Homeobox domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30005805 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: NKX1-1 (NK1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:24975]) HSP 1 Score: 129.798 bits (325), Expect = 6.596e-34 Identity = 58/65 (89.23%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 258 KPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 322
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: NKX1-2 (NK1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:31652]) HSP 1 Score: 127.487 bits (319), Expect = 7.229e-34 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 162 KPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 226
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: GBX1 (gastrulation brain homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4185]) HSP 1 Score: 88.5817 bits (218), Expect = 2.827e-19 Identity = 39/63 (61.90%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 KSRR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 260 KSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAG 322
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: GBX2 (gastrulation brain homeobox 2 [Source:HGNC Symbol;Acc:HGNC:4186]) HSP 1 Score: 87.4261 bits (215), Expect = 5.186e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 246 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 308
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: MNX1 (motor neuron and pancreas homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4979]) HSP 1 Score: 81.6481 bits (200), Expect = 6.155e-18 Identity = 39/67 (58.21%), Postives = 50/67 (74.63%), Query Frame = 1 Query: 295 QSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKK 495 Q+ ++L K RR RTAFT +QL+ LE++FK +YLS +R +A SL LTE QVKIWFQNRR KWK+ Sbjct: 20 QAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKR 86
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-1 (Homeobox protein ceh-1 [Source:UniProtKB/Swiss-Prot;Acc:P53547]) HSP 1 Score: 124.02 bits (310), Expect = 1.644e-34 Identity = 67/125 (53.60%), Postives = 84/125 (67.20%), Query Frame = 1 Query: 208 DSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQN--SSKKTELS--LPQRP 570 + + +L+ R + S + + + +S KLK RRARTAFTYEQLV+LENKFK++RYLSV ERLNLA LQL+E QVKIWFQNRRTKWKK NPG D + Q SS +T++ LP P Sbjct: 2 NGFRVEDLLSEREKDSNSDEATHQKSPADGGKSSRKLKMRRARTAFTYEQLVALENKFKTSRYLSVVERLNLAIQLQLSETQVKIWFQNRRTKWKKHNPGQDANTPQTPPSSDETQIQPILPANP 126
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-31 (Homeobox protein ceh-31 [Source:UniProtKB/Swiss-Prot;Acc:Q22910]) HSP 1 Score: 84.7297 bits (208), Expect = 7.035e-19 Identity = 39/69 (56.52%), Postives = 52/69 (75.36%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ-NPGSDVHH 522 K+R+ART FT +QL LEN F+ +YLSV +R+ LAH + LT+ QVK W+QNRRTKWK+Q + G D+ H Sbjct: 93 KARKARTIFTDKQLQELENTFEKQKYLSVQDRMELAHRMGLTDTQVKTWYQNRRTKWKRQASVGMDLLH 161
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-30 (Homeobox protein ceh-30 [Source:UniProtKB/Swiss-Prot;Acc:Q22909]) HSP 1 Score: 83.9593 bits (206), Expect = 9.129e-19 Identity = 37/60 (61.67%), Postives = 48/60 (80.00%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 KSR+ART FT +QL LEN F+ +YLSV +R++LAH + LT+ QVK W+QNRRTKWK+Q Sbjct: 94 KSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTWYQNRRTKWKRQ 153
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-30 (Homeobox protein ceh-30 [Source:UniProtKB/Swiss-Prot;Acc:Q22909]) HSP 1 Score: 83.9593 bits (206), Expect = 9.129e-19 Identity = 37/60 (61.67%), Postives = 48/60 (80.00%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 KSR+ART FT +QL LEN F+ +YLSV +R++LAH + LT+ QVK W+QNRRTKWK+Q Sbjct: 94 KSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLTDTQVKTWYQNRRTKWKRQ 153
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: vab-15 (Homeobox protein vab-15 [Source:UniProtKB/Swiss-Prot;Acc:Q09604]) HSP 1 Score: 77.0258 bits (188), Expect = 2.510e-16 Identity = 35/57 (61.40%), Postives = 44/57 (77.19%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKK 495 R+ RT F+ +QL+SLE KF+S +YLS+ ER + SLQLTE QVKIWFQNRR K K+ Sbjct: 130 RKPRTPFSTQQLISLERKFQSKQYLSIAERAEFSASLQLTETQVKIWFQNRRAKSKR 186
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: slou (gene:FBgn0002941 transcript:FBtr0084123) HSP 1 Score: 129.413 bits (324), Expect = 4.052e-33 Identity = 59/64 (92.19%), Postives = 60/64 (93.75%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 546 RRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDV 609
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: slou (gene:FBgn0002941 transcript:FBtr0330389) HSP 1 Score: 129.028 bits (323), Expect = 5.569e-33 Identity = 59/64 (92.19%), Postives = 60/64 (93.75%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 546 RRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDV 609
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: lms (gene:FBgn0034520 transcript:FBtr0342702) HSP 1 Score: 83.1889 bits (204), Expect = 1.215e-17 Identity = 48/134 (35.82%), Postives = 71/134 (52.99%), Query Frame = 1 Query: 145 HPFQIDNLLSKTLDDEGSAFEDSYH--YSELVKCRVGEEYSWNSNSKSC--------------SPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 H F I+ +L+K ++FEDS C +G + + + SC + + N + +R RTAF+ Q+ +LE +F+ +YLSV +R LA LQLTE Q+KIWFQNRRTKWK++ Sbjct: 12 HSFSIEQILAKPEMRSSTSFEDSVQDESGRGGNC-LGASRASSPATSSCLDDNMDDGKSDIDLASDDGNGLGDDRKKRPRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKRK 144
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: lms (gene:FBgn0034520 transcript:FBtr0342701) HSP 1 Score: 83.1889 bits (204), Expect = 1.215e-17 Identity = 48/134 (35.82%), Postives = 71/134 (52.99%), Query Frame = 1 Query: 145 HPFQIDNLLSKTLDDEGSAFEDSYH--YSELVKCRVGEEYSWNSNSKSC--------------SPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 H F I+ +L+K ++FEDS C +G + + + SC + + N + +R RTAF+ Q+ +LE +F+ +YLSV +R LA LQLTE Q+KIWFQNRRTKWK++ Sbjct: 12 HSFSIEQILAKPEMRSSTSFEDSVQDESGRGGNC-LGASRASSPATSSCLDDNMDDGKSDIDLASDDGNGLGDDRKKRPRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKRK 144
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: B-H1 (gene:FBgn0011758 transcript:FBtr0074430) HSP 1 Score: 83.1889 bits (204), Expect = 2.210e-17 Identity = 38/64 (59.38%), Postives = 46/64 (71.88%), Query Frame = 1 Query: 307 SLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 L K R+ARTAFT QL +LE F+ +YLSV ER LAH L L++ QVK W+QNRRTKWK+Q Sbjct: 294 GLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQ 357
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: nkx1.2lb (NK1 transcription factor related 2-like,b [Source:ZFIN;Acc:ZDB-GENE-040615-2]) HSP 1 Score: 127.872 bits (320), Expect = 7.245e-34 Identity = 59/66 (89.39%), Postives = 61/66 (92.42%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 199 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT 264
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: nkx1.2la (NK1 transcription factor related 2-like,a [Source:ZFIN;Acc:ZDB-GENE-040615-1]) HSP 1 Score: 122.865 bits (307), Expect = 1.149e-32 Identity = 56/63 (88.89%), Postives = 59/63 (93.65%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG Sbjct: 140 KPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPG 202
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: pnx (posterior neuron-specific homeobox [Source:NCBI gene;Acc:352939]) HSP 1 Score: 87.0409 bits (214), Expect = 3.344e-20 Identity = 45/75 (60.00%), Postives = 56/75 (74.67%), Query Frame = 1 Query: 286 SPNQSNNSL-KLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 +PN +N S K+KS+R RTAFT +QL LE F+S+ YLSV ER +A +L L+E QVKIWFQNRRTKWKK+ G Sbjct: 54 APNIANASAAKVKSKRIRTAFTLDQLRILERSFQSSHYLSVFERHCIASALGLSETQVKIWFQNRRTKWKKELDG 128
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: gbx1 (gastrulation brain homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-020117-2]) HSP 1 Score: 88.1965 bits (217), Expect = 1.287e-19 Identity = 39/63 (61.90%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 KSRR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 213 KSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAG 275
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: gbx2 (gastrulation brain homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-020509-2]) HSP 1 Score: 87.0409 bits (214), Expect = 4.771e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 240 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 302
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: rpgrip1 (RPGR interacting protein 1 [Source:Xenbase;Acc:XB-GENE-1007974]) HSP 1 Score: 129.413 bits (324), Expect = 7.449e-34 Identity = 59/66 (89.39%), Postives = 61/66 (92.42%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 256 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT 321
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: pmp2 (peripheral myelin protein 2 [Source:Xenbase;Acc:XB-GENE-977969]) HSP 1 Score: 111.309 bits (277), Expect = 1.675e-28 Identity = 50/62 (80.65%), Postives = 57/62 (91.94%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNP 504 K RRARTAFTYEQLV+LE++F+S+RYLSVCERL+LA +L LTE QVKIWFQNRRTKWKKQ P Sbjct: 99 KPRRARTAFTYEQLVALESRFRSSRYLSVCERLSLALTLHLTETQVKIWFQNRRTKWKKQQP 160
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000053265.1 (gastrulation brain homeobox 2, gene 1 [Source:NCBI gene;Acc:100485559]) HSP 1 Score: 86.6557 bits (213), Expect = 8.672e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 238 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 300
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000050503.1 (NK3 homeobox 1 [Source:NCBI gene;Acc:100038192]) HSP 1 Score: 84.3445 bits (207), Expect = 8.837e-19 Identity = 58/166 (34.94%), Postives = 87/166 (52.41%), Query Frame = 1 Query: 127 DFSMPNHP---FQIDNLLS--------KTLD------DEGSAF------------EDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSS 537 D S+P P F I ++LS K+LD D+ S+ + S +E+ ++ +E ++ SP + LKL+ +R+R AF++ Q++ LE KF S +YLS ER LA SL+LTE QVKIWFQNRR K K++ +D+ + SS Sbjct: 8 DLSLPAKPLKSFLIQDILSHIGPGRKEKSLDSPKTDQDQDSSLGGKKENCTPEKQQSSSQPAEMHHSQMEDENVELDQAQPISPVEKK--LKLQQKRSRAAFSHSQVIELERKFSSQKYLSAPERAQLAKSLKLTETQVKIWFQNRRYKTKRKQLATDMEEVEKSS 171
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: gbx2.2 (gastrulation brain homeobox 2, gene 2 [Source:NCBI gene;Acc:496963]) HSP 1 Score: 85.5001 bits (210), Expect = 2.348e-18 Identity = 38/63 (60.32%), Postives = 48/63 (76.19%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH L+L+E+QVKIWFQNRR KWK+ G Sbjct: 238 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHVLKLSEVQVKIWFQNRRAKWKRVKAG 300
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Nkx1-1 (NK1 homeobox 1 [Source:MGI Symbol;Acc:MGI:109346]) HSP 1 Score: 131.339 bits (329), Expect = 8.662e-35 Identity = 58/65 (89.23%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 249 KPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 313
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Nkx1-2 (NK1 homeobox 2 [Source:MGI Symbol;Acc:MGI:104806]) HSP 1 Score: 127.487 bits (319), Expect = 4.799e-34 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 155 KPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 219
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Gbx1 (gastrulation brain homeobox 1 [Source:MGI Symbol;Acc:MGI:95667]) HSP 1 Score: 88.9669 bits (219), Expect = 1.998e-19 Identity = 39/63 (61.90%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 KSRR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 315 KSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAG 377
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Gbx2 (gastrulation brain homeobox 2 [Source:MGI Symbol;Acc:MGI:95668]) HSP 1 Score: 87.4261 bits (215), Expect = 3.775e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 246 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 308
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Mnx1 (motor neuron and pancreas homeobox 1 [Source:MGI Symbol;Acc:MGI:109160]) HSP 1 Score: 83.1889 bits (204), Expect = 2.022e-17 Identity = 39/68 (57.35%), Postives = 51/68 (75.00%), Query Frame = 1 Query: 292 NQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKK 495 +Q+ ++L K RR RTAFT +QL+ LE++FK +YLS +R +A SL LTE QVKIWFQNRR KWK+ Sbjct: 231 SQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKR 298
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q15270|NKX11_HUMAN (NK1 transcription factor-related protein 1 OS=Homo sapiens OX=9606 GN=NKX1-1 PE=2 SV=2) HSP 1 Score: 129.798 bits (325), Expect = 3.167e-33 Identity = 58/65 (89.23%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 258 KPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 322
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|P42580|NKX12_MOUSE (NK1 transcription factor-related protein 2 OS=Mus musculus OX=10090 GN=Nkx1-2 PE=1 SV=1) HSP 1 Score: 127.487 bits (319), Expect = 3.357e-33 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 155 KPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 219
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9UD57|NKX12_HUMAN (NK1 transcription factor-related protein 2 OS=Homo sapiens OX=9606 GN=NKX1-2 PE=2 SV=3) HSP 1 Score: 127.487 bits (319), Expect = 3.471e-33 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 162 KPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 226
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|P22807|SLOU_DROME (Homeobox protein slou OS=Drosophila melanogaster OX=7227 GN=slou PE=2 SV=1) HSP 1 Score: 129.413 bits (324), Expect = 4.062e-32 Identity = 59/64 (92.19%), Postives = 60/64 (93.75%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 546 RRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDV 609
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|P53547|HM01_CAEEL (Homeobox protein ceh-1 (Fragment) OS=Caenorhabditis elegans OX=6239 GN=ceh-1 PE=3 SV=1) HSP 1 Score: 117.857 bits (294), Expect = 1.548e-31 Identity = 60/86 (69.77%), Postives = 68/86 (79.07%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQN--SSKKTELS--LPQRP 570 RRARTAFTYEQLV+LENKFK++RYLSV ERLNLA LQL+E QVKIWFQNRRTKWKK NPG D + Q SS +T++ LP P Sbjct: 2 RRARTAFTYEQLVALENKFKTSRYLSVVERLNLAIQLQLSETQVKIWFQNRRTKWKKHNPGQDANTPQTPPSSDETQIQPILPANP 87
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A1I8IRK3 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 134.806 bits (338), Expect = 3.000e-34 Identity = 65/79 (82.28%), Postives = 68/79 (86.08%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELS 555 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA L LTE QVKIWFQNRRTKWKKQNPG DV+ Y SS +T LS Sbjct: 69 KQRRARTAFTYEQLVALENKFKSTRYLSVCERLNLAMRLSLTETQVKIWFQNRRTKWKKQNPGLDVNAY--SSAQTLLS 145
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A1I8I6F8 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 134.806 bits (338), Expect = 3.032e-34 Identity = 65/79 (82.28%), Postives = 68/79 (86.08%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELS 555 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA L LTE QVKIWFQNRRTKWKKQNPG DV+ Y SS +T LS Sbjct: 69 KQRRARTAFTYEQLVALENKFKSTRYLSVCERLNLAMRLSLTETQVKIWFQNRRTKWKKQNPGLDVNAY--SSAQTLLS 145
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A1B0DAB2 (Homeobox domain-containing protein OS=Phlebotomus papatasi OX=29031 PE=4 SV=1) HSP 1 Score: 129.798 bits (325), Expect = 6.618e-34 Identity = 67/87 (77.01%), Postives = 71/87 (81.61%), Query Frame = 1 Query: 259 SWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVH 519 S NS S +QSN + K RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV+ Sbjct: 25 SRNSKGNSDGKSQSNGT---KPRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDVN 108
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A182PQZ1 (Homeobox domain-containing protein OS=Anopheles epiroticus OX=199890 PE=4 SV=1) HSP 1 Score: 130.568 bits (327), Expect = 1.150e-33 Identity = 73/111 (65.77%), Postives = 78/111 (70.27%), Query Frame = 1 Query: 184 DDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 D GS ED H SE + G +N +Q N+S K RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 4 DTMGSDMED--HASETDSKKDG-----TNNRGGDGKSQGNSS---KPRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDV 104
BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A182SFV6 (Homeobox domain-containing protein OS=Anopheles maculatus OX=74869 PE=4 SV=1) HSP 1 Score: 129.798 bits (325), Expect = 2.159e-33 Identity = 73/111 (65.77%), Postives = 78/111 (70.27%), Query Frame = 1 Query: 184 DDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 D GS +D H SE + G SN++S NS K RRARTAFTYEQLVSLENKFK+TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 4 DTMGSDMDD--HASETDSKKDG------SNNRSGDGKSQGNSSK--PRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDV 104
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: nkx1.2lb (NK1 transcription factor related 2-like,b [Source:ZFIN;Acc:ZDB-GENE-040615-2]) HSP 1 Score: 128.642 bits (322), Expect = 2.509e-34 Identity = 59/66 (89.39%), Postives = 61/66 (92.42%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 191 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT 256
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: nkx1.2la (NK1 transcription factor-related protein 2-like [Source:NCBI gene;Acc:103033039]) HSP 1 Score: 125.946 bits (315), Expect = 5.309e-34 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 + RRARTAFTYEQLV+LENKF+STRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 135 RPRRARTAFTYEQLVALENKFRSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 199
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: pnx (homeobox protein CHOX-7-like [Source:NCBI gene;Acc:107197447]) HSP 1 Score: 89.3521 bits (220), Expect = 5.571e-21 Identity = 48/89 (53.93%), Postives = 59/89 (66.29%), Query Frame = 1 Query: 247 GEEYSWNSNSKSC--SPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 GEE +++S S SP + K+RR RTAFT EQL LE F+S+ YLSV ER +A +L+L+E QVKIWFQNRRTKWKK G Sbjct: 50 GEESPADTDSLSAPDSPAPDSPVPTRKARRIRTAFTLEQLRVLERSFQSSHYLSVLERHVIASALRLSETQVKIWFQNRRTKWKKSREG 138
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: gbx1 (gastrulation brain homeobox 1 [Source:NCBI gene;Acc:103022497]) HSP 1 Score: 88.1965 bits (217), Expect = 1.175e-19 Identity = 40/81 (49.38%), Postives = 56/81 (69.14%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELSLP 561 KSRR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G+ ++ ++ +P Sbjct: 219 KSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNAGGRSGEPARNPKIVVP 299
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: gbx2 (gastrulation brain homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-020509-2]) HSP 1 Score: 87.0409 bits (214), Expect = 3.615e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 234 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 296
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153]) HSP 1 Score: 74.7146 bits (182), Expect = 3.465e-17 Identity = 35/61 (57.38%), Postives = 45/61 (73.77%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQN 501 K R+ARTAF+ QL LE F+ +YLSV +R+ LA SL L++ QVK W+QNRRTKWK+Q Sbjct: 4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKWKRQT 64
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153]) HSP 1 Score: 75.0998 bits (183), Expect = 5.161e-17 Identity = 35/61 (57.38%), Postives = 45/61 (73.77%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQN 501 K R+ARTAF+ QL LE F+ +YLSV +R+ LA SL L++ QVK W+QNRRTKWK+Q Sbjct: 4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKWKRQT 64
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: MSX1 (msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]) HSP 1 Score: 73.9442 bits (180), Expect = 1.533e-16 Identity = 36/78 (46.15%), Postives = 52/78 (66.67%), Query Frame = 1 Query: 322 SRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELS 555 +R+ RT FT QL++LE+KF+ +YLS+ ER + SL LTE QVKIWFQNRR K K+ +++ + ++K LS Sbjct: 14 TRKPRTPFTTSQLLALEHKFRQKQYLSIAERAEFSTSLSLTETQVKIWFQNRRAKAKRLQ-EAELERLKMAAKPPALS 90
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 72.0182 bits (175), Expect = 2.580e-16 Identity = 36/63 (57.14%), Postives = 43/63 (68.25%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K RR RTAF+ +QL+ LE F RYLS +R +A +L LTE QVKIWFQNRR KWK+ G Sbjct: 2 KCRRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKWKRGKGG 64
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: hoxd4a (homeobox D4a [Source:NCBI gene;Acc:30329]) HSP 1 Score: 70.8626 bits (172), Expect = 4.821e-16 Identity = 33/58 (56.90%), Postives = 45/58 (77.59%), Query Frame = 1 Query: 322 SRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKK 495 S+R+RTA+T +Q++ LE +F RYL+ R+ +AHSL L+E Q+KIWFQNRR KWKK Sbjct: 2 SKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKK 59
BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264]) HSP 1 Score: 45.8246 bits (107), Expect = 4.630e-6 Identity = 29/86 (33.72%), Postives = 45/86 (52.33%), Query Frame = 1 Query: 253 EYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGS 510 ++ ++N S S N S++ R RT E L L+ KF+ S+ ER ++ + + E V+IWFQNRR K +K+ GS Sbjct: 57 DHDQHTNDMSASSNASDSG---PQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGS 139
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: NK-1 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI80]) HSP 1 Score: 129.798 bits (325), Expect = 9.437e-36 Identity = 64/86 (74.42%), Postives = 69/86 (80.23%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELSLPQRPSS 576 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV + T ++P P+S Sbjct: 156 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLGLTETQVKIWFQNRRTKWKKQNPGMDV------TAPTRPNIPHGPAS 235
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO38891 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBL6]) HSP 1 Score: 78.9518 bits (193), Expect = 6.400e-19 Identity = 39/59 (66.10%), Postives = 45/59 (76.27%), Query Frame = 1 Query: 322 SRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 SRR RTAFT QL SLE KF+ +YL++ ER +LA S+ LT QVK WFQNRRTKWKKQ Sbjct: 1 SRRRRTAFTSSQLKSLEEKFQEKKYLTISERNSLAKSMHLTNTQVKTWFQNRRTKWKKQ 59
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO32495 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUX2]) HSP 1 Score: 78.1814 bits (191), Expect = 9.363e-19 Identity = 36/58 (62.07%), Postives = 47/58 (81.03%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 +R RTAFT EQ+ LE +F+ ++YLSV R+ LA+SL LTE Q+KIWFQNRRTKWK++ Sbjct: 2 KRPRTAFTNEQIKDLEAEFQKSKYLSVSRRMELANSLSLTETQIKIWFQNRRTKWKRK 59
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO43402 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYQ0]) HSP 1 Score: 77.7962 bits (190), Expect = 1.717e-18 Identity = 38/60 (63.33%), Postives = 45/60 (75.00%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 KSRR RTAFT QL LE KF+ +YL++ ER LA S+ L++ QVK WFQNRRTKWKKQ Sbjct: 10 KSRRKRTAFTSSQLKYLEEKFQEKKYLTISERNELAKSMYLSDTQVKTWFQNRRTKWKKQ 69
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO47164 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMV1]) HSP 1 Score: 72.4034 bits (176), Expect = 1.475e-16 Identity = 38/61 (62.30%), Postives = 47/61 (77.05%), Query Frame = 1 Query: 325 RRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 RR RTAFT QL LE+KFK ++YL++ ER +A SLQLT Q+K WFQNRRTKWK++N G Sbjct: 1 RRKRTAFTSFQLKCLEDKFKFSKYLTIAERDMMARSLQLTNRQIKTWFQNRRTKWKRENVG 61
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: nkx1.2lb (NK1 homeobox 1 [Source:NCBI gene;Acc:101166641]) HSP 1 Score: 129.413 bits (324), Expect = 3.908e-34 Identity = 59/66 (89.39%), Postives = 61/66 (92.42%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 252 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT 317
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: nkx1.2lb (NK1 homeobox 1 [Source:NCBI gene;Acc:101166641]) HSP 1 Score: 128.642 bits (322), Expect = 6.275e-34 Identity = 59/66 (89.39%), Postives = 61/66 (92.42%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 K RRARTAFTYEQLV+LENKFKSTRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 235 KPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT 300
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: nkx1.2la (NK1 homeobox 2 [Source:NCBI gene;Acc:101168069]) HSP 1 Score: 124.79 bits (312), Expect = 1.381e-33 Identity = 57/65 (87.69%), Postives = 61/65 (93.85%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSD 513 K RRARTAFTYEQLV+LENKF++TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG+D Sbjct: 129 KPRRARTAFTYEQLVALENKFRTTRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGAD 193
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: gbx1 (gastrulation brain homeobox 1 [Source:NCBI gene;Acc:101173976]) HSP 1 Score: 88.1965 bits (217), Expect = 1.450e-19 Identity = 39/63 (61.90%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 KSRR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 219 KSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAG 281
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: gbx2 (gastrulation brain homeobox 2 [Source:NCBI gene;Acc:101166199]) HSP 1 Score: 87.0409 bits (214), Expect = 4.707e-19 Identity = 38/63 (60.32%), Postives = 49/63 (77.78%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPG 507 K+RR RTAFT EQL+ LE +F +YLS+ ER +AH+L+L+E+QVKIWFQNRR KWK+ G Sbjct: 248 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAG 310
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000041571.1 (SMESG000041571.1) HSP 1 Score: 501.901 bits (1291), Expect = 0.000e+0 Identity = 244/244 (100.00%), Postives = 244/244 (100.00%), Query Frame = 1 Query: 136 MPNHPFQIDNLLSKTLDDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELSLPQRPSSKNEKNCSFGFVNERNNKSKPRTNSTTSNPASLHESSPTPLHQGIYQYPFYKNTYDSTHWLNSATTNPYNWVSSGISNFQNCPGVSYSDLLLNYSNIM 867 MPNHPFQIDNLLSKTLDDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELSLPQRPSSKNEKNCSFGFVNERNNKSKPRTNSTTSNPASLHESSPTPLHQGIYQYPFYKNTYDSTHWLNSATTNPYNWVSSGISNFQNCPGVSYSDLLLNYSNIM Sbjct: 1 MPNHPFQIDNLLSKTLDDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVHHYQNSSKKTELSLPQRPSSKNEKNCSFGFVNERNNKSKPRTNSTTSNPASLHESSPTPLHQGIYQYPFYKNTYDSTHWLNSATTNPYNWVSSGISNFQNCPGVSYSDLLLNYSNIM 244
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000051002.1 (SMESG000051002.1) HSP 1 Score: 124.79 bits (312), Expect = 6.098e-33 Identity = 57/67 (85.07%), Postives = 61/67 (91.04%), Query Frame = 1 Query: 316 LKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDV 516 +K RRART+FTY+QLV+LENKFK TRYLSVCERLNLA SL LTE QVKIWFQNRRTKWKKQNPG DV Sbjct: 161 MKPRRARTSFTYDQLVALENKFKITRYLSVCERLNLAFSLNLTETQVKIWFQNRRTKWKKQNPGLDV 227
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000077917.1 (SMESG000077917.1) HSP 1 Score: 113.62 bits (283), Expect = 1.282e-29 Identity = 69/119 (57.98%), Postives = 81/119 (68.07%), Query Frame = 1 Query: 181 LDDEGSAFEDSYHYSELVKCRVGEEYSWNS------NSKSCSPNQSNNSLKLKSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQNPGSDVH 519 +D E + FE S ++ C ++Y ++ N + S N L K RRARTAFTYEQLV+LENKFK TRYLSVCERLNLA +L LTE QVKIWFQNRRTKWKKQNPG DV+ Sbjct: 45 IDSEKNFFEFLNDKSNILNCTNLQKYKYSDVHGPGVNKNIATKEGSMNFLNNKPRRARTAFTYEQLVALENKFKVTRYLSVCERLNLALTLNLTETQVKIWFQNRRTKWKKQNPGQDVN 163
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000019482.1 (SMESG000019482.1) HSP 1 Score: 82.8037 bits (203), Expect = 1.497e-17 Identity = 55/126 (43.65%), Postives = 71/126 (56.35%), Query Frame = 1 Query: 139 PNHPFQIDN---LLSKTLDDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCSPNQSNNSLKLKSRR---ARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ 498 P + F ID+ + K LDD F + +E+ S++ S+S N S N+ KL RR RT F+ Q+ LE+ F RYLS ER +LAH+LQLTE QVKIWFQNRR KWK+Q Sbjct: 153 PENRFLIDSSSQVDQKDLDDICRDFTEDVIDNEV--------DSFSQASESEDGNLSANNTKLSLRRKKKTRTVFSRNQVFQLESTFDLKRYLSSSERASLAHALQLTETQVKIWFQNRRNKWKRQ 270
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000022963.1 (SMESG000022963.1) HSP 1 Score: 77.411 bits (189), Expect = 1.221e-16 Identity = 38/67 (56.72%), Postives = 50/67 (74.63%), Query Frame = 1 Query: 319 KSRRARTAFTYEQLVSLENKFKSTRYLSVCERLNLAHSLQLTEIQVKIWFQNRRTKWKKQ-NPGSDV 516 + R+ARTAFT +QL LE F +YLSV +RL LA+ L+LT+ QVK W+QNRRTKWK+Q + G D+ Sbjct: 65 RPRKARTAFTEKQLCELEKSFDKHKYLSVQDRLELANYLELTDTQVKTWYQNRRTKWKRQTSTGVDL 131 The following BLAST results are available for this feature:
BLAST of Homeobox domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Homeobox domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30005805 ID=SMED30005805|Name=Homeobox domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=939bpback to top protein sequence of SMED30005805-orf-1 >SMED30005805-orf-1 ID=SMED30005805-orf-1|Name=SMED30005805-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=245bp MPNHPFQIDNLLSKTLDDEGSAFEDSYHYSELVKCRVGEEYSWNSNSKSCback to top Aliases
The feature 'Homeobox domain-containing protein' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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