HNF4

Overview


Name	HNF4 (AFF18489.1)
Smed ID	SMED30005748
Length (bp)	3066

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of HNF4 (SMED30005748) t-SNE clustered cells

Violin plots show distribution of expression levels for HNF4 (SMED30005748) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HNF4 (SMED30005748) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HNF4 (SMED30005748) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Expression Details

HNF4 ( hnf-4 ) is expressed during Stage 2, Stage 5, Stage 6, Stage 7 and Stage 8 in the embryonic digestive system, digestive system, embryonic pharynx, gut and gamma neoblast

Click to see image symbols and abbreviations


Abbreviation or symbol	Definition
O	oral hemisphere
A	aboral hemisphere
D	dorsal
V	ventral
L	lateral
black arrowhead	embryonic pharynx
red arrowhead	definitive pharynx
black arrows	primitive gut
yellow arrows	primitive ectoderm cells
cyan arrows	brain
cyan arrowheads	nerve cords
blue arrowheads	eye progenitors (trail cells)
purple arrowheads	eyes
scale bar	100 µm

Anatomical Expression

PAGE et. al., 2020

SMED30005748

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 39

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30005748	h1SMcG0019688	Contig5288	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gamma neoblast	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:29906446 Zeng et al., 2018
pharynx	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30005748	h1SMcG0019688	dd_Smed_v4_1694_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30005748	h1SMcG0019688	Contig43272	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30005748	h1SMcG0019688	Contig43272	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30005748	h1SMcG0019688	Contig39171	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30005748	h1SMcG0019688	Contig39171	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
gut	SMED30005748	h1SMcG0019688	JF802199	smed_ncbi_20240424	PMID:21566185 Wagner et al., 2011
gastrodermal cell	SMED30005748	h1SMcG0019688	JF802199	smed_ncbi_20240424	PMID:21566185 Wagner et al., 2011
gut	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:21566185 Wagner et al., 2011
gastrodermal cell	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:21566185 Wagner et al., 2011
gamma neoblast	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:30194301 Mihaylova et al., 2018
gamma neoblast	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:30194301 Mihaylova et al., 2018
embryonic pharynx	SMED30005748	h1SMcG0019688	AFF18489.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	AFF18489.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	AFF18489.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	AFF18489.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	AFF18489.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
embryonic pharynx	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:28072387 Davies et al., 2017
embryonic pharynx	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	SMED30005748	smed_20140614	PMID:28072387 Davies et al., 2017
gut	SMED30005748	h1SMcG0019688	hnf4	smed_ncbi_20240424	PMID:25254346 Scimone et al., 2014
gamma neoblast	SMED30005748	h1SMcG0019688	JF802199.1	smed_ncbi_20240424	PMID:25017721 van Wolfswinkel et al., 2014
progenitor cell	SMED30005748	h1SMcG0019688	dd_Smed_v6_1694_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
pigment cell	SMED30005748	h1SMcG0019688	dd_Smed_v6_1694_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
parenchymal cell	SMED30005748	h1SMcG0019688	dd_Smed_v6_1694_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of HNF4 vs. Ensembl Human
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026])

HSP 1 Score: 350.903 bits (899), Expect = 2.555e-110
Identity = 178/344 (51.74%), Postives = 244/344 (70.93%), Query Frame = -1

Query:  946 ASNASGPEGMEN------NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQR---VAIQKPPNPQEY-MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1938
            +S++S PE   N      N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+FD  +IP     SI+ L QAE R   +++  P +  +  + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGNN +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:   28 SSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIP-----SINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 364

[Close]

BLAST of HNF4 vs. Ensembl Human
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026])

HSP 1 Score: 351.288 bits (900), Expect = 2.584e-110
Identity = 178/344 (51.74%), Postives = 244/344 (70.93%), Query Frame = -1

Query:  946 ASNASGPEGMEN------NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQR---VAIQKPPNPQEY-MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1938
            +S++S PE   N      N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+FD  +IP     SI+ L QAE R   +++  P +  +  + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGNN +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:   38 SSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIP-----SINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 374

[Close]

BLAST of HNF4 vs. Ensembl Human
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026])

HSP 1 Score: 347.051 bits (889), Expect = 2.412e-109
Identity = 173/326 (53.07%), Postives = 236/326 (72.39%), Query Frame = -1

Query:  946 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQR---VAIQKPPNPQEY-MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1902
            N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+FD  +IP     SI+ L QAE R   +++  P +  +  + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGNN +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:    9 NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIP-----SINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 327

[Close]

BLAST of HNF4 vs. Ensembl Human
Match: HNF4A (hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024])

HSP 1 Score: 345.895 bits (886), Expect = 1.702e-108
Identity = 177/344 (51.45%), Postives = 246/344 (71.51%), Query Frame = -1

Query:  937 ASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNP 1938
             +N + P  +  + LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      DVLLLGN+ I+ R+  +    + ++  ILD+L +P +ELQ+DD E+A LKAI+FFDP    +S+ GK  ++R R Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG +P
Sbjct:   23 GTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALLQAE--VLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK--IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSP 357

[Close]

BLAST of HNF4 vs. Ensembl Human
Match: HNF4A (hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024])

HSP 1 Score: 345.895 bits (886), Expect = 2.697e-108
Identity = 177/344 (51.45%), Postives = 246/344 (71.51%), Query Frame = -1

Query:  937 ASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNP 1938
             +N + P  +  + LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      DVLLLGN+ I+ R+  +    + ++  ILD+L +P +ELQ+DD E+A LKAI+FFDP    +S+ GK  ++R R Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG +P
Sbjct:   23 GTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALLQAE--VLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK--IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSP 357

[Close]

BLAST of HNF4 vs. Ensembl Celegans
Match: nhr-69 (Nuclear hormone receptor family member nhr-69 [Source:UniProtKB/Swiss-Prot;Acc:P91829])

HSP 1 Score: 226.483 bits (576), Expect = 1.148e-65
Identity = 129/344 (37.50%), Postives = 194/344 (56.40%), Query Frame = -1

Query:  934 QLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVI---LSISQLMQAEQRVAIQKPPNPQEY----------MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK--HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHK------PGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPP 1899
            ++C IC+DK+TGKHYGA SCDGCKGFFRRS+RK+ +Y C++ +NC + K+KRN CR CRL+KC+  GMK  A+QNERD I  R+ +      ++I   ++   L Q  +   I+   +   Y            R A + D+ +S+  QL L + WAKSLP FS L  +DQ +LLK  A  I++LGV  RS  L  ++ + L N+ ++ +  + +      +   I+D++  P+R L +D  E+  LKAI+FF+P V E + +  V   RY     L     DK            R G+LLL +P L+ + Q +V+ V+  ++ GL  +DSL+ E +L D  P
Sbjct:    4 EICHICNDKSTGKHYGAISCDGCKGFFRRSIRKRYHYQCRFEQNCDVTKNKRNACRACRLQKCVKAGMKSNAIQNERDAIGKRKKTTGAEKEDLIDQLVAAETLCQQLRSSVIKNTSSLAPYDCGKVKWNYEDARAATLDDIGKSIHQQLVLFIEWAKSLPQFSFLAQADQAALLKGGAASIIVLGVAYRSICLTVENTICLANDTLLPKEHATQVGDINCVVGRIIDEIVNPMRRLNMDLIEYVALKAILFFNPVVREINDQSPVENARYAFLRSLQRRCTDKALENMEDESMDCRSGKLLLLLPSLQAIAQQLVEDVQLARLFGLVNVDSLMEELILNDMKP 347

[Close]

BLAST of HNF4 vs. Ensembl Celegans
Match: nhr-64 (Nuclear hormone receptor family member nhr-64 [Source:UniProtKB/Swiss-Prot;Acc:O44960])

HSP 1 Score: 194.512 bits (493), Expect = 2.023e-54
Identity = 121/330 (36.67%), Postives = 180/330 (54.55%), Query Frame = -1

Query:  949 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRIS-----TRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPR----VSESGKEFVRRCRYQIQMDLMNHMNDKQYHK--PGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLL 1902
            N  C IC D+ATGKHYGA SCDGCKGFFRR++RK+++Y C++   C++DK KRN CR CR   C+  GM+R AVQ ERDRI      +  S+   +P + +L      +A  R              + A   DV +SM  QL L+V WAK L  F +++   Q++LL+  + + L++    RS  L   D + L N   + ++S        +A  I+D +  P+R L +++ E+  LKAI FFDP      SES  + V   R +I      H+     +K  P RF  LLL +P +  +++ +V+ V+  K+ GLA ID+L+ E +L
Sbjct:   30 NVFCAICGDRATGKHYGAMSCDGCKGFFRRTIRKRHSYVCRFGEKCQVDKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHL--SDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSD-VEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELML 356

[Close]

BLAST of HNF4 vs. Ensembl Celegans
Match: nhr-64 (Nuclear hormone receptor family member nhr-64 [Source:UniProtKB/Swiss-Prot;Acc:O44960])

HSP 1 Score: 194.126 bits (492), Expect = 2.247e-54
Identity = 121/330 (36.67%), Postives = 180/330 (54.55%), Query Frame = -1

Query:  949 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRIS-----TRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPR----VSESGKEFVRRCRYQIQMDLMNHMNDKQYHK--PGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLL 1902
            N  C IC D+ATGKHYGA SCDGCKGFFRR++RK+++Y C++   C++DK KRN CR CR   C+  GM+R AVQ ERDRI      +  S+   +P + +L      +A  R              + A   DV +SM  QL L+V WAK L  F +++   Q++LL+  + + L++    RS  L   D + L N   + ++S        +A  I+D +  P+R L +++ E+  LKAI FFDP      SES  + V   R +I      H+     +K  P RF  LLL +P +  +++ +V+ V+  K+ GLA ID+L+ E +L
Sbjct:   24 NVFCAICGDRATGKHYGAMSCDGCKGFFRRTIRKRHSYVCRFGEKCQVDKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHL--SDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSD-VEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELML 350

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Query:  949 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRIS-----TRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPR----VSESGKEFVRRCRYQIQMDLMNHMNDKQYHK--PGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLL 1902
            N  C IC D+ATGKHYGA SCDGCKGFFRR++RK+++Y C++   C++DK KRN CR CR   C+  GM+R AVQ ERDRI      +  S+   +P + +L      +A  R              + A   DV +SM  QL L+V WAK L  F +++   Q++LL+  + + L++    RS  L   D + L N   + ++S        +A  I+D +  P+R L +++ E+  LKAI FFDP      SES  + V   R +I      H+     +K  P RF  LLL +P +  +++ +V+ V+  K+ GLA ID+L+ E +L
Sbjct:   24 NVFCAICGDRATGKHYGAMSCDGCKGFFRRTIRKRHSYVCRFGEKCQVDKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHL--SDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSD-VEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELML 350

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BLAST of HNF4 vs. Ensembl Celegans
Match: nhr-35 (Nuclear hormone receptor family member nhr-35 [Source:UniProtKB/Swiss-Prot;Acc:Q17771])

HSP 1 Score: 196.052 bits (497), Expect = 8.280e-54
Identity = 126/385 (32.73%), Postives = 192/385 (49.87%), Query Frame = -1

Query:  931 VYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSS-------FDDIP---PNVILS---------ISQLMQAEQRVA---------------IQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSS---------DKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFD---PRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGEL-LLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPG 1944
             Y  ++      ++N +C ICSD ATG+HYGA +C+GCKGFFRR+VR+   Y C++   C++DK  R  CRYCR  KCI  GM+   VQ+ERD I  R           D  P   P + +S         +  L+++E  +                  K  N   + +R A + DV +SM +QL L++ WAK+LP F QL+ +DQ  LLK  AG+ + L V  RS  +  +D L L N+L I R S          D  +      ++D L  P+R L+LD+ EF  LKA V F+   P +S      V   R +I      ++   +  +  R G+L    +  L ++++ + + + F K++G+A ID L+ E +L +   G
Sbjct:    4 TYNGDSKAETDGKDNSICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISSGMRDDQVQSERDVIGKREKKDNMKTYCQDPTPRTSPELTMSPVEDEYDQLLESLLKSEMTIQSLRDTVITQTGNVEYTTKSKNRLSHTDRTATLNDVLKSMHSQLLLVIEWAKTLPEFKQLSGADQAVLLKNFAGQHVTLCVAYRS--VGANDALKLLNDLYIPRASKTTPHLKEYVDGFYLRDCEKVMDQLVEPMRFLKLDNKEFVALKACVLFNPVAPGLSNHAVNLVLNARRKIFAAFEKYVRVNKPLETTRVGDLTFFILTPLSVLSKSISEDIMFTKVSGVARIDVLMEELILAETDYG 386

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BLAST of HNF4 vs. Ensembl Fly
Match: Hnf4 (gene:FBgn0004914 transcript:FBtr0344784)

HSP 1 Score: 340.502 bits (872), Expect = 6.502e-104
Identity = 171/338 (50.59%), Postives = 232/338 (68.64%), Query Frame = -1

Query:  937 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE-----QRVAIQKPPNPQEYMN--RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK------HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG----DNP 1896
            +C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC++ RNC +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RR+S DD  P   LS+  L++AE      +      PN  E ++  ++A + DVCESMK QL  LV WAK +P F++L L DQ++LL+AHAGE L+LG+ RRS  L   DVLLL NN +I+R+  D         + I + I+D+L   ++++ +DD EFAC+KA+VFFDP      +   ++  R+QI  +L ++++D+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A IDSLL E LLG    DNP
Sbjct:  103 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL--KDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 438

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BLAST of HNF4 vs. Ensembl Fly
Match: Hnf4 (gene:FBgn0004914 transcript:FBtr0079747)

HSP 1 Score: 340.502 bits (872), Expect = 1.586e-103
Identity = 171/338 (50.59%), Postives = 232/338 (68.64%), Query Frame = -1

Query:  937 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE-----QRVAIQKPPNPQEYMN--RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK------HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG----DNP 1896
            +C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC++ RNC +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RR+S DD  P   LS+  L++AE      +      PN  E ++  ++A + DVCESMK QL  LV WAK +P F++L L DQ++LL+AHAGE L+LG+ RRS  L   DVLLL NN +I+R+  D         + I + I+D+L   ++++ +DD EFAC+KA+VFFDP      +   ++  R+QI  +L ++++D+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A IDSLL E LLG    DNP
Sbjct:  141 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL--KDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 476

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BLAST of HNF4 vs. Ensembl Fly
Match: Hnf4 (gene:FBgn0004914 transcript:FBtr0336633)

HSP 1 Score: 340.502 bits (872), Expect = 1.586e-103
Identity = 171/338 (50.59%), Postives = 232/338 (68.64%), Query Frame = -1

Query:  937 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE-----QRVAIQKPPNPQEYMN--RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK------HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG----DNP 1896
            +C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC++ RNC +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RR+S DD  P   LS+  L++AE      +      PN  E ++  ++A + DVCESMK QL  LV WAK +P F++L L DQ++LL+AHAGE L+LG+ RRS  L   DVLLL NN +I+R+  D         + I + I+D+L   ++++ +DD EFAC+KA+VFFDP      +   ++  R+QI  +L ++++D+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A IDSLL E LLG    DNP
Sbjct:  141 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL--KDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 476

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BLAST of HNF4 vs. Ensembl Fly
Match: Hnf4 (gene:FBgn0004914 transcript:FBtr0112846)

HSP 1 Score: 340.502 bits (872), Expect = 1.718e-103
Identity = 171/338 (50.59%), Postives = 232/338 (68.64%), Query Frame = -1

Query:  937 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE-----QRVAIQKPPNPQEYMN--RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK------HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG----DNP 1896
            +C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC++ RNC +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RR+S DD  P   LS+  L++AE      +      PN  E ++  ++A + DVCESMK QL  LV WAK +P F++L L DQ++LL+AHAGE L+LG+ RRS  L   DVLLL NN +I+R+  D         + I + I+D+L   ++++ +DD EFAC+KA+VFFDP      +   ++  R+QI  +L ++++D+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A IDSLL E LLG    DNP
Sbjct:  145 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL--KDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 480

[Close]

BLAST of HNF4 vs. Ensembl Fly
Match: Hnf4 (gene:FBgn0004914 transcript:FBtr0079748)

HSP 1 Score: 340.887 bits (873), Expect = 2.359e-103
Identity = 171/338 (50.59%), Postives = 232/338 (68.64%), Query Frame = -1

Query:  937 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE-----QRVAIQKPPNPQEYMN--RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK------HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG----DNP 1896
            +C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC++ RNC +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RR+S DD  P   LS+  L++AE      +      PN  E ++  ++A + DVCESMK QL  LV WAK +P F++L L DQ++LL+AHAGE L+LG+ RRS  L   DVLLL NN +I+R+  D         + I + I+D+L   ++++ +DD EFAC+KA+VFFDP      +   ++  R+QI  +L ++++D+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A IDSLL E LLG    DNP
Sbjct:  169 VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHL--KDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNP 504

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BLAST of HNF4 vs. Ensembl Zebrafish
Match: hnf4a (hepatocyte nuclear factor 4, alpha [Source:ZFIN;Acc:ZDB-GENE-030131-1077])

HSP 1 Score: 352.058 bits (902), Expect = 9.728e-111
Identity = 183/361 (50.69%), Postives = 250/361 (69.25%), Query Frame = -1

Query:  946 SVVLYKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 2007
            + + ++  Q++ +S  S   E    NA+   G     LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++NR C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II RN  +   + +A  ILD+L +P ++LQ+DD E+ACLKAIVFFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   24 TTLEFENMQVLAMSTDSSPQESANMNAANHLGA--GTLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VLSRQISSPGPILNGDIRTKKVAAIMDVCESMKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMMY--KDILLLGNDHIIPRNCPELEVSRVAVRILDELVLPFQDLQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

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Query:  946 SVVLYKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 2007
            + + ++  Q++ +S  S   E    NA+   G     LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++NR C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II RN  +   + +A  ILD+L +P ++LQ+DD E+ACLKAIVFFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   24 TTLEFENMQVLAMSTDSSPQESANMNAANHLGA--GTLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VLSRQISSPGPILNGDIRTKKVAAIMDVCESMKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMMY--KDILLLGNDHIIPRNCPELEVSRVAVRILDELVLPFQDLQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

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Query:  946 SVVLYKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 2007
            + + ++  Q++ +S  S   E    NA+   G     LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++NR C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II RN  +   + +A  ILD+L +P ++LQ+DD E+ACLKAIVFFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   24 TTLEFENMQVLAMSTDSSPQESANMNAANHLGA--GTLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VLSRQISSPGPILNGDIRTKKVAAIMDVCESMKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMMY--KDILLLGNDHIIPRNCPELEVSRVAVRILDELVLPFQDLQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

[Close]

BLAST of HNF4 vs. Ensembl Zebrafish
Match: hnf4g (hepatocyte nuclear factor 4, gamma [Source:ZFIN;Acc:ZDB-GENE-060929-100])

HSP 1 Score: 340.117 bits (871), Expect = 1.086e-106
Identity = 170/332 (51.20%), Postives = 234/332 (70.48%), Query Frame = -1

Query:  946 ASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRY-ADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1929
            + G  G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + Y+C++NR C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RR+  D  D+PP   L+ ++ +   Q++    P  P +   +  A + DVCESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS  +   D+LLLGN  +I RN  +     +++ +LD+L +P +++Q+DD E+A LKAIVFFDP   S      ++  RYQ+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:   19 SQGENGVSSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFNRQCVVDKDKRNQCRFCRLHKCFRAGMKKEAVQNERDRISSRRNIQDSHDLPPITALAHAEAL--SQQITAASPMGPADVSEKKSATISDVCESMKQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRS--MSYKDLLLLGNGCVIHRNCPEPEIGRVSNRVLDELVLPFQDIQIDDNEYAALKAIVFFDPDAKSLRDPSKIKAMRYQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLFGLAKIDNLLQEMLLG 344

[Close]

BLAST of HNF4 vs. Ensembl Zebrafish
Match: hnf4g (hepatocyte nuclear factor 4, gamma [Source:ZFIN;Acc:ZDB-GENE-060929-100])

HSP 1 Score: 340.887 bits (873), Expect = 1.396e-106
Identity = 170/332 (51.20%), Postives = 236/332 (71.08%), Query Frame = -1

Query:  946 ASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRY-ADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1929
            + G  G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + Y+C++NR C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RR+  D  D+PP   L+ ++ + ++Q++    P  P +   +  A + DVCESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS  +   D+LLLGN  +I RN  +     +++ +LD+L +P +++Q+DD E+A LKAIVFFDP   S      ++  RYQ+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:   52 SQGENGVSSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFNRQCVVDKDKRNQCRFCRLHKCFRAGMKKEAVQNERDRISSRRNIQDSHDLPPITALAHAEAL-SQQQITAASPMGPADVSEKKSATISDVCESMKQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRS--MSYKDLLLLGNGCVIHRNCPEPEIGRVSNRVLDELVLPFQDIQIDDNEYAALKAIVFFDPDAKSLRDPSKIKAMRYQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLFGLAKIDNLLQEMLLG 378

[Close]

BLAST of HNF4 vs. Ensembl Xenopus
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:NCBI gene;Acc:100486239])

HSP 1 Score: 355.91 bits (912), Expect = 4.793e-112
Identity = 180/346 (52.02%), Postives = 241/346 (69.65%), Query Frame = -1

Query:  946 VYASNASGPEGMEN--------NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE----QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1944
            +Y  + S PEG  N        N +C IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTR+S+F+    ++I SI+ L QAE    Q  A     N +    + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LGV +RS      D+L LGNN +I RN S+   + +AS +LD+L +P +E+Q+DD E+ACLKAIVFFDP     S    ++  RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++V+F+K+ G+ +ID+LL E LLG
Sbjct:   36 LYNDSDSSPEGSANMNSLDNGINSMCAICGDRATGKHYGASSCDGCKGFFRRSIRKCHVYSCRFSRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRKSAFEG---SIIPSINTLSQAEVLSRQITASSPDANTEINTKKIASISDVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEQLLLGVTKRSMVF--KDILFLGNNYVIHRNCSEMEISRVASRVLDELVLPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPIKIKTMRYQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQVQFVKLFGMVKIDNLLQEMLLG 376

[Close]

BLAST of HNF4 vs. Ensembl Xenopus
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:NCBI gene;Acc:100486239])

HSP 1 Score: 355.91 bits (912), Expect = 5.494e-112
Identity = 179/346 (51.73%), Postives = 240/346 (69.36%), Query Frame = -1

Query:  946 VYASNASGPEGMEN--------NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE----QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEF-VRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1944
            +Y  + S PEG  N        N +C IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTR+S+F+    ++I SI+ L QAE    Q  A     N +    + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LGV +RS      D+L LGNN +I RN S+   + +AS +LD+L +P +E+Q+DD E+ACLKAIVFFDP          ++  RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++V+F+K+ G+ +ID+LL E LLG
Sbjct:   34 LYNDSDSSPEGSANMNSLDNGINSMCAICGDRATGKHYGASSCDGCKGFFRRSIRKCHVYSCRFSRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRKSAFEG---SIIPSINTLSQAEVLSRQITASSPDANTEINTKKIASISDVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEQLLLGVTKRSMVF--KDILFLGNNYVIHRNCSEMEISRVASRVLDELVLPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPIKIKTMRYQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQVQFVKLFGMVKIDNLLQEMLLG 374

[Close]

BLAST of HNF4 vs. Ensembl Xenopus
Match: HNF4G (hepatocyte nuclear factor 4 gamma [Source:NCBI gene;Acc:100486239])

HSP 1 Score: 353.599 bits (906), Expect = 9.157e-112
Identity = 179/340 (52.65%), Postives = 238/340 (70.00%), Query Frame = -1

Query:  946 SGPEGMEN--------NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE----QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1926
            S PEG  N        N +C IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTR+S+F+    ++I SI+ L QAE    Q  A     N +    + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LGV +RS      D+L LGNN +I RN S+   + +AS +LD+L +P +E+Q+DD E+ACLKAIVFFDP     S    ++  RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++V+F+K+ G+ +ID+LL E LLG
Sbjct:    8 SSPEGSANMNSLDNGINSMCAICGDRATGKHYGASSCDGCKGFFRRSIRKCHVYSCRFSRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRKSAFEG---SIIPSINTLSQAEVLSRQITASSPDANTEINTKKIASISDVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEQLLLGVTKRSMVF--KDILFLGNNYVIHRNCSEMEISRVASRVLDELVLPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPIKIKTMRYQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQVQFVKLFGMVKIDNLLQEMLLG 342

[Close]

BLAST of HNF4 vs. Ensembl Xenopus
Match: HNF4A (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:100492541])

HSP 1 Score: 354.369 bits (908), Expect = 2.591e-111
Identity = 180/357 (50.42%), Postives = 250/357 (70.03%), Query Frame = -1

Query:  946 YKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1995
            ++  Q++ +   +   +V + NA+   G+  N LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  Q+  +    +N      + A + DVC+SMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RN  +     +A  ILD+L +P +ELQ+DD E+ACLKAI+FFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   30 FENMQVLSIGTDTSPSDVTSLNATNSIGV--NSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINVLIQAE--VLSQQITSSVGVLNTDIRGKKIASITDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNDRVIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPTKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 377

[Close]

BLAST of HNF4 vs. Ensembl Xenopus
Match: HNF4A (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:100492541])

HSP 1 Score: 352.443 bits (903), Expect = 3.243e-111
Identity = 180/357 (50.42%), Postives = 250/357 (70.03%), Query Frame = -1

Query:  946 YKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1995
            ++  Q++ +   +   +V + NA+   G+  N LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  Q+  +    +N      + A + DVC+SMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RN  +     +A  ILD+L +P +ELQ+DD E+ACLKAI+FFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   28 FENMQVLSIGTDTSPSDVTSLNATNSIGV--NSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINVLIQAE--VLSQQITSSVGVLNTDIRGKKIASITDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNDRVIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPTKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

[Close]

BLAST of HNF4 vs. Ensembl Mouse
Match: Hnf4g (hepatocyte nuclear factor 4, gamma [Source:MGI Symbol;Acc:MGI:1353604])

HSP 1 Score: 344.739 bits (883), Expect = 1.798e-108
Identity = 171/326 (52.45%), Postives = 233/326 (71.47%), Query Frame = -1

Query:  946 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEY----MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1902
            N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+++  +IP     SI+ L QAE R      P+P       + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:   19 NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTYEGSNIP-----SINTLAQAEVRSCQISVPSPSSSTDINIKKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNHYVIHRNSCEVEVSRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 337

[Close]

BLAST of HNF4 vs. Ensembl Mouse
Match: Hnf4g (hepatocyte nuclear factor 4, gamma [Source:MGI Symbol;Acc:MGI:1353604])

HSP 1 Score: 345.125 bits (884), Expect = 5.097e-108
Identity = 171/326 (52.45%), Postives = 233/326 (71.47%), Query Frame = -1

Query:  946 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEY----MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1902
            N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+++  +IP     SI+ L QAE R      P+P       + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:   63 NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTYEGSNIP-----SINTLAQAEVRSCQISVPSPSSSTDINIKKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNHYVIHRNSCEVEVSRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 381

[Close]

BLAST of HNF4 vs. Ensembl Mouse
Match: Hnf4a (hepatic nuclear factor 4, alpha [Source:MGI Symbol;Acc:MGI:109128])

HSP 1 Score: 344.739 bits (883), Expect = 6.082e-108
Identity = 176/327 (53.82%), Postives = 240/327 (73.39%), Query Frame = -1

Query:  946 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1896
            LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  Q+  +P   +N      + A++ DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      DVLLLGN+ I+ R+  +    + ++  ILD+L +P +ELQ+DD E+ACLKAI+FFDP    +S+ GK  ++R R Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   50 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALLQAE--VLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGK--IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLG 367

[Close]

BLAST of HNF4 vs. Ensembl Mouse
Match: Hnf4a (hepatic nuclear factor 4, alpha [Source:MGI Symbol;Acc:MGI:109128])

HSP 1 Score: 344.739 bits (883), Expect = 9.105e-108
Identity = 176/327 (53.82%), Postives = 240/327 (73.39%), Query Frame = -1

Query:  946 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1896
            LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  Q+  +P   +N      + A++ DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      DVLLLGN+ I+ R+  +    + ++  ILD+L +P +ELQ+DD E+ACLKAI+FFDP    +S+ GK  ++R R Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALLQAE--VLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGK--IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLG 376

[Close]

BLAST of HNF4 vs. Ensembl Mouse
Match: Rxra (retinoid X receptor alpha [Source:MGI Symbol;Acc:MGI:98214])

HSP 1 Score: 226.098 bits (575), Expect = 1.725e-64
Identity = 123/335 (36.72%), Postives = 188/335 (56.12%), Query Frame = -1

Query:  952 NNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDR--------ISTRRSSFDDIPPNVILSISQLMQAEQRVAIQK-----PPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS---HILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETL 1905
               +C IC D+++GKHYG +SC+GCKGFF+R+VRK   YTC+ N++C +DK +RN+C+YCR +KC+ +GMKR AVQ ER R        + +  S+ +D+P   IL     ++ +    ++      P +P +       V ++C++   QLF LV WAK +P FS+L L DQ+ LL+A   E+LI     RS  +   D +LL   L + RNS+  H A + +    +L +L   +R++Q+D  E  CL+AIV F+P     S    V   R ++   L  +   K   +PGRF +LLL +P LR +    ++ + F K+ G   ID+ L E L
Sbjct:  108 TKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPND------PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAV--KDGILLATGLHVHRNSA--HSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 432

[Close]

BLAST of HNF4 vs. UniProt/SwissProt
Match: sp|Q91766|HNF4A_XENLA (Hepatocyte nuclear factor 4-alpha OS=Xenopus laevis OX=8355 GN=hnf4a PE=2 SV=2)

HSP 1 Score: 351.288 bits (900), Expect = 1.545e-109
Identity = 180/357 (50.42%), Postives = 250/357 (70.03%), Query Frame = -1

Query:  946 YKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1995
            ++  Q++ +   +   +V + +AS   G+  N LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  Q+  +    +N      + A + DVC+SMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RN  +     +A  ILD+L +P +ELQ+DD E+ACLKAI+FFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   28 FENMQVLSIGTDTSTSDVTSLSASNSIGI--NSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINVLIQAE--VLSQQITSSVGVLNTDIRGKKIACIIDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMF--KDILLLGNDRLIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPTKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

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BLAST of HNF4 vs. UniProt/SwissProt
Match: sp|Q14541|HNF4G_HUMAN (Hepatocyte nuclear factor 4-gamma OS=Homo sapiens OX=9606 GN=HNF4G PE=1 SV=3)

HSP 1 Score: 347.051 bits (889), Expect = 1.158e-108
Identity = 173/326 (53.07%), Postives = 236/326 (72.39%), Query Frame = -1

Query:  946 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQR---VAIQKPPNPQEY-MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1902
            N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+FD  +IP     SI+ L QAE R   +++  P +  +  + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGNN +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:    9 NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIP-----SINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 327

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BLAST of HNF4 vs. UniProt/SwissProt
Match: sp|P79926|HNF4B_XENLA (Hepatocyte nuclear factor 4-beta OS=Xenopus laevis OX=8355 GN=hnf4b PE=2 SV=1)

HSP 1 Score: 346.665 bits (888), Expect = 5.492e-108
Identity = 178/357 (49.86%), Postives = 236/357 (66.11%), Query Frame = -1

Query:  946 YKYYQIVFVSVSSQQHEVYASNASGPEGMEN--NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQE----YMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1995
            Y   +   + V     E+     + P  + N  N  C IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRIS RRSS++D   N  LSI+ L QAE  V    P +P       M + A + DVCESMK QL LLV WAK +P F +L L DQ++LL+AHAG  L+LGV +RS  L   D LLLGN+ I+  +  +   A +   ILD+L  PLRE+Q+DD E+ CLKAI+FFDP     S +  V+  R+Q+Q++L +++ND+Q+   GRF ++LL +P L+ +T  M+++V+F K+ G+A IDSLL E LLG
Sbjct:   14 YTMLEFDSIRVLPSNTEIITVETASPGLLNNGINSFCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHVYACRFSRQCIVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISMRRSSYED---NGSLSINVLTQAEAMVHQYSPVSPVHSSDISMKKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRS--LPYKDFLLLGNDFIMPMHCPELEIARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDPDCKGLSDQTKVKNMRFQVQVNLEDYINDRQFDSRGRFSDILLLLPPLQSITWQMIEQVQFAKLFGVARIDSLLQELLLG 365

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BLAST of HNF4 vs. UniProt/SwissProt
Match: sp|Q9WUU6|HNF4G_MOUSE (Hepatocyte nuclear factor 4-gamma OS=Mus musculus OX=10090 GN=Hnf4g PE=2 SV=2)

HSP 1 Score: 343.584 bits (880), Expect = 1.919e-107
Identity = 171/326 (52.45%), Postives = 233/326 (71.47%), Query Frame = -1

Query:  946 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEY----MNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1902
            N LC IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+++R C +DKDKRNQCRYCRL+KC   GMK+ AVQNERDRISTRRS+++  +IP     SI+ L QAE R      P+P       + + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ +I RNS +   + +A+ +LD+L  P +E+Q+DD E+ACLKAIVFFDP     S    ++  R+Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+ +ID+LL E LLG
Sbjct:    9 NCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTYEGSNIP-----SINTLAQAEVRSCQISVPSPSSSTDINIKKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMY--KDILLLGNHYVIHRNSCEVEVSRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQISLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLG 327

[Close]

BLAST of HNF4 vs. UniProt/SwissProt
Match: sp|P41235|HNF4A_HUMAN (Hepatocyte nuclear factor 4-alpha OS=Homo sapiens OX=9606 GN=HNF4A PE=1 SV=3)

HSP 1 Score: 345.51 bits (885), Expect = 3.162e-107
Identity = 177/344 (51.45%), Postives = 246/344 (71.51%), Query Frame = -1

Query:  937 ASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSD-KHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNP 1938
             +N + P  +  + LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QAE  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F +L L DQ++LL+AHAGE L+LG  +RS      DVLLLGN+ I+ R+  +    + ++  ILD+L +P +ELQ+DD E+A LKAI+FFDP    +S+ GK  ++R R Q+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG +P
Sbjct:   45 GTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALLQAE--VLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVF--KDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGK--IKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSP 379

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BLAST of HNF4 vs. TrEMBL
Match: H8YS99 (HNF4 OS=Schmidtea mediterranea OX=79327 GN=hnf4 PE=2 SV=1)

HSP 1 Score: 1219.14 bits (3153), Expect = 0.000e+0
Identity = 612/614 (99.67%), Postives = 613/614 (99.84%), Query Frame = -1

Query:  124 VSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGXXXXXXNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYXXXXXXXXXXXXXXXDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY 1965
            +SSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGNNNNNQNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYN DANHNCSNSSNSDDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY
Sbjct:   42 MSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGNNNNNQNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYNGDANHNCSNSSNSDDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY 655

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BLAST of HNF4 vs. TrEMBL
Match: A0A1S3J4P6 (hepatocyte nuclear factor 4-gamma isoform X2 OS=Lingula unguis OX=7574 GN=LOC106170072 PE=3 SV=1)

HSP 1 Score: 375.555 bits (963), Expect = 5.594e-115
Identity = 187/337 (55.49%), Postives = 242/337 (71.81%), Query Frame = -1

Query:  907 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE--QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPET 1902
            +Q C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC+++RNC +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRIS RR+S+D++  N  LS+S L+ AE   R       N      + A + DV ESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE LILGV RRS  L   DVLLLGN+ II R+SSD   + I+  ILD+L +PLRE+Q+DD+EFACLKAIVFFDP    +S+S K  ++  RYQ  ++L +++ND+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A+ID+LL E LLG    G  ++   T
Sbjct:  104 SQYCAICGDRATGKHYGAASCDGCKGFFRRSVRKNHVYTCRFSRNCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISVRRTSYDEVAQNGALSVSTLLNAEILSRQISSPLGNVDISQKKLASINDVVESMKQQLLVLVEWAKYIPSFCELPLDDQVSLLRAHAGEHLILGVARRSISL--KDVLLLGNDYIIPRHSSDLEVSRISGRILDELVVPLREVQIDDSEFACLKAIVFFDPDAKGLSDSAK--IKSMRYQAHINLEDYINDRQYDSRGRFGEILLMLPPLQSITWQMIEQIQFAKLFGMAKIDNLLQEMLLGGATEGAQTLATPT 436

[Close]

BLAST of HNF4 vs. TrEMBL
Match: A0A1S3J5Z2 (hepatocyte nuclear factor 4-gamma isoform X7 OS=Lingula unguis OX=7574 GN=LOC106170072 PE=3 SV=1)

HSP 1 Score: 371.703 bits (953), Expect = 1.222e-114
Identity = 187/347 (53.89%), Postives = 242/347 (69.74%), Query Frame = -1

Query:  907 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE--QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP-------------RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPET 1902
            +Q C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC+++RNC +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRIS RR+S+D++  N  LS+S L+ AE   R       N      + A + DV ESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE LILGV RRS  L   DVLLLGN+ II R+SSD   + I+  ILD+L +PLRE+Q+DD+EFACLKAIVFFDP              +S+S K  ++  RYQ  ++L +++ND+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A+ID+LL E LLG    G  ++   T
Sbjct:   13 SQYCAICGDRATGKHYGAASCDGCKGFFRRSVRKNHVYTCRFSRNCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISVRRTSYDEVAQNGALSVSTLLNAEILSRQISSPLGNVDISQKKLASINDVVESMKQQLLVLVEWAKYIPSFCELPLDDQVSLLRAHAGEHLILGVARRSISL--KDVLLLGNDYIIPRHSSDLEVSRISGRILDELVVPLREVQIDDSEFACLKAIVFFDPGMKFQHLGDTDAKGLSDSAK--IKSMRYQAHINLEDYINDRQYDSRGRFGEILLMLPPLQSITWQMIEQIQFAKLFGMAKIDNLLQEMLLGGATEGAQTLATPT 355

[Close]

BLAST of HNF4 vs. TrEMBL
Match: A0A1S3J492 (hepatocyte nuclear factor 4-gamma isoform X6 OS=Lingula unguis OX=7574 GN=LOC106170072 PE=3 SV=1)

HSP 1 Score: 371.703 bits (953), Expect = 2.517e-114
Identity = 187/347 (53.89%), Postives = 242/347 (69.74%), Query Frame = -1

Query:  907 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE--QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP-------------RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPET 1902
            +Q C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC+++RNC +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRIS RR+S+D++  N  LS+S L+ AE   R       N      + A + DV ESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE LILGV RRS  L   DVLLLGN+ II R+SSD   + I+  ILD+L +PLRE+Q+DD+EFACLKAIVFFDP              +S+S K  ++  RYQ  ++L +++ND+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A+ID+LL E LLG    G  ++   T
Sbjct:   34 SQYCAICGDRATGKHYGAASCDGCKGFFRRSVRKNHVYTCRFSRNCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISVRRTSYDEVAQNGALSVSTLLNAEILSRQISSPLGNVDISQKKLASINDVVESMKQQLLVLVEWAKYIPSFCELPLDDQVSLLRAHAGEHLILGVARRSISL--KDVLLLGNDYIIPRHSSDLEVSRISGRILDELVVPLREVQIDDSEFACLKAIVFFDPGMKFQHLGDTDAKGLSDSAK--IKSMRYQAHINLEDYINDRQYDSRGRFGEILLMLPPLQSITWQMIEQIQFAKLFGMAKIDNLLQEMLLGGATEGAQTLATPT 376

[Close]

BLAST of HNF4 vs. TrEMBL
Match: A0A1S3J4E8 (hepatocyte nuclear factor 4-gamma isoform X8 OS=Lingula unguis OX=7574 GN=LOC106170072 PE=3 SV=1)

HSP 1 Score: 369.777 bits (948), Expect = 4.358e-114
Identity = 186/340 (54.71%), Postives = 239/340 (70.29%), Query Frame = -1

Query:  928 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE--QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP-------------RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGV 1902
            +Q C IC D+ATGKHYGA SCDGCKGFFRRSVRK + YTC+++RNC +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRIS RR+S+D++  N  LS+S L+ AE   R       N      + A + DV ESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE LILGV RRS  L   DVLLLGN+ II R+SSD   + I+  ILD+L +PLRE+Q+DD+EFACLKAIVFFDP              +S+S K  ++  RYQ  ++L +++ND+QY   GRFGE+LL +P L+ +T  M+++++F K+ G+A+ID+LL E LLG    G 
Sbjct:  104 SQYCAICGDRATGKHYGAASCDGCKGFFRRSVRKNHVYTCRFSRNCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISVRRTSYDEVAQNGALSVSTLLNAEILSRQISSPLGNVDISQKKLASINDVVESMKQQLLVLVEWAKYIPSFCELPLDDQVSLLRAHAGEHLILGVARRSISL--KDVLLLGNDYIIPRHSSDLEVSRISGRILDELVVPLREVQIDDSEFACLKAIVFFDPGMKFQHLGDTDAKGLSDSAK--IKSMRYQAHINLEDYINDRQYDSRGRFGEILLMLPPLQSITWQMIEQIQFAKLFGMAKIDNLLQEMLLGGQVQGA 439

[Close]

BLAST of HNF4 vs. Ensembl Cavefish
Match: hnf4a (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:103043163])

HSP 1 Score: 352.058 bits (902), Expect = 8.689e-111
Identity = 183/361 (50.69%), Postives = 250/361 (69.25%), Query Frame = -1

Query:  946 SVVLYKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 2007
            + + ++  Q++ +S  S   E    NA+   G     LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++NR C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II+RN  +   + +   ILD+L +P +ELQ+DD E+ACLKAIVFFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   24 TTLEFENMQVLAMSTDSSPAESANMNAASHLGA--GSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VLSRQISSPGPILNGDIRTKKMATITDVCESMKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMLY--KDLLLLGNDHIIARNCPELEVSRVTVRILDELVLPFQELQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 375

[Close]

BLAST of HNF4 vs. Ensembl Cavefish
Match: hnf4a (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:103043163])

HSP 1 Score: 350.903 bits (899), Expect = 1.254e-110
Identity = 183/358 (51.12%), Postives = 249/358 (69.55%), Query Frame = -1

Query:  943 YKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGD 1995
            ++  Q++ +S  S   E    NA+   G     LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++NR C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II+RN  +   + +   ILD+L +P +ELQ+DD E+ACLKAIVFFDP     S    ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG+
Sbjct:   19 FENMQVLAMSTDSSPAESANMNAASHLGA--GSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VLSRQISSPGPILNGDIRTKKMATITDVCESMKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMLY--KDLLLLGNDHIIARNCPELEVSRVTVRILDELVLPFQELQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLGE 367

[Close]

BLAST of HNF4 vs. Ensembl Cavefish
Match: hnf4g (hepatocyte nuclear factor 4 gamma [Source:NCBI gene;Acc:103037173])

HSP 1 Score: 347.436 bits (890), Expect = 2.071e-109
Identity = 177/349 (50.72%), Postives = 243/349 (69.63%), Query Frame = -1

Query:  946 VSVSSQQHEVYASNAS---GPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRY-ADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1971
            + VS Q+ E   +  S   G  G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + Y+C++NR C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RRS  D  D+PP  +L+ ++ +   Q++ +  P  P +   +  A + DVCESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS  +   D+LLLGN  +I RN  +   + +A+ +LD+L  P +++Q+DD E+A LKAIVFFDP   S      ++  RYQ+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:    7 ILVSGQEEESMPTEPSISQGDNGVNSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFNRQCVVDKDKRNQCRFCRLHKCFRAGMKKEAVQNERDRISSRRSLQDSHDLPPITVLAQAESL--SQQINVASPAGPADISEKKSATIGDVCESMKQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRS--MPYKDILLLGNGCVIHRNCPEAEISRVANRVLDELVAPFQDIQIDDNEYAALKAIVFFDPDAKSLRDPSKIKNMRYQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLFGLAKIDNLLQEMLLG 349

[Close]

BLAST of HNF4 vs. Ensembl Cavefish
Match: hnf4g (hepatocyte nuclear factor 4 gamma [Source:NCBI gene;Acc:103037173])

HSP 1 Score: 345.125 bits (884), Expect = 3.531e-108
Identity = 174/334 (52.10%), Postives = 235/334 (70.36%), Query Frame = -1

Query:  946 SNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRY-ADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1935
            S + G  G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + Y+C++NR C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RRS  D  D+PP  +L  +Q     Q++ +  P  P +   +  A + DVCESMK QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS  +   D+LLLGN  +I RN  +   + +A+ +LD+L  P +++Q+DD E+A LKAIVFFDP   S      ++  RYQ+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:   50 SISQGDNGVNSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFNRQCVVDKDKRNQCRFCRLHKCFRAGMKKEAVQNERDRISSRRSLQDSHDLPPITVL--AQAESLSQQINVASPAGPADISEKKSATIGDVCESMKQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRS--MPYKDILLLGNGCVIHRNCPEAEISRVANRVLDELVAPFQDIQIDDNEYAALKAIVFFDPDAKSLRDPSKIKNMRYQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLFGLAKIDNLLQEMLLG 377

[Close]

BLAST of HNF4 vs. Ensembl Cavefish
Match: hnf4b (hepatic nuclear factor 4, beta [Source:ZFIN;Acc:ZDB-GENE-030131-2730])

HSP 1 Score: 293.123 bits (749), Expect = 3.342e-88
Identity = 162/327 (49.54%), Postives = 216/327 (66.06%), Query Frame = -1

Query:  940 NNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE----QRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDN 1905
               LC IC+DKATGKHYGA SCDGCKGFFRRSVRK + YTC+++R C +DKDKRNQCRYCRL+KC   GM++ AVQNERDRIS RR +         L+IS L++AE    Q +++  P        + A   DVCESMK QL LLV WAK +P F  L + D++ LL+AHA E LILG  RRS  L   D++LLGN+ II  +  ++  +++A+ +LD+L  PLREL ++D EFACLKAI+FF P        + VRR R+Q Q+ L    ++    + GRFGELLL +P L+ +   MV++++  ++ G A +DSLL E LLG+ 
Sbjct:   57 GGTLCSICADKATGKHYGANSCDGCKGFFRRSVRKNHAYTCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMRKEAVQNERDRISCRRENQG----IGTLTISVLLKAEASTHQYISL-VPLVSDMSSKKIARSGDVCESMKQQLLLLVEWAKRIPEFCDLPVDDRVCLLRAHAAEHLILGGARRS--LPYSDIILLGNDFIIPVSGPEREMSKLAARVLDELVRPLRELDINDTEFACLKAIIFFAPDCPGLESSQMVRRLRFQAQVLL----DEATCEQRGRFGELLLLLPPLQSMAWQMVEQLQLARLLGEASVDSLLQEMLLGEG 372

[Close]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Match: hnf4g (hepatocyte nuclear factor 4, gamma [Source:ZFIN;Acc:ZDB-GENE-060929-100])

HSP 1 Score: 305.449 bits (781), Expect = 2.312e-94
Identity = 168/347 (48.41%), Postives = 228/347 (65.71%), Query Frame = -1

Query:  946 SSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPP----NPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLL---GNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1962
            +SQ++     NA G   M     C IC D+ATGKHYGA SCDGCKGFFRRS+RK + Y+C+Y+R C +DKDKRNQCRY RLKKC   GMK+ AVQNERDRISTRR+S DD       SI+  +QAE       PP    +    + + A + D+CES+K QL +LV WAK LP F +L L DQ++LL+AHAGE L+LGV +RS  +   DVLLL   G+  I++R+  +     +A  +LD+L +P +ELQ+DD EFACLKA+VFFDP        E +R  R+Q Q+ L +++ D+QY   GRFG+LLL +P L+ +   M+++++  ++  +  +DSLL E LLG
Sbjct:   43 ASQRNVNVHHNAIGGGTMS---FCAICGDRATGKHYGASSCDGCKGFFRRSIRKNHMYSCRYSRQCVVDKDKRNQCRY-RLKKCFRAGMKKEAVQNERDRISTRRNSQDDATSP---SINTFVQAESLSRQFMPPMVGGSGDLSLKQVASIQDICESIKQQLLVLVEWAKYLPVFCELLLDDQVALLRAHAGEHLLLGVAKRS--MTYKDVLLLGAAGDGHILARSCPEADVGRVACRVLDELVVPFQELQIDDNEFACLKAVVFFDPDAKGLRDPERIRNVRFQAQLSLEDYVTDRQYESRGRFGQLLLLLPTLQSLAWQMIEQIQLARLLSVVRVDSLLQEMLLG 380

[Close]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Match: nr2f1b (nuclear receptor subfamily 2, group F, member 1b [Source:NCBI gene;Acc:393564])

HSP 1 Score: 136.346 bits (342), Expect = 2.791e-35
Identity = 101/333 (30.33%), Postives = 159/333 (47.75%), Query Frame = -1

Query:  940 RSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKR--AAVQNERDRISTRRSSFDDIP------------PNVILS------------------ISQLMQAEQRVAIQKPPNPQEYM-------NRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS-HILDDLFIPLRELQLDDAEFACLKAIVFFDP-RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDN 1815
            RSVR+   YTC+ NRNC +D+  RNQC+YCRLKKC+ VGM+R  A V+   D+    R S    P            PN  L                   IS L++AE        P P           N    + ++CE     LF  V WA+++P F  L ++DQ++LL+    E+ +L   + +  L     LL    L  S  S+D+  A +    I  +    L+ L +D AE++CLKAIV F       S    +   + + Q  L  ++  +  ++P RFG+LLL +P LR V+  +++++ F+++ G   I++L+ + LL  +
Sbjct:    1 RSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREGACVKVHADQ----RVSLVPFPAVQRGRLAPTQHPNPALQYALVNGDPLNGHSYLSGYISLLLRAE--------PYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVALLRLVWSELFVLNAAQCAMPLHVAP-LLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFSTDACGLSDAAHIENLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGS 320

[Close]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Match: ESR2 (estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468])

HSP 1 Score: 133.265 bits (334), Expect = 3.827e-34
Identity = 88/282 (31.21%), Postives = 142/282 (50.35%), Query Frame = -1

Query: 1183 ASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKR------AAVQNERDRISTRRS--------------SFDDIPPNVILSISQLMQAEQRVAIQKPP-------NPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLF---IPLRELQLDDAEFACLKAIVFFD 1938
            AS   GP      QLC +C D ++G HYG ++C+GCK FF+RSV+ KNN+ C    +C +DK +R +C+ CRL+KC   GM R       A  +   R++ R S              S      +++L I  L +  Q + ++  P       +P E +   + +    +    ++  +V+WAK +P F +L+L  +I LL+    E+LI G+I RS  +++ D L+  ++L+ +R  +D    E    I D +       REL L   E+ACLKA+V  +
Sbjct:    1 ASPVDGPA----TQLCSVCGDFSSGYHYGVWTCEGCKAFFKRSVQGKNNFVCPATNHCTIDKTRRRRCQACRLRKCYEAGMIRDVPLLATACSSRLTRLARRHSPACHGSLAAPYSTHSPSLPLQSLLLRIQLLPKHLQAILLEAEPPKLLCMRSPGEPLTEASMMTLFTDLATKEMVHIVSWAKKIPGFMELDLPVKIQLLENSWVEVLITGLIWRS--MEQQDTLVFASDLVFTR--ADGSRMEGTMEIFDQVLAIVTHFRELCLRMEEYACLKAMVLLN 274

[Close]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Match: ESR2 (estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468])

HSP 1 Score: 131.724 bits (330), Expect = 1.148e-33
Identity = 89/292 (30.48%), Postives = 139/292 (47.60%), Query Frame = -1

Query: 1183 NQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRI-------------------------------------STRRS---SFDDIPPNVILS----ISQLMQAE--QRVAIQKPPNP---QEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLF---IPLRELQLDDAEFACLKAIVFFD 1902
             QLC +C D ++G HYG ++C+GCK FF+RSV+ KNN+ C    +C +DK +R +C+ CRL+KC   GM R    + RDRI                                       RR    SF    P+  +     I  L++AE  + + ++ P  P      M  + D+         ++  +V+WAK +P F +L+L  +I LL+    E+LI G+I RS  +++ D L+  ++L+ +R  +D    E    I D +       REL L   E+ACLKA+V  +
Sbjct:    2 TQLCSVCGDFSSGYHYGVWTCEGCKAFFKRSVQGKNNFVCPATNHCTIDKTRRRRCQACRLRKCYEAGMIRDGCHS-RDRILLCMVIKSLKQLEKNASHGIRNTTSAQTPTGYRGFKSDARRGGIRSFGGAVPHAHVEGMGIIHILLEAEPPKLLCMRSPGEPLTEASMMTLFTDLAT------KEMVHIVSWAKKIPGFMELDLPVKIQLLENSWVEVLITGLIWRS--MEQQDTLVFASDLVFTR--ADGSRMEGTMEIFDQVLAIVTHFRELCLRMEEYACLKAMVLLN 282

[Close]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Match: thrb (thyroid hormone receptor beta [Source:NCBI gene;Acc:30607])

HSP 1 Score: 128.642 bits (322), Expect = 4.496e-32
Identity = 101/358 (28.21%), Postives = 165/358 (46.09%), Query Frame = -1

Query:  991 NASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRK--KNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTR--------RSSFDDIPPNVI---------LSISQLMQA--------------EQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFL---------LVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLD-EDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP-RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMT 1932
             A  P  ++ N+ C++C DKATG HY   +C+GCKGFFRR+++K    +Y C+Y  +C +D+  RNQC+ CR +KCI VGM    V ++  R++ R        R   D+   NVI           + QL+ A               +R  +     P+  ++   D  D  +      F          +V++AK LP F++L   DQI LLK    EI+ L   R + + D E D L L   + + +         + S  + DL   L    LDD E A L+A++     R      + V + +    + L +++N +++     + +LL+ + DLRL+      ++  MK+T
Sbjct:   27 GAYMPSYLDKNEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYACKYEGSCIIDRITRNQCQECRYQKCIAVGMASDLVLDDSKRLAKRRLIEENRQRRKQDEKRRNVIERPGPSDKEWELIQLVTAAHCTTNAQGSQWKEHRRFLVSNCLGPESVLSSL-DGDDKVDLQAFTHFTAIITPSITRVVDFAKKLPMFTELPCEDQIVLLKGCCMEIMSL---RAAVRYDPESDTLTLNGEVAVKKEQLKNGGLGLVSDAIFDLGRSLAAFSLDDTEVALLQAVLLMSTDRPGLVNVDKVEKLQDTYLLALEHYINHREHRLNHFWPKLLMKVTDLRLIGACHSSRILHMKVT 380

[Close]

BLAST of HNF4 vs. Ensembl Nematostella
Match: EDO46487 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ27])

HSP 1 Score: 321.627 bits (823), Expect = 1.018e-101
Identity = 159/323 (49.23%), Postives = 223/323 (69.04%), Query Frame = -1

Query:  946 LICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAE--QRVAIQKPPNPQEYMN-----RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESG-KEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1890
            LIC+D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C++ RNC ++KDKRNQCR+CRL+KC   GMK+ AVQNERD IS +            L+   L+ AE   R A   PP  +  +      + A+  D+CESM+ QL +LV WAK LPCF +L L DQ++LL+AHA E L+LGV RRS  L   D+LLLGN+L+I R + D    +IA+ ILD++ +P+R+L +DD E++CLKAIVFF+P     G  + ++  R++IQ  L ++++D QY   G+FGE+LL +P L+ +   MV++++F ++ G+A++DSLL E LLG
Sbjct:    2 LICADRATGKHYGASSCDGCKGFFRRSVRKNHVYSCRFQRNCVINKDKRNQCRFCRLRKCFRAGMKKEAVQNERDSISKKPKE----EKKYGLTTQSLLSAEILSRPA-SSPPGTKTLLKSICLEKEANYSDICESMRQQLLILVEWAKHLPCFCELPLDDQVALLRAHASEHLVLGVSRRSLNL--KDILLLGNDLVIPRQAGDTEVRKIATRILDEIVLPMRQLNIDDVEYSCLKAIVFFNPDAKGLGDSQKIKALRFEIQTTLEDYISDHQYECRGKFGEILLLLPTLQAIALQMVEQIQFARLFGVAKVDSLLQEMLLG 317

[Close]

BLAST of HNF4 vs. Ensembl Nematostella
Match: EDO37645 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF49])

HSP 1 Score: 181.415 bits (459), Expect = 2.879e-50
Identity = 115/343 (33.53%), Postives = 186/343 (54.23%), Query Frame = -1

Query:  937 PEGMENN-QL-CLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNER---DRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVP-------DVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASH--ILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNP 1920
            PE  E N Q+ C +C DK++GKHYG F+C+GCK FF+RSVR+   YTC+ +R+C +D+  RNQC+YCRLKKC+ VGM+R AVQ  R    +  T+ ++   I  +   +    +     + ++  P P     +  ++P       ++CE     LF  V WA+++P F  L ++DQ++LL+    E+ +L   +    L      LL    I S + S         +  I  +    LR L +D AEFACLKAIV F    S  +  +++   + + Q  L  +  ++  ++P RFG+LLL +P LR ++  +V+++ F+++ G   I++LL + LL   P
Sbjct:   17 PEDSEKNVQVECAVCGDKSSGKHYGVFTCEGCKSFFKRSVRRNLTYTCRASRDCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRIPAAQTPTQNAALPGINGDGSTNGHSYLSGFIALLLRAEPYPTTRFQQGLNMPCGIMGIENICELAARLLFSAVEWARNIPFFPDLAVTDQVALLRLVWSELFVLNAAQCPMPLQVAP--LLATAGIHSNHMSPDRMVSFMDNIRIFQEQVEKLRNLHVDAAEFACLKAIVLFTSDASGLTDPQYIESLQEKTQCALEEYTRNQYPNQPTRFGKLLLRLPSLRSISSSVVEQLFFVRLVGKTPIETLLRDMLLSGTP 357

[Close]

BLAST of HNF4 vs. Ensembl Nematostella
Match: EDO38323 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD90])

HSP 1 Score: 162.54 bits (410), Expect = 9.572e-44
Identity = 119/346 (34.39%), Postives = 173/346 (50.00%), Query Frame = -1

Query:  958 CLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNR---NCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERD-RISTRRS--------------SFDDIPPNVILSISQLMQAEQR-----VAIQ------KPPNPQEYMN---RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS-HILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSE 1893
            C +C D+++GKHYG ++CDGC GFF+RS+R+  +YTC+      NC +DK  RNQCR CRLKKC  V M + AVQ+ER  R ST R               S    P      I+ L+ AE R     +A+       KP   Q  M+    Y+    VCE+    LF+ V WA+++P F  L   DQ+ LL+    E+ +LG  + S  L E   +L  + + +     +K    +A+   L +     +   +D  EFACLKAIV F P        E +   + Q Q+ L  ++      +  RFG LLL +P LR V+ L ++++ F K  G   I+ LLS+
Sbjct:    8 CKVCGDRSSGKHYGIYACDGCSGFFKRSIRRNRSYTCRATNGKGNCPVDKIHRNQCRSCRLKKCFDVSMNKDAVQHERGPRSSTLRKQKMLKEAQERLELVSVAHAPQGPSGFINTLLAAEPRMDGCGMAVNDFDLEYKPIRLQSDMSVPMYYSSPESVCEAAAKLLFMSVKWARNIPSFMSLPFRDQVILLEEGWRELFLLGASQWSMPL-EIAPILAASGMHVDNTPPEKIVDVMATVRTLQEAVNKFKAFGVDSTEFACLKAIVLFKPAACGLKDPEQIETTQDQAQLMLGEYIRSTYPTQVARFGRLLLLLPALRRVSALAIEELFFKKTIGTVPIERLLSD 352

[Close]

BLAST of HNF4 vs. Ensembl Nematostella
Match: EDO32715 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUB6])

HSP 1 Score: 159.844 bits (403), Expect = 3.525e-43
Identity = 105/329 (31.91%), Postives = 163/329 (49.54%), Query Frame = -1

Query:  958 ICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQR---VAIQKPPN-------PQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS-HILDDLFIPLRELQLDDAEFACLKAIVFFDPRV--------SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSE 1887
            +C D+++GKHYG F+CDGC+GFF+RS+R+   Y C+    C +D  +RNQC+ CRLKKC  V M + AVQ+ER   S +      I P    + +  +  E R   V  Q+  +       P  Y     D   + ES    L++ V WA+++P F  L   DQ  LL+    E+ +L   + S  LD    LL    L + +  +D+  A +A   +L ++    + LQ+D  E+ACLKAIV F P +             + V R + Q Q  L  +   +   +  RFG+LLL +P L+ V+  M++ + F        I+ +L +
Sbjct:    3 VCGDRSSGKHYGVFTCDGCRGFFKRSIRRNLTYHCKELGKCVVDVARRNQCQACRLKKCFEVQMNKDAVQHERAPRSAQ------ILPRATSTTTIDLNKEDRPDGVPTQRSTDMCPGWTFPTGYQTAPQD--SIYESAVQLLYMSVTWARNIPTFLDLPFRDQAILLEEGWSELFVLSSAQFSLPLDMGP-LLSAAGLQVDKAPTDRIVAGMADIRLLQNIVTRFKRLQIDSTEYACLKAIVLFKPVLPFFPVNLRGLRAPQLVERLQDQAQSMLGEYCRSQYPDQQVRFGKLLLMLPSLKTVSPKMIEDLFFRGTLDNVPIERMLCD 322

[Close]

BLAST of HNF4 vs. Ensembl Nematostella
Match: EDO38322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD88])

HSP 1 Score: 159.073 bits (401), Expect = 1.014e-42
Identity = 118/332 (35.54%), Postives = 177/332 (53.31%), Query Frame = -1

Query:  952 LCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTR--RSSFDDIPPNVILS--ISQLMQAEQ-RVAIQKPPNPQE--YMNRYADVPDVC-------ESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS-HILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLM--NHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETL 1896
            LC +C D ++G+HYG ++CDGC GFF RSVR+   YTC+ N  C +DK +RNQC+ CR KKC+ V M R AVQ ER   STR  +   D+     + +  ++ L+ AE  R A+ +        Y+ +    P  C       ES    LF+ V WA+++P F  L   DQ+ LL+    E+ I+G I+ +  L E   LL    + +    ++K  A +A    L ++    R LQ+ +AEFACLKAIV F P + +        C YQ Q  +M  +++  +   +  RFG+LLL +P LRLV    ++++ F +  G   I+SLL +  
Sbjct:    8 LCKVCGDISSGRHYGVYTCDGCSGFFMRSVRRDMVYTCKGNGGCTVDKKRRNQCQACRFKKCLEVKMNRFAVQQERQPNSTRVMKPHLDEYGLKGLNNEFLASLIVAEPCRDAVYRTSQGLNLPYLQQDVASPLFCSSPDALFESAARLLFMSVKWARNIPSFVNLPFRDQVVLLEEGWRELFIMGAIQWNLPL-EVAPLLAAAGMHVDNTPAEKIVATMADIRKLQEIGSRFRALQVCEAEFACLKAIVLFKPDLRDLRDPQQVEC-YQDQAQIMLGDYIKRQFAGQQVRFGKLLLMLPSLRLVRNKTIEELFFRQTIGSVAIESLLCDMF 337

[Close]

BLAST of HNF4 vs. Ensembl Medaka
Match: hnf4a (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:101174427])

HSP 1 Score: 355.525 bits (911), Expect = 3.605e-112
Identity = 184/363 (50.69%), Postives = 253/363 (69.70%), Query Frame = -1

Query:  946 SVVLYKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 2007
            + + ++  Q++ +   S   E    NA+G   +    LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II RN  +     +A  ILD+L +P +ELQ+DD E+ACLKAIVFFDP    +S+ GK  ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   15 TTLEFENMQVLPLGTDSSPAESTNMNATG--HLAAGSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VMTRQITSPTPILNGDVRTKKIATITDVCESMKQQLLVLVEWAKYIPAFCDLALDDQVALLRAHAGEHLLLGAAKRSMLY--KDILLLGNDHIIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIVFFDPDAKGLSDLGK--IKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 366

[Close]

BLAST of HNF4 vs. Ensembl Medaka
Match: hnf4a (hepatocyte nuclear factor 4 alpha [Source:NCBI gene;Acc:101174427])

HSP 1 Score: 354.755 bits (909), Expect = 5.251e-112
Identity = 184/359 (51.25%), Postives = 251/359 (69.92%), Query Frame = -1

Query:  946 YKYYQIVFVSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMN------RYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1995
            ++  Q++ +   S   E    NA+G   +    LC IC D+ATGKHYGA SCDGCKGFFRRSVRK + Y+C+++R C +DKDKRNQCRYCRLKKC   GMK+ AVQNERDRISTRRSS++D   + + SI+ L+QA+  V  ++  +P   +N      + A + DVCESMK QL +LV WAK +P F  L L DQ++LL+AHAGE L+LG  +RS      D+LLLGN+ II RN  +     +A  ILD+L +P +ELQ+DD E+ACLKAIVFFDP    +S+ GK  ++R RYQ+Q+ L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ G+A+ID+LL E LLG
Sbjct:   19 FENMQVLPLGTDSSPAESTNMNATG--HLAAGSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCIVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYED---SSLPSINALIQAD--VMTRQITSPTPILNGDVRTKKIATITDVCESMKQQLLVLVEWAKYIPAFCDLALDDQVALLRAHAGEHLLLGAAKRSMLY--KDILLLGNDHIIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIVFFDPDAKGLSDLGK--IKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLG 366

[Close]

BLAST of HNF4 vs. Ensembl Medaka
Match: hnf4g (hepatocyte nuclear factor 4-gamma [Source:NCBI gene;Acc:101162560])

HSP 1 Score: 335.88 bits (860), Expect = 3.396e-105
Identity = 174/331 (52.57%), Postives = 234/331 (70.69%), Query Frame = -1

Query:  946 GPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLM--QAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1923
            G +G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + YTC+++R C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RRS  D  D+PP  IL+ ++ +  Q    VA+    +  E   + A V DVC+SM+ QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS +    D+LLLGN  II RNS +     +A+  LD+L +P +++Q+DD E+A LKAIVFFDP   S      ++  R Q+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:   21 GADGLSSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYTCRFSRQCIVDKDKRNQCRFCRLNKCFRAGMKKEAVQNERDRISSRRSIPDSQDLPPITILAQAESLSQQITTPVALT---DTSEL--KSASVADVCDSMRQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRSMRF--KDLLLLGNGCIIHRNSPEPEICRVANRALDELVVPFQDIQIDDNEYAALKAIVFFDPDAKSLRNPSKIKAMRLQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLCGLAKIDNLLHEMLLG 342

[Close]

BLAST of HNF4 vs. Ensembl Medaka
Match: hnf4g (hepatocyte nuclear factor 4-gamma [Source:NCBI gene;Acc:101162560])

HSP 1 Score: 336.265 bits (861), Expect = 5.429e-105
Identity = 174/331 (52.57%), Postives = 234/331 (70.69%), Query Frame = -1

Query:  946 GPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFD--DIPPNVILSISQLM--QAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRV-SESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLG 1923
            G +G+ +N  C IC DKATGKHYGA SCDGCKGFFRRS+RK + YTC+++R C +DKDKRNQCR+CRL KC   GMK+ AVQNERDRIS+RRS  D  D+PP  IL+ ++ +  Q    VA+    +  E   + A V DVC+SM+ QL +LV WAK +P F +L L DQ+SLL+AHAGE L+LGV +RS +    D+LLLGN  II RNS +     +A+  LD+L +P +++Q+DD E+A LKAIVFFDP   S      ++  R Q+QM L +++ND+QY   GRFGELLL +P L+ +T  M+++++F+K+ GLA+ID+LL E LLG
Sbjct:   53 GADGLSSN--CAICGDKATGKHYGASSCDGCKGFFRRSIRKSHVYTCRFSRQCIVDKDKRNQCRFCRLNKCFRAGMKKEAVQNERDRISSRRSIPDSQDLPPITILAQAESLSQQITTPVALT---DTSEL--KSASVADVCDSMRQQLLVLVEWAKYIPAFGELPLDDQVSLLRAHAGEHLLLGVAKRSMRF--KDLLLLGNGCIIHRNSPEPEICRVANRALDELVVPFQDIQIDDNEYAALKAIVFFDPDAKSLRNPSKIKAMRLQVQMSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQLQFIKLCGLAKIDNLLHEMLLG 374

[Close]

BLAST of HNF4 vs. Ensembl Medaka
Match: rxraa (retinoid X receptor alpha [Source:NCBI gene;Acc:100125504])

HSP 1 Score: 227.254 bits (578), Expect = 6.641e-65
Identity = 127/343 (37.03%), Postives = 193/343 (56.27%), Query Frame = -1

Query:  952 PEGME---NNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPP--NVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVP---------DVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIAS---HILDDLFIPLRELQLDDAEFACLKAIVFFDP---RVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETL 1920
            P GM       +C IC D+++GKHYG +SC+GCKGFF+R+VRK   YTC+ N++C +DK +RN+C+YCR +KC+ +GMKR AVQ ER R   +  +  +     N  + + ++++AE+ V     P  + Y+     VP         ++C++   QLF LV WAK +P FS L L DQ+ LL+A   E+LI     RS  +   D +LL   L + RNS+  H A + +    +L +L   +R++Q+D  E  CL+AIV F+P    +S  G+  V   R ++   L  +   K   +PGRF +LLL +P LR +    ++ + F K+ G   ID+ L E L
Sbjct:  112 PSGMALSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCIIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRAKEKNENEVESTSCVNEDMPVEKILEAEEAVE----PKTETYIETNLSVPSNSPNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSIAV--KDGILLATGLHVHRNSA--HSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPGE--VEALREKVYASLEAYCKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 444

[Close]

BLAST of HNF4 vs. Planmine SMEST
Match: SMESG000014588.1 (SMESG000014588.1)

HSP 1 Score: 1219.91 bits (3155), Expect = 0.000e+0
Identity = 613/614 (99.84%), Postives = 614/614 (100.00%), Query Frame = -1

Query:  124 VSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGXXXXXXNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYXXXXXXXXXXXXXXXDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY 1965
            +SSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGNNNNNQNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYNSDANHNCSNSSNSDDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY
Sbjct:   42 MSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGNNNNNQNDSMDIINSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPSSTSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVPSLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYNSDANHNCSNSSNSDDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIANRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY 655

HSP 2 Score: 55.0694 bits (131), Expect = 2.307e-7
Identity = 41/41 (100.00%), Postives = 41/41 (100.00%), Query Frame = -2

Query: 2346 MTSTQHPNLNPAFSYQLLTXXXXXXXXXXXXXSMQYPLESE 2468
            MTSTQHPNLNPAFSYQLLTSNSAPISISSNASSMQYPLESE
Sbjct:    1 MTSTQHPNLNPAFSYQLLTSNSAPISISSNASSMQYPLESE 41

[Close]

BLAST of HNF4 vs. Planmine SMEST
Match: SMESG000056421.1 (SMESG000056421.1)

HSP 1 Score: 173.326 bits (438), Expect = 1.062e-45
Identity = 111/383 (28.98%), Postives = 200/383 (52.22%), Query Frame = -1

Query:  949 SVSSQQHEVYASNASGPEG---------------MENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILS------ISQLMQAEQRVAIQKPPNPQEYMNR-YADVPDVCESMKNQLFL---------------LVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHI--LDDLFIPLRELQLDDAEFACLKAIVFFDPRVSE-SGKEFVRRCRYQIQMDLMNHMNDKQYHKPG---RFGELLLTIPDLRLVTQLMVKKVEFMKMTGLAEIDSLLSETLL 1968
            S+S++Q+E   +  +  EG               + NN  C++C DK++GKHYG ++C+GCK FF+RSVR+   Y+C+ N NC +D   RNQC+ CR +KC+ +GM++ AVQ  + RI    S +     +   S      I  +MQ +  ++ Q+      +MN  +++  ++C++   + +                ++ W+KS+P F  L+++DQI+LLK+   E+ +L     S  L     LL    L ++   ++K    +  HI  + D    L++ Q+D AEF+CLKA+V F+  +   S   +V   +  +Q  L  +   +++H P    RFG+LLL IP L+ +   +++++ F ++ G   + +L+ E ++
Sbjct:   72 SLSNKQYEEPTTTTTSAEGSSPSSPSNQDSEDNKLGNNIECVVCGDKSSGKHYGQYTCEGCKSFFKRSVRRNLTYSCRGNHNCPIDIHHRNQCQNCRFQKCLKMGMRKEAVQ--QGRIPQFSSHYGQYIASTYGSSYFNRFIGMMMQNDSMLSKQEKIG---FMNHLFSNHSNICDTTSEEKYFGIDSIYDIASKILHGVIQWSKSIPFFPDLSITDQITLLKSSWSELFLLTSAHSSTPLHLAP-LLASVGLQVNPVGAEK-VVILLDHIRLIQDQIEKLKKFQIDSAEFSCLKALVLFNSDIRGLSDPVYVEHIQETVQNALEEY---EKFHYPNQITRFGKLLLRIPQLKSINSSIIEELLFTRLIGNNSVTNLIKEYII 444

[Close]

BLAST of HNF4 vs. Planmine SMEST
Match: SMESG000019911.1 (SMESG000019911.1)

HSP 1 Score: 172.555 bits (436), Expect = 2.618e-45
Identity = 112/326 (34.36%), Postives = 170/326 (52.15%), Query Frame = -1

Query: 1006 VSVSSQQHEVYASNASGPEGMENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNV-ILSISQLMQAEQRVA-IQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDK-HFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPR-VSESGKEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVE 1971
            +S+ S Q   Y +N+       +  LC IC+D ATGKHYG  +C+GCKGFF+R++RK+ +YTC+    C + +  RN+C+ CR  KC+  GMK  AVQ ER     + SS   I  ++ I+    ++Q E     ++  P  +       +   +C  +  QLF LV WAKS+P FS L   DQ+ LL     EILI+    RS    E   L + N   +S + + K  F  +   IL +L + L+ +++D  E ACLK I+ FD   V+    E + + RY+I   L  +++ K   +P R  +LLL +  LR  T   V  ++
Sbjct:  151 LSIDSSQSS-YTNNSLAAAPSSHYDLCAICTDLATGKHYGVLACEGCKGFFKRTIRKELHYTCREKNMCPITERLRNRCQSCRFNKCLDQGMKIEAVQRERSVQQLQASSESKITDSIPIVEAENILQNEIAFYFVENSPGEELSTVEIDEAKLLCFVINKQLFNLVMWAKSVPGFSHLEKCDQMVLLNKCWVEILIVSFSFRSSVESEFGSLRMDNVHRLSLSVASKLGFGNLMIRILRELIMSLKYIKVDQMEIACLKTIILFDSNYVNLKNSELIAQFRYRIFDILKQYVSQKYPEQPFRIYKLLLKLTSLRSFTASFVTTMK 475

[Close]

BLAST of HNF4 vs. Planmine SMEST
Match: SMESG000078464.1 (SMESG000078464.1)

HSP 1 Score: 116.316 bits (290), Expect = 3.062e-26
Identity = 100/385 (25.97%), Postives = 170/385 (44.16%), Query Frame = -1

Query:  952 CLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRN----CKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDD-----------------------------------IPPNVILSISQLMQA----------------------EQRVAIQKPPNPQE-YMNRYADVPDVC------ESMKNQLFLLVNWAKSLPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESGKEFVRRCRYQIQMDLMNHMNDKQYHK--PGRFGELLLTIPDLRLVTQLMVKKVEFMK-MTGLAEIDSLLSETL 1893
            C IC D  +G HYG F C+ CKGFF+RSV+   +Y C   ++    C ++K  R +C  CR ++CI  GM+  AV+N+R R   R+S+ DD                                   IPP+  L  S+++ +                      E  VA+++  + +E  + + ++  D+       +  + +L  +V W++ LP F+ ++  DQI L++    ++LIL    RS   D  ++ L     I    + +    EI + IL  +   L+  +LD  EFACLK ++   P +     E   R   +    L+     + Y    P +F +L++ IP++R  +   VK++   K +T     +SLL E L
Sbjct:  307 CPICEDAISGYHYGIFCCESCKGFFKRSVQNHKDYVCHAQQSGGEPCVINKHTRKKCPSCRFQRCIDKGMRIEAVRNDRSR-GGRKSTSDDASQKTSNDAADSPNYLGFVRQLNSIQSTVSNSGNTIPPSSSLEYSKIVSSSNNGPLHRALSSRGRTSMMSVLENIVAVEETLSQEEDVLGQVSEDDDMAVYRVLLKLAEQRLHRMVRWSRLLPEFAAIDTDDQIMLVQNCWADLLILDCCYRSLG-DPREIHLTSGKCINLEAACELGAKEIVAFIL-QMTQKLKRFKLDIREFACLKVLLLMQPDLKNLKAEGRVRTFQETVSQLLLDYTTQNYENEIPNKFYDLIMCIPEIRSAS-FSVKEMLISKDLTPFLNHNSLLLELL 687

[Close]

BLAST of HNF4 vs. Planmine SMEST
Match: SMESG000023925.1 (SMESG000023925.1)

HSP 1 Score: 111.309 bits (277), Expect = 1.650e-25
Identity = 88/336 (26.19%), Postives = 161/336 (47.92%), Query Frame = -1

Query:  940 CLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCKMDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVILSISQL-MQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKSLPCFSQ--------LNLSDQISLLKAHAGEILILGVIRRSFQLDED----DVLLLGNNLIISRNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDP-RVSESGKEFVRRCRYQIQMDLMNH-MNDKQYHKPGRFGELLLTIPDLRLVTQLMVKKVEFMKMTGLA---EIDSLLSETLLGDN 1893
            C +C DK++G+HYG ++C+GCK FF+RSVR +++Y C  + +C +D  +RN C++CR +KC   GM++ AVQ  R  +ST  S        +I    +L MQ  + + I      Q  +  Y   P++ +   +   L+     +L C  Q        L++SDQ  L+K++   IL L   +   QL  +    + +   NN +I    +  H   I +H+       ++ L+ +  ++  L  ++ ++P     S    V      IQ  L++  + D          +LLL +P L +  Q +++++ F +M  L     I+ ++++ +L  N
Sbjct:   57 CKVCGDKSSGRHYGQYTCEGCKSFFKRSVRNQSSYQCYASGDCVIDIQRRNNCQFCRFQKCFASGMRKEAVQTGR-CLSTTGS--------IIYKTDKLAMQNSKNIPINSLDYNQSRLMDYLSAPEISQYGLSWSLLM----STLDCIGQDFRLKKSGLSMSDQFLLIKSNWHIILALIACQNQIQLPFNSWISEKMSYNNNGLI---HTIPHLNFIENHLRK-----IQNLKPNFKQYNWLFNVILYNPDTYGLSAPHLVGT----IQQTLLDSVITDLTKENVLIHSKLLLNVPSLVIFNQPLIEEILFREMINLGYFININQVINKWVLSYN 367

The following BLAST results are available for this feature:

BLAST of HNF4 vs. Ensembl Human
BLAST of HNF4 vs. Ensembl Celegans
BLAST of HNF4 vs. Ensembl Fly
BLAST of HNF4 vs. Ensembl Zebrafish
BLAST of HNF4 vs. Ensembl Xenopus
BLAST of HNF4 vs. Ensembl Mouse
BLAST of HNF4 vs. UniProt/SwissProt
BLAST of HNF4 vs. TrEMBL
BLAST of HNF4 vs. Ensembl Cavefish
BLAST of HNF4 vs. Ensembl Sea Lamprey
BLAST of HNF4 vs. Ensembl Yeast
BLAST of HNF4 vs. Ensembl Nematostella
BLAST of HNF4 vs. Ensembl Medaka
BLAST of HNF4 vs. Planmine SMEST

BLAST of HNF4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HNF4G	2.555e-110	51.74	hepatocyte nuclear factor 4 gamma [Source:HGNC Sym...	[more]
HNF4G	2.584e-110	51.74	hepatocyte nuclear factor 4 gamma [Source:HGNC Sym...	[more]
HNF4G	2.412e-109	53.07	hepatocyte nuclear factor 4 gamma [Source:HGNC Sym...	[more]
HNF4A	1.702e-108	51.45	hepatocyte nuclear factor 4 alpha [Source:HGNC Sym...	[more]
HNF4A	2.697e-108	51.45	hepatocyte nuclear factor 4 alpha [Source:HGNC Sym...	[more]

BLAST of HNF4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nhr-69	1.148e-65	37.50	Nuclear hormone receptor family member nhr-69 [So...	[more]
nhr-64	2.023e-54	36.67	Nuclear hormone receptor family member nhr-64 [So...	[more]
nhr-64	2.247e-54	36.67	Nuclear hormone receptor family member nhr-64 [So...	[more]
nhr-64	2.247e-54	36.67	Nuclear hormone receptor family member nhr-64 [So...	[more]
nhr-35	8.280e-54	32.73	Nuclear hormone receptor family member nhr-35 [So...	[more]

BLAST of HNF4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hnf4	6.502e-104	50.59	gene:FBgn0004914 transcript:FBtr0344784	[more]
Hnf4	1.586e-103	50.59	gene:FBgn0004914 transcript:FBtr0079747	[more]
Hnf4	1.586e-103	50.59	gene:FBgn0004914 transcript:FBtr0336633	[more]
Hnf4	1.718e-103	50.59	gene:FBgn0004914 transcript:FBtr0112846	[more]
Hnf4	2.359e-103	50.59	gene:FBgn0004914 transcript:FBtr0079748	[more]

BLAST of HNF4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hnf4a	9.728e-111	50.69	hepatocyte nuclear factor 4, alpha [Source:ZFIN;Ac...	[more]
hnf4a	9.728e-111	50.69	hepatocyte nuclear factor 4, alpha [Source:ZFIN;Ac...	[more]
hnf4a	9.728e-111	50.69	hepatocyte nuclear factor 4, alpha [Source:ZFIN;Ac...	[more]
hnf4g	1.086e-106	51.20	hepatocyte nuclear factor 4, gamma [Source:ZFIN;Ac...	[more]
hnf4g	1.396e-106	51.20	hepatocyte nuclear factor 4, gamma [Source:ZFIN;Ac...	[more]

BLAST of HNF4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HNF4G	4.793e-112	52.02	hepatocyte nuclear factor 4 gamma [Source:NCBI gen...	[more]
HNF4G	5.494e-112	51.73	hepatocyte nuclear factor 4 gamma [Source:NCBI gen...	[more]
HNF4G	9.157e-112	52.65	hepatocyte nuclear factor 4 gamma [Source:NCBI gen...	[more]
HNF4A	2.591e-111	50.42	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]
HNF4A	3.243e-111	50.42	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]

BLAST of HNF4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hnf4g	1.798e-108	52.45	hepatocyte nuclear factor 4, gamma [Source:MGI Sym...	[more]
Hnf4g	5.097e-108	52.45	hepatocyte nuclear factor 4, gamma [Source:MGI Sym...	[more]
Hnf4a	6.082e-108	53.82	hepatic nuclear factor 4, alpha [Source:MGI Symbol...	[more]
Hnf4a	9.105e-108	53.82	hepatic nuclear factor 4, alpha [Source:MGI Symbol...	[more]
Rxra	1.725e-64	36.72	retinoid X receptor alpha [Source:MGI Symbol;Acc:M...	[more]

BLAST of HNF4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q91766\|HNF4A_XENLA	1.545e-109	50.42	Hepatocyte nuclear factor 4-alpha OS=Xenopus laevi...	[more]
sp\|Q14541\|HNF4G_HUMAN	1.158e-108	53.07	Hepatocyte nuclear factor 4-gamma OS=Homo sapiens ...	[more]
sp\|P79926\|HNF4B_XENLA	5.492e-108	49.86	Hepatocyte nuclear factor 4-beta OS=Xenopus laevis...	[more]
sp\|Q9WUU6\|HNF4G_MOUSE	1.919e-107	52.45	Hepatocyte nuclear factor 4-gamma OS=Mus musculus ...	[more]
sp\|P41235\|HNF4A_HUMAN	3.162e-107	51.45	Hepatocyte nuclear factor 4-alpha OS=Homo sapiens ...	[more]

BLAST of HNF4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
H8YS99	0.000e+0	99.67	HNF4 OS=Schmidtea mediterranea OX=79327 GN=hnf4 PE...	[more]
A0A1S3J4P6	5.594e-115	55.49	hepatocyte nuclear factor 4-gamma isoform X2 OS=Li...	[more]
A0A1S3J5Z2	1.222e-114	53.89	hepatocyte nuclear factor 4-gamma isoform X7 OS=Li...	[more]
A0A1S3J492	2.517e-114	53.89	hepatocyte nuclear factor 4-gamma isoform X6 OS=Li...	[more]
A0A1S3J4E8	4.358e-114	54.71	hepatocyte nuclear factor 4-gamma isoform X8 OS=Li...	[more]

BLAST of HNF4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hnf4a	8.689e-111	50.69	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]
hnf4a	1.254e-110	51.12	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]
hnf4g	2.071e-109	50.72	hepatocyte nuclear factor 4 gamma [Source:NCBI gen...	[more]
hnf4g	3.531e-108	52.10	hepatocyte nuclear factor 4 gamma [Source:NCBI gen...	[more]
hnf4b	3.342e-88	49.54	hepatic nuclear factor 4, beta [Source:ZFIN;Acc:ZD...	[more]

BLAST of HNF4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hnf4g	2.312e-94	48.41	hepatocyte nuclear factor 4, gamma [Source:ZFIN;Ac...	[more]
nr2f1b	2.791e-35	30.33	nuclear receptor subfamily 2, group F, member 1b [...	[more]
ESR2	3.827e-34	31.21	estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3...	[more]
ESR2	1.148e-33	30.48	estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3...	[more]
thrb	4.496e-32	28.21	thyroid hormone receptor beta [Source:NCBI gene;Ac...	[more]

BLAST of HNF4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HNF4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO46487	1.018e-101	49.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37645	2.879e-50	33.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38323	9.572e-44	34.39	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32715	3.525e-43	31.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38322	1.014e-42	35.54	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of HNF4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hnf4a	3.605e-112	50.69	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]
hnf4a	5.251e-112	51.25	hepatocyte nuclear factor 4 alpha [Source:NCBI gen...	[more]
hnf4g	3.396e-105	52.57	hepatocyte nuclear factor 4-gamma [Source:NCBI gen...	[more]
hnf4g	5.429e-105	52.57	hepatocyte nuclear factor 4-gamma [Source:NCBI gen...	[more]
rxraa	6.641e-65	37.03	retinoid X receptor alpha [Source:NCBI gene;Acc:10...	[more]

BLAST of HNF4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000014588.1	2.307e-7	99.84	SMESG000014588.1	[more]
SMESG000056421.1	1.062e-45	28.98	SMESG000056421.1	[more]
SMESG000019911.1	2.618e-45	34.36	SMESG000019911.1	[more]
SMESG000078464.1	3.062e-26	25.97	SMESG000078464.1	[more]
SMESG000023925.1	1.650e-25	26.19	SMESG000023925.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30005748
GenBank	AFF18489.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30005748 ID=SMED30005748|Name=HNF4|organism=Schmidtea mediterranea sexual|type=transcript|length=3066bp
GAAGAATAACAAAGAAATTTATTGCCAAACTAAAATACCCGGCCTATTTC
ATCAAAAAAAAAACAATCAAAAACACAAATCGCTACGAAAACTTGTATAA
AAGATTCACATTAAAAGTCATCAATATTCCTCTTTTTTAAAGACTGATGA
TTCAGATTCTTGGATCCGAATGGGGTGATCTGTTAGGAAGTGAGCTGTTG
ACGAGATAGCTGAATAGTTTGATCTGGAATTGTGCTGTTGGTTCGCTTCC
GATGATCTGTTGGCGATTGATTGAATTTGGCAGTTTTCTATCGGCGAGTT
TGGAAGCGACTTGGTATAGGCCACAAGAAGCGACGGATCAACGACATTTT
GAGTGGAATTCACAGAAAGAGCTGGGTGGATTAGGTCATCTGAATTGGAA
GAATTTGAGCAGTTATGATTTGCGTCACTGTTATAGGCGTATTTTGACTG
GTTGATCATGGGGAACCCTTGATCAAGGTTGACCAAGAAATGGCTGGTAT
CCTGTGATAAATTGGAATGCTGATAAAGATTGATGGAATCATTGACGCAT
GAAAACAGAGAAGGAACGCCGACTCTTTCATTTTTCAGCATCATCCCATC
GCTGTTGATTATCATACCGAAGTTGCTATTGTCCTGGGAATTTTGCTGCA
TTATTTCAGTTCCTTGATTAACAAAAGCTCGATATATATTTCCTGAAGGC
ATCGACGTAGAACTTGGCAAATATGCACTCCATATTTTTGAGGCCGCTTC
AGGTGATATGTTTTGGTTGTTGATATTGAGTAGGACACTGTCTGGCATGA
AAGGGGGAATTCCGTAGCAGTCCTGGTAAGTATATTTCGGTGAGGAAATC
CTGTGGGAGTTAATTATATCCATGGAATCGTTTTGATTATTGTTATTGTT
CCCATCTGTTTCTGGATCTATGCTGAATACCCCTGGTGGATTGTCACCCA
ATAATGTTTCAGATAACAAGCTATCAATCTCGGCTAATCCTGTCATTTTC
ATGAACTCGACCTTCTTTACCATCAGCTGGGTGACCAATCTCAGATCAGG
AATTGTCAGCAGCAATTCCCCGAATCTACCCGGCTTGTGGTATTGCTTGT
CATTCATGTGGTTCATCAGGTCCATTTGTATTTGGTATCGGCATCGTCTC
ACGAACTCCTTGCCAGACTCGCTGACTCTCGGATCAAAAAATACGATCGC
TTTCAAACAAGCGAATTCTGCGTCATCCAATTGCAATTCTCGCAGCGGAA
TGAACAGGTCGTCAAGGATGTGACTGGCTATTTCAGCGAAATGTTTGTCA
CTGGAGTTCCTACTGATGATAAGATTGTTTCCCAATAATAGCACATCGTC
TTCGTCCAATTGAAACGACCGCCTTATTACTCCAAGAATTAGAATTTCTC
CCGCGTGTGCTTTTAAAAGGGAAATTTGATCGCTCAAGTTTAACTGTGAA
AAACAAGGCAAAGACTTTGCCCAATTCACTAGAAGAAATAACTGATTTTT
CATGGACTCGCAAACATCAGGCACATCGGCATATCTGTTCATGTATTCCT
GAGGATTCGGGGGCTTTTGTATTGCAACCCTTTGCTCGGCCTGCATCAAC
TGAGAAATGGAGAGAATGACATTCGGAGGAATATCATCAAACGACGATCT
TCGAGTACTGATCCTATCTCGTTCATTTTGAACCGCTGCTCGCTTCATTC
CTACAAGAATGCATTTCTTTAGCCGACAATAACGGCATTGGTTTCGTTTA
TCCTTGTCCATTTTACAATTCCGATTGTACTGGCAAGTGTAGTTATTCTT
CTTCCTCACTGACCTCCGAAAAAATCCTTTACAACCGTCACACGAGAAAG
CCCCATAATGTTTTCCTGTAGCTTTGTCACTGCAAATGAGACAGAGTTGA
TTGTTTTCCATTCCTTCTGGTCCCGACGCGTTAGACGCATAGACTTCATG
TTGTTGCGAGGACACTGAAACGAAAACTATTTGATAATATTTGTACAAAA
CAACTGACAGATGGTTTCGGAAAAGGTTCAATGTTCAGCCATAGTTCAGC
GAAAGGTCAAATTCCTGAACTACTATTTCAAGGTATAAATTTGAATATAT
TGGTTTTGCCTCGTGCTAACAAAGTCCAGAAATATAATAAGCAAAGTCTG
AATCGTGTACTTTGGATTTCTAGCCAGGGGCACACAATAACCTATATTTA
ATAGCAGTTCATTGCGTTCACTCGTTATTTCTCCGACTGAACTGCATTGC
AGGAGGATCCGCAACCATGGAGATTTCATAATTATTATCAAAATGATAAT
AATAATAATTATTATGAGGTATTGTAAAAGAAAACGTAACTCACTTTCAC
TTTCCAATGGATATTGCATCGAGGAAGCGTTGCTGGAAATGGAAATCGGA
GCTGAATTGCTAGTCAATAGTTGATAGGAGAATGCTGGATTGAGGTTCGG
ATGCTGGGTAGACGTCATATAGAATTGGCTCGACGGATTCGGTAAAATTA
TGGTGAAGTTTACAATCGAAGCTCAGATATAACGTATTATAATGAAGTAT
TATTAATAAACTGCAAGTAACGTGCGCGCATTCTGAAGTGGTTGATTGAG
AATAATCAGTTCTTATTCGACAAATTCAGATAAAAAAGGCACCACTCGAA
TTGTTCAGCTGCGTCATGTGAATGCCGGAACGTTGTGCGTTGGCTGTTGG
CAGATCAGCGCTCCGTGTTCACTGCAATCCGGATACACCAGACCACTTGA
AATCGTTGCGAATTCAGCGTGTCGAGTGCATTGTGCGAGATCAGTATCGG
TGTGTATGTGTGTCTGCCTGTGTGCGTGTGGATGTGTGTGCTTGTCGAGT
CGGTTGTGTGTTTATGAGTGTAACTGTGTCGATTTGGTCGAATGCAGTAG
CAGATAGCTGAAATGCGATTGTTCCTATTTTTCATTTAATATTGTTTTAT
GTTTTGTTTCTATTTTTATAATTTAATTTATCAGTTTTTGTTTAGATTAT
GCAATCATTGTTTAATTTATTTTTGTCAATTTAAAATTTATTATTAATTA
AATTATTATAATTATT

protein sequence of SMED30005748-orf-1

>SMED30005748-orf-1 ID=SMED30005748-orf-1|Name=SMED30005748-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=597bp
MENNQLCLICSDKATGKHYGAFSCDGCKGFFRRSVRKKNNYTCQYNRNCK
MDKDKRNQCRYCRLKKCILVGMKRAAVQNERDRISTRRSSFDDIPPNVIL
SISQLMQAEQRVAIQKPPNPQEYMNRYADVPDVCESMKNQLFLLVNWAKS
LPCFSQLNLSDQISLLKAHAGEILILGVIRRSFQLDEDDVLLLGNNLIIS
RNSSDKHFAEIASHILDDLFIPLRELQLDDAEFACLKAIVFFDPRVSESG
KEFVRRCRYQIQMDLMNHMNDKQYHKPGRFGELLLTIPDLRLVTQLMVKK
VEFMKMTGLAEIDSLLSETLLGDNPPGVFSIDPETDGNNNNNQNDSMDII
NSHRISSPKYTYQDCYGIPPFMPDSVLLNINNQNISPEAASKIWSAYLPS
STSMPSGNIYRAFVNQGTEIMQQNSQDNSNFGMIINSDGMMLKNERVGVP
SLFSCVNDSINLYQHSNLSQDTSHFLVNLDQGFPMINQSKYAYNSDANHN
CSNSSNSDDLIHPALSVNSTQNVVDPSLLVAYTKSLPNSPIENCQIQSIA
NRSSEANQQHNSRSNYSAISSTAHFLTDHPIRIQESESSVFKKEEY*

protein sequence of SMED30005748-orf-2

>SMED30005748-orf-2 ID=SMED30005748-orf-2|Name=SMED30005748-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=132bp
MTSTQHPNLNPAFSYQLLTSNSAPISISSNASSMQYPLESESELRFLLQY
LIIIIIIIILIIIMKSPWLRILLQCSSVGEITSERNELLLNIGYCVPLAR
NPKYTIQTLLIIFLDFVSTRQNQYIQIYTLK*

Aliases

The feature 'HNF4' has the following synonyms


Synonym
hnf-4

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000070	intestinal phagocyte
PLANA:0000120	progenitor cell
PLANA:0000429	neoblast
PLANA:0002075	pigment cell
PLANA:0003108	gastrodermal cell
PLANA:0003116	parenchymal cell
PLANA:0000058	embryonic digestive system
PLANA:0000049	digestive system
PLANA:0000039	gamma neoblast
PLANA:0000026	gut
PLANA:0000023	embryonic pharynx

Vocabulary: **INTERPRO**
Term	Definition
IPR035500	NHR-like_dom_sf
IPR001723	Nuclear_hrmn_rcpt
IPR001628	Znf_hrmn_rcpt
IPR000536	Nucl_hrmn_rcpt_lig-bd
IPR013088	Znf_NHR/GATA

Vocabulary: **cellular component**
Term	Definition
GO:0042025	host cell nucleus
GO:0005634	nucleus

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0003707	steroid hormone receptor activity
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway

Vocabulary: **Schmidtea mediterranea Developmental Stages**
Term	Definition
PLANA:0000008	Stage 8
PLANA:0000007	Stage 7
PLANA:0000006	Stage 6
PLANA:0000002	Stage 2
PLANA:0000005	Stage 5

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001723	Nuclear hormone receptor	PRINTS	PR00398	STRDHORMONER	coord: 68..78 score: 45.49 coord: 226..241 score: 47.14 coord: 136..157 score: 34.99 coord: 282..299 score: 29.8 coord: 157..173 score: 46.72
IPR001628	Zinc finger, nuclear hormone receptor-type	PRINTS	PR00047	STROIDFINGER	coord: 56..64 score: 62.02 coord: 7..23 score: 51.77 coord: 64..72 score: 60.32 coord: 23..38 score: 60.34
IPR001628	Zinc finger, nuclear hormone receptor-type	SMART	SM00399	c4gold	coord: 4..75 e-value: 5.3E-38 score: 142.3
IPR001628	Zinc finger, nuclear hormone receptor-type	PFAM	PF00105	zf-C4	coord: 5..74 e-value: 8.7E-30 score: 103.0
IPR001628	Zinc finger, nuclear hormone receptor-type	PROSITE	PS00031	NUCLEAR_REC_DBD_1	coord: 7..33
IPR001628	Zinc finger, nuclear hormone receptor-type	PROSITE	PS51030	NUCLEAR_REC_DBD_2	coord: 4..79 score: 21.136
IPR000536	Nuclear hormone receptor, ligand-binding domain	SMART	SM00430	holi	coord: 135..294 e-value: 3.6E-40 score: 149.5
IPR000536	Nuclear hormone receptor, ligand-binding domain	PFAM	PF00104	Hormone_recep	coord: 121..306 e-value: 6.8E-34 score: 117.3
IPR000536	Nuclear hormone receptor, ligand-binding domain	PROSITE	PS51843	NR_LBD	coord: 97..323 score: 50.946
IPR035500	Nuclear hormone receptor-like domain superfamily	GENE3D	G3DSA:1.10.565.10		coord: 98..323 e-value: 4.1E-69 score: 234.5
IPR035500	Nuclear hormone receptor-like domain superfamily	SUPERFAMILY	SSF48508	Nuclear receptor ligand-binding domain	coord: 73..320
IPR013088	Zinc finger, NHR/GATA-type	GENE3D	G3DSA:3.30.50.10		coord: 1..95 e-value: 8.1E-34 score: 117.9
None	No IPR available	PANTHER	PTHR24083:SF42	HEPATOCYTE NUCLEAR FACTOR 4-GAMMA	coord: 4..331
None	No IPR available	PANTHER	PTHR24083	NUCLEAR HORMONE RECEPTOR	coord: 4..331
None	No IPR available	CDD	cd06960	NR_DBD_HNF4A	coord: 7..82 e-value: 4.57587E-45 score: 151.958
None	No IPR available	SUPERFAMILY	SSF57716	Glucocorticoid receptor-like (DNA-binding domain)	coord: 4..87

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HNF4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 39

Owlery

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