Zinc knuckle-domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30005755 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Match: ZCCHC10 (zinc finger CCHC-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25954]) HSP 1 Score: 51.6026 bits (122), Expect = 1.666e-8 Identity = 23/53 (43.40%), Postives = 35/53 (66.04%), Query Frame = 3 Query: 81 PSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 PS + + + +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 31 PSIVISEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKEN 83
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Match: ZCCHC10 (zinc finger CCHC-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25954]) HSP 1 Score: 51.9878 bits (123), Expect = 3.211e-8 Identity = 23/52 (44.23%), Postives = 35/52 (67.31%), Query Frame = 3 Query: 81 PSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQE 236 PS + + + +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 31 PSIVISEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKE 82
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Match: ZCCHC10 (zinc finger CCHC-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25954]) HSP 1 Score: 51.9878 bits (123), Expect = 3.555e-8 Identity = 23/52 (44.23%), Postives = 35/52 (67.31%), Query Frame = 3 Query: 81 PSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQE 236 PS + + + +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 31 PSIVISEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKE 82
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Match: ZCCHC10 (zinc finger CCHC-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25954]) HSP 1 Score: 48.521 bits (114), Expect = 1.492e-7 Identity = 21/40 (52.50%), Postives = 30/40 (75.00%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 22 RCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKEN 61
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Match: ZCCHC10 (zinc finger CCHC-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25954]) HSP 1 Score: 49.2914 bits (116), Expect = 2.346e-7 Identity = 21/39 (53.85%), Postives = 30/39 (76.92%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQE 236 +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 22 RCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKE 60
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Fly
Match: CG5516 (gene:FBgn0038389 transcript:FBtr0083212) HSP 1 Score: 47.7506 bits (112), Expect = 5.400e-7 Identity = 18/43 (41.86%), Postives = 31/43 (72.09%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDEL-KELEKKQETVP 245 +CQKCL+ GHW++ECK KR +++R ++ +L K + +K+ P Sbjct: 29 RCQKCLQIGHWSYECKEKRKYVHRSSRTKQLSKRMSQKEADAP 71
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Fly
Match: CG5516 (gene:FBgn0038389 transcript:FBtr0302549) HSP 1 Score: 47.7506 bits (112), Expect = 5.400e-7 Identity = 18/43 (41.86%), Postives = 31/43 (72.09%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDEL-KELEKKQETVP 245 +CQKCL+ GHW++ECK KR +++R ++ +L K + +K+ P Sbjct: 29 RCQKCLQIGHWSYECKEKRKYVHRSSRTKQLSKRMSQKEADAP 71
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Zebrafish
Match: zcchc10 (zinc finger, CCHC domain containing 10 [Source:ZFIN;Acc:ZDB-GENE-030131-6172]) HSP 1 Score: 48.1358 bits (113), Expect = 4.249e-7 Identity = 20/43 (46.51%), Postives = 30/43 (69.77%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVPA 248 +CQKCLE GHW++EC KR +L R ++ E+K+ K +E P+ Sbjct: 22 RCQKCLEFGHWSYECTGKRKYLYRPSRTAEMKKKLKDKENNPS 64
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Xenopus
Match: unc13c (unc-13 homolog C [Source:Xenbase;Acc:XB-GENE-6044557]) HSP 1 Score: 51.6026 bits (122), Expect = 6.928e-8 Identity = 24/64 (37.50%), Postives = 38/64 (59.38%), Query Frame = 3 Query: 57 VFENIRKLPSFLAKKDEESIS---KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +F+ + +A++ E+ +CQKCLE GHW++EC KR +L R T+ ELK K++E Sbjct: 40 LFDMATPMHRLIARRQAEANKQNVRCQKCLEMGHWSYECTGKRKYLYRPTRTTELKRALKEKEA 103
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Mouse
Match: Zcchc10 (zinc finger, CCHC domain containing 10 [Source:MGI Symbol;Acc:MGI:1196228]) HSP 1 Score: 50.8322 bits (120), Expect = 5.229e-8 Identity = 22/40 (55.00%), Postives = 31/40 (77.50%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +CQKCLE GHWT+ECK KR +L+R ++ ELK+ K++E Sbjct: 22 RCQKCLEFGHWTYECKGKRKYLHRPSRTAELKKALKEKEN 61
BLAST of Zinc knuckle-domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8TBK6|ZCH10_HUMAN (Zinc finger CCHC domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZCCHC10 PE=1 SV=1) HSP 1 Score: 51.9878 bits (123), Expect = 1.542e-7 Identity = 23/52 (44.23%), Postives = 35/52 (67.31%), Query Frame = 3 Query: 81 PSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQE 236 PS + + + +CQKCLE GHWT+EC KR +L+R ++ ELK+ K++E Sbjct: 31 PSIVISEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKE 82
BLAST of Zinc knuckle-domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CX48|ZCH10_MOUSE (Zinc finger CCHC domain-containing protein 10 OS=Mus musculus OX=10090 GN=Zcchc10 PE=2 SV=1) HSP 1 Score: 50.8322 bits (120), Expect = 3.658e-7 Identity = 22/40 (55.00%), Postives = 31/40 (77.50%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +CQKCLE GHWT+ECK KR +L+R ++ ELK+ K++E Sbjct: 22 RCQKCLEFGHWTYECKGKRKYLHRPSRTAELKKALKEKEN 61
BLAST of Zinc knuckle-domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5EB97|ZCH10_RAT (Zinc finger CCHC domain-containing protein 10 OS=Rattus norvegicus OX=10116 GN=Zcchc10 PE=2 SV=2) HSP 1 Score: 50.8322 bits (120), Expect = 3.996e-7 Identity = 22/40 (55.00%), Postives = 31/40 (77.50%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +CQKCLE GHWT+ECK KR +L+R ++ ELK+ K++E Sbjct: 22 RCQKCLEFGHWTYECKGKRKYLHRPSRTAELKKALKEKEN 61
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Match: A0A2R7WL34 (Uncharacterized protein OS=Oncopeltus fasciatus OX=7536 GN=OFAS_OFAS009228 PE=4 SV=1) HSP 1 Score: 55.4546 bits (132), Expect = 2.287e-7 Identity = 27/56 (48.21%), Postives = 35/56 (62.50%), Query Frame = 3 Query: 96 KKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDE----LKELEKKQETVPAV 251 K + +KCQKCLE GHWT+ECK KR FLNR ++ + LK +E+KQ A Sbjct: 12 KSSQPQTAKCQKCLEVGHWTYECKGKRKFLNRSSRTAQLNKRLKLIEEKQNGTAAT 67
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Match: A0A023F769 (Putative zinc finger cchc domain-containing protein 10 OS=Triatoma infestans OX=30076 PE=2 SV=1) HSP 1 Score: 56.225 bits (134), Expect = 3.647e-7 Identity = 25/47 (53.19%), Postives = 33/47 (70.21%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCD----ELKELEKKQETVPA 248 KCQKCLE+GHWT+ECK KR FLNR ++ +K LE K++ +P Sbjct: 20 KCQKCLESGHWTYECKGKRKFLNRSSRSSLLNKRMKALEDKEKDIPP 66
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Match: A0A067R1R1 (Zinc finger CCHC domain-containing protein 10 OS=Zootermopsis nevadensis OX=136037 GN=L798_09284 PE=4 SV=1) HSP 1 Score: 53.9138 bits (128), Expect = 8.223e-7 Identity = 27/56 (48.21%), Postives = 39/56 (69.64%), Query Frame = 3 Query: 84 SFLAKKDE--ESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKE-LEKKQETV 242 LAKK+ ++CQKCLE GHWTFECK KR +L+R ++ +LK+ L+ ++E V Sbjct: 7 GMLAKKNSYPPQGARCQKCLEYGHWTFECKGKRKYLHRSSRTSQLKKRLKLREEAV 62
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Match: A0A151WN89 (Zinc finger CCHC domain-containing protein 10 (Fragment) OS=Trachymyrmex zeteki OX=64791 GN=ALC60_11615 PE=4 SV=1) HSP 1 Score: 53.1434 bits (126), Expect = 1.312e-6 Identity = 21/40 (52.50%), Postives = 31/40 (77.50%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQET 239 +CQKCLE GHW++ECK KR +L+R ++ +LK+ +KQE Sbjct: 8 RCQKCLEMGHWSYECKGKRKYLHRSSRTSQLKKAMQKQEN 47
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Match: A0A3B6RL00 (Uncharacterized protein OS=Triticum aestivum OX=4565 PE=4 SV=1) HSP 1 Score: 56.9954 bits (136), Expect = 1.593e-6 Identity = 21/44 (47.73%), Postives = 34/44 (77.27%), Query Frame = 3 Query: 117 SKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVPA 248 +CQKC + GHWT+ECKN+RV+++R ++ D+LK+ K+ +PA Sbjct: 89 GQCQKCFQPGHWTYECKNERVYISRPSRTDQLKDPRLKKAWLPA 132
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000052589.1 (zinc finger CCHC-type containing 10 [Source:NCBI gene;Acc:103022142]) HSP 1 Score: 50.0618 bits (118), Expect = 7.539e-8 Identity = 22/45 (48.89%), Postives = 30/45 (66.67%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDE----LKELEKKQETV 242 +CQKCLE GHW++EC KR +L R ++ E LKE+E K +V Sbjct: 22 RCQKCLEYGHWSYECTGKRKYLYRPSRTSEMKKKLKEMENKDPSV 66
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008415.1 (pep scaffold:Pmarinus_7.0:GL476642:71986:80050:-1 gene:ENSPMAG00000007613.1 transcript:ENSPMAT00000008415.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 46.595 bits (109), Expect = 2.578e-7 Identity = 25/63 (39.68%), Postives = 36/63 (57.14%), Query Frame = 3 Query: 54 MVFENIRKLPSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCD----ELKELEKK 230 M R L A D+E++ +CQKCLE GHWT+EC + R + R T+ +LKEL ++ Sbjct: 1 MATPMHRLLARRKADADKETV-RCQKCLELGHWTYECSSTRAYKQRPTRTALLQRQLKELTQR 62
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Nematostella
Match: EDO28323 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6T1]) HSP 1 Score: 45.8246 bits (107), Expect = 1.038e-7 Identity = 18/32 (56.25%), Postives = 24/32 (75.00%), Query Frame = 3 Query: 105 EESISKCQKCLETGHWTFECKNKRVFLNRKTK 200 E KCQKCL+ GHWT+EC NKR +L+R ++ Sbjct: 1 EAGKQKCQKCLQIGHWTYECTNKRKYLHRMSR 32
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000001697.2 (zinc finger CCHC-type containing 10 [Source:NCBI gene;Acc:101167387]) HSP 1 Score: 47.7506 bits (112), Expect = 4.612e-7 Identity = 20/42 (47.62%), Postives = 30/42 (71.43%), Query Frame = 3 Query: 120 KCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVP 245 +CQKCLE GHWT+EC KR +++R ++ E+K+ K+ E P Sbjct: 22 RCQKCLELGHWTYECTGKRKYVHRPSRTVEMKKKLKEVENKP 63
BLAST of Zinc knuckle-domain-containing protein vs. Planmine SMEST
Match: SMESG000050169.1 (SMESG000050169.1) HSP 1 Score: 155.221 bits (391), Expect = 4.203e-49 Identity = 135/138 (97.83%), Postives = 137/138 (99.28%), Query Frame = 3 Query: 54 MVFENIRKLPSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVPAVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPTVPKKKLKISENK 467 MVFENIRKLPSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVPAVDEYAEDSD+LSSDDSSSTSSSNDSSKSNSNAASSSDSDTSSSSDSDTSSSSDSSSSE+P VPKKKLKISENK Sbjct: 1 MVFENIRKLPSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCDELKELEKKQETVPAVDEYAEDSDTLSSDDSSSTSSSNDSSKSNSNAASSSDSDTSSSSDSDTSSSSDSSSSETPIVPKKKLKISENK 138 The following BLAST results are available for this feature:
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 3
BLAST of Zinc knuckle-domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Zinc knuckle-domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30005755 ID=SMED30005755|Name=Zinc knuckle-domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=497bpback to top protein sequence of SMED30005755-orf-1 >SMED30005755-orf-1 ID=SMED30005755-orf-1|Name=SMED30005755-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=139bp MVFENIRKLPSFLAKKDEESISKCQKCLETGHWTFECKNKRVFLNRKTKCback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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