Homeobox protein

Overview
NameHomeobox protein
Smed IDSMED30005185
Length (bp)1544
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Homeobox protein (SMED30005185) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox protein (SMED30005185) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeobox protein (SMED30005185) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeobox protein (SMED30005185) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30005185

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30005185h1SMcG0021724 dd_Smed_v4_13898_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30005185h1SMcG0021724 dd_Smed_v4_13898_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30005185h1SMcG0021724 dd_Smed_v4_13898_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30005185h1SMcG0021724 dd_Smed_v4_13898_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
prepharyngeal regionSMED30005185h1SMcG0021724 dd_Smed_v6_13898_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
central nervous systemSMED30005185h1SMcG0021724 KJ934806smed_ncbi_20240424PMID:25254346
Scimone et al., 2014		whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30005185h1SMcG0021724 OX_Smed_1.0.06987ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
neuronSMED30005185h1SMcG0021724 dd_Smed_v6_13898_0_1dd_Smed_v6PMID:27864883
Currie et al., 2016		whole organism asexual adult fluorescence in situ hybridization evidence
cholinergic neuronSMED30005185h1SMcG0021724 dd_Smed_v6_13898_0_1dd_Smed_v6PMID:27864883
Currie et al., 2016		whole organism asexual adult fluorescence in situ hybridization evidence
GABAergic neuronSMED30005185h1SMcG0021724 dd_Smed_v6_13898_0_1dd_Smed_v6PMID:27864883
Currie et al., 2016		whole organism asexual adult fluorescence in situ hybridization evidence
octopaminergic neuronSMED30005185h1SMcG0021724 dd_Smed_v6_13898_0_1dd_Smed_v6PMID:27864883
Currie et al., 2016		whole organism asexual adult fluorescence in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Homeobox protein vs. Ensembl Human
Match: NKX2-4 (NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837])

HSP 1 Score: 128.257 bits (321), Expect = 3.318e-32
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  189 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 259
[Close]
BLAST of Homeobox protein vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 126.331 bits (316), Expect = 1.970e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 126.331 bits (316), Expect = 1.970e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 126.331 bits (316), Expect = 1.970e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 126.331 bits (316), Expect = 3.032e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  191 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 252
[Close]
BLAST of Homeobox protein vs. Ensembl Celegans
Match: ceh-24 (Homeobox protein ceh-24 [Source:UniProtKB/Swiss-Prot;Acc:Q9NLC2])

HSP 1 Score: 120.168 bits (300), Expect = 3.266e-30
Identity = 54/66 (81.82%), Postives = 60/66 (90.91%), Query Frame = 3 
Query:  690 SHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            S SQRR+RR+LFSQAQVYELERRFKQ KYL+APERE LA+ I LTPTQVKIWFQNHRYKCKR +K+
Sbjct:  146 SMSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRLTPTQVKIWFQNHRYKCKRQEKE 211
[Close]
BLAST of Homeobox protein vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 98.9821 bits (245), Expect = 1.540e-23
Identity = 43/57 (75.44%), Postives = 48/57 (84.21%), Query Frame = 3 
Query:  717 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+S  D
Sbjct:   63 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTD 119
[Close]
BLAST of Homeobox protein vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 99.3673 bits (246), Expect = 2.924e-23
Identity = 43/57 (75.44%), Postives = 48/57 (84.21%), Query Frame = 3 
Query:  717 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+S  D
Sbjct:  108 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTD 164
[Close]
BLAST of Homeobox protein vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 98.9821 bits (245), Expect = 6.304e-23
Identity = 43/57 (75.44%), Postives = 48/57 (84.21%), Query Frame = 3 
Query:  717 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+S  D
Sbjct:  131 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTD 187
[Close]
BLAST of Homeobox protein vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 99.3673 bits (246), Expect = 1.108e-22
Identity = 43/57 (75.44%), Postives = 48/57 (84.21%), Query Frame = 3 
Query:  717 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+S  D
Sbjct:  194 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTD 250
[Close]
BLAST of Homeobox protein vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0339923)

HSP 1 Score: 131.339 bits (329), Expect = 3.980e-34
Identity = 73/135 (54.07%), Postives = 89/135 (65.93%), Query Frame = 3 
Query:  510 GGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            G    D R A+S+L+  S ++SGT  +  N MS     S  D     F    P+        +QRR+RR+LF+QAQVYELERRFKQQ+YLSAPEREHLASLI+LTPTQVKIWFQNHRYKCKR  K+    +Q + 
Sbjct:   43 GSTANDPRFAISRLM--SSSASGTMSHMGN-MSGLAACSVSDSKPLQF----PL--------AQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQH 162
[Close]
BLAST of Homeobox protein vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0113751)

HSP 1 Score: 132.109 bits (331), Expect = 4.281e-33
Identity = 73/134 (54.48%), Postives = 89/134 (66.42%), Query Frame = 3 
Query:  510 GGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKR 911
            G    D R A+S+L+  S ++SGT  +  N MS     S  D     F    P+        +QRR+RR+LF+QAQVYELERRFKQQ+YLSAPEREHLASLI+LTPTQVKIWFQNHRYKCKR  K+    +Q +
Sbjct:  204 GSTANDPRFAISRLM--SSSASGTMSHMGN-MSGLAACSVSDSKPLQF----PL--------AQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQ 322
[Close]
BLAST of Homeobox protein vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0070110)

HSP 1 Score: 118.627 bits (296), Expect = 5.956e-28
Identity = 51/78 (65.38%), Postives = 64/78 (82.05%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMST 932
            ++R+RR+LF++AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR+Q +   +     + G +T
Sbjct:  544 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHAT 621
[Close]
BLAST of Homeobox protein vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0110929)

HSP 1 Score: 117.857 bits (294), Expect = 6.780e-28
Identity = 51/78 (65.38%), Postives = 64/78 (82.05%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMST 932
            ++R+RR+LF++AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR+Q +   +     + G +T
Sbjct:  398 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHAT 475
[Close]
BLAST of Homeobox protein vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0113752)

HSP 1 Score: 93.2041 bits (230), Expect = 4.209e-20
Identity = 57/108 (52.78%), Postives = 70/108 (64.81%), Query Frame = 3 
Query:  510 GGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQ 833
            G    D R A+S+L+  S ++SGT  +  N MS     S  D     F    P+        +QRR+RR+LF+QAQVYELERRFKQQ+YLSAPEREHLASLI+LTPTQ
Sbjct:  204 GSTANDPRFAISRLM--SSSASGTMSHMGN-MSGLAACSVSDSKPLQF----PL--------AQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQ 296
[Close]
BLAST of Homeobox protein vs. Ensembl Zebrafish
Match: nkx2.1 (NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1])

HSP 1 Score: 131.724 bits (330), Expect = 1.022e-33
Identity = 75/151 (49.67%), Postives = 94/151 (62.25%), Query Frame = 3 
Query:  474 STNPTNWCCNMSGGINTDTR-SAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITG 923
            ST  T+W      G N D R S +S+ +G   +SSG      + +S           +++  G  P+      + + RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    QQ ++  G
Sbjct:  105 STTATSWY-----GTNPDPRFSTISRFMG---SSSGMNMGSMSTLSSL---------ADVGKGMGPL------TSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKVSQQQMQQDNG 232
[Close]
BLAST of Homeobox protein vs. Ensembl Zebrafish
Match: nkx2.4a (NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6336])

HSP 1 Score: 130.568 bits (327), Expect = 1.731e-33
Identity = 66/106 (62.26%), Postives = 76/106 (71.70%), Query Frame = 3 
Query:  618 PSSRYDRSSNLFSGNSPINGMLYQSHS-------QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            P  RY  S N+ +G   + GM   + S        RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  117 PDPRYSTSMNM-TGMGTLTGMADTTKSIPPLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 221
[Close]
BLAST of Homeobox protein vs. Ensembl Zebrafish
Match: nkx2.4b (NK2 homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-000830-1])

HSP 1 Score: 127.872 bits (320), Expect = 9.367e-33
Identity = 57/68 (83.82%), Postives = 61/68 (89.71%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQ 905
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    QQ
Sbjct:  147 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKREAKDKASQQQ 214
[Close]
BLAST of Homeobox protein vs. Ensembl Zebrafish
Match: nkx2.4a (NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6336])

HSP 1 Score: 127.872 bits (320), Expect = 2.062e-32
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  160 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 230
[Close]
BLAST of Homeobox protein vs. Ensembl Zebrafish
Match: nkx2.2a (NK2 homeobox 2a [Source:NCBI gene;Acc:30697])

HSP 1 Score: 117.472 bits (293), Expect = 2.646e-29
Identity = 54/83 (65.06%), Postives = 63/83 (75.90%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPA 947
            ++R+RR+LFS+AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR+          R   GM   H P+
Sbjct:  128 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRA----------RAEKGMEVTHLPS 200
[Close]
BLAST of Homeobox protein vs. Ensembl Xenopus
Match: trpc3 (transient receptor potential cation channel, subfamily C, member 3 [Source:Xenbase;Acc:XB-GENE-1014039])

HSP 1 Score: 130.568 bits (327), Expect = 2.812e-33
Identity = 75/141 (53.19%), Postives = 89/141 (63.12%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADS-----VTSADHCDNRHNVCN----LFQNQQSKTSGLSASPPIMKISENIPDNSLSQV 1097
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD +  QQ ++ + +    SP        V     C N  N       + Q Q   T GLS+S  + +  +N    SLSQ 
Sbjct:  160 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD-KVTQQLQQESNLCQQQSPRRVAVPVLVKDGKPCQNSSNTSTPNQQVTQQQSGATGGLSSSNAVHQ-HQNQQVGSLSQA 298
[Close]
BLAST of Homeobox protein vs. Ensembl Xenopus
Match: fam221a (family with sequence similarity 221 member A [Source:Xenbase;Acc:XB-GENE-1000335])

HSP 1 Score: 129.028 bits (323), Expect = 1.354e-32
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    QQ ++
Sbjct:  162 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQMQQ 232
[Close]
BLAST of Homeobox protein vs. Ensembl Xenopus
Match: NKX2-2 (NK2 homeobox 2 [Source:NCBI gene;Acc:100038077])

HSP 1 Score: 115.161 bits (287), Expect = 2.414e-28
Identity = 49/63 (77.78%), Postives = 59/63 (93.65%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            ++R+RR+LFS+AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR++ +
Sbjct:  126 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAE 188
[Close]
BLAST of Homeobox protein vs. Ensembl Xenopus
Match: ENSXETT00000008392.1 (homeobox protein Nkx-2.1-like [Source:NCBI gene;Acc:100485697])

HSP 1 Score: 109.768 bits (273), Expect = 1.990e-26
Identity = 48/69 (69.57%), Postives = 58/69 (84.06%), Query Frame = 3 
Query:  681 LYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            LY  H+ +R+RR+LFSQAQVYELE+RF+ QKYL+APERE LA  I+LTP QVKIWFQNHRYK KR  ++
Sbjct:  114 LYLQHTSKRKRRVLFSQAQVYELEKRFEHQKYLTAPEREQLAKHIHLTPNQVKIWFQNHRYKMKRQARN 182
[Close]
BLAST of Homeobox protein vs. Ensembl Xenopus
Match: mtm1 (myotubularin 1 [Source:Xenbase;Acc:XB-GENE-1002030])

HSP 1 Score: 107.457 bits (267), Expect = 1.000e-25
Identity = 48/65 (73.85%), Postives = 55/65 (84.62%), Query Frame = 3 
Query:  693 HSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            H QRR+ R+LFSQ QV+ELERRFKQQ+YLSAPERE LA  + LT TQVKIWFQN RYKCKR ++D
Sbjct:   91 HRQRRKPRVLFSQMQVFELERRFKQQRYLSAPEREQLALALKLTSTQVKIWFQNRRYKCKRQKQD 155
[Close]
BLAST of Homeobox protein vs. Ensembl Mouse
Match: Nkx2-4 (NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349])

HSP 1 Score: 130.183 bits (326), Expect = 4.344e-33
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  188 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 258
[Close]
BLAST of Homeobox protein vs. Ensembl Mouse
Match: Nkx2-1 (NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067])

HSP 1 Score: 125.946 bits (315), Expect = 1.744e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. Ensembl Mouse
Match: Nkx2-1 (NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067])

HSP 1 Score: 125.946 bits (315), Expect = 1.744e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 117.857 bits (294), Expect = 1.125e-29
Identity = 59/104 (56.73%), Postives = 71/104 (68.27%), Query Frame = 3 
Query:  696 SQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCNLFQ 1007
             ++R+RR+LFS+AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR++   EK  Q R +        P  S   +D    +  V  L Q
Sbjct:  126 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRAR--AEKAFQNRRMDARIEAAVPIVSARWSDWIRKQFQVGRLTQ 227
[Close]
BLAST of Homeobox protein vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 115.546 bits (288), Expect = 1.598e-28
Identity = 49/63 (77.78%), Postives = 59/63 (93.65%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            ++R+RR+LFS+AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR++ +
Sbjct:  127 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAE 189
[Close]
BLAST of Homeobox protein vs. UniProt/SwissProt
Match: sp|Q00401|HMH2_GIRTI (Homeobox protein DTH-2 OS=Girardia tigrina OX=6162 GN=DTH-2 PE=2 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 5.700e-39
Identity = 72/108 (66.67%), Postives = 84/108 (77.78%), Query Frame = 3 
Query:  675 GMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCN 998
             M + + SQRR+RRILFSQAQ+YELERRFKQQKYLSAPEREHLA+LINLTPTQVKIWFQNHRYKCKRSQKD EK+QQK +     + H   + V   +   N+  +CN
Sbjct:  124 AMQFNNMSQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQQKEK-----SYHLKKNIVDDKERSPNKQ-ICN 225
[Close]
BLAST of Homeobox protein vs. UniProt/SwissProt
Match: sp|Q9EQM3|NKX24_MOUSE (Homeobox protein Nkx-2.4 OS=Mus musculus OX=10090 GN=Nkx2-4 PE=2 SV=2)

HSP 1 Score: 130.183 bits (326), Expect = 3.039e-32
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  188 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 258
[Close]
BLAST of Homeobox protein vs. UniProt/SwissProt
Match: sp|Q9H2Z4|NKX24_HUMAN (Homeobox protein Nkx-2.4 OS=Homo sapiens OX=9606 GN=NKX2-4 PE=1 SV=3)

HSP 1 Score: 128.257 bits (321), Expect = 1.594e-31
Identity = 57/71 (80.28%), Postives = 63/71 (88.73%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q ++E
Sbjct:  189 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE 259
[Close]
BLAST of Homeobox protein vs. UniProt/SwissProt
Match: sp|P43698|TITF1_CANLF (Thyroid transcription factor 1 OS=Canis lupus familiaris OX=9615 GN=TITF1 PE=2 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 7.325e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. UniProt/SwissProt
Match: sp|P43699|NKX21_HUMAN (Homeobox protein Nkx-2.1 OS=Homo sapiens OX=9606 GN=NKX2-1 PE=1 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 9.462e-31
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 222
[Close]
BLAST of Homeobox protein vs. TrEMBL
Match: A0A1W6AZH9 (Nk2.1 OS=Membranipora membranacea OX=95170 GN=nk2.1 PE=2 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 6.746e-35
Identity = 87/179 (48.60%), Postives = 106/179 (59.22%), Query Frame = 3 
Query:  375 SLISCSSFSNAYYGADIAGLYAAEPRPFNV---PGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTS--SGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEK 896
            S  S + F + Y  AD++  Y       N    P  +T+PT+               A+S+L+G S+ S  S +     N M+       YD+   +   N PI        SQRR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLA +INLTPTQVKIWFQNHRYKCKR+QKD EK
Sbjct:   90 SHASTAGFGSQYGAADLSHAYDTTRHTANSWYSPSAATDPTSRF----------NEYALSRLMGPSNCSMTSMSQMGMSNHMNAMHGLGGYDKHPGM---NFPI--------SQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAQMINLTPTQVKIWFQNHRYKCKRAQKDKEK 247
[Close]
BLAST of Homeobox protein vs. TrEMBL
Match: A0A0Y0HYM7 (Homeodomain protein NK2.1 OS=Leptochiton asellus OX=211853 PE=2 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 8.583e-35
Identity = 81/134 (60.45%), Postives = 94/134 (70.15%), Query Frame = 3 
Query:  513 GINTDTR----SAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSG--NSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEK 896
            G NTD R    +AVS+L+G S      A NP         SS  +  S   SG   + ++GM +   +QRR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+INLTPTQVKIWFQNHRYKCKR QKD +K
Sbjct:  103 GPNTDPRFASYAAVSRLMGPSSC----AMNPM--------SSGMNHMSMSLSGMDQAKMHGMQFPL-TQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMINLTPTQVKIWFQNHRYKCKRQQKDKDK 223
[Close]
BLAST of Homeobox protein vs. TrEMBL
Match: H6WCV9 (NK2.1 OS=Terebratalia transversa OX=34513 GN=NK2.1 PE=2 SV=1)

HSP 1 Score: 141.354 bits (355), Expect = 3.503e-34
Identity = 67/86 (77.91%), Postives = 74/86 (86.05%), Query Frame = 3 
Query:  675 GMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMST 932
            GM + S  QRR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+INLTPTQVKIWFQNHRYKCKR+ KD EKD  +   TG S+
Sbjct:  148 GMQFSS-LQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMINLTPTQVKIWFQNHRYKCKRALKDKEKDGSRDGTTGRSS 232
[Close]
BLAST of Homeobox protein vs. TrEMBL
Match: A0A165US97 (NK2.1 OS=Owenia fusiformis OX=6347 PE=2 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 7.883e-33
Identity = 97/241 (40.25%), Postives = 133/241 (55.19%), Query Frame = 3 
Query:  336 TDGSYSSYRSFGPSLISCSSFSNAYYGADIAGLYAAEPRPFNVPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEK-DQQKREITGMSTVHSPADSVTSADH--CDNRHNVCNLFQNQQSKTSGLSASPP 1049
            T+  ++SY +  PSL   S++S   Y +     Y    R      Y TNP++             R A+S+L+GA  +S  ++    N MS    +  YD + +      P+   L    +QRR+RR+LFSQAQVYELERRFK QKYLSAPEREHLA++INLTPTQ+KIWFQNHRYK KR QKD EK D++++  +   +    A  V   D   C   +N  +   +QQ +T   +A  P
Sbjct:   61 TNPYHTSY-TMPPSLTHHSAYSPQCYQSPELSHYGDPTRQSASSWYGTNPSD-----------PARFAISRLMGAQPSSCMSSMPGMNQMS--MSALGYDHTKH------PLQYPL----TQRRKRRVLFSQAQVYELERRFKSQKYLSAPEREHLANMINLTPTQIKIWFQNHRYKHKRQQKDKEKLDEREKSSSSQQSPRRVAVPVLVKDGKPCSGTNNSDSSHSSQQPQTGATAAHTP 277
[Close]
BLAST of Homeobox protein vs. TrEMBL
Match: A0A0K1NZ93 (NK2.1 homeobox (Fragment) OS=Priapulus caudatus OX=37621 GN=NK2.1 PE=2 SV=1)

HSP 1 Score: 134.806 bits (338), Expect = 1.580e-32
Identity = 87/191 (45.55%), Postives = 110/191 (57.59%), Query Frame = 3 
Query:  351 SSYRSFGPSLISCSSFSNAYY-GADIAGLYAAEPRPFNVPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSH----SQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQK 908
            S Y    P L   SSF + Y  GA+++  +  +P    V   ST    W        N D R A+S+L+  S   SG   N                 S+  S  + I+G +++      +QRR+RR+LF+QAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR+ KD +  + +
Sbjct:   65 SPYHMHVPQLSHHSSFPSQYCNGAELS--HYGDPTGLAVRHSSTG---WYT-----ANPDPRFAISRLMSHS---SGMNMN----------------MSSTVSALNGIDGGMHKGMQFPLTQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRATKDKQMQEHQ 226
[Close]
BLAST of Homeobox protein vs. Ensembl Cavefish
Match: nkx2.1 (homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103043023])

HSP 1 Score: 130.183 bits (326), Expect = 3.130e-33
Identity = 76/145 (52.41%), Postives = 90/145 (62.07%), Query Frame = 3 
Query:  474 STNPTNWCCNMSGGINTDTR-SAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQ 905
            ST  T+W      G N D R S +S+ +G+S     +  N  ++             S+L S      GM   S + RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    QQ
Sbjct:  106 STTATSWY-----GTNPDPRFSTISRFMGSS-----SGMNMGSM-------------SSLGSLADVGKGMGSLSSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKVSQQQ 227
[Close]
BLAST of Homeobox protein vs. Ensembl Cavefish
Match: nkx2.4b (NK2 homeobox 4 [Source:NCBI gene;Acc:103036401])

HSP 1 Score: 121.709 bits (304), Expect = 2.119e-30
Identity = 53/62 (85.48%), Postives = 58/62 (93.55%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQ+YLSAPEREHLAS+I+LTP QVKIWFQNHRYK KR  KD
Sbjct:  143 RRKRRVLFSQAQVYELERRFKQQRYLSAPEREHLASMIHLTPNQVKIWFQNHRYKMKRQAKD 204
[Close]
BLAST of Homeobox protein vs. Ensembl Cavefish
Match: ENSAMXT00000002203.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:20913167:20916891:1 gene:ENSAMXG00000002158.2 transcript:ENSAMXT00000002203.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 101.293 bits (251), Expect = 6.362e-25
Identity = 44/67 (65.67%), Postives = 57/67 (85.07%), Query Frame = 3 
Query:  687 QSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +   ++++RR+LFS+ Q YELERRF+QQ+YLSAPEREHLA  + LTPTQVKIWFQNHRYK KR++ +
Sbjct:   12 EMEQKKKKRRVLFSKTQTYELERRFRQQRYLSAPEREHLARALRLTPTQVKIWFQNHRYKMKRARTE 78
[Close]
BLAST of Homeobox protein vs. Ensembl Cavefish
Match: nkx2.3 (NK2 homeobox 3 [Source:NCBI gene;Acc:103034978])

HSP 1 Score: 105.145 bits (261), Expect = 1.442e-24
Identity = 46/57 (80.70%), Postives = 52/57 (91.23%), Query Frame = 3 
Query:  717 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +LFSQAQV+ELERRFKQQ+YLSAPEREHLAS + LT TQVKIWFQN RYKCKR ++D
Sbjct:  154 VLFSQAQVFELERRFKQQRYLSAPEREHLASALKLTSTQVKIWFQNRRYKCKRQRQD 210
[Close]
BLAST of Homeobox protein vs. Ensembl Cavefish
Match: nkx2.5 (homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103025318])

HSP 1 Score: 102.064 bits (253), Expect = 1.289e-23
Identity = 45/63 (71.43%), Postives = 53/63 (84.13%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            +RR+ R+LFSQAQV ELERRF QQ+YLSA EREHLA  + LT TQVKIWFQN RYKCKR +++
Sbjct:  131 KRRKPRVLFSQAQVCELERRFTQQRYLSAAEREHLAGALRLTSTQVKIWFQNRRYKCKRQRQE 193
[Close]
BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Match: nkx2.1 (NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1])

HSP 1 Score: 126.331 bits (316), Expect = 9.484e-34
Identity = 55/62 (88.71%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:   40 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 101
[Close]
BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005776.1 (pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1 gene:ENSPMAG00000005236.1 transcript:ENSPMAT00000005776.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 107.842 bits (268), Expect = 9.244e-29
Identity = 46/61 (75.41%), Postives = 57/61 (93.44%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQ 881
            ++R+RR+LFS+AQ +ELERRF+ Q+YLSAPEREHLASL+ LTPTQVKIWFQNHRYK KR++
Sbjct:    1 KKRKRRVLFSKAQTFELERRFRHQRYLSAPEREHLASLLKLTPTQVKIWFQNHRYKMKRAR 61
[Close]
BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010860.1 (pep scaffold:Pmarinus_7.0:GL477006:70988:76921:1 gene:ENSPMAG00000009840.1 transcript:ENSPMAT00000010860.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 71.2478 bits (173), Expect = 1.091e-15
Identity = 36/87 (41.38%), Postives = 54/87 (62.07%), Query Frame = 3 
Query:  669 INGMLYQSHSQRRRR---RILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRS-----QKDIEKDQQ 905
            + G   Q  + +R+R   R +FS  Q   LE+RF+ QKY++ P+R  LA+++ LT  QVK+WFQN R K + S     QKD EK+++
Sbjct:    7 VGGPCLQGAAFKRKRAWSRAVFSSLQRKGLEKRFQVQKYVTKPDRRQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAEAQKDKEKEKE 93
[Close]
BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.4774 bits (171), Expect = 2.552e-15
Identity = 39/87 (44.83%), Postives = 50/87 (57.47%), Query Frame = 3 
Query:  705 RRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSA 965
            RR R  FS  Q+ ELER F +Q+YLS P+R  +AS + LT TQVKIWFQN R K KR +    +++Q            PA +  SA
Sbjct:    4 RRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKWKRGKGGQLQEKQSLGPARNGQAGRPAPAAASA 90
[Close]
BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Match: HMX1 (H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017])

HSP 1 Score: 65.0846 bits (157), Expect = 3.684e-13
Identity = 30/58 (51.72%), Postives = 44/58 (75.86%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 875
            +++ R +FS++QV++LE  F  ++YLS+ ER  LA+ ++LT TQVKIWFQN R K KR
Sbjct:    1 KKKTRTVFSRSQVFQLESTFDMKRYLSSAERAGLAASLHLTETQVKIWFQNRRNKWKR 58
[Close]
BLAST of Homeobox protein vs. Ensembl Nematostella
Match: NK-4 (NK-4 homeobox protein; Predicted protein [Source:UniProtKB/TrEMBL;Acc:Q7YZD1])

HSP 1 Score: 108.997 bits (271), Expect = 1.199e-26
Identity = 48/58 (82.76%), Postives = 53/58 (91.38%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 875
            RR+ R+LFSQAQVYELERRFK QKYLSAPER+HLASL+ LTP QVKIWFQN RYKCK+
Sbjct:  155 RRKPRVLFSQAQVYELERRFKGQKYLSAPERDHLASLLKLTPNQVKIWFQNKRYKCKK 212
[Close]
BLAST of Homeobox protein vs. Ensembl Nematostella
Match: EDO33946 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP5])

HSP 1 Score: 103.99 bits (258), Expect = 1.282e-26
Identity = 45/59 (76.27%), Postives = 55/59 (93.22%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 875
            ++R+RR+LF++AQ YELERRF+QQ+YLSAPERE LA +INLTPTQVKIWFQNHRYK K+
Sbjct:    6 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREQLARIINLTPTQVKIWFQNHRYKFKK 64
[Close]
BLAST of Homeobox protein vs. Ensembl Nematostella
Match: EDO45871 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRR7])

HSP 1 Score: 101.679 bits (252), Expect = 1.607e-26
Identity = 42/61 (68.85%), Postives = 56/61 (91.80%), Query Frame = 3 
Query:  702 RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQK 884
            ++++RILF+++Q+YELERRF+ Q+YLSAPEREHLA +I+LTP QVKIWFQNHRYKC++  K
Sbjct:    1 KKKKRILFTRSQIYELERRFRVQQYLSAPEREHLARMISLTPVQVKIWFQNHRYKCRQRYK 61
[Close]
BLAST of Homeobox protein vs. Ensembl Nematostella
Match: NK-2 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP7])

HSP 1 Score: 107.071 bits (266), Expect = 1.801e-26
Identity = 54/99 (54.55%), Postives = 73/99 (73.74%), Query Frame = 3 
Query:  654 SGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGM--STVHSP 944
            SG   +      SH ++++RRILF+++Q++ELERRF+QQKYLSA ERE LA +I+LTPTQVKIWFQNHRYK K+     EKDQ  R+++    S+V +P
Sbjct:   75 SGLQDVPKFTTSSHVRKKKRRILFTKSQIFELERRFRQQKYLSANEREQLARIIDLTPTQVKIWFQNHRYKFKKQIG--EKDQFYRDVSAAFCSSVGAP 171
[Close]
BLAST of Homeobox protein vs. Ensembl Nematostella
Match: EDO33947 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP6])

HSP 1 Score: 98.5969 bits (244), Expect = 3.664e-25
Identity = 43/59 (72.88%), Postives = 54/59 (91.53%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 875
            ++R+RRILF+++Q+YELERRF+ Q+YLSAPERE L  +INLTPTQVKIWFQNHRYK K+
Sbjct:    1 KKRKRRILFTKSQIYELERRFRYQRYLSAPEREQLGRMINLTPTQVKIWFQNHRYKHKK 59
[Close]
BLAST of Homeobox protein vs. Ensembl Medaka
Match: nkx2.4a (homeobox protein Nkx-2.4-like [Source:NCBI gene;Acc:101163285])

HSP 1 Score: 129.413 bits (324), Expect = 4.541e-33
Identity = 64/97 (65.98%), Postives = 72/97 (74.23%), Query Frame = 3 
Query:  618 PSSRYDRSSNLFSGNSPINGMLYQSHSQ-------RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            P  RY  S N+ +G   + GM   S +        RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD
Sbjct:  117 PDPRYSTSMNM-TGMGSLTGMADASKAMPALHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 212
[Close]
BLAST of Homeobox protein vs. Ensembl Medaka
Match: nkx2.1 (NK2 homeobox 1 [Source:NCBI gene;Acc:100049404])

HSP 1 Score: 129.413 bits (324), Expect = 5.485e-33
Identity = 60/83 (72.29%), Postives = 67/83 (80.72%), Query Frame = 3 
Query:  675 GMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITG 923
            GM   S + RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLAS+I+LTPTQVKIWFQNHRYK KR  KD    Q  ++  G
Sbjct:  150 GMSSLSSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKASQQHLQQDGG 232
[Close]
BLAST of Homeobox protein vs. Ensembl Medaka
Match: ENSORLT00000021504.2 (NK2 homeobox 4 [Source:NCBI gene;Acc:101162726])

HSP 1 Score: 127.487 bits (319), Expect = 1.884e-32
Identity = 87/221 (39.37%), Postives = 115/221 (52.04%), Query Frame = 3 
Query:  453 PFNVPGYSTNPTNWCCNMSGGI-NTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPS-SRYDRSSNLFSGNSPINGMLYQSHSQ----------RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE--------ITGMSTVHSPADSVTSADHCDNRHNVC---NLFQNQQSKTSGLSASP 1046
            P  VP +S   + +C   +GGI N        + + +   ++    NP     P +P+ SRY  +S   + +  + G+     S           RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLA LI+LTP QVKIWFQNHRYK KR  KD    Q + +         TG S+  SP   V S +   +R + C   N    Q      ++A+P
Sbjct:   70 PHGVPQFSGAVSGFC---NGGISNVGDLPTYQETVRSGGATTAWYSNP----EPRYPTISRYMGASAGMNMSGMVGGLAGMDSSAKSVVTLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAGLIHLTPNQVKIWFQNHRYKLKRQAKDKAAQQPQHDSGGGAASATTGRSSSVSP---VLSKNAKGSRTDSCGSNNTGNRQGGSGDAMTATP 280
[Close]
BLAST of Homeobox protein vs. Ensembl Medaka
Match: ENSORLT00000042590.1 (NK2 homeobox 4 [Source:NCBI gene;Acc:101162726])

HSP 1 Score: 127.872 bits (320), Expect = 2.372e-32
Identity = 87/221 (39.37%), Postives = 115/221 (52.04%), Query Frame = 3 
Query:  453 PFNVPGYSTNPTNWCCNMSGGI-NTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPS-SRYDRSSNLFSGNSPINGMLYQSHSQ----------RRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE--------ITGMSTVHSPADSVTSADHCDNRHNVC---NLFQNQQSKTSGLSASP 1046
            P  VP +S   + +C   +GGI N        + + +   ++    NP     P +P+ SRY  +S   + +  + G+     S           RR+RR+LFSQAQVYELERRFKQQKYLSAPEREHLA LI+LTP QVKIWFQNHRYK KR  KD    Q + +         TG S+  SP   V S +   +R + C   N    Q      ++A+P
Sbjct:   89 PHGVPQFSGAVSGFC---NGGISNVGDLPTYQETVRSGGATTAWYSNP----EPRYPTISRYMGASAGMNMSGMVGGLAGMDSSAKSVVTLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAGLIHLTPNQVKIWFQNHRYKLKRQAKDKAAQQPQHDSGGGAASATTGRSSSVSP---VLSKNAKGSRTDSCGSNNTGNRQGGSGDAMTATP 299
[Close]
BLAST of Homeobox protein vs. Ensembl Medaka
Match: nkx2.2a (homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:101157822])

HSP 1 Score: 117.087 bits (292), Expect = 3.346e-29
Identity = 54/83 (65.06%), Postives = 63/83 (75.90%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPA 947
            ++R+RR+LFS+AQ YELERRF+QQ+YLSAPEREHLASLI LTPTQVKIWFQNHRYK KR+          R   GM   H P+
Sbjct:  128 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRA----------RAEKGMEVTHLPS 200
[Close]
BLAST of Homeobox protein vs. Planmine SMEST
Match: SMESG000081885.1 (SMESG000081885.1)

HSP 1 Score: 779.63 bits (2012), Expect = 0.000e+0
Identity = 391/392 (99.74%), Postives = 392/392 (100.00%), Query Frame = 3 
Query:  312 MSLQPSCSTDGSYSSYRSFGPSLISCSSFSNAYYGADIAGLYAAEPRPFNVPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCNLFQNQQSKTSGLSASPPIMKISENIPDNSLSQVKVEDQNDMTFAFSKSILPGKFSEKPNDSQLKENIXXXXXXXXXXXXQYYQHLQSRYNYNINISDLRAPSLIPDLDSINKSESSLVFPSIFTSTEQLLPIISESGTIYPSEFPNLPFPNNDSYHFSSNKPW 1487
            MSLQPSCSTDGSYSSYRSFGPSLISCSSFSNAYYGADIAGLYAAEPRPFNVPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCNLFQNQQSKTSGLSASPPIMKISENIPDNSLSQVKVEDQNDMTFAFSKSILPGKFSEKPNDSQLKE+ISSNVSMDCSSMSQYYQHLQSRYNYNINISDLRAPSLIPDLDSINKSESSLVFPSIFTSTEQLLPIISESGTIYPSEFPNLPFPNNDSYHFSSNKPW
Sbjct:    1 MSLQPSCSTDGSYSSYRSFGPSLISCSSFSNAYYGADIAGLYAAEPRPFNVPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSPFFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCNLFQNQQSKTSGLSASPPIMKISENIPDNSLSQVKVEDQNDMTFAFSKSILPGKFSEKPNDSQLKESISSNVSMDCSSMSQYYQHLQSRYNYNINISDLRAPSLIPDLDSINKSESSLVFPSIFTSTEQLLPIISESGTIYPSEFPNLPFPNNDSYHFSSNKPW 392
[Close]
BLAST of Homeobox protein vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 145.591 bits (366), Expect = 8.097e-39
Identity = 82/144 (56.94%), Postives = 100/144 (69.44%), Query Frame = 3 
Query:  519 NTDTRSAVSKLIG-ASDTSSGTAYNPCNLMSPF--FPSSRYDRSSNLFSGNSPINGMLYQSH---------SQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            N+D R A+S+L+G A+  +SG        MS +   PS+ + +  +   G S +    Y+           SQRR+RRILFSQAQ+YELERRFKQQKYLSAPEREHLA+LINLTPTQVKIWFQNHRYKCKRSQKD EK+Q K +
Sbjct:   68 NSDPRMAMSRLMGTAAAAASGN-------MSVYAGIPSN-FHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEK 203
[Close]
BLAST of Homeobox protein vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 145.206 bits (365), Expect = 1.003e-38
Identity = 82/144 (56.94%), Postives = 100/144 (69.44%), Query Frame = 3 
Query:  519 NTDTRSAVSKLIG-ASDTSSGTAYNPCNLMSPF--FPSSRYDRSSNLFSGNSPINGMLYQSH---------SQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKRE 914
            N+D R A+S+L+G A+  +SG        MS +   PS+ + +  +   G S +    Y+           SQRR+RRILFSQAQ+YELERRFKQQKYLSAPEREHLA+LINLTPTQVKIWFQNHRYKCKRSQKD EK+Q K +
Sbjct:   59 NSDPRMAMSRLMGTAAAAASGN-------MSVYAGIPSN-FHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEK 194
[Close]
BLAST of Homeobox protein vs. Planmine SMEST
Match: SMESG000062916.1 (SMESG000062916.1)

HSP 1 Score: 120.553 bits (301), Expect = 8.835e-31
Identity = 70/150 (46.67%), Postives = 92/150 (61.33%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKREITGMSTVHSPADSVTSADHCDNRHNVCNLFQNQQSKTSGLSASPPIMKISENIPDNSLSQVKVEDQNDMTFAFSKSIL 1148
            QRR+RRILFSQ+QVYELER+FK QKYLSA ER+ LA  INLTP QVKIWFQNHRYKCKR +KD+E  Q +R++              S++   N  ++ +L     S+ S  S  PP  + S    +N  S  +  D+   TF F+ S++
Sbjct:  129 QRRKRRILFSQSQVYELERKFKHQKYLSASERDQLAQTINLTPNQVKIWFQNHRYKCKRIEKDMEHMQSQRKLK------------ISSNSKKNDASIISL----NSQRSASSTIPPGSQYSIYGDNNIQSSCRPIDEVASTFPFAPSLI 262
[Close]
BLAST of Homeobox protein vs. Planmine SMEST
Match: SMESG000079512.1 (SMESG000079512.1)

HSP 1 Score: 107.071 bits (266), Expect = 1.427e-24
Identity = 44/63 (69.84%), Postives = 56/63 (88.89%), Query Frame = 3 
Query:  699 QRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 887
            ++R+RR+LFS+ Q+ ELER F+Q+KYLSAPEREHLA+LI L+PTQVKIWFQNHRYK KR+  +
Sbjct:  365 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHE 427
The following BLAST results are available for this feature:
BLAST of Homeobox protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NKX2-43.318e-3280.28NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837][more]
NKX2-11.970e-3188.71NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825][more]
NKX2-11.970e-3188.71NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825][more]
NKX2-11.970e-3188.71NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825][more]
NKX2-13.032e-3188.71NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825][more]
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BLAST of Homeobox protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ceh-243.266e-3081.82Homeobox protein ceh-24 [Source:UniProtKB/Swiss-P... [more]
ceh-221.540e-2375.44Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P... [more]
ceh-222.924e-2375.44Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P... [more]
ceh-226.304e-2375.44Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P... [more]
ceh-221.108e-2275.44Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P... [more]
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BLAST of Homeobox protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scro3.980e-3454.07gene:FBgn0028993 transcript:FBtr0339923[more]
scro4.281e-3354.48gene:FBgn0028993 transcript:FBtr0113751[more]
vnd5.956e-2865.38gene:FBgn0261930 transcript:FBtr0070110[more]
vnd6.780e-2865.38gene:FBgn0261930 transcript:FBtr0110929[more]
scro4.209e-2052.78gene:FBgn0028993 transcript:FBtr0113752[more]
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BLAST of Homeobox protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nkx2.11.022e-3349.67NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1][more]
nkx2.4a1.731e-3362.26NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6... [more]
nkx2.4b9.367e-3383.82NK2 homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-000830-1... [more]
nkx2.4a2.062e-3280.28NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6... [more]
nkx2.2a2.646e-2965.06NK2 homeobox 2a [Source:NCBI gene;Acc:30697][more]
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BLAST of Homeobox protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
trpc32.812e-3353.19transient receptor potential cation channel, subfa... [more]
fam221a1.354e-3280.28family with sequence similarity 221 member A [Sour... [more]
NKX2-22.414e-2877.78NK2 homeobox 2 [Source:NCBI gene;Acc:100038077][more]
ENSXETT00000008392.11.990e-2669.57homeobox protein Nkx-2.1-like [Source:NCBI gene;Ac... [more]
mtm11.000e-2573.85myotubularin 1 [Source:Xenbase;Acc:XB-GENE-1002030... [more]
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BLAST of Homeobox protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nkx2-44.344e-3380.28NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349][more]
Nkx2-11.744e-3188.71NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067][more]
Nkx2-11.744e-3188.71NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067][more]
Nkx2-21.125e-2956.73NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347][more]
Nkx2-21.598e-2877.78NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347][more]
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BLAST of Homeobox protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q00401|HMH2_GIRTI5.700e-3966.67Homeobox protein DTH-2 OS=Girardia tigrina OX=6162... [more]
sp|Q9EQM3|NKX24_MOUSE3.039e-3280.28Homeobox protein Nkx-2.4 OS=Mus musculus OX=10090 ... [more]
sp|Q9H2Z4|NKX24_HUMAN1.594e-3180.28Homeobox protein Nkx-2.4 OS=Homo sapiens OX=9606 G... [more]
sp|P43698|TITF1_CANLF7.325e-3188.71Thyroid transcription factor 1 OS=Canis lupus fami... [more]
sp|P43699|NKX21_HUMAN9.462e-3188.71Homeobox protein Nkx-2.1 OS=Homo sapiens OX=9606 G... [more]
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BLAST of Homeobox protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1W6AZH96.746e-3548.60Nk2.1 OS=Membranipora membranacea OX=95170 GN=nk2.... [more]
A0A0Y0HYM78.583e-3560.45Homeodomain protein NK2.1 OS=Leptochiton asellus O... [more]
H6WCV93.503e-3477.91NK2.1 OS=Terebratalia transversa OX=34513 GN=NK2.1... [more]
A0A165US977.883e-3340.25NK2.1 OS=Owenia fusiformis OX=6347 PE=2 SV=1[more]
A0A0K1NZ931.580e-3245.55NK2.1 homeobox (Fragment) OS=Priapulus caudatus OX... [more]
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BLAST of Homeobox protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nkx2.13.130e-3352.41homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103... [more]
nkx2.4b2.119e-3085.48NK2 homeobox 4 [Source:NCBI gene;Acc:103036401][more]
ENSAMXT00000002203.26.362e-2565.67pep primary_assembly:Astyanax_mexicanus-2.0:9:2091... [more]
nkx2.31.442e-2480.70NK2 homeobox 3 [Source:NCBI gene;Acc:103034978][more]
nkx2.51.289e-2371.43homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103... [more]
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BLAST of Homeobox protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nkx2.19.484e-3488.71NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1][more]
ENSPMAT00000005776.19.244e-2975.41pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1... [more]
ENSPMAT00000010860.11.091e-1541.38pep scaffold:Pmarinus_7.0:GL477006:70988:76921:1 g... [more]
ENSPMAT00000001141.12.552e-1544.83pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 ... [more]
HMX13.684e-1351.72H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of Homeobox protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Homeobox protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
NK-41.199e-2682.76NK-4 homeobox protein; Predicted protein [Source:... [more]
EDO339461.282e-2676.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458711.607e-2668.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
NK-21.801e-2654.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO339473.664e-2572.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Homeobox protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nkx2.4a4.541e-3365.98homeobox protein Nkx-2.4-like [Source:NCBI gene;Ac... [more]
nkx2.15.485e-3372.29NK2 homeobox 1 [Source:NCBI gene;Acc:100049404][more]
ENSORLT00000021504.21.884e-3239.37NK2 homeobox 4 [Source:NCBI gene;Acc:101162726][more]
ENSORLT00000042590.12.372e-3239.37NK2 homeobox 4 [Source:NCBI gene;Acc:101162726][more]
nkx2.2a3.346e-2965.06homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:10... [more]
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BLAST of Homeobox protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081885.10.000e+099.74SMESG000081885.1[more]
SMESG000037282.18.097e-3956.94SMESG000037282.1[more]
SMESG000037282.11.003e-3856.94SMESG000037282.1[more]
SMESG000062916.18.835e-3146.67SMESG000062916.1[more]
SMESG000079512.11.427e-2469.84SMESG000079512.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005185 ID=SMED30005185|Name=Homeobox protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1544bp
ATAGAGTTCGATGCTGGATTCTCTCAGTTTTCGCAGTGAGTATTCTTCAT
CAGCGTTTGAGCACTCTTCACTCAGTTTCAACAACCATCACTGGATCGAC
TCAGACACTTCTAAGTGGATCACAAGTATCACATCAATATCGTAAGCCTT
CCAGCAACAAGCTATTTTCCACAACTAAACATTCTTCAAATATACACTTG
TCAAATATTTCAAAACATCTCCAAATAACAATTGACACCGATTTTAAATT
TTTTTTATACTTGCACCTCATTCAAGTAATTTAGAACCGAGTGGGTCACT
TGAACTAGCCAATGTCTTTACAGCCTTCTTGTAGTACTGATGGCTCTTAC
TCGTCCTATCGTTCGTTTGGGCCTTCATTAATCTCATGCTCATCATTTTC
AAATGCATATTATGGTGCTGATATAGCGGGACTCTATGCGGCCGAGCCTC
GACCATTTAATGTACCTGGCTATTCAACTAACCCTACAAATTGGTGTTGT
AATATGTCAGGAGGAATCAACACAGATACTAGATCAGCAGTATCCAAATT
AATAGGCGCTTCAGATACTTCATCCGGCACAGCTTATAATCCATGCAATT
TAATGTCACCGTTTTTCCCATCGAGTCGATATGACAGATCTAGTAATTTA
TTTTCTGGCAATTCACCAATAAATGGAATGCTATATCAAAGTCATTCTCA
AAGACGACGAAGACGCATACTGTTCAGTCAAGCTCAGGTGTATGAATTAG
AAAGACGGTTCAAGCAACAAAAATATTTGTCGGCTCCAGAAAGAGAACAT
TTGGCATCATTAATCAATTTAACACCTACACAAGTAAAAATATGGTTTCA
AAATCATCGCTACAAATGCAAAAGATCTCAAAAAGATATTGAAAAAGATC
AACAAAAACGAGAAATAACTGGAATGAGTACAGTCCATAGTCCGGCTGAC
AGTGTGACAAGCGCAGATCATTGTGATAATAGGCATAATGTATGTAATTT
ATTTCAAAATCAGCAATCAAAAACTTCAGGATTGAGTGCATCACCACCAA
TAATGAAAATTTCAGAAAACATACCAGACAATTCTTTATCCCAGGTGAAA
GTGGAAGATCAAAACGACATGACATTTGCATTTTCCAAATCCATTCTACC
GGGAAAGTTTTCAGAAAAGCCCAATGATTCCCAACTAAAAGAAAATATTT
CATCAAACGTTTCTATGGATTGTTCAAGCATGTCTCAATATTATCAACAT
TTACAATCAAGATATAATTATAACATCAACATTTCTGATTTGAGAGCTCC
TTCGCTTATTCCTGACTTAGATTCCATTAACAAATCCGAATCTTCATTGG
TATTTCCATCCATATTTACTAGTACGGAACAACTGTTACCCATAATTTCA
GAATCTGGCACTATATACCCATCAGAATTTCCTAATCTACCATTCCCAAA
TAATGATTCCTATCACTTTAGTTCAAACAAACCATGGTGAAATACAAAAT
TATCTCACTAAATTATGCTTCAATTAAACTACTTATTGTTTAAC
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protein sequence of SMED30005185-orf-1

>SMED30005185-orf-1 ID=SMED30005185-orf-1|Name=SMED30005185-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=393bp
MSLQPSCSTDGSYSSYRSFGPSLISCSSFSNAYYGADIAGLYAAEPRPFN
VPGYSTNPTNWCCNMSGGINTDTRSAVSKLIGASDTSSGTAYNPCNLMSP
FFPSSRYDRSSNLFSGNSPINGMLYQSHSQRRRRRILFSQAQVYELERRF
KQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKDIEKDQQKR
EITGMSTVHSPADSVTSADHCDNRHNVCNLFQNQQSKTSGLSASPPIMKI
SENIPDNSLSQVKVEDQNDMTFAFSKSILPGKFSEKPNDSQLKENISSNV
SMDCSSMSQYYQHLQSRYNYNINISDLRAPSLIPDLDSINKSESSLVFPS
IFTSTEQLLPIISESGTIYPSEFPNLPFPNNDSYHFSSNKPW*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000103central nervous system
PLANA:0000418head
PLANA:0000419prepharyngeal region
PLANA:0000463cholinergic neuron
PLANA:0000464GABAergic neuron
PLANA:0000483octopaminergic neuron
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR020479Homeobox_metazoa
IPR001356Homeobox_dom
IPR009057Homeobox-like_sf
IPR017970Homeobox_CS
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0043565sequence-specific DNA binding
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR020479Homeobox domain, metazoaPRINTSPR00024HOMEOBOXcoord: 168..178
score: 57.42
coord: 153..164
score: 41.38
coord: 178..187
score: 69.65
IPR001356Homeobox domainSMARTSM00389HOX_1coord: 131..193
e-value: 9.9E-25
score: 98.2
IPR001356Homeobox domainPFAMPF00046Homeodomaincoord: 132..188
e-value: 2.7E-19
score: 68.8
IPR001356Homeobox domainPROSITEPS50071HOMEOBOX_2coord: 129..189
score: 19.921
IPR001356Homeobox domainCDDcd00086homeodomaincoord: 138..190
e-value: 9.89554E-22
score: 85.758
NoneNo IPR availableGENE3DG3DSA:1.10.10.60coord: 102..193
e-value: 3.1E-24
score: 87.0
NoneNo IPR availablePANTHERPTHR24340FAMILY NOT NAMEDcoord: 83..271
NoneNo IPR availablePANTHERPTHR24340:SF41SCARECROW, ISOFORM Acoord: 83..271
IPR017970Homeobox, conserved sitePROSITEPS00027HOMEOBOX_1coord: 164..187
IPR009057Homeobox-like domain superfamilySUPERFAMILYSSF46689Homeodomain-likecoord: 114..191