Cullin 3

Overview


Name	Cullin 3
Smed ID	SMED30005732
Length (bp)	2561

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cullin 3 (SMED30005732) t-SNE clustered cells

Violin plots show distribution of expression levels for Cullin 3 (SMED30005732) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cullin 3 (SMED30005732) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cullin 3 (SMED30005732) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30005732

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30005732	h1SMcG0011658	Contig53851	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30005732	h1SMcG0011658	Contig53851	newmark_ests	PMID:29674431 Fincher et al., 2018
whole organism	SMED30005732	h1SMcG0011658	dd_Smed_v6_15476_0_1	dd_Smed_v6	PMID:29291974 Strand et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Cullin 3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 776.163 bits (2003), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++  MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

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BLAST of Cullin 3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 757.288 bits (1954), Expect = 0.000e+0
Identity = 421/797 (52.82%), Postives = 559/797 (70.14%), Query Frame = 2

Query:  170 LNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            ++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++  MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:    1 MDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744

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Query:  170 LNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            ++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++  MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:    1 MDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744

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BLAST of Cullin 3 vs. Ensembl Human
Match: CUL3 (cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553])

HSP 1 Score: 667.922 bits (1722), Expect = 0.000e+0
Identity = 364/715 (50.91%), Postives = 492/715 (68.81%), Query Frame = 2

Query:  413 QCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            Q W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++  MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   41 QAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702

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BLAST of Cullin 3 vs. Ensembl Human
Match: CUL4A (cullin 4A [Source:HGNC Symbol;Acc:HGNC:2554])

HSP 1 Score: 300.827 bits (769), Expect = 2.378e-89
Identity = 189/554 (34.12%), Postives = 298/554 (53.79%), Query Frame = 2

Query:  134 SNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQK--IKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S K+ IK F     L D Y    W  L +A+  +Q   +   + EELY+    +   K    LY   +    +H+Q   +  +     +  FL  +N CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  ++ +  ++      +L ++ +ER GE + +S +R    ML  L V     Y++ FE  FL+++   Y       L +      Y+N V +R+EEE  R   YLD ST+  ++  +E++L+ +H+  I+     GL+++L+E +  ++A MY+L SRV  G Q + Q  S +++  G A+V++  K     V +LL  +DK   ++      +  F N +   FE FIN     P E ++  +D KLR G K   D ++E   DK ++LFR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  +++G +DL V +LT G WPT +  + + L+ E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:   40 SKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQV-----YKDSFELKFLEETNCLY-AAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAIL---QKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDK-DMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYT-PMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF 582

HSP 2 Score: 115.546 bits (288), Expect = 1.009e-25
Identity = 77/177 (43.50%), Postives = 111/177 (62.71%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
             QVS +Q ++L+ FN+   ++F+E+   T I D +L R+L SL+  K   R+L+K PK K  +    D F  N  F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTL HNLL++E+  QLK  F   P  +K+RIESL++RDY+ R  D+   Y Y+A
Sbjct:  589 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVE--DGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759

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BLAST of Cullin 3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0
Identity = 337/823 (40.95%), Postives = 521/823 (63.30%), Query Frame = 2

Query:  119 SLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXX-XXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDN-------GLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKIL---MDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSK-STDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S +    KMRI+ F A++++QYV + WE LK+AI EIQ+KNNSGLSFEELYRNAYTMVL KHGE+LYNG K V+ +H+  ++ +++E++N+   L  + + W DH  AMVMIRDILMYMDR+YVAQ      VYN GL  +R  +LR   I + ++  LL ++  +RK   I    I++AC ML+ LG++S  +YE++FE+  L ++ ++YR   +++LS +N +  Y+ +VE  + +E+ RA  YLD  TE KI++V+++ ++++HI  IV M + G+ +ML  K+  ++  ++++  R+ +       GL+ + + +S +L E G  +V +E   K+P+ FV ELL L+D  S+LLT A  +   F+N+   DFE F+N N +SPE+++L++DD LR G K + D +++   D  ++LFRYLQ+KDVFE+Y+KQ+LAKRLL  KS SDD EK++++KL  ECG  FT KLE MF+D  +   L     DW  + +P     +D+ +RVLT G+WPT   N  + L +E+  A++ + ++Y  KH GR + +   LGN ++   FY                             P  + S + +G   S    + G+++   +               +  ILQV+T+QM+IL++FN  ++ +  +L+ E  IP+R+L R+L SL+L K SQRILV++ K K + D+  +D F +N++F SK  ++KVQ +T K     E RET+ +V+++RK  +EA IVRIMKARK L+HN L+AEVT+QL+ RFMP+P +IKQRIE+L+ER+YLAR + D + Y+Y+A
Sbjct:    5 SGNGGQQKMRIRPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREA-QPT-KMSIDISLRVLTAGVWPTVQCN-PVVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPP---------------------------PKASMSNEENGPGPS----SSGESMKERKP--------------EHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDAIDM--SDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

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Query:  119 SLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXX-XXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDN-------GLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKIL---MDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSK-STDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S +    KMRI+ F A++++QYV + WE LK+AI EIQ+KNNSGLSFEELYRNAYTMVL KHGE+LYNG K V+ +H+  ++ +++E++N+   L  + + W DH  AMVMIRDILMYMDR+YVAQ      VYN GL  +R  +LR   I + ++  LL ++  +RK   I    I++AC ML+ LG++S  +YE++FE+  L ++ ++YR   +++LS +N +  Y+ +VE  + +E+ RA  YLD  TE KI++V+++ ++++HI  IV M + G+ +ML  K+  ++  ++++  R+ +       GL+ + + +S +L E G  +V +E   K+P+ FV ELL L+D  S+LLT A  +   F+N+   DFE F+N N +SPE+++L++DD LR G K + D +++   D  ++LFRYLQ+KDVFE+Y+KQ+LAKRLL  KS SDD EK++++KL  ECG  FT KLE MF+D  +   L     DW  + +P     +D+ +RVLT G+WPT   N  + L +E+  A++ + ++Y  KH GR + +   LGN ++   FY                             P  + S + +G   S    + G+++   +               +  ILQV+T+QM+IL++FN  ++ +  +L+ E  IP+R+L R+L SL+L K SQRILV++ K K + D+  +D F +N++F SK  ++KVQ +T K     E RET+ +V+++RK  +EA IVRIMKARK L+HN L+AEVT+QL+ RFMP+P +IKQRIE+L+ER+YLAR + D + Y+Y+A
Sbjct:    5 SGNGGQQKMRIRPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREA-QPT-KMSIDISLRVLTAGVWPTVQCN-PVVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPP---------------------------PKASMSNEENGPGPS----SSGESMKERKP--------------EHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDAIDM--SDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

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Query:  119 SLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXX-XXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDN-------GLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKIL---MDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSK-STDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S +    KMRI+ F A++++QYV + WE LK+AI EIQ+KNNSGLSFEELYRNAYTMVL KHGE+LYNG K V+ +H+  ++ +++E++N+   L  + + W DH  AMVMIRDILMYMDR+YVAQ      VYN GL  +R  +LR   I + ++  LL ++  +RK   I    I++AC ML+ LG++S  +YE++FE+  L ++ ++YR   +++LS +N +  Y+ +VE  + +E+ RA  YLD  TE KI++V+++ ++++HI  IV M + G+ +ML  K+  ++  ++++  R+ +       GL+ + + +S +L E G  +V +E   K+P+ FV ELL L+D  S+LLT A  +   F+N+   DFE F+N N +SPE+++L++DD LR G K + D +++   D  ++LFRYLQ+KDVFE+Y+KQ+LAKRLL  KS SDD EK++++KL  ECG  FT KLE MF+D  +   L     DW  + +P     +D+ +RVLT G+WPT   N  + L +E+  A++ + ++Y  KH GR + +   LGN ++   FY                             P  + S + +G   S    + G+++   +               +  ILQV+T+QM+IL++FN  ++ +  +L+ E  IP+R+L R+L SL+L K SQRILV++ K K + D+  +D F +N++F SK  ++KVQ +T K     E RET+ +V+++RK  +EA IVRIMKARK L+HN L+AEVT+QL+ RFMP+P +IKQRIE+L+ER+YLAR + D + Y+Y+A
Sbjct:    5 SGNGGQQKMRIRPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREA-QPT-KMSIDISLRVLTAGVWPTVQCN-PVVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPP---------------------------PKASMSNEENGPGPS----SSGESMKERKP--------------EHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDAIDM--SDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

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BLAST of Cullin 3 vs. Ensembl Celegans
Match: cul-3 (Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391])

HSP 1 Score: 504.212 bits (1297), Expect = 1.123e-167
Identity = 301/767 (39.24%), Postives = 476/767 (62.06%), Query Frame = 2

Query:  287 MVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXX-XXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDN-------GLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKIL---MDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSK-STDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            MVL KHGE+LYNG K V+ +H+  ++ +++E++N+   L  + + W DH  AMVMIRDILMYMDR+YVAQ      VYN GL  +R  +LR   I + ++  LL ++  +RK   I    I++AC ML+ LG++S  +YE++FE+  L ++ ++YR   +++LS +N +  Y+ +VE  + +E+ RA  YLD  TE KI++V+++ ++++HI  IV M + G+ +ML  K+  ++  ++++  R+ +       GL+ + + +S +L E G  +V +E   K+P+ FV ELL L+D  S+LLT A  +   F+N+   DFE F+N N +SPE+++L++DD LR G K + D +++   D  ++LFRYLQ+KDVFE+Y+KQ+LAKRLL  KS SDD EK++++KL  ECG  FT KLE MF+D  +   L     DW  + +P     +D+ +RVLT G+WPT   N  + L +E+  A++ + ++Y  KH GR + +   LGN ++   FY                             P  + S + +G   S    + G+++   +               +  ILQV+T+QM+IL++FN  ++ +  +L+ E  IP+R+L R+L SL+L K SQRILV++ K K + D+  +D F +N++F SK  ++KVQ +T K     E RET+ +V+++RK  +EA IVRIMKARK L+HN L+AEVT+QL+ RFMP+P +IKQRIE+L+ER+YLAR + D + Y+Y+A
Sbjct:    1 MVLHKHGERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDLLKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREA-QPT-KMSIDISLRVLTAGVWPTVQCN-PVVLPQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPP---------------------------PKASMSNEENGPGPS----SSGESMKERKP--------------EHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDAIDM--SDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 717

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BLAST of Cullin 3 vs. Ensembl Celegans
Match: cul-2 (Cullin-2 [Source:UniProtKB/Swiss-Prot;Acc:Q17390])

HSP 1 Score: 197.593 bits (501), Expect = 1.195e-52
Identity = 201/832 (24.16%), Postives = 385/832 (46.27%), Query Frame = 2

Query:  191 KIWETLKKAIVEI-QKKNNSGLSFEELYRNAYTMVLQ---KHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNV-----YNTGLII--FRDIVLRNVEI-RESLQSNLLNMVAK--------ERKGEV--IAKSQIRDACQMLVQL-----------GV------NSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVV--VDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN------SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFP-IVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXX-XVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            K+W  L+ +I++I   +  + + +   + + Y + +       E+LYN  K  + EH+++ ++ +++   +  L   ++ W+  H   + I  +  Y+++ +V Q    ++     Y   L I   ++I    +EI +E L   +L  + K        +RKG    IA +++       V++           G       ++T  Y+E FEK  L  ++++Y   ++  L++ + S  Y+ +V   +E+E  RA+ YL  S+  K++ + ++ +I  H D++    H+  + ++  +++ ++ +MY+LL  +  GL +M +    +++++G   V  +     P  FV  +L + +K + + T    +   F + ++   +  +N         ++ E L+ + D  L++ TKG+ + D+EA  D  IV+FRY++DKD+F+++Y + LA RL+   S S D E+ MI+KL   CG  FTSKL  MF D                                           I LS+E+ + FD        KH   +  +QP++  V    +        +  P + + S++ TA ++     P I+ P       F +   H G         S  +  L       K+Y+ Q+  YQM  L+ F ++      ++ +E  +    L +++ ++    +   +L  + ++ + D L      +N S TSK  K ++Q   + +   + +E     V ++RKY +E  IVRIMK RK L HN L+ E+ +Q K RF P    IK+ IE L+E+ Y+ R+D + + Y+YLA
Sbjct:   30 KVWVQLRPSIIDIINLRPITNVQWHHKFSDVYDICVSIPTPLSERLYNEVKACIQEHVRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQKRCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFPHIA-NEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLTDLSCS-EYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKL----HAVCHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRLTGENVPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSKEPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQACGYEFTSKLSRMFTD-------------------------------------------IGLSQELSNNFD--------KHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQDVANFHLPRILQPVIQEFEKFYTG-KHNGRKLTWLFNMSQGDVRLTYLD---KQYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSGDYLLKTIRTI----LDVTLLTCDDQNLTADSL----VRLNMSMTSKRMKFRLQAPQVNKAVEKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRFSPDVPFIKKSIEDLIEKMYIQRTDQNDE-YQYLA 791

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BLAST of Cullin 3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302158)

HSP 1 Score: 747.273 bits (1928), Expect = 0.000e+0
Identity = 415/808 (51.36%), Postives = 564/808 (69.80%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRV-DNGLQMMSQCISSFLREQGRAVVVDE---SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFPAS++++YV  IW +LK AI EIQKKNNSGLSFE+LYRNAY MVL KHG +LY G + VV+EHL+ K++  VLE L++NFL  LNQ W DH T+MVMIRDILMYMDRVYV Q E  NVYN GLI+FRD V+R  EI+++L+  LL MV +ER GE I    I++AC ML+ LG+NS  +YEEDFEK FL QS  FY+ ES++FL+ENN  + YI +VE RI EES RA  YLD  TEP+IV+V+EEELI KH+  IV M +SG+ YM+   +  ++A  YKL SR+ + GL++++  +S++LREQGR +V +E   + +PI FV  LL L+D+    L  +  N  +F+N I++DFE+F+N N++SPEYLSLFIDDKL++G KGM + ++E++ DK +VLFR+L +KDVFERYYK HLAKRLL  KS SDD EK+MISKL  ECG  FTSKLEGMFKDM++S  +MD++ N +   N +  GV+L VR+LTTG WPTQ+   N ++    + AFD +  FYL+KH+GR + LQP +G   ++ +FY                  +      +D     APS  SSG                          G+ ++  +++ILQVSTYQM +L+ FN +   T+D++ +ET IP+R+L R+L SLS+ K +QR+LV+  K+K+ D+ PTD F +N++F SK +++K+Q +  K     ER+ET+ +VDE+RK+ IEA IVRIMKARK L+HNLL+++VT QLKSRF+P+P  IK+RIE L+ER+YL RS +D+K Y YLA
Sbjct:   13 KMRIRAFPASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGV-YIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYG---------------RKAVESEKDKD-----APSSSSSGC-------------------------GVPTT-TRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773

[Close]

BLAST of Cullin 3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302157)

HSP 1 Score: 747.273 bits (1928), Expect = 0.000e+0
Identity = 415/808 (51.36%), Postives = 564/808 (69.80%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRV-DNGLQMMSQCISSFLREQGRAVVVDE---SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFPAS++++YV  IW +LK AI EIQKKNNSGLSFE+LYRNAY MVL KHG +LY G + VV+EHL+ K++  VLE L++NFL  LNQ W DH T+MVMIRDILMYMDRVYV Q E  NVYN GLI+FRD V+R  EI+++L+  LL MV +ER GE I    I++AC ML+ LG+NS  +YEEDFEK FL QS  FY+ ES++FL+ENN  + YI +VE RI EES RA  YLD  TEP+IV+V+EEELI KH+  IV M +SG+ YM+   +  ++A  YKL SR+ + GL++++  +S++LREQGR +V +E   + +PI FV  LL L+D+    L  +  N  +F+N I++DFE+F+N N++SPEYLSLFIDDKL++G KGM + ++E++ DK +VLFR+L +KDVFERYYK HLAKRLL  KS SDD EK+MISKL  ECG  FTSKLEGMFKDM++S  +MD++ N +   N +  GV+L VR+LTTG WPTQ+   N ++    + AFD +  FYL+KH+GR + LQP +G   ++ +FY                  +      +D     APS  SSG                          G+ ++  +++ILQVSTYQM +L+ FN +   T+D++ +ET IP+R+L R+L SLS+ K +QR+LV+  K+K+ D+ PTD F +N++F SK +++K+Q +  K     ER+ET+ +VDE+RK+ IEA IVRIMKARK L+HNLL+++VT QLKSRF+P+P  IK+RIE L+ER+YL RS +D+K Y YLA
Sbjct:   13 KMRIRAFPASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGV-YIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYG---------------RKAVESEKDKD-----APSSSSSGC-------------------------GVPTT-TRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773

[Close]

BLAST of Cullin 3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302156)

HSP 1 Score: 747.273 bits (1928), Expect = 0.000e+0
Identity = 415/808 (51.36%), Postives = 564/808 (69.80%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRV-DNGLQMMSQCISSFLREQGRAVVVDE---SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFPAS++++YV  IW +LK AI EIQKKNNSGLSFE+LYRNAY MVL KHG +LY G + VV+EHL+ K++  VLE L++NFL  LNQ W DH T+MVMIRDILMYMDRVYV Q E  NVYN GLI+FRD V+R  EI+++L+  LL MV +ER GE I    I++AC ML+ LG+NS  +YEEDFEK FL QS  FY+ ES++FL+ENN  + YI +VE RI EES RA  YLD  TEP+IV+V+EEELI KH+  IV M +SG+ YM+   +  ++A  YKL SR+ + GL++++  +S++LREQGR +V +E   + +PI FV  LL L+D+    L  +  N  +F+N I++DFE+F+N N++SPEYLSLFIDDKL++G KGM + ++E++ DK +VLFR+L +KDVFERYYK HLAKRLL  KS SDD EK+MISKL  ECG  FTSKLEGMFKDM++S  +MD++ N +   N +  GV+L VR+LTTG WPTQ+   N ++    + AFD +  FYL+KH+GR + LQP +G   ++ +FY                  +      +D     APS  SSG                          G+ ++  +++ILQVSTYQM +L+ FN +   T+D++ +ET IP+R+L R+L SLS+ K +QR+LV+  K+K+ D+ PTD F +N++F SK +++K+Q +  K     ER+ET+ +VDE+RK+ IEA IVRIMKARK L+HNLL+++VT QLKSRF+P+P  IK+RIE L+ER+YL RS +D+K Y YLA
Sbjct:   13 KMRIRAFPASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGV-YIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYG---------------RKAVESEKDKD-----APSSSSSGC-------------------------GVPTT-TRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773

[Close]

BLAST of Cullin 3 vs. Ensembl Fly
Match: Cul3 (gene:FBgn0261268 transcript:FBtr0302159)

HSP 1 Score: 735.332 bits (1897), Expect = 0.000e+0
Identity = 413/804 (51.37%), Postives = 563/804 (70.02%), Query Frame = 2

Query:  152 KAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRV-DNGLQMMSQCISSFLREQGRAVVVDE---SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXX-XXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +AF AS++++YV  IW +LK AI EIQKKNNSGLSFE+LYRNAY MVL KHG +LY G + VV+EHL+ K++  VLE L++NFL  LNQ W DH T+MVMIRDILMYMDRVYV Q E  NVYN GLI+FRD V+R  EI+++L+  LL MV +ER GE I    I++AC ML+ LG+NS  +YEEDFEK FL QS  FY+ ES++FL+ENN  + YI +VE RI EES RA  YLD  TEP+IV+V+EEELI KH+  IV M +SG+ YM+   +  ++A  YKL SR+ + GL++++  +S++LREQGR +V +E   + +PI FV  LL L+D+    L  +  N  +F+N I++DFE+F+N N++SPEYLSLFIDDKL++G KGM + ++E++ DK +VLFR+L +KDVFERYYK HLAKRLL  KS SDD EK+MISKL  ECG  FTSKLEGMFKDM++S  +MD++ N +   N +  GV+L VR+LTTG WPTQ+   N ++    + AFD +  FYL+KH+GR + LQP +G   ++ +FY                  +      +D     APS  SSG                          G+ ++  +++ILQVSTYQM +L+ FN +   T+D++ +ET IP+R+L R+L SLS+ K +QR+LV+  K+K+ D+ PTD F +N++F SK +++K+Q +  K E+EPER+ET+ +VDE+RK+ IEA IVRIMKARK L+HNLL+++VT QLKSRF+P+P  IK+RIE L+ER+YL RS +D+K Y YLA
Sbjct:  178 RAFNASMDEKYVETIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGV-YIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFYG---------------RKAVESEKDKD-----APSSSSSGC-------------------------GVPTT-TRKHILQVSTYQMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934

[Close]

BLAST of Cullin 3 vs. Ensembl Fly
Match: Cul4 (gene:FBgn0033260 transcript:FBtr0301355)

HSP 1 Score: 309.301 bits (791), Expect = 2.838e-92
Identity = 197/556 (35.43%), Postives = 309/556 (55.58%), Query Frame = 2

Query:  140 KMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ---KIKEQVXXXXXXXXXXXX-XQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGV---DLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            K+ IK F    +L D Y    +  L++A++ IQ       S EELY+    M   K   +LY   K +  +H++   K+KE    +++   L    N  W      M+MIR I +YMDR YV Q     ++++ GL +FR    +N  +++     LL ++ KER+G  + +  ++   +ML  L      IY   FE+ FLD + + Y+ ES+  + E  +   Y+  V +R+ EE++R RHYLD ST+  ++  +E+EL+++H+  I+     GL+ +L + + +++  +Y LLSRV NG   +    + F++++GR +V+D  K   + V +LL  +DK   ++    +++  F N +   FE+FIN  +  P E ++ ++D KLR G KG  D ++E   DK +VLFR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECGG FTSKLEGMFKDM +S+ + +        +NN  V   DL V +LT G WPT +    +++  +  +    + KFYL KH+GR +  QP LGN  L   F
Sbjct:  101 KIVIKNFKDKPTLPDNYSKDTYVKLEEAVIAIQLSKPIKYSLEELYQAVVNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGLLTLIEKERQGSTVDRGLLKSLVRMLCDLQ-----IYTSSFEEKFLDATNQLYKAESQRKMQELEVP-EYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSIL---QKGLDSLLEDNRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIVIDPEKDK-SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRANKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDI-NIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYA-PTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQF 644

HSP 2 Score: 115.546 bits (288), Expect = 5.291e-26
Identity = 78/177 (44.07%), Postives = 116/177 (65.54%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            L VS +Q ++L+ FN K   +++E+L  T I D +L R+L SL+  +   R++ K PK +  ++L  D F  N  FT+K ++IK+  I +KET  E++ T+ RV ++R+Y I+A IVRIMK RKTLSHNLLI E+  QL   F   P  +K+RIESL++RDY+ R  D++  Y Y+A
Sbjct:  651 LLVSLFQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRA--RVITKTPKGR--EILDGDQFDFNNEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLT--FPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

[Close]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Match: cul3b (cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1])

HSP 1 Score: 772.311 bits (1993), Expect = 0.000e+0
Identity = 426/807 (52.79%), Postives = 566/807 (70.14%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   +     +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                                 P +   GS        GG  VTG              S  +++ILQVST+QM ILM FN + K TF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTS+ +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   14 KMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVIHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLTSTGVSLGGVDLIVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATFY--------------------------------GPIKKEDGS-----DMVGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSRLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766

[Close]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376])

HSP 1 Score: 769.615 bits (1986), Expect = 0.000e+0
Identity = 424/807 (52.54%), Postives = 568/807 (70.38%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ER+GEV+ +  IR+ACQML+ LG+    +YEEDFE  FLD S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL  RV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++ + ++ +  +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                                 P +   GS        GG  +TG              S  +++ILQVST+QM ILM FN + K+TF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   21 KMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLHSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDRGAIRNACQMLMVLGLEGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFGRVPNGLKTMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRHHLQTSQVSLCGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATFY--------------------------------GPIKKEDGSDVG----VGGALLTG--------------SNTRKHILQVSTFQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

[Close]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Match: cul3b (cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1])

HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0
Identity = 307/524 (58.59%), Postives = 391/524 (74.62%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAK 1696
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   +     +  GVDL VRVLTTG WPTQS     ++    + AF+ + +
Sbjct:   14 KMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVIHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLTSTGVSLGGVDLIVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRR 536

[Close]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 298.901 bits (764), Expect = 4.916e-88
Identity = 187/568 (32.92%), Postives = 313/568 (55.11%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXX--QCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S+ +  F  S    + K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K   KLY   +VV  +H++   +Q  E+  ++ L      +CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  ++ +++++      +L ++ +ER GE + +S         +   ++   IY++ FE+ FL+++   Y  E +  + E  +   Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+  I+     GLN +L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK   ++      +  F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  131 SAGSATFSNSKPGAAKKLVIKNFKEKPKLPENYTNETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISAKLYKQLRVVCEDHIKAQIDQFREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRFYIISDLKVQSKTIDGILLLIERERSGEAVDRSL-----LRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQRLMQEREVP-EYLHHVNKRLEEEADRVITYLDQSTQKSLIATVEKQLLGEHLTAIL---QKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWPT-YVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 687

HSP 2 Score: 90.1225 bits (222), Expect = 5.307e-18
Identity = 65/150 (43.33%), Postives = 97/150 (64.67%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMI 2458
            LQVS +Q ++L+ FN+  +++ +++   T I D +L R+L SL+  K   R+L K PKSK  D+   D F+ N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK     + Q++
Sbjct:  694 LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGK--ARVLTKIPKSK--DVEDGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKVSSQLL 839

[Close]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 298.901 bits (764), Expect = 6.284e-88
Identity = 187/568 (32.92%), Postives = 315/568 (55.46%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXX--XXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S+ +  F  S    + K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K   KLY   +VV  +H++   +Q  E+  ++ L    +++CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  ++ +++++      +L ++ +ER GE + +S         +   ++   IY++ FE+ FL+++   Y  E +  + E  +   Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+  I+     GLN +L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK   ++      +  F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  131 SAGSATFSNSKPGAAKKLVIKNFKEKPKLPENYTNETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISAKLYKQLRVVCEDHIKAQIDQFREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRFYIISDLKVQSKTIDGILLLIERERSGEAVDRSL-----LRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQRLMQEREVP-EYLHHVNKRLEEEADRVITYLDQSTQKSLIATVEKQLLGEHLTAIL---QKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWPT-YVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 687

HSP 2 Score: 116.316 bits (290), Expect = 4.218e-26
Identity = 79/177 (44.63%), Postives = 116/177 (65.54%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  +++ +++   T I D +L R+L SL+  K   R+L K PKSK  D+   D F+ N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y Y+A
Sbjct:  694 LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGKA--RVLTKIPKSK--DVEDGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 864

[Close]

BLAST of Cullin 3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 775.393 bits (2001), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

[Close]

BLAST of Cullin 3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 757.288 bits (1954), Expect = 0.000e+0
Identity = 421/798 (52.76%), Postives = 560/798 (70.18%), Query Frame = 2

Query:  167 SLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   26 TMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770

[Close]

BLAST of Cullin 3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 421/798 (52.76%), Postives = 560/798 (70.18%), Query Frame = 2

Query:  167 SLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   26 TMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 770

[Close]

BLAST of Cullin 3 vs. Ensembl Xenopus
Match: cul3 (cullin 3 [Source:NCBI gene;Acc:548729])

HSP 1 Score: 666.381 bits (1718), Expect = 0.000e+0
Identity = 364/715 (50.91%), Postives = 492/715 (68.81%), Query Frame = 2

Query:  413 QCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            Q W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   41 QAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702

[Close]

BLAST of Cullin 3 vs. Ensembl Xenopus
Match: cul4a (cullin 4A [Source:NCBI gene;Acc:548647])

HSP 1 Score: 296.204 bits (757), Expect = 3.268e-88
Identity = 191/558 (34.23%), Postives = 298/558 (53.41%), Query Frame = 2

Query:  116 ASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
             S  S S K+ IK F     L D Y    W+ L++A+  I+   +   + EELY+    +   K    LY   + V  EH+   K Q+   L    +N   +CWKDH   M+MIR I +++DR YV Q     ++++ GL +FR  V+ +  ++      +L ++ +ER GE + +S +R    ML  L V     Y+E FE  FL+++   Y  E +  + E  +   Y++ V +R+EEE  R   YLD  T   ++  +E++L+ +H+  I+     GL  ML+E +   +  MY+L SRV  G  ++ Q    +++  G  +V++  K     V ELL  +D    ++      +  F N +   FE FIN  +  P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  ++ G +DL V +LT G WPT +  +++ L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:   28 TSKPSASKKLIIKNFKDKPKLPDSYTQDTWQKLQEAVNAIESSTSIKYNLEELYQAVENLCSYKVSHTLYKQLRQVCEEHM---KAQIHHFLFLKKVN---RCWKDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRCHVVSDRMVQIKTIDGILKLIEQERSGEAVDRSLLRSLLGMLSDLQV-----YKESFETKFLEETNCLYAAEGQRLMQEREVP-EYLHHVNRRLEEEVDRVITYLDHGTHKPLIACVEKQLLGEHLTAILQ---KGLKNMLDENRDPELTLMYQLFSRVKGGQIILLQHWGEYIKNFGSGLVINPEKDK-DMVQELLDFKDNVDHIIDVCFQKNEKFVNTMKESFETFINRRANKPAELIAKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQHMQNHSDPGNIDLTVNILTMGYWPTYT-PVDVHLPAEMVKLQEIFKTFYLGKHSGRRLQWQSTLGHAVLKADF 568

HSP 2 Score: 52.373 bits (124), Expect = 3.416e-6
Identity = 36/85 (42.35%), Postives = 51/85 (60.00%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKV 2263
            LQVS +Q ++L+ FNK  ++ F+E+   T I D +L R+L SL+  K   R+L K PKSK  D+   D F  N  F  K Y+IK+
Sbjct:  575 LQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGK--ARVLNKSPKSK--DVEDGDRFCFNADFKHKLYRIKI 655

[Close]

BLAST of Cullin 3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360])

HSP 1 Score: 776.933 bits (2005), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

[Close]

BLAST of Cullin 3 vs. Ensembl Mouse
Match: Cul3 (cullin 3 [Source:MGI Symbol;Acc:MGI:1347360])

HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0
Identity = 364/715 (50.91%), Postives = 492/715 (68.81%), Query Frame = 2

Query:  413 QCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            Q W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   41 QAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 702

[Close]

BLAST of Cullin 3 vs. Ensembl Mouse
Match: Cul4a (cullin 4A [Source:MGI Symbol;Acc:MGI:1914487])

HSP 1 Score: 286.189 bits (731), Expect = 4.536e-84
Identity = 188/557 (33.75%), Postives = 297/557 (53.32%), Query Frame = 2

Query:  125 SSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQK--IKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            +  S K+ IK F     L D Y    W  L +A+  IQ   +   + EELY+    +   K    LY   + V  +H+Q   +  +     +  FL  +N CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR+ ++ +  ++      +L ++ +ER GE + +S +R    ML  L V     Y++ FE  FL+++   Y       L ++     Y+N V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+  I+     GL ++L+E +  ++  MY+L SRV  G   + Q  S +++  G  +V++  K     V +LL  +DK   ++      +  F N +   FE FIN     P E ++  +D KLR G K   D ++E + DK ++LFR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  +  G +DL V +LT G WPT +  + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:   37 TGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDLQV-----YKDSFELKFLEETNCLY-AAEGQRLMQDREVPEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLEHLLDENRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDK-DMVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWPTYT-PMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADF 582

HSP 2 Score: 115.161 bits (287), Expect = 8.170e-26
Identity = 77/177 (43.50%), Postives = 110/177 (62.15%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
             QVS +Q ++L+ FN+   ++F+E+   T I D +L R+L SL+  K   R+L+K PK K  +    D F  N  F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTL HNLL++E+  QLK  F   P  +K+RIESL++RDY+ R  D    Y Y+A
Sbjct:  589 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKA--RVLIKSPKGKEVE--DGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

[Close]

BLAST of Cullin 3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834])

HSP 1 Score: 288.115 bits (736), Expect = 1.212e-83
Identity = 183/568 (32.22%), Postives = 310/568 (54.58%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXX--XXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S+    F  S   ++ K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K    LY   + +  +H++    Q  E+  ++ L    +++CW++H   M+MIR I +++DR YV Q     ++++ GL +FR  ++ + +++      +L ++ +ER GE I +S         +   ++   IY++ FE+ FL ++   Y  E +  + E  +   Y++ V +R+EEE+ R   YLD +T+  ++  +E++L+ +H+  I+     GLN +L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK   ++      +  F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  163 STAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSL-----LRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVP-EYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAIL---QKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPT-YVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 719

HSP 2 Score: 117.472 bits (293), Expect = 1.989e-26
Identity = 79/177 (44.63%), Postives = 114/177 (64.41%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  +++ +E+   T I D +L R+L SL+  K   R+L K PK K  D+   D F  N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y Y+A
Sbjct:  726 LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGK--DIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 896

[Close]

BLAST of Cullin 3 vs. Ensembl Mouse
Match: Cul4b (cullin 4B [Source:MGI Symbol;Acc:MGI:1919834])

HSP 1 Score: 287.345 bits (734), Expect = 5.770e-83
Identity = 182/568 (32.04%), Postives = 307/568 (54.05%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXX--XXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S+    F  S   ++ K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K    LY   + +  +H++    Q  E+  ++ L    +++CW++H   M+MIR I +++DR YV Q     ++++ GL +FR  ++ + +++      +L ++ +ER GE I +S         +   ++   IY++ FE+ FL ++   Y       L +      Y++ V +R+EEE+ R   YLD +T+  ++  +E++L+ +H+  I+     GLN +L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK   ++      +  F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  237 STAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSL-----LRSLLSMLSDLQIYQDSFEQQFLQETNRLY-AAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAIL---QKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPT-YVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 793

HSP 2 Score: 117.857 bits (294), Expect = 1.831e-26
Identity = 79/177 (44.63%), Postives = 114/177 (64.41%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  +++ +E+   T I D +L R+L SL+  K   R+L K PK K  D+   D F  N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y Y+A
Sbjct:  800 LQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKA--RVLAKNPKGK--DIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970

[Close]

BLAST of Cullin 3 vs. UniProt/SwissProt
Match: sp|B5DF89|CUL3_RAT (Cullin-3 OS=Rattus norvegicus OX=10116 GN=Cul3 PE=1 SV=2)

HSP 1 Score: 778.474 bits (2009), Expect = 0.000e+0
Identity = 430/812 (52.96%), Postives = 570/812 (70.20%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

[Close]

BLAST of Cullin 3 vs. UniProt/SwissProt
Match: sp|Q9JLV5|CUL3_MOUSE (Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=1)

HSP 1 Score: 776.933 bits (2005), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

[Close]

BLAST of Cullin 3 vs. UniProt/SwissProt
Match: sp|Q13618|CUL3_HUMAN (Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2)

HSP 1 Score: 776.163 bits (2003), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++  MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

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BLAST of Cullin 3 vs. UniProt/SwissProt
Match: sp|Q6GPF3|CUL3B_XENLA (Cullin-3-B OS=Xenopus laevis OX=8355 GN=cul3b PE=1 SV=1)

HSP 1 Score: 775.778 bits (2002), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGAVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

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BLAST of Cullin 3 vs. UniProt/SwissProt
Match: sp|A4IHP4|CUL3_XENTR (Cullin-3 OS=Xenopus tropicalis OX=8364 GN=cul3 PE=2 SV=1)

HSP 1 Score: 775.393 bits (2001), Expect = 0.000e+0
Identity = 429/812 (52.83%), Postives = 569/812 (70.07%), Query Frame = 2

Query:  125 SSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            S    KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN + KYTF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QLK+RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   10 SRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

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BLAST of Cullin 3 vs. TrEMBL
Match: A0A183SVC2 (Cullin-3 OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS8170 PE=3 SV=1)

HSP 1 Score: 905.59 bits (2339), Expect = 0.000e+0
Identity = 494/820 (60.24%), Postives = 623/820 (75.98%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS-PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNS--IKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFG-SQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +   R+ EAS   +S+KMRIKAFP S++++++ + WE LK+A++EIQKKNNSGLSFEELYRNAYT+VLQK G+ LY GT+ VV EH+ +I+E V+E+LNN FL++LN  WKDH TAM MIRDILMYMDR+YV +    NVY  G+  F   VLR   IRE+LQ  LL+MV +ER G+ I++ QIRDACQM VQLGV S  +YEEDFE+ FL Q++EFYR ESE+FL+E+  + MY+ +VEQRIEEE KRA  YLD STEPK+V VLEEELIS+H+  IVNM +SGL ++L   +   IA+MY +LSRV  G + MSQCIS+FLRE+G+ +V +   S P  ++ +LL LRD+ + LLT +L N  +FRNQINADFEYFIN N +S E+LSLFID+KLRRGTKGM D DV+AVFDKC VLFRYLQ+KD+FERYYKQHLAKRLL  KSQSDDQEKSMISKL+ ECGGVFTSKLEGMFKDMA+SK LM+++L S  + P+    +DLYVRVLTTGLWPTQS++  +SL EE  +AF+ Y+ FYLSKH+GR I+L  NLG+ ELS LF+    NS       +                 VAP     GS G S+I      A + +RA++            ++YILQVSTYQMVILM FN+++++TF ELL +T IP+RDL RSL++LSLS+ +QRIL KEPKSK  +  PTDVFT+N++FTS+HYK+KVQNI ++E+EPER+ET+TR+DENR+YVIEATIVRIMK RKTL HN L+AEV EQLKSRF PTP  IKQRIE+L+ER+++ARSD D+K Y+YLA
Sbjct:    3 TGGARRVEAS---SSSKMRIKAFPTSMDERHINQTWEQLKRAMLEIQKKNNSGLSFEELYRNAYTLVLQKKGDLLYTGTERVVQEHMLRIREAVIEHLNNQFLSFLNTSWKDHQTAMTMIRDILMYMDRIYVPRERLDNVYKMGMTFFCQYVLRYPIIRENLQKTLLDMVKRERLGDAISRPQIRDACQMFVQLGVGSLAVYEEDFEQAFLRQTREFYRAESEAFLAEHTSATMYVQKVEQRIEEEMKRAYQYLDSSTEPKVVAVLEEELISRHLQTIVNMENSGLVFLLTHDRFDEIANMYNVLSRVPEGPKAMSQCISTFLRERGQNIVRESGSSNPQQYIQDLLQLRDRCNVLLT-SLGNKQIFRNQINADFEYFINLNPKSTEFLSLFIDEKLRRGTKGMADQDVDAVFDKCTVLFRYLQEKDIFERYYKQHLAKRLLLSKSQSDDQEKSMISKLMAECGGVFTSKLEGMFKDMAVSKTLMEEFLQSTPVTPS----LDLYVRVLTTGLWPTQSVSPRVSLPEEAMAAFNVYSTFYLSKHSGRKISLHTNLGHAELSALFFG---NSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQA-SASRANA------------RKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 796

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BLAST of Cullin 3 vs. TrEMBL
Match: A0A0X3PL62 (Cullin-3 (Fragment) OS=Schistocephalus solidus OX=70667 GN=CUL3 PE=3 SV=1)

HSP 1 Score: 905.205 bits (2338), Expect = 0.000e+0
Identity = 494/820 (60.24%), Postives = 623/820 (75.98%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS-PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNS--IKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFG-SQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +   R+ EAS   +S+KMRIKAFP S++++++ + WE LK+A++EIQKKNNSGLSFEELYRNAYT+VLQK G+ LY GT+ VV EH+ +I+E V+E+LNN FL++LN  WKDH TAM MIRDILMYMDR+YV +    NVY  G+  F   VLR   IRE+LQ  LL+MV +ER G+ I++ QIRDACQM VQLGV S  +YEEDFE+ FL Q++EFYR ESE+FL+E+  + MY+ +VEQRIEEE KRA  YLD STEPK+V VLEEELIS+H+  IVNM +SGL ++L   +   IA+MY +LSRV  G + MSQCIS+FLRE+G+ +V +   S P  ++ +LL LRD+ + LLT +L N  +FRNQINADFEYFIN N +S E+LSLFID+KLRRGTKGM D DV+AVFDKC VLFRYLQ+KD+FERYYKQHLAKRLL  KSQSDDQEKSMISKL+ ECGGVFTSKLEGMFKDMA+SK LM+++L S  + P+    +DLYVRVLTTGLWPTQS++  +SL EE  +AF+ Y+ FYLSKH+GR I+L  NLG+ ELS LF+    NS       +                 VAP     GS G S+I      A + +RA++            ++YILQVSTYQMVILM FN+++++TF ELL +T IP+RDL RSL++LSLS+ +QRIL KEPKSK  +  PTDVFT+N++FTS+HYK+KVQNI ++E+EPER+ET+TR+DENR+YVIEATIVRIMK RKTL HN L+AEV EQLKSRF PTP  IKQRIE+L+ER+++ARSD D+K Y+YLA
Sbjct:    8 TGGARRVEAS---SSSKMRIKAFPTSMDERHINQTWEQLKRAMLEIQKKNNSGLSFEELYRNAYTLVLQKKGDLLYTGTERVVQEHMLRIREAVIEHLNNQFLSFLNTSWKDHQTAMTMIRDILMYMDRIYVPRERLDNVYKMGMTFFCQYVLRYPIIRENLQKTLLDMVKRERLGDAISRPQIRDACQMFVQLGVGSLAVYEEDFEQAFLRQTREFYRAESEAFLAEHTSATMYVQKVEQRIEEEMKRAYQYLDSSTEPKVVAVLEEELISRHLQTIVNMENSGLVFLLTHDRFDEIANMYNVLSRVPEGPKAMSQCISTFLRERGQNIVRESGSSNPQQYIQDLLQLRDRCNVLLT-SLGNKQIFRNQINADFEYFINLNPKSTEFLSLFIDEKLRRGTKGMADQDVDAVFDKCTVLFRYLQEKDIFERYYKQHLAKRLLLSKSQSDDQEKSMISKLMAECGGVFTSKLEGMFKDMAVSKTLMEEFLQSTPVTPS----LDLYVRVLTTGLWPTQSVSPRVSLPEEAMAAFNVYSTFYLSKHSGRKISLHTNLGHAELSALFFG---NSDGSTAQDAAIVPLALRGSSSTSSSAVAPVSGLPGSPGVSEIIDQPSQA-SASRANA------------RKYILQVSTYQMVILMCFNRRNQFTFSELLTDTGIPERDLVRSLMALSLSRSTQRILCKEPKSK--EFEPTDVFTVNDTFTSRHYKVKVQNIAVRESEPERQETRTRIDENRRYVIEATIVRIMKTRKTLEHNQLLAEVIEQLKSRFRPTPTAIKQRIEALIEREFIARSDSDRKVYKYLA 801

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BLAST of Cullin 3 vs. TrEMBL
Match: A0A5J4NTB7 (Cullin 3 OS=Paragonimus westermani OX=34504 GN=DEA37_0001855 PE=3 SV=1)

HSP 1 Score: 897.886 bits (2319), Expect = 0.000e+0
Identity = 491/814 (60.32%), Postives = 618/814 (75.92%), Query Frame = 2

Query:  128 SNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS-PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT-GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAV--------TGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
              S +MRIKAF  S+++    +IWE LK AI+EIQKKNNSGLSFEELYRNAYT+VL KHGE+LY GTK +V EH+ ++++ ++ENLNN FL+YLN CWKDH TAMVMIRDILMYMDRVYV Q    +VY  G+ +F ++VLR   IRE LQ  LL+MV +ER+GEVI++SQIRDACQM VQLGV S  +Y EDFE VFL+QS+EFYR ESE+FL+EN  +I+YI +VEQRIEEE KRA HYLDPSTE KIV VLE++LIS+H++ IV M +SGL +ML   +  +IA+MY +LSRVD G ++MS  IS +LREQGR +V +   S P  ++ +LL LRD+A+ LL  AL+N ++FRNQIN+DFEYF+N N RSPE+LSLFID+KL+RGTKGM D DV+AVFDKCIVLFRYLQ+KDVFE YYK+HLAKRLL  KSQSDDQEK+MISKL+ ECG V+TSKLEGMFKDMA+SK LMD++   +  +N + G+DLYVRVLTTGLWPTQS+    +L EE  SAF+ Y  FYL KHNGR I+LQ N+G  E+S LFY  A +        + +   TA   P +   ++   R SS    SQI+  G  A+         G   S       +  + +++Y LQVSTYQM ILMKFN++S+YTF EL  ET IP+R+L RSL++L+L + +QRIL KEPK++  +    DVF +N+SF SKH K+KVQ+IT+KE EPER+ET+TRVDENR+YVIEATIVR+MKARKTL H  L+ EV EQLKSRF+PTP MIKQRIESL+ER++LAR +DD++ Y+YLA
Sbjct:   12 GGSTRMRIKAFANSMDESLANQIWEQLKSAIIEIQKKNNSGLSFEELYRNAYTLVLHKHGERLYAGTKALVCEHMIRVRDSIVENLNNKFLSYLNSCWKDHQTAMVMIRDILMYMDRVYVNQCNLPSVYKMGMTVFCNLVLRYSVIREHLQKTLLDMVRRERRGEVISRSQIRDACQMFVQLGVGSLSVYLEDFELVFLEQSREFYRAESEAFLAENTSAILYIKKVEQRIEEEIKRAHHYLDPSTEAKIVAVLEDQLISRHMETIVGMENSGLTHMLTHDRFEDIAAMYNVLSRVDEGPKIMSHYISMYLREQGRNIVRETGASTPQQYIQDLLQLRDRANDLLVRALNNQTIFRNQINSDFEYFVNLNPRSPEFLSLFIDEKLKRGTKGMADQDVDAVFDKCIVLFRYLQEKDVFEGYYKKHLAKRLLLSKSQSDDQEKNMISKLMAECGAVYTSKLEGMFKDMAVSKTLMDEFSVMLSSSNRSLGLDLYVRVLTTGLWPTQSIGCGEALPEEAASAFEVYRNFYLGKHNGRKISLQTNMGYAEISALFYGRASS--SEIGPTNLTLVGTAAVDPHNSAFLL---RGSSSGSSSQITSQGSQAMLVSGLPGSPGAPGSLDPPTFNVGRNTVRKYFLQVSTYQMEILMKFNRRSRYTFLELSSETNIPERELKRSLMALALGRSNQRILCKEPKTREIE--NNDVFFVNDSFVSKHIKVKVQSITVKENEPERQETRTRVDENRRYVIEATIVRVMKARKTLGHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARMEDDRRVYKYLA 818

[Close]

BLAST of Cullin 3 vs. TrEMBL
Match: C1LH18 (Cullin-3 OS=Schistosoma japonicum OX=6182 GN=CUL3 PE=2 SV=1)

HSP 1 Score: 894.419 bits (2310), Expect = 0.000e+0
Identity = 491/826 (59.44%), Postives = 622/826 (75.30%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDE-SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPAN-NTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNX--XXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTG------GDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
             S+TR+ E +    S K+RIKAFP S++++Y  ++W+ +K AI+EIQKKNNS LSFEELYRNAYT++LQKHGE+LY GT+ VV EH+ +I++ ++ENLNN FL YLN CWKDH TAM MIRDILMYMDRVYV       VY  G+ +F D+V+R   IRESLQ  LL+MV +ER+GEVI++SQIRDACQM VQLG  S  +Y EDFE+ FL+QS+EFYR+ESE+FL+EN  + +YI +VEQRIEEE +RA H+LD STEPKIV VLEEELIS+H++ IV M  SGL YML     ++IA+MY +LSRV+ G ++MS  IS +LREQGR+ V D  S +P   + +LL LRD+A+ LLT AL+N ++FRNQIN+DFEYF+N N RSPE+LSLFID+KL+RGTKGM D DV+A+FDKCIVLFRYLQ+KD+FE YYK+HLAKRLL  KSQSDDQEK MISKL+ ECG V+TSKLEGMFKDMA+SK LMD++   +   N N  +DLYVRVLTTGLWPTQ +    +L EE  +AF  Y  FYLSKHNGR I+LQ N+G  ELS +FY   PN+         S + S T G      F I   +  SS    SQ    G      G           N+    + S +++Y LQVSTYQM+ILMKFN++++Y+F EL  ET IP+R+L RSL++L+L + SQRIL KEPK++  D+  TDVF +N+SF SKH K++VQ+IT+KE+EPER+ET+T+VDENR+YVIEATIVR+MKARKTLSH  L+ EV EQLKSRF+PTP MIKQRIESL+ER++LAR +DD++ Y+YLA
Sbjct:    4 GSSTRRTEVT----SAKVRIKAFPPSIDERYANQLWDQIKSAIIEIQKKNNSCLSFEELYRNAYTLILQKHGERLYAGTEAVVREHMIRIRDSIVENLNNKFLTYLNSCWKDHQTAMGMIRDILMYMDRVYVGPHNLDGVYKMGMTVFCDLVVRYPIIRESLQKTLLDMVRRERRGEVISRSQIRDACQMFVQLGAGSLRVYLEDFEQPFLEQSREFYRIESENFLAENTSASLYIKKVEQRIEEEIRRAHHHLDASTEPKIVSVLEEELISRHMETIVGMEDSGLTYMLTHDHFSDIAAMYNVLSRVEEGPKIMSNYISLYLREQGRSTVRDTGSSTPQQHIEDLLRLRDRANELLTRALNNQTIFRNQINSDFEYFVNLNPRSPEFLSLFIDEKLKRGTKGMADQDVDAIFDKCIVLFRYLQEKDLFEGYYKKHLAKRLLLSKSQSDDQEKIMISKLMAECGAVYTSKLEGMFKDMAVSKTLMDEFNGVLSNGNRNLNLDLYVRVLTTGLWPTQIITSTEALPEEADAAFKVYKSFYLSKHNGRKISLQTNMGYAELSAVFYGR-PNADVNNTSQGCSVADSHTHG------FLIHGCNTGSSNQVTSQCGQHGLISGLPGSPGAPKTLDPPNAISASSRSNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTR--DIESTDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPLMIKQRIESLIEREFLARLEDDRRVYKYLA 816

[Close]

BLAST of Cullin 3 vs. TrEMBL
Match: G4VPI9 (Putative cullin OS=Schistosoma mansoni OX=6183 GN=Smp_031000.2 PE=3 SV=1)

HSP 1 Score: 891.338 bits (2302), Expect = 0.000e+0
Identity = 486/804 (60.45%), Postives = 614/804 (76.37%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDE-SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPAN-NTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSS--GIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            K+RIKAFP S++++Y  ++W+ +K AI+EIQKKNNS LSFEELYRNAYT++LQKHGE+LY GT+ VV EH+ KI++ ++ENLNN FL YLN CWKDH TAM MIRDILMYMDRVYV       VY  G+ +F D+V+R   IRE LQ  LL+MV +ER+GEVI++SQIRDACQM VQLG  S  +Y EDFE+ FL+QS+EFYR ESE+FL+EN  + +YI +VEQRIEEE +RA H+LDPSTEPKIV VLEEELIS+H++ IV M  SGL YML     ++IA+MY +LSRV+ G ++MS  IS +LREQGR  V D  S +P   + +LL LRD+A+ LLT AL+N ++FRNQIN+DFEYF+N N RSPE+LSLFID+KL+RGTKGM D DV+A+FDKCIVLFRYLQ+KD+FE YYK+HLAKRLL  KSQSDDQEK MISKL+ ECG V+TSKLEGMFKDMA+SK LMD++   +   N N  +DL VRVLTTGLWPTQ+ N N +L EE  +AF  Y  FYLSKHNGR INLQ N+G  ELS +FY   PN     +     SS T  ++   +    + S   +     Q   +G     G   +    +L  TSS   +++Y LQVSTYQM+ILMKFN++++Y+F EL  ET IP+R+L RSL++L+L + SQRIL KEPK++  D+  TDVF +N+SF SKH K++VQ+IT+KE+EPER+ET+T+VDENR+YVIEATIVR+MKARKTLSH  L+ EV EQLKSRF+PTP MIKQRIESL+ER++LAR +DD++ Y+YLA
Sbjct:   16 KVRIKAFPPSIDERYANQLWDQIKSAIIEIQKKNNSCLSFEELYRNAYTLILQKHGERLYAGTEAVVREHMIKIRDSIVENLNNKFLTYLNSCWKDHQTAMGMIRDILMYMDRVYVGPHNLDGVYKMGMTVFCDLVVRYPIIREHLQKTLLDMVRRERRGEVISRSQIRDACQMFVQLGAGSLRVYLEDFEQPFLEQSREFYRTESENFLAENTSASLYIKKVEQRIEEEVRRAHHHLDPSTEPKIVVVLEEELISRHMETIVGMEDSGLTYMLTHDHFSDIAAMYGVLSRVEEGPKIMSNYISLYLREQGRNTVRDTGSSTPQQHIQDLLQLRDRANELLTRALNNQTIFRNQINSDFEYFVNLNPRSPEFLSLFIDEKLKRGTKGMADQDVDAIFDKCIVLFRYLQEKDLFEGYYKKHLAKRLLLSKSQSDDQEKIMISKLMAECGAVYTSKLEGMFKDMAVSKTLMDEFNAVLSNGNRNLNLDLCVRVLTTGLWPTQATNSNEALPEEADTAFKVYKNFYLSKHNGRKINLQTNMGYAELSAVFYGR-PN---ADINTPQISSVTDSHIHSFLIHGSSSSNQVTSQSSQQTPISGLPGSPGAPKTLDPPNLISTSSRPNVRKYFLQVSTYQMIILMKFNRRNRYSFIELASETNIPERELKRSLMALALGRCSQRILCKEPKTR--DIESTDVFYVNDSFVSKHIKVRVQSITVKESEPERQETRTKVDENRRYVIEATIVRVMKARKTLSHGQLVVEVIEQLKSRFVPTPVMIKQRIESLIEREFLARLEDDRRVYKYLA 813

[Close]

BLAST of Cullin 3 vs. Ensembl Cavefish
Match: cul3b (cullin 3 [Source:NCBI gene;Acc:103024283])

HSP 1 Score: 771.541 bits (1991), Expect = 0.000e+0
Identity = 428/807 (53.04%), Postives = 567/807 (70.26%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K+++ VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ LQ  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N N RSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                         ED               GS I   GG  VTG              S  +++ILQVST+QM ILM FN + K TF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   14 KMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVRDDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLQQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNPRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQSTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATFYGAIKK--------------------ED---------------GSDIG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 767

[Close]

BLAST of Cullin 3 vs. Ensembl Cavefish
Match: cul3a (cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376])

HSP 1 Score: 767.689 bits (1981), Expect = 0.000e+0
Identity = 426/807 (52.79%), Postives = 564/807 (69.89%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LLNM+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S +LREQG+A+V +E   K+P+ ++  LL L+ +    L E+  N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE + DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMFKDM+IS   MD++   ++    +  GVDL VRVLTTG WPTQ+     ++    + AF+ + +FYL+KH+GR + LQ ++G+ +L+  FY                             PI           GS++   GG  VTG              S  +++ILQVST+QM ILM FN + K  F+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     +FT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL+ RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:  133 KMRIRAFPMTMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLISKVREDVLISLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLNMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKTRFDRFLQESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVEYILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFKDMSISNTTMDEFRQHLQSTGVSLGGVDLTVRVLTTGYWPTQAATPKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATFYG----------------------------PIKKED-------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKCVFEEIQQETDIPERELVRALQSLACGKTTQRVLTKEPKSKEIE--NGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRVRFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 886

[Close]

BLAST of Cullin 3 vs. Ensembl Cavefish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 294.664 bits (753), Expect = 1.600e-86
Identity = 184/567 (32.45%), Postives = 310/567 (54.67%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAFP--ASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            S+ +  F  S    + K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K   KLY   + V  +H++ +I +      +  FL  +++CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  ++ +++++      +L ++ +ER GE I +S         +   ++   IY++ FE+ FL+++   Y       L +      Y++ V +R+EEES+ + H L P  E  ++  +E++L+ +H+   +     GLN++L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK  +++      +  F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  130 SAGSATFTNSKPGAAKKLVIKNFKEKPKLPENYTHETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISPKLYKQLRAVCEDHIKAQIDQFREYPFHVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRFYIISDLKVQSKTIDGILLLIERERSGEAIDRSL-----LRSLLSMLSDLQIYQDSFEQRFLEETNRLY-AAEGQRLMQEREVPEYLHHVNKRLEEESRPSHHILGP--EKPLIATVEKQLLGEHLTATL---QKGLNHLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDSIIDVCFMKNEKFVNAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQYMQCQNIPGNIELTVNILTMGYWPT-YVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 683

HSP 2 Score: 102.064 bits (253), Expect = 9.449e-22
Identity = 75/177 (42.37%), Postives = 109/177 (61.58%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++ + FN+  ++ +  L       D +L R+L SL+  K   R+L K PKSK  D+   D F+ N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK    P    + +RIESL++RDY+ R  ++   Y Y+A
Sbjct:  690 LQVSLFQTLVRLMFNEGEEFPWKRL------KDGELRRTLQSLACGKA--RVLTKIPKSK--DVEDGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK---FPVKVSVHKRIESLIDRDYMERDKENPNQYNYVA 853

[Close]

BLAST of Cullin 3 vs. Ensembl Cavefish
Match: cul4a (cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357])

HSP 1 Score: 258.455 bits (659), Expect = 2.327e-75
Identity = 158/449 (35.19%), Postives = 246/449 (54.79%), Query Frame = 2

Query:  446 MIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDW----LNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            MIR I +++DR YV Q     ++++TGL +FR  ++ +  ++      +L  + +ER GE + +S +R    ML  L V     Y+E FE+ FL  +   Y       L        Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+  I+     GL+ +L+E + T +  +Y+L S+V  GL ++ Q    +++  G  +V    K     V ELL  +DK   +       +  F N +   FE FIN     P E ++ ++D KLR G K   + ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +     N  +P+N   ++L V +LT G WPT +  + + L  E+    + +  FYL KH+GR +  QP LG+  L   F
Sbjct:    1 MIRSIFLFLDRTYVLQNSLLPSIWDTGLELFRTHIVSDNMVQSRTVQGILEQIERERNGETVDRSLLRSLLGMLSDLQV-----YKESFEQKFLVDTDRLY-AAEGQRLMLERDVPEYLHHVARRLEEENDRVISYLDQSTQKPLISTVEKQLLGEHMTAIL---QKGLSTLLDENRVTELTLLYQLFSKVKGGLPVLLQFWRDYIKSFGGEIVGSPEKDK-DMVQELLDFKDKMDNVAQRCFQRNESFINAMKEAFESFINKRPNKPAELIAKYVDSKLRAGNKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQSEPSN---IELTVNILTMGYWPTYT-PMEVHLPAEMVKLQEVFKMFYLGKHSGRKLQWQPTLGHAVLKAEF 435

HSP 2 Score: 109.768 bits (273), Expect = 1.954e-24
Identity = 76/177 (42.94%), Postives = 112/177 (63.28%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  ++T +E+   T I + +L R+L SL+  K   R+L K P+ K  D+   D F  N  F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A +VRIMK RKTLSHNLL++E+  QLK  F   P  +K+RIESL++RDY+ R  +    Y Y+A
Sbjct:  442 LQVSLFQTLVLLMFNEGEEFTLEEIQTATGIEEGELKRTLQSLACGKA--RVLNKNPRGK--DVEDGDRFNFNIDFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKESPNQYHYVA 612

[Close]

BLAST of Cullin 3 vs. Ensembl Cavefish
Match: ENSAMXT00000057183.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001049.1:257741:270576:1 gene:ENSAMXG00000034138.1 transcript:ENSAMXT00000057183.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 241.506 bits (615), Expect = 5.589e-69
Identity = 155/453 (34.22%), Postives = 252/453 (55.63%), Query Frame = 2

Query:  443 VMIRDILMYMDRVYVAQTEKQNVYNT------GLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYL--SLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG-VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            +MIR I     R YV      ++  T      GL +FR  ++ +++++      +L ++ +ER GE I +S +R    M     ++   IY++ FE+ FL+++   Y  E +  + E  +   Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+   +     GLN++L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK  +++      +  F N +   FE FIN     P  L  S ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++  N  G ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:   17 IMIRSIFFVFGRTYVLTNLCCHLSGTYLLLDMGLELFRFYIISDLKVQSKTIDGILLLIERERSGEAIDRSLLRSLLSM-----LSDLQIYQDSFEQRFLEETNRLYAAEGQRLMQEREVP-EYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATL---QKGLNHLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDSIIDVCFMKNEKFVNAMKEAFETFINKRPNKPAELIGSKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQYMQCQNIPGNIELTVNILTMGYWPT-YVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 458

HSP 2 Score: 116.701 bits (291), Expect = 1.608e-26
Identity = 80/177 (45.20%), Postives = 116/177 (65.54%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  +++ +E+   T I D +L R+L SL+  K   R+L K PKSK  D+   D F+ N+ F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK  F   P  +K+RIESL++RDY+ R  ++   Y Y+A
Sbjct:  465 LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGK--ARVLTKIPKSK--DVEDGDKFSCNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 635

[Close]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 287.73 bits (735), Expect = 8.000e-87
Identity = 190/561 (33.87%), Postives = 306/561 (54.55%), Query Frame = 2

Query:  128 SNSNKMRIKAF--PASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXX-----QCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILM---DDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
             ++ K+ IK F     L D Y  + W+ L++A+  IQ   +   + EELY+    +   K   KLY   + V  EH   I+ Q+      +  + L      +CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  V+ +  ++      LL ++ +ER GE + +S +R    M     ++   IY++ FE+ FL ++   Y  E +  + E  +   Y++ V +R+EEES R   YLD ST+  ++  +E++L+ +H+  I+     G   +L+E +   ++ +Y+L SRV  G+Q++ Q  + +++  G  +VV+  K     V ELL  ++K   ++         F N +   FE FIN     P E ++ ++D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECGG FTSKLEGMFKDM +SK +M     ++ +   ANN  ++L V +LT G WPT +  + + L  E+    + +  FYL KH+GR +  QP+LG+  L   F
Sbjct:   35 GSAKKLVIKNFRDKPKLPDSYPAETWQKLQEAVQAIQNSTSIKYNLEELYQAVENLCSYKISAKLYLQLRQVCEEH---IRAQIQHFWAGSMDSVLFLKHIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRTHVVSDRLVQNRTIDGLLLLIERERSGETVDRSLLRSLLSM-----LSDLQIYQDCFEQRFLVETNRLYAAEGQRLMQEREVP-EYLHHVNKRLEEESDRIITYLDQSTQKSLIATVEKQLLGEHLTAIL---QKGAANLLDENRIPELSLLYQLFSRVKGGIQVLLQHWADYIKVFGTTIVVNPEKDK-TMVQELLDFKEKVDVIVEVCFQRSDKFINAMKEAFETFINKRLNKPAELIAKYVDSKLRAGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGGAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNDANN--IELTVNILTMGYWPTYT-PMEVHLPPEMVKLQEVFKTFYLGKHSGRKLQWQPSLGHCVLKSEF 579

[Close]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887])

HSP 1 Score: 213.001 bits (541), Expect = 1.644e-58
Identity = 157/591 (26.57%), Postives = 289/591 (48.90%), Query Frame = 2

Query:  161 PASLNDQYVGKIWETLKKAIVEIQKKNNSGLS-FEELYRNAYTMVLQKH----------------------------GEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQN------VYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNS--------TL-IYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS----PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN---------SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVEL 1762
            P  L    + +IW+ LK  I ++  + +   S + ELY + Y      H                            G +LY   K  +  +L  + +   + ++   L +  Q W+D+  +  ++  I  Y++R +V +   +       +Y+  L+ +R+ + +   + + + + +L ++ KER GE I    I       V+LG+N         TL +Y+E FE  FL  ++ FY     +     N    Y+ + E R+ EE +R + YL  ST  ++ +  E+ LI KH++      +S    +L++ ++ ++A MY L+SR+ +GL  +   + + +  QG + +    +     P  +V  +L +  K + L+  A +N + F   ++     FIN N         S+SPE L+ + D  L++ +K  ++ ++E   ++ +V+F+Y++DKDVF+R+Y + LAKRL+   S SDD E SMISKL   CG  +TSKL+ MF+D+ +SK L + + N +  +    +D  ++VL++G WP Q  +   +L  E++ +   +  FY S+H+GR ++    L   EL
Sbjct:    7 PHGLKQIGLDQIWDDLKAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQANQARSGAMANTSKNKKGQPSGGAQFVGLELYKRLKDFLKMYLLNLLKDGEDLMDEGVLKFYTQQWEDYRFSSKVLNGICSYLNRHWVRRECDEGRKGIYEIYSLALVTWRECLFK--PLNKQVTNAVLKLIEKERTGETINTRLISGVVGSYVELGLNEDDLHAKGPTLSVYKEAFESQFLLDTERFY-TRESTDFLSQNPVTEYMKKAETRLLEEQRRVQVYLHESTHDELARKCEQVLIEKHLENF----YSEFQNLLDDDKNEDLARMYSLVSRILDGLGELKSLLETHIHNQGLSAIEKCGEGALNDPKIYVQTILDVHKKYNALVMSAFNNDAGFVASLDKACGRFINTNAVTKMAQTSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQRFYAKMLAKRLVNHNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKNHLANSEPLDLDFSIQVLSSGSWPFQQ-SCTFALPSELERSHQRFTTFYSSQHSGRKLSWLYQLSKGEL 589

HSP 2 Score: 104.375 bits (259), Expect = 3.359e-23
Identity = 70/190 (36.84%), Postives = 108/190 (56.84%), Query Frame = 2

Query: 1979 ITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTD---LLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +T+    RY LQ ST+QM +L+++N +  YT  +L + T I    L + L  L    +  ++LV E ++ + D   L P  +  +   + +K  ++ +      E + E+  T   ++E+RK VI+A IVRIMK RK L H  L+AEV  QL SRF P   +IK+ I+ L+E++YL R D +K TY YLA
Sbjct:  590 VTNCFKNRYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMDILVQVLQIL----LKSKLLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 775

[Close]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Match: cul1b (cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887])

HSP 1 Score: 211.075 bits (536), Expect = 3.836e-58
Identity = 154/562 (27.40%), Postives = 286/562 (50.89%), Query Frame = 2

Query:  185 VGKIWETLKKAIVEIQKKNNSGLS-FEELYRNAYTMVLQKH------------GEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQC---WKDHHTAMVMIRDILMYMDRVYVAQTEKQN------VYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTL-IYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS----PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN---------SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVEL 1762
            + +IW+ LK  I ++  + +   S + ELY + Y      H            G +LY   K  +  +L  + ++V   L    L++  +C   W+D+  +  ++  I  Y++R +V +   +       +Y+  L+ +R+ + +   + + + + +L ++ KER GE I    I         +G  +TL +Y+E FE  FL  ++ FY     +     N    Y+ + E R+ EE +R + YL  ST  ++ +  E+ LI KH++      +S    +L++ ++ ++A MY L+SR+ +GL  +   + + +  QG + +    +     P  +V  +L +  K + L+  A +N + F   ++     FIN N         S+SPE L+ + D  L++ +K  ++ ++E   ++ +V+F+Y++DKDVF+R+Y + LAKRL+   S SDD E SMISKL   CG  +TSKL+ MF+D+ +SK L + + N +  +    +D  ++VL++G WP Q  +   +L  E++ +   +  FY S+H+GR ++    L   EL
Sbjct:    3 LDQIWDDLKAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQANQPSGGAQFVGLELYKRLKDFLKMYLLNLLKKVPAALFRPRLSH--KCTVQWEDYRFSSKVLNGICSYLNRHWVRRECDEGRKGIYEIYSLALVTWRECLFK--PLNKQVTNAVLKLIEKERTGETINTRLISGV------VGSYATLSVYKEAFESQFLLDTERFY-TRESTDFLSQNPVTEYMKKAETRLLEEQRRVQVYLHESTHDELARKCEQVLIEKHLENF----YSEFQNLLDDDKNEDLARMYSLVSRILDGLGELKSLLETHIHNQGLSAIEKCGEGALNDPKIYVQTILDVHKKYNALVMSAFNNDAGFVASLDKACGRFINTNAVTKMAQTSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQRFYAKMLAKRLVNHNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKNHLANSEPLDLDFSIQVLSSGSWPFQQ-SCTFALPSELERSHQRFTTFYSSQHSGRKLSWLYQLSKGEL 548

HSP 2 Score: 102.449 bits (254), Expect = 1.309e-22
Identity = 69/192 (35.94%), Postives = 110/192 (57.29%), Query Frame = 2

Query: 1979 ITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIP--DRDLTRXXXXXXXXKISQRILVKEPKSKSTD---LLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +T+    RY LQ ST+QM +L+++N +  YT  +L + T I    +D+   L+ +    +  ++LV E ++ + D   L P  +  +   + +K  ++ +      E + E+  T   ++E+RK VI+A IVRIMK RK L H  L+AEV  QL SRF P   +IK+ I+ L+E++YL R D +K TY YLA
Sbjct:  549 VTNCFKNRYTLQASTFQMAVLLQYNSEDAYTVQQLHENTQIKMKTKDI---LVQVLQILLKSKLLVLEDENTNVDEVDLQPETLIRLFLGYKNKKLRVNINVPMKAEQKQEQETTHKNIEEDRKLVIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDMLIEKEYLERVDGEKDTYSYLA 737

[Close]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032])

HSP 1 Score: 162.155 bits (409), Expect = 1.198e-41
Identity = 109/355 (30.70%), Postives = 183/355 (51.55%), Query Frame = 2

Query:  692 IYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS--PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN-----SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPAN---NTGVDLYVRVLTTGLWPTQSL-NINISLSEEVQSAFDAYAKFYLSKHNGR 1723
             Y++ FE  FL ++ E+++ E+   L   N S  Y+ +V  R+++E  R R YL PS+  K++   ++ +++ H+  +    HS    ++ ++   ++A+MY LL  V   LQ M       +R++G   + + S    P  FV  +L +  K   L+T  L     F + ++      +N+       +SPE L+ + D  L++  KGM + +V+      IV+F+Y+ DKDVF+++Y + LAKRL+   S S D E+SMI+KL   CG  FTSKL  M+ DM++S  L + + N IK      + GV   + VL  G WP   L +    + +E++     +  FY    NGR
Sbjct:  200 FYQDVFESAFLVETGEYFKQEASRLLQTCNCS-QYMQQVLGRLKDEEVRCRKYLHPSSYSKVISECQQRMVADHLQFL----HSECQTIVRQELRDDMANMYTLLRTVPQALQHMVTEQQEHIRQEGLKAISNLSHENMPTQFVESVLEVHSKYVQLITSVLSGDQQFMSALDKACSAVVNYREPKSLCKSPELLAKYCDGMLKKTAKGMTENEVDDKLSNSIVVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEESMINKLKQACGYEFTSKLHRMYTDMSLSADLNNKFGNFIKEQETPIDLGVGFQIYVLQAGAWPLSQLPSTPFVIPQELEKCVRMFEIFYNDSFNGR 549

HSP 2 Score: 106.686 bits (265), Expect = 5.857e-24
Identity = 67/182 (36.81%), Postives = 108/182 (59.34%), Query Frame = 2

Query: 1997 KRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXX-XXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            K Y+  V+TYQM +L+ FN   + T+ EL   T + +R+L +++ SL   K+           K  ++ P  +F++N  F+SK  K K+ +   K   + E  +T++ VDE+RK  ++A IVRIMK+RK L HN LI EV  Q ++RF+P+  MIK+ IE L+++ Y+ R+ +    Y Y+A
Sbjct:  569 KPYVATVTTYQMGVLLAFNGAEQVTYRELEYSTQLNERELVKTIRSLIDVKLVN------SSGKEDEITPECIFSLNMEFSSKRTKFKITSAMQKDTPQQEVEQTRSAVDEDRKMYLKAAIVRIMKSRKVLKHNALIQEVISQSRARFIPSVSMIKKCIEDLIDKQYIERNQNSTDEYNYVA 744

[Close]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Match: cul5a (cullin 5a [Source:ZFIN;Acc:ZDB-GENE-030131-5426])

HSP 1 Score: 54.299 bits (129), Expect = 8.263e-8
Identity = 59/269 (21.93%), Postives = 119/269 (44.24%), Query Frame = 2

Query:  563 IRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNST---LIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIA----FVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINH---------------------NSRSPEYLSLFIDDKLRR 1285
            I+  LQ + + +V  ER GE      +    +  V L  N+     IY E+FEK +LD +  FYR ++ ++L +N +   ++   + +++EE +RA  YL+   +   V+ L +  ++  +        +  + M+   +   +  M++L+ RV  G++ M + +   +   G A +V  ++S       +V +LL L  + S L+ +A  +   F    +  ++  +N                       S+ PE L+ + D  LR+
Sbjct:  154 IKGRLQDSAMKLVHSERLGEAFDSQLVIGVRESYVNLCSNAEDRLQIYRENFEKAYLDATDTFYRTQAPAYLQQNGVQ-NFMKYADAKLKEEEQRALRYLETRKDCNSVQALVDCCVNALVTSFKETILAECSGMIKANETEKLQLMFQLMDRVPAGIEPMLKDLEEHIVSAGLADMVATAESITTDSEKYVEQLLMLFHRFSRLVKDAFRDDPRFLTARDKAYKAVVNDATIFKLELPSKQKGLSSKTQPESKCPELLANYCDMLLRK 421

[Close]

BLAST of Cullin 3 vs. Ensembl Yeast
Match: CDC53 (Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant [Source:SGD;Acc:S000002290])

HSP 1 Score: 132.88 bits (333), Expect = 2.766e-32
Identity = 121/497 (24.35%), Postives = 226/497 (45.47%), Query Frame = 2

Query:  419 WKDHHTAMVMIRDILMYMDRVYVAQTE---KQNVYNTG---LIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVN-------STLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGR-------------------------AVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN-------------SRSPEYLSLFIDDKLRRGTK-----GMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTG----VDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVI 1729
            WK      + +     YM+R +V +     K+++++     L+ +++++      ++ L + LL+ V   R+G++I +S I  A + LV LG++       +  +Y + FEK FL +++E+Y  +  +   E +    YI    + I+ E K    Y D  T+  +   L + LI+ HI+++ N        +L+ +    I S+Y L+ R    +  M+    +++++ G                          A++   S SP  ++ +LL + D  S +  E+  +       ++     FIN N             S++ E L+ + D  L++ TK      M D D+       I +F+YL DKD FE +Y++  AKRL+   S S + E+++I +L       +T K+  MF+D+ +SKIL DD+  ++K   +       DL   VL   +WP     +   L +E+  + +   + Y  KHNGR++
Sbjct:  117 WKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFD--PSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYY-TQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLEN----EFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDI-------ITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRIL 599

HSP 2 Score: 61.2326 bits (147), Expect = 5.526e-10
Identity = 31/74 (41.89%), Postives = 46/74 (62.16%), Query Frame = 2

Query: 2318 VDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            ++  R+  +EA IVRIMKA++ L H  L+ E   Q   RF     M+K+ I+SL+++ YL R DD  ++Y YLA
Sbjct:  743 LNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDG-ESYAYLA 815

[Close]

BLAST of Cullin 3 vs. Ensembl Yeast
Match: CUL3 (Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 [Source:SGD;Acc:S000003235])

HSP 1 Score: 115.931 bits (289), Expect = 5.047e-27
Identity = 143/558 (25.63%), Postives = 253/558 (45.34%), Query Frame = 2

Query:  203 TLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXX--XXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQ-----SNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIV-NMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDE-----SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFE----------YFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFD--KCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDW----LNSIKPANNTGVDLYVRVLTTGLWPTQSLNI---NISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYS 1780
            T+K AI  I   + + LSFE++Y+  YT+VL K G  LYN  K  + + L  ++E +++    +  FL  + + W+       +  D++MYMD+VY        VY+  L +FR  +L+                + N+ + + +   + K  I     M+  L  N    +  DFE V +  ++E+Y    +  L     S+  I ++ Q    ES     +L+  +  K+  VLE  LI   + +I+ +++H  +  + N K    +  +Y L S     + ++ + I S++ +    +  +E      ++ I + +E++ L     + L E++D  S+  N +  D            YF    +   EYLS ++D  ++R TK  D   V+   D      L   L +KD+FE+ YK+ L++RLL  +S   + EK M+  +    G  FTSKLE M +D+++S  +   +    +NSI+      +    +VLT   WP QS N     ISL   +      +  +Y  K+  RV+    +L  +E+   F S
Sbjct:   28 TVKYAIDHIYSDDMADLSFEQVYKTIYTIVLNKKGPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLI----GMMETLHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLTPIESLEKIRKLRQF---ESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAM-VISNGKL---LQEIYDLSSEEKYRVTVI-ESIKSYINKNAINIPFNEGNRKKGQNAITWSSEIVELYRSQHSFL-ESIDFGSVRLNNLTGDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKR-TKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSLV-EIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQHSTINSIE-----YLSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNS 565

HSP 2 Score: 62.003 bits (149), Expect = 3.040e-10
Identity = 60/199 (30.15%), Postives = 99/199 (49.75%), Query Frame = 2

Query: 1970 HLGITSSGIK----RYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQ--NXXXXXXXXXXXXXXXXVDE-NRKYVIE--ATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            HL +   G +     Y +  S Y  VI + F    + T  E+ + T IP  D+   ++S+S      +IL K   S +        F++N  F+S + K+KV      +   + +   T + VD  + + V+E  A IVRIMK    LSH  L+   T++ +SR   TP ++K+ I+ L+E++Y+ R+ DD   Y YL+
Sbjct:  553 HLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIP-RCKILKKSSSSGNMK------FSVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS 744

[Close]

BLAST of Cullin 3 vs. Ensembl Nematostella
Match: EDO35230 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM65])

HSP 1 Score: 679.093 bits (1751), Expect = 0.000e+0
Identity = 388/759 (51.12%), Postives = 517/759 (68.12%), Query Frame = 2

Query:  287 MVLQKHGEKLYNGTKVVVTEHLQ-KIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDE----SKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPA--NNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX-XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            MVL KHGE+LYNG K VVTEHL+ KI++ V+ +LNNNFL+ LN  W DH T+MVMIRDILMYMDRVYV Q    NVYN GLI+FRD V+R   IR+ L   LL++V KER+GEV+ +  IR+ACQMLV LG++S  +YEEDFE+ FL++S EFY++E + FL+EN+ SI YI +VE RI EES+RA+HYLDPSTE  +VKV+EEELI KH+  IV+M +SG+ +ML   +  ++A MY+L  RV  GL+ +  C+  +LREQG+AVVVDE    +++PI+ +  LL L+D+    L     +  LF+  I ++FEYF+N N +SPE+LSLFIDDKL++G KG  + +VE V DKC+VLFR+LQ+KDVFERYYKQHLAKRLL  KS SDD EK+MISKL  ECG  FTSKLEGMFKDM +S    +++   +  +  N  GVDL VRVLTTG WPTQS N   ++  + Q AFD + +FYL  H+GR + LQP LG  EL+  F                                  P +    S G                              +++I Q+S+YQM ILM FN + ++T++++L++T IP+RDL R+L SL+  K +QR+L KEPK K  D+  TDVF++N+ FTSK +++K+Q +  K     ER+ET+T+VDE+RK+ IEA IVRIMKARK   HNLL+AEVTEQLK+RF+P+PQ+IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:    1 MVLHKHGERLYNGLKQVVTEHLEDKIRKDVVASLNNNFLDTLNAAWNDHQTSMVMIRDILMYMDRVYVQQNGVDNVYNLGLILFRDKVVRYGNIRDHLCQTLLSLVRKERRGEVVDRMAIRNACQMLVILGIDSRHVYEEDFERPFLEESAEFYKMEGQKFLAENSASI-YIQKVETRINEESERAKHYLDPSTEESVVKVVEEELIRKHMKTIVDMENSGVIHMLKHDKIEDLARMYRLFYRVKEGLKTVCDCMRGYLREQGKAVVVDEESETARNPISCIQNLLELKDRFDHFLHNGFSSDRLFKQAIGSEFEYFLNLNGKSPEFLSLFIDDKLKKGVKGYSEQEVEVVLDKCMVLFRFLQEKDVFERYYKQHLAKRLLLQKSVSDDSEKNMISKLKTECGCQFTSKLEGMFKDMTVSHTTNEEFRQHLSNSQINLLGVDLIVRVLTTGFWPTQSGNHKCNVPPQAQHAFDCFKRFYLGNHSGRQLTLQPQLGTAELNATF---------------------------------PPVKKEGASLGQ-----------------------------RKHIFQMSSYQMCILMLFNSQERWTYEDILQQTLIPERDLNRALQSLACGKATQRVLSKEPKGK--DITATDVFSVNDLFTSKLHRVKIQTVLAKGESEPERKETRTKVDEDRKHEIEAAIVRIMKARKKRPHNLLVAEVTEQLKARFLPSPQVIKKRIEGLIEREYLARTPEDRKVYLYVA 694

[Close]

BLAST of Cullin 3 vs. Ensembl Nematostella
Match: EDO35660 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKY8])

HSP 1 Score: 241.891 bits (616), Expect = 4.253e-70
Identity = 143/396 (36.11%), Postives = 229/396 (57.83%), Query Frame = 2

Query:  584 NLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIK----PANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNV 1756
             LL M+ KER GE + +S ++   +ML  +      +YE+ FE  FL+ +   Y  E   ++ E ++   Y+  V++R++EE  R  HYLD ST   ++  +E++L+ +H+  I+     G + ++   +  ++A MY+L  RV  G++ +    S F+++QG ++V++  K     V ELL  +++  T++ EA      F N +   FE FIN     P E ++ F+D KLR G K   + ++E + D+ +V+FR++  KDV+E +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +   ++    P N   +D+ V +LT G WPT  L +++ L  E+    + + KFYL+KH+GR +  Q  LG+ 
Sbjct:   13 GLLQMIEKERHGEAVDRSLLKSLLRMLADIQ-----MYEDAFESKFLEATDVLYSQEGNRYMQETDVP-KYLAHVDKRLKEEMDRLIHYLDQSTRKPLILCVEKQLLGQHLTSIL---QKGFDNLMLSNRIADLALMYQLFGRVRKGMEELCAAFSGFIKKQGISIVLNPEKDK-TMVQELLDFKEQLDTMIAEAFMKSEKFVNAMKESFESFINKRPNKPAELIAKFVDSKLRAGNKEATEEELERLLDRIMVIFRFIHGKDVYEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGAAFTSKLEGMFKDMELSKDVMVQFRQYLQHQSLPWN---MDMVVSILTMGYWPT-YLPMDVHLPTEMVHYQETFKKFYLAKHSGRKLQWQNTLGHC 394

HSP 2 Score: 112.849 bits (281), Expect = 6.164e-26
Identity = 76/177 (42.94%), Postives = 115/177 (64.97%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+ ++Y+ +++ + T + D +L R+L SL+  K   R++ K P+SK  D+   D+FT N+ F  K  +IK+  + +KET  E   T  RV ++R+Y I+A IVRIMK RKTLSH LL++E+  QLK    PT   +K+RIESL+ERDY+ R  +    Y Y+A
Sbjct:  407 LQVSLFQTLVLLMFNEGNEYSLEDIKQATGVEDGELRRTLQSLACGKA--RVIKKRPQSK--DIEDGDIFTFNKEFKHKLIRIKINQVQMKETPEENVNTTERVFQDRQYQIDAAIVRIMKTRKTLSHTLLVSELYTQLKFPVKPTD--LKKRIESLIERDYMERDKEIANQYHYVA 577

[Close]

BLAST of Cullin 3 vs. Ensembl Nematostella
Match: EDO37570 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFF7])

HSP 1 Score: 209.149 bits (531), Expect = 5.189e-57
Identity = 148/579 (25.56%), Postives = 285/579 (49.22%), Query Frame = 2

Query:  155 AFPASLNDQYVGKIWETLKKAIVEI-QKKNNSGLSFEELYRNAYTMVLQKH----------------------GEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQN------VYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVN---------STLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESK------SPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN---------SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVIN 1732
            A P  L    + +IW+ LK+ I  +  +++ S   + ELY + Y      H                      G +LY   K  +  +L  +++   + ++ + L + +  W+D+  +  ++  +  Y++R +V +   +       +Y   L+ +R+ + R   + + + + +L ++ +ER GE I    +    Q  V+LG+N         +  +Y++ FE VFL+ ++ FY           N    Y+ + E R+ EE +R   YL  ST+ ++ +  E+ LI KH+D    + ++    +LN+ ++ ++  MY L SR+ +GL  +   + + +  QG   +    +      +P ++V  ++ +    +     +  N + F   ++  F  FIN N         S+SPE L+ + D  L++ +K  ++ ++E + +  +V+F+Y++DKDVF+++Y   LAKRL+   S SDD E SMISKL   CG  +TSKL+ MF+D+ +SK L D +   +    +  +D  ++VL++G WP Q  +   SL  E++ +   +  FY S+H+GR ++
Sbjct:    6 ANPHGLRQINLDEIWDDLKEGIQHVYNQQSMSKQRYMELYTHVYNYCTSVHQQSQSRVPKQKKAPNQGGAQFVGHELYKRLKEFLKSYLLNMQKDGADLMDESVLRFYSSRWEDYRFSSKVLNGVCAYLNRHWVRRECDEGRKGIYEIYQLALVTWREHLFR--PLNKQVTNAVLRLIERERNGETINTRLVSGVIQCYVELGLNEEEQSSKGPALTVYKQYFESVFLEDTERFY-TAESVEFLRENPVTEYMKKAEARLLEEQRRVNVYLHESTQDELARKCEQVLIEKHLD----IFYAEFQNLLNDDKNEDLGRMYSLGSRIPDGLVQLRTLLENHICYQGLNALEKCGEQAYNVSTPASYVIIIIFVSKMCNYYFIMSFKNDAGFVAALDKAFGKFINSNAVTKQAQASSKSPELLARYCDSLLKKSSKNPEEAELEDILNSVMVVFKYIEDKDVFQKFYANMLAKRLVQHNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNDKFKAHLANTGSLDLDFTIQVLSSGSWPFQQ-SWTFSLPAEMEKSHQRFTTFYSSQHSGRKLH 576

HSP 2 Score: 100.523 bits (249), Expect = 1.047e-21
Identity = 66/187 (35.29%), Postives = 105/187 (56.15%), Query Frame = 2

Query: 1979 ITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +T+    RY LQ STYQM +L+ FN    YT +++ ++T +    L + L  L    +  ++L+ +     + L P+ V  +   + +K  ++ +      E   E+ +T   ++E+RK +I+A IVRIMK RK L H  L+AEV  QL SRF P    IK+ I+ L+E++YL R + +K TY YLA
Sbjct:  587 VTNCFKNRYTLQASTYQMGVLLMFNTADSYTVEQIQEQTQLKMELLIQVLGIL----LKTKLLLCDTCEDVSGLEPSSVLKLFFGYKNKKLRVNINVPMKTEQRNEQEQTHKYIEEDRKLLIQAAIVRIMKMRKMLKHQPLLAEVLSQLSSRFKPRVPTIKKCIDILIEKEYLERVEGEKDTYAYLA 769

[Close]

BLAST of Cullin 3 vs. Ensembl Nematostella
Match: EDO49091 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI48])

HSP 1 Score: 182.185 bits (461), Expect = 6.191e-48
Identity = 150/580 (25.86%), Postives = 286/580 (49.31%), Query Frame = 2

Query:  161 PASLN-DQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVL---QKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMD---RVYVAQTEKQ--------------------NVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGV------NSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES---KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN------SRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPAN-NTGVDLYVRVLTTGLWPTQSLNIN-ISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSV 1768
            P  +N D+   KI +TLK A+V ++K   +   + + + + Y + +   +  GEKLY+  K+ + EH++ + + V     +          +++H+          YMD   R   +  +KQ                    ++    L I++ I++    ++E+L  +LL  + K+R GE   ++ + D  +  V  GV       +  +YE +FEK  L ++ E+YR E+   L+EN  S+ YI +V+ RI++E  RAR +L P +  ++++  E  ++ +HI  +     +    M+  ++  +++ MYKLL  +  GL +M   +   + E G+     +    + P  +V  +L +  K + L+ E       F   ++      +N+       S+SPE L+ + D  L++  K + D +++    + I++F+Y+ DKD+F+++Y + LAKRL+   S S D E++MIS+L   CG  +T++L  MF DM+IS  L   + + +  A  N G++  + VL +G WP    +++  S+ +E+      + +FY  K NGR +    +L N E+ +
Sbjct:    5 PGVVNFDETWAKILKTLK-AVVTLEKIERA--VWNDRFSDVYALCVAYPEPLGEKLYSEIKLFLEEHVKSLYQAVSSPDIDIL--------REYHSHWAKYSQGSSYMDLLFRYLNSHLKKQKQDYVEISPYTVTPICPDAIDIGPLALSIWKSIMIE--PLKETLVQHLLAEIRKDRNGEGTQQNVVHDTIKSFV--GVQEYQSKGALSLYESEFEKPLLQETGEYYRREAADLLAENPCSV-YIQKVDVRIQDEDLRARKFLHPVSYSRVIRECEARMVEEHIPYL----QAECRQMVRGEKCADLSRMYKLLKHIPRGLHVMVTELEQHVEETGQNHDTQKFICFQGPFQYVDAMLDVHSKFTKLIDETFHADQAFHASLDKACTTIVNYRHDARKPSKSPELLAKYCDLILKKSNKNLSDSELDEKLGEVIIVFKYIDDKDIFQKFYSKMLAKRLIHNLSISMDAEEAMISRLKHACGYEYTNRLHWMFTDMSISSDLNSSFSDFLATAQVNMGINFSLLVLQSGAWPLGQTSVSPFSIPQELIRPVQMFEQFYNGKFNGRKLAWLQHLSNGEVKL 564

HSP 2 Score: 68.1662 bits (165), Expect = 1.119e-11
Identity = 55/188 (29.26%), Postives = 99/188 (52.66%), Query Frame = 2

Query: 1997 KRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIK----VQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIA---EVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            + Y L VST+QM +++ FN K ++TF EL   T + +++LTR + SL   K+  +   ++  SK         +++N +F+SK  K+K    VQ  + +             D    ++ E  +VR    ++T  ++ L +   +V  Q ++RF+P+  MIK+ IE+L+++ YL R +  K  Y Y+A
Sbjct:  569 RTYFLTVSTFQMAVMLLFNDKLQFTFSELSTLTQLLNKELTRIIQSLVDVKLLNK--TEDDDSKEA------TYSLNMNFSSKRTKLKITSAVQRDSPQVVILLSTRGTADSDNWHLHLAEKPMVRSYHLQQT--NDTLFSFCLQVISQSRARFIPSVPMIKKCIEALIDKQYLDRQEGSKDEYSYVA 746

[Close]

BLAST of Cullin 3 vs. Ensembl Nematostella
Match: EDO38761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC24])

HSP 1 Score: 130.954 bits (328), Expect = 2.815e-31
Identity = 109/438 (24.89%), Postives = 204/438 (46.58%), Query Frame = 2

Query:  563 IRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNST---LIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQG--------RAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLF---RNQINADFEYFINHN------------------------SRSPEYLSLFIDDKLRRGT--KGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLI-VECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGN 1753
            I+  LQS+ + +V  ER GE      +    +  V L  +++   +IY E+FEK ++D ++EFY+ ++ S+L EN +   Y+   E +++EE +RA  YL+       V VL E  ++  +        +    M+   +   +  M++L+ RV  G+  M Q + S++   G          +  D  K    +V +LL L ++ S ++ EA ++   F   R++    F+  +N                          SR PE L+ + D  LR+ T  K +   ++E+     +++ +Y+ +KDVF RY+K HL +RL+   S   + E++M+  L  V     + +KL  MF+D+ +S+ L  ++  + +   +    + +++L  G W   S  I +SL  E++       +FY   H+GR +     + N
Sbjct:  152 IKNRLQSSAMKLVHAERNGEAFDSQLVIGVRESYVNLSSDASDKLMIYRENFEKAYIDATEEFYKAQASSYLQENGVQ-NYMRYAEMKLKEEEQRALRYLETRKGCNSVAVLTECCVNVLVGSFKETILAEGPGMIAANETKKLLLMFQLMDRVKGGVDPMIQSLESYIVTTGLNDMLAAAETITTDSEK----YVEQLLALFNRFSAMVKEAFNDDPRFLTARDKAPQAFKTVVNDTKIFKLELPSKGKGSGALSVKPQPESRCPELLANYCDMLLRKTTYSKKLTSDEIESKLKDVLLVLKYVVNKDVFMRYHKAHLTRRLILDTSADSEMEENMVEWLRDVGMPADYINKLARMFQDIKVSEDLNQEFKRTCRDKGDIADSINIKILNAGAWSRASERIPVSLPTELEDCIPEVEEFYRKNHSGRKLQWHHLMSN 584

HSP 2 Score: 76.2554 bits (186), Expect = 3.676e-14
Identity = 59/195 (30.26%), Postives = 107/195 (54.87%), Query Frame = 2

Query: 1985 SSGIKRYILQVSTYQMVILMKFNKK--SKYTFDELLKETCIPDRDLTRXXXXXXX-XKISQRILVKEPKSKST-DLLPTDVFTINESFTS-KHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYV------IEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYL 2536
            S+   ++ L+V+T+QM +L  +N++     +++ L   T +PD +L ++L S+    K+ ++IL  EP  +S  D   + +F +N+ F   K+ K++ +         +    K + +EN   V      I+  IV+IMK RK +++  L  E+ E LK+ F+P  +MIK++ E L+E  YL R ++D  T+ YL
Sbjct:  590 SNKTGKFDLEVTTFQMSVLFAWNERPLDHISYENLRLATELPDSELRKTLWSMVSIPKLKRQILTCEPAVRSPKDFTDSSMFWVNQDFALIKNGKVQKRGKVNLIGRLQLSTDKAKQEENEGIVALRILRIQEAIVKIMKMRKRITNAALQTELVEILKNMFIPQKKMIKEQTEWLIEHKYLKRDEEDINTFIYL 784

[Close]

BLAST of Cullin 3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875])

HSP 1 Score: 769.229 bits (1985), Expect = 0.000e+0
Identity = 426/807 (52.79%), Postives = 568/807 (70.38%), Query Frame = 2

Query:  140 KMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIK--PANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            KMRI+AFP +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGE+LY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+A QML+ LG++   +YEEDFE  FLD S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHL +RLL+ KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   I+   A+ +GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G  +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN   K+ F+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:   13 KMRIRAFPMTMDEKYVNNIWDLLKSAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNASQMLMILGLDGRSVYEEDFEGPFLDMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNSKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKTRFDHFLIESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLGRRLLSNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHIQTTSASLSGVDLTVRVLTTGYWPTQSATPKCTIPPAPRHAFEVFRRFYLAKHSGRQLTLQHHMGGADLNATFYGAVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766

[Close]

BLAST of Cullin 3 vs. Ensembl Medaka
Match: cul3b (cullin-3 [Source:NCBI gene;Acc:101172920])

HSP 1 Score: 753.821 bits (1945), Expect = 0.000e+0
Identity = 420/798 (52.63%), Postives = 560/798 (70.18%), Query Frame = 2

Query:  167 SLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNT--GVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGEKLY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+ACQML+ LG+    +YEEDFE  FL+ S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+S++LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHLA+RLLT KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   ++    +  GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL KH+GR + LQ ++G+ +L+  FY                             PI           GS++   GG  VTG              S  +++ILQVST+QM ILM FN + K TF+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:    2 TMDEKYVNNIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTDDLACMYKLFSRVPNGLKTMCECMSAYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLGKHSGRQLTLQHHMGSADLNATFYG----------------------------PIKKED-------GSEVV-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--NGHVFTVNDQFTSKLHRVKIQTVVAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746

[Close]

BLAST of Cullin 3 vs. Ensembl Medaka
Match: CUL3 (cullin-3-like [Source:NCBI gene;Acc:101170875])

HSP 1 Score: 753.436 bits (1944), Expect = 0.000e+0
Identity = 419/798 (52.51%), Postives = 560/798 (70.18%), Query Frame = 2

Query:  167 SLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHL-QKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDES--KSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIK--PANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXX--XXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            +++++YV  IW+ LK AI EIQ+KNNSGLSFEELYRNAYTMVL KHGE+LY G + VVTEHL  K++E VL +LNNNFL  LNQ W DH TAMVMIRDILMYMDRVYV Q   +NVYN GLIIFRD V+R   IR+ L+  LL+M+A+ERKGEV+ +  IR+A QML+ LG++   +YEEDFE  FLD S EF+++ES+ FL+EN+ S+ YI +VE RI EE +R  H LD STE  IVKV+E ELISKH+  IV M +SGL +ML   +  ++A MYKL SRV NGL+ M +C+SS+LREQG+A+V +E   K+P+ ++  LL L+ +    L E+ +N  LF+  I  DFEYF+N NSRSPEYLSLFIDDKL++G KG+ + +VE++ DK +VLFR++Q+KDVFERYYKQHL +RLL+ KS SDD EK+MISKL  ECG  FTSKLEGMF+DM+IS   MD++   I+   A+ +GVDL VRVLTTG WPTQS     ++    + AF+ + +FYL+KH+GR + LQ ++G  +L+  FY                         ED               GS++   GG  VTG              S  +++ILQVST+QM ILM FN   K+ F+E+ +ET IP+R+L R+L SL+  K +QR+L KEPKSK  +     VFT+N+ FTSK +++K+Q +  K+ E   ER+ET+ +VD++RK+ IEA IVRIMK+RK + HN+L+AEVT+QL++RF+P+P +IK+RIE L+ER+YLAR+ +D+K Y Y+A
Sbjct:    2 TMDEKYVNNIWDLLKSAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGERLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNASQMLMILGLDGRSVYEEDFEGPFLDMSAEFFQMESQKFLAENSASV-YIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNSKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKTRFDHFLIESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLGRRLLSNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHIQTTSASLSGVDLTVRVLTTGYWPTQSATPKCTIPPAPRHAFEVFRRFYLAKHSGRQLTLQHHMGGADLNATFYGAVKK--------------------ED---------------GSEVG-VGGAQVTG--------------SNTRKHILQVSTFQMTILMLFNNIDKFNFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIE--SGHVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 746

[Close]

BLAST of Cullin 3 vs. Ensembl Medaka
Match: cul4b (cullin 4B [Source:NCBI gene;Acc:101161413])

HSP 1 Score: 289.656 bits (740), Expect = 8.674e-85
Identity = 184/567 (32.45%), Postives = 309/567 (54.50%), Query Frame = 2

Query:   92 SSNTRKFEASLSSNSNKMRIKAF--PASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXX--QCWKDHHTAMVMIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            ++ +  F +S    + K+ IK F     L + Y  + W+ LK+A+  IQ   +   + EELY+    +   K   KLY   +    +H++   +Q  E+  ++ L      +CW+DH   M+MIR I +++DR YV Q     ++++ GL +FR  ++ +++++    + +L ++ +ER GE I +S +R    M     ++   IY++ FE+ FL+++   Y  E +  + E  +   Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+   +     GL  +L+E +  +++ +Y+L SRV  G+Q++ Q    +++  G  +V++  K     V ELL  +DK   ++      +  F N +   FE FIN     P E ++  +D KLR G K   D ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +        N  ++L V +LT G WPT  + + + L  E+    + +  FYL KH+GR +  Q  LG+  L   F
Sbjct:  130 TAGSGTFSSSKPGAAKKLVIKNFREKPKLPENYTQETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCFHKVSAKLYKQLRAACEDHIKAQIDQFREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRFYIISDLKVQSKTINGILLLIERERNGEAIDRSLLRSLLSM-----LSDLQIYQDSFEQRFLEETNRLYAAEGQRLMQEREVP-EYLHHVSKRLEEEADRVITYLDQSTQKPLIATVEKQLLGEHLTATL---QKGLTQLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK-TMVQELLDFKDKVDHIMDVCFIRNEKFVNAMKEAFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQCQNIPGN--IELTVNILTMGYWPT-YVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF 683

HSP 2 Score: 90.5077 bits (223), Expect = 3.562e-18
Identity = 65/140 (46.43%), Postives = 92/140 (65.71%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLK 2428
            LQVS +Q ++L+ FN+  +++ +E+   T I D +L R+L SL+  K   R+L K PKSK  D+   D F+ N  F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A IVRIMK RKTLSHNLL++EV  QLK
Sbjct:  690 LQVSLFQTLVLLMFNEGEEFSLEEIKLATGIEDGELRRTLQSLACGKA--RVLTKTPKSK--DVEDGDKFSCNNDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLMSEVYNQLK 825

[Close]

BLAST of Cullin 3 vs. Ensembl Medaka
Match: cul4a (cullin-4A [Source:NCBI gene;Acc:101154851])

HSP 1 Score: 254.603 bits (649), Expect = 6.268e-74
Identity = 156/449 (34.74%), Postives = 248/449 (55.23%), Query Frame = 2

Query:  446 MIRDILMYMDRVYVAQTEK-QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDW----LNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLF 1774
            MIR I +++DR YV Q     ++++TGL +FR  ++ +  +++     +L  +  ER GE + +S +R    ML  L V     Y++ FE+ FL ++   Y       L +      Y++ V +R+EEE+ R   YLD ST+  ++  +E++L+ +H+  I+     GL+ +L+E + T +A +Y+L S+V  GL  + Q    +++  G  +V    K     V +LL  +DK   +       +  F N +   FE FIN     P E ++ ++D KLR G K   + ++E + DK +++FR++  KDVFE +YK+ LAKRLL  KS S D EKSM+SKL  ECG  FTSKLEGMFKDM +SK +M  +     N  +P+N   ++L V +LT G WP+ +  + + L  E+    + +  FYL KH+GR +  QP LG+  L   F
Sbjct:    1 MIRSIFLFLDRTYVLQNSLLPSIWDTGLELFRTHIVSDSAVQKRTVEAILEQIELERNGETVDRSLLRSLLGMLSDLQV-----YKDSFEERFLAETDRLY-AAEGQRLMQERDVPEYLHHVARRLEEENDRILSYLDQSTQKPLICCVEKQLLGEHMTAIL---QKGLSNLLDENRVTELALLYQLFSKVKGGLPTLLQFWRDYIKSFGGEIVCTPEKDK-DMVQDLLDFKDKMDNVAQSCFGRNEGFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATEEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQHMQNQSEPSN---IELTVNILTMGYWPSYT-PMEVHLPAEMVKLQEVFKLFYLGKHSGRKLQWQPTLGHAVLKAEF 435

HSP 2 Score: 108.997 bits (271), Expect = 3.727e-24
Identity = 75/177 (42.37%), Postives = 112/177 (63.28%), Query Frame = 2

Query: 2009 LQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            LQVS +Q ++L+ FN+  +++ +E+   T I + +L R+L SL+  K   R+L K P+ K  D+   D F  N  F  K ++IK+  I +KET  E+  T  RV ++R+Y I+A +VRIMK RKTLSHNLL++E+  QLK  F   P  +K+RIESL++RDY+ R  +    Y Y+A
Sbjct:  442 LQVSLFQTLVLLMFNEGEEFSVEEIRAATGIEEGELKRTLQSLACGKA--RVLNKNPRGK--DVEDGDRFNFNSDFKHKLFRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAVVRIMKMRKTLSHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKETPNQYHYVA 612

[Close]

BLAST of Cullin 3 vs. Planmine SMEST
Match: SMESG000033325.1 (SMESG000033325.1)

HSP 1 Score: 1395.95 bits (3612), Expect = 0.000e+0
Identity = 748/752 (99.47%), Postives = 749/752 (99.60%), Query Frame = 2

Query:   89 MSSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVI 2344
            MSSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVLENLNNNFLNYLNQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRLESESFLSENNLSIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNSIPLPLVGSPSSSST GNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRSLLSLSLSKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNITIKETEPERRETKTRVDENRK  +
Sbjct:    1 MSSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVLENLNNNFLNYLNQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRLESESFLSENNLSIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNSIPLPLVGSPSSSSTTGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRSLLSLSLSKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNITIKETEPERRETKTRVDENRKLCL 752

[Close]

BLAST of Cullin 3 vs. Planmine SMEST
Match: SMESG000001134.1 (SMESG000001134.1)

HSP 1 Score: 991.49 bits (2562), Expect = 0.000e+0
Identity = 530/819 (64.71%), Postives = 657/819 (80.22%), Query Frame = 2

Query:   89 MSSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKKNNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIK--PANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKISQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            MS N RK ++S+SSN +KMRIKAFP S++DQ V KIWE LK+AI+EIQKKNNSGLSFEELYRNAYTMVLQK+GE+LYNGTK VVT+H+ KI+++VLE L NNFL +LN+CWKDH TAMVMIRDILMYMDRVYV  T+K NVYNTG+IIFRD VLR+  IR  L+  LL+MV +ER GEVI++ Q+RDACQML QLGV+   IYEEDFE  FL+QS++FYR ESE  L+EN  + +YI +V + IE+E+KRAR +L+ +TE KIV+VL EELI  HI+ +VN  + GL +ML+ K+++ IA M+ LL RVDNGL  MS CIS FLRE+GR +V D+ K+P  ++ EL+ LRD+A+ LL  AL N+ LF+NQIN+DFE+FIN NSRSPEYLSL+IDDKL+RGTKG+ D D++A+FDKCI+LFRYLQDKD+FERYYKQHLAKRLL  KSQSDDQEKSMISKL++ECGGVFTSKLEGMFKDMAISK LM+++ + ++    N  G+DL+VRVLTTGLWPTQ+    + + +E Q+AF  Y++FYL KHNGRVINLQPNLGNVEL+  +  + P+          S ++T G         V+    + G   SQI         G+  +S NS  G TS  I+++ILQVSTYQM+ILMKFN+KSKY+++EL++ET IP+RDLTR L+SLSLSK +QRIL+KEPK+K+T+ + TD F+INESFTSKH KIK+Q+I +KETEPE +ETK +VDENRKYVIEATIVRIMKARK+L+HNLL+AEV EQLKSRF+PTPQMIKQRIESLLERDYLARSDDD+K Y YLA
Sbjct:    1 MSGNIRKLDSSVSSNPSKMRIKAFPTSMSDQSVSKIWECLKRAIIEIQKKNNSGLSFEELYRNAYTMVLQKNGEQLYNGTKAVVTDHMIKIRDEVLERLTNNFLAFLNRCWKDHITAMVMIRDILMYMDRVYVTTTDKPNVYNTGMIIFRDTVLRHEAIRRHLRVTLLDMVKRERHGEVISRLQLRDACQMLAQLGVDKLNIYEEDFENYFLEQSRDFYRSESERLLTENASN-LYITQVNKIIEDEAKRARDFLNSTTEAKIVQVLNEELIKNHIESVVNTENFGLTHMLSNKKYSEIALMFNLLKRVDNGLATMSSCISRFLREEGRKIVEDD-KTPQIYIQELIYLRDRANDLLLNALLNNQLFKNQINSDFEFFINQNSRSPEYLSLYIDDKLKRGTKGISDQDIDAIFDKCIILFRYLQDKDIFERYYKQHLAKRLLMSKSQSDDQEKSMISKLLIECGGVFTSKLEGMFKDMAISKTLMEEFHSQLQMYTTNTLGIDLFVRVLTTGLWPTQTATQTVCMPDEAQNAFSIYSRFYLGKHNGRVINLQPNLGNVELTAYYMQSQPS-------TFQSLTATDG---------VSEPNFNQGYQSSQI--------VGDVGASFNSFSGSTSQSIRKFILQVSTYQMIILMKFNRKSKYSYEELVEETKIPERDLTRCLISLSLSKSTQRILLKEPKNKNTEFIATDTFSINESFTSKHIKIKIQSIAVKETEPEVKETKNKVDENRKYVIEATIVRIMKARKSLAHNLLVAEVIEQLKSRFVPTPQMIKQRIESLLERDYLARSDDDRKVYHYLA 793

[Close]

BLAST of Cullin 3 vs. Planmine SMEST
Match: SMESG000008644.1 (SMESG000008644.1)

HSP 1 Score: 199.904 bits (507), Expect = 2.848e-53
Identity = 203/820 (24.76%), Postives = 365/820 (44.51%), Query Frame = 2

Query:  305 GEKLYNGTKVVVTEHLQKIKEQVXXXXXXXXXXXXXQCWKDHHTAMVMIRDILMYMDRVYV------AQTEKQNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGV-------------------NSTLIYEED-----------------FEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVK----VLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVV----VDESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNS---------RSPEYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLGNVELSVLFYSTAPNXXXXXXXXXXXXXXTAGNLPEDIFPIVAPSRDSSGSFGSQISHTGGDAVTGNRASSVNSHLG----ITSSGIKRYILQVSTYQMVILMKFNKKSKYTFDELLKETCIPDRDLTRXXXXXXXXKI------------SQRILVKEPKSKSTDLLPTDVFTINESFTSKHYKIKVQNXXXXXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            G +LY   K  +  H+ K+K +     +   L ++   W ++  ++ ++  + MY++R +V         +  ++Y   L+ + + +LR  +    +   L+  V KER  E +    ++     LV++G                    NSTLI + D                 FE  F+ +++ FYR+ES  FL++N ++  Y+ +VE R+ EE +R   ++  +   K ++    VL + L++ H+D I+N        +L  ++ +++  M+ LL ++      M+    +F+ ++G   +     D    P  ++  +L +  K    +TEA      F   ++   E FIN N+         ++PE+L+ + D  L++ ++  +  D++ +  + + +F+Y++DKDVF+ +Y + LA+RL+   S S+D E +MIS+L   CG  +T+KL+ MF D + S+                                                 D  AKF +S  N          GN++L+V+  S+            P ++     LP+++ P      D   +     +HTG       R  S   +LG    +T    K YI QVSTYQ+ IL+ FNK   Y+  E+++ T +    + + L      K+              +I       +  D+ P  V  +   + +K  ++ +      ET+ E  E  +RVD +R+  I+A IVR+MK RKTL H  L+ EV EQL ++F P   +IK+ I  L+E++YL R  + K TY+YLA
Sbjct:   88 GWELYKKLKEYLKNHVIKLKIKGDGKTDEEMLKFIQSSWTEYSFSVKVLNGVCMYLNRNWVKRQLEEGHKQFHDIYTCALLAWTENLLRPHQT--IISDALIKEVEKERLDEQLNHRFLKPIIDCLVEVGRVGGSTPKITGTLGQSQHSDNSTLIGQADHDVSMKMNFDLSVYVKIFETPFIKKTERFYRIESMDFLAKNEITD-YLKKVEDRMAEEEQRINSFIHFAPRNKTLEELNSVLTKTLLADHLDRIIN----EFTPLLAAERISDLRRMFTLLYKIPEAFISMTSHFENFVYQKGNEAISSKSTDNLPEPKVYIETILDVYKKNYATVTEAFHGEIRFLKALDKGCERFINKNAVTEMAKTSRKTPEFLAKYCDMLLKKSSRDTNTDDLDEILSRFMTVFKYIEDKDVFQGFYSKMLARRLINDLSISEDIEAAMISRLKESCGYEYTAKLQRMFSDKSTSR-------------------------------------------------DLNAKFLISPQNKS--------GNIDLNVMVLSS---------NSWPYTAQEKFTLPQELIPCYQSFIDFFNT-----AHTG-------RKLSWCFNLGRGEVVTHYTKKTYIFQVSTYQIAILLLFNKCLSYSVKEIVEATQLESNIVIQILQIFLRGKVLVVNGDKMVMDTVSKIDTNLENEEIPDIGPNTVMHLYTDYRNKRIRVNLNLQLKGETKQEVEEVISRVDHDRRMAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVTLIKRCIAGLIEKEYLKRDSNCKDTYQYLA 822

[Close]

BLAST of Cullin 3 vs. Planmine SMEST
Match: SMESG000054773.1 (SMESG000054773.1)

HSP 1 Score: 147.132 bits (370), Expect = 8.639e-37
Identity = 120/434 (27.65%), Postives = 212/434 (48.85%), Query Frame = 2

Query:  503 QNVYNTGLIIFRDIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTLIYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLD-PSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDN------GLQMMSQCISSFLREQGRAVVV---DESKSPIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHNSRSP-EYLSLFIDDKLRRGTKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNS-------IKPANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQPNLG 1750
            +++Y TG +I ++IVL             L  +  +R G     S  +   QM + L      +Y+  +E  +LD+++ +Y  ESE  L E + +  Y+  V  R++EE++R++ YL   S   ++   L   ++  H+DE++    SG N+M+       +  +Y L   +++      G+ ++      ++ + G  +V    D+ +         L L+    +++ +       F   I   FE F+N     P EYL+ F+D KLR G K + +  +E + DK + LFR++  KDVFE +Y + LAKRLL  KS   D EK+M+ KL  ECG  +T K+E MF D+  S+ L   + +S        K  N   +++ V V+    WP+   +  +++ + +    +A++ FY   HNGR +  +P+LG
Sbjct:   27 RDMYITGPLINKEIVL------------CLKQIHNQRDGISSDLSLSKAVAQMFIDLD-----LYQRFWEPKYLDEARSYYSQESERKLKELSNTD-YLVYVNTRLDEENERSQMYLSGDSIRIQLRDQLVNIILKPHLDELL---KSGFNHMMENNDIFYLELLYNLAQLLNSKSADSSGIYILRNYFKEYVMKSGTLIVENPNDDVEKDKKMTQNFLDLKVHLDSVVEKCFKGDMSFYKTIRDCFEAFLNARPNKPAEYLAKFLDSKLRSGNKNLTEEAMELIMDKVMTLFRFITGKDVFEAFYLKDLAKRLLMGKSACVDTEKAMLEKLKHECGPNYTRKMEIMFSDIDNSQRLSKQFSDSNSLQNIIDKDMNKVNIEMNVNVICNATWPSLGGSKLLNIPQYMIDMQNAFSAFYKRDHNGRKLRFEPSLG 439

[Close]

BLAST of Cullin 3 vs. Planmine SMEST
Match: SMESG000020142.1 (SMESG000020142.1)

HSP 1 Score: 147.517 bits (371), Expect = 3.148e-36
Identity = 115/421 (27.32%), Postives = 206/421 (48.93%), Query Frame = 2

Query:  560 EIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNSTL---IYEEDFEKVFLDQSKEFYRXXXXXXXXXXXXXIMYINRVEQRIEEESKRARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIASMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKS----PIAFVTELLTLRDKASTLLTEALDNHSLFRNQINADFEYFINHN--------------------SRSPEYLSLFIDDKLRRG--TKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDDQEKSMISKLI-VECGGVFTSKLEGMFKDMAISKILMDDWLNSIK-PANNTGVDLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVI 1729
            +I   LQ++ + +V  ER G VI    +    +  V L   +     IY+E+FEK +L+ +++FYR E+  +L+++ +   Y+  V+Q++EEES RA  YL+ S E + VK LE++ +   I     +  +    M+     + ++ MY LL RV NG+  M   +   ++  G   +++ + S    P  +V  LL + ++ + L+  A      F    +  F++ +N                      SR PE L+ + D  LR+G   + +    VE      I+L +Y+ +KDVF  +YK HL +RLL   S  ++ E++M+ KL  V       +KL  MF+D+ + K L  ++ ++++    N    + +++L  G W  Q L + ++L  E++       +FY  KH GR+I
Sbjct:  146 QINHKLQASAMKLVLDERNGVVIDSQLVIGVRESYVNLSTKAESKLSIYQENFEKAYLEHTEQFYRREASQYLTDHGV-CEYMAWVKQKLEEESNRAHKYLETSQESESVKNLEKKCVEIMIMSFTEIILAEFPSMIKANDTSKLSLMYDLLKRVPNGINPMLDLLEDHIKHSGLNDMMENADSIVSAPEKYVNSLLDMFERFTKLIELAFYTDPEFLTARDKAFQFIVNDTSIFKLDIATSNKPGSVKKPESRCPELLASYCDMLLRKGPTNRRLTTEQVEQRLQCVILLLKYVTNKDVFLGHYKPHLTRRLLLENSADNELEENMVEKLRDVGVPADMVNKLSRMFQDIKVCKDLNAEFKDALRNNRENVAEIVNIKILNGGAWMQQGLRVPLTLPRELEDYIPEVEEFYRKKHQGRMI 565

HSP 2 Score: 67.3958 bits (163), Expect = 3.621e-11
Identity = 61/193 (31.61%), Postives = 108/193 (55.96%), Query Frame = 2

Query: 2000 RYILQVSTYQMVILMKFNKK--SKYTFDELLKETCIPDRDLTRXXXXXXXX-KISQRILVKEPKSKSTDLLPTDV-FTINESFTSKHYKIKVQNXXX---------XXXXXXXXXXXXXVDENRKYVIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLERDYLARSDDDKKTYRYLA 2539
            ++ L V+T+QM IL  +N +   + + + L   T +   DL R+L SLS   K+ +++LV EPK+KS +    +  F IN  F S   + KVQN               +  + + ++ + E RKY ++  I++IMK+R+ + H  L +E+ E L++ F P+ ++IK+ IE L+E +Y+ R  +D  ++ Y+A
Sbjct:  584 KFDLDVTTFQMAILFSWNSRPFDRLSLESLQMATGLAMGDLKRNLWSLSEHGKLDKQLLVYEPKAKSAEEFTENTEFWINHDF-SLIKQGKVQNRGRLNLIGRMPLTLDKKTQEQDESAIVELRKYRVQEGIIKIMKSRRQMRHIELCSELLELLRNLFQPSQRLIKEVIEWLIEEEYIKRDANDLSSFLYIA 775

The following BLAST results are available for this feature:

BLAST of Cullin 3 vs. Ensembl Human
BLAST of Cullin 3 vs. Ensembl Celegans
BLAST of Cullin 3 vs. Ensembl Fly
BLAST of Cullin 3 vs. Ensembl Zebrafish
BLAST of Cullin 3 vs. Ensembl Xenopus
BLAST of Cullin 3 vs. Ensembl Mouse
BLAST of Cullin 3 vs. UniProt/SwissProt
BLAST of Cullin 3 vs. TrEMBL
BLAST of Cullin 3 vs. Ensembl Cavefish
BLAST of Cullin 3 vs. Ensembl Sea Lamprey
BLAST of Cullin 3 vs. Ensembl Yeast
BLAST of Cullin 3 vs. Ensembl Nematostella
BLAST of Cullin 3 vs. Ensembl Medaka
BLAST of Cullin 3 vs. Planmine SMEST

BLAST of Cullin 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CUL3	0.000e+0	52.83	cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]	[more]
CUL3	0.000e+0	52.82	cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]	[more]
CUL3	0.000e+0	52.82	cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]	[more]
CUL3	0.000e+0	50.91	cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]	[more]
CUL4A	2.378e-89	34.12	cullin 4A [Source:HGNC Symbol;Acc:HGNC:2554]	[more]

BLAST of Cullin 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cul-3	0.000e+0	40.95	Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]	[more]
cul-3	0.000e+0	40.95	Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]	[more]
cul-3	0.000e+0	40.95	Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]	[more]
cul-3	1.123e-167	39.24	Cullin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q17391]	[more]
cul-2	1.195e-52	24.16	Cullin-2 [Source:UniProtKB/Swiss-Prot;Acc:Q17390]	[more]

BLAST of Cullin 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cul3	0.000e+0	51.36	gene:FBgn0261268 transcript:FBtr0302158	[more]
Cul3	0.000e+0	51.36	gene:FBgn0261268 transcript:FBtr0302157	[more]
Cul3	0.000e+0	51.36	gene:FBgn0261268 transcript:FBtr0302156	[more]
Cul3	0.000e+0	51.37	gene:FBgn0261268 transcript:FBtr0302159	[more]
Cul4	2.838e-92	35.43	gene:FBgn0033260 transcript:FBtr0301355	[more]

BLAST of Cullin 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cul3b	0.000e+0	52.79	cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1]	[more]
cul3a	0.000e+0	52.54	cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376]	[more]
cul3b	0.000e+0	58.59	cullin 3b [Source:ZFIN;Acc:ZDB-GENE-081007-1]	[more]
cul4b	4.916e-88	32.92	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul4b	6.284e-88	32.92	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]

BLAST of Cullin 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cul3	0.000e+0	52.83	cullin 3 [Source:NCBI gene;Acc:548729]	[more]
cul3	0.000e+0	52.76	cullin 3 [Source:NCBI gene;Acc:548729]	[more]
cul3	0.000e+0	52.76	cullin 3 [Source:NCBI gene;Acc:548729]	[more]
cul3	0.000e+0	50.91	cullin 3 [Source:NCBI gene;Acc:548729]	[more]
cul4a	3.268e-88	34.23	cullin 4A [Source:NCBI gene;Acc:548647]	[more]

BLAST of Cullin 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cul3	0.000e+0	52.83	cullin 3 [Source:MGI Symbol;Acc:MGI:1347360]	[more]
Cul3	0.000e+0	50.91	cullin 3 [Source:MGI Symbol;Acc:MGI:1347360]	[more]
Cul4a	4.536e-84	33.75	cullin 4A [Source:MGI Symbol;Acc:MGI:1914487]	[more]
Cul4b	1.212e-83	32.22	cullin 4B [Source:MGI Symbol;Acc:MGI:1919834]	[more]
Cul4b	5.770e-83	32.04	cullin 4B [Source:MGI Symbol;Acc:MGI:1919834]	[more]

BLAST of Cullin 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|B5DF89\|CUL3_RAT	0.000e+0	52.96	Cullin-3 OS=Rattus norvegicus OX=10116 GN=Cul3 PE=...	[more]
sp\|Q9JLV5\|CUL3_MOUSE	0.000e+0	52.83	Cullin-3 OS=Mus musculus OX=10090 GN=Cul3 PE=1 SV=...	[more]
sp\|Q13618\|CUL3_HUMAN	0.000e+0	52.83	Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2	[more]
sp\|Q6GPF3\|CUL3B_XENLA	0.000e+0	52.83	Cullin-3-B OS=Xenopus laevis OX=8355 GN=cul3b PE=1...	[more]
sp\|A4IHP4\|CUL3_XENTR	0.000e+0	52.83	Cullin-3 OS=Xenopus tropicalis OX=8364 GN=cul3 PE=...	[more]

BLAST of Cullin 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A183SVC2	0.000e+0	60.24	Cullin-3 OS=Schistocephalus solidus OX=70667 GN=SS...	[more]
A0A0X3PL62	0.000e+0	60.24	Cullin-3 (Fragment) OS=Schistocephalus solidus OX=...	[more]
A0A5J4NTB7	0.000e+0	60.32	Cullin 3 OS=Paragonimus westermani OX=34504 GN=DEA...	[more]
C1LH18	0.000e+0	59.44	Cullin-3 OS=Schistosoma japonicum OX=6182 GN=CUL3 ...	[more]
G4VPI9	0.000e+0	60.45	Putative cullin OS=Schistosoma mansoni OX=6183 GN=...	[more]

BLAST of Cullin 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cul3b	0.000e+0	53.04	cullin 3 [Source:NCBI gene;Acc:103024283]	[more]
cul3a	0.000e+0	52.79	cullin 3a [Source:ZFIN;Acc:ZDB-GENE-030131-3376]	[more]
cul4b	1.600e-86	32.45	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul4a	2.327e-75	35.19	cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357]	[more]
ENSAMXT00000057183.1	5.589e-69	34.22	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of Cullin 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cul4b	8.000e-87	33.87	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul1b	1.644e-58	26.57	cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887]	[more]
cul1b	3.836e-58	27.40	cullin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2887]	[more]
cul2	1.198e-41	30.70	cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032]	[more]
cul5a	8.263e-8	21.93	cullin 5a [Source:ZFIN;Acc:ZDB-GENE-030131-5426]	[more]

BLAST of Cullin 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
CDC53	2.766e-32	24.35	Cullin; structural protein of SCF complexes (which...	[more]
CUL3	5.047e-27	25.63	Ubiquitin-protein ligase; forms a complex with Elc...	[more]

BLAST of Cullin 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO35230	0.000e+0	51.12	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35660	4.253e-70	36.11	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37570	5.189e-57	25.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49091	6.191e-48	25.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38761	2.815e-31	24.89	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Cullin 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CUL3	0.000e+0	52.79	cullin-3-like [Source:NCBI gene;Acc:101170875]	[more]
cul3b	0.000e+0	52.63	cullin-3 [Source:NCBI gene;Acc:101172920]	[more]
CUL3	0.000e+0	52.51	cullin-3-like [Source:NCBI gene;Acc:101170875]	[more]
cul4b	8.674e-85	32.45	cullin 4B [Source:NCBI gene;Acc:101161413]	[more]
cul4a	6.268e-74	34.74	cullin-4A [Source:NCBI gene;Acc:101154851]	[more]

BLAST of Cullin 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000033325.1	0.000e+0	99.47	SMESG000033325.1	[more]
SMESG000001134.1	0.000e+0	64.71	SMESG000001134.1	[more]
SMESG000008644.1	2.848e-53	24.76	SMESG000008644.1	[more]
SMESG000054773.1	8.639e-37	27.65	SMESG000054773.1	[more]
SMESG000020142.1	3.148e-36	27.32	SMESG000020142.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30005732 ID=SMED30005732|Name=Cullin 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2561bp
CTAAATTGCGATTGATTTTGTTGCTATATATTTTAAAAATCATTTTGGCA
ACAAATTTCAGGCGCTCTTGATGAATGATTGATTTTAAATGTCTTCAAAT
ACACGCAAATTTGAAGCATCTTTATCTTCAAACTCGAATAAAATGCGAAT
TAAAGCATTCCCAGCTTCTTTAAATGATCAGTATGTCGGGAAAATTTGGG
AAACATTGAAAAAAGCAATTGTAGAAATTCAAAAAAAGAATAACAGTGGA
TTAAGTTTTGAAGAATTGTATCGAAATGCCTATACAATGGTGCTACAAAA
ACATGGTGAGAAATTGTATAATGGAACTAAGGTAGTTGTTACAGAACATT
TGCAGAAAATTAAAGAACAAGTTTTGGAAAATTTAAATAATAATTTTCTT
AATTATTTGAATCAATGTTGGAAAGATCATCATACAGCAATGGTAATGAT
TAGAGACATTTTAATGTATATGGATAGAGTTTATGTTGCTCAAACTGAAA
AGCAAAATGTGTATAACACTGGACTGATTATATTTCGAGATATAGTTCTA
AGAAATGTAGAAATTAGGGAAAGCTTACAGTCGAATCTATTAAATATGGT
TGCAAAAGAAAGAAAAGGTGAAGTTATAGCGAAATCGCAAATTAGAGATG
CGTGTCAAATGTTAGTTCAGCTAGGAGTTAATTCTACACTTATTTATGAA
GAAGACTTTGAGAAAGTATTTTTAGATCAATCAAAAGAATTTTACAGGCT
GGAAAGTGAGAGTTTTTTGAGCGAGAATAATTTATCCATAATGTATATAA
ATCGTGTTGAACAACGAATTGAAGAAGAATCGAAGCGAGCTAGACATTAC
TTGGATCCATCAACCGAACCTAAAATAGTAAAGGTTTTAGAGGAAGAATT
GATTAGTAAACACATCGATGAAATCGTAAATATGTCGCATTCAGGATTAA
ATTATATGCTAAACGAAAAACAGCATACAAATATTGCTTCCATGTATAAA
TTGTTATCAAGAGTAGATAATGGCTTGCAAATGATGAGTCAATGCATTAG
CTCATTCTTACGGGAACAAGGTCGTGCTGTTGTCGTTGACGAATCTAAAT
CTCCTATCGCGTTCGTCACTGAACTTTTAACTTTGCGTGATAAAGCTTCA
ACCCTTCTCACAGAAGCGTTAGATAATCATTCATTATTCCGAAATCAAAT
CAATGCTGATTTTGAATATTTTATCAACCACAACAGTCGCTCACCTGAAT
ATCTTTCTCTTTTTATTGACGATAAACTCCGACGAGGTACTAAAGGCATG
GATGACCCAGATGTTGAAGCCGTATTTGATAAATGCATCGTTTTGTTTCG
TTATTTACAAGATAAAGATGTTTTTGAACGTTATTACAAACAGCATTTAG
CGAAAAGATTATTAACAATGAAAAGTCAATCAGATGATCAAGAGAAAAGC
ATGATCTCAAAATTAATTGTTGAATGTGGCGGGGTTTTTACTAGTAAACT
AGAAGGAATGTTTAAAGACATGGCAATTTCTAAAATACTTATGGATGATT
GGCTAAATTCAATTAAGCCTGCTAATAATACTGGTGTTGACTTGTATGTT
CGAGTTCTCACTACCGGTTTATGGCCAACCCAGTCGCTTAATATTAATAT
TTCTTTATCAGAAGAAGTACAGTCAGCATTTGATGCTTATGCCAAATTCT
ATTTAAGCAAACATAACGGTCGTGTTATCAATTTACAACCAAATTTAGGA
AATGTTGAACTTTCTGTTCTATTTTATTCCACTGCACCTAACTCAATTCC
CTTGCCTCTTGTGGGTTCTCCCTCAAGTAGTTCTACCGCCGGTAATCTGC
CAGAAGATATCTTTCCGATTGTTGCTCCATCTAGAGACAGTAGTGGAAGT
TTTGGTAGTCAGATTAGCCATACAGGCGGAGATGCTGTTACAGGAAATAG
AGCATCCAGTGTCAACAGTCATTTAGGAATAACATCTTCAGGCATAAAAA
GATACATACTTCAAGTTTCAACCTATCAGATGGTGATTTTAATGAAATTC
AACAAGAAATCTAAATATACATTTGATGAATTATTGAAAGAAACATGCAT
TCCTGATAGAGATTTGACGCGTTCATTGTTGTCATTATCACTCAGCAAAA
TATCTCAGAGAATTCTAGTCAAAGAGCCTAAATCAAAATCCACAGACCTG
TTACCAACCGATGTTTTTACTATTAATGAGTCATTTACTTCCAAGCACTA
TAAAATAAAAGTACAAAATATAACAATTAAGGAAACTGAACCAGAAAGAC
GAGAAACCAAAACCAGAGTAGATGAAAATCGTAAGTATGTAATTGAAGCC
ACAATAGTTAGAATAATGAAAGCAAGGAAAACTTTGTCTCATAACCTATT
AATAGCAGAAGTAACAGAACAATTAAAATCTCGGTTTATGCCAACGCCTC
AGATGATAAAACAACGAATTGAGTCTCTCCTTGAACGTGATTATTTGGCC
AGATCAGATGACGATAAGAAAACTTACCGTTATTTAGCTTGATGTTTTTT
TTCAAATCTTG

protein sequence of SMED30005732-orf-1

>SMED30005732-orf-1 ID=SMED30005732-orf-1|Name=SMED30005732-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=818bp
MSSNTRKFEASLSSNSNKMRIKAFPASLNDQYVGKIWETLKKAIVEIQKK
NNSGLSFEELYRNAYTMVLQKHGEKLYNGTKVVVTEHLQKIKEQVLENLN
NNFLNYLNQCWKDHHTAMVMIRDILMYMDRVYVAQTEKQNVYNTGLIIFR
DIVLRNVEIRESLQSNLLNMVAKERKGEVIAKSQIRDACQMLVQLGVNST
LIYEEDFEKVFLDQSKEFYRLESESFLSENNLSIMYINRVEQRIEEESKR
ARHYLDPSTEPKIVKVLEEELISKHIDEIVNMSHSGLNYMLNEKQHTNIA
SMYKLLSRVDNGLQMMSQCISSFLREQGRAVVVDESKSPIAFVTELLTLR
DKASTLLTEALDNHSLFRNQINADFEYFINHNSRSPEYLSLFIDDKLRRG
TKGMDDPDVEAVFDKCIVLFRYLQDKDVFERYYKQHLAKRLLTMKSQSDD
QEKSMISKLIVECGGVFTSKLEGMFKDMAISKILMDDWLNSIKPANNTGV
DLYVRVLTTGLWPTQSLNINISLSEEVQSAFDAYAKFYLSKHNGRVINLQ
PNLGNVELSVLFYSTAPNSIPLPLVGSPSSSSTAGNLPEDIFPIVAPSRD
SSGSFGSQISHTGGDAVTGNRASSVNSHLGITSSGIKRYILQVSTYQMVI
LMKFNKKSKYTFDELLKETCIPDRDLTRSLLSLSLSKISQRILVKEPKSK
STDLLPTDVFTINESFTSKHYKIKVQNITIKETEPERRETKTRVDENRKY
VIEATIVRIMKARKTLSHNLLIAEVTEQLKSRFMPTPQMIKQRIESLLER
DYLARSDDDKKTYRYLA*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000136	whole organism

Vocabulary: **INTERPRO**
Term	Definition
IPR036388	WH-like_DNA-bd_sf
IPR036390	WH_DNA-bd_sf
IPR036317	Cullin_homology_sf
IPR016158	Cullin_homology
IPR019559	Cullin_neddylation_domain
IPR011991	WHTH_DNA-bd_dom
IPR001373	Cullin_N
IPR016157	Cullin_CS
IPR016159	Cullin_repeat-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0031625	ubiquitin protein ligase binding

Vocabulary: **biological process**
Term	Definition
GO:0006511	ubiquitin-dependent protein catabolic process

Vocabulary: **cellular component**
Term	Definition
GO:0031461	cullin-RING ubiquitin ligase complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR016158	Cullin homology domain	SMART	SM00182	cul_2	coord: 414..562 e-value: 4.2E-62 score: 222.3
IPR016158	Cullin homology domain	PROSITE	PS50069	CULLIN_2	coord: 384..684 score: 46.912
IPR019559	Cullin protein, neddylation domain	SMART	SM00884	Cullin_Nedd8_2	coord: 744..811 e-value: 3.5E-37 score: 139.5
IPR019559	Cullin protein, neddylation domain	PFAM	PF10557	Cullin_Nedd8	coord: 747..809 e-value: 4.5E-28 score: 97.1
None	No IPR available	GENE3D	G3DSA:1.20.1310.10		coord: 153..276 e-value: 1.1E-38 score: 133.7
None	No IPR available	GENE3D	G3DSA:1.20.1310.10		coord: 383..495 e-value: 6.0E-39 score: 134.7
None	No IPR available	GENE3D	G3DSA:1.10.10.2620		coord: 624..729 e-value: 1.5E-21 score: 78.6
None	No IPR available	GENE3D	G3DSA:1.20.1310.10		coord: 277..382 e-value: 4.8E-27 score: 96.2
None	No IPR available	GENE3D	G3DSA:1.20.1310.10		coord: 22..151 e-value: 5.7E-44 score: 151.8
None	No IPR available	GENE3D	G3DSA:1.10.10.2620		coord: 498..570 e-value: 1.1E-14 score: 56.4
None	No IPR available	PANTHER	PTHR11932:SF126	CULLIN-3	coord: 31..817
None	No IPR available	PANTHER	PTHR11932	CULLIN	coord: 31..817
IPR001373	Cullin, N-terminal	PFAM	PF00888	Cullin	coord: 37..716 e-value: 1.3E-199 score: 664.9
IPR036388	Winged helix-like DNA-binding domain superfamily	GENE3D	G3DSA:1.10.10.10		coord: 730..817 e-value: 1.9E-34 score: 119.4
IPR016157	Cullin, conserved site	PROSITE	PS01256	CULLIN_1	coord: 790..817
IPR036390	Winged helix DNA-binding domain superfamily	SUPERFAMILY	SSF46785	"Winged helix" DNA-binding domain	coord: 728..817
IPR036317	Cullin homology domain superfamily	SUPERFAMILY	SSF75632	Cullin homology domain	coord: 384..729
IPR016159	Cullin repeat-like-containing domain superfamily	SUPERFAMILY	SSF74788	Cullin repeat-like	coord: 30..382