HECT and RLD domain containing E3 ubiquitin protein ligase 4

Overview
NameHECT and RLD domain containing E3 ubiquitin protein ligase 4
Smed IDSMED30005288
Length (bp)3448
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (SMED30005288) t-SNE clustered cells

Violin plots show distribution of expression levels for HECT and RLD domain containing E3 ubiquitin protein ligase 4 (SMED30005288) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (SMED30005288) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HECT and RLD domain containing E3 ubiquitin protein ligase 4 (SMED30005288) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30005288

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
Category 2 cellSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30005288SMESG000033113.1 KP954684smed_ncbi_20200123PMID:25956527
Henderson et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Match: HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:HGNC Symbol;Acc:HGNC:24521])

HSP 1 Score: 645.195 bits (1663), Expect = 0.000e+0
Identity = 398/1080 (36.85%), Postives = 602/1080 (55.74%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-----VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G AS+GQLG+   +++    P+K D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ +K+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V++I CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W P        I     +E+ + VKR++ GG+ S    SS  +CG    PDD R        N T     VNE +   + S  + +   E+        SSS   +  S   +S  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++  S     I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   +II Y+ FYI ++ ++ D+   Y  W++      ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL +K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     + YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWYPYNGQCLPDID----SEEYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------PNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 1049          

HSP 2 Score: 90.8929 bits (224), Expect = 8.627e-18
Identity = 57/185 (30.81%), Postives = 96/185 (51.89%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLG 613
            +  + + K   +F +G   YGQLG+    K   S PQ +  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + ++ACG  HT A   +S  I+S+G    GQLG G
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330          

HSP 3 Score: 55.4546 bits (132), Expect = 7.239e-7
Identity = 39/135 (28.89%), Postives = 71/135 (52.59%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHD--CNKVKPNQIQMLDAHKLIDASAGYDH-NAVVTNLGLVFTWGKNSFGELG----RDKLSDFSIK 484
            +IF +G   +GQLG++  N  Y   P  +  + S  I  I CG DHT  L K G +++ G   + +LGH+   +++ P ++  L    + + + G  H +A V + G ++++G    G+LG     ++ S F++K
Sbjct:  210 AIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Match: HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:HGNC Symbol;Acc:HGNC:24521])

HSP 1 Score: 642.499 bits (1656), Expect = 0.000e+0
Identity = 399/1088 (36.67%), Postives = 601/1088 (55.24%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELW-------------LRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G AS+GQLG+   +++    P+K D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ +K+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V++I CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W P        I     +E+ + VKR++ GG+ S    SS  +CG    PDD R        N T     VNE +   + S  + +   E+        SSS   +  S   +S  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++  S     I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   +II Y+ FYI ++ ++ D+   Y  W             L  ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL +K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     + YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWYPYNGQCLPDID----SEEYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------PNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 1057          

HSP 2 Score: 90.8929 bits (224), Expect = 8.814e-18
Identity = 57/185 (30.81%), Postives = 96/185 (51.89%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLG 613
            +  + + K   +F +G   YGQLG+    K   S PQ +  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + ++ACG  HT A   +S  I+S+G    GQLG G
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330          

HSP 3 Score: 55.4546 bits (132), Expect = 7.568e-7
Identity = 39/135 (28.89%), Postives = 71/135 (52.59%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHD--CNKVKPNQIQMLDAHKLIDASAGYDH-NAVVTNLGLVFTWGKNSFGELG----RDKLSDFSIK 484
            +IF +G   +GQLG++  N  Y   P  +  + S  I  I CG DHT  L K G +++ G   + +LGH+   +++ P ++  L    + + + G  H +A V + G ++++G    G+LG     ++ S F++K
Sbjct:  210 AIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Match: AC098582.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:8916])

HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0
Identity = 378/1058 (35.73%), Postives = 595/1058 (56.24%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE-FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S GQ GI    +   + PQ    IS   +++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA++ S+G +YAFG G  GQLG   T  +     P+ G+W      +  ++S      + +IVK+++ GG+ + +  S  +        D R  N  H T+      I V    ++E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +  +SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W   + P+YF K   ++  A+   + G +       F++ I        L KL+++N     +  Y+TFYIP+I  + D++  Y +W  + + ++  +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR+NL+GD + +L   +   LKK  +V F GE+A+D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K  L+DL EL+PT G+SLQ LLDY   D E+ F LNF +  E YG   + +LI  G +  V   NRQ +VD YV+Y+   +V + +  F  GF     GK L+ F+P EL+ +MVG+ +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GM+ ++I IQ     + YLPVAHTCYNLLDLPKY+S+ IL  +L  A++N EGF+L 
Sbjct:    1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNV-KCPSPVKGYWAA----HSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAV--DFRTMNQAHYTSLINDETIAVWRQKLSE--HNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYI--TAALKLLEKLYKVNLKVKHV-EYDTFYIPEISNLVDIQEDYLMWFLHQAGMDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1042          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Match: HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:4876])

HSP 1 Score: 617.846 bits (1592), Expect = 0.000e+0
Identity = 378/1066 (35.46%), Postives = 595/1066 (55.82%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---------FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S GQ GI    +   + PQ    IS   +++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA++ S+G +YAFG G  GQLG   T  +     P+ G+W      +  ++S      + +IVK+++ GG+ + +  S  +        D R  N  H T+      I V    ++E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +  +SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W   + P+YF K   ++  A+   + G +       F++ I        L KL+++N     +  Y+TFYIP+I  + D++  Y +W  + + ++          +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR+NL+GD + +L   +   LKK  +V F GE+A+D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K  L+DL EL+PT G+SLQ LLDY   D E+ F LNF +  E YG   + +LI  G +  V   NRQ +VD YV+Y+   +V + +  F  GF     GK L+ F+P EL+ +MVG+ +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GM+ ++I IQ     + YLPVAHTCYNLLDLPKY+S+ IL  +L  A++N EGF+L 
Sbjct:    1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNV-KCPSPVKGYWAA----HSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAV--DFRTMNQAHYTSLINDETIAVWRQKLSE--HNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYI--TAALKLLEKLYKVNLKVKHV-EYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1050          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Match: HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:4876])

HSP 1 Score: 617.846 bits (1592), Expect = 0.000e+0
Identity = 378/1066 (35.46%), Postives = 595/1066 (55.82%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---------FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S GQ GI    +   + PQ    IS   +++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA++ S+G +YAFG G  GQLG   T  +     P+ G+W      +  ++S      + +IVK+++ GG+ + +  S  +        D R  N  H T+      I V    ++E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +  +SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W   + P+YF K   ++  A+   + G +       F++ I        L KL+++N     +  Y+TFYIP+I  + D++  Y +W  + + ++          +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR+NL+GD + +L   +   LKK  +V F GE+A+D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K  L+DL EL+PT G+SLQ LLDY   D E+ F LNF +  E YG   + +LI  G +  V   NRQ +VD YV+Y+   +V + +  F  GF     GK L+ F+P EL+ +MVG+ +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GM+ ++I IQ     + YLPVAHTCYNLLDLPKY+S+ IL  +L  A++N EGF+L 
Sbjct:    1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNV-KCPSPVKGYWAA----HSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAV--DFRTMNQAHYTSLINDETIAVWRQKLSE--HNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYI--TAALKLLEKLYKVNLKVKHV-EYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1050          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72])

HSP 1 Score: 469.159 bits (1206), Expect = 2.666e-147
Identity = 331/1036 (31.95%), Postives = 520/1036 (50.19%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCN-----KVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDF--SIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNN-FENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK----HPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFF----SSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEIS---EFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDL--EYSYELWLRNVSKIEFSLFD-YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSF---------------HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYIL----NKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            CG  HT+FL K+GK++S G+N   +LG          + P  +    + K+I  SAG  H   VT+ G VF WG N  G+LG +    +  + + VQ +    IVQVA G +H +AL +   +F WG    G+         +  P+ ++ LS +PI  + AG +    L+ SG +++WG NN G+LG D      S+   V  +    +V  + G NH   L+  G  F++G    GQ G     E ++ P  V DL+GS V++I  G  HT+A  +  G  Y FGL   GQLG             I     P + +    ++G           R  G    + I   S  C  + YP  L   + K        + VM++   E +++S+++M                   + + +V    + +HG+++D    +M  F           Y++ +   +K    +  +++ N   +ECLR  L+     I   +   +  K +  PF  +  +I      AL KW   L  R+F++   VF  AI   +   +G     KF  I++         KL  IN+ ++ II   TFYI ++    DL  EY  EL  ++ +K E   +  +PFL +G+ K  L+ +EA  + +        QSS                 +TVRR+ ++ DT++Q+   ++  L+K  +VN  GEDA D GGV KE F+LV+ ++L  DYG+F    ES L WF+ +  +  +  QF+ +GRL GL+IYN+ ++   FPL ++K LL+   +L+DL EL+P+ GK L++LL Y+++D ED+F LNF +S    G     EL+  G +KPVT +NR  YV LYV + L    N  + Q    F++GF  ++  + L+FF+P EL+E++VG+E+YDW   R    Y GEY ++H  I  FW +F +L+ DE++KFL++LTG  R+P++G  ++   IQP   +   LPVAHTC+NLLDLP    +  L  +L+I+IE+ EGF L 
Sbjct:   48 CGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYP--VSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEIND--IVQVASGSNHCIALDEGGRVFVWGEQADGRC--------IHRPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQ-HVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIA--ICKGAPYPFGLNSSGQLG----------NGKIMTQSTPRKTDELDHVTGVFAGYHQTFFVRSSGTIEQNEIVGPS--CPMQ-YPIKLDHESLKKLLDEGDALEVMSL--IESVFSSLASMN-----------MSFLYKDERRYNVGFCFERSHGIDMD---QVMEAFMLFDEYPMKRQYMELIVDSLK---IAFQEWSENLKGIECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQ---------KLSLINKTYH-IIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQT-----LRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES--LPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA 1019          

HSP 2 Score: 108.612 bits (270), Expect = 1.283e-23
Identity = 72/229 (31.44%), Postives = 115/229 (50.22%), Query Frame = 2
Query:  428 GKNSFGELGRDKLSDFSIKLVQSLTGH-------FIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICD 1093
            G    G+LG  +LS+ +I++ + + G         +  V CG  HT+ LTK+ +++S G+N  GQLG G   +   +   +   S+  I  I+AG   +  +T  G +++WGSN +GQLG +   +++  P  V+ +    IV V+ G NH  AL   G VF WG    G+  H        P  V  L G  + ++  G  H LA + ++G V+ +G    G+LGI D
Sbjct:    9 GHTGEGQLGV-RLSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEIND--IVQVASGSNHCIALDEGGRVFVWGEQADGRCIHR-------PEPVEQLSGVPIVRVLAGARHCLA-LSASGAVFTWGQNNSGELGIDD 226          

HSP 3 Score: 99.3673 bits (246), Expect = 9.442e-21
Identity = 63/222 (28.38%), Postives = 112/222 (50.45%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG 766
            +F++G+  +GQLG++ +   +   P+++ +I+         G +H + L + G+++  G     +  H     +P  ++ L    ++   AG  H   ++  G VFTWG+N+ GELG D L    S++ V  + G  +V+ ACG +HT+ LT     FS+G++  GQ G G   +  + P  + +L    +  I AG   +  +   G  Y +G N+ GQLG
Sbjct:  115 VFAWGSNEHGQLGMESKFT-WQGTPRRVQEINDIVQVA--SGSNHCIALDEGGRVFVWGEQADGRCIH-----RPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQHVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAIC-KGAPYPFGLNSSGQLG 327          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72])

HSP 1 Score: 469.159 bits (1206), Expect = 2.666e-147
Identity = 331/1036 (31.95%), Postives = 520/1036 (50.19%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCN-----KVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDF--SIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNN-FENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK----HPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFF----SSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEIS---EFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDL--EYSYELWLRNVSKIEFSLFD-YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSF---------------HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYIL----NKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            CG  HT+FL K+GK++S G+N   +LG          + P  +    + K+I  SAG  H   VT+ G VF WG N  G+LG +    +  + + VQ +    IVQVA G +H +AL +   +F WG    G+         +  P+ ++ LS +PI  + AG +    L+ SG +++WG NN G+LG D      S+   V  +    +V  + G NH   L+  G  F++G    GQ G     E ++ P  V DL+GS V++I  G  HT+A  +  G  Y FGL   GQLG             I     P + +    ++G           R  G    + I   S  C  + YP  L   + K        + VM++   E +++S+++M                   + + +V    + +HG+++D    +M  F           Y++ +   +K    +  +++ N   +ECLR  L+     I   +   +  K +  PF  +  +I      AL KW   L  R+F++   VF  AI   +   +G     KF  I++         KL  IN+ ++ II   TFYI ++    DL  EY  EL  ++ +K E   +  +PFL +G+ K  L+ +EA  + +        QSS                 +TVRR+ ++ DT++Q+   ++  L+K  +VN  GEDA D GGV KE F+LV+ ++L  DYG+F    ES L WF+ +  +  +  QF+ +GRL GL+IYN+ ++   FPL ++K LL+   +L+DL EL+P+ GK L++LL Y+++D ED+F LNF +S    G     EL+  G +KPVT +NR  YV LYV + L    N  + Q    F++GF  ++  + L+FF+P EL+E++VG+E+YDW   R    Y GEY ++H  I  FW +F +L+ DE++KFL++LTG  R+P++G  ++   IQP   +   LPVAHTC+NLLDLP    +  L  +L+I+IE+ EGF L 
Sbjct:   48 CGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYP--VSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEIND--IVQVASGSNHCIALDEGGRVFVWGEQADGRC--------IHRPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQ-HVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIA--ICKGAPYPFGLNSSGQLG----------NGKIMTQSTPRKTDELDHVTGVFAGYHQTFFVRSSGTIEQNEIVGPS--CPMQ-YPIKLDHESLKKLLDEGDALEVMSL--IESVFSSLASMN-----------MSFLYKDERRYNVGFCFERSHGIDMD---QVMEAFMLFDEYPMKRQYMELIVDSLK---IAFQEWSENLKGIECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQ---------KLSLINKTYH-IIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQT-----LRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES--LPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA 1019          

HSP 2 Score: 108.612 bits (270), Expect = 1.283e-23
Identity = 72/229 (31.44%), Postives = 115/229 (50.22%), Query Frame = 2
Query:  428 GKNSFGELGRDKLSDFSIKLVQSLTGH-------FIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICD 1093
            G    G+LG  +LS+ +I++ + + G         +  V CG  HT+ LTK+ +++S G+N  GQLG G   +   +   +   S+  I  I+AG   +  +T  G +++WGSN +GQLG +   +++  P  V+ +    IV V+ G NH  AL   G VF WG    G+  H        P  V  L G  + ++  G  H LA + ++G V+ +G    G+LGI D
Sbjct:    9 GHTGEGQLGV-RLSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMWSVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEIND--IVQVASGSNHCIALDEGGRVFVWGEQADGRCIHR-------PEPVEQLSGVPIVRVLAGARHCLA-LSASGAVFTWGQNNSGELGIDD 226          

HSP 3 Score: 99.3673 bits (246), Expect = 9.442e-21
Identity = 63/222 (28.38%), Postives = 112/222 (50.45%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG 766
            +F++G+  +GQLG++ +   +   P+++ +I+         G +H + L + G+++  G     +  H     +P  ++ L    ++   AG  H   ++  G VFTWG+N+ GELG D L    S++ V  + G  +V+ ACG +HT+ LT     FS+G++  GQ G G   +  + P  + +L    +  I AG   +  +   G  Y +G N+ GQLG
Sbjct:  115 VFAWGSNEHGQLGMESKFT-WQGTPRRVQEINDIVQVA--SGSNHCIALDEGGRVFVWGEQADGRCIH-----RPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQHVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAIC-KGAPYPFGLNSSGQLG 327          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72])

HSP 1 Score: 331.257 bits (848), Expect = 5.197e-100
Identity = 212/606 (34.98%), Postives = 335/606 (55.28%), Query Frame = 2
Query: 1466 QTNHGLNIDLTFNIMSQFF----SSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEIS---EFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDL--EYSYELWLRNVSKIEFSLFD-YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSS----------FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMI--FDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYIL----NKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            + +HG+++D    +M  F           Y++ +   +K    +  +++ N   +ECLR  L+     I   +   +  K +  PF  +  +I      AL KW   L  R+F++   VF  AI   +   +G     KF  I++         KL  IN+ ++ II   TFYI ++    DL  EY  EL  ++ +K E   +  +PFL +G+ K  L+ +EA  + +      +  ++            +TVRR+ ++ DT++Q+   ++  L+K  +VN  GEDA D GGV KE F+LV+ ++L  DYG+F    ES L WF+ +   F D   QF+ +GRL GL+IYN+ ++   FPL ++K LL+   +L+DL EL+P+ GK L++LL Y+++D ED+F LNF +S    G     EL+  G +KPVT +NR  YV LYV + L    N  + Q    F++GF  ++  + L+FF+P EL+E++VG+E+YDW   R    Y GEY ++H  I  FW +F +L+ DE++KFL++LTG  R+P++G  ++   IQP   +   LPVAHTC+NLLDLP    +  L  +L+I+IE+ EGF L 
Sbjct:   57 ERSHGIDMD---QVMEAFMLFDEYPMKRQYMELIVDSLK---IAFQEWSENLKGIECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQ---------KLSLINKTYH-IIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDR-EQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES--LPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA 643          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72])

HSP 1 Score: 332.028 bits (850), Expect = 8.178e-100
Identity = 215/611 (35.19%), Postives = 335/611 (54.83%), Query Frame = 2
Query: 1466 QTNHGLNIDLTFNIMSQFF----SSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEIS---EFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDL--EYSYELWLRNVSKIEFSLFD-YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSF---------------HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMI--FDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYIL----NKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            + +HG+++D    +M  F           Y++ +   +K    +  +++ N   +ECLR  L+     I   +   +  K +  PF  +  +I      AL KW   L  R+F++   VF  AI   +   +G     KF  I++         KL  IN+ ++ II   TFYI ++    DL  EY  EL  ++ +K E   +  +PFL +G+ K  L+ +EA  + +        QSS                 +TVRR+ ++ DT++Q+   ++  L+K  +VN  GEDA D GGV KE F+LV+ ++L  DYG+F    ES L WF+ +   F D   QF+ +GRL GL+IYN+ ++   FPL ++K LL+   +L+DL EL+P+ GK L++LL Y+++D ED+F LNF +S    G     EL+  G +KPVT +NR  YV LYV + L    N  + Q    F++GF  ++  + L+FF+P EL+E++VG+E+YDW   R    Y GEY ++H  I  FW +F +L+ DE++KFL++LTG  R+P++G  ++   IQP   +   LPVAHTC+NLLDLP    +  L  +L+I+IE+ EGF L 
Sbjct:  102 ERSHGIDMD---QVMEAFMLFDEYPMKRQYMELIVDSLK---IAFQEWSENLKGIECLRVLLMLPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQ---------KLSLINKTYH-IIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQT-----LRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDR-EQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES--LPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA 688          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Match: herc-1 (HECT and RCC domain E3 ubiquitin ligase [Source:UniProtKB/TrEMBL;Acc:W6RY72])

HSP 1 Score: 323.553 bits (828), Expect = 7.034e-99
Identity = 197/512 (38.48%), Postives = 296/512 (57.81%), Query Frame = 2
Query: 1742 ALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDL--EYSYELWLRNVSKIEFSLFD-YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSF---------------HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMI--FDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYIL----NKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            AL KW   L  R+F++   VF  AI   +   +G     KF  I++         KL  IN+ ++ II   TFYI ++    DL  EY  EL  ++ +K E   +  +PFL +G+ K  L+ +EA  + +        QSS                 +TVRR+ ++ DT++Q+   ++  L+K  +VN  GEDA D GGV KE F+LV+ ++L  DYG+F    ES L WF+ +   F D   QF+ +GRL GL+IYN+ ++   FPL ++K LL+   +L+DL EL+P+ GK L++LL Y+++D ED+F LNF +S    G     EL+  G +KPVT +NR  YV LYV + L    N  + Q    F++GF  ++  + L+FF+P EL+E++VG+E+YDW   R    Y GEY ++H  I  FW +F +L+ DE++KFL++LTG  R+P++G  ++   IQP   +   LPVAHTC+NLLDLP    +  L  +L+I+IE+ EGF L 
Sbjct:   11 ALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQ---------KLSLINKTYH-IIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQT-----LRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDR-EQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPES--LPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA 504          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072670)

HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0
Identity = 361/1066 (33.86%), Postives = 577/1066 (54.13%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGR--DKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVST--PQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKH-----PTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNR--NYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYF----KKFCMVFINAINNEINGFEGQNTKKKFSDII----EMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFH-------------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            ++ +G+ S+GQLG+     +    P +I     + +++++CG  HTLFL   GK+Y+CG+N++ +LGHD    +P  I  L  + +I    G  H+  +++ G V +WG N  G+LG   DK      K+V+ L    +VQ+ACG++H+LALT   E++SWG+N  GQLG+    D+     P ++  L  +P+ +I  G   SF+++ SG ++ WG NN GQLG +  T+  S P  +K LR   + +V+ G      L+ +GGVFT G G YGQLGH    N+ +P +VM+L+GS ++Q+ CG  HTLA + S G VYAFGLG  GQLG   T  +    + + G WV     + S +     ++   ++++++ GG+ SI+T +      KV P+D R +N K         +T       + + + +  + SI  +  S      S  LD  +  F  S  NHGL++           + ++    Q +     DNI  ++  +   +   +E +R +L+  +      S+  K + +PF+ +   + E P   LNKW+      YF    + F  V I+ I+ ++       + ++   ++    E++ +   +  L QIN + +  ++Y  FY P +    D++  Y  W+   +  +F++ +Y F+FD   KT L++ +    M   +       +F              + V R+NL+ D++ +L   +Q  LKK  ++ F GE+A D GGV KE F+L++  +L+P YG+F+ Y +SRL WF  + F+     F  IG L GLAIYN  +I+L FPL +FKKLL +  +L DL +L+P    S+Q LLDY  +DF+++F L F +S + +G      L  +G +  VTL NRQ +VDLYVD++ NK+VE  +  F +GF     G+ +  F+P EL  ++VG+E YDW  L+ +CEY   Y +    I WFW     +S  EKK FL +LTG DR+PI GM  +K+ IQP   D+ +LPVAHTC+NLLDLP+Y ++  L+ KL  AI+  +GF+LV
Sbjct:    7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETN-RSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLM-LPQVVIGPWV---SPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFV--DKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLD-HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIW----DNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMQAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1058          

HSP 2 Score: 124.79 bits (312), Expect = 1.961e-28
Identity = 70/195 (35.90%), Postives = 106/195 (54.36%), Query Frame = 2
Query:  551 LTKNSEIFSWGANTCGQLGLGDNFD-MVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGH-NNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPIN 1129
            +    E++ WG+ + GQLGLG   D  + TP QI    +  ++ +  G + +  LT +G +Y+ GSN+Y QLG DL T     PL++  L+   I+ +  G  H  ALS  G V +WG    GQLGH  + E   +P +V  L+   V QI CG NH+LA + S G +Y++G   +GQLG+    ++ H   P+ 
Sbjct:    1 MASGKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR---PLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLA-LTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLR 191          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0072671)

HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0
Identity = 361/1066 (33.86%), Postives = 577/1066 (54.13%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGR--DKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVST--PQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKH-----PTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNR--NYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYF----KKFCMVFINAINNEINGFEGQNTKKKFSDII----EMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFH-------------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            ++ +G+ S+GQLG+     +    P +I     + +++++CG  HTLFL   GK+Y+CG+N++ +LGHD    +P  I  L  + +I    G  H+  +++ G V +WG N  G+LG   DK      K+V+ L    +VQ+ACG++H+LALT   E++SWG+N  GQLG+    D+     P ++  L  +P+ +I  G   SF+++ SG ++ WG NN GQLG +  T+  S P  +K LR   + +V+ G      L+ +GGVFT G G YGQLGH    N+ +P +VM+L+GS ++Q+ CG  HTLA + S G VYAFGLG  GQLG   T  +    + + G WV     + S +     ++   ++++++ GG+ SI+T +      KV P+D R +N K         +T       + + + +  + SI  +  S      S  LD  +  F  S  NHGL++           + ++    Q +     DNI  ++  +   +   +E +R +L+  +      S+  K + +PF+ +   + E P   LNKW+      YF    + F  V I+ I+ ++       + ++   ++    E++ +   +  L QIN + +  ++Y  FY P +    D++  Y  W+   +  +F++ +Y F+FD   KT L++ +    M   +       +F              + V R+NL+ D++ +L   +Q  LKK  ++ F GE+A D GGV KE F+L++  +L+P YG+F+ Y +SRL WF  + F+     F  IG L GLAIYN  +I+L FPL +FKKLL +  +L DL +L+P    S+Q LLDY  +DF+++F L F +S + +G      L  +G +  VTL NRQ +VDLYVD++ NK+VE  +  F +GF     G+ +  F+P EL  ++VG+E YDW  L+ +CEY   Y +    I WFW     +S  EKK FL +LTG DR+PI GM  +K+ IQP   D+ +LPVAHTC+NLLDLP+Y ++  L+ KL  AI+  +GF+LV
Sbjct:    7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETN-RSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLM-LPQVVIGPWV---SPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFV--DKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLD-HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIW----DNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMQAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1058          

HSP 2 Score: 124.79 bits (312), Expect = 1.961e-28
Identity = 70/195 (35.90%), Postives = 106/195 (54.36%), Query Frame = 2
Query:  551 LTKNSEIFSWGANTCGQLGLGDNFD-MVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGH-NNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPIN 1129
            +    E++ WG+ + GQLGLG   D  + TP QI    +  ++ +  G + +  LT +G +Y+ GSN+Y QLG DL T     PL++  L+   I+ +  G  H  ALS  G V +WG    GQLGH  + E   +P +V  L+   V QI CG NH+LA + S G +Y++G   +GQLG+    ++ H   P+ 
Sbjct:    1 MASGKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR---PLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLA-LTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLR 191          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Match: Herc4 (gene:FBgn0035207 transcript:FBtr0310555)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 364/1070 (34.02%), Postives = 580/1070 (54.21%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQ-----IQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGR--DKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVST--PQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKH-----PTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNR--NYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYF----KKFCMVFINAINNEINGFEGQNTKKKFSDII----EMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLP--CFMAQSSFH----------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            ++ +G+ S+GQLG+     +    P +I     + +++++CG  HTLFL   GK+Y+CG+N++ +LGHD    +P       I  L  + +I    G  H+  +++ G V +WG N  G+LG   DK      K+V+ L    +VQ+ACG++H+LALT   E++SWG+N  GQLG+    D+     P ++  L  +P+ +I  G   SF+++ SG ++ WG NN GQLG +  T+  S P  +K LR   + +V+ G      L+ +GGVFT G G YGQLGH    N+ +P +VM+L+GS ++Q+ CG  HTLA + S G VYAFGLG  GQLG   T  +    + + G WV     + S +     ++   ++++++ GG+ SI+T +      KV P+D R +N K         +T       + + + +  + SI  +  S      S  LD  +  F  S  NHGL++           + ++    Q +     DNI  ++  +   +   +E +R +L+  +      S+  K + +PF+ +   + E P   LNKW+      YF    + F  V I+ I+ ++       + ++   ++    E++ +   +  L QIN + +  ++Y  FY P +    D++  Y  W+   +  +F++ +Y F+FD   KT L++ +    M   +     MA S F+          + V R+NL+ D++ +L   +Q  LKK  ++ F GE+A D GGV KE F+L++  +L+P YG+F+ Y +SRL WF  + F+     F  IG L GLAIYN  +I+L FPL +FKKLL +  +L DL +L+P    S+Q LLDY  +DF+++F L F +S + +G      L  +G +  VTL NRQ +VDLYVD++ NK+VE  +  F +GF     G+ +  F+P EL  ++VG+E YDW  L+ +CEY   Y +    I WFW     +S  EKK FL +LTG DR+PI GM  +K+ IQP   D+ +LPVAHTC+NLLDLP+Y ++  L+ KL  AI+  +GF+LV
Sbjct:    7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETN-RSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLM-LPQVVIGPWV---SPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFV--DKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLD-HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIW----DNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1062          

HSP 2 Score: 122.094 bits (305), Expect = 1.186e-27
Identity = 69/197 (35.03%), Postives = 106/197 (53.81%), Query Frame = 2
Query:  551 LTKNSEIFSWGANTCGQLGLGDNFD-MVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLP--LMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGH-NNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPIN 1129
            +    E++ WG+ + GQLGLG   D  + TP QI    +  ++ +  G + +  LT +G +Y+ GSN+Y QLG DL T    +   L++  L+   I+ +  G  H  ALS  G V +WG    GQLGH  + E   +P +V  L+   V QI CG NH+LA + S G +Y++G   +GQLG+    ++ H   P+ 
Sbjct:    1 MASGKELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLA-LTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLR 196          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Match: Ube3a (gene:FBgn0061469 transcript:FBtr0076186)

HSP 1 Score: 228.024 bits (580), Expect = 4.065e-61
Identity = 133/353 (37.68%), Postives = 209/353 (59.21%), Query Frame = 2
Query: 2162 ITVRRDNLLGDTISQLHRATQCH---LKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSL-ECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKF-FKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +TVRRD L+ D +  L      +   LKK   V F+GE  +DEGGV KE F L+V ++ NP +G+F    E+   WFN   F+ N  QF  IG + GLAIYNNV + ++FP+V+++KL+       DL + +P L KSL+ +LDY   D E++F   F +S  + +G+ +++EL+ +G D  V   N++ +V+LY D++LN N+EQ F  F++GF        LK  F+P E++ L+ GS  +D++ L  S  Y G Y    Q I  FW+   ++  ++K K L + TG  RVP+ G+  +++ I     D + LP +HTC+N+L LP+Y+S   L ++L  AI  ++GF ++
Sbjct:  622 LTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFE-NGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGML 973          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Match: HERC2 (gene:FBgn0031107 transcript:FBtr0301344)

HSP 1 Score: 166.007 bits (419), Expect = 7.658e-41
Identity = 98/273 (35.90%), Postives = 152/273 (55.68%), Query Frame = 2
Query:  227 GFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKV--KPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGR-DKLSDFSIKLVQSLTGHFIVQVACGHD--HTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGH-NNFENKSIPCIVMDLLGSKVSQIECGMNHTLAY 1027
            G  H L L  +GK++S G  E  KLGH       KP  ++ L A K+ D + G  H+A +++ G ++TWG   +G LG  D  +    KLV +L G  +VQVACG     TLALT++  +FSWG    G+LG G + +   TP +I+ LS + +  I  G +FS  LT +G +++WG  +Y +LG      +   P  +  LR + +++V+VG  H  A++  G V+ WG   +GQ G  N F NK  P +V+ L    V+++ CG +H++A+
Sbjct: 3081 GGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGS-EGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHG-GDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKK-PALVIGLDAVFVNRVACGSSHSIAW 3350          

HSP 2 Score: 156.377 bits (394), Expect = 7.010e-38
Identity = 93/276 (33.70%), Postives = 142/276 (51.45%), Query Frame = 2
Query:  227 GFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKV---KPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGR-DKLSDFSIKLVQSLTGHFIVQVACGHD--HTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVS 1036
            G  H L L   G++Y+ G  E  KLGH  N++   +P  ++ L+   + D + G  H+A +T  G V TWGK  +G LG  D       KLV++L G+  + +ACG     TL +T +  ++SWG    G+LG G + D    P +I++L+ L +  +  G +FS  LT SG +Y+WG  ++ +LG   +  +   P  V  L+ + I+ ++ G  H  A S  G V+TWG    GQLG         P +V  L G  + ++ CG  HTLA   S
Sbjct: 4144 GGKHCLALTTEGEVYAWGEGEDGKLGHG-NRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGS-DGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHG-SVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTS 4416          

HSP 3 Score: 135.961 bits (341), Expect = 1.302e-31
Identity = 92/298 (30.87%), Postives = 151/298 (50.67%), Query Frame = 2
Query:  227 GFDHTLFLL-KNGKLYSCGNNEFKKLGHDC--NKVKPNQIQMLDAH--KLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI-KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAG--DKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDT 1096
            G   +LF++ ++GK+Y+CG     +LG     N   P+Q+ +L  +  K +   +G  H   +T  G VF+WG+   G+LG    +     +LV++L    I  VACG  H+ A++   E+++WG    G+LG GDN   +  P+ +  L+   +  +  G  D  +  LT  G ++SWG  ++G+LGR  +   ++ P  ++ L    +V +  G     AL+  G V+TWG G Y +LGH   ++   P  +  L G +V  +  G  H LA +   G VYA+G    GQ G  +T
Sbjct: 3026 GGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLK-PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDT-PHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLA-VTDAGQVYAWGDNDHGQQGSGNT 3320          

HSP 4 Score: 118.627 bits (296), Expect = 2.587e-26
Identity = 75/228 (32.89%), Postives = 121/228 (53.07%), Query Frame = 2
Query:  416 VFTWGKNSFGELGRDKLSDFSI-KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSIT--AGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMN--HTLAYMVSTGTVYAFGLGKFGQLG 1084
            V  WG N   +LG  K S   +    Q+++    + +A G      ++++ ++++ G  T G+LGLG   + V  P Q+  L    +K +   +G K +  LT  G ++SWG    G+LG    T+ +  P +V+ LR + I  V+ G +H AA+S  G ++TWG G YG+LGH +   +  P +V  L G +V Q+ CG     TLA +   G V+++G G FG+LG
Sbjct: 2988 VMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHN-VPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK-PRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLA-LTEDGAVFSWGDGDFGKLG 3212          

HSP 5 Score: 111.309 bits (277), Expect = 4.297e-24
Identity = 87/282 (30.85%), Postives = 134/282 (47.52%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVK--PNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI-KLVQSLTGHFIVQVACGHD--HTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDL---TTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSI--PCIVMDLLGSKVSQIECGMNHTLAYMVST 1039
            C   H L +  N   YS G  E  +LGH     +  P +I  L+ H +     G  ++A +T  G + TWG+ ++  LG     D S+  LV +L+ H +V VA G    H+LALT    +F+WG    G+LG G N +    P  +++L    ++ + AG +FS  L+  G LY+WG      LG  L   +    S+P +V  L+ + IV V+V   H  ALS  G VF WG     Q+   +  ++ +    I++ L     S I C    +L +  S+
Sbjct:  623 CEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNG-NCNGSLQPILVESLPR--VQRVFAGSQFSVALSSEGQLYTWGKATC--LGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWTQSS 899          

HSP 6 Score: 106.301 bits (264), Expect = 1.218e-22
Identity = 80/262 (30.53%), Postives = 138/262 (52.67%), Query Frame = 2
Query:  416 VFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIK--SITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVS-TGTVYAFGLGKFGQLGI--CDTVEICHTAKPING-HWVPLECNNQSKIS 1174
            ++ WG N  G+LG   L    IK     ++L+    VQ+A G     A+T + ++F+ G  + G+LG+G + D  + P  + +L ++ +K  ++ +G K    LT  G +Y+WG    G+LG     SY+  P +V+HL    +  ++ G  H AA++  G V TWG GRYG+LGH + E++  P +V  LLG +   I CG        ++    V+++G G +G+LG    D  ++ +  + + G   V +EC +Q  ++
Sbjct: 4051 IYGWGHNHRGQLG--GLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGS-DSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDR-PKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVA 4308          

HSP 7 Score: 90.8929 bits (224), Expect = 6.517e-18
Identity = 64/189 (33.86%), Postives = 101/189 (53.44%), Query Frame = 2
Query:  536 DHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPI--VYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDT 1096
            D  L+    S I+ WG N  GQLG G     + TP   + LS L    +  G++  F +TP G L++ G  + G+LG   + S+ ++P ++  L+   +  V V+ G  H  AL+ +G V+ WG G  G+LGH N  +   P +V  L G  V+ I CG  H+ A + ++G V  +G G++G+LG  D+
Sbjct: 4040 DWALSWGGASTIYGWGHNHRGQLG-GLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSW-AIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAA-ITASGHVLTWGKGRYGRLGHGDS 4225          

HSP 8 Score: 88.5817 bits (218), Expect = 3.376e-17
Identity = 61/191 (31.94%), Postives = 92/191 (48.17%), Query Frame = 2
Query:  494 SLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQN--HVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFG 1060
            S+ GH      C   H LA+  N   +SWG     +LG GD     + P +I  L    ++S+  G  +S  +T  G L +WG   Y +LG    +   SLP +V  L    +V V++G    H  AL+ +G VF WG G YG+LG+ N      P +V  L   +V ++  G   ++A + S G +Y +G
Sbjct:  618 SIAGH------CEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHAR-AVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHG-NSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESL--PRVQRVFAGSQFSVA-LSSEGQLYTWG 797          

HSP 9 Score: 76.2554 bits (186), Expect = 1.818e-13
Identity = 58/205 (28.29%), Postives = 102/205 (49.76%), Query Frame = 2
Query:  488 VQSLTGHF-IVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITA---GDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMN--HTLAYMVSTGTVYAFGLGKFGQLG 1084
            V +L+  F I QVAC     L L++  ++++W      +L   +     + P  ++ +++    SI     G  F   +  +   YSWG+    +LG    T   ++P  +  L +  +  V  G ++ AA++  G + TWG G Y +LGH N +++S+P +V+ L    V  +  G    H+LA + S G V+A+G G +G+LG
Sbjct:  565 VPTLSCRFQIKQVACCETQMLILSQEGKLYTW------RLAKPE-----AEPLPMEEVAHDVFISIAGHCEGRHF-LAIDSNHNAYSWGTGEDHRLGHG-DTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLA-LTSEGLVFAWGDGDYGKLG 755          

HSP 10 Score: 67.3958 bits (163), Expect = 8.678e-11
Identity = 89/354 (25.14%), Postives = 159/354 (44.92%), Query Frame = 2
Query: 2180 NLLGDTISQLHRATQCHL---KKSFRVNFMGEDALDEGG--------VMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDD--NLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFM---LNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIK-----IKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAI 3178
            ++ G  + +L   TQ  L    + ++V F+GE   D GG        +  EL    VP ++N   G  E    +R C+           +  F  +G L G+A+     + ++    ++++L  E     DL E++      L  + + D  D   +F    L F  S    G+++     R  +  P    NR  YV L + + L++  EQ  K  ++G    +    L  F   ELQ ++ GS      LL+    Y G +  +  ++ WFW      +  E+  FLR++ G  R+P   ++D +     +++   N  D++LP ++TC+ LL +P+Y+ +++L +KLK AI
Sbjct: 4531 SVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEA-GANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMD--DDPKLFTALELPFSTS-SARGHEVPLS-TRYTHISP---RNRAEYVRLALGFRLHEFDEQ-VKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873          

HSP 11 Score: 56.6102 bits (135), Expect = 1.774e-7
Identity = 59/216 (27.31%), Postives = 105/216 (48.61%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFD--HTLFLLKNGKLYSCGNNEFKKLGH-DCN-KVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNS-FG-ELGRDKLSDFSI-KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLG--DNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPS 721
            ++ ++G  +Y +LG    N D  S P  +  +S   +  ++ G    H+L L   G +++ G+ ++ KLG+ +CN  ++P  ++ L   ++    AG   +  +++ G ++TWGK +  G +L    +   S+ +LV SL    IV VA    H LAL+ + E+F WG N   Q+      +  ++ TP  + +L   P   I      S V T S
Sbjct:  688 NLLTWGRGTYARLG--HGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLP--RVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILV-SLPTFPASGIACTSAQSLVWTQS 898          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:ZFIN;Acc:ZDB-GENE-070801-1])

HSP 1 Score: 634.41 bits (1635), Expect = 0.000e+0
Identity = 387/1082 (35.77%), Postives = 589/1082 (54.44%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDF--SIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICH--TAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIIT-ASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCK--------LHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-----VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL----------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G AS+GQLG+   +++    P++ +      +  + CG  HT+FLL++G +Y+CG N+  +LGH+  + KP Q+  LDA  ++  S G  H   + + G VF WG  S G+LG   + D     + V+SL+   I QVACG+ H+LAL +  EIFSWG N  GQLGLG     V +PQ I++L  +P   I+AG   SF LT SG ++ WG N +GQLG          P+++K LR Q +VY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS VSQI CG  HTLA++ S+G + +FGLG  GQLG   T   C+  +  P+ G W     +        + AE+ Y VKR+Y GG+ S    A S D G    P D+R+   +    I  ++ ++ +        +  I   +   +  + SS   +  S    S  +H        G++I+    +  +   +      Q +A  ++ N+  ++  + + P +E LR +L      +L        + IPF+ +   + + P   L  W    +P  F++   ++   +   +         +K    +  + +F C           LH +NE   +II Y+ FYI ++ ++ D+   Y  W +      V   + +L  YPF+FD   KT L++ +A   M   +                      PC +      + VRR+N++GD++  L ++     KK  +V F+GE+A+D GGV KE FLL++ ++L+P YG+F  + ESRL WF    F+D +  F+ IG + GLAIYN  +++L+FPL ++KKLL +   L+DL EL P +G+SLQ LLDY ++D E+ F LNF ++ + +G     ELI +G D  V  SNRQ +V+ YVDYI NK+V   F  F  GFH    GK L+ F+P ELQ +++G+ +YDW  L KS EY GEYW +H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  + + IQP    + Y PVAHTC+NLLDLPKYTS++ +++KL  AIE+N+GF LV
Sbjct:    1 MLCWGNASFGQLGLGGIDEEVLLEPRRCEFFEGKRVRDVGCGRRHTVFLLEDGTVYTCGCNDLGQLGHEKARKKPEQVVSLDAQNIVAVSCGEAHTLALNDKGQVFAWGLGSDGQLGLSIVEDCLRVPRTVKSLSEVHITQVACGYWHSLALARGGEIFSWGQNKYGQLGLGQQGACVCSPQVIQSLQGIPFGQISAGGAHSFGLTLSGAIFGWGRNKFGQLGLG-DNDDRRFPVLLKTLRSQQVVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSVVSQIACGRQHTLAFIPSSGKIDSFGLGGNGQLG---TRSTCNRISPTPVKGCW---RAHADPVAMDHSEAERSYCVKRIYAGGDQSFAHYALSEDDGP---PLDVRIT--RPAGQIYTLSTELIQKWLNH--GLGRIPAEITDEIDLVFSSASCLNGSFLSSSNPDHYSTSSKCSGVDINTARLLFHKLIQTDHPQISQIIAASLEKNLLPKL--SSSPPDIEALRLYLTLPECPLLCNPNNFTTLTIPFAKAIVSLKDAPIKVLGNWWSRFEPVVFQRLVELYKEVVVYLLR-------MQKLGIPLSEQRIFTCFLDTSLKLLEILHSVNERAGQIIQYDKFYIHELDELIDIRNDYATWFQQQMFSVVMDSQVTLCKYPFVFDAQAKTALLQTDAVIQMQMAVDQAQRQNFTSLFLSGGGVESVNPCLI------LIVRRENVVGDSMEVLRKSKNVDYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLHPKYGMFRFHEESRLIWFACKTFED-IDLFHLIGVVCGLAIYNLTIVELNFPLALYKKLLKKTPTLEDLKELMPDVGRSLQQLLDYTEDDLEETFCLNFTITEDNFGATEVVELIPNGTDISVNKSNRQEFVNAYVDYIFNKSVAPQFSAFYAGFHKVCGGKVLELFQPSELQAMVIGNTNYDWKELEKSTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLALVIQPTAGGEQYFPVAHTCFNLLDLPKYTSKNTMQEKLLHAIEHNQGFNLV 1052          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:ZFIN;Acc:ZDB-GENE-090313-139])

HSP 1 Score: 566.229 bits (1458), Expect = 0.000e+0
Identity = 364/1082 (33.64%), Postives = 578/1082 (53.42%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSII---TASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHG--------LNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQI--QYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVF---------DCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF---------SLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G++  GQLGI       +  P+         +++++CG  H+LFLL +G +Y+CG+N   +LGHD    +P  +  LDA K+   S G  H+  V   G VF WG    G+LG     +     +L++ L  H I QV CG+ H +AL+K+ ++F WG N+ GQLGLG       +PQ +K+L  +P+  I+AG   SF L+ SG ++ WG N+ GQLG +      ++P  +K LR Q +VY+S G+ H AAL+ +GG+FT+G+G  GQLGH++  N+ +P  VM+L+G++VSQI CG NHTLA++ STG +YAFG    GQLG      I  +AK      VP+       I    T  +   + +++ GG+H+ +   T   L C     PDD R+ N     +I ++N   +E + +    +   S+   ++   L  S     N+ F + Q++ G          ID  FN +   F +        L  ++  +  S +  Q   + P +E +R +LI +     + S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G +             + PVF           L KLH++N   +R+  YN FYIP I  + D++  Y  W    + I+          +L  YPF+ +   KT +++ +A+  M                 +   +A++ F +  VRR++L+ D + +L       LKK  +V F GE+A+D GGV KE FLL++ +++NP YG+F  Y ES L WF+   F ++   F+ IG + GLAIYN+ ++DLHFPLV++KKLL     LDDL EL+PT G+SLQ LL+++  D E+ F LNF ++ E YG     EL++ G    V  +NR+ +V  Y+ Y+ +  V++ +  F  GF     G+ L  F+P EL  ++VG+ +Y+W  + K+  Y GE+   H  +  FW  F   S ++KK+FL +LTG DR+PI+GM+ ++I IQ    +++YLPVAHTCYN+LD+P Y ++  LR +L  A+E  EGF+LV
Sbjct:    2 MLCWGSSGAGQLGIGASEASVFE-PRSCCVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQLGHDKGGSRPELVGALDAQKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAEEAVRVPRLIKKLCEHRISQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEPSTLSPQPLKSLCGIPLTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLN-DEQDRAVPCHIKFLRSQKVVYISCGEEHTAALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELMGTEVSQIACGRNHTLAFVPSTGLIYAFGCNTQGQLG----TGIRGSAKSP----VPVSNIQPLCIGNAYTRTEHCTIAKIHSGGDHNFLLLSTVEGLSC-----PDDFRILNTTK--SIALIN---SESLDSWRMKLHDNSDSSITNDIILLLSSTACWNASF-LDQSDDGHFKTNPKVPGID--FNAVRLLFETLMKPAFARLLEQITKSFESLLIPQLPCSPPDVEAMRIYLILSECPAFQDSKNYITLTIPLAMAILRLDANPSKVLDNWWSLMDCTVFTRLVEMYKSIVVFLLTGGKAL-----------LMPVFLESYTSAALRLLEKLHKVNLKAHRV-EYNHFYIPDIATLVDIQEDYLKWFLRKADIKMRYPPVQGSVTLCAYPFILNAQAKTTVLQTDAELQMQMAVSGANLHNVFMLLTMEPLLARNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEH-NWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEFE-GDVEETFCLNFAITREYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASLRIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSLV 1046          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Match: si:ch73-190m4.1 (si:ch73-190m4.1 [Source:ZFIN;Acc:ZDB-GENE-090311-56])

HSP 1 Score: 371.703 bits (953), Expect = 3.646e-111
Identity = 279/927 (30.10%), Postives = 462/927 (49.84%), Query Frame = 2
Query:  488 VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIK---NSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFA--VSTI-----LEISEFCKVILIPFS-VSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN----------VSKIEFSLFDYPFLFDGITK-TNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMK-ELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPV-NVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGF 3196
            ++ L    ++Q+ACG  H++ALT + ++F WG N  GQLGL        +P+ +++L  +P+  I+AG   SFVL+ SG ++ WG N+ GQLG   TT    +P +V  L+++ IV +S G  H AAL+  G VFT+G G +GQLGHN+F+++  P +V +L GSKVSQ+ CG NHTL    S   +Y+FG G  GQLG  + V+            VPL  +  ++ + E      Y +++L  G NHS       + G +  PD  R         I   +  + E         K+I ++     +  S +   +K   +  +  S+   GL+  L  + ++    S++   + T+   +++++   +  N N    E LR +++    +S +      E++E     ++  S  +  ++    S   + W+ NL  + FKK    F   I  E      +    KF +I++         +++Q+    NR I    F I ++  + D+  +    + N          +  +E     Y   F  +T    +  +EAKC         + +  F +TVRR  LL D +  L+  TQ HL+  +      E+      V K + FL V  ++ +P   LF       + WF   +  +    F   G L GLA  N+ +++L FPL +FKKLLN K +L+D IE NP  G+SLQ +L+Y  +  E+  +      L    +  E +L     ++ +T SNR  +VD YVD+I N++V++ F+ F+ GF    + + ++ F+P EL+ ++VG+E YDW +L+++  Y G +  +H +I  FW  F  L+ +EKK FL +LTG +RVPI GMS +K+++  + N  +++LP   TC++LL LPKY     LR K+  AI +  GF
Sbjct:  112 LKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPRHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTD-RFVPTVVNSLKRKKIVSISCGGEHTAALAKGGTVFTFGSGGFGQLGHNSFKDEHHPRLVAELWGSKVSQVTCGRNHTLVSTASPKLIYSFGCGMQGQLGNGEQVK----------QSVPLPVDQPTEYNDE------YTIQKLVAGENHSFALYFK-ELGNEANPDPTR--------GIMTFDNGMIEQCECGKDPRKAIKDLKKVFSSAASLNGSFLKTRHDGHYQTSEEYCGLDFGLVESSIATL--SRNERLISTVLKVLQESLLPTL--NPNPTGEESLRLYILLPELISHLKSEQKAELTEALASKILNLSPAALRVLEIYWSKLPDDWLKNL-VKLFKKASAKFFGRIIVENVNNVAKTHMLKFVEILQ---------RVYQVCCSANRNIKKRYFIIHEVNNLLDVLQTMNADVNNNWPWFNLTGQIHALEAQRNAYEETFRKLTSFPCIFNLEAKCSYMRNR---VWKGRFELTVRRTALLEDCLCLLNPGTQQHLRDKWLSILFTENVSKRTDVHKRDFFLNVFKELCDPASQLFMYNDNETMIWFPAKLTVEKKKYF-LFGILCGLAFNNSSVVNLPFPLALFKKLLNIKPSLEDFIEFNPVHGRSLQYILEYSNDVLEESSL-----PLTIIWSGSELDLDPAEPEQHITTSNRTKFVDEYVDHIFNQSVKEAFEEFRRGFFRGCEKRLVEMFEPEELRGVLVGNEEYDWNILKQNTTYEGVFNADHPVIISFWEVFDDLTPNEKKSFLLFLTGFERVPILGMSAVKMRVTHLANSTEDHLPETLTCHSLLQLPKYEKRETLRAKVIEAISHKRGF 989          

HSP 2 Score: 118.627 bits (296), Expect = 1.923e-26
Identity = 66/213 (30.99%), Postives = 118/213 (55.40%), Query Frame = 2
Query:  335 IQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG--RDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNH-VAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIV 964
            ++ L+  ++I  + G  H+  +TN G +F WG+N+ G+LG  +++    S + +QSL G  + Q++ G +H+  L+ +  +F WG N+ GQLGLGD  D    P  + +L    I SI+ G + +  L   G ++++GS  +GQLG + +   E  P +V  L    +  V+ G+NH + + +    ++++G G  GQLG+     +S+P  V
Sbjct:  112 LKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPRHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTDRF-VPTVVNSLKRKKIVSISCGGEHTAALAKGGTVFTFGSGGFGQLGHN-SFKDEHHPRLVAELWGSKVSQVTCGRNHTLVSTASPKLIYSFGCGMQGQLGNGEQVKQSVPLPV 322          

HSP 3 Score: 104.375 bits (259), Expect = 4.803e-22
Identity = 75/229 (32.75%), Postives = 111/229 (48.47%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLG---HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPS-GFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVY--------VSVGQNHVAAL 871
            CG  H++ L  +G+L+  G N   +LG          P  +Q L    +   SAG +H+ V++  G+VF WG NS G+LG    +D F   +V SL    IV ++CG +HT AL K   +F++G+   GQLG  ++F     P+ +  L    +  +T G   + V T S   +YS+G    GQLG       +S+PL V     QP  Y        +  G+NH  AL
Sbjct:  125 CGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPRHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTDRFVPTVVNSLKRKKIVSISCGGEHTAALAKGGTVFTFGSGGFGQLG-HNSFKDEHHPRLVAELWGSKVSQVTCGRNHTLVSTASPKLIYSFGCGMQGQLGNGEQVK-QSVPLPV----DQPTEYNDEYTIQKLVAGENHSFAL 347          

HSP 4 Score: 85.5001 bits (210), Expect = 2.574e-16
Identity = 64/210 (30.48%), Postives = 101/210 (48.10%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNSE-IFSWGANTCGQLGLGDNFDM-VSTP--QQIKNLSNLPIKSITAGDKFSFVL 712
            +F +G  + GQLG+        S P+ +  +    + +IS G +H+  L  +G ++  G N   +LG     ++  P  +  L   K++  S G +H A +   G VFT+G   FG+LG +   D    +LV  L G  + QV CG +HTL  T + + I+S+G    GQLG G+     V  P  Q  +      I+ + AG+  SF L
Sbjct:  139 LFVWGENALGQLGLRKEQAGTQS-PRHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTDRFVPTVVNSLKRKKIVSISCGGEHTAALAKGGTVFTFGSGGFGQLGHNSFKDEHHPRLVAELWGSKVSQVTCGRNHTLVSTASPKLIYSFGCGMQGQLGNGEQVKQSVPLPVDQPTEYNDEYTIQKLVAGENHSFAL 347          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Match: slc47a2.2 (solute carrier family 47 member 2.2 [Source:ZFIN;Acc:ZDB-GENE-070615-14])

HSP 1 Score: 343.969 bits (881), Expect = 5.881e-101
Identity = 295/940 (31.38%), Postives = 458/940 (48.72%), Query Frame = 2
Query:  488 VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNN---QSKISGETTAEQMYI------VKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQS--SDYLQ-TLAVRMKDNIFSQ------IQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIP---KVFDLEYSYELW----------LRNVSKIEFSLFD-------YPFLFDGITKTNL-MKIEAKCLMS--EGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNV--DDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAI 3178
            ++ L    ++Q+ACG  H++ALT + ++F WG N  GQLGL        +PQ +++L  +P+  I+AG   SFVL+ SG ++ WGSN+ GQLG   TT    +P +VK L  +  V +S G  H A LS  G VFT+G G +GQLGHN+ +++  P +V +L GSKVSQ+ CG +HTL +  S+  +Y+FG G  GQLG  + V+      P+    +P EC     +  I+GE  +  ++        ++   G N  I+T +     + V   D     W  PT        +   I T  S+  S++     +           ++  +  S    GL+ DL     ++  +S+S  S+ +Q TL   +  N   +      +        L+  R  LI A++   +I E C        + +S +        + W   L  + F K     I  I+      +     K F +I++M   +   C  +  N D         F IP++    +  D   +  LW          L N  K+E   F        +PF+ D +TK ++ + ++ +C+ S  + L   +  +  HI   R+++L DT+  L   T   +    +V F+GED +DE  +  E F L+    +  D  + E++ ES L WFN     D+   F  +G + G+A+YN   I++ FPL +FKKLL +K +LDDL EL+P   +SL+ LL+ D+ +  D+  L+F     C G     EL+ +G    V   NRQ YVDLYVD++ NK+V+  F+ F EGF           F P ELQEL+ GS  Y+W  L++S  Y G   ++ ++I  FW  F  LS + KKKFL +L G +RVP  G S   +KI   +    D++LP A TC+  L LPKY+  + LRDKL  A+
Sbjct:  110 LKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTD-RFIPTIVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQVTCGRHHTLVFEDSSNQIYSFGCGMQGQLGNGEQVKQS-VPLPV---LLPTECTEFTMEKLIAGENHSFALFFKSPGNESEKPKSGSNGGILTLNDRIIDRWVSESD----PW--PT--------IKNEINTVFSSAASLNGSFLKTS----------RDEHYQTSVERCGLDFDLVKTSFAKLSTSKSLISEVVQQTLLPSLNPNPTGEEALRLYLLLPELINGLKKQRTKLIEALA--FKILELCPAARKVLEMYWSRLP-------DDWFEALI-KLFHKESAELIKQISRGETDDQSTRHLKNFLEILQM--AYQICCSTNITNHD---------FIIPEVNDLLETLDATSAEVLWMASRLPINEELHNRMKLEDYYFKTAEILVKFPFVSDFLTKKSMFILLQEQCIRSLLDLLVVHLNGNLLHIN--RESVLTDTLQYLRPFTYSFMH-PLQVAFIGEDEIDEKVISAEFFSLISKSFIEWDKKILEVH-ESSLVWFNPHHTQDHR-DFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLEEDEEEVVDLQHLDFT----CKGQ----ELVPNGSQIQVNKVNRQKYVDLYVDFVFNKSVKTQFEQFTEGFSEGCPLDAWTMFHPEELQELLHGSPQYNWNELQQSASYEGCSASD-ELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGGFSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLRDKLIHAV 985          

HSP 2 Score: 120.168 bits (300), Expect = 6.558e-27
Identity = 70/236 (29.66%), Postives = 128/236 (54.24%), Query Frame = 2
Query:  335 IQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG--RDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGG-VFTWGHGRYGQLGHNNFENKSIPCIVM---DLLGSKVSQIECGMNHTLA 1024
            ++ L+  ++I  + G  H+  +TN G +F WG+N+ G+LG  +++    S + +QSL G  + Q++ G +H+  L+ +  +F WG+N+ GQLGLGD  D    P  +K+LS     SI+ G + +  L+  G ++++GS  +GQLG + +   E  P +V  L    +  V+ G++H          ++++G G  GQLG+     +S+P  V+   +     + ++  G NH+ A
Sbjct:  110 LKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRF-IPTIVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHN-SLKDEHHPRLVAELWGSKVSQVTCGRHHTLVFEDSSNQIYSFGCGMQGQLGNGEQVKQSVPLPVLLPTECTEFTMEKLIAGENHSFA 343          

HSP 3 Score: 111.309 bits (277), Expect = 2.793e-24
Identity = 66/172 (38.37%), Postives = 85/172 (49.42%), Query Frame = 2
Query:  593 CGQLG---LGDN-----FDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLG 1084
            CG+ G   L D+      D  +  + +K L N  +  I  GD+ S  LT  G L+ WG N  GQLG     +    P  ++ L   P+  +S G NH   LS+ G VF WG    GQLG  +  ++ IP IV  L G K   I CG  HT A +   GTV+ FG G FGQLG
Sbjct:   84 CGEAGAVLLADDGKVLVMDQSTVCRPLKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVSISCGGEHT-ATLSKGGTVFTFGSGGFGQLG 254          

HSP 4 Score: 98.2117 bits (243), Expect = 3.117e-20
Identity = 69/224 (30.80%), Postives = 110/224 (49.11%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLG---HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLT-PSGFLYSWGSNNYGQLGRDLTTSYESLPLMV---KHLRKQPIVYVSVGQNHVAAL 871
            CG  H++ L  +G+L+  G N   +LG          P  +Q L    +   SAG +H+ V++  G+VF WG NS G+LG    +D F   +V+SL+G   V ++CG +HT  L+K   +F++G+   GQLG  ++      P+ +  L    +  +T G   + V    S  +YS+G    GQLG       +S+PL V       +  +  +  G+NH  AL
Sbjct:  123 CGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLG-HNSLKDEHHPRLVAELWGSKVSQVTCGRHHTLVFEDSSNQIYSFGCGMQGQLGNGEQVK-QSVPLPVLLPTECTEFTMEKLIAGENHSFAL 344          

HSP 5 Score: 88.5817 bits (218), Expect = 3.229e-17
Identity = 64/210 (30.48%), Postives = 103/210 (49.05%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDNFDMVSTPQQI---KNLSNLPIKSITAGDKFSFVL 712
            +F +G  + GQLG+        S PQ +  +    + +IS G +H+  L  +G ++  G+N   +LG     ++  P  ++ L   K +  S G +H A ++  G VFT+G   FG+LG + L D    +LV  L G  + QV CG  HTL    +S +I+S+G    GQLG G+     S P  +      +   ++ + AG+  SF L
Sbjct:  137 LFVWGENALGQLGLRKEQAGTQS-PQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQVTCGRHHTLVFEDSSNQIYSFGCGMQGQLGNGEQVKQ-SVPLPVLLPTECTEFTMEKLIAGENHSFAL 344          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Match: si:ch211-281g13.5 (si:ch211-281g13.5 [Source:ZFIN;Acc:ZDB-GENE-090311-7])

HSP 1 Score: 337.806 bits (865), Expect = 8.664e-99
Identity = 297/936 (31.73%), Postives = 462/936 (49.36%), Query Frame = 2
Query:  488 VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNN---QSKISGETTAEQMYI------VKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQS--SDYLQ-TLAVRMKDN------IFSQIQYNRNYPSLECLRFFLIFAV-STILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTK--KKFSDIIEMKPVFDCLCKL-------HQINE--DHNRIIHYN----TFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKI-EAKCLMSEGLPCFMAQSSFH--ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNV--DDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAI 3178
            ++SL    ++Q+ACG  H++AL+ + ++F WG NT GQLGL        +PQ +++L  +P+  I+AG   SFVL+ SG ++ WGSN+ GQLG    T    +P +VK L  +  V +S G  H A LS  G VFT+G G +GQLGHN+ +++  P ++ +L GSKVSQ+ CG +HTL +  S+  +Y+FG G  GQLG  + V+      P+    +P EC     +  I+GE  +  ++        ++   G N  I+T +     + V   D     W  PT        V   I T  S+  S++     +           ++  +  S  + GL+ DL     ++ F+S+S  S+ +Q TL   +  N      +   +        L+  R  LI A+ S ILE++   + +L  +               + W   L  + F K     I+ I +E +    Q+T+  K   +I++M     C   +       H+IN+  D  + I  +      Y+       D+    E + R V KI   L  +PF  D ITK  +  + + +C  +  +P     +SF   + + R+++L DT+  L + T   +    +V F+GED +D  G+  E F L+    +  D  + E++ ES L WFN      N   F  +G + G+A+YN   I++ FPL +FKKLL +K +LDDL EL+P   +SL+ LL+ D+ +  ++  L+F     C G     EL+ +G    V   NRQ YVDLYVD   NK+V+  F+ F  GF           F P ELQEL+ GS  Y+W  L++S  Y G   ++ ++I  FW  F  LS + KKKFL +L G +RVP  G+S   +KI   +    D++LP A TC+  L LPKY+  + L DKL  AI
Sbjct:  109 LKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLG-DTKDRFVPTIVKSLCGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQS-VPLPV---LLPTECTEFTMEKLITGEHHSFALFFKNPGNESEKPKSGSNGGILTLNDRMIDRWVSESD----PW--PT--------VKNEINTVFSSAASLNGSFLKTS----------RDEHYQTSVEHCGLDFDLVKTSFAKLFASKSLISEVVQQTLLPSLNPNPTGVEALRLYLLLPELINGLKKQRTKLIEALASKILELNSAARKVLEMYWSRLP----------DDWFERL-IKLFHKESTDLIDQICDETDH---QSTRHLKNILEILQMAYQISCSTDITHHDFIIHKINDLLDLLQTITADLLRMELYMQINEDFHDMVKLEEYYFRTV-KI---LVKFPFASDFITKQRMFNLLQEECFRN--VPNLAMGNSFSNLLHINRESVLTDTLQYLRQNTHSFMH-PLQVAFIGEDGIDMRGLSAEFFSLISKSFIEWDKKILEVH-ESSLVWFNPHHTRGN-KNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLEEDEEEVVNLQHLDFT----CKGQ----ELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASYEGCSASD-ELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGGLSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLHDKLIHAI 983          

HSP 2 Score: 114.005 bits (284), Expect = 4.835e-25
Identity = 80/256 (31.25%), Postives = 122/256 (47.66%), Query Frame = 2
Query:  320 VKPNQIQMLD-AHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLG 1084
            VKP Q++  +   K   +SA  D +A  + +G +   GK S   L  ++ +D  ++ +Q L    I  + CG    + L  + ++                 D  +  + +K+L N  +  I  GD+ S  L+  G L+ WG N +GQLG     +    P  ++ L + P+  +S G NH   LS+ G VF WG    GQLG  + +++ +P IV  L G K   I CG  HT A +   GTV+ FG G FGQLG
Sbjct:   16 VKPEQVRHGNWGIKFCPSSAVQDISAGKSCIGFIRE-GKVSVLRL-HNEDADEKLEPLQ-LQNERIRSIVCGEAGAVLLADDGKVLI--------------MDQSTVCRPLKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHT-ATLSKGGTVFTFGSGGFGQLG 253          

HSP 3 Score: 111.309 bits (277), Expect = 3.116e-24
Identity = 62/214 (28.97%), Postives = 117/214 (54.67%), Query Frame = 2
Query:  335 IQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG--RDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGG-VFTWGHGRYGQLGHNNFENKSIPCIVM 967
            ++ L+  ++I  + G  H+  ++N G +F WG+N+ G+LG  +++    S + +QSL    + Q++ G +H+  L+ +  +F WG+N+ GQLGLGD  D    P  +K+L      SI+ G + +  L+  G ++++GS  +GQLG + +   E  P ++  L    +  V+ G++H          ++++G G  GQLG+     +S+P  V+
Sbjct:  109 LKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRF-VPTIVKSLCGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHN-SLKDEHHPRLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQSVPLPVL 320          

HSP 4 Score: 96.6709 bits (239), Expect = 8.730e-20
Identity = 65/200 (32.50%), Postives = 99/200 (49.50%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLG---HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSG-FLYSWGSNNYGQLGRDLTTSYESLPLMV 808
            CG  H++ L  +G+L+  G N   +LG          P  +Q L    +   SAG +H+ V++  G+VF WG NS G+LG     D F   +V+SL G   V ++CG +HT  L+K   +F++G+   GQLG  ++      P+ I  L    +  +T G   + V   S   +YS+G    GQLG       +S+PL V
Sbjct:  122 CGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLG-HNSLKDEHHPRLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVK-QSVPLPV 319          

HSP 5 Score: 85.8853 bits (211), Expect = 1.960e-16
Identity = 63/210 (30.00%), Postives = 104/210 (49.52%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVK--PNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSD-FSIKLVQSLTGHFIVQVACGHDHTLALTKNSE-IFSWGANTCGQLGLGDNFDMVSTPQQI---KNLSNLPIKSITAGDKFSFVL 712
            +F +G  ++GQLG+        S PQ +  +    + +IS G +H+  L  +G ++  G+N   +LG    K +  P  ++ L   K +  S G +H A ++  G VFT+G   FG+LG + L D    +L+  L G  + QV CG  HTL   ++S+ I+S+G    GQLG G+     S P  +      +   ++ +  G+  SF L
Sbjct:  136 LFVWGENTHGQLGLRKEQAGTQS-PQHLQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQ-SVPLPVLLPTECTEFTMEKLITGEHHSFAL 343          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Match: prxl2b (peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-968463])

HSP 1 Score: 634.024 bits (1634), Expect = 0.000e+0
Identity = 383/1067 (35.90%), Postives = 594/1067 (55.67%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYG-------GGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEI----NGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-----VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFH--------------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S+GQLG+   +++    P++ D   + ++  + CG  HT+F+L +G +Y+CG N+  +LGHD ++ KP Q+  LDA  ++  S G  H   + + G VF+WG   +G++G     ++ I++   ++SL+   IVQVACGH H+LAL+K+S+IFSWG N  GQLGLG        P+ IK+LS +P   I AG   SF LT SG ++ WG N +GQLG    T   ++P ++K LR Q I+++  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+QI CG  HTLA++ S+G +Y+FGLG  GQLG   T+    +   + G+W+  E +    + G+     +  VK ++         G    I A + +  K    D+  +  W        +N  +       +  +  I +V  S+     S  +   N  +  S    G+++++   ++ +          Q +A  ++ N+  ++    + P +ECLR +LI      +  +     + IPF  +   + + P   L  W   L+P  F K   ++ + + + +    NG      ++ F     +      L  LH++NE   +II Y+ FYI ++    D++  Y  W++      V+    ++  YPF+FD   KT L++ +A   M   +     Q++                + VRRDN++GD +  L +      KK  RV F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ESRL WF+   F+D+   F+ IG + GLAIYN  +I+LHFPL ++KKLL +K +L+DL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     ELI +G + PV   NRQ +VD YVDYI N++V   F  F  GFH     K L+ F+P ELQ +++G+ +YDW  L KS EY GEYW +H  I  FW  F +L  ++KK+FL +LTG DR+PI GM  +K+ IQP    + +LPVAHTC+NLLDLPKY+ +  LR KL  AI++ EGF+LV
Sbjct:    1 MLCWGNTSFGQLGLGGIDEEVVLEPRRCDFFINKNVRDVGCGSRHTVFVLDDGTVYTCGCNDLGQLGHDKSRRKPEQVGALDAQIIVAVSCGEAHTLALNDKGQVFSWGHAVYGQIGLSTAEEY-IRVPRNIKSLSDVQIVQVACGHHHSLALSKDSDIFSWGQNQYGQLGLGLEIKKECAPRHIKSLSGIPFAHIAAGGGHSFALTISGAIFGWGRNKFGQLGLTDETD-RNVPALLKSLRSQKIIHICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTINR-KSPFTVKGNWLTYE-DYVRHLPGKKHIHCITTVKGVFSMHFFQNSAGMLEDIVACNCNGIKIRTLDEGVIQRW--------LNYSLGR---LPLEIVNEIDKVFSSAACLNGSFLVTSNNDHYMTSSKFSGVDMNVARLLLHKLMDPSQPQIAQEVAASLEKNLIPRL--TSSPPDIECLRLYLILPECPPMADANNLTSLAIPFGTAIVNLEKAPLKVLENWWSLLEPPLFLKVVQLYKDVVVHLLKLSKNGIP-LTERRLFYRF--LNTALRVLEILHRVNEKAAQIIPYDKFYIHEVQDFVDIQNDYINWIKQQASGMVADPPVTICTYPFVFDAQAKTTLLQTDAVIQMQMAVDNAHRQNNLSWLFPATESVDPCLILVVRRDNIVGDAMEVLRKTKNIDYKKPMRVIFFGEEAIDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTFEDS-DLFHLIGVVCGLAIYNFTIIELHFPLALYKKLLKKKPSLEDLKELMPIIGRSMQQLLDYTEDDIEETFCLNFTITVENFGTTEVRELIPNGAEIPVNRKNRQDFVDAYVDYIFNQSVASLFSAFSAGFHKVCGSKVLELFQPNELQAMVIGNTAYDWKELEKSTEYKGEYWADHPTIKMFWEIFHALPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFLPVAHTCFNLLDLPKYSKKETLRSKLIQAIDHYEGFSLV 1046          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Match: prxl2b (peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-968463])

HSP 1 Score: 633.254 bits (1632), Expect = 0.000e+0
Identity = 383/1064 (36.00%), Postives = 588/1064 (55.26%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK----HPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEI----NGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-----VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFH--------------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S+GQLG+   +++    P++ D   + ++  + CG  HT+F+L +G +Y+CG N+  +LGHD ++ KP Q+  LDA  ++  S G  H   + + G VF+WG   +G++G     ++ I++   ++SL+   IVQVACGH H+LAL+K ++IFSWG N  GQLGLG        P+ IK+LS +P   I AG   SF LT SG ++ WG N +GQLG    T   ++P ++K LR Q I+++  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+QI CG  HTLA++ S+G +Y+FGLG  GQLG   T+    +   + G+W+  E                Y+  R+Y GG+ S     ++    +V+  D     W        NI      +   I++S + +     V                N  +  S    G+++++   ++ +          Q +A  ++ N+  ++    + P +ECLR +LI      +  +     + IPF  +   + + P   L  W   L+P  F K   ++ + + + +    NG      ++ F     +      L  LH++NE   +II Y+ FYI ++    D++  Y  W++      VS    ++  YPF+FD   KT L++ +A   M   +     Q++                + VRRDN++GD +  L +      KK  RV F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ESRL WF+   F+D+   F+ IG + GLAIYN  +I+LHFPL ++KKLL +K +L+DL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     ELI +G + PV   NRQ +VD YVDYI N++V   F  F  GFH     K L+ F+P ELQ +++G+ +YDW  L KS EY GEYW +H  I  FW  F +L  ++KK+FL +LTG DR+PI GM  +K+ IQP    + +LPVAHTC+NLLDLPKY+ +  LR KL  AI++ EGF+LV
Sbjct:    1 MLCWGNTSFGQLGLGGIDEEVVLEPRRCDFFINKNVRDVGCGSRHTVFVLDDGTVYTCGCNDLGQLGHDKSRRKPEQVGALDAQIIVAVSCGEAHTLALNDKGQVFSWGHAVYGQIGLSTAEEY-IRVPRNIKSLSDVQIVQVACGHHHSLALSKGNDIFSWGQNQYGQLGLGLEIKKECAPRHIKSLSGIPFAHIAAGGGHSFALTISGAIFGWGRNKFGQLGLTDETD-RNVPALLKSLRSQKIIHICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTINR-KSPFTVKGNWLTYE---------------DYV--RIYSGGDQSFAHYITI----QVWQGDCCKMQWAIFAASIVNIYHCYCLIIITIFSSAACLNGSFLVTS-------------NNDHYMTSSKFSGVDMNVARLLLHKLMDPSQPQIAQEVAASLEKNLIPRL--TSSPPDIECLRLYLILPECPPMADANNLTSLAIPFGTAIVNLEKAPLKVLENWWSLLEPPLFLKVVQLYKDVVVHLLKLSKNGIP-LTERRLFYRF--LNTALRVLEILHRVNEKAAQIIPYDKFYIHEVQDFVDIQNDYINWIKQQASGMVSDPPVTICTYPFVFDAQAKTTLLQTDAVIQMQMAVDNAHRQNNLSWLFPATESVDPCLILVVRRDNIVGDAMEVLRKTKNIDYKKPMRVIFFGEEAIDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTFEDS-DLFHLIGVVCGLAIYNFTIIELHFPLALYKKLLKKKPSLEDLKELMPIIGRSMQQLLDYTEDDIEETFCLNFTITVENFGTTEVRELIPNGAEIPVNRKNRQDFVDAYVDYIFNQSVASLFSAFSAGFHKVCGSKVLELFQPNELQAMVIGNTAYDWKELEKSTEYKGEYWADHPTIKMFWEIFHALPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFLPVAHTCFNLLDLPKYSKKETLRSKLIQAIDHYEGFSLV 1021          

HSP 2 Score: 51.6026 bits (122), Expect = 9.494e-6
Identity = 46/172 (26.74%), Postives = 83/172 (48.26%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDC--NKVKPNQIQMLDAHKLIDASAGYDHN-AVVTNLGLVFTWGKNSFGELGR----DKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTC 595
            +IF +G   +GQLG+   ++   + P  +  + S  I  I CG DHT  L K G +++ G   + +LGH+   ++V P ++  L    +   + G  H  A V + G ++++G    G+LG     ++ S F++K    LT    V++  G D + A     ++  W  + C
Sbjct:  210 AIFGWGRNKFGQLGLT--DETDRNVPALLKSLRSQKIIHICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTINRKSPFTVK-GNWLTYEDYVRIYSGGDQSFAHYITIQV--WQGDCC 376          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Match: prxl2b (peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-968463])

HSP 1 Score: 628.632 bits (1620), Expect = 0.000e+0
Identity = 379/1068 (35.49%), Postives = 587/1068 (54.96%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEI----NGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-------------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFH--------------ITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S+GQLG+   +++    P++ D   + ++  + CG  HT+F+L +G +Y+CG N+  +LGHD ++ KP Q+  LDA  ++  S G  H   + + G VF+WG   +G++G     ++ I++   ++SL+   IVQVACGH H+LAL+K+S+IFSWG N  GQLGLG        P+ IK+LS +P   I AG   SF LT SG ++ WG N +GQLG    T   ++P ++K LR Q I+++  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+QI CG  HTLA++ S+G +Y+FGLG  GQLG   T+    +   + G+W+  E +    + G+     +  VK ++    H  +T +   C K    D+  +  W        +N  +       ++                        N  +  S    G+++++   ++ +          Q +A  ++ N+  ++    + P +ECLR +LI      +  +     + IPF  +   + + P   L  W   L+P  F K   ++ + + + +    NG      ++ F   +        L  LH++NE   +II Y+ FYI ++    D++  Y  W++              V+    ++  YPF+FD   KT L++ +A   M   +     Q++                + VRRDN++GD +  L +      KK  RV F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ESRL WF+   F+D+   F+ IG + GLAIYN  +I+LHFPL ++KKLL +K +L+DL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     ELI +G + PV   NRQ +VD YVDYI N++V   F  F  GFH     K L+ F+P ELQ +++G+ +YDW  L KS EY GEYW +H  I  FW  F +L  ++KK+FL +LTG DR+PI GM  +K+ IQP    + +LPVAHTC+NLLDLPKY+ +  LR KL  AI++ EGF+LV
Sbjct:    1 MLCWGNTSFGQLGLGGIDEEVVLEPRRCDFFINKNVRDVGCGSRHTVFVLDDGTVYTCGCNDLGQLGHDKSRRKPEQVGALDAQIIVAVSCGEAHTLALNDKGQVFSWGHAVYGQIGLSTAEEY-IRVPRNIKSLSDVQIVQVACGHHHSLALSKDSDIFSWGQNQYGQLGLGLEIKKECAPRHIKSLSGIPFAHIAAGGGHSFALTISGAIFGWGRNKFGQLGLTDETD-RNVPALLKSLRSQKIIHICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTINR-KSPFTVKGNWLTYE-DYVRHLPGKKHIHCITTVKGVFS--MHFFVTQTK--CEKIRTLDEGVIQRW--------LNYSLGRLPLEIVNN-----------------------NDHYMTSSKFSGVDMNVARLLLHKLMDPSQPQIAQEVAASLEKNLIPRL--TSSPPDIECLRLYLILPECPPMADANNLTSLAIPFGTAIVNLEKAPLKVLENWWSLLEPPLFLKVVQLYKDVVVHLLKLSKNGIP-LTERRLFYRFLNT--ALRVLEILHRVNEKAAQIIPYDKFYIHEVQDFVDIQNDYINWIKQQASGMDVNHGLYEVADPPVTICTYPFVFDAQAKTTLLQTDAVIQMQMAVDNAHRQNNLSWLFPATESVDPCLILVVRRDNIVGDAMEVLRKTKNIDYKKPMRVIFFGEEAIDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTFEDS-DLFHLIGVVCGLAIYNFTIIELHFPLALYKKLLKKKPSLEDLKELMPIIGRSMQQLLDYTEDDIEETFCLNFTITVENFGTTEVRELIPNGAEIPVNRKNRQDFVDAYVDYIFNQSVASLFSAFSAGFHKVCGSKVLELFQPNELQAMVIGNTAYDWKELEKSTEYKGEYWADHPTIKMFWEIFHALPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFLPVAHTCFNLLDLPKYSKKETLRSKLIQAIDHYEGFSLV 1023          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Match: ENSXETT00000039332.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:100488790])

HSP 1 Score: 614.379 bits (1583), Expect = 0.000e+0
Identity = 369/1056 (34.94%), Postives = 595/1056 (56.34%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK-HPTNITVMNVDVNEPIY---TSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE-FSLFDYPFLFDGITKTNLMKIEAKCLMSEGL---------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G +++GQLG     +   S P       ++ +++++CG  HTLFLL++G++YSCG N   +LGHD     P Q+  L    +   + G  HN  ++  G +++WG  + G+LG   +   S   ++++ L    I QV+CG+DH +AL  + ++F+WG N  GQLGLG+ F   S+PQ++K+L  +P+  +TAG   SF L+ SG ++ WG+N+ GQLG +     E+ P  VK LR   ++Y+S G+ H A L+  GG+FT+G G  GQLGH++  N+  P  V++L+GS+VSQI CG  HTLA++ S+GT+YAFG G  GQLG      +   A  + G W      +  +IS         IVK+++ GGN + +  S L+  +    DD R  + + H + I    +DV        ++ ++M  I + L S      S      +  F  S    G+N+     +  +  +   S  L+ +    +  +  Q+  + + P +E +R ++I     +L+ S++   + +P +++   +   PS  L+ W   + P+YF K   ++  A+   +NG +       F+  I        L KLH++N     + H +TFYIP+I  + D++  Y +W  N + ++  +L  YPF+FD   KT +++ +A+  M   +               P  +      + VRR +L+ D + +L   +   LKK  +V F GE+A+D+GGV KE FLL++ ++LNP YG+F +Y +S L WF+ + F ++   F+ IG + GLAIYN  ++DL+FPL ++KKLLN +  L+DL EL+PT G+SLQ LLDY ++D +D+F LNF +  E YG      L+  G    VT  NRQ +VD YV+Y+ N++V++ ++ F  GF     GK L+ F+P EL+ ++VGS +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GMS ++I IQ ++  +++LPVAHTCYNLLDLPKY+S+  LR +L  AI++ EGF+L 
Sbjct:    1 MLCWGHSTFGQLGNGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQLGHDHEGTDPVQVTTLTEEHITHIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQKIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRET-PCHVKPLRTHKVIYISCGEEHTAILTKAGGLFTFGAGGSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFGCGDLGQLGTGHKNNVKCPAV-VKGKWAA----HSGQISMHADRAAYNIVKQIFSGGNKTFVLCSKLESSQPA--DDFRFCSQRNHTSVINEETIDVWRQKVLENSNTNSMNGIVQTLSSLACWNGSFLEKRNDEHFRTSPKIPGINMCSIKVLFEKLMNVHHSRLLEQILKGFESFLIPQL--SSSPPDVEAMRIYIILPEFPLLQDSKYYITLTLPLAMAILRLDTNPSKVLDNWWAQVCPKYFLKLISLYKEAVVYLLNGRKTLLIPVLFTSYI--TAALKLLEKLHKVNGKAQHVEH-DTFYIPEISSLVDIQEDYLMWFLNEAGLDSITLCSYPFVFDAQAKTKMLQTDAELQMQVAINGANLQNVFMLLTLDPMLVKNPFLVLHVRRTSLVADALRELSIYSDIDLKKPLKVIFDGEEAVDDGGVTKEFFLLLLKELLNPIYGMFTVYQDSNLLWFSDICFVEH-NWFHLIGIMCGLAIYNFTVVDLYFPLALYKKLLNVQPTLEDLKELSPTEGRSLQELLDYPEDDVDDVFCLNFTICRESYGLAERKPLVAGGDHITVTKDNRQQFVDAYVNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMVVGSNNYNWQELEENAIYKGDYSTAHPTVRMFWETFHDFPLEKKKKFLLFLTGSDRIPIYGMSSLRIIIQSISSGEDHLPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHYEGFSLA 1042          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Match: ENSXETT00000027632.1 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:100488790])

HSP 1 Score: 611.683 bits (1576), Expect = 0.000e+0
Identity = 369/1064 (34.68%), Postives = 595/1064 (55.92%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK-HPTNITVMNVDVNEPIY---TSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF---------SLFDYPFLFDGITKTNLMKIEAKCLMSEGL---------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G +++GQLG     +   S P       ++ +++++CG  HTLFLL++G++YSCG N   +LGHD     P Q+  L    +   + G  HN  ++  G +++WG  + G+LG   +   S   ++++ L    I QV+CG+DH +AL  + ++F+WG N  GQLGLG+ F   S+PQ++K+L  +P+  +TAG   SF L+ SG ++ WG+N+ GQLG +     E+ P  VK LR   ++Y+S G+ H A L+  GG+FT+G G  GQLGH++  N+  P  V++L+GS+VSQI CG  HTLA++ S+GT+YAFG G  GQLG      +   A  + G W      +  +IS         IVK+++ GGN + +  S L+  +    DD R  + + H + I    +DV        ++ ++M  I + L S      S      +  F  S    G+N+     +  +  +   S  L+ +    +  +  Q+  + + P +E +R ++I     +L+ S++   + +P +++   +   PS  L+ W   + P+YF K   ++  A+   +NG +       F+  I        L KLH++N     + H +TFYIP+I  + D++  Y +W  N + ++          +L  YPF+FD   KT +++ +A+  M   +               P  +      + VRR +L+ D + +L   +   LKK  +V F GE+A+D+GGV KE FLL++ ++LNP YG+F +Y +S L WF+ + F ++   F+ IG + GLAIYN  ++DL+FPL ++KKLLN +  L+DL EL+PT G+SLQ LLDY ++D +D+F LNF +  E YG      L+  G    VT  NRQ +VD YV+Y+ N++V++ ++ F  GF     GK L+ F+P EL+ ++VGS +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GMS ++I IQ ++  +++LPVAHTCYNLLDLPKY+S+  LR +L  AI++ EGF+L 
Sbjct:    1 MLCWGHSTFGQLGNGHSFQGSVSDPCVCRFSLAACVKEVACGGKHTLFLLEDGQVYSCGWNGEGQLGHDHEGTDPVQVTTLTEEHITHIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQKIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFALSLSGAVFGWGNNSAGQLGLNDEKVRET-PCHVKPLRTHKVIYISCGEEHTAILTKAGGLFTFGAGGSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFGCGDLGQLGTGHKNNVKCPAV-VKGKWAA----HSGQISMHADRAAYNIVKQIFSGGNKTFVLCSKLESSQPA--DDFRFCSQRNHTSVINEETIDVWRQKVLENSNTNSMNGIVQTLSSLACWNGSFLEKRNDEHFRTSPKIPGINMCSIKVLFEKLMNVHHSRLLEQILKGFESFLIPQL--SSSPPDVEAMRIYIILPEFPLLQDSKYYITLTLPLAMAILRLDTNPSKVLDNWWAQVCPKYFLKLISLYKEAVVYLLNGRKTLLIPVLFTSYI--TAALKLLEKLHKVNGKAQHVEH-DTFYIPEISSLVDIQEDYLMWFLNEAGLKLRPTIMQDSITLCSYPFVFDAQAKTKMLQTDAELQMQVAINGANLQNVFMLLTLDPMLVKNPFLVLHVRRTSLVADALRELSIYSDIDLKKPLKVIFDGEEAVDDGGVTKEFFLLLLKELLNPIYGMFTVYQDSNLLWFSDICFVEH-NWFHLIGIMCGLAIYNFTVVDLYFPLALYKKLLNVQPTLEDLKELSPTEGRSLQELLDYPEDDVDDVFCLNFTICRESYGLAERKPLVAGGDHITVTKDNRQQFVDAYVNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMVVGSNNYNWQELEENAIYKGDYSTAHPTVRMFWETFHDFPLEKKKKFLLFLTGSDRIPIYGMSSLRIIIQSISSGEDHLPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHYEGFSLA 1050          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Match: Herc4 (hect domain and RLD 4 [Source:MGI Symbol;Acc:MGI:1914595])

HSP 1 Score: 659.833 bits (1701), Expect = 0.000e+0
Identity = 393/1080 (36.39%), Postives = 603/1080 (55.83%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-----VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P++ D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  + G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ IK+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+Q+ CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W     +   +   +  +E  + VKR++ GG+ S    SS  +CG    PDD R       ++ +     VNE +   + S  + +   E+        SSS   +  S   IS  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++        I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   ++I Y+ FYI ++ ++ D+   Y  W++      ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL  K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW +H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     ++YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWF----SYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 1049          

HSP 2 Score: 92.0485 bits (227), Expect = 3.129e-18
Identity = 68/230 (29.57%), Postives = 109/230 (47.39%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDNFDMVS--------------TPQQIKNLSNLPIKSITAGDKFSF 706
            +  + + K   +F +G   YGQLG+    +   S PQ I  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + QVACG  HT A   +S  I+S+G    GQLG G   +  S               PQ I +     +K I +G   SF
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSF 375          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Match: Herc4 (hect domain and RLD 4 [Source:MGI Symbol;Acc:MGI:1914595])

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 393/1088 (36.12%), Postives = 603/1088 (55.42%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-------------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P++ D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  + G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ IK+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+Q+ CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W     +   +   +  +E  + VKR++ GG+ S    SS  +CG    PDD R       ++ +     VNE +   + S  + +   E+        SSS   +  S   IS  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++        I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   ++I Y+ FYI ++ ++ D+   Y  W++              ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL  K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW +H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     ++YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWF----SYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 1057          

HSP 2 Score: 91.6633 bits (226), Expect = 3.511e-18
Identity = 68/230 (29.57%), Postives = 109/230 (47.39%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDNFDMVS--------------TPQQIKNLSNLPIKSITAGDKFSF 706
            +  + + K   +F +G   YGQLG+    +   S PQ I  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + QVACG  HT A   +S  I+S+G    GQLG G   +  S               PQ I +     +K I +G   SF
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSF 375          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Match: Herc3 (hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1921248])

HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0
Identity = 380/1066 (35.65%), Postives = 592/1066 (55.53%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---------FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S GQ GI    +   + PQ    +S   I++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA + S+G +YAFG G  GQLG   T  +     P+ GHW      + S++S      +  +VK+++ GG+ + +  S+ +        D R  N  H TN      I V    + E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +   SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W     P+YF K   ++  A+   + G +       F++   M      L KL+++N     +  Y+ FYIP+I  + D++  Y +W  + S ++          +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR++L+GD + +L   +   LKK  +V F GE+ +D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K +L+DL EL+PT G+SLQ LLDY   D E+ F LNF V  E YG   + +LI  G    V   NRQ +VD YV+YI   +V + +  F  GF     GK L+ F+P EL+ +MVG+ +YDW  L ++  Y G+Y + H  +  FW +F     ++KKKFL +LTG DR+PI GM+ ++I IQ     + YLPVAHTCYNLLDLPKY+S+ I++ +L  A++N EGF+L 
Sbjct:    1 MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCNV-KCPSPVKGHWAA----HSSQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAV--DFRTVNQTHYTNLINDETIAVWRQKLTE--HNNANTVNGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGAVLYLLRGRKTFLIPVLFNNY--MTATLKLLEKLYKVNLKVKHV-EYDKFYIPEISSLVDIQEDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSLA 1050          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Match: Herc3 (hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1921248])

HSP 1 Score: 479.174 bits (1232), Expect = 5.609e-152
Identity = 306/904 (33.85%), Postives = 485/904 (53.65%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---------FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQT 2719
            +  +G  S GQ GI    +   + PQ    +S   I++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA + S+G +YAFG G  GQLG   T  +     P+ GHW      + S++S      +  +VK+++ GG+ + +  S+ +        D R  N  H TN      I V    + E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +   SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W     P+YF K   ++  A+   + G +       F++   M      L KL+++N      + Y+ FYIP+I  + D++  Y +W  + S ++          +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR++L+GD + +L   +   LKK  +V F GE+ +D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K +L+DL EL+PT G+SLQ LLDY   D E+ F LNF V  E YG   + +LI  G    V   NRQ 
Sbjct:    1 MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCNV-KCPSPVKGHWAA----HSSQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAV--DFRTVNQTHYTNLINDETIAVWRQKLTE--HNNANTVNGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGAVLYLLRGRKTFLIPVLFNNY--MTATLKLLEKLYKVNLKVKH-VEYDKFYIPEISSLVDIQEDYLMWFLHQSGMKARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQA 888          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Match: Herc6 (hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1914388])

HSP 1 Score: 386.726 bits (992), Expect = 1.894e-116
Identity = 297/1027 (28.92%), Postives = 510/1027 (49.66%), Query Frame = 2
Query:  227 GFDHTLFLLKNGKLYSCGNNEFKKLGH--DCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESL--PLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMY--IVKRLYGGGNHSIITAS------SLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLN--IDLTFNIMSQFFSSQSSD-YLQTLAVR-MKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEY-SYELWLRN-----VSKIEFSLF-DYPFLFDGITKTNLMKIEAKC-LMSE--GLPCFMAQSSFHI-TVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNA-----IGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKI---QPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGF 3196
            G  H+L L  N ++YSCG+N + +LG   D +  +P  IQ L+   +   S G +H+  V + G VF WG  S G+LG  +  + S     +++L G  I+QV+CGH H+LAL+++  +FSWG N+ GQLGLG N    + PQ++K+L  +P+  + AG   SF L+ +G  + WGSN  GQL        E +  P  +  L+   ++Y+S G  H A L+ +G VFT+G    GQL  +    +  P ++ + +G +VSQIEC   HT+AY+ +TG V + G G              HT+ P +    P E    S I+    AE +    VK ++ G + + +T        S     K+ P+ +R                +N+ +           +   +              +   + + + G N  ID+   +    F   +++ ++ +L    +++ +   + Y+   P  E L  FL+    +I++  +  K +   F+ +   +       L     +L+         +   AI ++I    G  T++  ++I   K + + + ++H+ N      +  + F I ++  +F+ +  +  +++R+         +  +F D+ F+FD  +K  LMK ++   LMSE    P  M+   + I  VRR +L+ DT+ QL +     L+K   V F+ E   + GGV  E F  +  ++ +P Y +F +YPE      + M F  N P+F        G L GL+++N  +I+L FPL ++KKLLN+K +L+DL EL+  LG++LQ +L+ +  D E++ M   I     Y ++ + +LI DG   PV  +N++ YV  YVDYI N +++  ++ F  GF+       ++ F+P EL   ++G+ + DW     + +Y   Y  +H  I  FW +F  L+ DEKKKFL +LTGCDR+ + G+ +  I     +  + +DN  P + TC+ +LDLPKY+S   +++ L++AI N+ GF
Sbjct:   30 GEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLI-EGIGGRVSQIECASYHTIAYVYTTGQVVSLGRGP------------SHTSNPTHQE-APAE---NSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKILPEIIR----------------INQSLVKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAGENNLIDVDLKLARDVFKKLTTEKWISSLITTCLEEYLLRDLPYSS--PHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRTCWASLEVSSLNILVQMLKKAIISQIQ--YGVATEQYITNI---KVLLEVIKEVHKANCQ----LPESAFIINELSGIFNFDAEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLMKCDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMF-IYPEKG----SSMWFPVN-PKFEKSSYFLFGILCGLSLHNLKVINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEELHMYFSI-----YWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDN--PRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGF 999          

HSP 2 Score: 142.124 bits (357), Expect = 9.564e-34
Identity = 85/258 (32.95%), Postives = 137/258 (53.10%), Query Frame = 2
Query:  323 KPNQIQM-LDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG-RDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQL---GHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQL 1081
            KP +++      +L+ A++G  H+ ++ +   V++ G NS+G+LG R   S    + +Q+L    +  V+CG +H++A+    ++F+WGA + GQLG+G+  ++   P +IK L+ + I  ++ G   S  L+  G ++SWG N+ GQLG    +  +++P  VK L   P+  V+ G  H  ALS+ G  F WG  R GQL   G+   E    P  +  L    V  I CG  HT A +   G V+ FG    GQL
Sbjct:   11 KPRRLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHT-AVLTEEGQVFTFGGNSSGQL 267          

HSP 3 Score: 113.235 bits (282), Expect = 9.271e-25
Identity = 67/203 (33.00%), Postives = 106/203 (52.22%), Query Frame = 2
Query:  482 KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLG-HNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGI 1087
            +L    +G  ++Q A G  H+L L  N  ++S G N+ GQLG   +      P+ I+ L++L +  ++ G + S  +   G +++WG+ + GQLG         +P  +K L    I+ VS G  H  ALS DG VF+WG    GQLG   N  +++IP  V  L G  ++Q+  G  H+ A  + TGT + +G  + GQL +
Sbjct:   14 RLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRD-QSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSL-TGTSFGWGSNRSGQLAL 214          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Match: sp|Q6PAV2|HERC4_MOUSE (Probable E3 ubiquitin-protein ligase HERC4 OS=Mus musculus OX=10090 GN=Herc4 PE=1 SV=2)

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 393/1088 (36.12%), Postives = 603/1088 (55.42%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-------------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P++ D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  + G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ IK+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+Q+ CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W     +   +   +  +E  + VKR++ GG+ S    SS  +CG    PDD R       ++ +     VNE +   + S  + +   E+        SSS   +  S   IS  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++        I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   ++I Y+ FYI ++ ++ D+   Y  W++              ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL  K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW +H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     ++YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWF----SYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 1057          

HSP 2 Score: 91.6633 bits (226), Expect = 2.456e-17
Identity = 68/230 (29.57%), Postives = 109/230 (47.39%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDNFDMVS--------------TPQQIKNLSNLPIKSITAGDKFSF 706
            +  + + K   +F +G   YGQLG+    +   S PQ I  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + QVACG  HT A   +S  I+S+G    GQLG G   +  S               PQ I +     +K I +G   SF
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSF 375          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Match: sp|Q5PQN1|HERC4_RAT (Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus OX=10116 GN=Herc4 PE=2 SV=1)

HSP 1 Score: 654.44 bits (1687), Expect = 0.000e+0
Identity = 395/1088 (36.31%), Postives = 600/1088 (55.15%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-------------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P+K D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG      ++PQ IK+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+QI CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W     +   +   +  +E  + VKR++ GG+ S    SS   CG    PDD R       ++ +     VNE +   + S  + +   E+        SSS   +  S   +S  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++        I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   ++I Y+ FYI ++ ++ D+   Y  W++              ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL  K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     ++YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVLEPRKSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLQG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIECQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWF----SYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQSCGP---PDDFRR------SDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHRLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNERTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGITELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 1057          

HSP 2 Score: 92.0485 bits (227), Expect = 2.125e-17
Identity = 67/230 (29.13%), Postives = 109/230 (47.39%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDNFDMVST--------------PQQIKNLSNLPIKSITAGDKFSF 706
            +  + + K   +F +G   YGQLG+    +   S PQ I  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + Q+ACG  HT A   +S  I+S+G    GQLG G   +  S               PQ I +     +K I +G   SF
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGIECQKQTS-PQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSF 375          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Match: sp|Q5GLZ8|HERC4_HUMAN (Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1)

HSP 1 Score: 642.499 bits (1656), Expect = 0.000e+0
Identity = 399/1088 (36.67%), Postives = 601/1088 (55.24%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASS-LDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFE---GQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELW-------------LRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G AS+GQLG+   +++    P+K D   +  +  + CG  HT+F+L +G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G V+ WG +S G+LG    S+  I++   ++SL+   IVQVACG+ H+LAL+K SE+F WG N  GQLGLG +    ++PQ +K+L  +P   + AG   SFVLT SG ++ WG N +GQLG  D    Y  +P ++K LR Q IVY+  G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V++I CG  HT A++ S+G +Y+FGLG  GQLG   T    +   P  + G+W P        I     +E+ + VKR++ GG+ S    SS  +CG    PDD R        N T     VNE +   + S  + +   E+        SSS   +  S   +S  +H        G++++    +  +          Q +A  ++ N+  ++    + P +E LRF+L      ++  S     I IPF  +   + + P   L  W   L+P  F K   +F   + + +  ++     + ++ F+  +        L  LH++NE   +II Y+ FYI ++ ++ D+   Y  W             L  ++ I  ++  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GD +  L +      KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  Y +SRL WF+   F+D+   F+ IG + GLAIYN  ++DLHFPL ++KKLL +K +LDDL EL P +G+S+Q LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +VD YVDYI NK+V   F  F  GFH    GK L  F+P ELQ +++G+ +YDW  L K+ EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQ     + YLPV+HTC+NLLDLPKYT +  LR KL  AI++NEGF+L+
Sbjct:    1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG-SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVKGNWYPYNGQCLPDID----SEEYFCVKRIFSGGDQSFSHYSSPQNCGP---PDDFRC------PNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGC-LNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKL--TSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHT--ALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLI------LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS-DLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 1057          

HSP 2 Score: 90.8929 bits (224), Expect = 4.233e-17
Identity = 57/185 (30.81%), Postives = 96/185 (51.89%), Query Frame = 2
Query:   71 FEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLG 613
            +  + + K   +F +G   YGQLG+    K   S PQ +  +      +++ G  H+  L  +G ++  G N+F +LG   + ++  PN ++ L + K++    G DH A +T  G VFT+G   +G+LG +  S + + + V  L G  + ++ACG  HT A   +S  I+S+G    GQLG G
Sbjct:  147 YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330          

HSP 3 Score: 55.4546 bits (132), Expect = 3.634e-6
Identity = 39/135 (28.89%), Postives = 71/135 (52.59%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHD--CNKVKPNQIQMLDAHKLIDASAGYDH-NAVVTNLGLVFTWGKNSFGELG----RDKLSDFSIK 484
            +IF +G   +GQLG++  N  Y   P  +  + S  I  I CG DHT  L K G +++ G   + +LGH+   +++ P ++  L    + + + G  H +A V + G ++++G    G+LG     ++ S F++K
Sbjct:  210 AIFGWGRNKFGQLGLNDENDRY--VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Match: sp|Q15034|HERC3_HUMAN (Probable E3 ubiquitin-protein ligase HERC3 OS=Homo sapiens OX=9606 GN=HERC3 PE=1 SV=1)

HSP 1 Score: 617.846 bits (1592), Expect = 0.000e+0
Identity = 378/1066 (35.46%), Postives = 595/1066 (55.82%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI--KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTN------ITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---------FSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G  S GQ GI    +   + PQ    IS   +++++CG +H++FLL++G++Y+CG N   +LGH+    KP QI  L    +I  + G  H+  +++ G +F+WG  S G+LG     D     +L+Q L    I+QV+CG+ H LAL  + + F+WG N+ GQLGLG  F   ++PQ++++L  +P+  + AG   SF L+ SG ++ WG NN GQLG       ES P  VK LR Q +VY+S G+ H A L+  GGVFT+G G  GQLGH++  ++  P  V++L+GS+V+QI CG  HTLA++ S+G +YAFG G  GQLG   T  +     P+ G+W      +  ++S      + +IVK+++ GG+ + +  S  +        D R  N  H T+      I V    ++E  + + +T+  + ++L S+     S      +  F  S    G++++ T  +  +  +SQ S  L+ +    +  +  Q+  + + P +E +R +LI     +L+ S++   + IP +++   +   PS  L+ W   + P+YF K   ++  A+   + G +       F++ I        L KL+++N     +  Y+TFYIP+I  + D++  Y +W  + + ++          +L  YPF+FD   KT +++ +A+  M                 L   +A+S F +  VRR+NL+GD + +L   +   LKK  +V F GE+A+D GGV KE FLL++ ++LNP YG+F  Y +S L WF+   F ++   F+ IG   GLAIYN+ ++DLHFPL ++KKLLN K  L+DL EL+PT G+SLQ LLDY   D E+ F LNF +  E YG   + +LI  G +  V   NRQ +VD YV+Y+   +V + +  F  GF     GK L+ F+P EL+ +MVG+ +Y+W  L ++  Y G+Y   H  +  FW +F     ++KKKFL +LTG DR+PI GM+ ++I IQ     + YLPVAHTCYNLLDLPKY+S+ IL  +L  A++N EGF+L 
Sbjct:    1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNV-KCPSPVKGYWAA----HSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAV--DFRTMNQAHYTSLINDETIAVWRQKLSE--HNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQL--SSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYI--TAALKLLEKLYKVNLKVKHV-EYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1050          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Match: sp|Q9UII4|HERC5_HUMAN (E3 ISG15--protein ligase HERC5 OS=Homo sapiens OX=9606 GN=HERC5 PE=1 SV=2)

HSP 1 Score: 418.698 bits (1075), Expect = 3.214e-127
Identity = 300/1003 (29.91%), Postives = 507/1003 (50.55%), Query Frame = 2
Query:  326 PNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDI-------KNSVFHISQTNHGLNIDLTFNIMSQFFS--SQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGF-EGQNTKKKFSDIIEMKPVFDCLCKLHQINE----------DHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE-------FSLFDYPFLFDGITKT------NLMKIEAK---------CLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLC-WFN-KMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPV-AHTCYNLLDLPKYTSESILRDKLKIAIENNEGFA 3199
            P  I++    K+     G +H  ++++ G  F +          D  S   ++    L    I+Q+ CG  H+LAL+K  E+F+WG N  GQLG+G  F   +TPQ +++L+ +P+  I+AG+  S  L+ SG +YSWG N  GQLG   T S +  P +++ L  Q + +V+ G +H A L+ DG +FT+G G++GQLGHN+ +N+  PC+V +L+G +V+QI CG  HTLAY+   G V++FG GK GQLG   T +      P+    V +  + + K+   T+ +++ ++     GGN SI+                 LW  K  + +   N+    P     +  + I++V             +I         S     +T   + + L  N     F   +Q       +   +KDN+  ++ ++   P  E L  F +     ++ IS   + +++PF+     + +  S+ L ++   L+   F K   +F  A+  +++ + E          ++EM      L KLH++N+            + ++H   F++    +         LW   V   E       FS F  PF+F+ ++K        L+KIE+K          +  E    F  + +F +TVRR++L+ D ++QL +     L+K   V+F GE   D GGV KE F  +  +++ P+YG+F MYPE   C WF  K  F+    ++   G L GL+++N  + +L FPL +FKKLL++  +L+DL EL+P LGK+LQ LLD + ++FE++F ++F V    + ++ +  LI +G    V  +N++ YV  Y++YI N +V+  ++ F+ GF+       +K F P EL++++VG+  YDW    K+  Y   Y ++H  I  FW +F  L+ +EKKKFL +LTG DR+ +  ++++KI        +   P+ A TC+++L LPKY++   + + L+ AI NN GF 
Sbjct:   88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEY----------DNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDD-PSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRD---QLMPLP---VKVSSSEELKLESHTSEKELIMI----AGGNQSIL-----------------LWIKKENSYV---NLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLPFHS--PPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQLDYWDESAEENGNVQALLEM------LKKLHRVNQVKCQLPESIFQVDELLHRLNFFVEVCRRY--------LWKMTVDASENVQCCVIFSHF--PFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMF-MYPEGASCMWFPVKPKFEKK--RYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNV----HWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024          

HSP 2 Score: 98.5969 bits (244), Expect = 1.959e-19
Identity = 73/245 (29.80%), Postives = 130/245 (53.06%), Query Frame = 2
Query:   68 NFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKL-SDFSIKLVQSLTGHFIVQVACGHDHTLALTKN-SEIFSWGANTCGQLGLGDNFD-MVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSW--GSNNYGQLGRDLTT 781
            ++  + + K   +F++G   +GQLG+  R     + PQ ++ ++   + +IS G  H++ L  +G +YS G NE  +LG  H  +K  P+ I+ LD  K+   + G  H+A++T  GL+FT+G    G+LG +   ++    LV  L G+ + Q+ACG  HTLA   +  ++FS+G+   GQLG G   D ++  P ++ +   L ++S T+  +   +   +  +  W    N+Y  L R + T
Sbjct:  147 DYHSLALSKGGELFAWGQNLHGQLGVG-RKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPT 390          

HSP 3 Score: 80.1073 bits (196), Expect = 9.234e-14
Identity = 61/201 (30.35%), Postives = 97/201 (48.26%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHD---CNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKL-SDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFV-LTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVK 811
            CG  H+L L K G+L++ G N   +LG      +   P  ++ L    L   SAG  H+  ++  G +++WGKN  G+LG     S     L++ L    +  VACG  H+  LT++  +F++GA   GQLG     + +  P  +  L    +  I  G   +   ++  G ++S+GS   GQLG   T   + +PL VK
Sbjct:  145 CGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRD-QLMPLPVK 343          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Match: A0A094ZME9 (Putative E3 ubiquitin-protein ligase HERC4 OS=Schistosoma haematobium OX=6185 GN=MS3_04099 PE=4 SV=1)

HSP 1 Score: 721.079 bits (1860), Expect = 0.000e+0
Identity = 442/1173 (37.68%), Postives = 643/1173 (54.82%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLG-DNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG------------RDLTTSYES---------------------------LPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFE-NKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNN--QSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNE-------------PIYTSIS----------------TMKSISEVXXXXXXXXXXXXXDIK----NSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTIL----------EISEFCK-------------------------VILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---FSLFDYPFLFDGITKTNLMKIEAK-----------------CLMSEGLPCFMAQSS-----FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYG-NKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQ-IIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +F++G+   GQL +D  +      P+ +D  +     +I+CG+ HT+FL  +G++YSCG NEF++LGH     +  ++  L+ +++I  + G  HNA +T  GL+FTWG NS G+LGR+   D  +KLV++L+ H +VQV+ G +HTL LT  + +FS+G+N  GQLGLG  +   +S PQQI  LS LP++ I AG   SFVLT SG LY+WGSNNYGQLG             +LT +Y S                           +P  VK LR   IVY++ G+ H  AL+ DGGVFT+G GRYGQLGHN      S+P  + + +G+ V+QI CG  HTLA +  TG ++AFG G   QLG+ DT        PI GHWV     N  +S +  ++++ + Y+++R++ GG+H+ + A     G+ V  DDLR WN     +I  +  ++ E             PI   IS                 M  +S+V     +    S   ++    NS F   +  HG+++DL   + SQ F       L+ L  ++ D++ S  +   NYPS+ECLR  +  AVS +L           +S+  K                         ++L  +SV+ + +   PS  L++W   ++PRY KK  +   N I+  ++        ++      ++   + + +LH++NE+H   I YN+FY+P +    ++  ++  WL+  +      FS  DYPF+FD  +K  ++ IEA+                  L+S  +   M         F I VRRDN+L DT+S L  A     KK  RV F  E+A+DEGGVMKE FLLV+  +LNP YG+F  Y ESR+ WF++   + +N+  F  +G L GLAIYN++++DL FPL MF+KLL E   LDDL EL+P +G+SLQ LLDYD  D  D+F LNF V+++ +G NKI   L+ DG +  VT  N+  YV+ YV+Y+  K+ E P+K F++GF     G  LK F+P ELQ L+VGSE  +W  LR++  Y G YW+ HQ II ++       + +EKKKFLR+LTGCDRVPI G S +KI IQP N  D++LPVAHTC NLLDLP+Y+ + IL  KL +AI+  EGF LV
Sbjct:    9 LFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTFIQITCGYAHTVFLTVDGEVYSCGCNEFQQLGHGQAGGQLAKVVALEHYRIISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG-DDTGVKLVRALSDHKVVQVSLGVEHTLVLTDTARVFSFGSNLKGQLGLGFSSEQSISIPQQILCLSGLPVRRIVAGGWHSFVLTVSGSLYAWGSNNYGQLGLSYFGSSPKDHQNELTLTYGSVGSTSVDDEQSKDRPFSLLDTSLSNVSIPTFVKTLRGCEIVYLACGEAHTVALTRDGGVFTFGAGRYGQLGHNESTIGISVPRKITEFMGNVVTQIACGRFHTLALVPKTGRLFAFGQGANAQLGMGDTTNRLLPC-PIKGHWVSSHKLNSKESTVGTDSSSSKPYVIRRIFSGGDHTFLLAQLYQTGEIVDADDLRNWNRSSLQSILTVCPEIVEQLRSAHTALALPPPISRCISLSSSRPLTSLSSTSNEPMAIVSKVESVYSSLGCLSASCLEEKEPNSHFKTGREEHGVDLDLACTLQSQIFHILPKRDLKRLINKLLDDVLSTSRL--NYPSIECLRGLMFIAVSDLLNMPRKPIIDEAVSDVNKMDITSEMNTNFEPYPVLSAGFSTPGLVLNAYSVAINRLDPAPSKILDRWFTKMQPRYLKKLVLNLNNLISYILDMQPASAYSQRKLKEESIRQALEFMKRLHRVNENHPNPISYNSFYLPSLKDKINIGSAFVNWLQECNSGGMRFFSFCDYPFVFDAASKAEMLNIEARLTMQQAMSQAQQSAIFQSLLSPFIGSRMYDGGTTSPYFTIIVRRDNILQDTLSNLTMANPADFKKLLRVKFENEEAVDEGGVMKEFFLLVMRDLLNPVYGMFRCYSESRMLWFSESTMESENV--FLMVGILCGLAIYNSIIVDLSFPLAMFRKLLGETPGLDDLKELDPIVGRSLQQLLDYDNADLADVFCLNFTVTIDYFGVNKI-IPLMEDGENMIVTQENKSLYVEKYVEYVFQKSCETPYKAFEKGFLQVCGGYSLKLFQPSELQSLVVGSEVVNWDELRQNTTYQGVYWDRHQVIIWFWDVLLYDFTIEEKKKFLRFLTGCDRVPIVGFSGVKITIQPNNSGDDFLPVAHTCANLLDLPQYSCKEILAKKLSLAIQQTEGFGLV 1174          

HSP 2 Score: 85.1149 bits (209), Expect = 9.347e-13
Identity = 71/248 (28.63%), Postives = 124/248 (50.00%), Query Frame = 2
Query:   80 IIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG--HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSI-KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTP-SGFLYSWGSNNYGQLGRDLTTSYESLPLMVK 811
            +++     +FSFG+   GQLG+   ++   S PQ+I  +S   + +I  G  H+  L  +G LY+ G+N + +LG  +  +  K +Q ++   +  + +++  D  +      L+ T             LS+ SI   V++L G  IV +ACG  HT+ALT++  +F++GA   GQLG  ++   +S P++I       +  I  G   +  L P +G L+++G     QLG   TT+   LP  +K
Sbjct:  155 LVLTDTARVFSFGSNLKGQLGLGFSSEQSISIPQQILCLSGLPVRRIVAGGWHSFVLTVSGSLYAWGSNNYGQLGLSYFGSSPKDHQNELTLTYGSVGSTSVDDEQSKDRPFSLLDT------------SLSNVSIPTFVKTLRGCEIVYLACGEAHTVALTRDGGVFTFGAGRYGQLGHNESTIGISVPRKITEFMGNVVTQIACGRFHTLALVPKTGRLFAFGQGANAQLGMGDTTN-RLLPCPIK 389          

HSP 3 Score: 80.4925 bits (197), Expect = 2.235e-11
Identity = 59/179 (32.96%), Postives = 88/179 (49.16%), Query Frame = 2
Query:  554 TKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPI-KSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGI 1087
            +   E+F+WG+   GQL L  N        +  ++ NLP    IT G   +  LT  G +YS G N + QLG        +  + ++H R   I+ V+ G  H AA++ +G +FTWG    GQLG     + +   +V  L   KV Q+  G+ HTL  +  T  V++FG    GQLG+
Sbjct:    4 SSTEELFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTFIQITCGYAHTVFLTVDGEVYSCGCNEFQQLGHGQAGGQLAKVVALEHYR---IISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG--DDTGVKLVRALSDHKVVQVSLGVEHTLV-LTDTARVFSFGSNLKGQLGL 176          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Match: A0A5K4EPN5 (Putative hect E3 ubiquitin ligase OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 719.924 bits (1857), Expect = 0.000e+0
Identity = 443/1197 (37.01%), Postives = 655/1197 (54.72%), Query Frame = 2
Query:   65 LNFEFI--IILK----MIS-----IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDM-VSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGR---------------------------------------DLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFE-NKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQS--KISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSIS---------------------------TMKSISEVXXXXXXXXXXXXXDIK----NSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEI---------------------------------SEFCK--VILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---FSLFDYPFLFDGITKTNLMKIEAK-----------------CLMSEGLPCFMAQSS-----FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQ-IIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            LNF FI  ++L     M+S     +F++G+   GQL +D  +      P+ +D  +   + +I+CG+ HT+FL  +G++YSCG NEF++LGH  +  +  ++  L+ +++I  + G  HNA +T  GL+FTWG NS G+LGR+   D  +KLV++L+ H +VQV+ G +HTL LT  + +F++G+N  GQLGLG + +  VS PQQI  LS LP++ I AG   SFVLT SG LY+WGSNNYGQLG                                        D + S  S+P  VK LR   +VY++ G+ H  AL+ DGGVFT+G GRYGQLGHN      S+P  + + +G+ V+QI CG  HTLA +  TG ++AFG G   QLG+ DT        P+ GHWV    ++ +   +  ++++ + YI++R++ GG+H+ + A     G+ V PDDLR WN     +I  +  ++ E +   +T+++                            M  +S+V     +    S   ++    NS F   +  HG+++DL   + SQ F       L+ L  ++ DN+ S  +   NYPS+ECLR  +  +VS +L +                                 S F    ++L  +SV+ + +   PS  L++W   ++PRY KK  +   N I+  ++        ++      ++   + + +LH++NE+H   I YNTFY+  +    ++  ++  WL+  +      FS  DYPF+FD  +K  ++ IEA+                  L+S  +   M   S     F I VRRDN+L DT+S L  A     KK  RV F  E+A+DEGGVMKE FLLV+  +LNP YG+F  YPESR+ WF++   + +N+  F  +G L GLAIYN++++DL FPL MF+KLL E   LDDL EL+P +G+SLQ LLDYD  D  D+F LNF V+++ +G      L+ DG +  VT  N+  YV+ YV+Y+  K+ E P+K F++GF     G  LK F+P ELQ L+VGSE  +W  LR++  Y G YW+ HQ II ++       + +EKKKFLR+LTGCDRVPI G S +KI IQP N  D++LPVAHTC NLLDLP+Y+ + IL  KL +AI+  EGF LV
Sbjct:   38 LNFTFITNVLLSKDTLMVSSATEELFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTLIQITCGYTHTVFLTIDGEVYSCGCNEFQQLGHGQSGGQLAKVVALEHYRIISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG-DDTGVKLVRALSDHKVVQVSLGVEHTLVLTDTARVFAFGSNLKGQLGLGYSSEQSVSIPQQILCLSGLPVRRIVAGGWHSFVLTVSGSLYAWGSNNYGQLGLSYFGSSPNDHQNELTLKCGSVGSTSVDDEQSKNRPFSPLDTSLSNVSIPTFVKTLRGCEVVYLACGETHTVALTRDGGVFTFGAGRYGQLGHNESTIGISVPRKITEFMGNVVTQIACGRFHTLALVPKTGRLFAFGQGTNAQLGMGDTKNRLLPC-PVKGHWVSSHKSSSNESTVGTDSSSSKPYIIRRIFSGGDHTYLLAQMYQAGETVDPDDLRNWNRSSLQSILTICPEIVEQLRNAHTALALPPPISRSISLSSSRPLTSSLSSTSNEPMTIVSKVESVFSSLGCLSASCLEEKEPNSHFKTDREEHGVDLDLACKLQSQIFHILPKRDLKRLINKLLDNVLSTSRL--NYPSIECLRGLMFLSVSDLLNMPRKPIMDEAVSDVNNIDITSEKNTNFEPYPVLSSGFSTPGLVLNAYSVAINRLDPAPSKILDRWFTKMQPRYLKKLVLNLNNLISYILDMEPASAYSQRKLKEESIRQALEFMKRLHRVNENHPNPISYNTFYLTSLKDKINIGSAFVNWLQECNSGGMRFFSFCDYPFVFDAASKAEMLNIEARLTMQQAMSQAQQSAIFQSLLSPFIGTRMYDGSTSSPYFTIIVRRDNILQDTLSNLTMANPADFKKLLRVKFENEEAVDEGGVMKEFFLLVMRDLLNPVYGMFRCYPESRMLWFSESTMESENV--FLMVGILCGLAIYNSIIVDLSFPLAMFRKLLGETPGLDDLKELDPIVGRSLQELLDYDNADLADVFCLNFTVTIDYFGMNKIIPLMEDGENIIVTQENKSLYVEKYVEYVFQKSCETPYKAFEKGFLQVCGGYSLKLFQPSELQSLVVGSEVVNWDELRQNTTYQGIYWDRHQVIIWFWDVLLYDFTIEEKKKFLRFLTGCDRVPIVGFSGVKITIQPNNSGDDFLPVAHTCANLLDLPQYSCKEILAKKLSLAIQQTEGFGLV 1228          

HSP 2 Score: 89.3521 bits (220), Expect = 4.804e-14
Identity = 66/199 (33.17%), Postives = 97/199 (48.74%), Query Frame = 2
Query:  494 SLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLP-IKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGI 1087
            SL   FI  V    D  +  +   E+F+WG+   GQL L  N        +  ++ NLP +  IT G   +  LT  G +YS G N + QLG   +    +  + ++H R   I+ V+ G  H AA++ +G +FTWG    GQLG     + +   +V  L   KV Q+  G+ HTL  +  T  V+AFG    GQLG+
Sbjct:   37 SLNFTFITNVLLSKDTLMVSSATEELFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTLIQITCGYTHTVFLTIDGEVYSCGCNEFQQLGHGQSGGQLAKVVALEHYR---IISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG--DDTGVKLVRALSDHKVVQVSLGVEHTLV-LTDTARVFAFGSNLKGQLGL 229          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Match: G4VNS7 (Putative hect E3 ubiquitin ligase OS=Schistosoma mansoni OX=6183 GN=Smp_142890 PE=4 SV=1)

HSP 1 Score: 718.768 bits (1854), Expect = 0.000e+0
Identity = 435/1173 (37.08%), Postives = 644/1173 (54.90%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDM-VSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGR---------------------------------------DLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFE-NKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQS--KISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPI---YTSIS---------------------------TMKSISEVXXXXXXXXXXXXXDIK----NSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEI---------------------------------SEFCK--VILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---FSLFDYPFLFDGITKTNLMKIEAK-----------------CLMSEGLPCFMAQSS-----FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQ-IIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +F++G+   GQL +D  +      P+ +D  +   + +I+CG+ HT+FL  +G++YSCG NEF++LGH  +  +  ++  L+ +++I  + G  HNA +T  GL+FTWG NS G+LGR+   D  +KLV++L+ H +VQV+ G +HTL LT  + +F++G+N  GQLGLG + +  VS PQQI  LS LP++ I AG   SFVLT SG LY+WGSNNYGQLG                                        D + S  S+P  VK LR   +VY++ G+ H  AL+ DGGVFT+G GRYGQLGHN      S+P  + + +G+ V+QI CG  HTLA +  TG ++AFG G   QLG+ DT        P+ GHWV    ++ +   +  ++++ + YI++R++ GG+H+ + A     G+ V PDDLR WN     +I  +  ++ E +   +T+++                            M  +S+V     +    S   ++    NS F   +  HG+++DL   + SQ F       L+ L  ++ DN+ S  +   NYPS+ECLR  +  +VS +L +                                 S F    ++L  +SV+ + +   PS  L++W   ++PRY KK  +   N I+  ++        ++      ++   + + +LH++NE+H   I YNTFY+  +    ++  ++  WL+  +      FS  DYPF+FD  +K  ++ IEA+                  L+S  +   M   S     F I VRRDN+L DT+S L  A     KK  RV F  E+A+DEGGVMKE FLLV+  +LNP YG+F  YPESR+ WF++   + +N+  F  +G L GLAIYN++++DL FPL MF+KLL E   LDDL EL+P +G+SLQ LLDYD  D  D+F LNF V+++ +G      L+ DG +  VT  N+  YV+ YV+Y+  K+ E P+K F++GF     G  LK F+P ELQ L+VGSE  +W  LR++  Y G YW+ HQ II ++       + +EKKKFLR+LTGCDRVPI G S +KI IQP N  D++LPVAHTC NLLDLP+Y+ + IL  KL +AI+  EGF LV
Sbjct:    9 LFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTLIQITCGYTHTVFLTIDGEVYSCGCNEFQQLGHGQSGGQLAKVVALEHYRIISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG-DDTGVKLVRALSDHKVVQVSLGVEHTLVLTDTARVFAFGSNLKGQLGLGYSSEQSVSIPQQILCLSGLPVRRIVAGGWHSFVLTVSGSLYAWGSNNYGQLGLSYFGSSPNDHQNELTLKCGSVGSTSVDDEQSKNRPFSPLDTSLSNVSIPTFVKTLRGCEVVYLACGETHTVALTRDGGVFTFGAGRYGQLGHNESTIGISVPRKITEFMGNVVTQIACGRFHTLALVPKTGRLFAFGQGTNAQLGMGDTKNRLLPC-PVKGHWVSSHKSSSNESTVGTDSSSSKPYIIRRIFSGGDHTYLLAQMYQAGETVDPDDLRNWNRSSLQSILTICPEIVEQLRNAHTALALPPPISRSISLSSSRPLTSSLSSTSNEPMTIVSKVESVFSSLGCLSASCLEEKEPNSHFKTDREEHGVDLDLACKLQSQIFHILPKRDLKRLINKLLDNVLSTSRL--NYPSIECLRGLMFLSVSDLLNMPRKPIMDEAVSDVNNIDITSEKNTNFEPYPVLSSGFSTPGLVLNAYSVAINRLDPAPSKILDRWFTKMQPRYLKKLVLNLNNLISYILDMEPASAYSQRKLKEESIRQALEFMKRLHRVNENHPNPISYNTFYLTSLKDKINIGSAFVNWLQECNSGGMRFFSFCDYPFVFDAASKAEMLNIEARLTMQQAMSQAQQSAIFQSLLSPFIGTRMYDGSTSSPYFTIIVRRDNILQDTLSNLTMANPADFKKLLRVKFENEEAVDEGGVMKEFFLLVMRDLLNPVYGMFRCYPESRMLWFSESTMESENV--FLMVGILCGLAIYNSIIVDLSFPLAMFRKLLGETPGLDDLKELDPIVGRSLQELLDYDNADLADVFCLNFTVTIDYFGMNKIIPLMEDGENIIVTQENKSLYVEKYVEYVFQKSCETPYKAFEKGFLQVCGGYSLKLFQPSELQSLVVGSEVVNWDELRQNTTYQGIYWDRHQVIIWFWDVLLYDFTIEEKKKFLRFLTGCDRVPIVGFSGVKITIQPNNSGDDFLPVAHTCANLLDLPQYSCKEILAKKLSLAIQQTEGFGLV 1175          

HSP 2 Score: 83.1889 bits (204), Expect = 3.794e-12
Identity = 60/179 (33.52%), Postives = 90/179 (50.28%), Query Frame = 2
Query:  554 TKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLP-IKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGI 1087
            +   E+F+WG+   GQL L  N        +  ++ NLP +  IT G   +  LT  G +YS G N + QLG   +    +  + ++H R   I+ V+ G  H AA++ +G +FTWG    GQLG     + +   +V  L   KV Q+  G+ HTL  +  T  V+AFG    GQLG+
Sbjct:    4 SATEELFAWGSCEEGQLTLDKNDAYQILIPKALDVRNLPTLIQITCGYTHTVFLTIDGEVYSCGCNEFQQLGHGQSGGQLAKVVALEHYR---IISVACGAYHNAAITYNGLLFTWGCNSNGQLGREG--DDTGVKLVRALSDHKVVQVSLGVEHTLV-LTDTARVFAFGSNLKGQLGL 176          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Match: A0A4S2LMJ3 (HECT domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006165 PE=4 SV=1)

HSP 1 Score: 690.649 bits (1781), Expect = 0.000e+0
Identity = 419/1153 (36.34%), Postives = 614/1153 (53.25%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDM-VSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDL------------TTSYES-------LPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENK-SIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPL-ECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVM-------------NVDVNEPIY-------------TSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISE--------------------------------------FCKVILIP--------FSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE---FSLFDYPFLFDGITKTNLMKIEAKCLMSE-------------------GLPCFMAQSSF-HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIX-XXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +F +GA    QLG   ++    S PQ I   S   I +++CG+ HTL L  +G++YSCG NEF +LG         +I  L+ H + D + G  HNA ++  G +FTWG NS G+LGR+   D S+K+++SL  H +VQV+ G +H+L LT  S +F +G+N  GQLGLG   D+ +  PQQ+  LS LPI+ I+AG   S VLT SG LY WG N YGQLG +              +S ES       +P  VK L+ Q  V+V  G++H   L+ +GGVFT+G  ++GQLGH       SIP  V DL+ +  +Q+ CG  HTL  + S G VYAFG G  GQLG  +T        P+ G W+     +NQS  S +   E    V RLY GG+H+           ++  +D R+W+     +I  +              + +  P+Y              S   M +   +  +  +    +   + ++ F   +  HG+++D   ++  Q F       L+ L  ++ D + +  +   NYPS+ECLR  ++ AVS +L                                            K+  +P        F+++ + +   PS  +++W   ++PRYFKK      N I   +N        ++ S    ++   + + +L++INE     I Y +FYIP + +  +++ S+  WLR         FS  DYPF+FD  TK  L+ +EA   M                     G P   + S F H+TVRRD L+ DT++ L  A    L+K  RV F GE+A+DEGGVMKE FLLV+  +L+P YG+F  YPESR+ WF++   + DN+  F  IG L GLAIYN++++DL FPL MF+KLL +K  LDDL+EL+P +G+SLQ LLDY+  D  + F L F + ++C+G     EL+ +G +  VT  N+  YV+ YVDY+ NK+ E P++ F+ GFH    G  LKFF+P+ELQ L+VGSE  +W  LR++  Y G YW++H +I  ++       S ++KK+FLR+LTGCDRVP+ G + ++I IQP+N  D YLPVAHTC NLLDLP Y+S+ +LR KL IAI++ EGF LV
Sbjct:    9 LFGWGACDDNQLGPHEQDSQQISSPQPITVPSRWTIARVACGYKHTLLLNADGEVYSCGGNEFGQLGRSDAPPDFRRITALENHTITDIACGAYHNAAISYTGRLFTWGCNSNGQLGREG-DDSSVKMIRSLAEHRVVQVSLGLEHSLVLTDTSRLFVFGSNIWGQLGLGFRSDLPIVIPQQLMCLSGLPIRCISAGGVHSAVLTISGTLYVWGGNKYGQLGLEPIEMVAVESVSGSRSSIESAPQHSVSVPTAVKSLKGQRAVFVDCGESHTVVLTEEGGVFTYGGNQFGQLGHGESSKSISIPRKVADLMDNPTTQVACGRMHTLVLVPSLGCVYAFGAGSEGQLGT-NTNTDSSRPMPVKGPWLRSGTSSNQSTNSPDVPLE----VARLYAGGDHAYALTRKSTTKSQIVVEDFRVWDPMSSRSIATVCPQALDHLRDALTALPLPAPMYRTSSTCSESSDSTNSQHVMFASLRLETAFSSLGCLAATCLADNHFSTGRDQHGVDLDAARDLQQQLFRQLQPKNLRRLIEKLMDGVLNVAR--PNYPSIECLRGLMVLAVSDLLNTPRAPDRPNSHDSSHSDISAPIDKHSLSDSDWNESGEAGPFLVKLAGLPNPGMVLHGFTLAINQLEPAPSKIIDRWFARVQPRYFKKLVTNLNNHIVYILNMQPATADYERRSKEEGVRSSLELMKRLYRINESRQPPISYVSFYIPVVREKVNIDSSFLSWLRERESGGMHFFSFCDYPFIFDAPTKARLLSLEATLSMQNAVNQAERNTLIQSVMSPLLGYPVLTSTSPFFHVTVRRDFLIQDTLTYLTVANPSELRKVLRVQFAGEEAVDEGGVMKEFFLLVMRDLLSPIYGMFRCYPESRMLWFSEFTMESDNV--FLLIGILCGLAIYNSIIVDLAFPLAMFRKLLGDKPVLDDLMELDPVVGRSLQQLLDYEGQDVAETFCLTFSLDIDCFGETRHIELVENGSNIEVTHENKSLYVEKYVDYVFNKSCEAPYRAFERGFHQVCAGHALKFFRPMELQSLVVGSEVVNWNELRQNTSYQGVYWDHHPVIEWFWEVLLVEFSVEDKKRFLRFLTGCDRVPLFGFTSLRITIQPMNCGDEYLPVAHTCANLLDLPLYSSKDVLRLKLSIAIQHTEGFGLV 1151          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Match: A0A4Z2CNU8 (Putative E3 ubiquitin-protein ligase HERC4 OS=Schistosoma japonicum OX=6182 GN=EWB00_008797 PE=4 SV=1)

HSP 1 Score: 685.641 bits (1768), Expect = 0.000e+0
Identity = 429/1176 (36.48%), Postives = 622/1176 (52.89%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSY--PQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDM-VSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGR------------------------------------DLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFE-NKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLE--CNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWN--------------------------------------WKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILE----------ISEFCK-------------------------VILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLR--NVSKIE-FSLFDYPFLFDGITKTNLMKIEAKCLMSE-------------------GLPCFMAQSS---FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQ-IIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +F +G+   GQL  D  N D ++   P+ ++  +  +  +ISCG+ HT+FL  +G++YSCG NEF++LGH  +  +  ++  L+ +++I  + G  HNA VT  GL+FTWG NS G+LGR+   D ++KLV++L+ H +VQV+ G +HTL LT  + +F++G+N  GQLGLG + +  V  PQQI  LS LPI+ ITAG   SFVLT SG LY+WGSN YGQLG                                     D   S  S+P  VK LR   +VY++ G+ H  AL+ DGGVFT+G GRYGQLGHN      ++P  +++  G+ V+QI CG  HTLA +  +G ++AFG G  GQLG+ DT        P+ G WV      N QS +  +    + YI++R++ GG+H+ + A     G+KV  DDLR WN                                         P   T  N   NEP+        + S +   S +CL        N  F   +  HG+++DL + + S          L+ L  ++ DN+ +   +N  YPS+ECLR  +  AVS ++           I+E  K                         ++L  +SV+ + +   PS  L++W   ++PRY KK  +   N I+  ++     +  ++      ++   + + +LH++NE H   I YN FY+P +    ++  ++  WL+  N   I  FS FDYPF+FD  +K  L+ +EA+  M +                   G P +   +S   F I VRR+N+L DT+S L  A     KK  +V F  E+A+DEGGVMKE FLLV+  +LNP YG+F  YPES + WFN+   + +N+  F   G L GLAIYN++++DL FP  MF                 P +G+SLQ LLDYD +D  D+F LNF V+++ +G      L+ +G +  VT  N+  YV+ YVDY+ NK+ E  +K F++GF     G  LK F P ELQ L+VGSE  +W  LR++  Y G YW+ HQ II ++       + +EKKKFLR+LTGCDRVP+ G S +KI IQP N  D++LPVAHTC NLLDLP+Y+S+ IL  KL +AI+  EGF LV
Sbjct:    8 LFVWGSCEDGQLTSD--NTDTFNVLTPKALNVQNLPEFVQISCGYTHTVFLTIDGEVYSCGCNEFQQLGHRQSGGRLGKVAALEQYRIISVACGAYHNAAVTYSGLLFTWGCNSNGQLGREG-DDTAVKLVRALSDHRVVQVSLGVEHTLVLTDTARVFAFGSNLKGQLGLGFSSEQPVPIPQQILCLSGLPIRRITAGGWHSFVLTVSGSLYAWGSNKYGQLGLSYFGSSPSDHHEFATKYGSSFSVDDEQSKSRSYSPIDTNRSNVSIPTYVKTLRGCEVVYLACGEAHTVALTRDGGVFTFGAGRYGQLGHNELTIGIAVPRKIIEFTGNVVTQIACGRFHTLALIPKSGRLFAFGQGTNGQLGMGDTTNRLLPC-PVKGQWVSCHEFSNRQSVVGNDLQFVKPYIIRRIFSGGDHAYLLAKMYQTGEKVEADDLRNWNRLSLQSIVTICPEIVQQLRNALTALPLPPAVSRSISLSSSRPLTTTSFNPTSNEPMSIVTQVESAFSSLGCLSASCLEEKE---PNCHFKTGREEHGVDLDLAYKLQSSILHVLPQRDLKRLINKLMDNVLTTSHHN--YPSIECLRGLMFLAVSDLMNMPLKPVTDDTITEIKKTDVHLEIIDAVNFYPVLSAGFSTPSLVLNAYSVAVNRLDSAPSKILDRWFTKMQPRYLKKLVLNLNNLISYILDMQPASSYSQRKLKEEGIRQALEFMKRLHRVNESHPNPIPYNRFYLPSLKDKINIGSAFVNWLQECNSGGIRFFSFFDYPFVFDAASKAELLNVEARLSMQQAMTQAQQSAILQTFISPFIGGPVYSGSTSAPYFTIVVRRNNILQDTLSHLTMANPADFKKLLKVQFENEEAVDEGGVMKEFFLLVMRDLLNPVYGMFRCYPESHMLWFNESTMESENV--FLMAGILCGLAIYNSIIVDLSFPQAMFY----------------PIVGRSLQQLLDYDGDDLADVFYLNFSVTIDYFGVNKVIPLMENGENIVVTQENKNLYVEKYVDYVFNKSCETSYKAFEKGFLQVCNGYSLKLFHPFELQALVVGSEVINWDELRQNTTYQGVYWDRHQVIIWFWEVLLHDFTVEEKKKFLRFLTGCDRVPVVGFSGVKITIQPNNSGDDFLPVAHTCANLLDLPQYSSKEILSKKLSLAIQQTEGFGLV 1156          

HSP 2 Score: 83.5741 bits (205), Expect = 2.322e-12
Identity = 72/251 (28.69%), Postives = 122/251 (48.61%), Query Frame = 2
Query:   80 IIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWG-----KNSFGELGRDKLSDFSIKL-VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTP-SGFLYSWGSNNYGQLGRDLTTSYESLPLMVK 811
            +++     +F+FG+   GQLG+   ++     PQ+I  +S   I +I+ G  H+  L  +G LY+ G+N++ +LG       P+                 DH+   T  G  F+         S+  +  ++ S+ SI   V++L G  +V +ACG  HT+ALT++  +F++GA   GQLG  +    ++ P++I   +   +  I  G   +  L P SG L+++G    GQLG   TT+   LP  VK
Sbjct:  154 LVLTDTARVFAFGSNLKGQLGLGFSSEQPVPIPQQILCLSGLPIRRITAGGWHSFVLTVSGSLYAWGSNKYGQLGLSYFGSSPS-----------------DHHEFATKYGSSFSVDDEQSKSRSYSPIDTNR-SNVSIPTYVKTLRGCEVVYLACGEAHTVALTRDGGVFTFGAGRYGQLGHNELTIGIAVPRKIIEFTGNVVTQIACGRFHTLALIPKSGRLFAFGQGTNGQLGMGDTTN-RLLPCPVK 385          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:NCBI gene;Acc:103028096])

HSP 1 Score: 646.351 bits (1666), Expect = 0.000e+0
Identity = 383/1071 (35.76%), Postives = 581/1071 (54.25%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYP-DDLRLWNWKHPTNITVMNVDVNEPIYT------SISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCK--------LHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIE-----FSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHIT--------------VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P+K    +   +  + CG  HT+FLL +G +Y+CG N+  +LGH+  + KP Q+  LDA  ++  S G  H   + + G VF WG+ S G+LG   + D  +++   ++SL+   IVQV CG+ H+LAL++  +IFSWG N  GQLGLG     V TPQ +++L  +P   I+AG   SF LT SG ++ WG N +GQLG +   S    P ++K LR Q +VY+  G++H AAL+ +GGVFT+G G YGQLGHN   ++  P  V +L+G+ V+QI CG  HT+A++ S+G + +FGLG  GQLG   T     +  P+ G W          I  E  AE+ Y VKR+Y GG+ S    +   C +   P +DLR+ N     ++  +N D+ +          S      I  V  S+     S         +  S    G++ ++   + S+   +      Q +A  ++ N+   +  + + P +E LR +L      +         + IPF+ + + +       L  W   ++P  F+    ++ + +   +         +K         +F C           LH +NE   +II Y+ FYI ++ ++ D+   Y  WL+    ++      SL  Y F+ D   KT L++I+A   M   +      SS +++              VRR+N++GDT+  L ++     KK  +V F+GE+A+D GGV KE FLL++ ++L+P YG+F  Y ESRL WF    F++ +  F+ IG + GLAIYN  +++L+FP+ ++KKLL     LDDL EL P +G+SLQ LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +V+ YVDYI N +V Q F  F  GFH    G  L+ F+P ELQ +++G+ +YDW  L +S EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  + + IQP    ++YLPVAHTC+NLLDLPKY S  IL++KL  AIE+N+GF L 
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVVEPRKCSFFNGKLVWDVGCGRRHTVFLLGDGTVYTCGCNDLGQLGHEKTRKKPEQVVALDAQNIVAVSCGESHTLALNDKGQVFAWGQASEGQLGLANMED-CVRVPRNIKSLSEVHIVQVTCGYRHSLALSRRGQIFSWGQNKYGQLGLGKEGPSVLTPQLVQSLLGIPFAQISAGGAHSFGLTLSGAVFGWGRNKFGQLGLN-DNSDRCAPCLLKTLRSQRVVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNTTNHEINPRKVFELMGNVVTQISCGRQHTMAFIPSSGKIDSFGLGGNGQLGTRSTCNR-KSPAPVKGQWRAY----NDPIPMEEEAEEFYCVKRIYAGGDQSF---AYCQCPQNTSPPEDLRVQNSTQ--HVLTLNSDLIQKWLDHGHGRLSPEITDEIDLVFSSASCLNGSFLSTSHPGHYSTSGKCSGVDENMARVLFSRLIQTDYPHISQQVAASLEKNLIPNL--SSSPPDIEALRLYLTLPQCPLFSNPNTYITLAIPFAKAVTSLKPAALKVLGNWWSRIEPAVFQGMVELYKDVVVYLLR-------MQKVGIPPSEHRLFTCFLSTCLRFLEILHSVNERSGQIIQYDKFYIHELEELVDIRQEYVSWLQQQFSVQPIDSQVSLCRYSFILDAQAKTTLLQIDAVFQMQLAVDQANRLSSMYLSGAAMESVNPCLILIVRRENVVGDTMEVLRKSKNVDYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFADKTFEE-VDLFHLIGVICGLAIYNLTIVELNFPVALYKKLLKRTPTLDDLKELMPDVGRSLQQLLDYTEDDVEETFCLNFTITVENFGATEVLELVPNGMDINVNNHNRQDFVNAYVDYIFNTSVAQLFNAFHAGFHKVCGGNVLELFQPNELQAMVIGNTNYDWKELEQSAEYKGEYWAGHPTIKLFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLALVIQPTGGGEHYLPVAHTCFNLLDLPKYNSRQILQEKLLKAIEHNQGFNLA 1049          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:NCBI gene;Acc:103028096])

HSP 1 Score: 632.484 bits (1630), Expect = 0.000e+0
Identity = 380/1075 (35.35%), Postives = 576/1075 (53.58%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHW------VPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYT------SISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCK--------LHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKI----EFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHIT--------------VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P+K    +   +  + CG  HT+FLL +G +Y+CG N+  +LGH+  + KP Q+  LDA  ++  S G  H   + + G VF WG+ S G+LG   + D  +++   ++SL+   IVQV CG+ H+LAL++  +IFSWG N  GQLGLG     V TPQ +++L  +P   I+AG   SF LT SG ++ WG N +GQLG +   S    P ++K LR Q +VY+  G++H AAL+ +GGVFT+G G YGQLGHN   ++  P  V +L+G+ V+QI CG  HT+A++ S+G + +FGLG  GQLG   T     +  P+ G W      +P+E             E  Y   R+ G      IT    DC     P+DLR+ N     ++  +N D+ +          S      I  V  S+     S         +  S    G++ ++   + S+   +      Q +A  ++ N+   +  + + P +E LR +L      +         + IPF+ + + +       L  W   ++P  F+    ++ + +   +         +K         +F C           LH +NE   +II Y+ FYI ++ ++ D+   Y  WL+    +    + SL  Y F+ D   KT L++I+A   M   +      SS +++              VRR+N++GDT+  L ++     KK  +V F+GE+A+D GGV KE FLL++ ++L+P YG+F  Y ESRL WF    F++ +  F+ IG + GLAIYN  +++L+FP+ ++KKLL     LDDL EL P +G+SLQ LLDY ++D E+ F LNF +++E +G     EL+ +G D  V   NRQ +V+ YVDYI N +V Q F  F  GFH    G  L+ F+P ELQ +++G+ +YDW  L +S EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  + + IQP    ++YLPVAHTC+NLLDLPKY S  IL++KL  AIE+N+GF L 
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVVEPRKCSFFNGKLVWDVGCGRRHTVFLLGDGTVYTCGCNDLGQLGHEKTRKKPEQVVALDAQNIVAVSCGESHTLALNDKGQVFAWGQASEGQLGLANMED-CVRVPRNIKSLSEVHIVQVTCGYRHSLALSRRGQIFSWGQNKYGQLGLGKEGPSVLTPQLVQSLLGIPFAQISAGGAHSFGLTLSGAVFGWGRNKFGQLGLN-DNSDRCAPCLLKTLRSQRVVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNTTNHEINPRKVFELMGNVVTQISCGRQHTMAFIPSSGKIDSFGLGGNGQLGTRSTCNR-KSPAPVKGQWRAYNDPIPME-------------EGQYTQHRIMG------IT----DCQNTSPPEDLRVQNSTQ--HVLTLNSDLIQKWLDHGHGRLSPEITDEIDLVFSSASCLNGSFLSTSHPGHYSTSGKCSGVDENMARVLFSRLIQTDYPHISQQVAASLEKNLIPNL--SSSPPDIEALRLYLTLPQCPLFSNPNTYITLAIPFAKAVTSLKPAALKVLGNWWSRIEPAVFQGMVELYKDVVVYLLR-------MQKVGIPPSEHRLFTCFLSTCLRFLEILHSVNERSGQIIQYDKFYIHELEELVDIRQEYVSWLQQQFSVPIDSQVSLCRYSFILDAQAKTTLLQIDAVFQMQLAVDQANRLSSMYLSGAAMESVNPCLILIVRRENVVGDTMEVLRKSKNVDYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFADKTFEE-VDLFHLIGVICGLAIYNLTIVELNFPVALYKKLLKRTPTLDDLKELMPDVGRSLQQLLDYTEDDVEETFCLNFTITVENFGATEVLELVPNGMDINVNNHNRQDFVNAYVDYIFNTSVAQLFNAFHAGFHKVCGGNVLELFQPNELQAMVIGNTNYDWKELEQSAEYKGEYWAGHPTIKLFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLALVIQPTGGGEHYLPVAHTCFNLLDLPKYNSRQILQEKLLKAIEHNQGFNLA 1037          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:103047299])

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 363/1071 (33.89%), Postives = 582/1071 (54.34%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSK---ISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMN--------VDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF---------SLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G++++GQLG+    +   + P+     S   +++++C   H+LFLL +G +YSCG+N   +LGH+    KP  +  LDA K+   + G  H+  V   G VF WG    G+LG   + +     +L++ L  H I QV CG+ H +AL K+ ++F+WG N+ GQLGLG       +PQ +K+L  +P+  I+AG   SF L+ SG ++ WG N+ GQLG +      ++P  +K LR Q +VY+S G  H AAL+ DGG+FT+G+G  GQLGH++  N+ +P  V++L+G++VSQI CG +HTLA++ STG VYAFG    GQLG+ +               +PL   N       S +T+    YI  R++ GG+HS +  S     +K  P+D R+ N     +I+++N        V + +   +SI+    +  +L S+    +S      +  F  +    G++++    +         S  L+      +  +  Q+  +   P +E +R +LI +    L  S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G +           I        L KLH++N+  + +  YN FYIP I  + D++  Y  W  + ++I+          +L  YPF+ +   KT +++ +A+  M                 L   +AQ+ F +  VRR++L+ D + +L       LKK  +V F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ES L WF+   F ++   FN IG + GLAIYN+ ++DLHFPLV++KKLL+   +LDDL EL+PT G+SLQ LLDY+ +D E+ F LNF ++ E YG     EL+  G +  V  SNR+ +V  Y+ Y+ + +V++ +  F  GF     G+ L  F+P EL  ++VG+ SY+W  L K+  Y GE+  +H  +  FW  F     ++KK+FL +LTG DR+PI+GM+ ++I +Q  +  ++YLPVAHTCYNLLD+P Y ++  L  +L  AIE  EGF+LV
Sbjct:    1 MLCWGSSAWGQLGLG-DAEPVVAEPRSCRMFSGRGLKEVACRGQHSLFLLHDGSVYSCGSNSHGQLGHEKPGNKPELVVALDAQKIAGVACGDAHSLAVNEQGQVFAWGTGEKGQLGLGTVEEAVRVPRLIKKLCEHRISQVMCGNQHCIALAKDGQLFTWGQNSSGQLGLGKGEPSSLSPQPLKSLCGIPLAQISAGGDHSFALSLSGAVFGWGRNSAGQLGLN-DEQDRAVPCHIKFLRSQKVVYISCGDEHTAALTKDGGLFTFGNGSRGQLGHDSTNNEPLPRRVLELMGTEVSQIVCGKHHTLAFVPSTGLVYAFGCNAHGQLGLANR----------GNARIPLPVRNIQPPYLSSSQTSDTDHYIPSRIHCGGDHSFLLLSR----EKNCPEDFRIINTS--KSISLINDESLNSWRVRLLDGADSSITN--DVILLLSSTACWNASFLDQSDDGHFKTNPKVPGIDLNSVRLLFETLMKPSYSRLLEQTTKSFESLLIPQLPCSP--PDVEAMRIYLILSECPALHDSKNYISLTIPLAMAILRLDANPSKVLDNWWSLVDCEVFSRLVEMYKSIVVFLLTGGKALLIPVFLESYISA--TLRLLEKLHKVNQKAHHV-EYNRFYIPDITSLVDIQEDYLKWFLSKAEIKMRSPPVQNSVTLCAYPFILNAQAKTTMLQTDAELQMQMAVSGANLHNVFMLLTLEPLLAQNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLDPVYGMFTHYSESNLLWFSDKCFVEH-NWFNLIGIVCGLAIYNSTVVDLHFPLVLYKKLLDVSPSLDDLKELSPTEGRSLQQLLDYEGDDIEETFCLNFAITREHYGMTEVKELVPGGENITVDRSNREEFVQAYLRYVFSDSVQELYSAFSGGFLKVCGGRILSLFQPSELMAMVVGNSSYNWEELEKNAVYKGEFSASHPTVRMFWEVFHDFPLEKKKQFLLFLTGSDRIPIHGMASLRIVLQSTSAAEHYLPVAHTCYNLLDMPCYKTKETLHLRLTRAIEQYEGFSLV 1045          

HSP 2 Score: 148.673 bits (374), Expect = 8.554e-36
Identity = 106/327 (32.42%), Postives = 172/327 (52.60%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGID-PRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG----HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGE--LGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGG-VFTWGHGRYGQLGHNNFENKSIPCIVMDL----LGSK---------VSQIECGMNHT 1018
            S++S G+ S+GQLG + P NK     P+ +  + +  I  ++CG  H+L + + G++++ G  E  +LG     +  +V P  I+ L  H++     G  H   +   G +FTWG+NS G+  LG+ + S  S + ++SL G  + Q++ G DH+ AL+ +  +F WG N+ GQLGL D  D  + P  IK L +  +  I+ GD+ +  LT  G L+++G+ + GQLG D +T+ E LP  V  L    +  +  G++H  A     G V+ +G   +GQLG  N  N  IP  V ++    L S           S+I CG +H+
Sbjct:   53 SVYSCGSNSHGQLGHEKPGNK-----PELVVALDAQKIAGVACGDAHSLAVNEQGQVFAWGTGEKGQLGLGTVEEAVRV-PRLIKKLCEHRISQVMCGNQHCIALAKDGQLFTWGQNSSGQLGLGKGEPSSLSPQPLKSLCGIPLAQISAGGDHSFALSLSGAVFGWGRNSAGQLGLNDEQDR-AVPCHIKFLRSQKVVYISCGDEHTAALTKDGGLFTFGNGSRGQLGHD-STNNEPLPRRVLELMGTEVSQIVCGKHHTLAFVPSTGLVYAFGCNAHGQLGLANRGNARIPLPVRNIQPPYLSSSQTSDTDHYIPSRIHCGGDHS 371          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:103047299])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 367/1110 (33.06%), Postives = 587/1110 (52.88%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVP------------------------LECNNQSKIS-GETTAEQM-----------------YIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMN--------VDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF---------SLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G++++GQLG+    +   + P+     S   +++++C   H+LFLL +G +YSCG+N   +LGH+    KP  +  LDA K+   + G  H+  V   G VF WG    G+LG   + +     +L++ L  H I QV CG+ H +AL K+ ++F+WG N+ GQLGLG       +PQ +K+L  +P+  I+AG   SF L+ SG ++ WG N+ GQLG +      ++P  +K LR Q +VY+S G  H AAL+ DGG+FT+G+G  GQLGH++  N+ +P  V++L+G++VSQI CG +HTLA++ STG VYAFG    GQLG+ +         P+     P                        L C ++S       +AEQM                 YI  R++ GG+HS +  S     +K  P+D R+ N     +I+++N        V + +   +SI+    +  +L S+    +S      +  F  +    G++++    +         S  L+      +  +  Q+  +   P +E +R +LI +    L  S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G +           I        L KLH++N+  + +  YN FYIP I  + D++  Y  W  + ++I+          +L  YPF+ +   KT +++ +A+  M                 L   +AQ+ F +  VRR++L+ D + +L       LKK  +V F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ES L WF+   F ++   FN IG + GLAIYN+ ++DLHFPLV++KKLL+   +LDDL EL+PT G+SLQ LLDY+ +D E+ F LNF ++ E YG     EL+  G +  V  SNR+ +V  Y+ Y+ + +V++ +  F  GF     G+ L  F+P EL  ++VG+ SY+W  L K+  Y GE+  +H  +  FW  F     ++KK+FL +LTG DR+PI+GM+ ++I +Q  +  ++YLPVAHTCYNLLD+P Y ++  L  +L  AIE  EGF+LV
Sbjct:    1 MLCWGSSAWGQLGLG-DAEPVVAEPRSCRMFSGRGLKEVACRGQHSLFLLHDGSVYSCGSNSHGQLGHEKPGNKPELVVALDAQKIAGVACGDAHSLAVNEQGQVFAWGTGEKGQLGLGTVEEAVRVPRLIKKLCEHRISQVMCGNQHCIALAKDGQLFTWGQNSSGQLGLGKGEPSSLSPQPLKSLCGIPLAQISAGGDHSFALSLSGAVFGWGRNSAGQLGLN-DEQDRAVPCHIKFLRSQKVVYISCGDEHTAALTKDGGLFTFGNGSRGQLGHDSTNNEPLPRRVLELMGTEVSQIVCGKHHTLAFVPSTGLVYAFGCNAHGQLGLANRGN-ARIPLPVRNIQPPYLSSSQTSDRKSRPEDRSSIIRRILACFSRSSARVSPHSAEQMAAIESGDLGNSDSDTDHYIPSRIHCGGDHSFLLLSR----EKNCPEDFRIINTS--KSISLINDESLNSWRVRLLDGADSSITN--DVILLLSSTACWNASFLDQSDDGHFKTNPKVPGIDLNSVRLLFETLMKPSYSRLLEQTTKSFESLLIPQLPCSP--PDVEAMRIYLILSECPALHDSKNYISLTIPLAMAILRLDANPSKVLDNWWSLVDCEVFSRLVEMYKSIVVFLLTGGKALLIPVFLESYISA--TLRLLEKLHKVNQKAHHV-EYNRFYIPDITSLVDIQEDYLKWFLSKAEIKMRSPPVQNSVTLCAYPFILNAQAKTTMLQTDAELQMQMAVSGANLHNVFMLLTLEPLLAQNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLDPVYGMFTHYSESNLLWFSDKCFVEH-NWFNLIGIVCGLAIYNSTVVDLHFPLVLYKKLLDVSPSLDDLKELSPTEGRSLQQLLDYEGDDIEETFCLNFAITREHYGMTEVKELVPGGENITVDRSNREEFVQAYLRYVFSDSVQELYSAFSGGFLKVCGGRILSLFQPSELMAMVVGNSSYNWEELEKNAVYKGEFSASHPTVRMFWEVFHDFPLEKKKQFLLFLTGSDRIPIHGMASLRIVLQSTSAAEHYLPVAHTCYNLLDMPCYKTKETLHLRLTRAIEQYEGFSLV 1093          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:103047299])

HSP 1 Score: 322.013 bits (824), Expect = 2.873e-93
Identity = 199/555 (35.86%), Postives = 311/555 (56.04%), Query Frame = 2
Query: 1610 PSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWL--------RNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEG--------------LPCFMAQSSFHIT-VRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            P +E +R +LI +    L  S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G +           I        L KLH++N+  + +  YN FYIP I  + D++  Y  W          N++ +  +L  YPF+ +   KT +++ +A+  M                 L   +AQ+ F +  VRR++L+ D + +L       LKK  +V F GE+A+D GGV KE FLL++ ++L+P YG+F  Y ES L WF+   F ++   FN IG + GLAIYN+ ++DLHFPLV++KKLL+   +LDDL EL+PT G+SLQ LLDY+ +D E+ F LNF ++ E YG     EL+  G +  V  SNR+ +V  Y+ Y+ + +V++ +  F  GF     G+ L  F+P EL  ++VG+ SY+W  L K+  Y GE+  +H  +  FW  F     ++KK+FL +LTG DR+PI+GM+ ++I +Q  +  ++YLPVAHTCYNLLD+P Y ++  L  +L  AIE  EGF+LV
Sbjct:  431 PDVEAMRIYLILSECPALHDSKNYISLTIPLAMAILRLDANPSKVLDNWWSLVDCEVFSRLVEMYKSIVVFLLTGGKALLIPVFLESYISA--TLRLLEKLHKVNQKAHHV-EYNRFYIPDITSLVDIQEDYLKWFLTKLFRLCPNINSV--TLCAYPFILNAQAKTTMLQTDAELQMQMAVSGANLHNVFMLLTLEPLLAQNPFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLDPVYGMFTHYSESNLLWFSDKCFVEH-NWFNLIGIVCGLAIYNSTVVDLHFPLVLYKKLLDVSPSLDDLKELSPTEGRSLQQLLDYEGDDIEETFCLNFAITREHYGMTEVKELVPGGENITVDRSNREEFVQAYLRYVFSDSVQELYSAFSGGFLKVCGGRILSLFQPSELMAMVVGNSSYNWEELEKNAVYKGEFSASHPTVRMFWEVFHDFPLEKKKQFLLFLTGSDRIPIHGMASLRIVLQSTSAAEHYLPVAHTCYNLLDMPCYKTKETLHLRLTRAIEQYEGFSLV 979          

HSP 2 Score: 261.922 bits (668), Expect = 2.418e-72
Identity = 133/332 (40.06%), Postives = 205/332 (61.75%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS--IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICD 1093
            +  +G++++GQLG+    +   + P+     S   +++++C   H+LFLL +G +YSCG+N   +LGH+    KP  +  LDA K+   + G  H+  V   G VF WG    G+LG   + +     +L++ L  H I QV CG+ H +AL K+ ++F+WG N+ GQLGLG       +PQ +K+L  +P+  I+AG   SF L+ SG ++ WG N+ GQLG +      ++P  +K LR Q +VY+S G  H AAL+ DGG+FT+G+G  GQLGH++  N+ +P  V++L+G++VSQI CG +HTLA++ STG VYAFG    GQLG+ +
Sbjct:    1 MLCWGSSAWGQLGLG-DAEPVVAEPRSCRMFSGRGLKEVACRGQHSLFLLHDGSVYSCGSNSHGQLGHEKPGNKPELVVALDAQKIAGVACGDAHSLAVNEQGQVFAWGTGEKGQLGLGTVEEAVRVPRLIKKLCEHRISQVMCGNQHCIALAKDGQLFTWGQNSSGQLGLGKGEPSSLSPQPLKSLCGIPLAQISAGGDHSFALSLSGAVFGWGRNSAGQLGLN-DEQDRAVPCHIKFLRSQKVVYISCGDEHTAALTKDGGLFTFGNGSRGQLGHDSTNNEPLPRRVLELMGTEVSQIVCGKHHTLAFVPSTGLVYAFGCNAHGQLGLAN 330          

HSP 3 Score: 147.517 bits (371), Expect = 1.741e-35
Identity = 102/322 (31.68%), Postives = 170/322 (52.80%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGID-PRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLG----HDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGE--LGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGG-VFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTG 1042
            S++S G+ S+GQLG + P NK     P+ +  + +  I  ++CG  H+L + + G++++ G  E  +LG     +  +V P  I+ L  H++     G  H   +   G +FTWG+NS G+  LG+ + S  S + ++SL G  + Q++ G DH+ AL+ +  +F WG N+ GQLGL D  D  + P  IK L +  +  I+ GD+ +  LT  G L+++G+ + GQLG D +T+ E LP  V  L    +  +  G++H  A     G V+ +G   +GQLG  N  N  IP  V ++    +S  +   +  +  + ST 
Sbjct:   53 SVYSCGSNSHGQLGHEKPGNK-----PELVVALDAQKIAGVACGDAHSLAVNEQGQVFAWGTGEKGQLGLGTVEEAVRV-PRLIKKLCEHRISQVMCGNQHCIALAKDGQLFTWGQNSSGQLGLGKGEPSSLSPQPLKSLCGIPLAQISAGGDHSFALSLSGAVFGWGRNSAGQLGLNDEQDR-AVPCHIKFLRSQKVVYISCGDEHTAALTKDGGLFTFGNGSRGQLGHD-STNNEPLPRRVLELMGTEVSQIVCGKHHTLAFVPSTGLVYAFGCNAHGQLGLANRGNARIPLPVRNIQPPYLSSSQTSGHDVILLLSSTA 366          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:ZFIN;Acc:ZDB-GENE-070801-1])

HSP 1 Score: 489.189 bits (1258), Expect = 1.170e-157
Identity = 306/843 (36.30%), Postives = 454/843 (53.86%), Query Frame = 2
Query:  797 PLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKP--INGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNH--------GLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIE--MKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN-------------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLM-------------SEGLPCFMAQSSFHITVRRDNLLGDTISQLHR-ATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDD-NLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            P ++K LR Q +VY+  G++H A L+ +GGVFT+G G YGQLGHN+  ++  P  V +L+GS V+QI CG  HTLA++ S+G +Y+FGLG  GQLG   T    +   P  + G WVP    +          E+  IVKR++ GG+ S   A        V PDD RL    H   + V++  + E  + S+ + +  S+V+       SS    I  S        H        GL+++ T    ++   S  +  LQ +A  ++  +  Q+  +   P +E +R +L+     ++        + I F+++ + +  TP+  L  W   L P +F K   ++  A+   +              I +  ++     L  LH+ N     +I Y+ FYI +I  + D+   Y  W++              + ++  +L  +PF+FD   KT L++ +A   M             S  +P         + VRRDN++GDT+  L + A     KK  +V F GEDA+D GGV KE FLL++  +L+P YGLF+ Y ESRL WF++  F+D NL  FN IG + GLAIYN+ ++DL+FPL ++KKLL  +  L+DL EL P +G+SLQ LLDY  +D E+ F LNF V+ E +G     EL+  G D  V  +NRQ +V+ YVDYI NK+V+Q F+ F  GFH    GK L+ F+P EL  +++G+  YDW  L K+ EY GEYW  H  I  FW  F  L  + KKKFL +LTG DR+PI GM  +KI IQP    + +LPVAHTC+NLLDLPK++ ++ LR+KL  +I + +GF+L 
Sbjct:    5 PALLKSLRTQKVVYICCGEDHTAILTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGST---SNRKSPFTVQGAWVP----HNGPCPSNVEKEECCIVKRIFAGGDQSF--AHYFPPEDSVEPDDFRLAE-PH-MQVCVLSGPLLEK-WASLPSGRLPSDVVNEIDMIFSSPSC-INGSFLAYGADEHYRTSGKVSGLDMNATRLAFNKLLQSPCTQVLQQMAASLEKTLIPQL--STAPPDVEAMRLYLVLPEFPLMHDERNFSTLAISFAMAITKLGPTPAKVLENWWSVLTPPFFLKLVELY-KAVVVFLLKLHKMGVPPAEEPIFQASLRSALVVLQILHRAN-TRTSVIQYDKFYIGEICDLVDIRRDYIAWIQQQAYRVDVNSAMAELKEVPVTLCSFPFVFDAQAKTTLLQTDAILQMQVAVDEATRRNFSSMFMPIDPENPCLVLMVRRDNIVGDTLEMLRKQAKNLDFKKPLKVIFYGEDAVDAGGVRKEFFLLIMKDLLDPKYGLFKYYEESRLIWFSQQTFEDSNL--FNLIGLICGLAIYNSTIVDLNFPLALYKKLLKVEPTLEDLKELMPDVGRSLQQLLDYPDDDVEETFCLNFTVAFENFGAMEVKELVPGGSDMVVNNANRQDFVNAYVDYIFNKSVQQLFEAFHTGFHKVCGGKVLQLFQPSELMAMVIGNTDYDWAELEKNTEYKGEYWAGHPTIKSFWEVFHELDLELKKKFLLFLTGSDRIPILGMKSLKIVIQPTGGGEQFLPVAHTCFNLLDLPKFSGKAQLREKLLQSITHYQGFSLA 828          

HSP 2 Score: 68.9366 bits (167), Expect = 5.386e-12
Identity = 37/104 (35.58%), Postives = 57/104 (54.81%), Query Frame = 2
Query:  314 NKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLS-DFSIKLVQSLTGHFIVQVACGHDHTLALTKNS-EIFSWGANTCGQLGLGDN 619
            +K  P  ++ L   K++    G DH A++T  G VFT+G   +G+LG +  + + + + V  L G  + Q+ACG  HTLA   +S  I+S+G    GQLG G  
Sbjct:    1 DKCYPALLKSLRTQKVVYICCGEDHTAILTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGST 104          

HSP 3 Score: 60.077 bits (144), Expect = 2.472e-9
Identity = 38/110 (34.55%), Postives = 58/110 (52.73%), Query Frame = 2
Query:  485 LVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTP-SGFLYSWGSNNYGQLGRDLTTSYESLPLMVK 811
            L++SL    +V + CG DHT  LTK   +F++GA   GQLG       V+ P+++  L    +  I  G + +    P SG +YS+G    GQLG   T++ +S P  V+
Sbjct:    7 LLKSLRTQKVVYICCGEDHTAILTKEGGVFTFGAGGYGQLGHNSTNHEVN-PRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTSNRKS-PFTVQ 114          

HSP 4 Score: 55.4546 bits (132), Expect = 7.946e-8
Identity = 32/110 (29.09%), Postives = 58/110 (52.73%), Query Frame = 2
Query:  638 PQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAA-LSIDGGVFTWGHGRYGQLGHNNFENKSIPCIV 964
            P  +K+L    +  I  G+  + +LT  G ++++G+  YGQLG + +T++E  P  V  L    +  ++ G+ H  A +   G ++++G G  GQLG  +  N+  P  V
Sbjct:    5 PALLKSLRTQKVVYICCGEDHTAILTKEGGVFTFGAGGYGQLGHN-STNHEVNPRKVFELMGSIVTQIACGRQHTLAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 113          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Match: ube3a (ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-GENE-041114-190])

HSP 1 Score: 252.677 bits (644), Expect = 1.428e-70
Identity = 150/404 (37.13%), Postives = 228/404 (56.44%), Query Frame = 2
Query: 2036 EFSLFDYPFLFDGITKTNL---------MKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQ---CHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVS-LECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLK-FFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +FS    PF+   +TK NL         M  E +  +   L          + VRRD+++ D + +L          LKK   V F GE  +DEGGV KE F LVV ++ NPD G+F     +RL WFN    + N  QF  IG + GLAIYNN ++D+HFP+V+++KL+ ++    DL + +P L +SL+ LL Y +   ED  M  F +S  + +G  I  +L  +G D PVT  N++ +VDLY +YILN++VE+ FK F+ GFH       LK  F+P E++ L+ GS   D+  L  + EY G +  + ++I  FW++      D+K+ FL++ TG DR P+ G+  +K+ I     D + LP AHTC+N+L LP+Y+S   L+++L  AI + +GF ++
Sbjct:  467 KFSFMTCPFILSAVTK-NLGLYYDNRIRMYSERRITVLHSLVQGQHLPYLRLKVRRDHVIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEELFNPDIGMFTFDESTRLFWFNPSSLE-NEGQFTLIGIVLGLAIYNNCILDIHFPMVVYRKLMGKRGTFHDLADSHPALYQSLKDLLAY-EGSVEDDIMATFRISYFDMFGTPITQDLKENGEDIPVTNDNKKEFVDLYAEYILNQSVEKQFKAFRRGFHMVTSESPLKALFRPEEVELLVCGSRVLDFHALEDATEYDGGFNKSSRVIRDFWDTVHDFCEDKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDSDRLPTAHTCFNVLLLPEYSSREKLKERLLKAITHAKGFGML 867          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 154.066 bits (388), Expect = 5.999e-40
Identity = 114/368 (30.98%), Postives = 184/368 (50.00%), Query Frame = 2
Query: 2156 FHITVRRDNLLGDTISQLHRATQCHL-KKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFE----------MYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIE-YELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQP------VNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            F + + R ++L D+  ++    +  L K    + F GE  LD GGV +E F L+  ++ NP YGLFE          + P S LC       +++L  F  IGR+ G+A+++  ++D  F    +K +L +   L+D+  ++     SL  +L+ D  D +    L F +  E +G +    EL  +G +  VT  N++ Y++L + +   + V++    F EGF   +    +K F   EL+ LM G    D    R+   Y   Y  NH +I WFW +   +  +++ + L+++TG  RVP+NG +++     P      +      LP AHTC+N LDLP Y S   LR+KL IAIEN +GF  V
Sbjct:  136 FEMKLHRASILEDSYRRIVAVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPISGLC------NEEHLSYFTFIGRVAGMAVFHGKLLDGFFIRPFYKMMLQKPITLNDMESVDSEYYNSLMWILENDPADLD----LRFCIDEEMFGQQTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNSYCANHPVIQWFWKAVLLMDGEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEMWSTSEKLPRAHTCFNRLDLPPYESFDDLREKLNIAIENAQGFEGV 493          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 150.599 bits (379), Expect = 3.818e-37
Identity = 111/368 (30.16%), Postives = 175/368 (47.55%), Query Frame = 2
Query: 2153 SFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDE-----GGVMKELFLLVVPQVLNPDYGLFEMY--------PESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLD--DLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSE-SYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDI--KIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFAL 3202
              ++T+RR  +  D   +L    +  L++  RV+ +    LDE     GG+ +E    ++    NP  G F           PE+RL     ++ D     +  +GR+ G A+Y N++++L F      KLL    ++D   L  L+P + ++L  L  Y Q D E++  LNF V     G     EL   G D PVT +NR  Y+ L  DY LN+ + Q    F++G    +  + L+ F   ELQ L+ G++   D   L+    Y G Y  +H +I  FW+     + ++K+K L+++T C R P+ G  ++     +     D   LP A TC NLL LP++  E  +  KL  AIE+  GF L
Sbjct:  730 GINVTIRRPYIYEDAYDKLSPENEPDLRRRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKTGFNPHQGFFRTTNQGLLYPNPEARL-----LVGDGFTRHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTTGDVDIHHLASLDPEVYRNLLFLKSY-QGDVEEL-GLNFTVVNNELGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLATVINLEWLRMFDEQELQVLLSGAQVPIDLQDLKNFTNYSGGYTADHPVIKVFWHVVEGFTDEQKRKLLKFVTSCSRPPLLGFKELFPAFCVHNGGADPERLPTASTCMNLLKLPEFLEEETMHGKLLYAIESAAGFEL 1090          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001275.1 (pep scaffold:Pmarinus_7.0:GL476529:184068:212443:-1 gene:ENSPMAG00000001140.1 transcript:ENSPMAT00000001275.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.895 bits (359), Expect = 1.135e-34
Identity = 104/316 (32.91%), Postives = 164/316 (51.90%), Query Frame = 2
Query:  101 SIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFD-HTLFLLKNGKLYSCGNNEFKKLGHDCNKVK--PNQIQ-MLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIK-LVQSLTGHFIVQVACGHDHTLALTKNSEI-FSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENK-SIPCIVMDLLGSKVSQIECGMNHTLAY 1027
            S+ + G  SYG+LG+   N          +   +      S G D HTL +   G+++S G+ ++ KLGH  +  +  P  IQ  L    ++  SAGY H+A VT  G ++TWG+  FG LG    +  +I  LV+ ++   + QVACG  HT+A++++  I +S+G    G+LG GD  + V  P+ I+ L  + I+ + AG + S  LT +G LY+WG       G    T+    P +++ L    IV +S G +H  AL+ D  V+ WG+   GQ G  +  +  + P  VM + G  V QI  G +H+LA+
Sbjct:  430 SVRACGKGSYGRLGLGDSNNQSTLKKLTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQLYAWGCGACLGCGSSEATALR--PKLIEDLACTRIVDISCGDSHCLALTHDNEVYAWGNNSMGQCGQGHSTSPVTKPKKVMGMDGISVQQISAGTSHSLAW 740          

HSP 2 Score: 112.079 bits (279), Expect = 3.888e-25
Identity = 72/245 (29.39%), Postives = 129/245 (52.65%), Query Frame = 2
Query:  389 NAVVTNLGLVFTWGKNS---FGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAG---DKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEI 1105
            + VV+    V+ WG NS     E  ++K+     K+         ++   G   T  +  +  + + G  + G+LGLGD+ +  ST +++       +K I++    D  +  +T  G ++SWG  +YG+LG   +++ +   L+   L+ + +V VS G  H A+++ DG ++TWG G +G+LGH +  +++IP +V D+  S V Q+ CG +HT+A       V++FG G  G+LG  DT  +
Sbjct:  372 SPVVSETSEVYVWGSNSSHQLAEGAQEKI--LQPKMASGFANAQTIEA--GQYCTFVIAVDGSVRACGKGSYGRLGLGDSNNQ-STLKKLTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDTNRV 609          

HSP 3 Score: 108.997 bits (271), Expect = 3.102e-24
Identity = 78/271 (28.78%), Postives = 132/271 (48.71%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXX-XXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLG-LVFTWGKNSFGELGR-DKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHV---AALSIDGGVFTW 898
            +FS+G   YG+LG    N     YP+ I       +   +S G+ H+  + ++G+LY+ G  +F +LGH  +  +     + D   +   + G  H   V+  G +V+++G    G+LG  D    +  K++++L G FI +V  G   +LALT   ++++WG   C  LG G +      P+ I++L+   I  I+ GD     LT    +Y+WG+N+ GQ G+  +TS  + P  V  +    +  +S G +H     AL  D  V  W
Sbjct:  486 VFSWGDGDYGKLGHG--NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQLYAWGCGAC--LGCGSSEATALRPKLIEDLACTRIVDISCGDSHCLALTHDNEVYAWGNNSMGQCGQGHSTSPVTKPKKVMGMDGISVQQISAGTSHSLAWTALPTDRQVVAW 752          

HSP 4 Score: 92.8189 bits (229), Expect = 2.702e-19
Identity = 74/234 (31.62%), Postives = 123/234 (52.56%), Query Frame = 2
Query:  395 VVTNLGLVFTWGKNSFGELG-RDKLSDFSIKLVQSLTGHFIVQVAC--GHD-HTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKS-----ITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGG-VFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLG 1066
            V+   G V   GK S+G LG  D  +  ++K +       + +++   G D HTLA+T   E+FSWG    G+LG G+     S+ Q+   L   P++      ++AG + S  +T  G LY+WG  ++G+LG   + S  ++P +VK +    +  V+ G +H  A+S DG  V+++G G  G+LGH +      P ++  L G  + ++  G   +LA + STG +YA+G G
Sbjct:  424 VIAVDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPQRAVKKISSSRGSDGHTLAVTMEGEVFSWGDGDYGKLGHGN-----SSTQKYPKLIQGPLQGKVVVCVSAGYRHSASVTEDGELYTWGEGDFGRLGHGDSNS-RNIPTLVKDISN--VGQVACGSSHTIAVSQDGRIVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLA-LTSTGQLYAWGCG 648          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 182.185 bits (461), Expect = 1.926e-47
Identity = 138/430 (32.09%), Postives = 221/430 (51.40%), Query Frame = 2
Query: 2006 ELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMS-EGLPCFM--------AQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWF--NKMIFDDN------LPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVS-------LECYGNKIEY---ELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFT-MQGKCLKFFKPIELQELMVGSES---YDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNV-DDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFA 3199
            E W  + +K  FS   YPF+     K ++M+ E + +M  E    F+            F I VRRD +  D++  + +  Q  L KS R+ F+ E  +D GG+ KE F L+   + NP  GLF    ES   WF  +   FD +      L  +   G + GLAI+N+ ++DL FP  ++KKL +E  + +D  EL P   ++L  +L+Y +++FED+F L F  +       L    +  EY   EL  +G + P+T SN+  +V  +V++ L K++E  +  F  GF     +   +K F   EL+ L+ G E    +D+  LR   +Y+G + ++ + + WFW    S  +  +KK L+++T  DR+P  G+S I  KI  +   D + LP+AHTC+N + L  Y+S+  L  KL  AI  +EG+ 
Sbjct:  462 EEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCI-KEHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYG 890          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 158.688 bits (400), Expect = 3.957e-40
Identity = 109/356 (30.62%), Postives = 178/356 (50.00%), Query Frame = 2
Query: 2159 HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWF---NKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNV------DDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFA 3199
            HI VRR N+  D   ++ R T   LKK   + F GE+ LD GGV +E F L+  ++ NP Y LFE             N  I  ++L  F  IGR+ GL +++   +D  F   ++K +L +K  L D+  ++  +  SL  +L   +N  + +  L F    E +G  +  +L  DG +  VT  N++ YV+LY  + +   V++ FK F +GF+  +    +  F   EL+ L+ G    D    +K  +Y G Y  + ++I WFW   S    +++ + L++ TG  R+P+NG  D++    P         +   LP +HTC+N +DLP+Y     ++ KL +A+E   GF 
Sbjct:  456 HIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWML---ENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRG-YQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFG 807          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 153.295 bits (386), Expect = 9.304e-38
Identity = 115/360 (31.94%), Postives = 175/360 (48.61%), Query Frame = 2
Query: 2162 ITVRRDNLLGDTISQLHRATQCHLKKS-FRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWF---NKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDI-------KIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAI-ENNEGFALV 3205
            ITVRR+ +  D+   L   T   +K S   + F GE  +D GGV +E + ++  Q+ NPDY LF   P  +  +       I  ++L  F  IG + G AI +   +D HF   ++K +L    +L D+  L+P   KSL  +L   +ND  DI    F V  + YG      LI  G D  VT +N+Q YV   V+Y L  +V++    F  GF+  +    +  F   EL+ L+ G    D    + +  Y+  Y    + +++FW +  S   +E+ K L+++TG  +VP+NG  ++       K  I         LP +HTC+N L+LP Y S   LR  L +AI E +EGF L 
Sbjct: 2913 ITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWIL---ENDITDIIEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVN-YTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGLA 3268          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 113.235 bits (282), Expect = 7.866e-26
Identity = 108/358 (30.17%), Postives = 167/358 (46.65%), Query Frame = 2
Query: 2168 VRRDNLLGDTISQLHRATQCHLKKSFRVNFM---GEDA-LDEGGVMKELFLLVVPQVL-NPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEK----ANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGS-ESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMS--DIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFAL 3202
            + RDN+L D  +  +   +   K S  V F+   GE+A +D GG+ KE    V  +   +P + LF      R   +  +++D   L     +G++ G  +Y +V+ID+ F     KKLLN      ++  DL   +  L  +L  LL+   ++ + + +   I   E     ++  LI +G    VT  N   YV    DY LNK   +P   F  G    +    ++ F  IELQ L+ G  ++ D   L+ + EY G Y    Q I  FW   +   F+EK  FL+++T   + P+ G    D K  I+    +   LP A TC NLL LP Y +++ILR+KL  AI +   F L
Sbjct:  558 ISRDNVLEDAFNAFNSIGE-RFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFRT--NDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVD--LIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEY-GGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Match: SRM1 (Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant [Source:SGD;Acc:S000003065])

HSP 1 Score: 101.293 bits (251), Expect = 9.578e-23
Identity = 68/256 (26.56%), Postives = 125/256 (48.83%), Query Frame = 2
Query:  248 LLKNGKLYSCGNNEFKK--LGHDCNKVK----PNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLV--QSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFD---MVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLG-----------RDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKS 949
            L  NG++Y+ G     +  LG   +K+K    P ++     + ++  + G DH   +   G+VF WG     +LGR  +  F +K +  +      +  +A G +H  ALTK++++ SWG N  GQ G+ ++ +   +V+ P+++    N+ I+SI AG+  S +L+  G LYS G  +  ++G           +D+     ++PL  K         V+ G +H  A++ +G  ++WG G    +G   FE+ +
Sbjct:  180 LFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDT 435          

HSP 2 Score: 87.4261 bits (215), Expect = 2.897e-18
Identity = 80/342 (23.39%), Postives = 138/342 (40.35%), Query Frame = 2
Query:  347 DAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRD-------------------------KLSDFSIKLVQS-----LTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLG---DNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLG-HNNFENKSI---PCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHW----VPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITA 1249
            D  K+I  + G  H   +     V++WG N  G LGRD                         +L     K+ +        GH +VQ+A   + + AL  N E+++WG   C +  LG   D   +  TP ++   S   I  +  G      L   G +++WG+    QLGR +   +    L  +    + + Y++ G+NH  AL+ D  + +WG  ++GQ G   + E+ ++   P  +       +  I  G +H+L  +   G +Y+ G     ++GI       +T K ++G      +P + NN  K             K +  G +HS+  A
Sbjct:   82 DEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSL-ILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKF------------KSVAAGSHHSVAVA 410          

HSP 3 Score: 57.3806 bits (137), Expect = 8.463e-9
Identity = 62/246 (25.20%), Postives = 110/246 (44.72%), Query Frame = 2
Query:  227 GFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAH-------KLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG-RDKLSDFSI----KLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGL-GDNF------DMVSTPQQIK---NLSNLP-IKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQP--IVYVSVGQNHVAALSIDGGV 889
            G DH LFL + G +++ GN +  +LG     ++  +++ LD         K I  ++G +H   +T    + +WG N FG+ G  + + D ++    K +       I  +A G  H+L L+++ +++S G     ++G+  DN       D+    + +     L+N+P  KS+ AG   S  +  +G  YSWG      +G         +P  +K+   Q   I+ V  G       S+ GGV
Sbjct:  229 GKDHILFLDEEGMVFAWGNGQQNQLGRKV--MERFRLKTLDPRPFGLRHVKYI--ASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGCG----GQFSVSGGV 466          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Match: EDO34592 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNX9])

HSP 1 Score: 620.542 bits (1599), Expect = 0.000e+0
Identity = 393/1077 (36.49%), Postives = 588/1077 (54.60%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXX-XXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELG-----RDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQM-YIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWK----HPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLC-----KLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRN----------VSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGL---------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDD--NYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +F +G  S GQLG+    +++ S P+ ++ +  SS++ ++SCG++HT FL K+G +Y+CG+NEF +LG + +   P  +  ++   +   + G  H   V++ GLVF WG NS+G++G     ++K+     K+++ L    +VQ+ACG +H++ALT +  +F WG N+ GQLG+G     +S P  + +L+ +P   I+AG   SF L+ SG L+ WG N YGQLG   TT    LP ++K LR Q + YVS G+ H A L+ DGGVFT+G G  GQLGHN+  ++  P  V +L+GS V+QI CG  HTLA + S+G VY FG G  GQLG+  T   C++     G W  L  NN   +  E   + + Y V+R+  GG+H    ASS    +   P+D+RL        H +    M++     I + +S +    E++FSSLACL+ SFLD  N V       H   I L  +    F  S  +    +  V    N        +  P +E LR +L+   + I+   E    ++IPF+ S   +       L +W   L   YF +   VF   +   +           F++  E + V+  +C      LH++N +   I+ +  F  P+  +V D+   Y  W++N          V K  FS   +PF+FD   KT L++ +A   M   +               P         I VRRD+++ DT++Q+   +   LKK  +V F  E+A+D GGV KE FLL++ ++L+P YG+F    +S+  WFN + F+++ P F  IG + GLAIYN+ + DL FP V++KKLL +K NLDD     P++ ++LQ LLDY  +D ED F LNF +  E YG     +L+  G + PVT  NR+ YV+LY+DY L+K V++ F+ F  GFH    G  L+FF P EL E++VG + YD+ +L K  EY GEY+  H +I  FW  F       KKKFL +LTG DRVPI GM  +K+ IQPV   +  ++LPVAHTC+NLLDLP+Y +  ++R KL  A+E ++GF L 
Sbjct:    1 MFCWGKCSEGQLGVGETEQEFISTPRLLENLEFSSNVREVSCGWNHTAFLCKDGTVYTCGSNEFGQLGQEKSHTNPESVHAIETFTITKVTCGKAHTVAVSDQGLVFAWGDNSYGQIGLGSKVKEKVQTIP-KMLKGLAKMSVVQIACGCNHSMALTISGHLFCWGDNSSGQLGIGKTHSSMSEPAPVLSLNGVPFMLISAGGAHSFALSSSGALFGWGKNEYGQLGVHDTTD-RPLPTLLKSLRSQGVCYVSCGEKHTAVLTSDGGVFTFGCGTSGQLGHNSNHHEYTPRKVFELMGSVVTQIACGRAHTLALVPSSGRVYTFGRGGDGQLGLGVTNN-CNSPMTAKGPW--LRSNNIKSMLPEADGDSVVYTVRRIDAGGDHCFAMASSYG-DETDGPEDMRLPRPSQSILHLSVPVTMDLVKRATIASDLSDVSEKLEIIFSSLACLNGSFLD--NVVHPYVMPIHPCLIPLYVH----FIHSHLTPLPPSQIVSCISNFLLPAMVQQQPPDIEALRVYLMLPENGIMLDKECFMEVVIPFADSILRLSPEAQKVLRRWWSTLPSTYFSRVIQVFQECVKYLLT-----LPLPHFAN--EERQVYLGMCMVALDNLHKVNNESGDIVPFKQFTFPRTREV-DIRADYFNWIQNQKINLKHQHSVVKNTFSFCRFPFVFDASAKTKLLQTDAVMQMQSAVDEVNRRNVQSLLSFVPVNPVNPCLVIKVRRDSIVQDTLTQITTQSPYDLKKPLKVIFANEEAVDAGGVKKEFFLLLLTEILDPKYGMFTYLEDSQTIWFNDLTFEES-PMFLLIGVICGLAIYNSTIFDLRFPPVLYKKLLRKKPNLDDFRGFQPSVARNLQYLLDYSDDDLEDTFGLNFQIMREKYGALEYIDLVPGGGEVPVTQDNREQYVELYIDYYLSKAVDKQFEAFFTGFHRVCGGHVLEFFHPQELMEMVVGCQEYDFEVLEKITEYKGEYYRKHPVIANFWTVFYEFPLSMKKKFLAFLTGSDRVPILGMESMKMIIQPVAGGEHGDHLPVAHTCFNLLDLPRYPTLEMMRTKLSQAVEFSKGFGLA 1056          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Match: EDO40462 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S732])

HSP 1 Score: 259.61 bits (662), Expect = 3.847e-73
Identity = 142/354 (40.11%), Postives = 213/354 (60.17%), Query Frame = 2
Query: 2156 FHITVRRDNLLGDTISQLHRATQ---CHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLK-FFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
              + VRRD+L+ D +  L    Q     LKK   V F GE  +DEGGV KE F L+V Q+ NPDYG+F     +R+CWFN   F+ +  QF  IG + GLAIYNN+++D+HFP+V+++KL  +   ++DL + +P L  SL  LL Y+ N  ED+     I   + +G+ + +EL  +G   PVT  NRQ YV+L+ D+ILNK+VE+ F  F+ GF   +    LK FF+P E++ L+ GS+ +D+  L K+ EY G    +  +I WFW    S   ++K++ L + TG DR+P+ G++ +K+ I     D   LP AHTC+N+L LP Y ++  L ++L  AI + +GF L+
Sbjct:  445 LRLKVRRDHLIEDALVSLEMVAQDNPLDLKKQLFVEFEGEQGIDEGGVSKEFFQLIVEQIFNPDYGMFTYDEATRICWFNPTSFESD-AQFCLIGLVLGLAIYNNIILDIHFPMVVYRKLFGKPGTVEDLKDSHPVLYMSLTELLTYEGNVEEDLMCTFKIGYTDVFGSDLTHELKANGESIPVTKENRQEYVNLHADFILNKSVEKQFTAFKRGFDMVVDESPLKIFFRPDEVEMLVCGSKDFDFDALEKATEYDGGLTKDSALIRWFWEIVHSFDMEQKRQLLMFTTGSDRIPVGGLAKLKLIIAKNGPDSPRLPTAHTCFNVLLLPDYATKEKLEERLLKAITHAKGFGLL 797          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Match: EDO40302 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7U7])

HSP 1 Score: 254.603 bits (649), Expect = 3.508e-72
Identity = 171/518 (33.01%), Postives = 266/518 (51.35%), Query Frame = 2
Query: 1781 FKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRI-IHYNTFYIPKIPKVFDLEYSYELW--LRNVSKI--------EFSLFDYPFLFDGITKTNLMKIEAKCLM------------------------------SEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMG--EDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            F +   VF   + + ++    Q+++    +I ++  +F    K+ Q +   ++     + FY  ++ K  D +  Y  W   R +SK+           + D+PFL D  +K  +M I+A   M                              ++G+   M      + VRRD+L+ DT+SQ+H   +  LKK  ++ ++G  E  LD GG+ KE F ++V  +  P YG+F    ESR  W N   F+ +L +F  +G + GLAIYN +++D+HFP V++KKL  +  +L+DLI + P+LG SL+ LL+Y+  D ED F   F VS   YG   + ELI +G + PV   NR+ +V  YV Y+L  +V + F  F  GFH    G  L  F   EL+ L+ G    D+  L  +  Y   Y   H  I  FWN F+ ++  +KK  L ++TG DRVP+ G+S++   IQ    D + LP A TC+N L LP+YTS   L+++L +AIEN++GF L 
Sbjct:  186 FSRLTRVFCGFLGSHVH--PSQSSESHLMEICKVIGIFFDAYKVIQGSSRPDKTSFQLSVFYCDELSKKLDFKKEYGNWQMARRLSKLPGYSTDKDSLCILDFPFLLDPASKVKVMHIDAVWQMRVEYQNAIVHQARVQQVQRIFEETEKSKKLNDGVKAAMC-PFLVLEVRRDHLIRDTLSQIH-LKEYDLKKPLKIKYVGGGELGLDMGGLQKEFFHMIVDSIFEPGYGMFTYIEESRTMWINGESFE-SLKEFELVGIVLGLAIYNGIILDIHFPQVIYKKLQGQTPSLEDLIGVQPSLGNSLKQLLEYE-GDVEDTFCYTFQVSAMSYGKVCDRELIPNGAEVPVNNENREEFVHRYVKYLLVDSVAKQFDAFSAGFHKVCGGSALTLFCADELELLICGHHVLDFSDLVLAASYDDGYSAQHSTIKMFWNVFNEMTNHQKKALLMFVTGSDRVPLKGLSNLTFIIQKHGQDSDRLPTAMTCFNRLLLPEYTSPKRLKERLIVAIENSKGFGLT 697          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Match: EDO34126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQ93])

HSP 1 Score: 235.728 bits (600), Expect = 2.322e-66
Identity = 157/440 (35.68%), Postives = 235/440 (53.41%), Query Frame = 2
Query: 1988 DLEYSYELWLR-NVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSF-----------------HITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKA---------------NLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNV--DDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFAL 3202
            DL   Y  W     +  +FS   YPF+     K  +M+ +++  M       MA+ S                  +I VRR +L+ D+++++ R  + +LKK  +V F GE  LD GG+ KE FLL+V ++  P+YG+F    +SRL WFNK   D +  +FN +G L GLA+YN++++D+HFP   +KKLL+                   L+DL E+ P L + L+ LL Y + D E+     F VS   YG  + + L   G   PVT +NRQ YV LYVDY+LN ++ + F+ F  GFH       L   +P E++ L+ G+   D   L+K   Y G Y  N   I +FW++  + + D KKK L + TG DR+PI GM++++ KI  ++     + LP+AHTC+N L LP Y +   ++ KL IAI N EGF +
Sbjct:  181 DLMAEYYSWQNPGANSGKFSFCQYPFILSLGAKRYIMQKDSESQM-----IVMARKSLMEKVQRREMPDMGMLFLNIKVRRSHLITDSLNEIARKQK-NLKKKLKVTFAGEPGLDMGGLTKEWFLLLVRKIFKPEYGMFSCNDKSRLYWFNKECLDQD-EEFNLVGVLMGLAVYNSIILDIHFPSCCYKKLLSPAVVPFHNPNARVGLANLGLEDLAEVMPELARGLKELLSY-EGDVENDLCQTFQVSFTSYGEVVTHNLKPKGDTIPVTNTNRQEYVQLYVDYLLNSSIYKQFEAFYHGFHSVCASNALIMLRPEEVEMLVCGNPELDMEALKKVTVYDG-YSKNDNTIRYFWDTVMNFNTDLKKKMLLFATGSDRIPIGGMAEMEFKIVRMDTAHSTSMLPMAHTCFNQLCLPPYKTRKQIKQKLTIAISNAEGFGI 611          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Match: EDO49327 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHD5])

HSP 1 Score: 164.466 bits (415), Expect = 2.312e-44
Identity = 116/372 (31.18%), Postives = 192/372 (51.61%), Query Frame = 2
Query: 2117 MSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCW---FNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFM-LNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDI-------KIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFA 3199
            M+  LP     S   ITV R NL  ++  Q+ R     L++   + F GE+ LD GGV +E F L+  +VLNP Y LFE   ++           +  D+L  F  IGR   +A+Y+   ID  F L  +K++LN+K  + DL  ++P    SL  +    +N+ E+  + + F V +E  G    ++L   G D  VT  N++ Y+ L  ++ LN+ +E+  + F EG H  +    +++F   EL+ ++ G +  D    +++  Y   Y  N + + WFW +  +   +++ + L+++TG  R+P+ G +++       K  I+ V   + +LP +HTC+N LDLP Y S   L +KL  AIE  EGFA
Sbjct:    1 MANTLP-----SHIKITVSRTNLFEESFQQVMRYQPHDLRRRLYITFKGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNNYSLQINAASSVNPDHLMYFKFIGRFIAMALYHGKFIDRGFTLPFYKRMLNKKLLMKDLETIDPEFYNSLVWV---KENNIEECGLEMFFTVDMELLGKVTSHDLKPGGTDIAVTEENKEEYISLMTEWRLNRGIEEQTRAFLEGMHEVLPLYWIQYFDERELELMLCGMQEIDVEDWQQNTVYR-HYTRNSKQVMWFWQAVKAYDNEKRIRLLQFVTGTCRLPVGGFTELMGDNGPQKFCIEKVG-KETWLPRSHTCFNRLDLPPYKSYEQLVEKLTFAIEETEGFA 362          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:NCBI gene;Acc:101174618])

HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0
Identity = 390/1081 (36.08%), Postives = 594/1081 (54.95%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPL---------ECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPT-NITVMNVDVNEPI-YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCK--------LHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWL-RNVSKIE----FSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P+K +      +  + CG  HT FLL++G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G VF+WG  S G+LG +   +  I++   ++SL+   + QVACG+ H+LAL+K   IFSWG N  GQLGLG     +S PQ +++L  +P   I AG   SF LT SG ++ WG N +GQLG +  T+    P ++K LR Q ++Y+S G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+G+ V+QI CG  HTLA+  S+G + +FGLG  GQLG   T     +  P+ G W            E  +    SG    E   +V R+Y GG+ S    SS    + +  D ++  + +  T N  V+   +N+P     +   K I  +  S+     S         F  S    G++++    ++ +    +  +  + +A  ++ N+  ++  + + P +E LR +L    S +         I IPF+ S   + E P   L  W   L+P  F++   ++ + +   +         K     +E + +F C           LH++NE   +II Y+ FYI ++ ++ D+ + Y  W+ R +  +      +L  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GDT+  L ++     KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  + +SRL WF+   F+D +  FN IG + GLAIYN  +++LHFPL ++KKLL +K  LDDL EL P +G+SLQ LLDY ++D E+ F LNF ++ E YG    +EL+ +G +  V   NRQ +V+ YVDY+ N +V   F+ F  GFH    GK L+ F+P ELQ +++G+ +YDW  L KS EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQP    + +LPVAHTC+NLLDLPKYTS   LR+KL  AI++N GF L 
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVVEPRKCEFFHGKRVRDVGCGRRHTAFLLEDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQIIVALSCGESHTLALNDKGQVFSWGLGSDGQLGLNNFEE-CIRVPRNIKSLSDVQVAQVACGYWHSLALSKGGHIFSWGQNRYGQLGLGMTGQSISVPQHLQSLQGIPFAQIAAGGAHSFALTLSGAVFGWGRNKFGQLGLN-DTNDRCFPALLKALRSQRVIYISCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGNVVTQIACGRQHTLAFTPSSGKMDSFGLGGNGQLGTRSTCNR-KSPAPVKGPWASSSASSDSDAGEAADTGAPSGPDIGESC-VVNRIYAGGDQSFAHYSSSSNEQMMESDRIQGLHRRICTVNEDVLQTWLNQPAGRLPLEMSKEIDLIFSSASCINGSFLSSSHPDHFSTSSKCSGVDMNTARLLLHKVTQKEHREISEQVAASLEKNLIPRL--SPSPPDIEALRLYLTLPESPLFWDRNNFVTITIPFAKSVVSLKEAPLKVLGNWWSTLEPPVFQRLVDLYRDVVLYLLQ------MHKVGIPSVESR-IFTCFLDTSLRLLELLHKVNERAGQIIRYDKFYIHELDELIDIRHDYVTWIQRQMYPLGHDGVVTLCKYPFVFDAQAKTTLLQTDAVIQMQMAVDQAQLQNFSSMFMPAVESVNPCLI------LIVRRENIVGDTMEVLRKSKNVDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMKELLDPKYGMFRYHEDSRLIWFSNKTFED-IDLFNLIGLICGLAIYNLTIVELHFPLALYKKLLKKKPTLDDLKELMPDVGRSLQQLLDYTEDDVEETFCLNFTITEENYGATEVHELVPNGEELSVNKGNRQDFVNAYVDYVFNSSVASLFECFYSGFHKVCGGKVLELFQPSELQAMVIGNTNYDWTELEKSTEYKGEYWAEHPTIKLFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFLPVAHTCFNLLDLPKYTSPEALREKLLQAIDHNRGFNLA 1061          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Match: herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:NCBI gene;Acc:101174618])

HSP 1 Score: 639.802 bits (1649), Expect = 0.000e+0
Identity = 390/1072 (36.38%), Postives = 596/1072 (55.60%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKL---VQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPT-NITVMNVDVNEPI-YTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCK--------LHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWL-RNVSKIE----FSLFDYPFLFDGITKTNLMKIEAKCLMSEGL--------------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G ASYGQLG+   +++    P+K +      +  + CG  HT FLL++G +Y+CG N+  +LGH+ ++ KP Q+  LDA  ++  S G  H   + + G VF+WG  S G+LG +   +  I++   ++SL+   + QVACG+ H+LAL+K   IFSWG N  GQLGLG     +S PQ +++L  +P   I AG   SF LT SG ++ WG N +GQLG +  T+    P ++K LR Q ++Y+S G++H AAL+ +GGVFT+G G YGQLGHN+  ++  P  V +L+G+ V+QI CG  HTLA+  S+G + +FGLG  GQLG   T     +  P+ G W     ++ S I GE+      +V R+Y GG+ S    SS    + +  D ++  + +  T N  V+   +N+P     +   K I  +  S+     S         F  S    G++++    ++ +    +  +  + +A  ++ N+  ++  + + P +E LR +L    S +         I IPF+ S   + E P   L  W   L+P  F++   ++ + +   +         K     +E + +F C           LH++NE   +II Y+ FYI ++ ++ D+ + Y  W+ R +  +      +L  YPF+FD   KT L++ +A   M   +                    PC +      + VRR+N++GDT+  L ++     KK  +V F+GEDA+D GGV KE FLL++ ++L+P YG+F  + +SRL WF+   F+D +  FN IG + GLAIYN  +++LHFPL ++KKLL +K  LDDL EL P +G+SLQ LLDY ++D E+ F LNF ++ E YG    +EL+ +G +  V   NRQ +V+ YVDY+ N +V   F+ F  GFH    GK L+ F+P ELQ +++G+ +YDW  L KS EY GEYW  H  I  FW  F  L  ++KK+FL +LTG DR+PI GM  +K+ IQP    + +LPVAHTC+NLLDLPKYTS   LR+KL  AI++N GF L 
Sbjct:    1 MLCWGNASYGQLGLGGIDEEIVVEPRKCEFFHGKRVRDVGCGRRHTAFLLEDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQIIVALSCGESHTLALNDKGQVFSWGLGSDGQLGLNNFEE-CIRVPRNIKSLSDVQVAQVACGYWHSLALSKGGHIFSWGQNRYGQLGLGMTGQSISVPQHLQSLQGIPFAQIAAGGAHSFALTLSGAVFGWGRNKFGQLGLN-DTNDRCFPALLKALRSQRVIYISCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEVNPRKVFELMGNVVTQIACGRQHTLAFTPSSGKMDSFGLGGNGQLGTRSTCNR-KSPAPVKGPWASSSASSDSDI-GESC-----VVNRIYAGGDQSFAHYSSSSNEQMMESDRIQGLHRRICTVNEDVLQTWLNQPAGRLPLEMSKEIDLIFSSASCINGSFLSSSHPDHFSTSSKCSGVDMNTARLLLHKVTQKEHREISEQVAASLEKNLIPRL--SPSPPDIEALRLYLTLPESPLFWDRNNFVTITIPFAKSVVSLKEAPLKVLGNWWSTLEPPVFQRLVDLYRDVVLYLLQ------MHKVGIPSVESR-IFTCFLDTSLRLLELLHKVNERAGQIIRYDKFYIHELDELIDIRHDYVTWIQRQMYPLGHDGVVTLCKYPFVFDAQAKTTLLQTDAVIQMQMAVDQAQLQNFSSMFMPAVESVNPCLI------LIVRRENIVGDTMEVLRKSKNVDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMKELLDPKYGMFRYHEDSRLIWFSNKTFED-IDLFNLIGLICGLAIYNLTIVELHFPLALYKKLLKKKPTLDDLKELMPDVGRSLQQLLDYTEDDVEETFCLNFTITEENYGATEVHELVPNGEELSVNKGNRQDFVNAYVDYVFNSSVASLFECFYSGFHKVCGGKVLELFQPSELQAMVIGNTNYDWTELEKSTEYKGEYWAEHPTIKLFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQPTGGGEQFLPVAHTCFNLLDLPKYTSPEALREKLLQAIDHNRGFNLA 1047          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:101155493])

HSP 1 Score: 571.622 bits (1472), Expect = 0.000e+0
Identity = 364/1069 (34.05%), Postives = 575/1069 (53.79%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIK---LVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKH---PTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQI--QYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF------------SLFDYPFLFDGITKTNLMKIEAKCLMSEGL---------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            +  +G A  GQLGI       +  P+     S   +++++CG  HTLFLL++G +Y+CG+N   +LGHD     P  +  LD  K+   S G  H+  V   G VF WG    G+LG +  ++ +++   L++ L  H I QV CG+ H +AL+++ ++F+WG N+ GQLGLG       +P  +K+L+ +P+  ITAG    F L+ SG ++ WG N  GQLG +      ++P  +K LR Q +VY+S G  H AAL+  GG+FT+G G  GQLGH +  N+ +P  VM+L+G++VSQI CG +HTLA++ S+GTVYAFG    GQLG     ++  +  P+   ++ L      +          Y V ++  GG+HS +  SS  C +   P+D R++N      P N   +N    + +Y + S +     V  SS AC ++SFLD  +   H         IDL  N +   F++ S      +  +   +  S +  Q  R+ P +E +R +LI +    L+ S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G  G+                  L KLH++N   + +  YN FYIP I  + D++  Y  W  + ++I+             +L  +PF+ +   KT +++ +A+  M   +               P         + VRR++L+ DT+ +L   +   LKK  +V F GE+A+D GG+ KE FLL++ ++++P YG+F  Y ES L WF+   F +    F+ IG + GLAIYN+ ++DLHFPL ++KKLL+   +L+D  EL+PT  +SLQ LLDY+  D E  F+LNF ++ E YG     EL+  G    V  +NR+ +VD Y+ Y+ + +V++ +  F  GF     G+ L  F+P EL  ++VG+ +Y+W  L K+  Y GEY   H  +  FW  F     ++KK+FL +LTG DR+PI+GM  ++I IQ    +++YLPVAHTCYNLLD+P+Y ++ ILR +L  A+E  EGF+LV
Sbjct:    1 MLCWGNARDGQLGIGVEGNPVFE-PRICHVFSGRGLKEVACGGQHTLFLLQDGSVYTCGSNSCGQLGHDKAGNSPELVGALDTQKITMVSCGRAHSVAVNEQGQVFVWGAGDGGQLGLET-AETAVRIPRLLKKLCDHSISQVVCGNQHCIALSRDGQLFTWGQNSSGQLGLGKGETSKLSPSPVKSLAGIPLAQITAGGDHCFALSLSGAVFGWGKNKAGQLGLN-DKQDRAVPCHIKFLRSQRVVYISCGDEHTAALTKSGGLFTFGDGSRGQLGHGSSNNELLPRRVMELMGTEVSQITCGRHHTLAFVPSSGTVYAFGCNSHGQLGTGILADL-RSPHPVKNDFLTLNLRKDLR---------KYTVIKIICGGDHSFLMYSSEQCPE--VPEDFRVFNVSKSLSPINHDCLNSWRLKLLYNTDSNVTKDMIVHLSSTACWNASFLDQSDDA-HFKTNPKIPGIDL--NSVRMLFATLSKPAFAGIQEQATTSFESLLIPQLPRSPPDVEAMRIYLILSEYPALQDSKNYIRLTIPLAIAILQLDTNPSKVLDNWWCVVDVGVFTRMVDMYKSIVVYMLTG--GKTVPAPVLHENYFMATLRLLEKLHKVNLKAHHV-EYNHFYIPDITSLVDIQEDYLKWFLSKAQIKVGSSPSQSNLPPVNLCAFPFILNAQAKTTMLQTDAELQMQMAVSGANLHNVFMLLTLEPHLARNPYLVLHVRRNHLVSDTLRELTVYSDVDLKKPLKVIFDGEEAVDAGGLTKEFFLLLLKELMDPVYGMFTYYKESNLLWFSDKCFVEQ-NWFHLIGIICGLAIYNSTVVDLHFPLALYKKLLDVSPSLEDFKELSPTEARSLQQLLDYEGRDVEGTFLLNFAITRENYGMTEVKELVPGGESIAVDNTNRKEFVDSYLRYVFSDSVDEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEELEKNAVYKGEYSATHPTVKLFWEVFHEFPLEKKKQFLLFLTGSDRIPIHGMESLRIIIQSTTAEEHYLPVAHTCYNLLDMPRYQTKEILRRRLTQAVEQYEGFSLV 1047          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Match: herc3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:NCBI gene;Acc:101155493])

HSP 1 Score: 471.855 bits (1213), Expect = 1.128e-148
Identity = 314/966 (32.51%), Postives = 505/966 (52.28%), Query Frame = 2
Query:  104 IFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIK---LVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKH---PTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQI--QYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEF------------SLFDYPFLFDGITKTNLMKIEAKCLMSEGL---------------PCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRK 2896
            +  +G A  GQLGI       +  P+     S   +++++CG  HTLFLL++G +Y+CG+N   +LGHD     P  +  LD  K+   S G  H+  V   G VF WG    G+LG +  ++ +++   L++ L  H I QV CG+ H +AL+++ ++F+WG N+ GQLGLG       +P  +K+L+ +P+  ITAG    F L+ SG ++ WG N  GQLG +      ++P  +K LR Q +VY+S G  H AAL+  GG+FT+G G  GQLGH +  N+ +P  VM+L+G++VSQI CG +HTLA++ S+GTVYAFG    GQLG     ++  +  P+   ++ L      +          Y V ++  GG+HS +  SS  C +   P+D R++N      P N   +N    + +Y + S +     V  SS AC ++SFLD  +   H         IDL  N +   F++ S      +  +   +  S +  Q  R+ P +E +R +LI +    L+ S+    + IP +++   +   PS  L+ W   +    F +   ++ + +   + G  G+                  L KLH++N   + +  YN FYIP I  + D++  Y  W  + ++I+             +L  +PF+ +   KT +++ +A+  M   +               P         + VRR++L+ DT+ +L   +   LKK  +V F GE+A+D GG+ KE FLL++ ++++P YG+F  Y ES L WF+   F +    F+ IG + GLAIYN+ ++DLHFPL ++KKLL+   +L+D  EL+PT  +SLQ LLDY+  D E  F+LNF ++ E YG     EL+  G    V  +NR+ +VD Y+ Y+ + +V++ +  F  GF     G+ L  F+P EL  ++VG+ +Y+W  L K
Sbjct:    1 MLCWGNARDGQLGIGVEGNPVFE-PRICHVFSGRGLKEVACGGQHTLFLLQDGSVYTCGSNSCGQLGHDKAGNSPELVGALDTQKITMVSCGRAHSVAVNEQGQVFVWGAGDGGQLGLET-AETAVRIPRLLKKLCDHSISQVVCGNQHCIALSRDGQLFTWGQNSSGQLGLGKGETSKLSPSPVKSLAGIPLAQITAGGDHCFALSLSGAVFGWGKNKAGQLGLN-DKQDRAVPCHIKFLRSQRVVYISCGDEHTAALTKSGGLFTFGDGSRGQLGHGSSNNELLPRRVMELMGTEVSQITCGRHHTLAFVPSSGTVYAFGCNSHGQLGTGILADL-RSPHPVKNDFLTLNLRKDLR---------KYTVIKIICGGDHSFLMYSSEQCPE--VPEDFRVFNVSKSLSPINHDCLNSWRLKLLYNTDSNVTKDMIVHLSSTACWNASFLDQSDDA-HFKTNPKIPGIDL--NSVRMLFATLSKPAFAGIQEQATTSFESLLIPQLPRSPPDVEAMRIYLILSEYPALQDSKNYIRLTIPLAIAILQLDTNPSKVLDNWWCVVDVGVFTRMVDMYKSIVVYMLTG--GKTVPAPVLHENYFMATLRLLEKLHKVNLKAHHV-EYNHFYIPDITSLVDIQEDYLKWFLSKAQIKVGSSPSQSNLPPVNLCAFPFILNAQAKTTMLQTDAELQMQMAVSGANLHNVFMLLTLEPHLARNPYLVLHVRRNHLVSDTLRELTVYSDVDLKKPLKVIFDGEEAVDAGGLTKEFFLLLLKELMDPVYGMFTYYKESNLLWFSDKCFVEQ-NWFHLIGIICGLAIYNSTVVDLHFPLALYKKLLDVSPSLEDFKELSPTEARSLQQLLDYEGRDVEGTFLLNFAITRENYGMTEVKELVPGGESIAVDNTNRKEFVDSYLRYVFSDSVDEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEELEK 944          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Match: ENSORLT00000015298.2 (probable E3 ubiquitin-protein ligase HERC4 [Source:NCBI gene;Acc:101161054])

HSP 1 Score: 312.383 bits (799), Expect = 9.764e-90
Identity = 269/957 (28.11%), Postives = 452/957 (47.23%), Query Frame = 2
Query:  512 IVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXX------XDIKNSVFHISQTNHGLNI---DLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQ---------YNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNK-----------WIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKF-------------SDIIEMKPVFD---CLCKLHQ--INED--------HNRIIHYNTFYIPKIPKVFDLEYSYELWLR--NVSKIEFSLFD-----YPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVD--DNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNE 3190
            + QVACG  HT+ALTK  ++++WG N+ GQLGLG     +S+PQ +++LS +P+  ++AG   SF L+ SG ++ WG N+ GQLG    +     P  V  L  +    +S G++H A L+  G VFT+G G++GQLGHN+  N+  P +V +L G+KV++I CG  HTL  +     +Y+FG     QLG  +     H +       VPL       I G         ++ ++ G N S    + L   +K + D     N  +  N   + ++     +TS S MK+  +         SS+       L+ K+  F  S   HGL++    L+F  + +                 K N++ +++          ++N   +E LR +L+        ++E  +          + + E  + A+ +           W  +L P    +   V+  A++  ++  +G +T                 S + E + + D   CL KL +  ++ED        H  I+      +P    V DL+    ++ +  + +K+E +L D     + +++D  T+ NL             P  M      + +RR ++L DT  QL    Q   KKS  V F      DE   +K+ F  V  ++++P+YG+F       L WF      ++  +F   G L GLA+YN V+I L FPLV+FKKLL    +L+DL E +P+  K+L  +L     ++ D  + N  +  +   +K   +L     +KPVT  N++ +VD YV+Y  N +V++ F+ F  GF      + +K F+P EL   +VG++ ++W  L+++  Y G Y  +H  I  FW  F  LS ++K  F+ ++TG +R+PI+ +  I I  + ++ D  D Y P + TC+ LL LP Y+S+ I+ +KL  A+ +N 
Sbjct:  119 VSQVACGSRHTVALTKEGQVYTWGQNSRGQLGLGKKGCSISSPQCVRSLSGMPLVQVSAGGDHSFALSVSGSVFGWGRNDCGQLGLG-DSQDRCTPTSVDSLNLKKTTSISCGKDHTAILTKHGTVFTFGSGQFGQLGHNSSRNELRPRLVAELWGAKVTRIACGRYHTLV-LQENNKIYSFGCNDQNQLGRSND---SHPS-------VPLPVLLPQDIGGTK-------IRTIFAGENCSF---APLTTDEKFHRDS----NCDNANNKAQLCLENMVKRWTSESDMKTWKKTKQEIQRTFSSASCLNRSFLEKKDKYFQTSPKYHGLDLKRAQLSFKKLVK-----------------KKNVWEEVEAALLRLLPLLDKNPVGVEGLRIYLL--------LNELLRATQTQNPQQSTKLAEVVAAAVTRLSGKNLQVIGDWWSSLMPSRRVRHVNVWKKAVSAMLSSEDGSHTPAVRNLLLVLQYMYNVNSRVAECQRLPDSVFCL-KLSEAFLDEDGIRWYLRSHGEIMMSEPRVLPNFSFVMDLKAKMLIFQKMCDATKVEKALGDLSSLLWSYMWD--TQNNL-------------PGLM------LDLRRASVLEDTFEQLAATQQEDYKKSLVVIFDDNPVFDEV-YIKDFFYEVFHEIVSPEYGMFMFNDSKTLAWFPSKAQQED-QRFFLFGVLCGLALYNQVIIFLPFPLVLFKKLLGVTPSLEDLREFSPSEYKTLHCIL----YEYTDDVLENLFIDFQITWDKTCIDLDPAFPEKPVTGQNKKEFVDAYVNYAFNTSVKRIFQEFARGFFKVCDRELVKLFRPEELHRALVGNDFHEWEKLKQNTLYDGGYNPSHTNILMFWEVFDELSENQKMAFVWFVTGYERLPISALEKITISTKKISEDFGDRYYPESETCFRLLVLPLYSSKEIMTEKLVEALSSNR 996          

HSP 2 Score: 140.584 bits (353), Expect = 2.545e-33
Identity = 86/276 (31.16%), Postives = 142/276 (51.45%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDK--LSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVM---DLLGSKVSQIECGMNHTLAYMVS 1036
            CG D  + L + G +Y     +   L        P  ++      +   + G  H   +T  G V+TWG+NS G+LG  K   S  S + V+SL+G  +VQV+ G DH+ AL+ +  +F WG N CGQLGLGD+ D   TP  + +L+     SI+ G   + +LT  G ++++GS  +GQLG + ++  E  P +V  L    +  ++ G+ H   L  +  ++++G     QLG +N  + S+P  V+   D+ G+K+  I  G N + A + +
Sbjct:   82 CGDDEVILLSEKGSVYRVDVTQALYL--------PRMLEAFCRIPVSQVACGSRHTVALTKEGQVYTWGQNSRGQLGLGKKGCSISSPQCVRSLSGMPLVQVSAGGDHSFALSVSGSVFGWGRNDCGQLGLGDSQDRC-TPTSVDSLNLKKTTSISCGKDHTAILTKHGTVFTFGSGQFGQLGHN-SSRNELRPRLVAELWGAKVTRIACGRYHTLVLQENNKIYSFGCNDQNQLGRSNDSHPSVPLPVLLPQDIGGTKIRTIFAGENCSFAPLTT 347          

HSP 3 Score: 118.627 bits (296), Expect = 1.276e-26
Identity = 81/272 (29.78%), Postives = 119/272 (43.75%), Query Frame = 2
Query:  302 GHDCNK------VKPNQIQMLD-AHKLIDASAGYDHNAVVTNLGLVFTW----GKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLG 1084
            G DC +         + +Q+L  +  + D SAG    A     G  F      G+N     G+ K      K         I  V CG D  + L++   ++             D    +  P+ ++    +P+  +  G + +  LT  G +Y+WG N+ GQLG        S P  V+ L   P+V VS G +H  ALS+ G VF WG    GQLG  + +++  P  V  L   K + I CG +HT A +   GTV+ FG G+FGQLG
Sbjct:    5 GEDCRRGFRLMDSGDDGVQLLHVSFHIADLSAGRGALAFAKTNGNAFVMRTSDGENGARMRGKQKFVKCKEK---------IEAVGCGDDEVILLSEKGSVYR-----------VDVTQALYLPRMLEAFCRIPVSQVACGSRHTVALTKEGQVYTWGQNSRGQLGLGKKGCSISSPQCVRSLSGMPLVQVSAGGDHSFALSVSGSVFGWGRNDCGQLGLGDSQDRCTPTSVDSLNLKKTTSISCGKDHT-AILTKHGTVFTFGSGQFGQLG 255          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Match: SMESG000033113.1 (SMESG000033113.1)

HSP 1 Score: 2094.32 bits (5425), Expect = 0.000e+0
Identity = 1050/1053 (99.72%), Postives = 1051/1053 (99.81%), Query Frame = 2
Query:   47 LTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            LTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNK KPNQIQMLDAHKLIDASAGYDHNAVVT+LGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIR GYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV
Sbjct:  401 LTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKFKPNQIQMLDAHKLIDASAGYDHNAVVTDLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRGGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 1453          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Match: SMESG000033113.1 (SMESG000033113.1)

HSP 1 Score: 2084.69 bits (5400), Expect = 0.000e+0
Identity = 1050/1054 (99.62%), Postives = 1051/1054 (99.72%), Query Frame = 2
Query:   44 RLTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
             LTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNK KPNQIQMLDAHKLIDASAGYDHNAVVT+LGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIR GYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV
Sbjct:  116 ELTLYFKLNFEFIIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKFKPNQIQMLDAHKLIDASAGYDHNAVVTDLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRGGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 1169          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Match: SMESG000033113.1 (SMESG000033113.1)

HSP 1 Score: 2027.68 bits (5252), Expect = 0.000e+0
Identity = 1034/1037 (99.71%), Postives = 1035/1037 (99.81%), Query Frame = 2
Query:   95 MISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVXXXXXXXXXXXXXDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            MISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNK KPNQIQMLDAHKLIDASAGYDHNAVVT+LGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIR GYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV
Sbjct:    1 MISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKFKPNQIQMLDAHKLIDASAGYDHNAVVTDLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIKNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFSLFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLECYGNKIEYELIRGGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIINWFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 1037          

HSP 2 Score: 92.8189 bits (229), Expect = 1.004e-18
Identity = 65/195 (33.33%), Postives = 105/195 (53.85%), Query Frame = 2
Query:   80 IIILKMISIFSFGAASYGQLGIDPRNKDYYSYPQXXXXXXXXXXXXXXCGFDHTLFLLKNGKLYSCGNNEFKKLGHDCN---KVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFSIK-LVQSLTGHFIVQVACGHDHTLA-LTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQI 649
            + + K   IFS+GA + GQLG+   N D  S PQ+I  +S+  I+ I+ G   +  L  +G LYS G+N + +LG D     +  P  ++ L    ++  S G +H A ++  G VFTWG   +G+LG +   + SI  +V  L G  + Q+ CG +HTLA +     ++++G    GQLG+ D  ++  T + I
Sbjct:  151 LALTKNSEIFSWGANTCGQLGLG-DNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPI 344          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Match: SMESG000057228.1 (SMESG000057228.1)

HSP 1 Score: 684.1 bits (1764), Expect = 0.000e+0
Identity = 396/1028 (38.52%), Postives = 584/1028 (56.81%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS-IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESL---PLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKS--ISEVXXXXXXXXXXXXXDI----KNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEG-QNTKKKFSDIIEMKPVFDCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSK---IEFSLFDYPFLFDGITKTNLMKIEAKCLMSEG---------LPCFMAQSS---------FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLE-CYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            CG  HT+  L NG +   G+N   + G    K    +I +    K    + G   +  ++  G+++TWG N+  +LGR    +F  I++VQ L+ + I+QVACG  H LAL+ +S +FSWG N  GQ+G G+    VS P+ + +L  LPIK I  GD  S +LT SG +Y+WG N++GQLG     S E+L   P+ +K ++   I Y+ VG  H A L+ DGGVFT+G GRYGQLGH NFE++  P  VMDL+GS V+Q+ CG   TL Y+  +   Y FG    GQLGI    E   +   ++   + L     SK   ++ ++++   +R+Y GGNHS I  +     K    DD+R WN++    I ++N  + E        +K   IS V  +  +    +   +    KNS F +++  HG++ID      ++   +     ++ L + M +N+     + +NYP +ECLR FLI  +S ++    +   I +P   + +     P   L+ WI  LKPRYFKK   +  N +   ++  E  QN K      I++    + L  ++ INE   +I+ Y  FYIP I +  D+E ++  W    S    + FS   YPF+FD   K+ L+++EA   M            +    AQ S         F I V R+ +L DT+  L +A+Q   KK  +++F  E+A+D+GGV+KE FLLV+ +++ P  GLF+ Y +S++C+F + + + DN+  +  +G+L GLAIYN V+IDLHFPLV+FKKLL E ++LDDL+EL+P LG SLQ +LDY  NDF+D+F     +S E   G    +EL+ +G   PVT  N++ +V  Y+ +IL+KNV   F  F+ GF+    G  LK F+PIELQE+MVG E  +W  L+ +  Y G+YW  HQ+I WFW  F  L+ ++KK+FLR+LTGCDR PI G++D KI IQP N  D + PVAHTCYNLLDLPKY+S+ +L+ KL  AIE+ EGF LV
Sbjct:   53 CGTSHTVMCLCNGTVLCAGDNSLLQFGKKAPKSHFEKISLFKEDKCCYVACGSHFSVALSTNGIIYTWGSNNANQLGRAMRDEFGKIEIVQCLSNYSIIQVACGLGHCLALSIDSILFSWGENKHGQIGNGNTSPFVSVPEIVLSLECLPIKQIACGDLHSSILTTSGSVYTWGDNSHGQLGTGKNGSEEALSSNPIFLKSIKGIQIAYICVGSFHNALLTHDGGVFTFGDGRYGQLGHGNFEDQFSPRKVMDLMGSTVTQLSCGNFFTLVYVTESKRFYGFGKSDEGQLGIGIHTEAVDSPTKLDDFLLDLSIKKNSKDKRKSISDKLNF-RRIYSGGNHSFILLTD---EKYKETDDMRNWNYETLKYIAMINESIIEEFQKPRDNIKDEIISTVYTAMGSLGCLAASFLDKSDKNSHFSMNKVKHGVDIDACHAFYNKMMKTFDESEMEMLRIHMYENLLQLRNFQQNYPGIECLRSFLILLISPMINNVNWYDTITVPTLTAINSFATVPRNYLDAWITKLKPRYFKKIVEMVTNLVKYHVSLLESKQNNKIPDKSQIQLTAALEFLKTIYMINE-KTKILSYTLFYIPTINEKIDIEKNFIDWATASSHYLPVSFSFCSYPFVFDAKAKSKLLQVEAGLFMRNAVLETHTNLIMSILNAQESGIINMETPFFEIGVNRETVLQDTLKALEKASQKEFKKPLKISFSNEEAVDDGGVVKEYFLLVIREIMLPKTGLFKCYNQSKMCYFQQNVKNKDNI--YRCVGQLCGLAIYNGVIIDLHFPLVLFKKLLGEISSLDDLVELDPVLGNSLQQVLDYTGNDFKDVFGFYHDISWEDIEGKSHIHELVTNGKSVPVTNDNKEQFVLDYIHFILDKNVASGFDAFKIGFYLVCVGSVLKLFRPIELQEMMVGCEINEWSELQNNAVYEGDYWKGHQVIIWFWEVFKDLNIEKKKQFLRFLTGCDRAPITGVTDFKIVIQPTNGGDQFYPVAHTCYNLLDLPKYSSKKVLKTKLLAAIEHTEGFTLV 1073          

HSP 2 Score: 105.916 bits (263), Expect = 9.882e-23
Identity = 65/195 (33.33%), Postives = 102/195 (52.31%), Query Frame = 2
Query:  512 IVQVACGHDHTLALTKNSEIFSWGANTCGQLGL---GDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFEN-KSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLG 1084
            +  VACG  HT+    N  +   G N+  Q G      +F+ +S  ++ K         +  G  FS  L+ +G +Y+WGSNN  QLGR +   +  + + V+ L    I+ V+ G  H  ALSID  +F+WG  ++GQ+G+ N     S+P IV+ L    + QI CG  H+ + + ++G+VY +G    GQLG
Sbjct:   48 VKHVACGTSHTVMCLCNGTVLCAGDNSLLQFGKKAPKSHFEKISLFKEDKCC------YVACGSHFSVALSTNGIIYTWGSNNANQLGRAMRDEFGKIEI-VQCLSNYSIIQVACGLGHCLALSIDSILFSWGENKHGQIGNGNTSPFVSVPEIVLSLECLPIKQIACGDLHS-SILTTSGSVYTWGDNSHGQLG 234          
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Match: SMESG000057228.1 (SMESG000057228.1)

HSP 1 Score: 676.011 bits (1743), Expect = 0.000e+0
Identity = 395/1045 (37.80%), Postives = 584/1045 (55.89%), Query Frame = 2
Query:  224 CGFDHTLFLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNAVVTNLGLVFTWGKNSFGELGRDKLSDFS-IKLVQSLTGHFIVQVACGHDHTLALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESL---PLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVPLECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLRLWNWKHPTNITVMNVDVNEPIYTSISTMKS--ISEVXXXXXXXXXXXXXDI----KNSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQYNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIALNKWIGNLKPRYFKKFCMVFINAINNEINGFEG-QNTKKKFSDIIEMKPVFDCLCKLHQINE-----------------DHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSK---IEFSLFDYPFLFDGITKTNLMKIEAKCLMSEG---------LPCFMAQSS---------FHITVRRDNLLGDTISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYGLFEMYPESRLCWFNKMIFD-DNLPQFNAIGRLFGLAIYNNVMIDLHFPLVMFKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLE-CYGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGFHFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIXXXXXXXXXXXXDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLPVAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV 3205
            CG  HT+  L NG +   G+N   + G    K    +I +    K    + G   +  ++  G+++TWG N+  +LGR    +F  I++VQ L+ + I+QVACG  H LAL+ +S +FSWG N  GQ+G G+    VS P+ + +L  LPIK I  GD  S +LT SG +Y+WG N++GQLG     S E+L   P+ +K ++   I Y+ VG  H A L+ DGGVFT+G GRYGQLGH NFE++  P  VMDL+GS V+Q+ CG   TL Y+  +   Y FG    GQLGI    E   +   ++   + L     SK   ++ ++++   +R+Y GGNHS I  +     K    DD+R WN++    I ++N  + E        +K   IS V  +  +    +   +    KNS F +++  HG++ID      ++   +     ++ L + M +N+     + +NYP +ECLR FLI  +S ++    +   I +P   + +     P   L+ WI  LKPRYFKK   +  N +   ++  E  QN K      I++    + L  ++ IN                  +  +I+ Y  FYIP I +  D+E ++  W    S    + FS   YPF+FD   K+ L+++EA   M            +    AQ S         F I V R+ +L DT+  L +A+Q   KK  +++F  E+A+D+GGV+KE FLLV+ +++ P  GLF+ Y +S++C+F + + + DN+  +  +G+L GLAIYN V+IDLHFPLV+FKKLL E ++LDDL+EL+P LG SLQ +LDY  NDF+D+F     +S E   G    +EL+ +G   PVT  N++ +V  Y+ +IL+KNV   F  F+ GF+    G  LK F+PIELQE+MVG E  +W  L+ +  Y G+YW  HQ+I WFW  F  L+ ++KK+FLR+LTGCDR PI G++D KI IQP N  D + PVAHTCYNLLDLPKY+S+ +L+ KL  AIE+ EGF LV
Sbjct:   53 CGTSHTVMCLCNGTVLCAGDNSLLQFGKKAPKSHFEKISLFKEDKCCYVACGSHFSVALSTNGIIYTWGSNNANQLGRAMRDEFGKIEIVQCLSNYSIIQVACGLGHCLALSIDSILFSWGENKHGQIGNGNTSPFVSVPEIVLSLECLPIKQIACGDLHSSILTTSGSVYTWGDNSHGQLGTGKNGSEEALSSNPIFLKSIKGIQIAYICVGSFHNALLTHDGGVFTFGDGRYGQLGHGNFEDQFSPRKVMDLMGSTVTQLSCGNFFTLVYVTESKRFYGFGKSDEGQLGIGIHTEAVDSPTKLDDFLLDLSIKKNSKDKRKSISDKLNF-RRIYSGGNHSFILLTD---EKYKETDDMRNWNYETLKYIAMINESIIEEFQKPRDNIKDEIISTVYTAMGSLGCLAASFLDKSDKNSHFSMNKVKHGVDIDACHAFYNKMMKTFDESEMEMLRIHMYENLLQLRNFQQNYPGIECLRSFLILLISPMINNVNWYDTITVPTLTAINSFATVPRNYLDAWITKLKPRYFKKIVEMVTNLVKYHVSLLESKQNNKIPDKSQIQLTAALEFLKTIYMINSTNRCLNSKRSNIPKNINEKTKILSYTLFYIPTINEKIDIEKNFIDWATASSHYLPVSFSFCSYPFVFDAKAKSKLLQVEAGLFMRNAVLETHTNLIMSILNAQESGIINMETPFFEIGVNRETVLQDTLKALEKASQKEFKKPLKISFSNEEAVDDGGVVKEYFLLVIREIMLPKTGLFKCYNQSKMCYFQQNVKNKDNI--YRCVGQLCGLAIYNGVIIDLHFPLVLFKKLLGEISSLDDLVELDPVLGNSLQQVLDYTGNDFKDVFGFYHDISWEDIEGKSHIHELVTNGKSVPVTNDNKEQFVLDYIHFILDKNVASGFDAFKIGFYLVCVGSVLKLFRPIELQEMMVGCEINEWSELQNNAVYEGDYWKGHQVIIWFWEVFKDLNIEKKKQFLRFLTGCDRAPITGVTDFKIVIQPTNGGDQFYPVAHTCYNLLDLPKYSSKKVLKTKLLAAIEHTEGFTLV 1091          

HSP 2 Score: 105.916 bits (263), Expect = 9.586e-23
Identity = 65/195 (33.33%), Postives = 102/195 (52.31%), Query Frame = 2
Query:  512 IVQVACGHDHTLALTKNSEIFSWGANTCGQLGL---GDNFDMVSTPQQIKNLSNLPIKSITAGDKFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVSVGQNHVAALSIDGGVFTWGHGRYGQLGHNNFEN-KSIPCIVMDLLGSKVSQIECGMNHTLAYMVSTGTVYAFGLGKFGQLG 1084
            +  VACG  HT+    N  +   G N+  Q G      +F+ +S  ++ K         +  G  FS  L+ +G +Y+WGSNN  QLGR +   +  + + V+ L    I+ V+ G  H  ALSID  +F+WG  ++GQ+G+ N     S+P IV+ L    + QI CG  H+ + + ++G+VY +G    GQLG
Sbjct:   48 VKHVACGTSHTVMCLCNGTVLCAGDNSLLQFGKKAPKSHFEKISLFKEDKCC------YVACGSHFSVALSTNGIIYTWGSNNANQLGRAMRDEFGKIEI-VQCLSNYSIIQVACGLGHCLALSIDSILFSWGENKHGQIGNGNTSPFVSVPEIVLSLECLPIKQIACGDLHS-SILTTSGSVYTWGDNSHGQLG 234          
The following BLAST results are available for this feature:
BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HERC48.627e-1836.85HECT and RLD domain containing E3 ubiquitin protei... [more]
HERC48.814e-1836.67HECT and RLD domain containing E3 ubiquitin protei... [more]
AC098582.10.000e+035.73HECT and RLD domain containing E3 ubiquitin protei... [more]
HERC30.000e+035.46HECT and RLD domain containing E3 ubiquitin protei... [more]
HERC30.000e+035.46HECT and RLD domain containing E3 ubiquitin protei... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
herc-12.666e-14731.95HECT and RCC domain E3 ubiquitin ligase [Source:U... [more]
herc-12.666e-14731.95HECT and RCC domain E3 ubiquitin ligase [Source:U... [more]
herc-15.197e-10034.98HECT and RCC domain E3 ubiquitin ligase [Source:U... [more]
herc-18.178e-10035.19HECT and RCC domain E3 ubiquitin ligase [Source:U... [more]
herc-17.034e-9938.48HECT and RCC domain E3 ubiquitin ligase [Source:U... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Herc41.961e-2833.86gene:FBgn0035207 transcript:FBtr0072670[more]
Herc41.961e-2833.86gene:FBgn0035207 transcript:FBtr0072671[more]
Herc41.186e-2734.02gene:FBgn0035207 transcript:FBtr0310555[more]
Ube3a4.065e-6137.68gene:FBgn0061469 transcript:FBtr0076186[more]
HERC27.658e-4135.90gene:FBgn0031107 transcript:FBtr0301344[more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
herc40.000e+035.77HECT and RLD domain containing E3 ubiquitin protei... [more]
herc30.000e+033.64HECT and RLD domain containing E3 ubiquitin protei... [more]
si:ch73-190m4.13.646e-11130.10si:ch73-190m4.1 [Source:ZFIN;Acc:ZDB-GENE-090311-5... [more]
slc47a2.25.881e-10131.38solute carrier family 47 member 2.2 [Source:ZFIN;A... [more]
si:ch211-281g13.58.664e-9931.73si:ch211-281g13.5 [Source:ZFIN;Acc:ZDB-GENE-090311... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prxl2b0.000e+035.90peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-... [more]
prxl2b9.494e-636.00peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-... [more]
prxl2b0.000e+035.49peroxiredoxin like 2B [Source:Xenbase;Acc:XB-GENE-... [more]
ENSXETT00000039332.10.000e+034.94HECT and RLD domain containing E3 ubiquitin protei... [more]
ENSXETT00000027632.10.000e+034.68HECT and RLD domain containing E3 ubiquitin protei... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Herc43.129e-1836.39hect domain and RLD 4 [Source:MGI Symbol;Acc:MGI:1... [more]
Herc43.511e-1836.12hect domain and RLD 4 [Source:MGI Symbol;Acc:MGI:1... [more]
Herc30.000e+035.65hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Herc35.609e-15233.85hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Herc61.894e-11628.92hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6PAV2|HERC4_MOUSE2.456e-1736.12Probable E3 ubiquitin-protein ligase HERC4 OS=Mus ... [more]
sp|Q5PQN1|HERC4_RAT2.125e-1736.31Probable E3 ubiquitin-protein ligase HERC4 OS=Ratt... [more]
sp|Q5GLZ8|HERC4_HUMAN4.233e-1736.67Probable E3 ubiquitin-protein ligase HERC4 OS=Homo... [more]
sp|Q15034|HERC3_HUMAN0.000e+035.46Probable E3 ubiquitin-protein ligase HERC3 OS=Homo... [more]
sp|Q9UII4|HERC5_HUMAN3.214e-12729.91E3 ISG15--protein ligase HERC5 OS=Homo sapiens OX=... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A094ZME99.347e-1337.68Putative E3 ubiquitin-protein ligase HERC4 OS=Schi... [more]
A0A5K4EPN54.804e-1437.01Putative hect E3 ubiquitin ligase OS=Schistosoma m... [more]
G4VNS73.794e-1237.08Putative hect E3 ubiquitin ligase OS=Schistosoma m... [more]
A0A4S2LMJ30.000e+036.34HECT domain-containing protein OS=Opisthorchis fel... [more]
A0A4Z2CNU82.322e-1236.48Putative E3 ubiquitin-protein ligase HERC4 OS=Schi... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
herc40.000e+035.76HECT and RLD domain containing E3 ubiquitin protei... [more]
herc40.000e+035.35HECT and RLD domain containing E3 ubiquitin protei... [more]
herc38.554e-3633.89HECT and RLD domain containing E3 ubiquitin protei... [more]
herc30.000e+033.06HECT and RLD domain containing E3 ubiquitin protei... [more]
herc32.873e-9335.86HECT and RLD domain containing E3 ubiquitin protei... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
herc41.170e-15736.30HECT and RLD domain containing E3 ubiquitin protei... [more]
ube3a1.428e-7037.13ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-... [more]
nedd4a5.999e-4030.98NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A... [more]
ube3c3.818e-3730.16ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-... [more]
ENSPMAT00000001275.11.135e-3432.91pep scaffold:Pmarinus_7.0:GL476529:184068:212443:-... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
HUL41.926e-4732.09Protein with similarity to hect domain E3 ubiquiti... [more]
RSP53.957e-4030.62NEDD4 family E3 ubiquitin ligase; regulates proces... [more]
TOM19.304e-3831.94E3 ubiquitin ligase of the hect-domain class; has ... [more]
HUL57.866e-2630.17Multiubiquitin chain assembly factor (E4); proteas... [more]
SRM19.578e-2326.56Nucleotide exchange factor for Gsp1p; localizes to... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO345920.000e+036.49Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO404623.847e-7340.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403023.508e-7233.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO341262.322e-6635.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493272.312e-4431.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
herc40.000e+036.08HECT and RLD domain containing E3 ubiquitin protei... [more]
herc40.000e+036.38HECT and RLD domain containing E3 ubiquitin protei... [more]
herc30.000e+034.05HECT and RLD domain containing E3 ubiquitin protei... [more]
herc31.128e-14832.51HECT and RLD domain containing E3 ubiquitin protei... [more]
ENSORLT00000015298.29.764e-9028.11probable E3 ubiquitin-protein ligase HERC4 [Source... [more]
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BLAST of HECT and RLD domain containing E3 ubiquitin protein ligase 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000033113.10.000e+099.72SMESG000033113.1[more]
SMESG000033113.10.000e+099.62SMESG000033113.1[more]
SMESG000033113.11.004e-1899.71SMESG000033113.1[more]
SMESG000057228.19.882e-2338.52SMESG000057228.1[more]
SMESG000057228.19.586e-2337.80SMESG000057228.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005288 ID=SMED30005288|Name=HECT and RLD domain containing E3 ubiquitin protein ligase 4|organism=Schmidtea mediterranea sexual|type=transcript|length=3448bp
ATTTGTTTAAATTTAAAACTTTTTCTTATTTTACATCTATTTTAGGTTAA
CTTTATATTTTAAACTAAACTTTGAATTTATCATTATTTTAAAAATGATT
TCGATATTTTCCTTCGGTGCAGCAAGCTACGGGCAATTAGGAATTGATCC
TCGAAATAAAGATTATTATAGTTATCCACAGAAAATTGATAAAATTTCTT
CTAGTGATATTGAAAAGATTTCTTGTGGATTTGATCACACATTGTTTTTA
CTTAAAAACGGAAAACTTTATAGCTGTGGAAATAACGAATTTAAAAAACT
AGGCCATGATTGTAATAAAGTCAAACCTAATCAAATACAAATGTTGGATG
CTCACAAATTAATCGATGCAAGTGCTGGCTATGATCATAATGCAGTAGTT
ACTAATCTAGGGCTAGTTTTTACATGGGGCAAGAATTCATTTGGTGAATT
AGGAAGAGATAAATTGTCTGATTTCAGTATTAAACTTGTCCAAAGTTTAA
CTGGTCATTTTATCGTTCAGGTTGCATGTGGACATGATCATACTTTGGCC
TTAACTAAGAATTCCGAAATATTTTCGTGGGGTGCGAATACTTGTGGACA
ACTTGGTCTTGGTGATAATTTTGATATGGTATCTACACCACAACAAATTA
AAAATTTATCTAATTTACCAATAAAATCTATTACAGCTGGTGACAAATTT
TCATTTGTATTAACTCCTTCAGGATTTTTGTATTCTTGGGGTTCTAATAA
TTATGGTCAGCTTGGCAGAGATTTAACCACTTCATATGAAAGTTTACCAC
TAATGGTTAAGCATTTAAGGAAACAGCCAATAGTATATGTAAGTGTCGGC
CAAAATCATGTTGCTGCGTTATCAATTGATGGTGGAGTTTTTACTTGGGG
TCATGGAAGATATGGACAATTAGGACATAATAATTTTGAAAATAAATCAA
TTCCTTGCATTGTGATGGATTTATTAGGAAGTAAAGTTAGTCAAATTGAG
TGCGGTATGAATCATACTTTGGCATACATGGTTTCAACAGGAACTGTTTA
TGCATTTGGTCTTGGTAAATTTGGTCAACTTGGAATATGCGATACTGTTG
AAATATGTCATACTGCAAAACCGATAAACGGGCATTGGGTACCTTTAGAG
TGTAACAACCAATCAAAAATATCTGGTGAAACGACAGCTGAACAGATGTA
CATTGTTAAAAGATTATACGGAGGTGGGAATCATTCAATCATAACAGCCA
GTTCTCTAGATTGTGGAAAGAAGGTTTATCCTGATGATTTAAGACTTTGG
AATTGGAAACACCCAACAAATATAACAGTGATGAATGTAGATGTAAATGA
ACCAATATATACATCCATTTCAACTATGAAATCAATTTCAGAAGTTTTAT
TTTCTTCTTTGGCATGTTTGTCATCAAGTTTCTTGGATATAAAAAATAGT
GTATTCCACATTAGTCAAACAAATCATGGTCTCAATATTGATTTAACTTT
TAATATAATGTCTCAATTTTTCTCGTCTCAATCATCAGATTATTTACAAA
CACTAGCTGTAAGGATGAAAGATAACATTTTCAGCCAAATTCAATATAAT
AGGAATTATCCAAGCTTGGAATGTTTAAGATTTTTCCTTATCTTTGCCGT
GTCAACAATTTTAGAAATCTCAGAGTTCTGCAAAGTTATTCTCATTCCAT
TTTCTGTTTCATTTTCTATTATACACGAAACCCCTTCAATAGCTCTCAAT
AAATGGATTGGGAATCTAAAACCAAGGTACTTTAAGAAATTTTGCATGGT
TTTTATAAATGCCATAAATAATGAAATCAATGGTTTCGAAGGTCAAAATA
CAAAGAAAAAATTCAGTGATATTATTGAAATGAAGCCAGTTTTTGATTGC
TTGTGTAAATTACACCAGATTAATGAAGATCACAATAGAATAATTCATTA
TAACACATTCTATATACCAAAAATTCCGAAAGTGTTTGACCTGGAATATT
CTTATGAGTTGTGGTTGAGAAATGTCTCAAAAATTGAATTTTCATTATTC
GACTATCCTTTTTTATTCGACGGTATTACCAAAACCAATTTAATGAAAAT
TGAGGCTAAATGCTTGATGTCAGAAGGTTTACCATGCTTTATGGCACAAA
GCAGTTTTCATATTACTGTACGCAGAGATAATTTATTAGGTGATACTATC
AGTCAATTGCACCGAGCTACTCAATGTCACCTTAAAAAGTCATTTAGAGT
TAATTTTATGGGTGAAGATGCTTTAGATGAAGGTGGAGTAATGAAGGAAT
TATTTTTACTTGTCGTACCTCAAGTTTTAAATCCAGATTATGGTCTTTTT
GAAATGTATCCAGAATCAAGATTGTGTTGGTTTAACAAAATGATATTTGA
TGATAATCTACCACAGTTTAATGCAATCGGTCGATTGTTTGGCCTAGCAA
TTTACAACAATGTTATGATTGATCTTCACTTTCCACTTGTGATGTTCAAA
AAGTTGCTCAATGAAAAGGCTAATCTAGATGATTTAATCGAGCTCAATCC
GACTTTGGGAAAATCATTACAGGTTTTACTTGATTACGATCAAAATGATT
TTGAAGATATATTCATGCTTAATTTTATAGTTTCTCTTGAATGTTATGGT
AATAAAATAGAATATGAATTGATTCGAGATGGTTACGATAAACCTGTTAC
TCTTAGCAACCGTCAGACATATGTTGATCTATATGTTGATTACATTCTTA
ATAAAAATGTTGAACAACCATTTAAATATTTTCAAGAGGGATTTCATTTT
ACCATGCAAGGAAAGTGTTTAAAATTTTTCAAACCTATTGAACTACAAGA
GTTGATGGTAGGTTCAGAGAGTTATGATTGGTTACTTTTACGCAAATCAT
GTGAATATCTTGGTGAATATTGGAATAATCATCAAATCATAAACTGGTTC
TGGAATTCGTTCAGTTCATTAAGCTTCGATGAAAAGAAGAAATTTTTAAG
ATATTTAACCGGATGTGATCGAGTTCCTATCAATGGAATGTCAGATATAA
AAATCAAAATCCAACCGGTAAATGTTGACGACAATTACCTACCTGTTGCG
CATACATGCTACAATCTTCTTGATTTGCCAAAATATACTTCAGAAAGTAT
CTTGCGTGATAAACTAAAAATCGCTATTGAAAATAATGAAGGATTTGCAT
TAGTTTAAATTGAACACTTTGTATTAAATAAAAAATAGATTTTTTTAATT
TTAATTTCTTTTGTGAAACACTAAATATTGCCTTATTGCTAAAATTTTCG
GTTTTCATGATTTTTGTTATTTCTTAAGGGTATACAGATGTTATTTTATA
ATCACCATTTGAAGTGAAATTACGAATAGTGACTATTTTTGTTGGGTATT
ACATTTTAATAAGTAAAATTTAATGTAAAAATGTGATTTATATTTAAA
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protein sequence of SMED30005288-orf-1

>SMED30005288-orf-1 ID=SMED30005288-orf-1|Name=SMED30005288-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1038bp
MISIFSFGAASYGQLGIDPRNKDYYSYPQKIDKISSSDIEKISCGFDHTL
FLLKNGKLYSCGNNEFKKLGHDCNKVKPNQIQMLDAHKLIDASAGYDHNA
VVTNLGLVFTWGKNSFGELGRDKLSDFSIKLVQSLTGHFIVQVACGHDHT
LALTKNSEIFSWGANTCGQLGLGDNFDMVSTPQQIKNLSNLPIKSITAGD
KFSFVLTPSGFLYSWGSNNYGQLGRDLTTSYESLPLMVKHLRKQPIVYVS
VGQNHVAALSIDGGVFTWGHGRYGQLGHNNFENKSIPCIVMDLLGSKVSQ
IECGMNHTLAYMVSTGTVYAFGLGKFGQLGICDTVEICHTAKPINGHWVP
LECNNQSKISGETTAEQMYIVKRLYGGGNHSIITASSLDCGKKVYPDDLR
LWNWKHPTNITVMNVDVNEPIYTSISTMKSISEVLFSSLACLSSSFLDIK
NSVFHISQTNHGLNIDLTFNIMSQFFSSQSSDYLQTLAVRMKDNIFSQIQ
YNRNYPSLECLRFFLIFAVSTILEISEFCKVILIPFSVSFSIIHETPSIA
LNKWIGNLKPRYFKKFCMVFINAINNEINGFEGQNTKKKFSDIIEMKPVF
DCLCKLHQINEDHNRIIHYNTFYIPKIPKVFDLEYSYELWLRNVSKIEFS
LFDYPFLFDGITKTNLMKIEAKCLMSEGLPCFMAQSSFHITVRRDNLLGD
TISQLHRATQCHLKKSFRVNFMGEDALDEGGVMKELFLLVVPQVLNPDYG
LFEMYPESRLCWFNKMIFDDNLPQFNAIGRLFGLAIYNNVMIDLHFPLVM
FKKLLNEKANLDDLIELNPTLGKSLQVLLDYDQNDFEDIFMLNFIVSLEC
YGNKIEYELIRDGYDKPVTLSNRQTYVDLYVDYILNKNVEQPFKYFQEGF
HFTMQGKCLKFFKPIELQELMVGSESYDWLLLRKSCEYLGEYWNNHQIIN
WFWNSFSSLSFDEKKKFLRYLTGCDRVPINGMSDIKIKIQPVNVDDNYLP
VAHTCYNLLDLPKYTSESILRDKLKIAIENNEGFALV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0001650fibrillar center
GO:0005829cytosol
Vocabulary: biological process
TermDefinition
GO:0007283spermatogenesis
GO:0016567protein ubiquitination
Vocabulary: INTERPRO
TermDefinition
IPR035983Hect_E3_ubiquitin_ligase
IPR000408Reg_chr_condens
IPR000569HECT_dom
IPR009091RCC1/BLIP-II
Vocabulary: molecular function
TermDefinition
GO:0004842ubiquitin-protein transferase activity
GO:0016740transferase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000408Regulator of chromosome condensation, RCC1PRINTSPR00633RCCNDNSATIONcoord: 39..52
score: 33.33
coord: 3..19
score: 31.37
coord: 159..173
score: 35.56
coord: 58..74
score: 37.25
coord: 252..270
score: 32.46
coord: 311..332
score: 31.82
coord: 143..159
score: 38.24
IPR000408Regulator of chromosome condensation, RCC1PFAMPF00415RCC1coord: 210..259
e-value: 3.1E-11
score: 43.7
coord: 55..102
e-value: 1.3E-7
score: 32.1
coord: 4..52
e-value: 6.9E-9
score: 36.2
coord: 158..206
e-value: 1.2E-11
score: 45.0
coord: 106..153
e-value: 1.1E-9
score: 38.8
coord: 262..310
e-value: 3.8E-14
score: 53.1
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS00626RCC1_2coord: 143..153
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS00626RCC1_2coord: 42..52
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 2..55
score: 13.439
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 106..156
score: 14.584
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 210..262
score: 15.71
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 56..105
score: 10.444
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 263..314
score: 14.665
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 157..209
score: 14.886
IPR000408Regulator of chromosome condensation, RCC1PROSITEPS50012RCC1_3coord: 316..387
score: 10.102
IPR000569HECT domainSMARTSM00119hect_3coord: 707..1037
e-value: 8.3E-103
score: 357.5
IPR000569HECT domainPFAMPF00632HECTcoord: 739..1036
e-value: 1.4E-83
score: 280.9
IPR000569HECT domainPROSITEPS50237HECTcoord: 709..1037
score: 85.229
IPR000569HECT domainCDDcd00078HECTccoord: 688..1034
e-value: 4.81726E-120
score: 369.972
NoneNo IPR availableGENE3DG3DSA:3.90.1750.10coord: 690..921
e-value: 6.4E-71
score: 240.6
NoneNo IPR availableGENE3DG3DSA:3.30.2160.10coord: 808..888
e-value: 6.4E-71
score: 240.6
NoneNo IPR availableGENE3DG3DSA:3.30.2410.10coord: 923..1037
e-value: 2.5E-35
score: 123.0
NoneNo IPR availablePANTHERPTHR45622FAMILY NOT NAMEDcoord: 35..1037
NoneNo IPR availablePANTHERPTHR45622:SF13LD13353Pcoord: 35..1037
IPR009091Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IIGENE3DG3DSA:2.130.10.30coord: 76..229
e-value: 1.6E-48
score: 167.4
coord: 3..75
e-value: 4.8E-16
score: 60.3
coord: 230..395
e-value: 1.1E-29
score: 105.2
IPR009091Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IISUPERFAMILYSSF50985RCC1/BLIP-IIcoord: 238..406
IPR009091Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IISUPERFAMILYSSF50985RCC1/BLIP-IIcoord: 4..290
IPR035983HECT, E3 ligase catalytic domainSUPERFAMILYSSF56204Hect, E3 ligase catalytic domaincoord: 682..1031