKL VT ++ ILA   + +  + +IL+N CCPG V TDM       T+ EGA+TP YLA LP     P G+ + ++ V  W
Sbjct:    1 MSSCSRVALVTGANRGIGLAIARELCRQFSGD---VVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Match: CBR1 (carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548])

HSP 1 Score: 127.102 bits (318), Expect = 3.469e-35
Identity = 65/139 (46.76%), Postives = 89/139 (64.03%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLV 438
            M++ + V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K  A  V
Sbjct:    1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQASCV 136
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Match: CBR1 (carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548])

HSP 1 Score: 125.561 bits (314), Expect = 1.527e-34
Identity = 63/133 (47.37%), Postives = 87/133 (65.41%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILK 420
            M++ + V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K
Sbjct:    1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIK 130
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Match: CBR1 (carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548])

HSP 1 Score: 125.561 bits (314), Expect = 3.830e-34
Identity = 63/133 (47.37%), Postives = 87/133 (65.41%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILK 420
            M++ + V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K
Sbjct:    1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIK 130
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Match: F20G2.1 (pep chromosome:WBcel235:V:13752267:13753580:-1 gene:WBGene00008985.1 transcript:F20G2.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F20G2.1)

HSP 1 Score: 70.4774 bits (171), Expect = 6.523e-14
Identity = 79/252 (31.35%), Postives = 106/252 (42.06%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEG-KGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAFKNDSTAPFSEQAEV-TLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVT---KMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADT 771
            K +L+TG+N+GIG G+++   K  N D  II  T R+P       +EL   K   V   QLDI C+ S + L   + +  G  GL VLINNAGI    D     S    +  L TN   T+ +  E +P+LK  A               K  GE Y      +  S + N         K D       P  AY +SK A+    K   +   +Y      IL+   CPG+V TDM    G L I +   T
Sbjct:    4 KSILITGANRGIGLGLLKQFIK--NKDVQIIIGTCRDPS----NATELNSIKDTRVHILQLDIDCDDSIRKLGAEVEKLVGEDGLTVLINNAGIFVPYDIDGEKSRSTLIRQLETNTISTVLITQELLPLLKRAA--------------AKNRGEGYS-----INRSAIINISSTAGSITKIDA--SYNIPLVAYRMSKSALNSFGKSCSVDLAKYH-----ILVTTFCPGWVKTDMGGANGKLEIDDATKT 223
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Match: C55A6.4 (pep chromosome:WBcel235:V:11516445:11517889:-1 gene:WBGene00008333.1 transcript:C55A6.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C55A6.4)

HSP 1 Score: 70.0922 bits (170), Expect = 9.281e-14
Identity = 77/254 (30.31%), Postives = 114/254 (44.88%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELG--MKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAF-----KNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSG-ELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQ-AYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYE 759
            S K V++TG+N+GIG G+V+   K  N     I  TAR+ E    +K IS+       V   QL++ C+KS       + +  G  GL++L+NNAG A         + A F+EQ    L  N T  + +  + +P+      L+  SS        K+SG +L       +T+S     M DF              P   AY ISK A+      LA + ++D   IL+    PG+V TDM   K  LT+ +
Sbjct:    2 SPKSVVITGANRGIGLGLVQEFVKDKNIRH--IIATARDVEKATDLKAISD-----PRVTALQLEVTCDKSMDTFVSKVEEIVGSDGLNLLVNNAGNAVDYPCKAKPNRALFAEQ----LNVNTTSVVILTQKLMPL------LIKASS--------KVSGDQLSASRAAVVTISSGLASMTDFATGGHA--------PNAFAYRISKAAINMFGRALANDMKDD--HILVASIGPGWVKTDMGGEKALLTVEQ 220
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Match: C55A6.7 (pep chromosome:WBcel235:V:11519335:11520530:-1 gene:WBGene00008336.1 transcript:C55A6.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C55A6.7)

HSP 1 Score: 68.1662 bits (165), Expect = 4.416e-13
Identity = 63/248 (25.40%), Postives = 110/248 (44.35%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAFKNDSTAPFSEQAEVTL-GTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGA 765
            S K V+VTGSN+G+G G+V+   K  N    I      +    +K I +     +H+   QL +G ++S  +  + + +  G  GL +LINNA +     +      +  + L  +N    + +    +P++              +   K+  G+        ++   + N   +F+ +  E+T     +   AY ++K AV + T  L+ + ++D   IL    CPG V TDMS  KG LTI E +
Sbjct:    2 SPKSVVVTGSNRGLGFGLVQQFLKDPNVQHVIATARDVDKATALKGICDPR---LHI--LQLSLGSDESIANFAEKVSEIVGESGLTLLINNAAVMLPYVTKQKPDRKVVLDLFESNTIGPMMLTQSLVPLI--------------IKASKRQEGDTLS-----VSRGAIINIASEFLGSISENTSGSGEYKAMAYRMTKCAVNQFTKTLSIDLKDD--HILTAGICPGMVQTDMSKGKGQLTIEESS 223
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Match: C55A6.6 (pep chromosome:WBcel235:V:11513665:11514737:-1 gene:WBGene00008335.1 transcript:C55A6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C55A6.6)

HSP 1 Score: 67.0106 bits (162), Expect = 1.068e-12
Identity = 72/251 (28.69%), Postives = 115/251 (45.82%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYL--TARNPELG--MKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAFKN-DSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSG-ELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYE 759
            S K V++TG+N+GIG G+V+   K    D+ I+++  T R+ E    +K I++      HV    L + C+KS       + +  G  GL++L+NNAGIA K    T P        L  N T  + +  + +P+L   A               K+SG +L       +T+S         + +  E+T     +   AY +SK AV      LA + ++D   IL+   CPG+V TDM   +  LT+ +
Sbjct:    2 SPKSVVITGANRGIGLGLVQEFVK----DKNILHIIATVRDVEKATDLKAINDP-----HVHVLPLIVTCDKSIDSFVTKVEEIVGSDGLNLLVNNAGIAVKYLTKTKPNRSMIAEQLDVNTTSVVILTQKLLPLLTRAA--------------SKVSGDQLSVSRAAVITISS-------GLGSITENTTGSAVFDSLAYRMSKAAVNMFGRTLAIDLQDD--HILVVNFCPGWVQTDMGGQEAMLTVEQ 220
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Match: F20G2.2 (pep chromosome:WBcel235:V:13755011:13756409:-1 gene:WBGene00008986.1 transcript:F20G2.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F20G2.2)

HSP 1 Score: 61.2326 bits (147), Expect = 1.004e-10
Identity = 70/264 (26.52%), Postives = 115/264 (43.56%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAFKNDSTAPFSEQAEV-TLGTNFTDTLKMCLEFIPILK------------LN-ARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSEL-QNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADT 771
            S K +L+TG+N+GIG G+++   K  + D  II  T R+P    + +S L+   +H+    LDI C++S   L   + +  G  GL VL+NNAGI    D     + +  +  L TN   T  +  EF+P+LK            +N A +VN+SS  +  +++K+ G     F  P+    + ++ ++ F K+   D  ++                                IL+   CPG+V T M      L I +   T
Sbjct:    2 SPKSLLITGANRGIGLGLLKQFLK--HKDIQIIIATCRDPS-KAEELSNLKDSRLHI--LPLDIDCDESISKLYAEVEKLVGEDGLTVLLNNAGILLPYDVEGEKNRKTLIRQLETNSVSTALITQEFLPLLKKAAAKNGGDGYSINRAAIVNISS--TAASVEKIDGT----FNGPLVAYRMSKSALNSFAKSCSIDLAKY-------------------------------HILVTSFCPGWVKTGMGGANAMLEIEDATKT 223
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Match: CG11200 (gene:FBgn0034500 transcript:FBtr0086299)

HSP 1 Score: 65.4698 bits (158), Expect = 1.061e-11
Identity = 78/289 (26.99%), Postives = 118/289 (40.83%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNP---ELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQA---EVTLGTNFTDTLKMCLEFIPILKL------NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTI-----------YEGADTPCYLATLPIGTETPYGEFLSN 834
            ++ ++TG N+GIG  IVE L     A +  + +  R+P   E  + +I +L      +   QLD+G  KS K     + + Y  +D+L+NNAGI F     APF   A   E     NF     +    +P L+       N+R+VNVSS ++++      G +              NY        K+       +P  AY  SKLA    T  L      +   + +N   PG VDTD+  H    ++             G+ T  + A  P   E   G +LSN
Sbjct:   68 RIAVITGGNRGIGLRIVEKLL----ACDMTVVMGVRDPKIAETAVASIVDLNATKGKLICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIMF-----APFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGKEGRNSRIVNVSSCVNLI------GRI--------------NY--------KDINGTKHYYPGTAYSQSKLAQILFTRHLQTLLDAEKSHVQVNVVHPGIVDTDLFEHSATTSVPIFKKLFFKTPERGSRTVVFAAIDP-SIEGQGGTYLSN 318
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Match: CG11200 (gene:FBgn0034500 transcript:FBtr0086300)

HSP 1 Score: 65.4698 bits (158), Expect = 1.061e-11
Identity = 78/289 (26.99%), Postives = 118/289 (40.83%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNP---ELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQA---EVTLGTNFTDTLKMCLEFIPILKL------NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTI-----------YEGADTPCYLATLPIGTETPYGEFLSN 834
            ++ ++TG N+GIG  IVE L     A +  + +  R+P   E  + +I +L      +   QLD+G  KS K     + + Y  +D+L+NNAGI F     APF   A   E     NF     +    +P L+       N+R+VNVSS ++++      G +              NY        K+       +P  AY  SKLA    T  L      +   + +N   PG VDTD+  H    ++             G+ T  + A  P   E   G +LSN
Sbjct:   68 RIAVITGGNRGIGLRIVEKLL----ACDMTVVMGVRDPKIAETAVASIVDLNATKGKLICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIMF-----APFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGKEGRNSRIVNVSSCVNLI------GRI--------------NY--------KDINGTKHYYPGTAYSQSKLAQILFTRHLQTLLDAEKSHVQVNVVHPGIVDTDLFEHSATTSVPIFKKLFFKTPERGSRTVVFAAIDP-SIEGQGGTYLSN 318
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Match: CG11200 (gene:FBgn0034500 transcript:FBtr0344185)

HSP 1 Score: 65.4698 bits (158), Expect = 1.061e-11
Identity = 78/289 (26.99%), Postives = 118/289 (40.83%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNP---ELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQA---EVTLGTNFTDTLKMCLEFIPILKL------NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTI-----------YEGADTPCYLATLPIGTETPYGEFLSN 834
            ++ ++TG N+GIG  IVE L     A +  + +  R+P   E  + +I +L      +   QLD+G  KS K     + + Y  +D+L+NNAGI F     APF   A   E     NF     +    +P L+       N+R+VNVSS ++++      G +              NY        K+       +P  AY  SKLA    T  L      +   + +N   PG VDTD+  H    ++             G+ T  + A  P   E   G +LSN
Sbjct:   68 RIAVITGGNRGIGLRIVEKLL----ACDMTVVMGVRDPKIAETAVASIVDLNATKGKLICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIMF-----APFKLTADGYESHFAINFLGHFLLTHLLLPQLRAAGKEGRNSRIVNVSSCVNLI------GRI--------------NY--------KDINGTKHYYPGTAYSQSKLAQILFTRHLQTLLDAEKSHVQVNVVHPGIVDTDLFEHSATTSVPIFKKLFFKTPERGSRTVVFAAIDP-SIEGQGGTYLSN 318
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Match: CG3699 (gene:FBgn0040349 transcript:FBtr0070186)

HSP 1 Score: 62.3882 bits (150), Expect = 4.943e-11
Identity = 65/245 (26.53%), Postives = 104/245 (42.45%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQE----YGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIP-ILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKG 741
            M+ S KVV+VTG++ GIG  I + L +    +   + L  RN       ++ LE     +K  Q +I      KD  D +VQ+    +G +DVL+NNAGI  K        E+ +  L TN    + +    +P +LK    +VNVSS   +   +  +G L                                     +YG+SK A+ + T I+A E     + + +N   PG+V T++  + G
Sbjct:    1 MSLSNKVVIVTGASSGIGAAIAQVLAR----EGATLALVGRN-------VANLEATKKSLKGTQAEIVVADVTKD-ADAIVQQTLAKFGRIDVLVNNAGILGKGGLIDLDIEEFDAVLNTNLRGVILLTKAVLPHLLKTKGAVVNVSSCAGI---RPFAGAL-------------------------------------SYGVSKAALDQFTKIVALEMA--PQGVRVNSVNPGFVVTNIHRNIG 191
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Match: CG7322 (gene:FBgn0030968 transcript:FBtr0346018)

HSP 1 Score: 56.6102 bits (135), Expect = 4.056e-9
Identity = 49/146 (33.56%), Postives = 74/146 (50.68%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDI-GCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCL----EFIPILKLNARLVNVSSMMS 459
            KV+LVTG+  GIG+ +V+ L    +A   +I + AR PE   + ++      +H++  QLD+ G +  R+ L    +     LD L+NNAG+A       PF E  E    T+F   +K         +P LK  A +VNVSS+ S
Sbjct:    8 KVILVTGAGAGIGQALVKQL---ASAGATVIAV-ARKPEQLQQLVAF---DPVHIQPLQLDLSGWQAVREGLAKVPL-----LDGLVNNAGVAI----IKPFEELTEQDFDTHFDVNIKAVFNVTQSLLPRLKDGASIVNVSSIAS 137
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Match: cbr1 (carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030902-2])

HSP 1 Score: 238.039 bits (606), Expect = 3.222e-77
Identity = 131/277 (47.29%), Postives = 164/277 (59.21%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            KV LVTG+NKGIG  IV  L K    D   +YL++R+   G   +  L+ +G+H  FHQLDI    S +  +D+  ++YGGLDVLINNAGIAFK   T PF  QA+VTL TNF  T  MC  F+PI+K   RLVNVSS M  M L + S EL  RF  + +T  EL   M  FV+ A+E     +GWP  AYGISK  +T +T I    L +E   D   IL N CCPG+V TDM+      +  EGA TP YLA LP G + P+G+F+S   V  W
Sbjct:    5 KVALVTGANKGIGFAIVRALCKEYTGD---VYLSSRDVGRGTAAVDSLKKEGLHPLFHQLDINDPNSVRTARDFFQEKYGGLDVLINNAGIAFKMADTTPFGTQADVTLKTNFFATRDMCNVFLPIIKPGGRLVNVSSGMGSMALGRCSPELQARFRSDDITEEELNGLMERFVREAQEGVHSERGWPSTAYGISKTGLTTLTRIQARNLTKERPGDG--ILCNACCPGWVRTDMAGPNATKSPDEGAITPVYLALLPAGAKEPHGQFVSEMKVQPW 276
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Match: cbr1 (carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030902-2])

HSP 1 Score: 238.039 bits (606), Expect = 3.222e-77
Identity = 131/277 (47.29%), Postives = 164/277 (59.21%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            KV LVTG+NKGIG  IV  L K    D   +YL++R+   G   +  L+ +G+H  FHQLDI    S +  +D+  ++YGGLDVLINNAGIAFK   T PF  QA+VTL TNF  T  MC  F+PI+K   RLVNVSS M  M L + S EL  RF  + +T  EL   M  FV+ A+E     +GWP  AYGISK  +T +T I    L +E   D   IL N CCPG+V TDM+      +  EGA TP YLA LP G + P+G+F+S   V  W
Sbjct:    5 KVALVTGANKGIGFAIVRALCKEYTGD---VYLSSRDVGRGTAAVDSLKKEGLHPLFHQLDINDPNSVRTARDFFQEKYGGLDVLINNAGIAFKMADTTPFGTQADVTLKTNFFATRDMCNVFLPIIKPGGRLVNVSSGMGSMALGRCSPELQARFRSDDITEEELNGLMERFVREAQEGVHSERGWPSTAYGISKTGLTTLTRIQARNLTKERPGDG--ILCNACCPGWVRTDMAGPNATKSPDEGAITPVYLALLPAGAKEPHGQFVSEMKVQPW 276
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Match: cbr1l (carbonyl reductase 1-like [Source:ZFIN;Acc:ZDB-GENE-030131-9642])

HSP 1 Score: 236.498 bits (602), Expect = 1.158e-76
Identity = 133/279 (47.67%), Postives = 180/279 (64.52%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGI-HVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            S KV +VTG+NKGIG  IV+ L K     +  I LTARN +LG + I+ L+ +G  +V FHQLDI  + S   LK +L ++YGGLDVLINNAGIAFKN +T PF EQAEVT+ TNF  TL  C   +PIL+ NAR+VNVSS +S  +L + S EL  +F  + ++  EL   M +FV+ A+      KGWP  AYG +K+ VT ++ I A    N++R    IL+N CCPG+V TDM+  K   +  EGA+TP YLA LP G + P+G+ + ++ V +W
Sbjct:    2 SQKVAVVTGANKGIGLAIVKGLCKAGFTGD--ILLTARNEKLGQEAIAGLQSEGFKNVVFHQLDICDQGSCMKLKKFLEEKYGGLDVLINNAGIAFKNAATEPFGEQAEVTMRTNFWGTLWACHALLPILRANARVVNVSSFVSKKSLDQCSAELQAKFRNKDLSEEELCLLMGEFVQDAQAGDHSAKGWPNTAYGTTKIGVTVLSRIQA-RVLNETRPGDGILLNACCPGWVRTDMAGPKAPKSPEEGAETPVYLAMLPEGAKEPHGQLVWDKTVQEW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Match: si:dkey-12e7.4 (si:dkey-12e7.4 [Source:ZFIN;Acc:ZDB-GENE-050419-83])

HSP 1 Score: 56.225 bits (134), Expect = 8.299e-9
Identity = 76/277 (27.44%), Postives = 121/277 (43.68%), Query Frame = 1 
Query:   43 VLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDI----GCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKL-----------NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFL 828
            +++TG+++G+G  IVE+L  T       I  TARNP  G K +  L  +  ++   +LD+      E++  ++++ LVQE G L+ LINNAGI    +     ++Q      TN    L +    +P+LK             A ++NV+S++  + L                      Y  D     + DT   K +P   Y  SK A+  +T  LA +   D   IL     PG+V TDM   +  L+  E   +   L+ +   TE  +G FL
Sbjct:   11 LMITGASRGLGLQIVESLV-TGGFSPGKIIATARNPN-GAKELQRLAEEYQNIHIIKLDVISQESIERAAAEVEE-LVQEEG-LNCLINNAGINVVANLETVTADQMLENFHTNSVAPLMITKAMLPLLKRAAAKGTGMGIHRAAVINVTSLLGSVEL----------------------YWGD-----RADTF--KWYP---YRTSKSALNMVTRCLAVDLEADG--ILCMALHPGWVRTDMGGPEAPLSPEESISS--VLSVIGGLTEKDHGSFL 247
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Match: dhrs12 (dehydrogenase/reductase (SDR family) member 12 [Source:ZFIN;Acc:ZDB-GENE-060929-1134])

HSP 1 Score: 55.8398 bits (133), Expect = 1.634e-8
Identity = 76/293 (25.94%), Postives = 115/293 (39.25%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARN---PELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKL--NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDM---------SSHKGHL-TIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE*ELEF 870
            +  ++TG+N GIGK     + K        ++L  RN    E   K I E + K  +V  H +D+   +   +      Q +  L VLINNAG            +  E    TN   T  +    IP LK   N R++ VSS    M ++KL+ E            +LQ     F K++ + T+        AY  +K    +   I+ E++    ++I  +   PG+ DT              K  L T  +GADT  +LA     +  P G F  +R  V     L F
Sbjct:   41 RSFIITGANSGIGKAAAYEIAKRGG----TVHLVCRNKDRAEEARKDIVE-QSKSENVHVHLVDMSSPRKVWEFASGFSQNH-NLHVLINNAGCMVNQRELT--EDGLEKNFATNTLGTYILTTALIPTLKRSENPRVITVSS--GGMLVQKLNVE------------DLQ-----FEKSSFDGTM--------AYAQNK----RQQVIMTEQWATQHKEIHFSSMHPGWADTPAVRSSMPDFYEKMKNKLRTEAQGADTVVWLAVSDAASRQPSGLFFQDRKAVSTHLPLAF 294
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Match: cbr1 (carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc:496612])

HSP 1 Score: 252.292 bits (643), Expect = 1.520e-82
Identity = 137/281 (48.75%), Postives = 181/281 (64.41%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE 855
            AS KV +VTG NKGIG  IV+ L K    D   +YLTAR+P+LG + +  L E +G+   FHQLDI   +S + L  +L ++YGG+DVLINNAG+AFK D T P   QAEVTL TNF  T  +C E +P++K + R+VNVSS+ S M L + S EL K F  + +T  EL   M  FV+ AK+  L+ +GWP   YG+SK+ VT ++ I A E  N+ RK   IL+N CCPG+V TDM+  K   T  EGA+TP YLA LP    +P+GE +S++ VV WE
Sbjct:    2 ASAKVAVVTGGNKGIGLAIVKALCKQFKGD---VYLTARDPKLGEEAVRALKEQEGLSPHFHQLDINDLQSIRTLGSFLKEKYGGIDVLINNAGVAFKVDDTTPIGTQAEVTLKTNFFATRDVCNELLPLIKPHGRVVNVSSIASYMALGRCSPELQKVFRSDTITEEELVTLMEKFVEDAKKGALQEQGWPDTPYGVSKIGVTVLSRIQAREL-NEKRKDDGILLNACCPGWVRTDMAGSKAPKTPDEGAETPVYLALLPNNAHSPHGELVSDKKVVPWE 278
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Match: cbr1 (carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc:496612])

HSP 1 Score: 245.743 bits (626), Expect = 3.944e-80
Identity = 136/280 (48.57%), Postives = 175/280 (62.50%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            AS KV +VTG NKGIG  IV  L K    D   +YLTAR+P+LG + +  L E +G+   FHQLDI   +S + L  +L ++YGG+DVLINNAGIAFK   T PF  QAEVTL TNF  T   C E +P++K   R+VNVSSM S M L + S EL K F  + +T  EL   M  FV+ AK+   + +GWP  AYG+SK+ VT ++ I A E  N+ RK   IL+N CCPG+V TDM+      +  EGA+TP YLA LP    +P+GE +S + VV W
Sbjct:    2 ASAKVAVVTGGNKGIGLAIVRALCKQFKGD---VYLTARDPKLGEEAVRALKEQEGLSPHFHQLDINDLQSIRALGGFLKEKYGGIDVLINNAGIAFKVADTTPFGTQAEVTLKTNFFATRDACHELLPLIKPRGRVVNVSSMASYMALGRCSQELQKVFRSDTITEEELVTLMEKFVEDAKKGAHQKEGWPNTAYGVSKIGVTVLSRIQAREL-NEKRKDDGILLNACCPGWVRTDMAGPNATKSPDEGAETPVYLALLPNNAHSPHGELVSEKKVVPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Match: cbr1 (carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc:496612])

HSP 1 Score: 245.743 bits (626), Expect = 3.944e-80
Identity = 136/280 (48.57%), Postives = 175/280 (62.50%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            AS KV +VTG NKGIG  IV  L K    D   +YLTAR+P+LG + +  L E +G+   FHQLDI   +S + L  +L ++YGG+DVLINNAGIAFK   T PF  QAEVTL TNF  T   C E +P++K   R+VNVSSM S M L + S EL K F  + +T  EL   M  FV+ AK+   + +GWP  AYG+SK+ VT ++ I A E  N+ RK   IL+N CCPG+V TDM+      +  EGA+TP YLA LP    +P+GE +S + VV W
Sbjct:    2 ASAKVAVVTGGNKGIGLAIVRALCKQFKGD---VYLTARDPKLGEEAVRALKEQEGLSPHFHQLDINDLQSIRALGGFLKEKYGGIDVLINNAGIAFKVADTTPFGTQAEVTLKTNFFATRDACHELLPLIKPRGRVVNVSSMASYMALGRCSQELQKVFRSDTITEEELVTLMEKFVEDAKKGAHQKEGWPNTAYGVSKIGVTVLSRIQAREL-NEKRKDDGILLNACCPGWVRTDMAGPNATKSPDEGAETPVYLALLPNNAHSPHGELVSEKKVVPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Match: cbr1 (carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc:496612])

HSP 1 Score: 241.121 bits (614), Expect = 2.786e-78
Identity = 133/280 (47.50%), Postives = 174/280 (62.14%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            AS KV +VTG NKGIG  IV  L K    D   +YLTAR+P+LG + +  L E +G+   FHQLDI   +S + L  +L ++YGG+DVLINNAGIAFK     PF  QA VTL TNF  T  +C E +P ++   R+VNVSSM+S   L+  S EL K F  + +T  EL   M  FV+ AK+   + +GWP  AYG+SK+ VT ++ I A E  N+ RK   IL+N CCPG+V TDM+  K   +  EGA+TP YLA LP    +P+GE +S + VV W
Sbjct:    2 ASAKVAVVTGGNKGIGLAIVRALCKQFKGD---VYLTARDPKLGEEAVRALKEQEGLSPHFHQLDINDLQSIRALGSFLKEKYGGIDVLINNAGIAFKGTDPTPFGTQANVTLQTNFFATRDVCNELLPQVRPQGRVVNVSSMLSSSALQGCSPELQKVFRSDTITEEELVTLMEKFVEDAKKGAHQKEGWPNTAYGVSKVGVTVLSRIQAREL-NEKRKDDGILLNACCPGWVRTDMAGPKAPKSPDEGAETPVYLALLPNNAHSPHGELVSEKKVVPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Match: cbr1 (carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc:496612])

HSP 1 Score: 240.736 bits (613), Expect = 4.444e-78
Identity = 133/280 (47.50%), Postives = 174/280 (62.14%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            AS KV +VTG NKGIG  IV  L K    D   +YLTAR+P+LG + +  L E +G+   FHQLDI   +S + L  +L ++YGG+DVLINNAGIAFK     PF  QA VTL TNF  T  +C E +P ++   R+VNVSSM+S   L+  S EL K F  + +T  EL   M  FV+ AK+   + +GWP  AYG+SK+ VT ++ I A E  N+ RK   IL+N CCPG+V TDM+  K   +  EGA+TP YLA LP    +P+GE +S + VV W
Sbjct:    2 ASAKVAVVTGGNKGIGLAIVRALCKQFKGD---VYLTARDPKLGEEAVRALKEQEGLSPHFHQLDINDLQSIRALGGFLKEKYGGIDVLINNAGIAFKGTDPTPFGTQANVTLQTNFFATRDVCNELLPQVRPQGRVVNVSSMLSSSALQGCSPELQKVFRSDTITEEELVTLMEKFVEDAKKGAHQKEGWPNTAYGVSKVGVTVLSRIQAREL-NEKRKDDGILLNACCPGWVRTDMAGPKAPKSPDEGAETPVYLALLPNNAHSPHGELVSEKKVVPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Match: Cbr1 (carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88284])

HSP 1 Score: 248.054 bits (632), Expect = 4.559e-81
Identity = 126/280 (45.00%), Postives = 178/280 (63.57%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSR--KILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++S  V LVTG+NKGIG  I   L +  + D   + L AR+ E G   + +L+ +G+  +FHQLDI   +S + L+D+L++EYGGLDVL+NNAGIAFK +   PF  QAEVT+ TNF  T  +C E +P++K   R+VNVSSM+S+  LK    EL ++F  E +T  EL   M+ FV+  K+     +GWP  AYG++K+ VT ++ ILA +     R  KIL+N CCPG+V TDM+  K   +  EGA+TP YLA LP   E P+G+F+ ++ V  W
Sbjct:    1 MSSSRPVALVTGANKGIGFAITRDLCRKFSGD---VVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRSETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Match: Cbr3 (carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:1309992])

HSP 1 Score: 243.432 bits (620), Expect = 2.769e-79
Identity = 120/280 (42.86%), Postives = 178/280 (63.57%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRF-LEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEY--RNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++  +V LVTG+NKGIG  I   L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGL+VL+NNAGIAF+ D   PF  QAEVTL TNF  T  +C E +PI+K + R+VN+SS+  +  L+    +L ++F  + +T  +L + M  FV+  K +  E +GWP  AYG+SKL VT +T ILA +   +  + +IL+N CCPG+V TDM+  +G  T+ EGA+TP YLA LP     P+G+ + ++ V  W
Sbjct:    1 MSSCSRVALVTGANKGIGFAITRDLCRKFSGD---VVLTARDEARGRAAVQQLQAEGLSPRFHQLDIDDPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTPFDIQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNISSLQGLKALENCREDLQEKFRCDTLTEVDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKADRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQTW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Match: Gm5678 (predicted gene 5678 [Source:MGI Symbol;Acc:MGI:3646098])

HSP 1 Score: 234.187 bits (596), Expect = 9.617e-76
Identity = 122/280 (43.57%), Postives = 175/280 (62.50%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSR--KILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M+   +V LVTG NKGIG  I+  L +  + D   + LTAR+   G   + +L+ +G++ +FHQLDI   +S   L+D+L++EY GLDVL+NNAGIAFK D   PF  + EVT+ TNF  T  +C E +P++K   R+VNVSSM+S+  LK  S EL ++F  E +T  EL   M+ +V+ AK+     + WP  AY +SK+ VT ++ ILA +     R  KIL+N CCPG+V TDM+  +   +  EGA+TP YLA LP   E P+G+F+ ++ V  W
Sbjct:    1 MSPCSRVALVTGGNKGIGFEIIRDLCQKFSGD---VVLTARDEARGCAAVQKLQAEGLNPRFHQLDIDDPQSIHALRDFLLKEYKGLDVLVNNAGIAFKVDDPTPFHIKGEVTMKTNFFGTRDVCKEMLPLIKPQGRVVNVSSMVSLSALKDCSPELQQKFRSETITEEELVGLMNKYVEDAKKGVYVKEDWPNSAYEVSKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMTGPQATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKTVEPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Match: Cbr1 (carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88284])

HSP 1 Score: 128.642 bits (322), Expect = 1.984e-36
Identity = 63/133 (47.37%), Postives = 89/133 (66.92%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILK 420
            M++S  V LVTG+NKGIG  I   L +  + D   + L AR+ E G   + +L+ +G+  +FHQLDI   +S + L+D+L++EYGGLDVL+NNAGIAFK +   PF  QAEVT+ TNF  T  +C E +P++K
Sbjct:    1 MSSSRPVALVTGANKGIGFAITRDLCRKFSGD---VVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIK 130
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Match: Cbr3 (carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:1309992])

HSP 1 Score: 93.9745 bits (232), Expect = 2.169e-23
Identity = 45/100 (45.00%), Postives = 67/100 (67.00%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKN 321
            M++  +V LVTG+NKGIG  I   L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGL+VL+NNAGIAF+ 
Sbjct:    1 MSSCSRVALVTGANKGIGFAITRDLCRKFSGD---VVLTARDEARGRAAVQQLQAEGLSPRFHQLDIDDPQSIRALRDFLRKEYGGLNVLVNNAGIAFRR 97
[Close]
BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Match: sp|Q5RCU5|CBR1_PONAB (Carbonyl reductase [NADPH] 1 OS=Pongo abelii OX=9601 GN=CBR1 PE=2 SV=3)

HSP 1 Score: 249.98 bits (637), Expect = 5.425e-81
Identity = 129/282 (45.74%), Postives = 181/282 (64.18%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++ M V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K   R+VNVSS+MSV  LK  S EL ++F  E +T  EL   M+ FV+  K+   + +GWP  AYG++K+ VT ++ I    L+E+ + D  +IL+N CCPG+V TDM+  K   +  EGA+TP YLA LP   E P+G+F+S + V +W
Sbjct:    1 MSSGMHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGD--RILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
[Close]
BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Match: sp|P16152|CBR1_HUMAN (Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3)

HSP 1 Score: 248.825 bits (634), Expect = 1.574e-80
Identity = 129/282 (45.74%), Postives = 181/282 (64.18%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++ + V LVTG NKGIG  IV  L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K   R+VNVSS+MSV  LK  S EL ++F  E +T  EL   M+ FV+  K+   + +GWP  AYG++K+ VT ++ I    L+E+ + D  KIL+N CCPG+V TDM+  K   +  EGA+TP YLA LP   E P+G+F+S + V +W
Sbjct:    1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGD---VVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGD--KILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
[Close]
BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Match: sp|P48758|CBR1_MOUSE (Carbonyl reductase [NADPH] 1 OS=Mus musculus OX=10090 GN=Cbr1 PE=1 SV=3)

HSP 1 Score: 248.054 bits (632), Expect = 3.189e-80
Identity = 126/280 (45.00%), Postives = 178/280 (63.57%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSR--KILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++S  V LVTG+NKGIG  I   L +  + D   + L AR+ E G   + +L+ +G+  +FHQLDI   +S + L+D+L++EYGGLDVL+NNAGIAFK +   PF  QAEVT+ TNF  T  +C E +P++K   R+VNVSSM+S+  LK    EL ++F  E +T  EL   M+ FV+  K+     +GWP  AYG++K+ VT ++ ILA +     R  KIL+N CCPG+V TDM+  K   +  EGA+TP YLA LP   E P+G+F+ ++ V  W
Sbjct:    1 MSSSRPVALVTGANKGIGFAITRDLCRKFSGD---VVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRSETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEPW 277
[Close]
BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Match: sp|Q8MI29|CBR1_MACFA (Carbonyl reductase [NADPH] 1 OS=Macaca fascicularis OX=9541 GN=CBR1 PE=2 SV=1)

HSP 1 Score: 246.514 bits (628), Expect = 1.240e-79
Identity = 125/282 (44.33%), Postives = 181/282 (64.18%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYI----LAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M + ++V LVTGSNKGIG  IV  L +  + +   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L++EYGGLDVL+NNAGIAFK     PF  QAEVT+ TNF  T  +C E +P++K   R+VN+SSMMS+  LK  S EL ++F  E +T  EL   M+ F +  K+   + +GWP  AYG++K+ VT ++ I    L+E+ + D  KIL+N CCPG+V TDM+      +  EGA+TP YLA LP+  E P+G+F+  + V +W
Sbjct:    1 MKSGIRVALVTGSNKGIGLAIVRDLCRLFSGE---VVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRTLRDFLLKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNISSMMSLRALKSCSPELQQKFRSETITEEELVGLMNKFAEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGD--KILLNACCPGWVRTDMAGPSATKSPEEGAETPVYLALLPLDAEGPHGQFVMEKRVEQW 277
[Close]
BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Match: sp|Q8K354|CBR3_MOUSE (Carbonyl reductase [NADPH] 3 OS=Mus musculus OX=10090 GN=Cbr3 PE=1 SV=1)

HSP 1 Score: 243.432 bits (620), Expect = 1.937e-78
Identity = 120/280 (42.86%), Postives = 178/280 (63.57%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRF-LEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEY--RNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            M++  +V LVTG+NKGIG  I   L +  + D   + LTAR+   G   + +L+ +G+  +FHQLDI   +S + L+D+L +EYGGL+VL+NNAGIAF+ D   PF  QAEVTL TNF  T  +C E +PI+K + R+VN+SS+  +  L+    +L ++F  + +T  +L + M  FV+  K +  E +GWP  AYG+SKL VT +T ILA +   +  + +IL+N CCPG+V TDM+  +G  T+ EGA+TP YLA LP     P+G+ + ++ V  W
Sbjct:    1 MSSCSRVALVTGANKGIGFAITRDLCRKFSGD---VVLTARDEARGRAAVQQLQAEGLSPRFHQLDIDDPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTPFDIQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNISSLQGLKALENCREDLQEKFRCDTLTEVDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKADRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQTW 277
[Close]
BLAST of Carbonyl reductase 1 vs. TrEMBL
Match: A0A2H1BV09 (Oxidoreductase, short chain dehydrogenase/reductase family protein OS=Fasciola hepatica OX=6192 GN=D915_15041 PE=4 SV=1)

HSP 1 Score: 325.865 bits (834), Expect = 2.561e-108
Identity = 160/275 (58.18%), Postives = 198/275 (72.00%), Query Frame = 1 
Query:   34 MKVVLVTGSNKGIGKGIVETLFKTVN-ADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEY-GGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            MKV  VTGSNKGIGK IVE L   +    EW IYLTARN ELG ++ SEL+ KG+ VKFHQLDIG   SRK+   +L  +Y  G+++ INNAGIA+KN+STAPF EQA VTL TNF DTL    EFIP+L  +AR+VNVSSM+S M L+KL  ELYK+F  PMT+ ++Q+  HDF++ A+       GWP  AYG+SKL +TK +YIL E+   D R I+IN CCPGYVDTDM+SHKG  T  +GADTP YLATLP+G + P  EF+S+R + KW
Sbjct:    1 MKVAFVTGSNKGIGKAIVEKLADALGPTGEWDIYLTARNEELGKQSWSELQNKGLKVKFHQLDIGDPNSRKNFLQFLKTQYPDGINIAINNAGIAYKNNSTAPFGEQARVTLQTNFFDTLTFTEEFIPLLAKDARVVNVSSMVSHMALEKLGEELYKKFTSPMTLEDVQSLAHDFIRHAENGDHGENGWPNTAYGVSKLCLTKASYILGEQLAKDPRNIVINSCCPGYVDTDMTSHKGTKTPEQGADTPFYLATLPVGVKEPINEFVSDRQIRKW 275
[Close]
BLAST of Carbonyl reductase 1 vs. TrEMBL
Match: A0A504YXL4 (Carbonyl reductase OS=Fasciola gigantica OX=46835 GN=FGIG_01635 PE=4 SV=1)

HSP 1 Score: 325.094 bits (832), Expect = 4.824e-108
Identity = 160/275 (58.18%), Postives = 197/275 (71.64%), Query Frame = 1 
Query:   34 MKVVLVTGSNKGIGKGIVETLFKTVN-ADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEY-GGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            MKV  VTGSNKGIGK IVE L   +    EW IYLTARN ELG +++SEL+ KG+ VKFHQLDIG   SRK    +L  +Y  G+++ INNAGIA+KN+STAPF EQA VTL TN  DTL    EFIP+L  +AR+VNVSSM+S M L+KL  ELYK+F  PMT+ ++Q+  HDF++ A+       GWP  AYG+SKL +TK +YIL E+   D R I+IN CCPGYVDTDMSSHKG  T  +GADTP YLATLP+G + P  EF+S+R + KW
Sbjct:    1 MKVAFVTGSNKGIGKAIVEKLADALGPTGEWDIYLTARNEELGKQSLSELQNKGLKVKFHQLDIGDPNSRKKFLQFLKTQYPDGINIAINNAGIAYKNNSTAPFGEQARVTLQTNLFDTLTFTEEFIPLLAKDARVVNVSSMVSHMALEKLGEELYKKFTSPMTLEDVQSLAHDFIRHAENGDHVKNGWPNTAYGVSKLCLTKASYILGEQLAKDPRNIVINSCCPGYVDTDMSSHKGTKTPEQGADTPFYLATLPVGVKEPINEFVSDRQIRKW 275
[Close]
BLAST of Carbonyl reductase 1 vs. TrEMBL
Match: A0A0X3PFD5 (Carbonyl reductase [NADPH] 1 (Fragment) OS=Schistocephalus solidus OX=70667 GN=CBR1 PE=3 SV=1)

HSP 1 Score: 325.094 bits (832), Expect = 7.971e-108
Identity = 154/279 (55.20%), Postives = 204/279 (73.12%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNA-DEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEY-GGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            ++ +MKV +VTG+NKG+G GIVE L K +    +W +YLTARN  LG + + E   +G+ VKFHQLDI  +KSR  L DY+   Y  G+++LINNAGIA+K DS APF EQA+VTL TN+  TL+MC  F+P++  N+RLVNVSS+MSV+TLKKL  ELY++F++PMT+ +L + MHDF++ A    L   GWP+ AYG+SKL +TK T+ILAE+ ++D R+ILIN CCPGYV+TDM+SHKG  TI EGA TP YLATLP     PYG+ +S    + W
Sbjct:   12 LSVNMKVAIVTGANKGVGHGIVERLIKCLTPPSDWHVYLTARNVSLGHEAVDEFVKRGLPVKFHQLDITDQKSRDKLADYVKSNYPDGINILINNAGIAYKTDSNAPFGEQAQVTLATNYFATLEMCNTFLPLMAKNSRLVNVSSIMSVVTLKKLGDELYEKFVKPMTIEQLNDLMHDFIRRAASGDLASAGWPQMAYGVSKLGLTKATFILAEQLKDDPRRILINACCPGYVNTDMTSHKGTKTILEGAVTPVYLATLPEDATEPYGQMISECKPMDW 290
[Close]
BLAST of Carbonyl reductase 1 vs. TrEMBL
Match: A0A267FZP2 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig027870g2 PE=3 SV=1)

HSP 1 Score: 310.457 bits (794), Expect = 3.231e-102
Identity = 149/283 (52.65%), Postives = 198/283 (69.96%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE*ELEF 870
            MA+++KV +VTGSNKGIG  IVE L K + +  W +Y+T+R+   G   +S+L+ +G+  +FHQLDI  ++S   L  YL   YGGLD+L+NNAGIA+K DSTAPF+EQAEVT+ TNF  TL++C    P+LK +AR+V++ S +S M L K S EL K+  +PM++ E++  M DFV  AK  T++  GWP+ AYG+SK+ V  MTY  A + + D   I+INCCCPGYVDTDM+SHKG  TIYEGADTP YLATLP G + P GE L  R VV W  + +F
Sbjct:    2 MASALKVAVVTGSNKGIGFAIVEQLCKQLGS-SWAVYVTSRDEARGADALSQLKQRGVEPRFHQLDIDSQESVDRLAAYLKGTYGGLDILVNNAGIAYKGDSTAPFAEQAEVTIATNFWSTLRVCDALFPLLKPHARVVHLCSSVSDMALNKASPELQKKLTQPMSLDEVKQLMSDFVARAKAGTVQEAGWPQTAYGVSKVGVRLMTYAQARDVKGDD--IVINCCCPGYVDTDMTSHKGPKTIYEGADTPVYLATLPPGIKQPIGEHLYERKVVPWAVKPDF 281
[Close]
BLAST of Carbonyl reductase 1 vs. TrEMBL
Match: A0A4E0QVI4 (Carbonyl reductase OS=Fasciola hepatica OX=6192 GN=D915_010573 PE=4 SV=1)

HSP 1 Score: 309.686 bits (792), Expect = 5.186e-102
Identity = 155/275 (56.36%), Postives = 192/275 (69.82%), Query Frame = 1 
Query:   34 MKVVLVTGSNKGIGKGIVETLFKTVN-ADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEY-GGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            MKV  VTGSNKGIGK IVE L   +    EW IYLTARN ELG ++ SEL+ KG+ VKFHQLDIG   SRK+   +L  +Y  G+++ INNAGIA+KN+STAPF EQA VTL TNF DTL    EFIP+L  +AR      M+S M L+KL  ELYK+F  PMT+ ++Q+  HDF++ A+       GWP  AYG+SKL +TK +YIL E+   D R I+IN CCPGYVDTDM+SHKG  T  +GADTP YLATLP+G + P  EF+S+R + KW
Sbjct:    1 MKVAFVTGSNKGIGKAIVEKLADALGPTGEWDIYLTARNEELGKQSWSELQNKGLKVKFHQLDIGDPNSRKNFLQFLKTQYPDGINIAINNAGIAYKNNSTAPFGEQARVTLQTNFFDTLTFTEEFIPLLAKDAR------MVSHMALEKLGEELYKKFTSPMTLEDVQSLAHDFIRHAENGDHGENGWPNTAYGVSKLCLTKASYILGEQLAKDPRNIVINSCCPGYVDTDMTSHKGTKTPEQGADTPFYLATLPVGVKEPINEFVSDRQIRKW 269
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Match: cbr1l (carbonyl reductase [NADPH] 1-like [Source:NCBI gene;Acc:103044035])

HSP 1 Score: 239.58 bits (610), Expect = 6.444e-78
Identity = 130/278 (46.76%), Postives = 173/278 (62.23%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKT-VNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEP-MTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEY--RNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            S KV +VTG+NKGIG  +V  + +   + D   + LTAR+ +LG + + ++   G    FHQLDI  + S  +L+ +L   YGGLDVLINNAGIA+KN++  PF EQAEVT+ TNF  TL +C    PILK NAR+VNVSS +S  +L K S EL  +  +P +T  EL + M++FV AAK    E KGW   AYGISK+ VT ++ I A           IL+N C PG+V TDM+      T  EGA+TP YLA LP G + P+G FLS++ V +W
Sbjct:    2 SGKVAVVTGANKGIGLAVVRAVCEAGFDGD---VVLTARSEQLGREAVQQIRAAGHRAVFHQLDITSKSSALELQRFLKNTYGGLDVLINNAGIAYKNNAPEPFGEQAEVTMRTNFWGTLWVCQALFPILKPNARVVNVSSFVSKRSLDKCSPELQAKLRDPAITEEELCSLMNEFVAAAKRGDHESKGWANTAYGISKVGVTVLSMIQARTLTKTRAGEGILLNACNPGWVRTDMAGQSADKTPEEGAETPVYLALLPEGAKEPHGRFLSDKKVEEW 276
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Match: cbr1 (carbonyl reductase 1 [Source:NCBI gene;Acc:103025086])

HSP 1 Score: 237.269 bits (604), Expect = 4.450e-77
Identity = 127/278 (45.68%), Postives = 165/278 (59.35%), Query Frame = 1 
Query:   28 ASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLE-PMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRND--SRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            ++ +V LVTGSNKGIG  +V +L K  + D   ++LTAR+   G   +  L+G+G+   FHQLDI    S +  +D+   +YGG+DVLINNAGIAFK   T PF  QAEVTL TNF  T  MC EF+PI+K   R+VNVSS M  + L + S EL  RF    +T  EL   M  FVK A+E      GWP  AYG+SK  +T +T I A +   +     IL N CCPG+V TDM+      +  EGA T  YLA LP G + P+G+F+S + V  W
Sbjct:    2 SARRVALVTGSNKGIGLAVVRSLCKQFDGD---VFLTARDVGRGQAAVEGLKGEGLSALFHQLDINDPASVRTARDFFRTQYGGVDVLINNAGIAFKMADTTPFGTQAEVTLKTNFFATRDMCNEFLPIIKSGGRVVNVSSGMGSIALGRCSSELQARFRSNNITEEELVGLMESFVKKAQEGVHNQSGWPDTAYGVSKTGLTTLTRIQARKLTAERPGDGILCNACCPGWVRTDMAGPNATKSPDEGAITLVYLALLPPGAKEPHGQFVSEKKVQPW 276
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Match: cbr1l (carbonyl reductase [NADPH] 1-like [Source:NCBI gene;Acc:103044035])

HSP 1 Score: 236.884 bits (603), Expect = 7.740e-77
Identity = 129/278 (46.40%), Postives = 172/278 (61.87%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKT-VNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEP-MTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEY--RNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            S KV +VTG+NKGIG  +V  + +   + D   + LTAR+ +LG + + ++   G    FHQLDI  +    +L+ +L   YGGLDVLINNAGIA+KN++  PF EQAEVT+ TNF  TL +C    PILK NAR+VNVSS +S  +L K S EL  +  +P +T  EL + M++FV AAK    E KGW   AYGISK+ VT ++ I A           IL+N C PG+V TDM+      T  EGA+TP YLA LP G + P+G FLS++ V +W
Sbjct:    2 SGKVAVVTGANKGIGLAVVRAVCEAGFDGD---VVLTARSEQLGREAVQQIRAAGHRAVFHQLDITSKSIALELQRFLKNTYGGLDVLINNAGIAYKNNAPEPFGEQAEVTMRTNFWGTLWVCQALFPILKPNARVVNVSSFVSKRSLDKCSPELQAKLRDPAITEEELCSLMNEFVAAAKRGDHESKGWANTAYGISKVGVTVLSMIQARTLTKTRAGEGILLNACNPGWVRTDMAGQSADKTPEEGAETPVYLALLPEGAKEPHGRFLSDKKVEEW 276
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Match: cbr1 (carbonyl reductase 1 [Source:NCBI gene;Acc:103025086])

HSP 1 Score: 235.728 bits (600), Expect = 2.311e-76
Identity = 127/274 (46.35%), Postives = 162/274 (59.12%), Query Frame = 1 
Query:   40 VVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLE-PMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRND--SRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            V LVTGSNKGIG  +V +L K  + D   ++LTAR+   G   +  L+G+G+   FHQLDI    S +  +D+   +YGG+DVLINNAGIAFK   T PF  QAEVTL TNF  T  MC EF+PI+K   R+VNVSS M  + L + S EL  RF    +T  EL   M  FVK A+E      GWP  AYG+SK  +T +T I A +   +     IL N CCPG+V TDM+      +  EGA T  YLA LP G + P+G+F+S + V  W
Sbjct:    8 VALVTGSNKGIGLAVVRSLCKQFDGD---VFLTARDVGRGQAAVEGLKGEGLSALFHQLDINDPASVRTARDFFRTQYGGVDVLINNAGIAFKMADTTPFGTQAEVTLKTNFFATRDMCNEFLPIIKSGGRVVNVSSGMGSIALGRCSSELQARFRSNNITEEELVGLMESFVKKAQEGVHNQSGWPDTAYGVSKTGLTTLTRIQARKLTAERPGDGILCNACCPGWVRTDMAGPNATKSPDEGAITLVYLALLPPGAKEPHGQFVSEKKVQPW 278
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Match: cbr1l (carbonyl reductase [NADPH] 1-like [Source:NCBI gene;Acc:103044320])

HSP 1 Score: 228.409 bits (581), Expect = 1.749e-73
Identity = 129/277 (46.57%), Postives = 182/277 (65.70%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGI-HVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEP-MTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK---ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            KV +VTG+NKGIG  IV+ L K   + +  I LTARN +LG++ + +++ +G  +V +H+LDI  + S  +LK +L + YGGLDVL+NNAG+AFK D+T PF EQAEVT+ TNF  TL +C   +PILK NAR+VNVSS +S  TL K S EL  +F    ++  EL   M +FV AA+    E +GWP  AYG +K+ VT ++ I A    N++R    I++N CCPG+V TDM+  K   +  EGA+TP YLA LP G + P+G+ + ++ V +W
Sbjct:    4 KVAVVTGANKGIGLAIVKGLCKAGYSGD--ILLTARNEKLGLEALEKVKAEGFKNVLYHRLDICDQGSCLELKKFLEKNYGGLDVLVNNAGMAFKVDATEPFGEQAEVTMRTNFWGTLWVCHALLPILKPNARVVNVSSFVSKRTLDKCSPELQAKFRSTELSEEELCLLMGEFVSAAQSGDHEAQGWPNSAYGTTKIGVTVLSRIQA-RVLNETRPADGIILNACCPGWVRTDMAGPKAPKSPEEGAETPVYLAMLPEGVKEPHGQLVWDKTVQEW 277
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Sea Lamprey
Match: cbr1 (carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030902-2])

HSP 1 Score: 194.512 bits (493), Expect = 5.815e-61
Identity = 117/279 (41.94%), Postives = 159/279 (56.99%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELG---MKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFK-NDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLE-PMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRND--SRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            KV +VTG+NKGIG  + + L      D   I LTARN E G   ++ +S L        FHQLDI  +KS      ++ ++YGG+D+LINNAGIAFK    T PF  QAEVT+ TN+  TL +    + +++   R+VNVSSM S   L   S EL  +F    +T  EL   M+ FV+ AK+   +  GW   AYG+SK+ VT M+ I A E   +  +  IL+N CCPG+V TDM+  K   +  EGA+TP +LA LP G   P+G F+S +    W
Sbjct:    5 KVAVVTGANKGIGLAVAKGLCGKWTGD---IVLTARNEENGQRALQALSTLTHGDQEAVFHQLDITDKKSIDSFAGFVREKYGGIDILINNAGIAFKVVADTTPFGTQAEVTMQTNYFGTLAVSKVLLKLVRPGGRVVNVSSMQSKRALAGCSAELQAQFRSETITEEELTELMNRFVEDAKQGRHQDNGWANSAYGVSKIGVTVMSLIHARELSRNRPNDNILLNACCPGWVRTDMAGPKAPKSPEEGAETPLFLALLPPGAGEPHGRFVSEKQAEPW 280
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Sea Lamprey
Match: dhrs1 (dehydrogenase/reductase (SDR family) member 1 [Source:ZFIN;Acc:ZDB-GENE-030616-591])

HSP 1 Score: 48.521 bits (114), Expect = 8.472e-7
Identity = 38/115 (33.04%), Postives = 58/115 (50.43%), Query Frame = 1 
Query:   22 MAASM--KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGG-LDVLINNAGIAFKNDSTA---PFSEQ 348
            MA S+  +V +VTG+++GIGKGI   L +        +Y+T RN E   +   E+E +G        D   E+  + L + + +E  G LD+L+NNA    K  +     PF EQ
Sbjct:    1 MAGSLSGQVCIVTGASRGIGKGIALQLAEAGAT----VYITGRNQETLRQAAEEVEARGGRCVPVSCDSTKEEEVRALFERVRREQKGRLDILVNNAYAGVKVSAQGIGKPFWEQ 111
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Sea Lamprey
Match: dhrs1 (dehydrogenase/reductase (SDR family) member 1 [Source:ZFIN;Acc:ZDB-GENE-030616-591])

HSP 1 Score: 47.3654 bits (111), Expect = 1.610e-6
Identity = 38/115 (33.04%), Postives = 58/115 (50.43%), Query Frame = 1 
Query:   22 MAASM--KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGG-LDVLINNAGIAFKNDSTA---PFSEQ 348
            MA S+  +V +VTG+++GIGKGI   L +        +Y+T RN E   +   E+E +G        D   E+  + L + + +E  G LD+L+NNA    K   +    PF EQ
Sbjct:    1 MAGSLSGQVCIVTGASRGIGKGIALQLAEAGAT----VYITGRNQETLRQAAEEVEARGGRCVPVSCDSTKEEEVRTLFERVRREQKGRLDILVNNAYAGVKTVFSGIGKPFWEQ 111
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BLAST of Carbonyl reductase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001758.1 (pep scaffold:Pmarinus_7.0:GL479572:17545:25983:-1 gene:ENSPMAG00000001590.1 transcript:ENSPMAT00000001758.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.595 bits (109), Expect = 2.931e-6
Identity = 71/285 (24.91%), Postives = 113/285 (39.65%), Query Frame = 1 
Query:   34 MKVVLVTGSNKGIGKGIVETLF-KTVNADEWIIYLTAR-NPELGMKTISELEGKGIHVKFHQLDI----GCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTL-GTNFTDTLKMCLEFIPILK----LNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNR-NVVKW 852
            +  VLVTG+N+G+G GIV  L  +   A    I+ T R   E   K +  L      +   ++DI      E++ + + + + +E  GL++L+NNAG   +  S    S  + +    TN      +   F+P+L      N +L       +V+ +   +G          ++S +    H             K +P   Y  SK A+  +   LAEE +     IL     PG+V T M   +  + I E       L  +   TE   G FL  R   V W
Sbjct:    6 LNSVLVTGANRGLGLGIVHRLLQQQQQASPRFIFATCRCTDEQSAKELRNLAEHHASLLVVEMDITDRASVERAVRVVDEAVGEE--GLNLLVNNAG-TLQTGSLGSLSADSMLQCYHTNAVAPAILTEAFLPLLNRAADFNVKLPMGCQKAAVVNVSSEAG----------SISSVPGNFHI-----------SKVYP---YRASKAALNMLIRCLAEELKEQG--ILCVALHPGWVRTRMGGSRAQIGIEE--SITGILGVMACLTEKDNGSFLDWRGQTVPW 259
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Yeast
Match: IRC24 (Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci [Source:SGD;Acc:S000001475])

HSP 1 Score: 61.2326 bits (147), Expect = 2.086e-11
Identity = 60/235 (25.53%), Postives = 102/235 (43.40%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGI-----AFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDM 726
            KV+L+TG+++GIG  +V+T+ +    DE I+Y  AR  E G++++    G    V +  LDI      + L + + Q++G LD ++ NAG+     +    ++    +Q E     NF   + +    +P+LK +  + N+  + S  ++K                                    + GW   AYG SK A+      +A E  +D  K+   C  PG VDT M
Sbjct:    3 KVILITGASRGIGLQLVKTVIE--EDDECIVYGVART-EAGLQSLQREYGADKFV-YRVLDITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPFVGNIVFVSSGASVKP-----------------------------------YNGW--SAYGCSKAALNHFAMDIASEEPSD--KVRAVCIAPGVVDTQM 194
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BLAST of Carbonyl reductase 1 vs. Ensembl Yeast
Match: YMR226C (NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004839])

HSP 1 Score: 55.4546 bits (132), Expect = 1.848e-9
Identity = 46/145 (31.72%), Postives = 69/145 (47.59%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELG--MKTI-SELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFS-EQAEVTLGTNFTDTLKMCLEFIPIL--KLNARLVNVSSM 453
            K VL+TG++ GIGK       +  N D  +I    R  +L    KTI  E     +HV   QLDI   +  K   + L QE+  +D+L+NNAG A  +D     + E  +    TN T  + +    +PI   K +  +VN+ S+
Sbjct:   14 KTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVA--QLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIFQAKNSGDIVNLGSI 156
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Yeast
Match: YIR035C_mRNA (Putative cytoplasmic short-chain dehydrogenase/reductase [Source:SGD;Acc:S000001474])

HSP 1 Score: 48.1358 bits (113), Expect = 4.817e-7
Identity = 65/240 (27.08%), Postives = 96/240 (40.00%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQL--DIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGT-------NFTDTLKMCLEFIPIL-KLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDM 726
            KV+LVTG ++GIGK IV+ LF +++ D  ++Y  AR+ E  +K + E  G     +F  +  DI  +   K L +  V+ +G +D L+ NAG+        P     E+ +         NF   + +    +P L K N  +V VSS    M                                          W   AYG SK A+      LA    N+ R++      PG VDTDM
Sbjct:    3 KVILVTGVSRGIGKSIVDVLF-SLDKDT-VVYGVARS-EAPLKKLKEKYGD----RFFYVVGDITEDSVLKQLVNAAVKGHGKIDSLVANAGV------LEPVQNVNEIDVNAWKKLYDINFFSIVSLVGIALPELKKTNGNVVFVSSDACNMYFSS--------------------------------------W--GAYGSSKAALNHFAMTLA----NEERQVKAIAVAPGIVDTDM 185
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Match: EDO49544 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGK5])

HSP 1 Score: 254.603 bits (649), Expect = 2.610e-84
Identity = 141/281 (50.18%), Postives = 182/281 (64.77%), Query Frame = 1 
Query:   22 MAAS-MKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYK-RFLEP-MTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRK-ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            MAAS  +V +VTGSNKGIG  IV  L K  +     + LTARN  LG + + +L+ +G++  FHQLDI  ++S   L+DYL   Y GLD+LINNAGIA+K  S APFSEQAEVT  TNFT TL +C    P+L+ +AR+VNV+S+  +  LK +  E  K +F  P +T S L   + +F+   K    + KGW   AYG+SK+AV  +T + A +   D R+ IL+NCCCPGYVDTDMSSHKGHLTI +GA+TP Y A LP G     GEF S + VV W
Sbjct:    1 MAASPSRVAVVTGSNKGIGFAIVRGLCKQFSG---TVILTARNENLGKEAVDKLKEEGLNPVFHQLDITSQESINKLRDYLSSTYKGLDLLINNAGIAYKGASIAPFSEQAEVTARTNFTGTLNICDTLFPLLRPHARVVNVASLAGL--LKIIPSEAIKAKFTSPSLTQSGLVGLVEEFISDVKAGVHKEKGWSNSAYGMSKVAVIALTKVQARQMEKDPRQDILVNCCCPGYVDTDMSSHKGHLTIDQGAETPIYCALLPEGCGHS-GEFFSQKKVVGW 275
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Match: EDO37582 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF98])

HSP 1 Score: 159.844 bits (403), Expect = 1.699e-47
Identity = 97/269 (36.06%), Postives = 148/269 (55.02%), Query Frame = 1 
Query:   49 VTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEP-MTMSELQNYMHDFVKAAKEDTLEHKGWPKQ-------AYGISKLAVTKMTYILAEEYRNDSRK-ILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFL 828
            VTG N+GIG  +V+ L +  + +   I LTAR+ E G      L   G  V++H+LD+    S  +L  ++ ++YGGLD+L+NNAGI  K  S   ++ +AE  + TNF   L +     P+LK  AR+VNVSS M   +LK +   L  +F+ P +T+ +  N M  +++  K   +   GWP +       AY +SKL VT +T ILA + + D R+ IL+N  CPG+  TD+       +  +GA++   LA LP GT  P G+ +
Sbjct:    1 VTGGNRGIGYCVVQQLVQQFDGN---IILTARSDEQGEAACRSLNVGG-RVEYHKLDVTSNDSIHELTLHVQEKYGGLDILVNNAGILKKESSGTSYARKAEDCVKTNFFGMLDVYNSMYPLLKEQARIVNVSSTMG--SLKIVHPSLALQFISPKLTVRQCVNLMQAYIRDVKNGRVAENGWPVEKLKVHNPAYSVSKLGVTALTSILARQLQRDGREGILVNAVCPGWCRTDIGGPCAPRSADKGAESVVQLALLPQGTSNPNGQLV 263
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Match: EDO37490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFM0])

HSP 1 Score: 61.2326 bits (147), Expect = 5.741e-11
Identity = 49/146 (33.56%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFH-QLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQA-EVTLGTNFTDTLKMCLEFIPIL-KLNARLVNVSSMMSVM 465
            KV +VTG +KGIG+G+V    K   A   +++  AR  E G K   E+   G    F  Q D+  E+  K++ D  +++YG LD LINNAG      S    S Q  E     N      MC   +P L K    ++N+SS+++++
Sbjct:   13 KVTIVTGGSKGIGEGVVREFVK---AGSKVVFC-ARGVEAGKKLEQEVNSTGPGESFFIQCDVTKEEDLKNVVDIAIEKYGQLDCLINNAGTHPDATSIDDTSVQDFENLFKLNVVSYFIMCKRSLPHLRKTKGNIINMSSLVALI 154
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Match: EDO35580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SL51])

HSP 1 Score: 58.9214 bits (141), Expect = 1.554e-10
Identity = 53/156 (33.97%), Postives = 78/156 (50.00%), Query Frame = 1 
Query:   22 MAASM---KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGI-HVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGI-----AFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPIL-KLNARLVNVSSMMS 459
            MAA+    KV +VTG +KGIG+GIV    K   A   +++  AR  E G+   +EL   G     F   D+  E   K++ D  V++YG LD LINNAG      +  + S     +  EV L + F     MC   +P L K    ++N+SS+++
Sbjct:    1 MAATRYQDKVTIVTGGSKGIGEGIVREFVK---AGSKVVF-CARGVESGLLLENELNASGPGQAMFIPCDVSKEGDLKNVVDRTVEKYGRLDCLINNAGRHPCHKSIDDTSVNELRDLLEVNLVSYFL----MCKFALPHLRKTQGNIINLSSLVA 148
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Match: EDO42776 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0P8])

HSP 1 Score: 52.7582 bits (125), Expect = 5.277e-8
Identity = 61/231 (26.41%), Postives = 107/231 (46.32%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADE-WIIYLTARN---PELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLN--ARLVNVSSMMSVM--------TLKKLSGELYKRFLEPM--------TMSELQNYMHDFVKAAK--EDTLEHKGWPKQAYGISKLAVTKMTYIL 651
            S +VVLVTG + GIG  +   L  + +AD+ + +Y T RN    +  ++  S + G  +++K  +LD+  ++S K +   +V++ G +DVL+NNAGI          ++        N    ++M    IP +K      +VN+ S++ V+           K + E Y   + P+        T+ E      +F   AK   D ++  G  +Q   + K A+TKM + L
Sbjct:   35 SQRVVLVTGCSSGIGLALAVLL--SHDADKRFKVYATMRNLVKKDALLEKCSGVVGDLLNIK--ELDVCSDESVKAVVAEIVEKEGRIDVLVNNAGIGLFCVPECATTDAISKVFEPNVYGLMRMTNAVIPHMKKQRAGHVVNIGSVLGVVGTPFSEIYCASKFAVEGYAEAMAPVLGKFNIKTTIIEPGPVATNFASNAKAIRDEVDISGTDEQTQALLKSALTKMYHSL 261
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Match: cbr1 (carbonyl reductase 1 [Source:NCBI gene;Acc:100125494])

HSP 1 Score: 221.09 bits (562), Expect = 4.148e-70
Identity = 122/279 (43.73%), Postives = 161/279 (57.71%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFL-EPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILA----EEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKW 852
            S +V +VTG NKGIG  IV  L +    D   +YLTAR+   G   ++ L  +G+   F QLDI    S      +  ++YGG+DVLINNA IAFK   T PF+ QAE TL TNF  T  +   F+P++K   R+VNVSS +S  TL + S EL +RF  E ++  EL   M  FV  AK    +  GWP+ AYG+SK  +T ++ ILA    +E  ND   IL+N CCPG+V TDM+      +  EGA TP YLA LP G   P+G+F+S + V  W
Sbjct:   51 STRVAVVTGGNKGIGLAIVRALCREFQGD---VYLTARDVGRGQAAVASLSSEGLKSSFQQLDINDVDSISTAAAFFKEKYGGVDVLINNAAIAFKVADTTPFAVQAEETLKTNFFATRDVLTAFMPLIKAGGRVVNVSSFVSCRTLNQCSPELQQRFRSEDISEEELAGLMQRFVDKAKAGQHKQDGWPEMAYGVSKTGLTVLSMILARRLSKERPNDG--ILLNACCPGWVRTDMAGPNAPKSPEEGAVTPVYLALLPPGATEPHGKFVSEKEVQPW 324
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BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Match: si:dkey-12e7.4 (C-factor [Source:NCBI gene;Acc:101175234])

HSP 1 Score: 55.8398 bits (133), Expect = 9.799e-9
Identity = 74/268 (27.61%), Postives = 121/268 (45.15%), Query Frame = 1 
Query:   43 VLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDY--LVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMS--ELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIG-TETPYGEFLS 831
            VLVTG+N+G+G  +VE+L     +   II  T RN  +  KT+ EL GK  ++    LD+  ++S +   +   L+ +  GL+ LINNAGI    D  +  +E+      TN    L +    +P+LK   R  +  +   VM +++ +       L  + ++  EL N                K +P   Y  SK A+  ++  +A +   +   IL     PG+V TDM      L+  E   +   + +L  G TE  +G FL+
Sbjct:   13 VLVTGANRGLGLQMVESLASGDFSPRKIIA-TTRNVAVA-KTLQELAGKYSNIHVLPLDVVSQESIEKCAEEVDLLLQGDGLNCLINNAGINVLADFHSVTAEKMIENFHTNAVAPLMITKALLPLLK---RAADGKAADGVMGIQRAAVINITALLGSVELNWGELANTC--------------KWYP---YRTSKCALNMVSRCMAVDL--EPEGILCTAIHPGWVRTDMGGTMAPLSPEESVSS---VLSLTGGLTEKDHGSFLN 253
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BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Match: ENSORLT00000023326.2 (C-factor [Source:NCBI gene;Acc:101158176])

HSP 1 Score: 55.0694 bits (131), Expect = 1.771e-8
Identity = 71/274 (25.91%), Postives = 108/274 (39.42%), Query Frame = 1 
Query:   43 VLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYG--GLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKL-----------NARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEF 825
            VL+TG ++GIG  +V+ L ++ +    II  TARNP  G   + EL      V    LD+  E+S     + +    G  GL+ LINNA +   +   +   E        N    L +   F+P+L+             A +VN+SS++  ++L       +K +                                 AYG SK A+  ++  LA +       IL     PG+V TDM      LT+ E       L+TL   TE  +G F
Sbjct:    7 VLITGCSRGIGLQLVKQLSESSSRPANIIA-TARNPA-GSAALQELSRTCPGVHAVTLDVCSEQSIFSAVEEVQFIVGNQGLNCLINNAAVGSSSSINSVTREAMMRAFQVNSVAPLFVTKAFLPLLQTAAARSTGMGVHRAAVVNISSILGSISLNCGDSATFKSY---------------------------------AYGTSKAALNMVSRCLAADL--GPVGILCVSLHPGWVKTDMGGPHADLTVEESVSE--ILSTLVSFTEQDHGGF 241
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Match: hpgd (15-hydroxyprostaglandin dehydrogenase [Source:NCBI gene;Acc:101171390])

HSP 1 Score: 54.299 bits (129), Expect = 3.986e-8
Identity = 60/238 (25.21%), Postives = 100/238 (42.02%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGK--GIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQ-AYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDM 726
            M+   +V LVTG  +GIG+ +VE L ++  A   ++ +   N   G    SEL+ +  G +  F Q D+    + +D     V+ +G LD++INNAGI   N+      +  E T+  N T  +K                      + + L+ +S E  KR    + +S +  ++H                P Q  Y  +K  V   T  +A+     +  + IN  CP +VDT +
Sbjct:    1 MSVMGRVALVTGGAQGIGRAVVEALLRS-GAKVSVVDI---NQSCGDVCKSELDAEFGGDNCAFIQCDVTDGHALRDAFQKTVELFGRLDIVINNAGI--NNE------KNWEKTIDVNLTSLIK---------------------GTYLGLEHMSREHGKRGGTIVNVSSMAAFLHS---------------PHQPVYTATKHGVIGFTRAMADASILGNYGVRINALCPAFVDTPL 190
[Close]
BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Match: zgc:112332 (retinol dehydrogenase 12-like [Source:NCBI gene;Acc:111946613])

HSP 1 Score: 52.7582 bits (125), Expect = 1.482e-7
Identity = 76/286 (26.57%), Postives = 118/286 (41.26%), Query Frame = 1 
Query:   37 KVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISEL-EGKGI-HVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQA---EVTLGTNFTDTLKMCLEFIPILKLN--ARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHL-------------TIYEGADTPCYLATLPIGTETPYGEFLSN 834
            K V++TG+N GIGK     L +        I +  R+ E   +  +++ E  G  ++   +LD+   KS K   + + +E   ++VLINNAGI        P+S+ A   E+ LG N      +    + ++K +  AR+V V+S+    T  +L                      D   A   DT+       +AYG SKLA       LA+  R  +  + +    PG V +D+  H+                T  EGA T  Y A  P G E   GE+ S+
Sbjct:   20 KTVIITGANTGIGKETARDLARRGAR----IIMACRDLERAEEARTDIFEDTGNENMVIRKLDLSDTKSIKAFAELINKEEKQVNVLINNAGIMM-----CPYSKTADGFEMQLGVNHLGHFLLTYLLLDLMKRSAPARIVVVASVAHTWTGLRLD---------------------DINSAKSYDTM-------KAYGQSKLANVMFARSLAK--RLKATGVSVFSLHPGVVQSDLWRHQHQCIQVAVKIFRVFTKTPVEGAQTTIYCAVEP-GLEILSGEYFSD 265
[Close]
BLAST of Carbonyl reductase 1 vs. Planmine SMEST
Match: SMESG000009833.1 (SMESG000009833.1)

HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0
Identity = 276/278 (99.28%), Postives = 276/278 (99.28%), Query Frame = 1 
Query:   22 MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE 855
            MAASMKVVLVTGSNKGIGKGIVETLFKTVNA EWIIYLTARNPE GMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE
Sbjct:    1 MAASMKVVLVTGSNKGIGKGIVETLFKTVNAAEWIIYLTARNPEFGMKTISELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTLKKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADTPCYLATLPIGTETPYGEFLSNRNVVKWE 278
[Close]
BLAST of Carbonyl reductase 1 vs. Planmine SMEST
Match: SMESG000056753.1 (SMESG000056753.1)

HSP 1 Score: 52.373 bits (124), Expect = 1.496e-7
Identity = 83/288 (28.82%), Postives = 116/288 (40.28%), Query Frame = 1 
Query:   31 SMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTISELEGKGIHVKF--HQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKNDSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKL--NARLVNVSSMMSVMTLKKLS-GELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWP-KQAYGISKLAVTKMTYILAEEYRNDSRKILINCCCPGYVDT-----DMSS----HKGHL-TIYEGADTPCYLATLPIGTETPYGEFLSNRNVV 846
            S KV L+TG+N G+GK   E L K        I++  R+ +   + + EL+      KF  H LD+              +    LD+LINNAG    ND T   S+  E+   TN   T  +    I  L    N R+V VSS    M L+KL   ++  + + P                        KG+    AY  +K    +   I+  E+     KI      PG+ DT      MSS    HK  L T+ +G+DT  +LA        P GEF  +R VV
Sbjct:   39 SEKVCLITGANSGLGKSCAEHLSKLGAK----IHMVCRDKKRAEEALEELKEHTKSDKFVLHLLDLSKPSDVYRFGKQFSESEEKLDILINNAGCMI-NDLTYN-SDGLEMNFVTNTLSTYLLSESLIESLNRSPNPRVVVVSS--GGMLLQKLDYSDVNFKIVGP------------------------KGFDGTMAYAQNK----RQQVIMTTEWSKKYPKIKFFSMHPGWADTPAVASSMSSFYEKHKSRLRTVDQGSDTIVWLAASEAAMSQPNGEFFQDRKVV 290
The following BLAST results are available for this feature:
BLAST of Carbonyl reductase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CBR13.277e-8145.74carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
CBR32.537e-7441.43carbonyl reductase 3 [Source:HGNC Symbol;Acc:HGNC:... [more]
CBR13.469e-3546.76carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
CBR11.527e-3447.37carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
CBR13.830e-3447.37carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
F20G2.16.523e-1431.35pep chromosome:WBcel235:V:13752267:13753580:-1 gen... [more]
C55A6.49.281e-1430.31pep chromosome:WBcel235:V:11516445:11517889:-1 gen... [more]
C55A6.74.416e-1325.40pep chromosome:WBcel235:V:11519335:11520530:-1 gen... [more]
C55A6.61.068e-1228.69pep chromosome:WBcel235:V:11513665:11514737:-1 gen... [more]
F20G2.21.004e-1026.52pep chromosome:WBcel235:V:13755011:13756409:-1 gen... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG112001.061e-1126.99gene:FBgn0034500 transcript:FBtr0086299[more]
CG112001.061e-1126.99gene:FBgn0034500 transcript:FBtr0086300[more]
CG112001.061e-1126.99gene:FBgn0034500 transcript:FBtr0344185[more]
CG36994.943e-1126.53gene:FBgn0040349 transcript:FBtr0070186[more]
CG73224.056e-933.56gene:FBgn0030968 transcript:FBtr0346018[more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbr13.222e-7747.29carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030... [more]
cbr13.222e-7747.29carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030... [more]
cbr1l1.158e-7647.67carbonyl reductase 1-like [Source:ZFIN;Acc:ZDB-GEN... [more]
si:dkey-12e7.48.299e-927.44si:dkey-12e7.4 [Source:ZFIN;Acc:ZDB-GENE-050419-83... [more]
dhrs121.634e-825.94dehydrogenase/reductase (SDR family) member 12 [So... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbr11.520e-8248.75carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc... [more]
cbr13.944e-8048.57carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc... [more]
cbr13.944e-8048.57carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc... [more]
cbr12.786e-7847.50carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc... [more]
cbr14.444e-7847.50carbonyl reductase 1, gene 1 [Source:NCBI gene;Acc... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cbr14.559e-8145.00carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88... [more]
Cbr32.769e-7942.86carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:13... [more]
Gm56789.617e-7643.57predicted gene 5678 [Source:MGI Symbol;Acc:MGI:364... [more]
Cbr11.984e-3647.37carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88... [more]
Cbr32.169e-2345.00carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:13... [more]
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BLAST of Carbonyl reductase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5RCU5|CBR1_PONAB5.425e-8145.74Carbonyl reductase [NADPH] 1 OS=Pongo abelii OX=96... [more]
sp|P16152|CBR1_HUMAN1.574e-8045.74Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=96... [more]
sp|P48758|CBR1_MOUSE3.189e-8045.00Carbonyl reductase [NADPH] 1 OS=Mus musculus OX=10... [more]
sp|Q8MI29|CBR1_MACFA1.240e-7944.33Carbonyl reductase [NADPH] 1 OS=Macaca fasciculari... [more]
sp|Q8K354|CBR3_MOUSE1.937e-7842.86Carbonyl reductase [NADPH] 3 OS=Mus musculus OX=10... [more]
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BLAST of Carbonyl reductase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2H1BV092.561e-10858.18Oxidoreductase, short chain dehydrogenase/reductas... [more]
A0A504YXL44.824e-10858.18Carbonyl reductase OS=Fasciola gigantica OX=46835 ... [more]
A0A0X3PFD57.971e-10855.20Carbonyl reductase [NADPH] 1 (Fragment) OS=Schisto... [more]
A0A267FZP23.231e-10252.65Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A4E0QVI45.186e-10256.36Carbonyl reductase OS=Fasciola hepatica OX=6192 GN... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbr1l6.444e-7846.76carbonyl reductase [NADPH] 1-like [Source:NCBI gen... [more]
cbr14.450e-7745.68carbonyl reductase 1 [Source:NCBI gene;Acc:1030250... [more]
cbr1l7.740e-7746.40carbonyl reductase [NADPH] 1-like [Source:NCBI gen... [more]
cbr12.311e-7646.35carbonyl reductase 1 [Source:NCBI gene;Acc:1030250... [more]
cbr1l1.749e-7346.57carbonyl reductase [NADPH] 1-like [Source:NCBI gen... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cbr15.815e-6141.94carbonyl reductase 1 [Source:ZFIN;Acc:ZDB-GENE-030... [more]
dhrs18.472e-733.04dehydrogenase/reductase (SDR family) member 1 [Sou... [more]
dhrs11.610e-633.04dehydrogenase/reductase (SDR family) member 1 [Sou... [more]
ENSPMAT00000001758.12.931e-624.91pep scaffold:Pmarinus_7.0:GL479572:17545:25983:-1 ... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3
Match NameE-valueIdentityDescription
IRC242.086e-1125.53Putative benzil reductase;(GFP)-fusion protein loc... [more]
YMR226C1.848e-931.72NADP(+)-dependent serine dehydrogenase and carbony... [more]
YIR035C_mRNA4.817e-727.08Putative cytoplasmic short-chain dehydrogenase/red... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO495442.610e-8450.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO375821.699e-4736.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374905.741e-1133.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO355801.554e-1033.97Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427765.277e-826.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Carbonyl reductase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cbr14.148e-7043.73carbonyl reductase 1 [Source:NCBI gene;Acc:1001254... [more]
si:dkey-12e7.49.799e-927.61C-factor [Source:NCBI gene;Acc:101175234][more]
ENSORLT00000023326.21.771e-825.91C-factor [Source:NCBI gene;Acc:101158176][more]
hpgd3.986e-825.2115-hydroxyprostaglandin dehydrogenase [Source:NCBI... [more]
zgc:1123321.482e-726.57retinol dehydrogenase 12-like [Source:NCBI gene;Ac... [more]
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BLAST of Carbonyl reductase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000009833.10.000e+099.28SMESG000009833.1[more]
SMESG000056753.11.496e-728.82SMESG000056753.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005862 ID=SMED30005862|Name=Carbonyl reductase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=937bp
TTTGTTTTTATCAATTAAAAGATGGCGGCATCTATGAAAGTTGTTTTAGT
CACAGGATCTAATAAAGGCATTGGTAAAGGCATAGTTGAAACACTATTTA
AAACTGTAAATGCTGATGAATGGATAATATATTTAACAGCAAGAAATCCC
GAGTTGGGAATGAAAACTATTAGTGAACTGGAAGGAAAAGGTATCCATGT
AAAGTTTCATCAACTTGACATAGGTTGTGAAAAAAGTCGTAAAGATCTTA
AAGATTATCTTGTACAGGAATATGGTGGTTTGGACGTTCTTATTAATAAT
GCCGGAATTGCTTTTAAAAATGACAGCACCGCTCCGTTTAGCGAACAAGC
TGAAGTGACTTTAGGAACAAACTTTACGGATACTTTGAAAATGTGCCTTG
AATTCATTCCAATTTTAAAATTAAACGCTAGACTAGTAAATGTATCCAGT
ATGATGAGTGTCATGACCCTGAAGAAGCTCAGTGGTGAATTGTACAAACG
TTTTCTAGAACCAATGACAATGAGTGAGCTTCAAAATTACATGCATGATT
TTGTCAAAGCTGCTAAAGAAGACACATTAGAACATAAAGGCTGGCCGAAA
CAAGCCTATGGAATTTCGAAATTGGCCGTTACTAAGATGACCTATATTTT
GGCAGAGGAATATAGAAATGATTCAAGAAAGATTCTGATTAATTGTTGCT
GTCCGGGCTATGTGGACACAGATATGAGTAGTCATAAAGGCCATTTGACT
ATTTATGAAGGTGCTGATACTCCCTGTTATTTGGCAACTTTGCCAATTGG
AACGGAAACTCCCTATGGTGAGTTTCTATCCAATAGGAACGTAGTGAAAT
GGGAATAAGAGTTAGAATTCTTAGCTTCTTGCCTTAGTTCATTTTGATAT
TTTAATAAAATTTTTGTTATCTTCAAAAAAAAAGATC
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protein sequence of SMED30005862-orf-1

>SMED30005862-orf-1 ID=SMED30005862-orf-1|Name=SMED30005862-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=279bp
MAASMKVVLVTGSNKGIGKGIVETLFKTVNADEWIIYLTARNPELGMKTI
SELEGKGIHVKFHQLDIGCEKSRKDLKDYLVQEYGGLDVLINNAGIAFKN
DSTAPFSEQAEVTLGTNFTDTLKMCLEFIPILKLNARLVNVSSMMSVMTL
KKLSGELYKRFLEPMTMSELQNYMHDFVKAAKEDTLEHKGWPKQAYGISK
LAVTKMTYILAEEYRNDSRKILINCCCPGYVDTDMSSHKGHLTIYEGADT
PCYLATLPIGTETPYGEFLSNRNVVKWE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036291NAD(P)-bd_dom_sf
IPR002347SDR_fam
IPR016040NAD(P)-bd_dom
Vocabulary: molecular function
TermDefinition
GO:0004090carbonyl reductase (NADPH) activity
GO:0016491oxidoreductase activity
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002347Short-chain dehydrogenase/reductase SDRPRINTSPR00081GDHRDHcoord: 130..146
score: 21.56
coord: 196..215
score: 32.89
coord: 85..96
score: 62.73
coord: 7..24
score: 44.22
coord: 219..236
score: 35.05
IPR002347Short-chain dehydrogenase/reductase SDRPRINTSPR00080SDRFAMILYcoord: 85..96
score: 61.83
coord: 136..144
score: 35.78
coord: 196..215
score: 33.09
IPR002347Short-chain dehydrogenase/reductase SDRPFAMPF00106adh_shortcoord: 194..238
e-value: 2.0E-7
score: 30.7
coord: 6..151
e-value: 3.7E-22
score: 78.7
NoneNo IPR availableGENE3DG3DSA:3.40.50.720coord: 4..278
e-value: 1.2E-69
score: 236.5
NoneNo IPR availablePANTHERPTHR43963FAMILY NOT NAMEDcoord: 2..277
NoneNo IPR availableCDDcd05324carb_red_PTCR-like_SDR_ccoord: 6..277
e-value: 9.32334E-84
score: 248.691
IPR036291NAD(P)-binding domain superfamilySUPERFAMILYSSF51735NAD(P)-binding Rossmann-fold domainscoord: 4..277