hesl-2 protein

Overview
Namehesl-2 protein (AGZ94926.1)
Smed IDSMED30005790
Length (bp)717
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of hesl-2 protein (SMED30005790) t-SNE clustered cells

Violin plots show distribution of expression levels for hesl-2 protein (SMED30005790) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of hesl-2 protein (SMED30005790) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for hesl-2 protein (SMED30005790) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30005790

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30005790h1SMcG0016219 SmedASXL_007074SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
X1 cellSMED30005790h1SMcG0016219 SmedASXL_007074SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
progenitor cellSMED30005790h1SMcG0016219 KF487111smed_ncbi_20240424PMID:24173799
Cowles et al., 2013		whole organism asexual adult colorimetric in situ hybridization evidence
stem cellSMED30005790h1SMcG0016219 KF487111smed_ncbi_20240424PMID:24173799
Cowles et al., 2013		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30005790h1SMcG0016219 KF487111smed_ncbi_20240424PMID:24173799
Cowles et al., 2013		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of hesl-2 protein vs. Ensembl Human
Match: HES5 (hes family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:19764])

HSP 1 Score: 70.4774 bits (171), Expect = 1.374e-14
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 119
[Close]
BLAST of hesl-2 protein vs. Ensembl Human
Match: HES5 (hes family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:19764])

HSP 1 Score: 70.4774 bits (171), Expect = 1.374e-14
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 119
[Close]
BLAST of hesl-2 protein vs. Ensembl Human
Match: HES1 (hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192])

HSP 1 Score: 62.003 bits (149), Expect = 7.695e-11
Identity = 41/98 (41.84%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK +        TA    L+ +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLSQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAA---LSTDP-SVLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Human
Match: HES4 (hes family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24149])

HSP 1 Score: 59.6918 bits (143), Expect = 3.463e-10
Identity = 41/98 (41.84%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+  +++ KES    KLEKADILE  V+ +        TA    L+ +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPVMEKRRRARINESLAQLKTLI-LDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAA---LSADP-AVLGKYRAGFHECLAEVNRFLAGCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Human
Match: HES4 (hes family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24149])

HSP 1 Score: 59.6918 bits (143), Expect = 4.534e-10
Identity = 41/98 (41.84%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+  +++ KES    KLEKADILE  V+ +        TA    L+ +P  +L  +  G+  C  E+ RFL    G
Sbjct:   64 SKPVMEKRRRARINESLAQLKTLI-LDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAA---LSADP-AVLGKYRAGFHECLAEVNRFLAGCEG 156
[Close]
BLAST of hesl-2 protein vs. Ensembl Celegans
Match: lin-22 (Lin-22 [Source:UniProtKB/TrEMBL;Acc:G5EF76])

HSP 1 Score: 48.9062 bits (115), Expect = 3.806e-7
Identity = 28/56 (50.00%), Postives = 37/56 (66.07%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLL----EENSVTKESFVKLEKADILERAVKFMTH 313
            NKPLME++RR RIN +L QLK +L     +NS+      K EKADILE AV+++  
Sbjct:   25 NKPLMEKKRRARINKSLSQLKQILIQDEHKNSI---QHSKWEKADILEMAVEYLQQ 77
[Close]
BLAST of hesl-2 protein vs. Ensembl Fly
Match: dpn (gene:FBgn0010109 transcript:FBtr0088803)

HSP 1 Score: 68.1662 bits (165), Expect = 5.311e-13
Identity = 38/94 (40.43%), Postives = 56/94 (59.57%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNL--NKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            NKP+ME+RRR RIN  L++LK+L LE          KLEKADILE  VK +     ++ N+    +P  ++  F TG+V C +E+ R++  + G
Sbjct:   44 NKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPS-VVQKFKTGFVECAEEVNRYVSQMDG 136
[Close]
BLAST of hesl-2 protein vs. Ensembl Fly
Match: E(spl)m7-HLH (gene:FBgn0002633 transcript:FBtr0084960)

HSP 1 Score: 65.0846 bits (157), Expect = 9.411e-13
Identity = 38/88 (43.18%), Postives = 50/88 (56.82%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNL 424
            KPL+ER+RR RIN  LD+LK L+ E  V +    K EKADILE  V+ +      KK++  NP     SF  GY+    E+ R L +L
Sbjct:   18 KPLLERKRRARINKCLDELKDLMAE-CVAQTGDAKFEKADILEVTVQHLRKLKESKKHVPANPEQ---SFRAGYIRAANEVSRALASL 101
[Close]
BLAST of hesl-2 protein vs. Ensembl Fly
Match: E(spl)mbeta-HLH (gene:FBgn0002733 transcript:FBtr0084982)

HSP 1 Score: 63.929 bits (154), Expect = 3.244e-12
Identity = 53/183 (28.96%), Postives = 85/183 (46.45%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEEN-SVTKESFVKLEKADILERAVKFMTHTTAEKK----------NLNKNPR-HLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNV--------KVNEKNINNLKPGEPLSIGSSQLD-LKFLNRRTYNSVWRPW 646
            KP++ER+RR RIN  LD+LK ++ E  +   E   +LEKADILE  V+ M    A+K+          + + +P+  + +SF  GYV    E+ + L  + G S   + L    +      +NY  +Q +VP++         V ++ +    P E  S+ S            T   +WRPW
Sbjct:   18 KPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVS---VDLGTQLMSHLGHRLNY--LQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW 195
[Close]
BLAST of hesl-2 protein vs. Ensembl Fly
Match: Hesr (gene:FBgn0030899 transcript:FBtr0074590)

HSP 1 Score: 62.003 bits (149), Expect = 6.514e-12
Identity = 40/105 (38.10%), Postives = 60/105 (57.14%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENS-VTKESFVKLEKADILERAVKFM--------THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLR-NLYGPSNPF 445
            KP+MER+RR RIN  LD +K LL+E S +  E+  K++  D+LE AV  +        T TTA    + ++P   +D + +G+  C  E+ +FL+ N Y PS  F
Sbjct:   26 KPMMERKRRSRINRCLDFIKDLLQEVSHLDGETMAKMDMGDVLELAVHHLSKKNCPVATPTTAPTSGVYQSP---IDCYWSGFRECVLEVSQFLQHNGYQPSFEF 127
[Close]
BLAST of hesl-2 protein vs. Ensembl Fly
Match: Sidpn (gene:FBgn0032741 transcript:FBtr0081141)

HSP 1 Score: 63.5438 bits (153), Expect = 2.325e-11
Identity = 41/114 (35.96%), Postives = 57/114 (50.00%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--------FVKLEKADILERAVK-FMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLE 472
            NKPLME+RRR RIN +L  LK L+ E++ T+ +          KLEKADILE  V+ F  H   +   +NK        +  GY  C +E+ R+L     P  P +  +    E
Sbjct:   54 NKPLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLDDPTVNK--------YRAGYTDCAREVARYLAT---PEPPPMGTMPTLAE 156
[Close]
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Match: her3 (hairy-related 3 [Source:ZFIN;Acc:ZDB-GENE-980526-204])

HSP 1 Score: 64.3142 bits (155), Expect = 6.398e-12
Identity = 39/89 (43.82%), Postives = 52/89 (58.43%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDS--FNTGYVACEKEIMRFLR 418
            +KPLME++RR RIN  L+QLK+LLE          KLEKADILE  VK + H    K+ L+K      DS  ++ GY +C   +  +LR
Sbjct:   44 SKPLMEKKRRARINKCLNQLKSLLESACSNNIRKRKLEKADILELTVKHLRHLQNTKRGLSK----ACDSAEYHAGYRSCLNTVSHYLR 128
[Close]
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Match: her6 (hairy-related 6 [Source:ZFIN;Acc:ZDB-GENE-980526-144])

HSP 1 Score: 64.3142 bits (155), Expect = 6.620e-12
Identity = 40/95 (42.11%), Postives = 57/95 (60.00%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMTHTTAEK--KNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK + +    +    LN +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLGQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNMQRAQMTAALNTDPT-VLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Match: her12 (hairy-related 12 [Source:ZFIN;Acc:ZDB-GENE-040824-5])

HSP 1 Score: 62.3882 bits (150), Expect = 7.186e-12
Identity = 48/163 (29.45%), Postives = 73/163 (44.79%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNR-RTYNSVWRPW 646
            KP++E+ RR RIN  +DQLK+LLE+   + +   KLEKADILE  V F+     +++ + +        FN GY  C +E + FL +L+                     N   +Q +    K N         G   +   S+L+   L    +  +VWRPW
Sbjct:   26 KPIVEKMRRDRINTCIDQLKSLLEKEFHSHDPSTKLEKADILEMTVSFLKQQIKQQQQIPQR------DFNEGYSHCWRESVHFL-SLHS--------------------NAGELQHLHSGPKTNSTM------GSTPATACSKLNTAALQHPDSVRAVWRPW 155
[Close]
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Match: her6 (hairy-related 6 [Source:ZFIN;Acc:ZDB-GENE-980526-144])

HSP 1 Score: 64.3142 bits (155), Expect = 9.565e-12
Identity = 40/95 (42.11%), Postives = 57/95 (60.00%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMTHTTAEK--KNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK + +    +    LN +P  +L  +  G+  C  E+ RFL    G
Sbjct:   95 SKPIMEKRRRARINESLGQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNMQRAQMTAALNTDPT-VLGKYRAGFSECMNEVTRFLSTCEG 187
[Close]
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Match: her8.2 (hairy-related 8.2 [Source:ZFIN;Acc:ZDB-GENE-060815-4])

HSP 1 Score: 59.6918 bits (143), Expect = 1.764e-10
Identity = 36/90 (40.00%), Postives = 53/90 (58.89%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKN---LNKNPRHLLDSFNTGYVACEKEIMRFLRN 421
            KPL+ER+RR+RIN  LDQL+  +   +V K    KLEKADILE  VK + +  + + +   LN   R     ++TGY+ C +E+   L +
Sbjct:   39 KPLIERKRRERINLCLDQLRETVV--AVFKPDQSKLEKADILEMTVKHLQNIQSSRVSDPVLNTGAR---QRYSTGYIQCMQEVHNLLHS 123
[Close]
BLAST of hesl-2 protein vs. Ensembl Xenopus
Match: dennd5b (DENN/MADD domain containing 5B [Source:Xenbase;Acc:XB-GENE-1009600])

HSP 1 Score: 70.0922 bits (170), Expect = 2.020e-14
Identity = 38/89 (42.70%), Postives = 55/89 (61.80%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKN---PRHLLDSFNTGYVACEKEIMRFLR 418
            KP++E+ RR RIN +++QL+ LLE N  T     KLEKADILE AV ++     +K  +N++   P ++ DS+  GY  C KE + FL 
Sbjct:   26 KPVIEKMRRDRINHSIEQLRILLERNFQTHHPHSKLEKADILEMAVSYL--QQQKKHQMNRSHLLPENVQDSYYQGYYMCLKETVGFLH 112
[Close]
BLAST of hesl-2 protein vs. Ensembl Xenopus
Match: ENSXETT00000026370.1 (transcription factor HES-5 [Source:NCBI gene;Acc:101733898])

HSP 1 Score: 67.0106 bits (162), Expect = 4.733e-13
Identity = 36/85 (42.35%), Postives = 54/85 (63.53%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            KP++E+ RR RIN +++QLK LLE+    +E  VKLEKADILE AV ++    ++  NL K    L   +  G+ +C +E ++FL
Sbjct:   56 KPIVEKMRRDRINNSIEQLKALLEKEFHKQEPNVKLEKADILEMAVSYLQQQKSQSPNLAK----LEQDYKQGFSSCLREAVQFL 136
[Close]
BLAST of hesl-2 protein vs. Ensembl Xenopus
Match: ENSXETT00000038440.1 (transcription factor HES-5 [Source:NCBI gene;Acc:101733898])

HSP 1 Score: 63.1586 bits (152), Expect = 1.881e-12
Identity = 34/85 (40.00%), Postives = 52/85 (61.18%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            KP++E+ RR RIN +++QLK LLE+    +E  VKLEKADILE AV ++       +  + N   L   +  G+ +C +E ++FL
Sbjct:   23 KPIVEKMRRDRINNSIEQLKALLEKEFHKQEPNVKLEKADILEMAVSYLQQQKNSVRGQSPNLAKLEQDYKQGFSSCLREAVQFL 107
[Close]
BLAST of hesl-2 protein vs. Ensembl Xenopus
Match: ccdc63 (coiled-coil domain containing 63 [Source:Xenbase;Acc:XB-GENE-5873552])

HSP 1 Score: 62.003 bits (149), Expect = 6.249e-11
Identity = 41/98 (41.84%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK +        TA    L+ +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLGQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTAA---LSTDPS-VLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Xenopus
Match: drc3 (dynein regulatory complex subunit 3 [Source:Xenbase;Acc:XB-GENE-1003585])

HSP 1 Score: 60.4622 bits (145), Expect = 1.138e-10
Identity = 35/86 (40.70%), Postives = 51/86 (59.30%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            +KPLME++RR RIN +L+QLK LLE+N        KLEKADILE  VK++      + ++  NP +    +  G+  C   + +FL
Sbjct:   20 SKPLMEKKRRARINVSLEQLKGLLEKNYSQNIRKRKLEKADILELTVKYL---KTLQNSIQGNPLYRSTEYQAGFRNCLNGVNQFL 102
[Close]
BLAST of hesl-2 protein vs. Ensembl Mouse
Match: Hes5 (hes family bHLH transcription factor 5 [Source:MGI Symbol;Acc:MGI:104876])

HSP 1 Score: 71.2478 bits (173), Expect = 5.140e-15
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 119
[Close]
BLAST of hesl-2 protein vs. Ensembl Mouse
Match: Hes1 (hes family bHLH transcription factor 1 [Source:MGI Symbol;Acc:MGI:104853])

HSP 1 Score: 61.6178 bits (148), Expect = 7.156e-11
Identity = 41/98 (41.84%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK +        TA    L+ +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLSQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAA---LSTDPS-VLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Mouse
Match: Hes3 (hes family bHLH transcription factor 3 [Source:MGI Symbol;Acc:MGI:104877])

HSP 1 Score: 60.077 bits (144), Expect = 1.023e-10
Identity = 52/181 (28.73%), Postives = 81/181 (44.75%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLE-TNKDSIN---YSFIQRIVPNVKVNEKNINNL-KPGEPLSIGSSQLD-------------LKFLNRRTYNSVWRPW 646
            +KPLME++RR RIN +L+QL++LLE +   +    KLEKADILE +VK+M       + L   P  +   + +G+    + + + LR   G S     L+    E +  DS N    S +   +P +    +       P  PL +    L+              +  + R    VWRPW
Sbjct:   22 SKPLMEKKRRARINVSLEQLRSLLERHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPSGV--DYPSGFQGGLRGVSQRLRPGEGDSGLRCPLLLQRREGSTTDSANPQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGLLESSTDVVAPHPASNCQAESTRPGFRVWRPW 200
[Close]
BLAST of hesl-2 protein vs. Ensembl Mouse
Match: Hes3 (hes family bHLH transcription factor 3 [Source:MGI Symbol;Acc:MGI:104877])

HSP 1 Score: 53.9138 bits (128), Expect = 1.463e-8
Identity = 49/177 (27.68%), Postives = 77/177 (43.50%), Query Frame = 2 
Query:  170 MERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLE-TNKDSIN---YSFIQRIVPNVKVNEKNINN-LKPGEPLSIGSSQLD-------------LKFLNRRTYNSVWRPW 646
            ME++RR RIN +L+QL++LLE +   +    KLEKADILE +VK+M       + L   P  +   + +G+    + + + LR   G S     L+    E +  DS N    S +   +P +    +       P  PL +    L+              +  + R    VWRPW
Sbjct:    1 MEKKRRARINVSLEQLRSLLERHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPSGV--DYPSGFQGGLRGVSQRLRPGEGDSGLRCPLLLQRREGSTTDSANPQATSVLNPCLPAIWAPSRAAGGSHSPQSPLPLPGGLLESSTDVVAPHPASNCQAESTRPGFRVWRPW 175
[Close]
BLAST of hesl-2 protein vs. Ensembl Mouse
Match: Hes2 (hes family bHLH transcription factor 2 [Source:MGI Symbol;Acc:MGI:1098624])

HSP 1 Score: 52.373 bits (124), Expect = 3.315e-8
Identity = 38/89 (42.70%), Postives = 49/89 (55.06%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTL---LEENSVTKESFVKLEKADILERAVKFMTHTTAE-KKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            KPL+E+RRR RIN +L QLK L   L     ++ S  KLEKADILE  V+F+    A    +    P   L+S+  GY AC   + R L
Sbjct:   18 KPLLEKRRRARINESLSQLKGLVLPLLGAETSRSS--KLEKADILEMTVRFLQEQPATLYSSAAPGP---LNSYLEGYRACLARLARVL 101
[Close]
BLAST of hesl-2 protein vs. UniProt/SwissProt
Match: sp|Q03062|HES5_RAT (Transcription factor HES-5 OS=Rattus norvegicus OX=10116 GN=Hes5 PE=2 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 1.966e-16
Identity = 51/163 (31.29%), Postives = 80/163 (49.08%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQR-IVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F             QR   P   V E       P +P    +        +R++   +WRPW
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKA--FAAAAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF-------------QRPPAPAAPVKETPTPGAAP-QPARSSTKAAASVSTSRQSACGLWRPW 166
[Close]
BLAST of hesl-2 protein vs. UniProt/SwissProt
Match: sp|P70120|HES5_MOUSE (Transcription factor HES-5 OS=Mus musculus OX=10090 GN=Hes5 PE=1 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 3.595e-14
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 119
[Close]
BLAST of hesl-2 protein vs. UniProt/SwissProt
Match: sp|Q5TA89|HES5_HUMAN (Transcription factor HES-5 OS=Homo sapiens OX=9606 GN=HES5 PE=2 SV=1)

HSP 1 Score: 70.4774 bits (171), Expect = 6.599e-14
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 119
[Close]
BLAST of hesl-2 protein vs. UniProt/SwissProt
Match: sp|Q26263|DPN_DROME (Protein deadpan OS=Drosophila melanogaster OX=7227 GN=dpn PE=1 SV=2)

HSP 1 Score: 68.1662 bits (165), Expect = 5.324e-12
Identity = 38/94 (40.43%), Postives = 56/94 (59.57%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNL--NKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            NKP+ME+RRR RIN  L++LK+L LE          KLEKADILE  VK +     ++ N+    +P  ++  F TG+V C +E+ R++  + G
Sbjct:   44 NKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPS-VVQKFKTGFVECAEEVNRYVSQMDG 136
[Close]
BLAST of hesl-2 protein vs. UniProt/SwissProt
Match: sp|P13097|ESM7_DROME (Enhancer of split m7 protein OS=Drosophila melanogaster OX=7227 GN=E(spl)m7-HLH PE=1 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 9.433e-12
Identity = 38/88 (43.18%), Postives = 50/88 (56.82%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNL 424
            KPL+ER+RR RIN  LD+LK L+ E  V +    K EKADILE  V+ +      KK++  NP     SF  GY+    E+ R L +L
Sbjct:   18 KPLLERKRRARINKCLDELKDLMAE-CVAQTGDAKFEKADILEVTVQHLRKLKESKKHVPANPEQ---SFRAGYIRAANEVSRALASL 101
[Close]
BLAST of hesl-2 protein vs. TrEMBL
Match: U5YR73 (Hesl-2 protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=hesl-2 PE=2 SV=1)

HSP 1 Score: 333.569 bits (854), Expect = 2.574e-114
Identity = 163/164 (99.39%), Postives = 164/164 (100.00%), Query Frame = 2 
Query:  182 RRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE 673
            RRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVP+VKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE
Sbjct:    1 RRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPSVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE 164
[Close]
BLAST of hesl-2 protein vs. TrEMBL
Match: A0A2Y9K887 (transcription factor HES-5 OS=Enhydra lutris kenyoni OX=391180 GN=LOC111154575 PE=4 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 6.020e-15
Identity = 51/164 (31.10%), Postives = 78/164 (47.56%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQR--IVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F             QR    P V   E       P   L+   +        R+    +WRPW
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAAAAAAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF-------------QRPPAAPTVPTKEPKATGTAPPPVLTPAKA---TAVAARQPTCGLWRPW 167
[Close]
BLAST of hesl-2 protein vs. TrEMBL
Match: E2QXY9 (Hes family bHLH transcription factor 5 OS=Canis lupus familiaris OX=9615 GN=HES5 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 3.621e-13
Identity = 51/164 (31.10%), Postives = 78/164 (47.56%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQR--IVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F             QR    P V   E       P   L+   +        R+    +WRPW
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHSASDTQMKLLYHF-------------QRPPAAPTVPTKEPKATGTVPPPVLTPAKA---TAVAARQPTCGLWRPW 165
[Close]
BLAST of hesl-2 protein vs. TrEMBL
Match: A0A3Q7SUW3 (transcription factor HES-5 OS=Vulpes vulpes OX=9627 GN=HES5 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 3.621e-13
Identity = 51/164 (31.10%), Postives = 78/164 (47.56%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQR--IVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F             QR    P V   E       P   L+   +        R+    +WRPW
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAA--AAGPKSLHQDYSEGYSWCLQEAVQFL-TLHSASDTQMKLLYHF-------------QRPPAAPTVPTKEPKATGTVPPPVLTPAKA---TAVAARQPTCGLWRPW 165
[Close]
BLAST of hesl-2 protein vs. TrEMBL
Match: A0A2Y9Q9X6 (transcription factor HES-5 isoform X2 OS=Delphinapterus leucas OX=9749 GN=HES5 PE=4 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 5.431e-13
Identity = 39/102 (38.24%), Postives = 62/102 (60.78%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNF 466
            KP++E+ RR RIN +++QLK LLE+     +   KLEKADILE AV ++ H+ A        P+ L   ++ GY  C +E ++FL  L+  S+  + L+++F
Sbjct:   21 KPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFAAAAAAGPKSLHQDYSEGYSWCLQEAVQFL-TLHAASDTQMKLLYHF 121
[Close]
BLAST of hesl-2 protein vs. Ensembl Cavefish
Match: her3 (transcription factor HES-1-like [Source:NCBI gene;Acc:103036755])

HSP 1 Score: 66.2402 bits (160), Expect = 4.670e-13
Identity = 39/89 (43.82%), Postives = 53/89 (59.55%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLE---ENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            +KP+ME++RR RIN  LDQLKTLLE    N+++K    KLEKADILE  VK + H    +K L  N       + +GY  C   + ++L
Sbjct:   18 SKPMMEKKRRARINTCLDQLKTLLENIYSNNISKR---KLEKADILELTVKHLKHLQKSEKGLAINSGG--SEYQSGYTTCLASVNQYL 101
[Close]
BLAST of hesl-2 protein vs. Ensembl Cavefish
Match: hes2.1 (transcription factor HES-2-like [Source:NCBI gene;Acc:103037387])

HSP 1 Score: 65.4698 bits (158), Expect = 6.632e-13
Identity = 54/177 (30.51%), Postives = 76/177 (42.94%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNS--------------VWRPW 646
            KPL+E+RRR RIN +L QLKTL L      K  + KLEKADILE  V+F+T   A  K      + + D++  GY AC + +   L                 L+         F+QR +P+     ++ +    G P +  + Q  L+ L      S              VWRPW
Sbjct:   24 KPLVEKRRRARINDSLHQLKTLILPLVGKEKCRYSKLEKADILEMTVRFLTDIPATPK------KDVADNYKEGYKACLQRVSALLPR-------------TGLDHEAGRRVTEFMQRAMPSSSPACQHCSGH--GAPATPQTPQQRLRSLQATVSRSESRASVVVPVSGAPVWRPW 179
[Close]
BLAST of hesl-2 protein vs. Ensembl Cavefish
Match: her6 (hes family bHLH transcription factor 1 [Source:NCBI gene;Acc:103029084])

HSP 1 Score: 64.3142 bits (155), Expect = 6.185e-12
Identity = 40/95 (42.11%), Postives = 57/95 (60.00%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMTHTTAEK--KNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK + +    +    LN +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLGQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNMQRAQMTAALNTDPT-VLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Cavefish
Match: ENSAMXT00000035814.1 (transcription factor HES-4-B-like [Source:NCBI gene;Acc:111194137])

HSP 1 Score: 62.7734 bits (151), Expect = 6.577e-12
Identity = 38/90 (42.22%), Postives = 52/90 (57.78%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKESF-VKLEKADILE---RAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            +KPL+ERRRR RIN  L +L++LL ++  T+     KLEKADILE   R ++ + HT +    +          F+ GY AC  EI RFL
Sbjct:   29 SKPLLERRRRARINACLGELRSLLLQSHATQGCHPSKLEKADILELTVRHLRSLQHTHSGGNGV----------FSVGYSACVCEIRRFL 108
[Close]
BLAST of hesl-2 protein vs. Ensembl Cavefish
Match: ENSAMXT00000032867.1 (pep primary_assembly:Astyanax_mexicanus-2.0:22:3794895:3796759:-1 gene:ENSAMXG00000036039.1 transcript:ENSAMXT00000032867.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 59.6918 bits (143), Expect = 1.417e-10
Identity = 48/163 (29.45%), Postives = 72/163 (44.17%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGE-PLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KP +E+ RR RIN  ++QLK +LE+    ++   KLEKADILE  V FM      K+ L       + + + GY  C +E + FL      +N  L +    L            QR  P   ++  +    KP + P+ I          +  +  +VWRPW
Sbjct:   64 KPAVEKMRRDRINNCIEQLKVMLEKEFHQQDPNTKLEKADILEMTVVFM------KQQLQSQISAPVKAHHDGYSQCWRETVNFLS-----ANSKLDVTLQHLN-----------QRQEPAKDLSHMSPAAFKPSQGPVPIKQE------TSSSSSRAVWRPW 198
[Close]
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Match: her9 (hairy-related 9 [Source:ZFIN;Acc:ZDB-GENE-011213-1])

HSP 1 Score: 58.5362 bits (140), Expect = 2.196e-11
Identity = 40/95 (42.11%), Postives = 52/95 (54.74%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMT--HTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
             KP+ME+RRR RIN +L+QLK L+ E ++ K+S    KLEKADILE  VK +   H       L      +L  +  GY  C  E+ RFL    G
Sbjct:   20 TKPIMEKRRRARINDSLNQLKALILE-TLRKDSSRHSKLEKADILELTVKHLRSLHRLHISAALCAADPGVLGRYRAGYSECVNEVTRFLSTSEG 113
[Close]
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Match: her9 (hairy-related 9 [Source:ZFIN;Acc:ZDB-GENE-011213-1])

HSP 1 Score: 58.9214 bits (141), Expect = 2.625e-11
Identity = 40/95 (42.11%), Postives = 52/95 (54.74%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMT--HTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
             KP+ME+RRR RIN +L+QLK L+ E ++ K+S    KLEKADILE  VK +   H       L      +L  +  GY  C  E+ RFL    G
Sbjct:   44 TKPIMEKRRRARINDSLNQLKALILE-TLRKDSSRHSKLEKADILELTVKHLRSLHRLHISAALCAADPGVLGRYRAGYSECVNEVTRFLSTSEG 137
[Close]
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004472.1 (pep scaffold:Pmarinus_7.0:GL476447:18322:19433:-1 gene:ENSPMAG00000004072.1 transcript:ENSPMAT00000004472.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 42.743 bits (99), Expect = 2.876e-6
Identity = 23/50 (46.00%), Postives = 36/50 (72.00%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKE-SFVKLEKADILERAVKFM 307
            KPL+E++RR RIN  L+ LK+++ ++S  +  S  KLEKADILE  + ++
Sbjct:   20 KPLVEKQRRDRINNLLEHLKSIILDSSQHEHASTSKLEKADILELTINYL 69
[Close]
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Match: bhlhe41 (basic helix-loop-helix family, member e41 [Source:ZFIN;Acc:ZDB-GENE-050419-146])

HSP 1 Score: 45.8246 bits (107), Expect = 3.128e-6
Identity = 33/96 (34.38%), Postives = 53/96 (55.21%), Query Frame = 2 
Query:  167 LMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILE---RAVKFMTHTTAEKKN----LNKNPRHLLD------SFNTGYVACEKEIMRFL 415
            L+E++RR RIN  + QLK LL E+ +   +   LEKA +LE   + VK +T  T +++     L K  +  +D      +F  GY AC +E++ +L
Sbjct:   53 LIEKKRRDRINECIAQLKDLLPEH-LKLSTLGHLEKAVVLELTLKHVKTLTSLTQQQQERLNVLQKGEQPEVDDQTGLQAFRLGYHACAREVLAYL 147
[Close]
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004474.1 (pep scaffold:Pmarinus_7.0:GL476447:34263:35715:1 gene:ENSPMAG00000004077.1 transcript:ENSPMAT00000004474.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 41.9726 bits (97), Expect = 5.650e-6
Identity = 23/50 (46.00%), Postives = 36/50 (72.00%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKE-SFVKLEKADILERAVKFM 307
            KPL+E++RR RIN  L+ LK+++ ++S  +  S  KLEKADILE  + ++
Sbjct:   20 KPLVEKQRRDRINNLLEHLKSIVLDSSQHEHASTSKLEKADILELTINYL 69
[Close]
BLAST of hesl-2 protein vs. Ensembl Nematostella
Match: HES4 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYX6])

HSP 1 Score: 58.151 bits (139), Expect = 2.896e-11
Identity = 36/86 (41.86%), Postives = 51/86 (59.30%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFL 415
            KP ME+ RR RIN +L++LK+L LE        + K+EKADILE  VK++  +  EK++   +P  L   +  GY  C  E+ RFL
Sbjct:    4 KPQMEKLRRARINDSLNELKSLVLEAMKKDASRYSKMEKADILEMTVKYL-RSAPEKQSKISDPTSLA-KYRAGYNECAAEVTRFL 87
[Close]
BLAST of hesl-2 protein vs. Ensembl Nematostella
Match: EDO45031 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU73])

HSP 1 Score: 56.9954 bits (136), Expect = 8.305e-10
Identity = 33/88 (37.50%), Postives = 50/88 (56.82%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFM--THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRF 412
            +KP+ME+RRR RIN +L++LK L LE        + KLEKADILE  VK++    TT +   +  +    +  +  G+  C  E+ R+
Sbjct:   21 SKPMMEKRRRARINQSLNELKILILEAMKKDTSCYSKLEKADILEMTVKYLRAMKTTQQLTGIVPSDPSSVAQYRAGFNECALEVTRY 108
[Close]
BLAST of hesl-2 protein vs. Ensembl Nematostella
Match: HL1 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMA9])

HSP 1 Score: 47.3654 bits (111), Expect = 8.831e-8
Identity = 27/51 (52.94%), Postives = 36/51 (70.59%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFM 307
            +KP+ME+RRR+RIN +L++LK L LE        + KLEKADILE  VK +
Sbjct:    3 SKPVMEKRRRERINRSLEELKRLVLEAQHRDCSRYTKLEKADILEMTVKHL 53
[Close]
BLAST of hesl-2 protein vs. Ensembl Nematostella
Match: EDO43262 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYX2])

HSP 1 Score: 48.521 bits (114), Expect = 5.809e-7
Identity = 34/107 (31.78%), Postives = 54/107 (50.47%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTLLEENSVTKE--SFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLET 475
            KPLME+ RR RIN +L+++K L+ E S+ K+   + K+EKADILE  VKF+      +++   N       +  GY     E+M  +     P+       +  L +
Sbjct:   28 KPLMEKLRRDRINNSLNEMKLLVLE-SLNKDVSRYSKMEKADILEMTVKFLKE--VNRQDSATNGAQSWSDYKAGYNRRGVEVMPNISTTNTPTGDLTGKFYTHLTS 131
[Close]
BLAST of hesl-2 protein vs. Ensembl Nematostella
Match: HES2 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYX7])

HSP 1 Score: 46.595 bits (109), Expect = 6.680e-7
Identity = 28/90 (31.11%), Postives = 53/90 (58.89%), Query Frame = 2 
Query:  182 RRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMTHTTAEKKNLNKN---PRHLLDSFNTGYVACEKEIMRFLRNLYGPS 436
            RR RIN +L++LK+L+ + S+ K++  + K+EKADILE +V+++     ++ + N       H +  +  G+  C +E+ + L  L  P+
Sbjct:    2 RRARINDSLNELKSLVLQ-SLNKDASRYSKMEKADILEMSVQYLKEIRKQENSYNGKLSFKAHSIAEYRAGFNYCAQEVTKNLTTLESPA 90
[Close]
BLAST of hesl-2 protein vs. Ensembl Medaka
Match: hes1 (hes family bHLH transcription factor 1 [Source:NCBI gene;Acc:100049484])

HSP 1 Score: 64.3142 bits (155), Expect = 5.860e-12
Identity = 42/98 (42.86%), Postives = 57/98 (58.16%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFM-----THTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLKTL+ + ++ K+S    KLEKADILE  VK +        TA    LN +P  +L  +  G+  C  E+ RFL    G
Sbjct:   38 SKPIMEKRRRARINESLGQLKTLILD-ALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAA---LNTDPS-VLGKYRAGFSECMNEVTRFLSTCEG 130
[Close]
BLAST of hesl-2 protein vs. Ensembl Medaka
Match: ENSORLT00000034583.1 (Her6.2 [Source:NCBI gene;Acc:100049440])

HSP 1 Score: 61.2326 bits (147), Expect = 5.976e-11
Identity = 39/98 (39.80%), Postives = 59/98 (60.20%), Query Frame = 2 
Query:  158 NKPLMERRRRQRINFALDQLKTLLEENSVTKES--FVKLEKADILERAVKFMT-----HTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            +KP+ME+RRR RIN +L QLK+L+  +++ K+S    KLEKADILE  VK +      H +A    ++ +P  +L  +  G+  C  E+ RFL +  G
Sbjct:   26 SKPIMEKRRRARINESLAQLKSLI-LDALKKDSCRHSKLEKADILEMTVKHLRNLQRLHVSAA---VHSDPS-VLSKYRAGFSECVGEVTRFLSSYEG 118
[Close]
BLAST of hesl-2 protein vs. Ensembl Medaka
Match: HES2 (transcription factor HES-2-like [Source:NCBI gene;Acc:101167286])

HSP 1 Score: 58.5362 bits (140), Expect = 1.809e-10
Identity = 54/176 (30.68%), Postives = 79/176 (44.89%), Query Frame = 2 
Query:  161 KPLMERRRRQRINFALDQLKTL-LEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNL------YGPSNPFLALVFNFLET-------NKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPW 646
            KPLME+RRR RIN +L+ LK L L      K  + KLEKADILE  V+F+           KNP H   S+  GY AC + +   L  +      +G  N F+      + T        + S  +  I + +  +K +  +     P    + G  ++    L+ +   SVWRPW
Sbjct:    2 KPLMEKRRRARINDSLNLLKNLILPLTGKDKTRYSKLEKADILEMTVRFLRDIPLVN---TKNPAH---SYGEGYKACLQRVSAVLPQIKLNQEAFGQVNDFVQKSMPAVVTPTCLNCCAQRSTTFPEIHQRLQRLKSSFNSRLESPPRNSAAAGPIRVQ---LSAQPLGSVWRPW 168
[Close]
BLAST of hesl-2 protein vs. Ensembl Medaka
Match: ENSORLT00000035222.1 (hairy/enhancer-of-split related with YRPW motif protein 2 [Source:NCBI gene;Acc:101169991])

HSP 1 Score: 60.077 bits (144), Expect = 2.120e-10
Identity = 35/88 (39.77%), Postives = 52/88 (59.09%), Query Frame = 2 
Query:  167 LMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            ++E+RRR RIN +L +L+ L+   S  K+   KLEKA+IL+  V  +    AEK NL + P   LD  + G+  C  E+ RFL ++ G
Sbjct:   46 IVEKRRRDRINSSLSELRRLVPTAS-EKQGSAKLEKAEILQMTVDHLKMLQAEKGNL-EGPALALDFLSLGFRECVTEVSRFLSSMEG 131
[Close]
BLAST of hesl-2 protein vs. Ensembl Medaka
Match: ENSORLT00000043193.1 (hairy/enhancer-of-split related with YRPW motif protein 2 [Source:NCBI gene;Acc:101169991])

HSP 1 Score: 60.077 bits (144), Expect = 2.467e-10
Identity = 35/88 (39.77%), Postives = 52/88 (59.09%), Query Frame = 2 
Query:  167 LMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYG 430
            ++E+RRR RIN +L +L+ L+   S  K+   KLEKA+IL+  V  +    AEK NL + P   LD  + G+  C  E+ RFL ++ G
Sbjct:   53 IVEKRRRDRINSSLSELRRLVPTAS-EKQGSAKLEKAEILQMTVDHLKMLQAEKGNL-EGPALALDFLSLGFRECVTEVSRFLSSMEG 138
[Close]
BLAST of hesl-2 protein vs. Planmine SMEST
Match: SMESG000068772.1 (SMESG000068772.1)

HSP 1 Score: 361.688 bits (927), Expect = 1.938e-128
Identity = 199/199 (100.00%), Postives = 199/199 (100.00%), Query Frame = 2 
Query:   77 MSSIPNRXXXXXXXXXXXXXXXXXXXXNKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE 673
            MSSIPNRISTKIKKQSQSKQFSTLKKSNKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE
Sbjct:    1 MSSIPNRISTKIKKQSQSKQFSTLKKSNKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVKFMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLALVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDLKFLNRRTYNSVWRPWEMSVDKLDE 199
The following BLAST results are available for this feature:
BLAST of hesl-2 protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HES51.374e-1438.24hes family bHLH transcription factor 5 [Source:HGN... [more]
HES51.374e-1438.24hes family bHLH transcription factor 5 [Source:HGN... [more]
HES17.695e-1141.84hes family bHLH transcription factor 1 [Source:HGN... [more]
HES43.463e-1041.84hes family bHLH transcription factor 4 [Source:HGN... [more]
HES44.534e-1041.84hes family bHLH transcription factor 4 [Source:HGN... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
lin-223.806e-750.00Lin-22 [Source:UniProtKB/TrEMBL;Acc:G5EF76][more]
back to top
BLAST of hesl-2 protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dpn5.311e-1340.43gene:FBgn0010109 transcript:FBtr0088803[more]
E(spl)m7-HLH9.411e-1343.18gene:FBgn0002633 transcript:FBtr0084960[more]
E(spl)mbeta-HLH3.244e-1228.96gene:FBgn0002733 transcript:FBtr0084982[more]
Hesr6.514e-1238.10gene:FBgn0030899 transcript:FBtr0074590[more]
Sidpn2.325e-1135.96gene:FBgn0032741 transcript:FBtr0081141[more]
back to top
BLAST of hesl-2 protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
her36.398e-1243.82hairy-related 3 [Source:ZFIN;Acc:ZDB-GENE-980526-2... [more]
her66.620e-1242.11hairy-related 6 [Source:ZFIN;Acc:ZDB-GENE-980526-1... [more]
her127.186e-1229.45hairy-related 12 [Source:ZFIN;Acc:ZDB-GENE-040824-... [more]
her69.565e-1242.11hairy-related 6 [Source:ZFIN;Acc:ZDB-GENE-980526-1... [more]
her8.21.764e-1040.00hairy-related 8.2 [Source:ZFIN;Acc:ZDB-GENE-060815... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dennd5b2.020e-1442.70DENN/MADD domain containing 5B [Source:Xenbase;Acc... [more]
ENSXETT00000026370.14.733e-1342.35transcription factor HES-5 [Source:NCBI gene;Acc:1... [more]
ENSXETT00000038440.11.881e-1240.00transcription factor HES-5 [Source:NCBI gene;Acc:1... [more]
ccdc636.249e-1141.84coiled-coil domain containing 63 [Source:Xenbase;A... [more]
drc31.138e-1040.70dynein regulatory complex subunit 3 [Source:Xenbas... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hes55.140e-1538.24hes family bHLH transcription factor 5 [Source:MGI... [more]
Hes17.156e-1141.84hes family bHLH transcription factor 1 [Source:MGI... [more]
Hes31.023e-1028.73hes family bHLH transcription factor 3 [Source:MGI... [more]
Hes31.463e-827.68hes family bHLH transcription factor 3 [Source:MGI... [more]
Hes23.315e-842.70hes family bHLH transcription factor 2 [Source:MGI... [more]
back to top
BLAST of hesl-2 protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q03062|HES5_RAT1.966e-1631.29Transcription factor HES-5 OS=Rattus norvegicus OX... [more]
sp|P70120|HES5_MOUSE3.595e-1438.24Transcription factor HES-5 OS=Mus musculus OX=1009... [more]
sp|Q5TA89|HES5_HUMAN6.599e-1438.24Transcription factor HES-5 OS=Homo sapiens OX=9606... [more]
sp|Q26263|DPN_DROME5.324e-1240.43Protein deadpan OS=Drosophila melanogaster OX=7227... [more]
sp|P13097|ESM7_DROME9.433e-1243.18Enhancer of split m7 protein OS=Drosophila melanog... [more]
back to top
BLAST of hesl-2 protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
U5YR732.574e-11499.39Hesl-2 protein (Fragment) OS=Schmidtea mediterrane... [more]
A0A2Y9K8876.020e-1531.10transcription factor HES-5 OS=Enhydra lutris kenyo... [more]
E2QXY93.621e-1331.10Hes family bHLH transcription factor 5 OS=Canis lu... [more]
A0A3Q7SUW33.621e-1331.10transcription factor HES-5 OS=Vulpes vulpes OX=962... [more]
A0A2Y9Q9X65.431e-1338.24transcription factor HES-5 isoform X2 OS=Delphinap... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
her34.670e-1343.82transcription factor HES-1-like [Source:NCBI gene;... [more]
hes2.16.632e-1330.51transcription factor HES-2-like [Source:NCBI gene;... [more]
her66.185e-1242.11hes family bHLH transcription factor 1 [Source:NCB... [more]
ENSAMXT00000035814.16.577e-1242.22transcription factor HES-4-B-like [Source:NCBI gen... [more]
ENSAMXT00000032867.11.417e-1029.45pep primary_assembly:Astyanax_mexicanus-2.0:22:379... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
her92.196e-1142.11hairy-related 9 [Source:ZFIN;Acc:ZDB-GENE-011213-1... [more]
her92.625e-1142.11hairy-related 9 [Source:ZFIN;Acc:ZDB-GENE-011213-1... [more]
ENSPMAT00000004472.12.876e-646.00pep scaffold:Pmarinus_7.0:GL476447:18322:19433:-1 ... [more]
bhlhe413.128e-634.38basic helix-loop-helix family, member e41 [Source:... [more]
ENSPMAT00000004474.15.650e-646.00pep scaffold:Pmarinus_7.0:GL476447:34263:35715:1 g... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of hesl-2 protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
HES42.896e-1141.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO450318.305e-1037.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
HL18.831e-852.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO432625.809e-731.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
HES26.680e-731.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of hesl-2 protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hes15.860e-1242.86hes family bHLH transcription factor 1 [Source:NCB... [more]
ENSORLT00000034583.15.976e-1139.80Her6.2 [Source:NCBI gene;Acc:100049440][more]
HES21.809e-1030.68transcription factor HES-2-like [Source:NCBI gene;... [more]
ENSORLT00000035222.12.120e-1039.77hairy/enhancer-of-split related with YRPW motif pr... [more]
ENSORLT00000043193.12.467e-1039.77hairy/enhancer-of-split related with YRPW motif pr... [more]
back to top
BLAST of hesl-2 protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000068772.11.938e-128100.00SMESG000068772.1[more]
back to top
Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30005790
GenBankAGZ94926.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005790 ID=SMED30005790|Name=hesl-2 protein|organism=Schmidtea mediterranea sexual|type=transcript|length=717bp
TTGTTATTTGTCTATTGGCATAAATAAATCAAAATTTTTTTTTACACCGG
CAAAAGTTTCAATTCAAGAATTTGAAATGTCTTCCATTCCAAATCGAATC
TCAACAAAAATCAAAAAGCAATCGCAAAGTAAACAGTTTTCGACTTTGAA
AAAGAGCAACAAACCTTTGATGGAAAGACGTCGCCGACAGAGAATAAATT
TCGCTCTCGACCAACTGAAAACTTTGTTGGAAGAAAACTCAGTGACGAAA
GAAAGTTTTGTCAAACTAGAAAAGGCGGATATTTTGGAACGAGCGGTGAA
ATTTATGACCCATACTACAGCAGAGAAGAAAAATCTCAATAAAAATCCTC
GACATCTATTAGACAGTTTCAACACTGGATATGTTGCTTGTGAAAAAGAA
ATAATGAGATTTCTTCGCAATCTCTACGGTCCGTCAAATCCATTTTTGGC
ATTGGTCTTCAACTTTCTTGAAACAAACAAAGACTCCATTAATTACAGTT
TTATTCAAAGAATTGTTCCGAACGTTAAAGTGAATGAAAAGAACATTAAC
AATTTGAAACCCGGGGAACCTTTGTCTATTGGTTCGTCTCAGTTGGATTT
GAAGTTCCTCAATCGGAGAACTTATAATTCGGTGTGGAGACCTTGGGAAA
TGTCAGTGGATAAGCTAGATGAGTGACCGGATAAATGATTTTGTAAATAA
AGATTATGAATTTTGAG
back to top

protein sequence of SMED30005790-orf-1

>SMED30005790-orf-1 ID=SMED30005790-orf-1|Name=SMED30005790-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=225bp
CYLSIGINKSKFFFTPAKVSIQEFEMSSIPNRISTKIKKQSQSKQFSTLK
KSNKPLMERRRRQRINFALDQLKTLLEENSVTKESFVKLEKADILERAVK
FMTHTTAEKKNLNKNPRHLLDSFNTGYVACEKEIMRFLRNLYGPSNPFLA
LVFNFLETNKDSINYSFIQRIVPNVKVNEKNINNLKPGEPLSIGSSQLDL
KFLNRRTYNSVWRPWEMSVDKLDE*
back to top
Aliases
The feature 'hesl-2 protein' has the following synonyms
Synonym
hesl-2
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000120progenitor cell
PLANA:0000121stem cell
PLANA:0000420parapharyngeal region
PLANA:0002109X1 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR036638HLH_DNA-bd_sf
IPR011598bHLH_dom
Vocabulary: molecular function
TermDefinition
GO:0046983protein dimerization activity
GO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677DNA binding
GO:0003682chromatin binding
GO:0003690double-stranded DNA binding
Vocabulary: biological process
TermDefinition
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006461protein complex assembly
GO:0007155cell adhesion
GO:0007219Notch signaling pathway
GO:0007224smoothened signaling pathway
GO:0007275multicellular organism development
GO:0007399nervous system development
GO:0007420brain development
GO:0008284positive regulation of cell proliferation
GO:0014003oligodendrocyte development
GO:0021537telencephalon development
GO:0021781glial cell fate commitment
GO:0021861forebrain radial glial cell differentiation
GO:0021915neural tube development
GO:0022010central nervous system myelination
GO:0030154cell differentiation
GO:0030182neuron differentiation
GO:0030513positive regulation of BMP signaling pathway
GO:0031641regulation of myelination
GO:0042491auditory receptor cell differentiation
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668auditory receptor cell fate determination
GO:0043010camera-type eye development
GO:0045595regulation of cell differentiation
GO:0045607regulation of auditory receptor cell differentiation
GO:0045665negative regulation of neuron differentiation
GO:0045747positive regulation of Notch signaling pathway
GO:0045892negative regulation of transcription, DNA-templated
GO:0045893positive regulation of transcription, DNA-templated
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0046427positive regulation of JAK-STAT cascade
GO:0048469cell maturation
GO:0048661positive regulation of smooth muscle cell proliferation
GO:0048708astrocyte differentiation
GO:0048712negative regulation of astrocyte differentiation
GO:0048715negative regulation of oligodendrocyte differentiation
GO:0050678regulation of epithelial cell proliferation
GO:0050767regulation of neurogenesis
GO:0051216cartilage development
GO:0060122inner ear receptor stereocilium organization
GO:0072049comma-shaped body morphogenesis
GO:0072050S-shaped body morphogenesis
GO:0072086specification of loop of Henle identity
GO:0072282metanephric nephron tubule morphogenesis
GO:0090162establishment of epithelial cell polarity
GO:0097150neuronal stem cell population maintenance
GO:2000737negative regulation of stem cell differentiation
GO:2000974negative regulation of pro-B cell differentiation
GO:2000978negative regulation of forebrain neuron differentiation
GO:2000981negative regulation of inner ear receptor cell differentiation
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainSMARTSM00353finuluscoord: 55..111
e-value: 1.4E-8
score: 44.5
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainPFAMPF00010HLHcoord: 50..104
e-value: 8.4E-14
score: 51.3
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainPROSITEPS50888BHLHcoord: 49..105
score: 13.764
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainCDDcd00083HLHcoord: 50..104
e-value: 1.54692E-11
score: 55.6831
IPR036638Helix-loop-helix DNA-binding domain superfamilyGENE3DG3DSA:4.10.280.10coord: 41..108
e-value: 3.4E-17
score: 64.1
IPR036638Helix-loop-helix DNA-binding domain superfamilySUPERFAMILYSSF47459HLH, helix-loop-helix DNA-binding domaincoord: 50..105
NoneNo IPR availablePANTHERPTHR10985BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATEDcoord: 38..141
NoneNo IPR availablePANTHERPTHR10985:SF12ENHANCER OF SPLIT M3 PROTEIN-RELATEDcoord: 38..141