Serine/threonine-protein kinase

Overview
NameSerine/threonine-protein kinase
Smed IDSMED30005365
Length (bp)1109
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine/threonine-protein kinase (SMED30005365) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine/threonine-protein kinase (SMED30005365) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine/threonine-protein kinase (SMED30005365) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine/threonine-protein kinase (SMED30005365) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30005365

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30005365h1SMcG0003622 SmedASXL_013335SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30005365h1SMcG0003622 dd_Smed_v4_15228_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30005365h1SMcG0003622 dd_Smed_v4_15228_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30005365h1SMcG0003622 dd_Smed_v4_15228_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynx musculatureSMED30005365h1SMcG0003622 dd_Smed_v4_15228_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30005365h1SMcG0003622 dd_Smed_v4_15228_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: PIM2 (Pim-2 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8987])

HSP 1 Score: 61.2326 bits (147), Expect = 6.549e-10
Identity = 61/255 (23.92%), Postives = 102/255 (40.00%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVN--KEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKL--FYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            +VF G+R+         ++ QV +K I R   +    L+  V    E   L  + A G  P V+  L  FE     M  L         +D++ +   + +         +     + H  G+ + DIK ENI+++      K+IDF         ++PY     GT  Y  PE  S  +Y+     ++S G LLY  +   +PF  +++ +   L     +      LI RC+    +     E+ILL  W  +
Sbjct:   45 TVFAGHRL--------TDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALL--HDEPY-TDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQT 288
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: RPS6KA5 (ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434])

HSP 1 Score: 62.003 bits (149), Expect = 7.486e-10
Identity = 51/196 (26.02%), Postives = 93/196 (47.45%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFE---YSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN 751
            KC+++K++      I   ++     KE   LKL +     P +V+  + F    +++++M+ L  N    ++ + K  H S+ +       L     + H  G+ + D+K EN++        +IKIIDF  +   P  N P       TL Y +PE+ +   Y+ + C ++S G +LYT L  Q+PF S  +++ 
Sbjct:  442 KCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGH---PNIVKLHEVFHDQLHTFLVMELL--NGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCF-TLHYAAPELLNQNGYD-ESCDLWSLGVILYTMLSGQVPFQSHDRSLT 630
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: RPS6KA5 (ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434])

HSP 1 Score: 62.003 bits (149), Expect = 8.824e-10
Identity = 51/196 (26.02%), Postives = 93/196 (47.45%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFE---YSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN 751
            KC+++K++      I   ++     KE   LKL +     P +V+  + F    +++++M+ L  N    ++ + K  H S+ +       L     + H  G+ + D+K EN++        +IKIIDF  +   P  N P       TL Y +PE+ +   Y+ + C ++S G +LYT L  Q+PF S  +++ 
Sbjct:  363 KCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGH---PNIVKLHEVFHDQLHTFLVMELL--NGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCF-TLHYAAPELLNQNGYD-ESCDLWSLGVILYTMLSGQVPFQSHDRSLT 551
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: PIM3 (Pim-3 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:19310])

HSP 1 Score: 60.077 bits (144), Expect = 1.579e-9
Identity = 51/251 (20.32%), Postives = 107/251 (42.63%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            +V+ G+R+ + + V  K+   V+ + +     +    + L    E   L+ + A G    V+  L  FE    ++++ +  +  +  +DF+ +   + +         +     + H  G+ + DIK EN++V+  + ++K+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   L     +  +  +LI  C+    ++    + I  H W 
Sbjct:   53 TVYAGSRIADGLPVAVKH---VVKERVTEWGSLGGATVPL----EVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: PIM1 (Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986])

HSP 1 Score: 56.9954 bits (136), Expect = 1.934e-8
Identity = 58/252 (23.02%), Postives = 109/252 (43.25%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            SV+ G RV + + V  K+  +      +R +D  +      V  E   LK + ++G+   V+  L  FE   S+V++ +  +  +  +DF+ +   + +         +     + H  G+ + DIK ENI+++    ++K+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   +     + S+   LI  C+    +    FE+I  H W  
Sbjct:   51 SVYSGIRVSDNLPVAIKHVEK------DRISDWGELPNGTRVPMEVVLLKKV-SSGFS-GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: prk-1 (Pim (Mammalian oncogene) Related Kinase [Source:UniProtKB/TrEMBL;Acc:K8ESD7])

HSP 1 Score: 67.0106 bits (162), Expect = 5.141e-12
Identity = 40/139 (28.78%), Postives = 66/139 (47.48%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTI---IDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            KHG+ + DIK EN++VN  T ++K++DF  + Y+  +         GT  YC PE F  + Y       +S G LL+  L  +LPF +E Q    CL  +     +  +  +L++ C+  + +       I  H W  +
Sbjct:  156 KHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKE---FQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQI---CLGNVKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMET 288
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: prk-1 (Pim (Mammalian oncogene) Related Kinase [Source:UniProtKB/TrEMBL;Acc:K8ESD7])

HSP 1 Score: 66.2402 bits (160), Expect = 1.340e-11
Identity = 40/139 (28.78%), Postives = 66/139 (47.48%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTI---IDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            KHG+ + DIK EN++VN  T ++K++DF  + Y+  +         GT  YC PE F  + Y       +S G LL+  L  +LPF +E Q    CL  +     +  +  +L++ C+  + +       I  H W  +
Sbjct:  179 KHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKE---FQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQI---CLGNVKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMET 311
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: prk-1 (Pim (Mammalian oncogene) Related Kinase [Source:UniProtKB/TrEMBL;Acc:K8ESD7])

HSP 1 Score: 65.855 bits (159), Expect = 1.649e-11
Identity = 40/139 (28.78%), Postives = 66/139 (47.48%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTI---IDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            KHG+ + DIK EN++VN  T ++K++DF  + Y+  +         GT  YC PE F  + Y       +S G LL+  L  +LPF +E Q    CL  +     +  +  +L++ C+  + +       I  H W  +
Sbjct:  156 KHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKE---FQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQI---CLGNVKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMET 288
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: prk-2 (Serine/threonine-protein kinase prk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q20443])

HSP 1 Score: 60.8474 bits (146), Expect = 5.070e-10
Identity = 41/134 (30.60%), Postives = 63/134 (47.01%), Query Frame = 2 
Query:  479 IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNR----CLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            + + D+K ENI+++ VT   K+IDF  +     S    +    GT  YC PE F    Y  +   ++S G LLY  L  +LPF +EK          LP    + ++  +LI +C+  +  +    E IL H W
Sbjct:  154 VLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQ---YSDFQGTRLYCPPEWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGPLPFFVPVSAEVKDLISKCLTFDPFQRCSLEAILNHPW 284
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: prk-2 (Serine/threonine-protein kinase prk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q20443])

HSP 1 Score: 60.8474 bits (146), Expect = 5.070e-10
Identity = 41/134 (30.60%), Postives = 63/134 (47.01%), Query Frame = 2 
Query:  479 IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNR----CLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            + + D+K ENI+++ VT   K+IDF  +     S    +    GT  YC PE F    Y  +   ++S G LLY  L  +LPF +EK          LP    + ++  +LI +C+  +  +    E IL H W
Sbjct:  154 VLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQ---YSDFQGTRLYCPPEWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGPLPFFVPVSAEVKDLISKCLTFDPFQRCSLEAILNHPW 284
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: Gprk2 (gene:FBgn0261988 transcript:FBtr0334555)

HSP 1 Score: 62.003 bits (149), Expect = 3.521e-10
Identity = 41/122 (33.61%), Postives = 60/122 (49.18%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKY 835
            K GI Y D K ENI+++     ++I D   ++  P        G +GT+GY +PEV   E+Y       FSFGCLLY  +E Q PF   K+ V R             E ++R ++++  KY
Sbjct:  428 KQGIVYRDCKPENILLDDHGH-VRISDLGLAVEIPEGE--MVRGRVGTVGYMAPEVIDNEKYAF-SPDWFSFGCLLYEMIEGQAPFRMRKEKVKR-------------EEVDRRVKEDPEKY 532
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: Gprk2 (gene:FBgn0261988 transcript:FBtr0085788)

HSP 1 Score: 62.003 bits (149), Expect = 3.521e-10
Identity = 41/122 (33.61%), Postives = 60/122 (49.18%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKY 835
            K GI Y D K ENI+++     ++I D   ++  P        G +GT+GY +PEV   E+Y       FSFGCLLY  +E Q PF   K+ V R             E ++R ++++  KY
Sbjct:  428 KQGIVYRDCKPENILLDDHGH-VRISDLGLAVEIPEGE--MVRGRVGTVGYMAPEVIDNEKYAF-SPDWFSFGCLLYEMIEGQAPFRMRKEKVKR-------------EEVDRRVKEDPEKY 532
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: SAK (gene:FBgn0026371 transcript:FBtr0078387)

HSP 1 Score: 55.8398 bits (133), Expect = 3.333e-8
Identity = 41/141 (29.08%), Postives = 71/141 (50.35%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDF--EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSE--KQTVNRCLPKMTIIDS----KAVELIERCIQKNVTKYFRFEDILLHSWF 871
            H I + DI L N+++ S    +KI DF     +  P   D  H+ + GT  Y SPEV S   + +    ++S GC+LYT L  + PF ++  + T+N+ +    I+ +    +A +LI + ++K   +    E +L H + 
Sbjct:  132 HNIMHRDISLSNLLL-SREMHVKIADFGLATQLKRP---DERHMTMCGTPNYISPEVVSRTSHGLPA-DVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFM 267
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0333673)

HSP 1 Score: 53.1434 bits (126), Expect = 2.404e-7
Identity = 40/145 (27.59%), Postives = 63/145 (43.45%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ----------TVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            ++G+ + D+K EN+++ S      +K+ DF  +I     +  +  G  GT GY SPEV   E Y  K   I++ G +LY  L    PF  E Q            +   P+   +  +A  LI + +  N  K     + L H W
Sbjct:  129 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAW-FGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW 271
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0300377)

HSP 1 Score: 53.1434 bits (126), Expect = 2.429e-7
Identity = 40/145 (27.59%), Postives = 63/145 (43.45%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ----------TVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            ++G+ + D+K EN+++ S      +K+ DF  +I     +  +  G  GT GY SPEV   E Y  K   I++ G +LY  L    PF  E Q            +   P+   +  +A  LI + +  N  K     + L H W
Sbjct:  129 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAW-FGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW 271
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr70 (Pim proto-oncogene, serine/threonine kinase, related 70 [Source:ZFIN;Acc:ZDB-GENE-120215-28])

HSP 1 Score: 83.5741 bits (205), Expect = 6.560e-18
Identity = 68/270 (25.19%), Postives = 129/270 (47.78%), Query Frame = 2 
Query:  107 YKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLK----LLQATGYCPVVVEYLQSFEY-----SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH-----GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            Y+++K++     G  V EA+RV+D    +V +K + + +D+  D L++  +     L+    +L   G  P V + +Q  E+     SY+++ +     +  +DF+++  H+  L + +    +  +    H     G+ + DIKLEN+++N  T ++K+IDF        S    +    GT  YC PE  S+ RY+ K   ++S G LLY  L  + P HS+    +  +     +  +  +L++ C+Q++  K      +  H WF 
Sbjct:    1 YRIVKKLGQGGYGT-VFEAVRVRDG--LEVAMKVVMKSSDM--DYLSIPGHPTPLPLEVALTILANNG--PTVPQIIQMLEWQERPDSYIMILERPSPCEDLFDFLER--HLGTLSENMTRHIMWQVVQAAHMCCQRGVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSA---YTTFCGTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDLTDERIWIKPGLSKECCQLVQSCLQRSPRKRIALGKLSSHRWFK 258
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr74 (Pim proto-oncogene, serine/threonine kinase, related 74 [Source:ZFIN;Acc:ZDB-GENE-120215-19])

HSP 1 Score: 81.2629 bits (199), Expect = 4.159e-17
Identity = 68/271 (25.09%), Postives = 128/271 (47.23%), Query Frame = 2 
Query:  104 NYKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLK----LLQATGYCPVVVEYLQSFEY-----SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH-----GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
             Y+++K++     G  VLEA+R+ D    +V +K + + +D+  D L++  +     L+    +L   G  P V + +Q  E+     SY+++ +     +  +DF+++  H   L + +    +  +    H     G+ + DIKLEN+++N  T ++K+IDF        S    +    GT  YC PE  S+ RY+ K   ++S G LLY  L  + P HS+    +      + +  +  +L++ C+Q++  K      +  H WF 
Sbjct:    5 RYRIVKKLGQGGYGT-VLEAVRLTDG--LEVAMKVVVKSSDM--DYLSIPGHPTPLPLEVALTILANNG--PTVPQIIQMLEWQERSDSYIMILERPSPCEDLFDFLER--HRGTLSEDVARHIMRQVVQAAHMCCQRGVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSA---YTTFCGTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDMTDERTWIKSGLSKECCQLVQSCLQRSPRKRIALGKLSSHRWFK 263
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr72 (Pim proto-oncogene, serine/threonine kinase, related 72 [Source:ZFIN;Acc:ZDB-GENE-091118-122])

HSP 1 Score: 79.7221 bits (195), Expect = 1.234e-16
Identity = 67/270 (24.81%), Postives = 129/270 (47.78%), Query Frame = 2 
Query:  104 NYKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLK----LLQATGYCPVVVEYLQSFEY-----SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH-----GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
             Y+++K++     G  VLEA+R+ D    +V +K + + +D+  D L++  +     L+    +L   G  P V + ++  E+     SY+++ +     +  +DF+++  H   L + +    +  +    H     G+ + DIKLEN+++N  T ++K+IDF        S    +    GT  YC PE  S+ RY+ K   ++S G LLY  L  + P HS+    +      + + ++  +L++ C+Q++  K      +  H WF
Sbjct:    6 RYRIVKKLGQGGYGT-VLEAVRLTDG--LEVAMKVVVKSSDM--DYLSIPGHPTPLPLEVALTILANNG--PTVPQIIRMLEWQERSDSYIMILERPSPCEDLFDFLER--HRGTLSENMTRHIMWQVVQAAHMCCQRGVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSA---YTTFCGTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDLTDERTWIKSGLSTECCQLVQSCLQRSPRKRIALGKLSSHRWF 263
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: si:dkey-58i8.5 (si:dkey-58i8.5 [Source:ZFIN;Acc:ZDB-GENE-160728-66])

HSP 1 Score: 80.1073 bits (196), Expect = 4.265e-16
Identity = 42/136 (30.88%), Postives = 72/136 (52.94%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFE-DSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            + G+ + DIKLEN+++N+ T D+ +IDF   +++       YH    GT  YC PE F   +Y  +   ++S G LLYT +   +P H++++ +   L  +  +  +   LI  C+  + ++    E ILLH WF 
Sbjct:  252 RRGVLHRDIKLENLIINTETMDVTLIDFGCGNLFHETE---YHT-FSGTEMYCPPEFFETGKYFARPATVYSLGVLLYTMVCGYMPDHTDREKMQHWLWYLPSLSCECSHLINACLHPDPSERITLEQILLHDWFT 383
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr185 (Pim proto-oncogene, serine/threonine kinase, related 185 [Source:ZFIN;Acc:ZDB-GENE-081104-450])

HSP 1 Score: 77.411 bits (189), Expect = 1.085e-15
Identity = 67/254 (26.38%), Postives = 114/254 (44.88%), Query Frame = 2 
Query:  146 NRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKL---NLYVNKEFFFLKLLQATGYCPVVVEYL---QSFEYSYVIMKKLSD--NWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXX--KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
              V   IRV D  K  V +K + +  ++   K+   +  V +E   + L+      P +++ L   +S EY  +++++     + + F  + D  N IS+    +    +        + G+++ DIKLEN+++N  T  IK+IDF       N     +    GT  Y  PE F   R + K   ++S G LL+  L  +LP    ++ V R   K   +  + ++LI  C+Q    K    E IL H+WF S
Sbjct:   19 GEVFSGIRVSDFRK--VAIKYVKKTKEMKTIKIAPSDKSVPQEVGLMYLMSRGPNVPQIIQLLDWYESPEYYVLVLERPRACVDMRQFISWYD--NKISEENARVVTHQVVTAANACCERGVYHSDIKLENLLINPHTLQIKLIDFGAGRLISNLG---YTTFCGTRVYAPPEFFKRGRLHAKPATVYSIGVLLFILLYGRLPLKELQKIVKRTW-KPEDLSKECIDLICSCLQSKPDKRIPLEKILQHNWFQS 264
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: ncbp1 (nuclear cap binding protein subunit 1 [Source:Xenbase;Acc:XB-GENE-5841194])

HSP 1 Score: 62.003 bits (149), Expect = 3.850e-10
Identity = 55/252 (21.83%), Postives = 106/252 (42.06%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHG--IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            +V+ G R+ + + V  K+ S+  +  +   N          V  E + LK  + +  C  V+  L  +E    ++I+ +  +  +  +DF+ +   + +         +     + H   + + DIK ENI+V+  T ++K+IDF          D  +    GT  Y  PE     +Y+ +   ++S G LLY  +   +PF  + + +   +     +  +   LIE C+ K  +     E IL H W +
Sbjct:   50 TVYSGVRISDKLPVAIKHVSRDRIGEMKHMNGTL-------VPLEIYLLK--KVSNGCRGVIRLLDWYERPDGFIIIMERPEPVQDLFDFITERGALGEELATNFFRQVVEAVRHCHSCDVVHRDIKDENILVDLRTAELKLIDFGSGALL---RDAVYTDFDGTRVYSPPEWIRFHKYHGRSATVWSLGILLYDMVCGDIPFEHDDEILKGKIQYRCRVSRECQHLIEWCLSKRPSDRPSLEQILAHPWMS 289
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: ncbp1 (nuclear cap binding protein subunit 1 [Source:Xenbase;Acc:XB-GENE-5841194])

HSP 1 Score: 61.2326 bits (147), Expect = 6.433e-10
Identity = 55/252 (21.83%), Postives = 106/252 (42.06%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHG--IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            +V+ G R+ + + V  K+ S+  +  +   N          V  E + LK  + +  C  V+  L  +E    ++I+ +  +  +  +DF+ +   + +         +     + H   + + DIK ENI+V+  T ++K+IDF          D  +    GT  Y  PE     +Y+ +   ++S G LLY  +   +PF  + + +   +     +  +   LIE C+ K  +     E IL H W +
Sbjct:   69 TVYSGVRISDKLPVAIKHVSRDRIGEMKHMNGTL-------VPLEIYLLK--KVSNGCRGVIRLLDWYERPDGFIIIMERPEPVQDLFDFITERGALGEELATNFFRQVVEAVRHCHSCDVVHRDIKDENILVDLRTAELKLIDFGSGALL---RDAVYTDFDGTRVYSPPEWIRFHKYHGRSATVWSLGILLYDMVCGDIPFEHDDEILKGKIQYRCRVSRECQHLIEWCLSKRPSDRPSLEQILAHPWMS 308
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: pus7l (pseudouridine synthase 7 like [Source:Xenbase;Acc:XB-GENE-999746])

HSP 1 Score: 62.003 bits (149), Expect = 7.214e-10
Identity = 51/186 (27.42%), Postives = 91/186 (48.92%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFD--IKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFH 730
            KC +R+        I   ++     +E   L+L Q       + E L    +SY++M+ L D  +L  D + K    S+++      +L     + H  G+ + D+K EN++++S   +  +K+IDF  +   P  + P H     TL Y +PE+FS + Y+ + C +++ G +LYT L  Q+PF 
Sbjct:  396 KCQHRQTQKEYAVKIISRRMEANTQREVAALRLCQGHPNIVTLHEVLHDQYHSYLVMELL-DGGELL-DRIKKQACFSEVEASSLMRSLVSAVSHMHSVGVVHRDLKPENLLLSSPGENAVLKVIDFGFARLRPPGSRPLHTPCF-TLHYAAPELFSNQGYD-ELCDLWTLGVILYTMLSGQVPFQ 577
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: pus7l (pseudouridine synthase 7 like [Source:Xenbase;Acc:XB-GENE-999746])

HSP 1 Score: 62.003 bits (149), Expect = 8.407e-10
Identity = 51/186 (27.42%), Postives = 91/186 (48.92%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFD--IKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFH 730
            KC +R+        I   ++     +E   L+L Q       + E L    +SY++M+ L D  +L  D + K    S+++      +L     + H  G+ + D+K EN++++S   +  +K+IDF  +   P  + P H     TL Y +PE+FS + Y+ + C +++ G +LYT L  Q+PF 
Sbjct:  436 KCQHRQTQKEYAVKIISRRMEANTQREVAALRLCQGHPNIVTLHEVLHDQYHSYLVMELL-DGGELL-DRIKKQACFSEVEASSLMRSLVSAVSHMHSVGVVHRDLKPENLLLSSPGENAVLKVIDFGFARLRPPGSRPLHTPCF-TLHYAAPELFSNQGYD-ELCDLWTLGVILYTMLSGQVPFQ 617
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: pus7l (pseudouridine synthase 7 like [Source:Xenbase;Acc:XB-GENE-999746])

HSP 1 Score: 62.003 bits (149), Expect = 8.629e-10
Identity = 51/189 (26.98%), Postives = 93/189 (49.21%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFD--IKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEK 739
            KC +R+        I   ++     +E   L+L Q       + E L    +SY++M+ L D  +L  D + K    S+++      +L     + H  G+ + D+K EN++++S   +  +K+IDF  +   P  + P H     TL Y +PE+FS + Y+ + C +++ G +LYT L  Q+PF  ++
Sbjct:  390 KCQHRQTQKEYAVKIISRRMEANTQREVAALRLCQGHPNIVTLHEVLHDQYHSYLVMELL-DGGELL-DRIKKQACFSEVEASSLMRSLVSAVSHMHSVGVVHRDLKPENLLLSSPGENAVLKVIDFGFARLRPPGSRPLHTPCF-TLHYAAPELFSNQGYD-ELCDLWTLGVILYTMLSGQVPFQVKR 574
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Pim3 (proviral integration site 3 [Source:MGI Symbol;Acc:MGI:1355297])

HSP 1 Score: 62.3882 bits (150), Expect = 1.970e-10
Identity = 51/251 (20.32%), Postives = 106/251 (42.23%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            +V+ G+R+ + + V  K+        +  +   +     + V  E   L+ + A G    V+  L  FE    ++++ +  +  +  +DF+ +   + +         +     + H  G+ + DIK EN++V+  + ++K+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   L     +  +  +LIE C+    ++    + I  H W 
Sbjct:   53 TVYAGSRIADGLPVAVKH-------VVKERVTEWGSLGGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWM 293
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Pim2 (proviral integration site 2 [Source:MGI Symbol;Acc:MGI:97587])

HSP 1 Score: 62.3882 bits (150), Expect = 2.792e-10
Identity = 61/257 (23.74%), Postives = 103/257 (40.08%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKN----DIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKL--FYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            +VF G+RV         ++ QV +K I+R          D +   +     + K+ +  G+ P V+  L  FE     M  L         +D++ +   + +         +     + H  G+ + DIK ENI+++     IK+IDF         ++PY     GT  Y  PE  S  +Y+     ++S G LLY  +   +PF  +++ +   L     +      LI RC+          E+ILL  W  S
Sbjct:  104 TVFAGHRV--------TDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLW-KVGEGNGH-PGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALL--HDEPY-TDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQS 347
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Pim2 (proviral integration site 2 [Source:MGI Symbol;Acc:MGI:97587])

HSP 1 Score: 62.003 bits (149), Expect = 3.210e-10
Identity = 61/257 (23.74%), Postives = 103/257 (40.08%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKN----DIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKL--FYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            +VF G+RV         ++ QV +K I+R          D +   +     + K+ +  G+ P V+  L  FE     M  L         +D++ +   + +         +     + H  G+ + DIK ENI+++     IK+IDF         ++PY     GT  Y  PE  S  +Y+     ++S G LLY  +   +PF  +++ +   L     +      LI RC+          E+ILL  W  S
Sbjct:  110 TVFAGHRV--------TDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLW-KVGEGNGH-PGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALL--HDEPY-TDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQS 353
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1920336])

HSP 1 Score: 60.8474 bits (146), Expect = 1.398e-9
Identity = 49/196 (25.00%), Postives = 92/196 (46.94%), Query Frame = 2 
Query:  203 KCINRKND------IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFE---YSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN 751
            KC+++K +      I   ++     KE   LKL +     P +V+  + F    +++++M+ L  N    ++ + +  H S+ +       L     + H  G+ + D+K EN++        +IK+IDF  +   P  N P       TL Y +PE+ +   Y+ + C ++S G +LYT L  Q+PF S  +++ 
Sbjct:  441 KCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGH---PNIVKLHEVFHDQLHTFLVMELL--NGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCF-TLHYAAPELLTHNGYD-ESCDLWSLGVILYTMLSGQVPFQSHDRSLT 629
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Pim1 (proviral integration site 1 [Source:MGI Symbol;Acc:MGI:97584])

HSP 1 Score: 59.6918 bits (143), Expect = 1.621e-9
Identity = 36/134 (26.87%), Postives = 61/134 (45.52%), Query Frame = 2 
Query:  476 GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            G+ + DIK ENI+++    +IK+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   +     + S+   LI+ C+    +    FE+I  H W   
Sbjct:  162 GVLHRDIKDENILIDLSRGEIKLIDFGSGALL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQG 292
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|Q93VK0|PPCK2_ARATH (Phosphoenolpyruvate carboxylase kinase 2 OS=Arabidopsis thaliana OX=3702 GN=PPCK2 PE=1 SV=2)

HSP 1 Score: 67.0106 bits (162), Expect = 2.861e-11
Identity = 41/141 (29.08%), Postives = 73/141 (51.77%), Query Frame = 2 
Query:  479 IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ--------TVNRCLP--KMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            + + D+K +N++V+ V+  +K+ DF  +++          G++GT  Y +PEV    +Y+ K   I+S G ++YT L  + PF+ E            N   P  K   + S+A +L+ + I ++V++ F  ED L HSW 
Sbjct:  133 VVHRDVKPDNVLVDLVSGGVKLCDFGSAVWLGGETAE---GVVGTPYYVAPEVVMGRKYDEK-VDIWSAGVVIYTMLAGEPPFNGETAEDIFESILRGNLRFPPKKFGSVSSEAKDLLRKMICRDVSRRFSAEDALRHSWM 269
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|Q9UTH3|PPK6_SCHPO (Serine/threonine-protein kinase ppk6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ppk6 PE=1 SV=2)

HSP 1 Score: 64.6994 bits (156), Expect = 5.634e-10
Identity = 65/252 (25.79%), Postives = 121/252 (48.02%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVV--VEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHG--IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            + ++ N+V E I +K  +KS++++    R  D+        V  E   L  L+A  +  +V  + + +  E  Y++ +       LF D+++    IS+ +       +AL   + H   I + DIK EN+++       ++IDF  S  S   N P+     GT+G+ +PE+   E+Y  K   I++ G LLYT +  + P+++ ++ ++  L     +    V+LI R + +NV      E+ L H WF+
Sbjct:  520 ATYKSNKVHEVI-LKSISKSRILLDSWMRDKDLGT------VPMEISILHFLKAHSHPNIVKMITFFEDNENYYLLTEPQKPGIDLF-DYIELKPSISEKESKAIFFQIALAVAHLHSFDIIHRDIKDENVILEGNGC-ARLIDFGSS--SLTKNGPFDT-FRGTVGFAAPELLRGEKYLGKEQDIWALGILLYTIVYRENPYYNIEEILDAKLRIPFELSKDNVDLICRMLDRNVHDRITIEETLQHHWFD 759
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|O70444|PIM3_RAT (Serine/threonine-protein kinase pim-3 OS=Rattus norvegicus OX=10116 GN=Pim3 PE=1 SV=3)

HSP 1 Score: 63.1586 bits (152), Expect = 9.048e-10
Identity = 51/251 (20.32%), Postives = 106/251 (42.23%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            +V+ G+R+ + + V  K+        +  +   +     + V  E   L+ + A G    V+  L  FE    ++++ +  +  +  +DF+ +   + +         +     + H  G+ + DIK EN++V+  + ++K+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   L     +  +  +LIE C+    ++    + I  H W 
Sbjct:   53 TVYAGSRIADGLPVAVKH-------VVKERVTEWGSLGGMAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWM 293
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|P58750|PIM3_MOUSE (Serine/threonine-protein kinase pim-3 OS=Mus musculus OX=10090 GN=Pim3 PE=1 SV=1)

HSP 1 Score: 62.3882 bits (150), Expect = 1.378e-9
Identity = 51/251 (20.32%), Postives = 106/251 (42.23%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            +V+ G+R+ + + V  K+        +  +   +     + V  E   L+ + A G    V+  L  FE    ++++ +  +  +  +DF+ +   + +         +     + H  G+ + DIK EN++V+  + ++K+IDF          D  +    GT  Y  PE     RY+ +   ++S G LLY  +   +PF  +++ +   L     +  +  +LIE C+    ++    + I  H W 
Sbjct:   53 TVYAGSRIADGLPVAVKH-------VVKERVTEWGSLGGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVL---KDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWM 293
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|Q08217|PSK2_YEAST (Serine/threonine-protein kinase PSK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PSK2 PE=1 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 1.501e-9
Identity = 40/135 (29.63%), Postives = 70/135 (51.85%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCL--PKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
             GI + DIK EN++V+S  F +K+IDF  + Y  +   P+ +  +GT+ Y +PEV     Y  K   I++ G LLYT +  + P+++  + +   L   K   +  + + LI+R + + V K    ++I    W 
Sbjct:  969 QGIVHRDIKDENVIVDSHGF-VKLIDFGSAAYIKSG--PFDV-FVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWL 1099
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A2P1ERR9 (PIM-1-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 4.323e-28
Identity = 71/211 (33.65%), Postives = 114/211 (54.03%), Query Frame = 2 
Query:  245 NLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            N Y+ KE FFL+ L    Y P ++EY+    +S V M+ +  +W     ++ +      +K I++N+   +  ++  G ++ DIK ENIMVN  T +IK+ID ED +Y  N   P  I  +GTLG+ SPE +    YN+K   +F+ GCL Y C+E +  F ++ +T    LP+M +    A   I  CI+ +  +   F+D+L H W  +
Sbjct:    7 NFYIPKELFFLEELSQYEYVPKLIEYIDENNWSTVAMEYIGGDWMDLSYYLVEFEGEKLVKTIMRNLISIVYKMSDIGYYHRDIKPENIMVNQRTLEIKLIDLEDMLYDENE-IPKCISELGTLGFQSPETYGKVPYNLKQSLVFNIGCLAYFCIEYEYAFDTKIETQKCLLPEMKVSSKLARSFITECIKLDPNERIEFDDLLFHDWLEN 216
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: F1QR20 (Pim proto-oncogene, serine/threonine kinase,-related 70 (Fragment) OS=Danio rerio OX=7955 GN=pimr70 PE=3 SV=2)

HSP 1 Score: 83.5741 bits (205), Expect = 1.468e-14
Identity = 68/270 (25.19%), Postives = 129/270 (47.78%), Query Frame = 2 
Query:  107 YKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLK----LLQATGYCPVVVEYLQSFEY-----SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH-----GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            Y+++K++     G  V EA+RV+D    +V +K + + +D+  D L++  +     L+    +L   G  P V + +Q  E+     SY+++ +     +  +DF+++  H+  L + +    +  +    H     G+ + DIKLEN+++N  T ++K+IDF        S    +    GT  YC PE  S+ RY+ K   ++S G LLY  L  + P HS+    +  +     +  +  +L++ C+Q++  K      +  H WF 
Sbjct:    1 YRIVKKLGQGGYGT-VFEAVRVRDG--LEVAMKVVMKSSDM--DYLSIPGHPTPLPLEVALTILANNG--PTVPQIIQMLEWQERPDSYIMILERPSPCEDLFDFLER--HLGTLSENMTRHIMWQVVQAAHMCCQRGVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSA---YTTFCGTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDLTDERIWIKPGLSKECCQLVQSCLQRSPRKRIALGKLSSHRWFK 258
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A146IAN3 (Protein kinase domain-containing protein OS=Mycena chlorophos OX=658473 GN=MCHLO_13042 PE=4 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 2.492e-14
Identity = 46/141 (32.62%), Postives = 71/141 (50.35%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYS-PNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN-----RCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            +HG  + DIK ENI+++   F +K++DF  S+   P++  PYH    GT  Y SPE+   + Y     ++FS G LL   L    PF + +  +        LPK  + DS A++LI  C++ +V K    E +  H W  
Sbjct:  163 RHGATHRDIKDENIVIDDAMF-VKLVDFGASVVEDPSAPRPYHTTFFGTSAYASPEILKKQPYQAPPAEVFSIGVLLVFMLTGYSPFLTPRDAMEGNIVLTELPK-ELHDSPALDLIRVCLEVDVKKRATIEQVRAHPWLR 301
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A1C7NG27 (Serine/threonine-protein kinase ppk6 OS=Choanephora cucurbitarum OX=101091 GN=ppk6_2 PE=4 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 9.275e-14
Identity = 67/246 (27.24%), Postives = 127/246 (51.63%), Query Frame = 2 
Query:  161 AIRVKDKNKSQVIVKCINRKNDIFD----DKLNLYVNKEFFFLKLLQATGY--CPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXX--XXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            A R  D +K +V++K I +   + D    D+    V  E   L+ LQ   +  C  +V +++  +Y +++M  L ++  LF D++++  ++++ +       +A A   +++HGI + DIK ENI+++     + +IDF  + Y     D       GTL YC+PE+   + Y      I+S G LLYT +  + PFH+  + + + L    ++  ++ +LI   +Q++V   F  +D+L H WF+
Sbjct:  451 AYRKDDPSKKKVVIKYIFKSRILIDSWIRDRQLGSVPMEIHILRKLQRHPHVNCCQLVTFMEDEDYYFLVMDLLDNSMDLF-DYIERNKNMTENETKRIFYQVACATKHLHQHGIVHRDIKDENIILDDQGRAL-LIDFGCATYY--KRDKRFDTFTGTLEYCAPEMLRGQPYAGPPQDIWSCGVLLYTLIYQENPFHNIDEIMEKELRVPFVLSEESFDLITHMLQRDVESRFDIDDVLNHPWFH 692
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: F1QRN5 (Pim proto-oncogene, serine/threonine kinase,-related 74 (Fragment) OS=Danio rerio OX=7955 GN=pimr74 PE=3 SV=2)

HSP 1 Score: 81.2629 bits (199), Expect = 9.307e-14
Identity = 68/271 (25.09%), Postives = 128/271 (47.23%), Query Frame = 2 
Query:  104 NYKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLK----LLQATGYCPVVVEYLQSFEY-----SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH-----GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
             Y+++K++     G  VLEA+R+ D    +V +K + + +D+  D L++  +     L+    +L   G  P V + +Q  E+     SY+++ +     +  +DF+++  H   L + +    +  +    H     G+ + DIKLEN+++N  T ++K+IDF        S    +    GT  YC PE  S+ RY+ K   ++S G LLY  L  + P HS+    +      + +  +  +L++ C+Q++  K      +  H WF 
Sbjct:    5 RYRIVKKLGQGGYGT-VLEAVRLTDG--LEVAMKVVVKSSDM--DYLSIPGHPTPLPLEVALTILANNG--PTVPQIIQMLEWQERSDSYIMILERPSPCEDLFDFLER--HRGTLSEDVARHIMRQVVQAAHMCCQRGVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSA---YTTFCGTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDMTDERTWIKSGLSKECCQLVQSCLQRSPRKRIALGKLSSHRWFK 263
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000012249.2 (pep primary_assembly:Astyanax_mexicanus-2.0:10:9011990:9016852:-1 gene:ENSAMXG00000035243.1 transcript:ENSAMXT00000012249.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.0998 bits (183), Expect = 1.290e-14
Identity = 48/139 (34.53%), Postives = 71/139 (51.08%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDF--EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN--RCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            + G+F+ DIKLEN ++N  T ++K+IDF   D + S   N        GT  YC PE     RY+ K   ++S G LLY  +    PF ++ +     RC+ K   +  +  +LI RC+Q        FE IL H+WF+
Sbjct:  230 ERGVFHRDIKLENFLINPRTLELKLIDFGCGDWVKSTGYNS-----FAGTRIYCPPEHLIEGRYHAKPATVWSLGVLLYRMVCGFFPFRNDWEICGGLRCIRKG--LSHECCDLIMRCLQPRPNWRPCFEQILHHNWFH 361
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000005084.2 (pep primary_assembly:Astyanax_mexicanus-2.0:10:9011990:9016852:-1 gene:ENSAMXG00000035243.1 transcript:ENSAMXT00000005084.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 74.7146 bits (182), Expect = 1.972e-14
Identity = 48/139 (34.53%), Postives = 71/139 (51.08%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDF--EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN--RCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            + G+F+ DIKLEN ++N  T ++K+IDF   D + S   N        GT  YC PE     RY+ K   ++S G LLY  +    PF ++ +     RC+ K   +  +  +LI RC+Q        FE IL H+WF+
Sbjct:  268 ERGVFHRDIKLENFLINPRTLELKLIDFGCGDWVKSTGYNS-----FAGTRIYCPPEHLIEGRYHAKPATVWSLGVLLYRMVCGFFPFRNDWEICGGLRCIRKG--LSHECCDLIMRCLQPRPNWRPCFEQILHHNWFH 399
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000042000.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001279.1:211907:217070:-1 gene:ENSAMXG00000033183.1 transcript:ENSAMXT00000042000.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.1738 bits (178), Expect = 4.302e-14
Identity = 44/134 (32.84%), Postives = 63/134 (47.01%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            K G+ + DIKLENI++N  T +IK+IDF        S   Y     GT  YC PE F   RY      ++S G LLY  +   +PF  E + +   L     +  +  +L+  C+Q+        + IL H WF
Sbjct:  195 KRGVIHRDIKLENILINMETTEIKLIDFGCGDLIKRSGYNY---FEGTFQYCPPEFFITGRYCATPATVWSLGVLLYEMVCGSVPFKDESEIIGGPLRFKDDLSDEFCDLVRWCLQRKPISRPSLQQILKHKWF 325
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000030133.1 (serine/threonine-protein kinase pim-3-like [Source:NCBI gene;Acc:103028120])

HSP 1 Score: 72.4034 bits (176), Expect = 6.292e-14
Identity = 40/135 (29.63%), Postives = 68/135 (50.37%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFE-DSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            K G+ + DIKLEN ++N+ TF++K++DF     ++    + Y    IGT  +C PE F +  Y+     ++S G  LYT +    PF +  + +   L     + ++  +LI  C+Q + T     + I  H WF
Sbjct:  187 KRGVLHRDIKLENFLINTNTFEVKLVDFGCGDFFTERELNHY----IGTEEFCPPEFFLSRSYHAAPSTVWSLGVFLYTMVHGYHPFTTRHEIIAGDLRFGDHLSNEVCDLIRWCLQDDPTWRPSLQQIFGHPWF 317
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000032916.1 (serine/threonine-protein kinase pim-2-like [Source:NCBI gene;Acc:111189176])

HSP 1 Score: 72.0182 bits (175), Expect = 1.352e-13
Identity = 43/145 (29.66%), Postives = 66/145 (45.52%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS*YV*NSVLC 904
            K G+F+ DIK++NI++N+ T  +K+IDF            Y     GTL YC PE F   RY      ++S G +L+  +    PF  E + +   L     +  +  EL+  C+Q   +     + IL H WF S +      C
Sbjct:  203 KRGVFHRDIKVDNILINTDTLKLKLIDFGCGDLIRRYGYSY---FEGTLEYCPPEFFLKGRYCAIPATVWSLGVMLFQVVSASFPFKDEDEILGGQLNFKDGLSDEFHELVRLCLQAQPSSRPNLQQILDHKWFKSSFPAQERFC 344
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:ZFIN;Acc:ZDB-GENE-130530-693])

HSP 1 Score: 58.5362 bits (140), Expect = 9.513e-10
Identity = 47/179 (26.26%), Postives = 79/179 (44.13%), Query Frame = 2 
Query:  227 IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVN 751
            I   ++     +E   LKL  A      +++      ++Y++M+ L     L  + + K +H S+ +       L       H  G+ + D+K EN++    T    IK+IDF  +   P  N P       TL Y +PE+     Y+ + C ++S G +LYT L  Q+PF S  Q + 
Sbjct:  141 IVSKRMEANTQREIAALKLCHAHPNIVNIIDVYHDTLHTYLVMELLKGGELL--ERIKKRSHFSETEASRIMRKLVSATSFMHDTGVVHRDLKPENLLFADDTEGAAIKVIDFGFARLKPQDNAPLKTPCF-TLQYAAPELLQHAGYD-ESCDVWSLGVILYTMLSGQVPFQSHGQPMT 315
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: GRK5 (G protein-coupled receptor kinase 5 [Source:HGNC Symbol;Acc:HGNC:4544])

HSP 1 Score: 57.7658 bits (138), Expect = 1.763e-9
Identity = 34/94 (36.17%), Postives = 48/94 (51.06%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNR 754
             GI Y D+K ENI+++     I+I D   ++  P        G +GT+GY +PEV + ERY       +  GCL+Y  LE   PF   K+ V R
Sbjct:  239 EGIVYRDLKPENILLDDYGH-IRISDLGLAVKIPEGES--IRGRVGTVGYMAPEVINNERYTF-WPDWWGLGCLVYEMLEGHSPFRGRKEKVKR 328
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003384.1 (pep scaffold:Pmarinus_7.0:GL476716:1230:12573:1 gene:ENSPMAG00000003093.1 transcript:ENSPMAT00000003384.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 2.840e-9
Identity = 46/178 (25.84%), Postives = 77/178 (43.26%), Query Frame = 2 
Query:  377 KLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLEN-IMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAE----RYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTV--------NRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            +LF+  V  V+H                  ++HGI   D+KL   +  +     +++   ED +   +S+D      +G   Y SPE+ +A     RY+ +   ++S G +LYT L  Q PFH  + T            LP+   +  KA  LI   ++++ ++     DIL H WF
Sbjct:  154 RLFHQAVSAVDHC-----------------HQHGIVLRDLKLRKFVFRDEDRMRLRLEGLED-VCVLHSDDDSLAEKVGCPAYVSPEILTAGGSSGRYSGRAADVWSLGVMLYTMLVGQYPFHESEPTALFARIRRGQYALPEA--LSPKARCLIRDLLRRDPSERLSARDILHHPWF 311
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008748.1 (pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 gene:ENSPMAG00000007907.1 transcript:ENSPMAT00000008748.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.7582 bits (125), Expect = 5.906e-8
Identity = 40/145 (27.59%), Postives = 63/145 (43.45%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSV--TFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ----------TVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            +HGI + D+K EN+++ S      +K+ DF  +I        +  G  GT GY SPEV   + Y  K   +++ G +LY  L    PF  E Q            +   P+   + ++A  LI + +  N  K     + L H W
Sbjct:  129 QHGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAW-FGFAGTPGYLSPEVLRKDPYG-KPVDMWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTAEAKNLINQMLTINPAKRITAAEALKHPW 271
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: camk2a (calcium/calmodulin-dependent protein kinase II alpha [Source:ZFIN;Acc:ZDB-GENE-051113-72])

HSP 1 Score: 52.373 bits (124), Expect = 6.058e-8
Identity = 40/143 (27.97%), Postives = 61/143 (42.66%), Query Frame = 2 
Query:  476 GIFYMDIKLENIMVNSVT--FDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ----------TVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSW 868
            GI + D+K EN+++ S T    +K+ DF  +I        +  G  GT GY SPEV   + Y  K   +++ G +LY  L    PF  E Q            +   P+   +  +A  LI + +  N  K     + L H W
Sbjct:   39 GIVHRDLKPENLLLASKTKGAAVKLADFGLAIEVQGEQQAW-FGFAGTPGYLSPEVLRKDPYG-KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKSLINQMLTINPAKRITASEALTHPW 179
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: PSK2 (PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005405])

HSP 1 Score: 63.5438 bits (153), Expect = 2.161e-11
Identity = 40/135 (29.63%), Postives = 70/135 (51.85%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCL--PKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
             GI + DIK EN++V+S  F +K+IDF  + Y  +   P+ +  +GT+ Y +PEV     Y  K   I++ G LLYT +  + P+++  + +   L   K   +  + + LI+R + + V K    ++I    W 
Sbjct:  969 QGIVHRDIKDENVIVDSHGF-VKLIDFGSAAYIKSG--PFDV-FVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWL 1099
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: PSK1 (PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000015])

HSP 1 Score: 61.6178 bits (148), Expect = 9.569e-11
Identity = 42/127 (33.07%), Postives = 62/127 (48.82%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFH------------------SE------KQTVNRCLPKMTIID 781
             GI + DIK EN++V+S  F +KIIDF  + Y    + P+ +  +GT+ Y +PEV     Y  +   I++ G LLYT +  + PF+                  SE      K  +NRC+PK   ID
Sbjct: 1224 QGIVHRDIKDENVIVDSKGF-VKIIDFGSAAYV--KSGPFDV-FVGTIDYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEILEGDLKFNNAEEVSEDCIELIKSILNRCVPKRPTID 1346
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130])

HSP 1 Score: 53.1434 bits (126), Expect = 2.221e-8
Identity = 42/142 (29.58%), Postives = 66/142 (46.48%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMV--NSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSE-KQTVNRCLPKMTI-----IDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            K  I + DIK ENI++  N+V   IK+ DF  SI +P  N      + GT+ Y SPE+  +  Y+      ++ G L +  L    PF  E K T  + +  + I     I   A +LI + ++ +     R  D+ +H W 
Sbjct:  220 KKNIIHRDIKPENILIGFNNV---IKLTDFGWSIINPPEN--RRKTVCGTIDYLSPEMVESREYD-HTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWI 355
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 53.5286 bits (127), Expect = 3.037e-8
Identity = 40/144 (27.78%), Postives = 73/144 (50.69%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDFE-DSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDS------KAVELIERCIQKNVTKYFRFEDILLHSWFNS*Y 883
            + I + D+K+ENIM++S + +IKIIDF   +I+  +     H    G+L + +PE+  A+ Y      I+SFG +LY  +  ++PF  E  ++     K   +D       + + L+ R I  +  +    ++++ H W N  Y
Sbjct:  242 NNIVHRDLKIENIMISS-SGEIKIIDFGLSNIF--DYRKQLHT-FCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGY 381
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: PKH1 (Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh2p; PKH1 has a paralog, PKH2, that arose from the whole genome duplication [Source:SGD;Acc:S000002898])

HSP 1 Score: 51.2174 bits (121), Expect = 1.470e-7
Identity = 33/101 (32.67%), Postives = 51/101 (50.50%), Query Frame = 2 
Query:  476 GIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSP----NSND--PY------HIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQ 742
            GI + DIK ENI+++     +K+ DF  +   P    N+ D  PY          +GT  Y SPE+ + + Y    C I++FGC+LY  L  + PF +  +
Sbjct:  244 GIIHRDIKPENILLDK-NMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLN-DNYTDSRCDIWAFGCILYQMLAGKPPFKAANE 342
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO46861 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNH5])

HSP 1 Score: 79.7221 bits (195), Expect = 5.744e-17
Identity = 62/247 (25.10%), Postives = 113/247 (45.75%), Query Frame = 2 
Query:  152 VLEAIRVKDKNKSQVIVKCINRKND-IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXX--XKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            V    RV+D     V +K I + N   F++   + V  E +  ++L      P VV     FEY  +YV++ +   +++  +D++ +   +S+ +       +          G+F+ DIK EN+++++ T  +K+ DF       N+    +    GT  YC PE F   RY+ + C ++S G LL+  L   +PF ++ + V   L     +  +A  L+   + K+ +     E+IL H W  S
Sbjct:    2 VYAGTRVRDGKP--VAIKVIPKNNVYFFEEVGGISVPMEVYLHRVLDH----PNVVRLYDYFEYNQAYVLVLERPTHYRDLFDYITEKKLLSEREAKDIFKQVVHAVAYCEGKGVFHRDIKDENLLLDTKTGQVKLFDFGSGTVLENT---LYTDYEGTRAYCPPEWFRFHRYHARPCTVWSLGILLFNMLSGDVPFANQIEIVRGELNFAENVSKEAQSLVRWLLAKHPSYRPTLENILKHPWLGS 239
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO28459 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6E4])

HSP 1 Score: 58.5362 bits (140), Expect = 3.015e-10
Identity = 38/137 (27.74%), Postives = 61/137 (44.53%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCL--PKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            K GI + DIK ENI+       +++   + S   P  ++     L GT+ YC PE  S   Y  +   +++ GC LY  L  ++ +    Q  N+ L  PK   +D  A EL+++ ++K        E I    W  
Sbjct:   56 KRGILHNDIKPENIL-------LEVEPADKSSKRPRCSERKQSVLTGTMQYCPPEYDSLRTYYRREANVWALGCTLYEMLTGRVAYKGPSQAANQPLQIPKFLSMD--ASELLQKLLEKEAFWRTSLESISQDPWLT 183
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO35437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH0])

HSP 1 Score: 60.077 bits (144), Expect = 3.186e-10
Identity = 41/138 (29.71%), Postives = 68/138 (49.28%), Query Frame = 2 
Query:  479 IFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSK--------AVELIERCIQKNVTKYFRFEDILLHSW 868
            + + DIK EN+++N    DIKI DF  S+++P+S       L GTL Y  PE+   + ++ K   ++S G L Y  L  + PF +E    N    +++ +D +        A +LI + +Q N       + +L H W
Sbjct:  167 VIHRDIKPENLLLN-YKGDIKIADFGWSVHAPSSR---RTTLCGTLDYLPPEMIEGKEHDEK-VDLWSIGVLCYEFLVGKPPFEAEGH--NETYRRISRVDLRFPSHVSPGARDLISKLLQHNPNNRLPLKAVLNHPW 297
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO43241 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZA1])

HSP 1 Score: 57.7658 bits (138), Expect = 4.553e-10
Identity = 38/136 (27.94%), Postives = 61/136 (44.85%), Query Frame = 2 
Query:  470 KHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCL--PKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            K GI + DIK ENI+       +++   + S   P  ++     L GT+ YC PE  S   Y  +   +++ GC LY  L  ++ +    Q  N+ L  PK   +D  A EL+++ ++K        E I    W 
Sbjct:   46 KRGILHNDIKPENIL-------LEVEPADKSSKRPRCSERKQSVLTGTMQYCPPEYDSLRTYYRREANVWALGCTLYEMLTGRVAYKGPSQAANQPLQIPKFLSMD--ACELLQKLLEKEAFWRTSLESISQDPWL 172
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO34707 (Serine/threonine-protein kinase PLK4 [Source:UniProtKB/Swiss-Prot;Acc:A7SNN5])

HSP 1 Score: 58.5362 bits (140), Expect = 2.039e-9
Identity = 42/140 (30.00%), Postives = 72/140 (51.43%), Query Frame = 2 
Query:  473 HGIFYMDIKLENIMVNSVTFDIKIIDF--EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSE--KQTVNRC------LPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLH 862
            HGI + D+ L NI+++S   D KI DF     +  P   D  H  + GT  Y SPE+ + + + ++   ++S GC+L+T L  + PF +E  + T+N+       +P    I+++  +LI + ++KN         IL H
Sbjct:  131 HGIIHRDLSLGNILLSS-DMDAKIADFGLATRLSLP---DEKHYTMCGTPNYISPEIATRDPHGLES-DVWSIGCMLFTLLVGKPPFDTEAVRSTLNKVVLAEYDIPNHVSIEAR--DLISKLLKKNPQDRLTLSGILDH 263
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: pim1 (serine/threonine-protein kinase pim-1 [Source:NCBI gene;Acc:101157054])

HSP 1 Score: 73.9442 bits (180), Expect = 2.620e-14
Identity = 68/260 (26.15%), Postives = 121/260 (46.54%), Query Frame = 2 
Query:  131 SVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEY--SYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDF------EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPF-HSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            +V+ G R+ + + V  K+ ++      +R ++  +      V  E   LK +  TG+   V++ L  FE   S++I+ +  +N K  +DF+ +   + +         +     + H  G+ + DIK ENI+++  T ++K+IDF      +D+IY+            GT  Y  PE     RY  +   ++S G LLY  +   +PF H E+ T  + L +   I ++   LI+ C+    T    FED++ HSW  S
Sbjct:   47 TVYAGTRISDGVPVAVKHVAR------DRVSEWGELPSGARVPMEIVLLKKV-GTGFR-GVIKMLDWFERPDSFIIVMERPENVKDLFDFITERGALPEELARSFFRQVLEAVRHCHSCGVVHRDIKDENILIDLRTGEMKLIDFGSGALLKDTIYT---------DFDGTRVYSPPEWIKYHRYQGRSATVWSLGILLYDMVCGDIPFEHDEEITRGQVLFRRR-ISTECQHLIKWCLSLRPTDRPSFEDVINHSWMQS 288
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000041570.1 (pep primary_assembly:ASM223467v1:10:18938984:18940525:-1 gene:ENSORLG00000023590.1 transcript:ENSORLT00000041570.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.5438 bits (153), Expect = 8.458e-11
Identity = 44/182 (24.18%), Postives = 88/182 (48.35%), Query Frame = 2 
Query:  338 YSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKH--GIFYMDIKLENIMVNSVTFDIKIIDFEDSIY-SPNS-NDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            Y++VI+ +  +N +  Y+++     + +         +    ++ H  G+ +MD+K EN++V+  T ++K+IDF  + +  P+   D +H    GT  Y  PE  +   Y     +++S G LLY  +   +PF ++++ +   L     +    V LI+ C+ +   +    +DIL H W 
Sbjct:  117 YNWVIVTEKPENTQDLYEYITISKRLREDTAREFLGQVIQALLHCHSRGVVHMDVKDENLLVDLTTLELKLIDFGSAEFLEPDKVYDMFH----GTAAYGPPERLTQGCYKALPSEVWSLGILLYDMVHGDIPFGNDRELLLGELRFEKDLSEDCVALIKWCLSRTPEERPMLKDILAHPWM 294
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: pask (PAS domain containing serine/threonine kinase [Source:NCBI gene;Acc:101157160])

HSP 1 Score: 63.1586 bits (152), Expect = 2.296e-10
Identity = 67/248 (27.02%), Postives = 113/248 (45.56%), Query Frame = 2 
Query:  152 VLEAIRVKDKNKSQVIVKCINRKNDI----FDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHIS--XXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDF-EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            V +A+R  D    +VIVK I++   +     DD +   V++E   L  +Q      VV E  ++  Y  ++M+K  D   LF +F+D    +       I + +  A+  +    I + DIK ENI+++   F I++IDF   +I  P           GTL YCSPEV     Y     +++S G LL+T L  + PF   ++ ++  L     + S+   ++   +  N  K    + +LL  W +
Sbjct:  904 VWKAVRRCDGQ--EVIVKFISKARIVSDSWVDDPMLGKVSQEIAILTRVQHHNIVKVV-EVFENGSYFQMVMEKHGDGLDLF-EFIDMQPRLDEPLASYIFRQLVAAVFYLRTKNIIHRDIKDENIIIDKC-FHIRLIDFGSAAILVPGK---LFYNFCGTLEYCSPEVLQGHPYEGPELEMWSLGVLLFTLLFSENPFCDVEEILDAKLKLPFSVSSELHVVLRGLLHSNPKKRMTLDQLLLQPWIS 1143
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000010626.2 (pep primary_assembly:ASM223467v1:12:12000679:12006348:1 gene:ENSORLG00000008461.2 transcript:ENSORLT00000010626.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 61.2326 bits (147), Expect = 4.471e-10
Identity = 35/135 (25.93%), Postives = 68/135 (50.37%), Query Frame = 2 
Query:  476 GIFYMDIKLENIMVNSVTFDIKIIDFEDSIY-SPNSN-DPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            G+ +MD+K EN++++  T  + +IDF  +++  P+   D +H    GT  Y  PE  +   Y     +++S G LLY  +   +PF ++++ +   L     +    V L++ C+ +   +    +DIL H W +
Sbjct:  172 GVVHMDVKDENLLLDPSTHKLLLIDFGSAVFLEPDKVYDTFH----GTAVYAPPERLTQGCYKALPSEVWSLGILLYDMVHGDIPFQNDEEILLGELRFKKDLSEDCVALMQWCLSRAPEERPTLKDILAHPWMS 302
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000032540.1 (serine/threonine-protein kinase pim-2-like [Source:NCBI gene;Acc:101156739])

HSP 1 Score: 60.8474 bits (146), Expect = 5.625e-10
Identity = 35/135 (25.93%), Postives = 68/135 (50.37%), Query Frame = 2 
Query:  476 GIFYMDIKLENIMVNSVTFDIKIIDFEDSIY-SPNS-NDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFN 874
            G+ +MD+K EN++++  T  + +IDF  +++  P+   D +H    GT  Y  PE  +   Y     +++S G LLY  +   +PF ++++ +   L     +    V L++ C+ +   +    +DIL H W +
Sbjct:  146 GVVHMDVKDENLLLDPSTHKLLLIDFGSAVFLEPDKVYDTFH----GTAVYAPPERLTQGCYKALPSEVWSLGILLYDMVHGDIPFQNDEEILLGELRFKKDLSEDCVALMQWCLSRAPEERPTLKDILAHPWMS 276
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000007586.1 (SMESG000007586.1)

HSP 1 Score: 517.309 bits (1331), Expect = 0.000e+0
Identity = 273/277 (98.56%), Postives = 274/277 (98.92%), Query Frame = 2 
Query:   47 MTIVKIFKSSDDHIIYFYYNYKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            MTIVKIFKSSDDHIIYFYYNYKLLKQIQSVFEGNRVLEAIRV DKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISDLKKIIKNIALALIDINKHGIFYMDIKLENIMVNS TFDIKIID EDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERC+QKNVTKYFRFEDILLHSWFNS
Sbjct:    1 MTIVKIFKSSDDHIIYFYYNYKLLKQIQSVFEGNRVLEAIRVNDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISDLKKIIKNIALALIDINKHGIFYMDIKLENIMVNSETFDIKIIDLEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCLQKNVTKYFRFEDILLHSWFNS 277
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000057080.1 (SMESG000057080.1)

HSP 1 Score: 145.591 bits (366), Expect = 1.168e-40
Identity = 89/271 (32.84%), Postives = 147/271 (54.24%), Query Frame = 2 
Query:   65 FKSSDDHIIYFYYNYKLLKQIQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
             +S+++   +F  N+K  + +      N V EA          V+VK +     IFD+  N  VNKE+FFLKLL      P +V Y +  ++  V MKKLS NW +  DF+  V+H +  +K+I+ +   LI + +  ++YMD KL+N+M+N+ T  +K IDFED+I   + ++ +    IGTLGYC+PE+   + Y++   Q F+  C+LYTCLE  + F +E   +    P       KA+ ++++C++ +       + +L   WF S
Sbjct:    7 LESNEEFKTFFTNNFKNTRLLVKENARNIVYEASYPSYVLPPNVVVKILKNNRKIFDEVENREVNKEYFFLKLLSPHNLSPELVVYFEGPKFVGVGMKKLSSNWIVMSDFMKYVHHPNVTRKVIRRVIKLLIKLRELNVYYMDTKLDNLMINNSTLKVKFIDFEDAILLKDPSEMFVRKRIGTLGYCAPEILIDDYYDISKTQTFTIACVLYTCLEKDIAFDTETDLLLTDFPHTYNSPKKAIAIMKKCLKNDPEDRPDLQSLLEMDWFRS 277
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000067222.1 (SMESG000067222.1)

HSP 1 Score: 131.724 bits (330), Expect = 1.684e-35
Identity = 79/241 (32.78%), Postives = 133/241 (55.19%), Query Frame = 2 
Query:  161 AIRVKDKNKSQVIVKCINRKNDI----FDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
             ++  D+    V++K   + +++     +   N ++ KE FFLK L    Y P +++YL    ++ V+M+ L  +W    +F+  +N    +K I++N+   + ++++ G ++ DIK  NIMVN VT ++K+ID ED  Y   S+ P    ++GT+G+ SPE +    YN+K   + + GC+ Y CLELQL F SE +T + C P M +    A   I  CI+ N  +   F D+L H+WF
Sbjct:   29 VMKALDEENKLVLLKTFYKDDELCTFMLEPNFNRFIPKELFFLKHLSKYEYVPKLIKYLDENNWATVVMEYLGGDWMNLGEFLMILNEEKLIKTIMRNLISIIYEMSEIGFYHRDIKPGNIMVNRVTLEVKVIDLEDLFYC-KSDIPTCNSILGTIGFQSPETYCEAPYNLKQSLVCNIGCVAYFCLELQLAFKSEIETFDCCFPDMKMCSELAQSFITDCIKINPKQRIEFNDLLSHAWF 268
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000000218.1 (SMESG000000218.1)

HSP 1 Score: 129.413 bits (324), Expect = 2.301e-34
Identity = 78/216 (36.11%), Postives = 120/216 (55.56%), Query Frame = 2 
Query:  227 IFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSND-PYHIGLIGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWF 871
            I D K N  + KE  FL+ L    Y P +++Y+    +S V+M+ L+ +W    +F  +      +K I+ N+ L + +++  G ++ DIK ENIM+N  TF++K+ID ED +Y  N +D P     +GT+GY SPE+F    YN+K   +F+ GC+ Y CLE Q PF +E +T   CLPKM +    A   I  CI+ +  +   F + L H W 
Sbjct:   74 IEDKKSNRSIPKELLFLEQLSQYEYVPKLIKYIDENNWSTVVMEYLNGDWMNLGEFTMRFADEKLIKIIMINLILIVYEMSDLGYYHRDIKPENIMINRETFEVKLIDLEDVLY--NIDDMPICNSTLGTIGYQSPEIFGDVPYNLKQSLVFNIGCVAYFCLEFQFPFDTEAETRKCCLPKMKVSSELAQSFIANCIKLDPDERIEFGEFLSHQWL 287
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000061880.1 (SMESG000061880.1)

HSP 1 Score: 122.094 bits (305), Expect = 7.911e-32
Identity = 87/269 (32.34%), Postives = 143/269 (53.16%), Query Frame = 2 
Query:   98 YYNYKLLKQ-----IQSVFEGNRVLEAIRVKDKNKSQVIVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSYVIMKKLSDNWKLFYDFVDKVNHISXXXXXXXXXXXXXXXXXKHGIFYMDIKLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGL----IGTLGYCSPEVFSAERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVELIERCIQKNVTKYFRFEDILLHSWFNS 877
            Y+ + +L+Q     + S F+G   L  ++   K     I KC      I D K N  V +E  FL+ L    Y P ++ Y+    +S V+M+ L  +W   +D+  +  + S +K IIKN+ + +  +++ G ++ DIK +NIMVN  T ++K+ID ED ++     D Y I +    +GTLG+ SPE+F    YN+K   + + GC+ Y CLE Q PF+S+ +T    LPK+ +    A   I  CI+ +  +   F D+L H+W ++
Sbjct:   15 YHEFIVLQQSCKGIVMSAFDGENKLVLLKTFYK-----IKKCFTF---IVDKKSNRSVPRELLFLEQLSQYEYVPKLITYIDENNWSTVVMEYLDGDWMDLHDYTMQFPYESPIKTIIKNLIIIVYKMSEIGYYHRDIKPKNIMVNEETLEVKLIDLEDVLF-----DQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCNIGCVAYFCLEFQFPFNSKIETKKCNLPKINLSSDLARSFITDCIKPDPDERIEFGDLLFHNWLDN 270
The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PIM26.549e-1023.92Pim-2 proto-oncogene, serine/threonine kinase [Sou... [more]
RPS6KA57.486e-1026.02ribosomal protein S6 kinase A5 [Source:HGNC Symbol... [more]
RPS6KA58.824e-1026.02ribosomal protein S6 kinase A5 [Source:HGNC Symbol... [more]
PIM31.579e-920.32Pim-3 proto-oncogene, serine/threonine kinase [Sou... [more]
PIM11.934e-823.02Pim-1 proto-oncogene, serine/threonine kinase [Sou... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prk-15.141e-1228.78Pim (Mammalian oncogene) Related Kinase [Source:U... [more]
prk-11.340e-1128.78Pim (Mammalian oncogene) Related Kinase [Source:U... [more]
prk-11.649e-1128.78Pim (Mammalian oncogene) Related Kinase [Source:U... [more]
prk-25.070e-1030.60Serine/threonine-protein kinase prk-2 [Source:Uni... [more]
prk-25.070e-1030.60Serine/threonine-protein kinase prk-2 [Source:Uni... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Gprk23.521e-1033.61gene:FBgn0261988 transcript:FBtr0334555[more]
Gprk23.521e-1033.61gene:FBgn0261988 transcript:FBtr0085788[more]
SAK3.333e-829.08gene:FBgn0026371 transcript:FBtr0078387[more]
CaMKII2.404e-727.59gene:FBgn0264607 transcript:FBtr0333673[more]
CaMKII2.429e-727.59gene:FBgn0264607 transcript:FBtr0300377[more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pimr706.560e-1825.19Pim proto-oncogene, serine/threonine kinase, relat... [more]
pimr744.159e-1725.09Pim proto-oncogene, serine/threonine kinase, relat... [more]
pimr721.234e-1624.81Pim proto-oncogene, serine/threonine kinase, relat... [more]
si:dkey-58i8.54.265e-1630.88si:dkey-58i8.5 [Source:ZFIN;Acc:ZDB-GENE-160728-66... [more]
pimr1851.085e-1526.38Pim proto-oncogene, serine/threonine kinase, relat... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ncbp13.850e-1021.83nuclear cap binding protein subunit 1 [Source:Xenb... [more]
ncbp16.433e-1021.83nuclear cap binding protein subunit 1 [Source:Xenb... [more]
pus7l7.214e-1027.42pseudouridine synthase 7 like [Source:Xenbase;Acc:... [more]
pus7l8.407e-1027.42pseudouridine synthase 7 like [Source:Xenbase;Acc:... [more]
pus7l8.629e-1026.98pseudouridine synthase 7 like [Source:Xenbase;Acc:... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pim31.970e-1020.32proviral integration site 3 [Source:MGI Symbol;Acc... [more]
Pim22.792e-1023.74proviral integration site 2 [Source:MGI Symbol;Acc... [more]
Pim23.210e-1023.74proviral integration site 2 [Source:MGI Symbol;Acc... [more]
Rps6ka51.398e-925.00ribosomal protein S6 kinase, polypeptide 5 [Source... [more]
Pim11.621e-926.87proviral integration site 1 [Source:MGI Symbol;Acc... [more]
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BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q93VK0|PPCK2_ARATH2.861e-1129.08Phosphoenolpyruvate carboxylase kinase 2 OS=Arabid... [more]
sp|Q9UTH3|PPK6_SCHPO5.634e-1025.79Serine/threonine-protein kinase ppk6 OS=Schizosacc... [more]
sp|O70444|PIM3_RAT9.048e-1020.32Serine/threonine-protein kinase pim-3 OS=Rattus no... [more]
sp|P58750|PIM3_MOUSE1.378e-920.32Serine/threonine-protein kinase pim-3 OS=Mus muscu... [more]
sp|Q08217|PSK2_YEAST1.501e-929.63Serine/threonine-protein kinase PSK2 OS=Saccharomy... [more]
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BLAST of Serine/threonine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2P1ERR94.323e-2833.65PIM-1-like protein OS=Schmidtea mediterranea OX=79... [more]
F1QR201.468e-1425.19Pim proto-oncogene, serine/threonine kinase,-relat... [more]
A0A146IAN32.492e-1432.62Protein kinase domain-containing protein OS=Mycena... [more]
A0A1C7NG279.275e-1427.24Serine/threonine-protein kinase ppk6 OS=Choanephor... [more]
F1QRN59.307e-1425.09Pim proto-oncogene, serine/threonine kinase,-relat... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000012249.21.290e-1434.53pep primary_assembly:Astyanax_mexicanus-2.0:10:901... [more]
ENSAMXT00000005084.21.972e-1434.53pep primary_assembly:Astyanax_mexicanus-2.0:10:901... [more]
ENSAMXT00000042000.14.302e-1432.84pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000030133.16.292e-1429.63serine/threonine-protein kinase pim-3-like [Source... [more]
ENSAMXT00000032916.11.352e-1329.66serine/threonine-protein kinase pim-2-like [Source... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rps6ka59.513e-1026.26ribosomal protein S6 kinase, polypeptide 5 [Source... [more]
GRK51.763e-936.17G protein-coupled receptor kinase 5 [Source:HGNC S... [more]
ENSPMAT00000003384.12.840e-925.84pep scaffold:Pmarinus_7.0:GL476716:1230:12573:1 ge... [more]
ENSPMAT00000008748.15.906e-827.59pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 ge... [more]
camk2a6.058e-827.97calcium/calmodulin-dependent protein kinase II alp... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
PSK22.161e-1129.63PAS-domain containing serine/threonine protein kin... [more]
PSK19.569e-1133.07PAS domain-containing serine/threonine protein kin... [more]
IPL12.221e-829.58Aurora kinase of chromosomal passenger complex; me... [more]
KIN23.037e-827.78Serine/threonine protein kinase involved in regula... [more]
PKH11.470e-732.67Serine/threonine protein kinase; involved in sphin... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO468615.744e-1725.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO284593.015e-1027.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354373.186e-1029.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO432414.553e-1027.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO347072.039e-930.00Serine/threonine-protein kinase PLK4 [Source:UniP... [more]
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BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pim12.620e-1426.15serine/threonine-protein kinase pim-1 [Source:NCBI... [more]
ENSORLT00000041570.18.458e-1124.18pep primary_assembly:ASM223467v1:10:18938984:18940... [more]
pask2.296e-1027.02PAS domain containing serine/threonine kinase [Sou... [more]
ENSORLT00000010626.24.471e-1025.93pep primary_assembly:ASM223467v1:12:12000679:12006... [more]
ENSORLT00000032540.15.625e-1025.93serine/threonine-protein kinase pim-2-like [Source... [more]
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BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000007586.10.000e+098.56SMESG000007586.1[more]
SMESG000057080.11.168e-4032.84SMESG000057080.1[more]
SMESG000067222.11.684e-3532.78SMESG000067222.1[more]
SMESG000000218.12.301e-3436.11SMESG000000218.1[more]
SMESG000061880.17.911e-3232.34SMESG000061880.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005365 ID=SMED30005365|Name=Serine/threonine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1109bp
TTAACTTGTGGTTTTCAGGTATTTTTACCAATTTATTTTCATTTAAATGA
CAATTGTAAAAATTTTTAAATCTTCTGATGATCATATCATATATTTTTAC
TATAATTATAAATTGCTGAAACAAATTCAAAGTGTTTTTGAAGGTAATCG
AGTCTTAGAAGCAATCCGAGTAAAAGATAAAAATAAATCTCAAGTTATTG
TTAAATGTATAAATAGAAAGAATGATATTTTTGATGATAAGCTTAATTTA
TATGTTAATAAAGAGTTTTTCTTTTTGAAATTATTGCAGGCTACTGGATA
TTGTCCGGTTGTTGTTGAATATTTACAGAGTTTTGAATATTCCTATGTTA
TAATGAAAAAGTTATCTGATAATTGGAAATTATTTTATGATTTTGTTGAC
AAAGTAAATCATATAAGTGATTTAAAGAAAATAATTAAGAATATCGCTTT
AGCATTGATTGACATTAATAAACATGGAATTTTCTACATGGATATCAAAC
TAGAAAATATTATGGTTAATTCAGTAACATTTGATATTAAAATTATTGAT
TTTGAAGATTCTATTTATTCTCCAAATTCTAATGATCCTTATCACATTGG
ATTAATTGGGACTTTAGGGTATTGTAGTCCAGAAGTCTTTTCAGCAGAAC
GTTATAACGTTAAATGTTGTCAGATTTTTAGCTTTGGTTGTTTGTTATAT
ACTTGTTTGGAGTTGCAGTTACCTTTTCATAGTGAAAAACAAACGGTTAA
TCGTTGTCTTCCAAAAATGACTATAATAGACAGTAAAGCAGTTGAATTAA
TTGAAAGGTGCATACAAAAAAATGTTACTAAATATTTTAGATTTGAAGAC
ATTCTTCTACATAGTTGGTTTAATTCGTGATATGTATAGAACAGTGTCTT
ATGCATTTTGAATCAAAACTTTTGATAATACAGTTTTTTGAAACGGTTTA
AATCGTTGTATATATCGAATCTAGATAAGGTTCTTATGATACATATTTTG
AATAGCTATCTCGATACTCTGTAATATTTATCAAGATAAACAAATTTGAT
GGCATTTAATGTAATTTATAGAATTGAAAGTTGGATAAAAAGTGAGTTAT
TGTTTCGTA
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protein sequence of SMED30005365-orf-1

>SMED30005365-orf-1 ID=SMED30005365-orf-1|Name=SMED30005365-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=278bp
MTIVKIFKSSDDHIIYFYYNYKLLKQIQSVFEGNRVLEAIRVKDKNKSQV
IVKCINRKNDIFDDKLNLYVNKEFFFLKLLQATGYCPVVVEYLQSFEYSY
VIMKKLSDNWKLFYDFVDKVNHISDLKKIIKNIALALIDINKHGIFYMDI
KLENIMVNSVTFDIKIIDFEDSIYSPNSNDPYHIGLIGTLGYCSPEVFSA
ERYNVKCCQIFSFGCLLYTCLELQLPFHSEKQTVNRCLPKMTIIDSKAVE
LIERCIQKNVTKYFRFEDILLHSWFNS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016740transferase activity
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0016301kinase activity
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0043066negative regulation of apoptotic process
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000429neoblast
PLANA:0000478pharynx musculature
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 24..275
e-value: 1.8E-13
score: 59.4
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 42..275
e-value: 1.6E-25
score: 89.9
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 21..275
score: 18.676
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 18..277
e-value: 5.2E-33
score: 116.5
NoneNo IPR availablePANTHERPTHR24347:SF412CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE Icoord: 35..276
NoneNo IPR availablePANTHERPTHR24347SERINE/THREONINE-PROTEIN KINASEcoord: 35..276
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 145..157
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 18..276