Alkaline ceramidase

Overview
NameAlkaline ceramidase
Smed IDSMED30005178
Length (bp)3143
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Alkaline ceramidase (SMED30005178) t-SNE clustered cells

Violin plots show distribution of expression levels for Alkaline ceramidase (SMED30005178) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Alkaline ceramidase (SMED30005178) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Alkaline ceramidase (SMED30005178) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30005178

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30005178h1SMcG0005328 dd_Smed_v6_9570_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Category 4 cellSMED30005178h1SMcG0005328 dd_Smed_v4_9570_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Human
Match: ACER3 (alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066])

HSP 1 Score: 192.2 bits (487), Expect = 1.840e-54
Identity = 103/272 (37.87%), Postives = 152/272 (55.88%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            + GYW P T+T+DWCEENY V++YIAEFWNT+SN +MI  P+     S    +   +   YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK++ +        L+++S++VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S   + +GF FWNIDNIFC+ L+NFR     +I   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P++
Sbjct:    7 REGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFEC-------------------FKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVI 259
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Human
Match: ACER3 (alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066])

HSP 1 Score: 160.229 bits (404), Expect = 8.541e-44
Identity = 92/272 (33.82%), Postives = 134/272 (49.26%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            + GYW P T+T+DWCEENY V++YIAEF                                     LVG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK++ +        L+++S++VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S   + +GF FWNIDNIFC+ L+NFR     +I   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P++
Sbjct:    7 REGYWGPTTSTLDWCEENYSVTWYIAEF-------------------------------------LVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFEC-------------------FKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVI 222
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Human
Match: ACER3 (alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066])

HSP 1 Score: 134.806 bits (338), Expect = 2.988e-35
Identity = 72/187 (38.50%), Postives = 105/187 (56.15%), Query Frame = 1 
Query: 2392 YLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIF 2949
            YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK++ +        L+++S++VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S   + +GF FWNIDNIFC+ L+NFR     +I   +Q HAWWHI +G GSY +++F
Sbjct:   25 YLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFEC-------------------FKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILF 192
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Human
Match: ACER3 (alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066])

HSP 1 Score: 95.5153 bits (236), Expect = 6.331e-22
Identity = 49/149 (32.89%), Postives = 81/149 (54.36%), Query Frame = 1 
Query: 2581 FKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            FK++ +        L+++S++VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S   + +GF FWNIDNIFC+ L+NFR     +I   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P++
Sbjct:   16 FKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVI 164
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Human
Match: ACER2 (alkaline ceramidase 2 [Source:HGNC Symbol;Acc:HGNC:23675])

HSP 1 Score: 77.0258 bits (188), Expect = 1.067e-14
Identity = 69/259 (26.64%), Postives = 113/259 (43.63%), Query Frame = 1 
Query: 2236 TATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFE--FKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPN---PLLHHSCYALLVIYTIYRTVQIVKIEQ-RSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQS 2994
            ++ +DWCE+NY +   IAEF+NTISN L    P   + + R +   F     + +  L++VGIGS  FH TL +  Q+LDEL ++W        V +C   ++    R+L  +    F+ +R    +  ++L   +  + F    I N     L   C ALL+        ++ + +  R   + L S   +T+  F W  D  FC+ L +F             +H  WHI     +Y   +   +      SE P+ 
Sbjct:   14 SSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLW--------VLMC-ALAMWFPRRYLPKI----FRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLI-------AELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFN---------FPYLHCMWHILICLAAYLGCVCFAYFDAA--SEIPEQ 241
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Celegans
Match: W02F12.2 (Alkaline ceramidase [Source:UniProtKB/Swiss-Prot;Acc:O45145])

HSP 1 Score: 55.8398 bits (133), Expect = 4.806e-8
Identity = 65/255 (25.49%), Postives = 113/255 (44.31%), Query Frame = 1 
Query: 2251 WCEE--NYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILV--GIGSWAFHMTLLYPMQLLDELPMIW-CSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPN----PLLHHSCYALLVIYTIYRTVQIVKIEQ-RSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSEN 2985
            WCE    Y+   Y+AEF NT +N  +I  P+  + + R +       + +  L+L   G+ S  +H TL    QL+DEL ++W  +  L+  + + + F     E+F   ++ +R+ +           LI+ ++V    +L  PN     L+  S  A +VI    +   I  IE   SR +AL     + + F FW  D + C         +F L      +HA +H+ +G   Y   I  + I ++ R++ 
Sbjct:   18 WCESAYKYQTLPYVAEFANTCTNLPIIVLPLVNIMLLRRYLHDVNGGLIFPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIITVFLVVYIPVMKWFP----EKFSKRLTLVRWVV-----------LIVTALVSGLCFLE-PNLNAIALMLFSIPAAVVINYEGKQSGIPDIESFPSRILAL-----WGVAFSFWFADRLLC---------DFWLYLGTPYLHALFHLLAGLAGYTIFIMFSMIDIESRTKT 242
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Fly
Match: bwa (gene:FBgn0045064 transcript:FBtr0081331)

HSP 1 Score: 80.4925 bits (197), Expect = 4.443e-16
Identity = 74/260 (28.46%), Postives = 120/260 (46.15%), Query Frame = 1 
Query: 2230 PRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWN--IGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIP--NP--LLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            P ++ +DWCE NY +S  IAEF NT SNFL I  P   + + + +   +     + ++ LI+VG+ S  FH TL    QLLDEL ++W              FS+   +R+         K  +N     + L+++ +I  T      P  N   L+  S   ++++YT  + V     +QR   + + S + + +  F W  D IFC+         +S IN    +H +WHIF    +Y  L+   +  ++  SE PQ
Sbjct:   22 PGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILWV---------FMAAFSLFYPKRYYP-------KFVKNDRKTFSWLMLLSAIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVS----DQRVYRLGIRSTTVWAVAVFCWINDRIFCE--------AWSSIN-FPYLHGFWHIFIFIAAYTVLVLFAYFYVE--SELPQ 250
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Fly
Match: bwa (gene:FBgn0045064 transcript:FBtr0331184)

HSP 1 Score: 80.1073 bits (196), Expect = 8.858e-16
Identity = 74/260 (28.46%), Postives = 120/260 (46.15%), Query Frame = 1 
Query: 2230 PRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWN--IGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIP--NP--LLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            P ++ +DWCE NY +S  IAEF NT SNFL I  P   + + + +   +     + ++ LI+VG+ S  FH TL    QLLDEL ++W              FS+   +R+         K  +N     + L+++ +I  T      P  N   L+  S   ++++YT  + V     +QR   + + S + + +  F W  D IFC+         +S IN    +H +WHIF    +Y  L+   +  ++  SE PQ
Sbjct:   22 PGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILWV---------FMAAFSLFYPKRYYP-------KFVKNDRKTFSWLMLLSAIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVS----DQRVYRLGIRSTTVWAVAVFCWINDRIFCE--------AWSSIN-FPYLHGFWHIFIFIAAYTVLVLFAYFYVE--SELPQ 250
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Match: acer3 (alkaline ceramidase 3 [Source:ZFIN;Acc:ZDB-GENE-091204-155])

HSP 1 Score: 189.119 bits (479), Expect = 1.395e-53
Identity = 103/261 (39.46%), Postives = 145/261 (55.56%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHIS---MKHRSE 2982
            + GYW   T+T+DWCEENY VSYYIAEFWNT+SN +MI  P+     +    +   +   +L L  VGIGSW+FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK ER        LL+ +SI+V+  YL    P+ H   YA+LV + + R+V IV  +    R +   S S + +GF  WNIDN+ C  L++ R     ++  ++Q+HAWWHI +G GSY +++    I    +KHR +
Sbjct:    7 RPGYWGTPTSTLDWCEENYVVSYYIAEFWNTVSNLIMILPPIYGAIQTCRDGLEVRYVWSFLGLAAVGIGSWSFHMTLQYEMQLLDELPMIYSCCVFVYCLYEC-------------------FKQERAVNYFSIILLLTFSIIVSVIYLLWKEPVFHQVMYAVLVAFLVIRSVFIVTWVYPWLRALGFTSLSVFLLGFVLWNIDNMMCDSLRSARQQLPPVVGAVTQLHAWWHILTGLGSYLHILLSLQIRSTYLKHRPK 248
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Match: BX511082.1 (pep chromosome:GRCz11:9:14291932:14297132:1 gene:ENSDARG00000113678.1 transcript:ENSDART00000183119.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX511082.1)

HSP 1 Score: 127.872 bits (320), Expect = 1.173e-34
Identity = 72/224 (32.14%), Postives = 127/224 (56.70%), Query Frame = 2 
Query:  782 QKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF---QKHEAYKRFHG 1435
            ++  ++K +   L  +IIR S S   +    V KK  S+  C DYR +N  T K  + LPL+   + +++ A +F+ +D +  ++ +++++     TAF T  GH+ Y ++PFGL+ APA FQ  +N +L D+   +  VY +DI++ S SL++H++H   V +RL+   L  K  KC +    V ++G+I+S +GM+ DP  V+   ++      +A +RF G
Sbjct:  536 EREAMEKYISDSLAAKIIRPSSSPAGAGFFFVKKKDGSLRPCIDYRGLNAITVKNTYPLPLMSSAFERLQGASFFTKLDLRNAYHLVRIREGDEWKTAFNTPRGHFEYCVLPFGLSNAPAVFQALVNDVLRDMLDQFIYVYLDDILIFSHSLQEHVQHVRRVLQRLLENGLYVKAEKCVFHAQSVPFLGHIVSVEGMRMDPEKVQAVVDWPTPDSRKALQRFLG 759

HSP 2 Score: 40.4318 bits (93), Expect = 1.173e-34
Identity = 26/71 (36.62%), Postives = 36/71 (50.70%), Query Frame = 3 
Query: 1413 KHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            K ++ F+G   +YR FI N S    PLT        F   +    AFD+LK   +  PIL+ PD  +QF+V
Sbjct:  752 KALQRFLGFANFYRRFIRNFSQLAAPLTALTSLKTPFRWSNAAQVAFDRLKSCFVSAPILIAPDPSRQFVV 822
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Match: BX890543.1 (pep chromosome:GRCz11:14:42224893:42231293:-1 gene:ENSDARG00000114583.1 transcript:ENSDART00000185486.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX890543.1)

HSP 1 Score: 123.25 bits (308), Expect = 2.006e-34
Identity = 70/224 (31.25%), Postives = 121/224 (54.02%), Query Frame = 2 
Query:  782 QKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF---QKHEAYKRFHG 1435
            ++  +D+ +   LK  +IR S S   +    V KK  S+  C DYR +N+ T K  + LPL+   +  ++ AK F+ +D +  ++ +++++     TAF T  GH+ Y ++PFGLT APA FQ  +N +L D+   +  VY +DI++ S  L+ H++H   V +RL+   L  K  KC +    + ++G+IIS   ++ DP  +     +      +A +RF G
Sbjct:  525 EREAMDRYINESLKTGLIRPSSSPAGAGFFFVKKKDGSLRPCIDYRGLNDITVKNRYPLPLMSSAFELLQGAKVFTKLDLRNAYHLVRIREGDEWKTAFNTPTGHFEYRVLPFGLTNAPAVFQALVNDVLRDMVNRFVFVYLDDILIFSPCLQIHIQHVRQVLQRLLENQLYVKAEKCVFHAQSIPFLGFIISAGEIQADPCKIRAVAEWPTPDSRKALQRFLG 748

HSP 2 Score: 44.2838 bits (103), Expect = 2.006e-34
Identity = 27/71 (38.03%), Postives = 37/71 (52.11%), Query Frame = 3 
Query: 1413 KHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            K ++ F+G   +YR FI N      PLT      V F    +  EAFD+LK   +  P+L  PD E+QF+V
Sbjct:  741 KALQRFLGFANFYRRFIRNFGQIAAPLTALTSPKVWFKWNSDAQEAFDELKSRFVSAPVLSIPDPEQQFIV 811
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Match: BX511224.1 (pep chromosome:GRCz11:2:18017000:18022765:1 gene:ENSDARG00000113243.1 transcript:ENSDART00000186877.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX511224.1)

HSP 1 Score: 127.487 bits (319), Expect = 5.357e-34
Identity = 72/224 (32.14%), Postives = 127/224 (56.70%), Query Frame = 2 
Query:  782 QKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF---QKHEAYKRFHG 1435
            ++  ++K +   L  +IIR S S   +    V KK  S+  C DYR +N+ T K  + LPL+   + +++ A +F+ +D +  ++ + ++      TAF T  GH+ Y ++PFGL+ APA FQ  +N +L D+   +  VY +DI++ S SL++H++H   V +RL+   L  K  KC +    V+++G+I+S +GM+ DP  ++   N+      +A +RF G
Sbjct:  536 EREAMEKYISDSLAAKIIRPSSSPAGAGFFFVKKKDGSLRPCIDYRGLNSITVKNTYPLPLMSSAFERLQGANFFTKLDLRNAYHLVCIRPGDEWKTAFNTPRGHFEYCVLPFGLSNAPAVFQALVNDVLRDMIDQFIYVYLDDILIFSHSLQEHIQHVRRVLQRLLENGLYVKAEKCVFHAQSVQFLGHIVSVEGMRMDPEKIQAVVNWPTPDSRKALQRFLG 759

HSP 2 Score: 38.5058 bits (88), Expect = 5.357e-34
Identity = 26/71 (36.62%), Postives = 34/71 (47.89%), Query Frame = 3 
Query: 1413 KHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            K ++ F+G   +YR FI N S    PLT        F        AF KLK   +  PIL+ PD  +QF+V
Sbjct:  752 KALQRFLGFANFYRRFIHNFSQLAAPLTSLTSSKTPFRWSSAAEAAFSKLKGCFVSAPILIAPDPSRQFVV 822
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Match: CR855320.1 (pep chromosome:GRCz11:1:7956030:7961696:1 gene:ENSDARG00000099359.2 transcript:ENSDART00000159655.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR855320.1)

HSP 1 Score: 125.561 bits (314), Expect = 1.701e-33
Identity = 72/229 (31.44%), Postives = 128/229 (55.90%), Query Frame = 2 
Query:  767 TLRPYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF---QKHEAYKRFHG 1435
            +L   ++  + K +   L  +IIR S S   +    V KK  S+  C DYR +NN T K  + LPL+   + +++ A +F+ +D +  ++ ++++      +AF T  GH+ Y ++PFGL+ APA FQ  +N +L D+   +  VY +DI++ S SL++H++H   V +RL+   L  K  KC +    V ++G+I+S +G++ DP  ++   N+      +A +RF G
Sbjct:  533 SLSAPEREAMGKYISDSLAAKIIRPSSSPAGAGFFFVKKKDGSLRPCIDYRGLNNITVKNTYPLPLMSSAFERLQGANFFTKLDLRNAYHLVRIRAGDEWKSAFNTPRGHFEYCVLPFGLSNAPAVFQAFVNDVLRDMIDQFIYVYLDDILIFSHSLQEHVQHIRRVLQRLLENGLYVKAEKCVFHAQSVPFLGHIVSVEGLRMDPEKIKAVVNWPTPDSRKALQRFLG 761

HSP 2 Score: 38.5058 bits (88), Expect = 1.701e-33
Identity = 26/71 (36.62%), Postives = 34/71 (47.89%), Query Frame = 3 
Query: 1413 KHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            K ++ F+G   +YR FI N S    PLT        F        AF KLK   +  PIL+ PD  +QF+V
Sbjct:  754 KALQRFLGFANFYRRFIRNFSQLAAPLTALTSSKTPFRWSSAAEAAFSKLKGCFVSAPILITPDPSRQFVV 824
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Match: tspyl2 (TSPY-like 2 [Source:Xenbase;Acc:XB-GENE-1016996])

HSP 1 Score: 172.555 bits (436), Expect = 1.231e-47
Identity = 105/268 (39.18%), Postives = 148/268 (55.22%), Query Frame = 1 
Query: 2194 LSGLLMKVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATN-LKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            ++  L + GYW P T+T++WCEENY VS+YIAEFWNT+SN +MI  P+     +    +   + + +L L  VG+GSW FHMTL Y MQLLDELPMI+           C  F   L E F N          RN+ N L   LLI++S++VT  YL    P+ H   Y LLV + + R+V IV  +    R +A  S   + +GF  WN+DNIFC   +  R     ++  ++Q HAWWHI +G GSY +++F  +    +    P+
Sbjct:    1 MAPALDRPGYWGPPTSTLEWCEENYAVSFYIAEFWNTVSNLIMILPPIYGAIQTVRDGLETRYLVSFLGLAAVGLGSWCFHMTLQYEMQLLDELPMIYS----------CSVFVYCLYECFKN----------RNSYNYLLLILLILFSLIVTTVYLRWKEPVFHQVMYGLLVSFLVLRSVYIVTWVYPWLRGLAYTSLGVFLLGFVLWNVDNIFCSTWREVRQKVPPVVGAVTQFHAWWHILTGLGSYLHILFSLYTRTLYLKYRPK 248
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Match: anxa6 (annexin A6 [Source:Xenbase;Acc:XB-GENE-989741])

HSP 1 Score: 147.902 bits (372), Expect = 2.824e-41
Identity = 82/236 (34.75%), Postives = 132/236 (55.93%), Query Frame = 2 
Query:  713 GKTNLLEHEIVLTNSKPI---------TLRPYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLL-YMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVH-YAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVE 1387
            G+T+  EH++      PI          +RP  K+Q+D+    ML   +I  S S + S ++ V KK  S   C DYR +N+ T  + + +P +  +  ++ NAKY + +D  +G++QI L       +AF T  G Y + +MPFG+  APATFQR +N +L  +  +A  Y +DI V S + E+HL+H + VF ++ +A L  KP KC    ++V+Y+G+ +    ++PDPA VE
Sbjct:  321 GRTHWAEHKVDTGTQLPIRSPAYRVAEAVRPEMKSQIDE----MLAFGVITPSHSPWASPVVLVPKKDGSTRFCVDYRRLNDVTTTDAYPMPRVDELLDRLGNAKYLTTLDLSRGYWQIPLAPSAQEKSAFLTPFGLYQFTVMPFGMRNAPATFQRLVNRLLEGMQDFAQAYLDDIAVFSQTWEEHLQHLQRVFAQIQDAGLTLKPEKCHLAMAEVQYLGHRVGGGQLRPDPAKVE 552

HSP 2 Score: 43.1282 bits (100), Expect = 2.824e-41
Identity = 29/80 (36.25%), Postives = 40/80 (50.00%), Query Frame = 3 
Query: 1398 ISKNMKHIKGFMGLFGYYRTFIINLSATPLPLT--**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMVIT 1631
            I K  K +  F+G  GYYR FI N S    PLT      ++   V   E   A + LK+ L   P+L  PDF ++F++ T
Sbjct:  559 IPKTQKQVLAFLGTSGYYRKFIPNYSTVAKPLTDLTSRQRSRTIVWTPECESAMNALKQALASSPVLAAPDFSRRFILQT 638
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Match: tspyl2 (TSPY-like 2 [Source:Xenbase;Acc:XB-GENE-1016996])

HSP 1 Score: 139.813 bits (351), Expect = 1.683e-36
Identity = 91/267 (34.08%), Postives = 133/267 (49.81%), Query Frame = 1 
Query: 2194 LSGLLMKVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            ++  L + GYW P T+T++WCEENY VS+YIAEFWNT+SN +MI  P+     +    +   + + +L L  VG+GSW FHMTL Y MQL        CS  L            S  E F N          RN+ N    +L+I   ++  T   +         Y LLV + + R+V IV  +    R +A  S   + +GF  WN+DNIFC   +  R     ++  ++Q HAWWHI +G GSY +++F  +    +    P+
Sbjct:    1 MAPALDRPGYWGPPTSTLEWCEENYAVSFYIAEFWNTVSNLIMILPPIYGAIQTVRDGLETRYLVSFLGLAAVGLGSWCFHMTLQYEMQLF-------CSLFL------------SRYECFKN----------RNSYNYLLLILLILFSLIVTTVSVM---------YGLLVSFLVLRSVYIVTWVYPWLRGLAYTSLGVFLLGFVLWNVDNIFCSTWREVRQKVPPVVGAVTQFHAWWHILTGLGSYLHILFSLYTRTLYLKYRPK 229
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Match: ENSXETT00000006041.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:6:37317867:37322724:1 gene:ENSXETG00000003070.1 transcript:ENSXETT00000006041.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 145.206 bits (365), Expect = 1.652e-34
Identity = 80/249 (32.13%), Postives = 137/249 (55.02%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPITLR-----PYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQK 1408
            +F++++ D+G +   +H+I L   KP   R     P     + K ++ +    II+ S+S + S ++ V KK  S+ +C DYRT+N  T  + +  P +      +  +K+FSV+D + G+YQ+ +  +    TAF   +G + +  MP GL  APATFQR M   + D+H    +VY +D++V   +LE+H +    VF RL    LK  P KC++ +  V YVG+++S +G+  DP+ +E   ++ K
Sbjct:  301 LFSRNDLDMGCSTSTKHKIRLREDKPFRERSRRIAPGDLEDLRKHLEELKAAGIIKESRSPYASPIVVVRKKNGSIRMCVDYRTLNQRTIPDQYTTPRIEDALNCLVGSKWFSVLDLRSGYYQLPMHPEDKEKTAFICPLGFFEFNRMPQGLCGAPATFQRLMERTVGDMHLLEVLVYLDDLIVFGRTLEEHEQRLLKVFDRLEKEGLKLSPEKCQFCQPSVNYVGHVVSAEGIATDPSKIEAVSSWPK 549
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Match: alkbh5 (alkB homolog 5, RNA demethylase [Source:Xenbase;Acc:XB-GENE-987580])

HSP 1 Score: 129.798 bits (325), Expect = 9.550e-31
Identity = 74/258 (28.68%), Postives = 133/258 (51.55%), Query Frame = 2 
Query:  683 QVFAKHEYDLGKTNLLEHEIVLTNSKPITLRPYQ-----KNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLL-YMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMD-VHYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQKHEAYKRFHG 1435
            Q+F+      G T +++H+I+      + +RPY+     +  V  ++K ML+ ++I  S S + S ++ V K   S+  C D+R +N  +  + + +P +  +  ++  A+Y + +D  KG++Q+ L +     TAF T  G + Y  +PFGL  APATFQR M+ +L     YA  Y +D+V+ S   E HL   + V   +  A L   P KC     + +Y+GY+I +  +KP  + +E  + + +  + K+   
Sbjct:  212 QIFSDQP---GLTEMIKHDIITGPGVKVNVRPYRIPEARRQAVAGEIKRMLELDVIEESHSEWSSPIVLVPKPDGSIRFCNDFRKLNEVSKFDAYPMPRVDELIERLGQARYITTLDLTKGYWQVPLTEGAKEKTAFSTPEGQWQYKRLPFGLHGAPATFQRMMDRILKPHRGYASAYLDDVVIFSPDWESHLPRVQAVLDSIWKAGLTANPKKCAMGLEEARYLGYVIGRGVVKPQVSKIEGIQQWPRPNSKKQVRA 466
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Match: Acer3 (alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1913440])

HSP 1 Score: 182.57 bits (462), Expect = 3.003e-51
Identity = 102/272 (37.50%), Postives = 149/272 (54.78%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            + GYW P T+T+DWCEENY V+ ++AEFWNT+SN +MI  P+          +   +   YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C +     T+  +NY   + F             L +YS+ VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S + + +GF  WNIDNIFC  L+NFR     ++   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P V
Sbjct:    7 RKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFK-----TKSSINY--HLLFT------------LFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLTVFLLGFLLWNIDNIFCDSLRNFRKRVPPVLGVTTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPAV 259
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Match: Acer3 (alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1913440])

HSP 1 Score: 129.798 bits (325), Expect = 2.280e-33
Identity = 75/213 (35.21%), Postives = 109/213 (51.17%), Query Frame = 1 
Query: 2389 CYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
             YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK + +        L +YS+ VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S + + +GF  WNIDNIFC  L+NFR     ++   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P V
Sbjct:   24 AYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFEC-------------------FKTKSSINYHLLFTLFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLTVFLLGFLLWNIDNIFCDSLRNFRKRVPPVLGVTTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPAV 217
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Match: Acer3 (alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1913440])

HSP 1 Score: 123.635 bits (309), Expect = 7.989e-32
Identity = 70/177 (39.55%), Postives = 100/177 (56.50%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIV 2742
            + GYW P T+T+DWCEENY V+ ++AEFWNT+SN +MI  P+          +   +   YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C +     T+  +NY   + F             L +YS+ VT  YL +  P+ H   Y +LV   + R++ IV
Sbjct:    7 RKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFK-----TKSSINY--HLLFT------------LFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIV 164
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Match: Acer3 (alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1913440])

HSP 1 Score: 90.5077 bits (223), Expect = 2.313e-21
Identity = 41/84 (48.81%), Postives = 56/84 (66.67%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQL 2463
            + GYW P T+T+DWCEENY V+ ++AEFWNT+SN +MI  P+          +   +   YL+L +VG+GSW FHMTL Y MQ+
Sbjct:    7 RKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQV 90
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Match: Acer2 (alkaline ceramidase 2 [Source:MGI Symbol;Acc:MGI:1920932])

HSP 1 Score: 77.0258 bits (188), Expect = 7.393e-15
Identity = 71/259 (27.41%), Postives = 112/259 (43.24%), Query Frame = 1 
Query: 2236 TATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFE--FKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPN---PLLHHSCYALLVIYTIYRTVQIVKIEQ-RSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQS 2994
            ++ +DWCE+NY +   IAEF+NTISN L    P   + + R +   F     + +  L++VGIGS  FH TL +  Q+LDEL ++W        V +C   ++    R+L  +    F+ +R        +L   +  + F    I N    +L   C ALLV        ++ + +  R   + L S   +T+  F W  D  FC+ L +F             +H  WHI     SY   +   +      SE P+ 
Sbjct:   14 SSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAILW--------VLMC-ALAMWFPRRYLPKI----FRNDRGRFKAVVCVLSAITTCLAFIKPAINNISLMILGLPCTALLV-------AELKRCDNVRVFKLGLFSGLWWTLALFCWISDQAFCELLSSFH---------FPYLHCVWHILICLASYLGCVCFAYFDAA--SEIPEQ 241
[Close]
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Match: sp|Q9NUN7|ACER3_HUMAN (Alkaline ceramidase 3 OS=Homo sapiens OX=9606 GN=ACER3 PE=1 SV=3)

HSP 1 Score: 192.2 bits (487), Expect = 8.838e-54
Identity = 103/272 (37.87%), Postives = 152/272 (55.88%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            + GYW P T+T+DWCEENY V++YIAEFWNT+SN +MI  P+     S    +   +   YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C                   FK++ +        L+++S++VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S   + +GF FWNIDNIFC+ L+NFR     +I   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P++
Sbjct:    7 REGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFEC-------------------FKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVI 259
[Close]
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Match: sp|Q9D099|ACER3_MOUSE (Alkaline ceramidase 3 OS=Mus musculus OX=10090 GN=Acer3 PE=1 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 2.100e-50
Identity = 102/272 (37.50%), Postives = 149/272 (54.78%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIV 3024
            + GYW P T+T+DWCEENY V+ ++AEFWNT+SN +MI  P+          +   +   YL+L +VG+GSW FHMTL Y MQLLDELPMI+  C+ +  +  C +     T+  +NY   + F             L +YS+ VT  YL +  P+ H   Y +LV   + R++ IV  +    R +   S + + +GF  WNIDNIFC  L+NFR     ++   +Q HAWWHI +G GSY +++F  +    +    P+   +  I P V
Sbjct:    7 RKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFK-----TKSSINY--HLLFT------------LFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLTVFLLGFLLWNIDNIFCDSLRNFRKRVPPVLGVTTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPAV 259
[Close]
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Match: sp|P20825|POL2_DROME (Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster OX=7227 GN=pol PE=4 SV=1)

HSP 1 Score: 148.288 bits (373), Expect = 9.737e-42
Identity = 92/250 (36.80%), Postives = 145/250 (58.00%), Query Frame = 2 
Query:  689 FAKHEYDLGK----TNLLEHEIVLTNSKPITLRPYQKNQ-----VDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCK-----DYRTVNNDTFKENHQLP-LLYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVE 1387
            F   EY  G+    TN ++H +  T++ PI  + Y   Q     V+ QV+ ML   +IR S S + S    V KK  +    K     DYR +N  T  + + +P +  + GK+   +YF+ +D  KGF+QI++ +++I  TAF T  GHY Y  MPFGL  APATFQR MN +L  +   + +VY +DI++ S+SL +HL   + VF +L +ANLK +  KC++ + +  ++G+I++ DG+KP+P  V+
Sbjct:  178 FRNLEYKEGEKLTFTNTIKHVLNTTHNSPIYSKQYPLAQTHEIEVENQVQEMLNQGLIRESNSPYNSPTWVVPKKPDASGANKYRVVIDYRKLNEITIPDRYPIPNMDEILGKLGKCQYFTTIDLAKGFHQIEMDEESISKTAFSTKSGHYEYLRMPFGLRNAPATFQRCMNNILRPLLNKHCLVYLDDIIIFSTSLTEHLNSIQLVFTKLADANLKLQLDKCEFLKKEANFLGHIVTPDGIKPNPIKVK 427

HSP 2 Score: 46.2098 bits (108), Expect = 9.737e-42
Identity = 34/74 (45.95%), Postives = 44/74 (59.46%), Query Frame = 3 
Query: 1413 KHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKF-V*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMVIT 1631
            K I+ F+GL GYYR FI N +    P+T    K  K      E  EAF+KLK L++  PIL  PDFEK+F++ T
Sbjct:  439 KEIRAFLGLTGYYRKFIPNYADIAKPMTSCLKKRTKIDTQKLEYIEAFEKLKALIIRDPILQLPDFEKKFVLTT 512
[Close]
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Match: sp|P04323|POL3_DROME (Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster OX=7227 GN=pol PE=4 SV=1)

HSP 1 Score: 145.591 bits (366), Expect = 4.667e-34
Identity = 80/214 (37.38%), Postives = 130/214 (60.75%), Query Frame = 2 
Query:  785 KNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCK-----DYRTVNNDTFKENHQLP-LLYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDV--HYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            + +V+ Q++ ML   IIR S S + S +  V KK  +    K     DYR +N  T  + H +P +  + GK+    YF+ +D  KGF+QI++  +++  TAF T  GHY Y  MPFGL  APATFQR MN +L  +   + +VY +DI+V S+SL++HL+    VF++L  ANLK +  KC++ + +  ++G++++ DG+KP+P  +E  + +
Sbjct:  220 EQEVESQIQDMLNQGIIRTSNSPYNSPIWVVPKKQDASGKQKFRIVIDYRKLNEITVGDRHPIPNMDEILGKLGRCNYFTTIDLAKGFHQIEMDPESVSKTAFSTKHGHYEYLRMPFGLKNAPATFQRCMNDILRPLLNKHCLVYLDDIIVFSTSLDEHLQSLGLVFEKLAKANLKLQLDKCEFLKQETTFLGHVLTPDGIKPNPEKIEAIQKY 433
[Close]
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Match: sp|Q7LHG5|YI31B_YEAST (Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY3B-I PE=1 SV=2)

HSP 1 Score: 126.331 bits (316), Expect = 5.897e-28
Identity = 88/254 (34.65%), Postives = 133/254 (52.36%), Query Frame = 2 
Query:  770 LRPY---QKNQ--VDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLL-YMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQKHEAYK---RFHGPIWLLQNVYHK--PFCNTITTYI 1498
            L+PY   +KN+  ++K V+ +L ++ I  SKS   S ++ V KK  +  LC DYRT+N  T  +   LP +  +  +I NA+ F+ +D   G++QI ++      TAF T  G Y Y +MPFGL  AP+TF R M     D+ +  VY +DI++ S S E+H +H + V +RL N NL  K  KCK+   + +++GY I    + P         +F   +  K   RF G I    N Y +  P C+ I   I
Sbjct:  625 LQPYHVTEKNEQEINKIVQKLLDNKFIVPSKSPCSSPVVLVPKKDGTFRLCVDYRTLNKATISDPFPLPRIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYTVMPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDTVLERLKNENLIVKKKKCKFASEETEFLGYSIGIQKIAPLQHKCAAIRDFPTPKTVKQAQRFLGMI----NYYRRFIPNCSKIAQPI 874
[Close]
BLAST of Alkaline ceramidase vs. TrEMBL
Match: A0A355ABF2 (Uncharacterized protein OS=Flavobacteriaceae bacterium OX=1871037 GN=DDZ39_05755 PE=4 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 4.167e-59
Identity = 151/459 (32.90%), Postives = 251/459 (54.68%), Query Frame = 2 
Query:   89 LSCQIKLCDQELHHYILVMRTLAAEYLLGKYPKEAQKGGL-DCATGTLV*LVGKKRKINNDDRVFVNLTMTIPARFETVCFVALSKQSEEEVLLEPDEGFSLKYDLSITYSVAKVENGRIPIRDSQLKN*TIKTIPRDQN*KSIKTRRIRTNRKWRIGIVSHNR*IVVR**AL*CFHSK*QNLHPEKQYRS*QVGEKI*QVFAKHEYDLGKTNLLEHEIVLTNSKPITLRPYQ-----KNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLL-YMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQKH---EAYKRFHG 1435
            L C++ +C+Q++   ++V++ L    ++G       KG + D +   L  L     +I ++  ++V    TIP   E V  + +    ++ V+ EP++ F+    LS+  +V   +N  IP+R     N  I+ + + Q+  +I            I +V  N   V        F      L+ E+      + +K  +VFA  ++DLGKTN+++H I L    PI  RPY+     K ++ KQV+ M  +++IR S S + S ++ V KK  ++  C DYR +N  T K+ + LP +  M  K+ N+K+F+ +D Q G++QI++ ++    TAF T  G Y + ++PFGLT APATFQR M+ +LMD  +A+VY +DI++ S   ++HL     V +RL  A LK KP KC+W +S V ++G+++S +G+KPDP NVEK +NF+K    +  +RF G
Sbjct: 1142 LLCELTICNQKISSELVVVKNLPYPCIIGMSTLSKLKGIVFDPSCNRLKTL---NNEIIDNMNIYVTEDTTIPKWNEVVMPMQIHCNDDKTVIFEPNDIFADTNCLSVATTVTNTDNSTIPVRFVNYSNDNIQ-LQQGQHIGTIH----------EIDVVEVNVAKVFEGGMPPNFPF--DYLNNEQNQAMENIFQKYSKVFATDDFDLGKTNIIKHFIPLDKDNPIKQRPYKAAYALKGEIKKQVEDMKHNKVIRNSFSPWASPIVMVKKKDGTMRFCVDYRKLNTVTRKDTYPLPRIDEMLDKLNNSKFFTSLDLQSGYWQIEISEEDKYKTAFTTGEGLYEFNVLPFGLTGAPATFQRCMSHILMDASHAMVYIDDILIYSIDFDEHLHDITMVLQRLELAGLKIKPRKCEWAKSMVTFLGHLVSSEGIKPDPKNVEKIKNFEKPVKVKGIQRFLG 1584

HSP 2 Score: 42.743 bits (99), Expect = 4.167e-59
Identity = 27/74 (36.49%), Postives = 43/74 (58.11%), Query Frame = 3 
Query: 1410 MKHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMVIT 1631
            +K I+ F+G+ GYYR FI N +    PL     KN   +   +  E+F++LK  L+  P+L +PD  K F+++T
Sbjct: 1576 VKGIQRFLGMAGYYRKFIPNFAKIASPLFDLTKKNDNTLWTEKHQESFEELKNRLIHFPVLRFPDMNKDFIIMT 1649
[Close]
BLAST of Alkaline ceramidase vs. TrEMBL
Match: A0A1W3JTM7 (Alkaline ceramidase OS=Ciona intestinalis OX=7719 GN=LOC100181659 PE=3 SV=1)

HSP 1 Score: 204.912 bits (520), Expect = 9.337e-56
Identity = 113/274 (41.24%), Postives = 161/274 (58.76%), Query Frame = 1 
Query: 2218 GYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFP-VCFLWISRNWNIGFEFK--MCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFR-SSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVR 3027
            G+W   TAT+DWCEENY  + YIAEFWNT SN +MI  P VC L+   NWN G E +  +  LS++ VG+GSW FHMTL Y MQLLDELPMI+ +C+LL  +      +  + +R  NY+                  LI  S+ VT  YL   +P+ H   YA+LV + +Y  +  +K     + + L S   Y  GFF WNIDNIFC +L+N R SS   L++  +Q+HAWWHIF+G+G+Y +++F ++  + H     +   +GY+ P ++
Sbjct:   11 GFWGKPTATLDWCEENYVTNKYIAEFWNTTSNVIMILPPLVCALY---NWNKGLEMRYILANLSILAVGVGSWMFHMTLWYEMQLLDELPMIYGTCVLLYAL---HHHASPVKKRSYNYIIS----------------LIFVSVAVTVVYLQWKHPIFHQVSYAVLVFFLLYEAILALKNYPAIKAVGLASLCFYLFGFFLWNIDNIFCSHLRNARASSNNPLLSVATQLHAWWHIFTGYGTYLHILFSSYARLLHLKRECKVTKLGYVWPYLK 262
[Close]
BLAST of Alkaline ceramidase vs. TrEMBL
Match: A0A1S3HRJ7 (Alkaline ceramidase OS=Lingula unguis OX=7574 GN=LOC106156791 PE=3 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 3.991e-54
Identity = 102/273 (37.36%), Postives = 158/273 (57.88%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRP 3030
            K+G+W P T+T+DWCE NYEVS+YIAEFWNTISN +MI  P+  L  +           C++ L+LVG+GSW FHMTLLY  QLLDE+PMIW +C L+ T+     + +    +  N + Q               +L++Y + VT  Y    N +     Y ++V   +  ++Q+ +  + S  + ++   TY  GF  WN+DN++C+ L++ R    + + PL+QMHAWWH+ +G G+Y  +I+  H  + +  +NP   + G ++PIVRP
Sbjct:    7 KIGFWGPVTSTVDWCETNYEVSFYIAEFWNTISNVMMILPPLVGLLFAVKDAAEGRIVGCHIGLMLVGMGSWCFHMTLLYSSQLLDEMPMIWGTCFLIYTL-----YEVGSPPKSHNRILQC--------------VLLLYCLFVTVVYTTTHNVIFFQVSYGIMVFAIVACSIQVYRNFEHSNFLLVMGILTYGTGFLLWNVDNLYCENLRHLRQWLPAALRPLTQMHAWWHVGAGIGTYTSIIYAAHARLVYLKKNP--VIEGSLLPIVRP 258
[Close]
BLAST of Alkaline ceramidase vs. TrEMBL
Match: A0A5E4N8W8 (Alkaline ceramidase OS=Cinara cedri OX=506608 GN=CINCED_3A012075 PE=3 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 9.062e-54
Identity = 103/262 (39.31%), Postives = 150/262 (57.25%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFT--YLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQR---SRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSE 2982
            + GYW   TATIDWCE+NYEV+YY+AE WNT+SN +MI  P+  +   +       F  CYL +++VG GSWAFHMTLLY MQL DELPM+W +C  +                    +S ++  M+      K  LL++  I V F   YL  P PLL H CY +LV  ++ + V+++ +E +    ++I +++   Y  GFF WNIDNIFCK L   R      + P++Q+H WWH+F+G+G Y  ++F  H +  +  +
Sbjct:    8 QTGYWGKPTATIDWCEKNYEVNYYVAEMWNTVSNLMMIIPPLWGILDMKKQKFARRFLFCYLFIMVVGFGSWAFHMTLLYEMQLFDELPMVWGTCYCVYC------------------LSIVKHDMKSKVIPNKLLLLVLMIISVGFAIIYLAWPQPLLQHFCYGILVAISLAQEVKLI-LEFKCGVCKHIFIVALMLYLFGFFLWNIDNIFCKNLMTLREQIPMFLQPVTQLHGWWHVFAGYGVYIQVLFCIHSTYDYHKK 250
[Close]
BLAST of Alkaline ceramidase vs. TrEMBL
Match: A0A2C9KPP4 (Alkaline ceramidase OS=Biomphalaria glabrata OX=6526 GN=106072459 PE=3 SV=1)

HSP 1 Score: 198.364 bits (503), Expect = 2.147e-53
Identity = 106/259 (40.93%), Postives = 148/259 (57.14%), Query Frame = 1 
Query: 2218 GYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINP-LSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            G+W   T+T+DWCEENY VSYY+AEFWNT+SN +MI  P   +++         F   +L+L +VG GSW FHMTL Y MQL+DELPMIW +  L+ ++ +                     K       L+ N LIIYSIVVT  Y+ + +P+ H   Y L+V   I    +I+   + SR + L S  TY +GFF WN+DN+FC +L++ RS     ++  L + HAWWHIF+G G+Y  L+F  H      +ENP+
Sbjct:    7 GFWGKETSTLDWCEENYVVSYYVAEFWNTVSNVIMIFAPFVMVFVGYTEKHEKRFLYSFLALTVVGTGSWFFHMTLKYSMQLMDELPMIWGTSFLVYSLYMMDS------------------KPNEECLPLR-NGLIIYSIVVTLVYILVKDPIFHQVAYGLMVASIIIMASRILLTIKCSRKLYLTSLFTYGLGFFLWNVDNVFCSHLRSIRSHPVGQVSGMLFECHAWWHIFAGTGTYLSLLFGVHTRYVFLNENPK 246
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Match: acer3 (alkaline ceramidase 3 [Source:ZFIN;Acc:ZDB-GENE-091204-155])

HSP 1 Score: 164.466 bits (415), Expect = 2.087e-45
Identity = 99/248 (39.92%), Postives = 137/248 (55.24%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVC-FLWISRNWNIGFEFKMCYLSLIL-VGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIF 2949
            + GYW   T+T+DWCEENY VS+YIAEF NT+SN +MI  P+   L  S+N   G E +  +  L L VG+GSW+FHMTL Y MQLLDELPMI+  C+ +   E                     FK +         LL+++SI+VT        P+ H   Y +LV   ++R V IV +    R +   S + + +GF  WNIDNIFC  L   R S   ++  ++Q+HAWWHI +G GSY +++ 
Sbjct:    7 RQGYWGSPTSTLDWCEENYVVSFYIAEF-NTVSNLIMIIPPILGALQTSKN---GLEIRYVWAYLGLAVGVGSWSFHMTLQYEMQLLDELPMIYSCCVFVYCYEC--------------------FKQKNGINYFLIALLLLFSIIVTVW----KEPVFHQVMYGMLVACLVFRCVFIVTVYPWLRALCYTSLTVFLLGFVLWNIDNIFCDSLAT-RQSLPPVVGAVTQLHAWWHILTGLGSYLHILL 225
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Match: ENSAMXT00000048130.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000027.1:9314169:9318317:-1 gene:ENSAMXG00000039110.1 transcript:ENSAMXT00000048130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 162.54 bits (410), Expect = 1.605e-43
Identity = 90/248 (36.29%), Postives = 147/248 (59.27%), Query Frame = 2 
Query:  683 QVFAKHEYDLGKTNLLEHEIVLTNSKPITLR-----PYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLP-LLYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            +VFA H+ D G TN ++H I L++  P   R     P   + V + ++ +L+  +IR S+S+F S ++ V KK   V LC DYR +N  T K+ + LP L   +  +  +K+FSV+D + G+YQI+L++     TAF   +G + +  MP G+T AP+TFQR M   + D++    +V+ +D+++ S +LE+H E    V +RL    LK  P KCK+ +  V+Y+G+I+S DG+K DP  +   +N+
Sbjct:  163 EVFAHHDLDFGHTNQVKHRIKLSDETPFKQRARPIHPQDFDAVKRHLEELLESGVIRESESSFSSPIVVVRKKNGEVRLCVDYRKLNLQTVKDAYALPHLEETFSVLTGSKWFSVLDLKSGYYQIELEEADKHKTAFVCPLGFWEWNRMPQGITNAPSTFQRLMEKCMSDLNLREVIVFLDDLIIFSETLEEHEERLFKVLQRLKEYGLKLSPEKCKFFQKSVRYLGHIVSSDGVKTDPEKIAVLKNW 410

HSP 2 Score: 35.039 bits (79), Expect = 1.605e-43
Identity = 14/30 (46.67%), Postives = 19/30 (63.33%), Query Frame = 3 
Query: 1404 KNMKHIKGFMGLFGYYRTFIINLSATPLPL 1493
            KN+K ++ F+G  GYYR FI + S    PL
Sbjct:  414 KNLKELRSFLGFAGYYRRFIRDFSKIVKPL 443
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Match: ENSAMXT00000041754.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001938.1:55959:59870:1 gene:ENSAMXG00000043385.1 transcript:ENSAMXT00000041754.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 169.474 bits (428), Expect = 2.818e-43
Identity = 93/242 (38.43%), Postives = 142/242 (58.68%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPIT-----LRPYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHYAVV--YFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVE 1387
            +FAK E DLG T+L+ HEI L +  P+      + P Q + V   ++ +L   +IR S S F S ++ V KK  S+ LC DYR +N  T ++++ LP +      +  AK+FS +D   G+ Q+ +++     TAF T  G + +  MPFGL  AP TFQR M  +  D  Y  V  Y +D++V S ++E+HLE  E+VF RL   NLK K SKC++ + +V Y+G+++S +G+  DPA +E
Sbjct:  282 IFAKSEGDLGCTSLISHEIPLLDEVPVRQPYRRIPPSQYSTVKAHIQQLLDSRVIRESSSPFSSPIVLVTKKDGSLRLCVDYRQLNAKTRRDSYPLPRIEESLDALCGAKWFSTLDLASGYNQVPVEEKDKSKTAFCTPFGLFEFNRMPFGLCNAPGTFQRLMERIFGDCRYQSVLLYLDDVIVFSQTVEEHLERLEEVFSRLQKQNLKVKLSKCQFFQHQVSYLGHVVSAEGVTTDPAKIE 523

HSP 2 Score: 27.335 bits (59), Expect = 2.818e-43
Identity = 25/93 (26.88%), Postives = 35/93 (37.63%), Query Frame = 3 
Query: 1407 NMKHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*G--------------------HE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            ++  ++ F+G   YYR F+   S    PL        + V G                     E  +AF  LK  L   P+L Y DF K F+V
Sbjct:  533 HLAELRSFLGFASYYRRFVEGFSKLAAPLH-------RLVGGLSGPRRKGKTPKTSLAAFWDAECEQAFQSLKDRLTSTPVLAYADFNKPFIV 618
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Match: ENSAMXT00000052892.1 (pep primary_assembly:Astyanax_mexicanus-2.0:15:1687614:1691096:-1 gene:ENSAMXG00000041369.1 transcript:ENSAMXT00000052892.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 160.614 bits (405), Expect = 3.737e-43
Identity = 88/249 (35.34%), Postives = 142/249 (57.03%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPITLR-----PYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQK 1408
            VF+ +E+D+G    +EH I L++S+P   R     P     V + ++ +L   II+ S+S + S ++   KK  SV +C DYRT+NN T  + + +P +      +  +++FSV+D + G+YQI + ++    TAF   +G + +  MP G+T APATFQR M   + D+H    +VY +DI+V   SLE+H E    V  RL    LK    KC++ + +VKYVG+++SKDG+  DP  V     +++
Sbjct:   50 VFSINEWDVGLAKGVEHHIRLSDSRPFRERSRRIAPADVEDVRRHIQELLAAGIIKESRSPYASPIVIARKKNGSVRMCIDYRTLNNRTIPDQYTMPRIDDALDCLSGSRWFSVLDLRSGYYQIAMSEEDKEKTAFICPLGFFQFERMPQGITGAPATFQRLMEKAVGDMHLLQVIVYLDDIIVFGKSLEEHEERLLKVLDRLEEVGLKISIDKCQFCQPEVKYVGHVVSKDGISTDPDKVSAVTQWKQ 298

HSP 2 Score: 36.1946 bits (82), Expect = 3.737e-43
Identity = 15/30 (50.00%), Postives = 20/30 (66.67%), Query Frame = 3 
Query: 1407 NMKHIKGFMGLFGYYRTFIINLSATPLPLT 1496
            ++K ++ F+G  GYYR FI N SA   PLT
Sbjct:  301 DLKSLRSFLGFCGYYRRFIANYSAIVRPLT 330
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Match: ENSAMXT00000037150.1 (pep primary_assembly:Astyanax_mexicanus-2.0:10:22265216:22268869:1 gene:ENSAMXG00000033912.1 transcript:ENSAMXT00000037150.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 166.392 bits (420), Expect = 1.615e-42
Identity = 92/249 (36.95%), Postives = 143/249 (57.43%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPIT-----LRPYQKNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENFQK 1408
            +FA+ E DLG T LL HEI L +  P+      + P Q   V   ++ +L  ++IR S S + S ++ V KK  S+ LC DYR +N  T ++ + LP +      +  AK+FS +D   G+ Q+ + +     TAF T  G + +  MPFGL  APATFQR M  M  D  Y   ++Y +D++V SSS+E+HLE   +VF RL    LK K SKC + + +V Y+G+++S++G+  DPA ++    +++
Sbjct:  298 IFAQTEGDLGCTTLLTHEIPLLDEVPVRQPYRRIPPSQYEAVKLHIQQLLDSKVIRNSASPYSSPIVLVTKKDGSLRLCVDYRQLNAKTRRDAYPLPRIEESLDALAGAKWFSTLDLASGYNQVPVSEKDRYKTAFCTPFGLFEFNRMPFGLCNAPATFQRLMERMFGDCRYQSVLLYLDDVIVFSSSVEQHLERLAEVFSRLQKQGLKVKLSKCHFFQPQVNYLGHVVSREGVATDPAKIDAVRGWRR 546

HSP 2 Score: 28.1054 bits (61), Expect = 1.615e-42
Identity = 25/98 (25.51%), Postives = 38/98 (38.78%), Query Frame = 3 
Query: 1395 RISKNMKHIKGFMGLFGYYRTFIINLS---------------------ATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMV 1625
            R   ++  ++ F+G   YYR F+   S                       P+PL    D+  +        +AF  LK+ L   P+L Y DF K F+V
Sbjct:  545 RRPSHLAELRSFLGFASYYRRFVEGFSKLAAPLHQLVGKLGGARRKGKTLPVPLAASWDERCE--------KAFQSLKERLTSAPVLAYADFSKPFIV 634
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Sea Lamprey
Match: acer2 (alkaline ceramidase 2 [Source:ZFIN;Acc:ZDB-GENE-121026-1])

HSP 1 Score: 75.0998 bits (183), Expect = 6.075e-15
Identity = 64/259 (24.71%), Postives = 112/259 (43.24%), Query Frame = 1 
Query: 2236 TATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFE--FKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRN-----IALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            T+ +DWCE NY +   IAEF+NT+SN L    P     +SR +   F     + +  L++VG GS  FH TL +  Q+LDEL ++W          +    ++    R L           +N    K   +++ ++ +  T L   NP L+      L+ + I  TV ++   +R  N     + L++ + +T+ F  W  D +FC   +               +H +WH+     +Y   +   ++ +   SE P+
Sbjct:   23 TSEVDWCEHNYAIVPTIAEFYNTLSNALFFVLPPLCFHLSRPYARHFNRGINLIWALLLVVGAGSAYFHATLSFLGQMLDELAILWV---------IMSALAMWFPRRLLPQ------AFRKNRGRFK---VVMCALTLVVTALAFVNPALNS---VTLMAFGIPCTVLLITELKRCENNRVYKLGLVAGAWWTLAFLCWISDRLFCDLWEAVN---------FPYLHCFWHVLICLAAYLGCVCFAYLHVL--SEAPE 249
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003908.1 (pep scaffold:Pmarinus_7.0:GL477055:153431:171430:1 gene:ENSPMAG00000003581.1 transcript:ENSPMAT00000003908.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.077 bits (144), Expect = 4.603e-11
Identity = 35/86 (40.70%), Postives = 49/86 (56.98%), Query Frame = 1 
Query: 2236 TATIDWCEENYEVSYYIAEFWNTISNFLMIAFP--VCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIW 2487
            ++ IDWCE+NY  S  IAEF+NT+SN      P  + +L+       G      +L +++VG  S  FH TL Y  QLLDEL ++W
Sbjct:    9 SSGIDWCEDNYRHSRNIAEFYNTVSNVAFFLLPPLMHYLFAPYGRQRGPAVHAVWLLMMVVGACSIYFHWTLSYVGQLLDELSILW 94
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Yeast
Match: YDC1 (Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication [Source:SGD;Acc:S000006008])

HSP 1 Score: 117.472 bits (293), Expect = 4.024e-29
Identity = 86/279 (30.82%), Postives = 143/279 (51.25%), Query Frame = 1 
Query: 2218 GYWSPRTATIDWCEENYEVSYYIAEFWNTISN--FLMIAFPVCFLWISRNWNIGFEFK--MCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSI-SLTERFLNYVSQIRFKMERNATNLKTNLLIIYSI-----VVTFTYLCIPNPLLHHSCYALL----VIYTIYRTVQIVKIEQRSRNI---ALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSL-INPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYV 3000
            GYW   T+ IDWCEENY VS YIAE+ NTI+N  FLM AF   +      W    E +  +  +   LVGIGSW FHMTL Y  QLLDELPM++ +        +   +SI + T+  L     I+ + +R  ++ +  ++I + +     ++T+ Y+ +  P +    Y +L    V+ + + T   V      +N+    ++    + IGF  W +D   C +    R +  +L +  L ++HAWWH+ +G G Y ++++L ++ +     NP  ++
Sbjct:   14 GYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTY----SAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYAT--------IIPSWSIFAETQEIL-----IKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHG-NPNDFL 274
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Yeast
Match: YPC1 (Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000387])

HSP 1 Score: 111.694 bits (278), Expect = 2.984e-27
Identity = 78/259 (30.12%), Postives = 127/259 (49.03%), Query Frame = 1 
Query: 2218 GYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKM-ERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYT-------IYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSL-INPLSQMHAWWHIFSGFGSYFYLIFLTHISM 2967
            G W   T+TIDWCEENY VS YIAE+ NT++N + I   +   + +    +   F +      LVG+GSW FHMTL Y  QLLDELPMI+  C+   ++ +C        E  LN  +  +  + E+    +   L +  + ++   Y+   N  +H   + + ++          YR V     ++  +    + A  +  G+  W +D  +C +  + R S  +L +  L + H WWHI +G G YFY++ L H+ +
Sbjct:   15 GVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSL-VCEA-----KEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASIL---YVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRV 264
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Nematostella
Match: EDO47751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLT6])

HSP 1 Score: 63.1586 bits (152), Expect = 9.514e-11
Identity = 65/254 (25.59%), Postives = 106/254 (41.73%), Query Frame = 1 
Query: 2236 TATIDWCEENYEVSYYIAEFWNTISNFLMIAFPVCFLWISRNW--NIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQ 2991
            ++ +DWCE NY  S  IAEF+NTISN + +  P   +++ R +   IG+   +  L ++++G+ S  FH TL    QLLDEL ++W   +L+    L     +     F     ++ + M      + T L  IY     F  + +  P      +A L+   ++R        ++ R + +     +      W  D IFC   +               +H  WHIF    SY   +   +I     SE PQ
Sbjct:    9 SSEVDWCELNYVHSNSIAEFFNTISNAIFLVIPPFLMYLFRPYANRIGYGINVILLLMVVIGLCSAYFHATLSLVGQLLDELAILW---VLMAAFALWAPRWLFQNGPFYGKRCRLAYIMATIGV-MGTILGFIYPAANAFALMLLGIP------WAGLLFTEVFRYP-----SKQVRRLGVFCIIWWFTALACWINDRIFCDMWKQLS---------FPYLHCGWHIFIFIASYIACVLSAYIYAA--SEFPQ 236
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Match: acer3 (alkaline ceramidase 3 [Source:NCBI gene;Acc:101155496])

HSP 1 Score: 187.193 bits (474), Expect = 6.948e-53
Identity = 106/264 (40.15%), Postives = 151/264 (57.20%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPV-CFLWISRNWNIGFEFK-MC-YLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHIS---MKHRSE 2982
            ++G W P T+T+DWCEENYEV+ Y+AEFWNT+SN +MI  P+   L   RN   G EF+ +C +L L  VG+GSW FHMTLLY MQLLDELPMI+ +C+ +  +  C                   FK E+    +   LL ++S+ V+  YL    P+ H   Y +LV   + R++ IV  +    R +   S + + +GF  WNIDNIFC+ L+  R      +  L+Q HAWWHIF+G GSY +++    I    +K R++
Sbjct:    7 RLGLWGPPTSTLDWCEENYEVTVYVAEFWNTVSNLIMILPPLFGALQTFRN---GLEFRYICSFLGLAAVGVGSWCFHMTLLYEMQLLDELPMIYSTCVFVYCLYEC-------------------FKQEKTVGLIPITLLFVFSMSVSLVYLQWKEPVFHQVMYGVLVACLVMRSIFIVTWVYPWLRPLCYASLAIFMLGFLLWNIDNIFCEQLRTSRRVLPPGLGVLTQFHAWWHIFTGLGSYLHILLSLQIRSTFLKRRAK 248
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Match: acer3 (alkaline ceramidase 3 [Source:NCBI gene;Acc:101155496])

HSP 1 Score: 180.644 bits (457), Expect = 7.089e-51
Identity = 102/249 (40.96%), Postives = 144/249 (57.83%), Query Frame = 1 
Query: 2212 KVGYWSPRTATIDWCEENYEVSYYIAEFWNTISNFLMIAFPV-CFLWISRNWNIGFEFK-MC-YLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVK-IEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLI 2946
            ++G W P T+T+DWCEENYEV+ Y+AEFWNT+SN +MI  P+   L   RN   G EF+ +C +L L  VG+GSW FHMTLLY MQLLDELPMI+ +C+ +  +  C                   FK E+    +   LL ++S+ V+  YL    P+ H   Y +LV   + R++ IV  +    R +   S + + +GF  WNIDNIFC+ L+        +   L+Q HAWWHIF+G GSY +++
Sbjct:    7 RLGLWGPPTSTLDWCEENYEVTVYVAEFWNTVSNLIMILPPLFGALQTFRN---GLEFRYICSFLGLAAVGVGSWCFHMTLLYEMQLLDELPMIYSTCVFVYCLYEC-------------------FKQEKTVGLIPITLLFVFSMSVSLVYLQWKEPVFHQVMYGVLVACLVMRSIFIVTWVYPWLRPLCYASLAIFMLGFLLWNIDNIFCEQLRRVLPPGLGV---LTQFHAWWHIFTGLGSYLHIL 230
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Match: ENSORLT00000040305.1 (pep primary_assembly:ASM223467v1:1:25459511:25466649:-1 gene:ENSORLG00000028409.1 transcript:ENSORLT00000040305.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 171.785 bits (434), Expect = 7.015e-43
Identity = 92/266 (34.59%), Postives = 153/266 (57.52%), Query Frame = 2 
Query:  629 NLHPEKQYRS*QVGEKI*QVFAKHEYDLGKTNLLEHEIVLTNSKPITLRPYQ-----KNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPLLY-MYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            NL  E +YR   +      VF+    DLG+TN+++H+I+ T    +  +P +     +   D+QV+  L+  + R+S S++ + ++ V KK  S  LC DYR +N+ T K+ + LP +      +  AKYFS +D   G++Q+++        AF T  G + + +MPFGL  APATFQR M+ +L  + +   +VY +DI+VL  +  + +E  E VF RL  ANLK KPSKC+  + +V Y+G+++S  G+  DP  ++K +++
Sbjct:  788 NLPEESRYRLAGLLRSYSDVFSAGSTDLGRTNVVQHDILTTPGSAVKQQPRRMSREKQEAADQQVQQSLEAGLARHSNSSWAAPIVMVKKKDQSPRLCVDYRPLNDRTIKDAYPLPRIQDTLDTLSTAKYFSTLDLTSGYWQVEMTPRARKAAAFCTRKGLFEWNVMPFGLCNAPATFQRLMDRVLAGLQWEACLVYLDDIIVLGCNSNQMMERLEQVFTRLRQANLKLKPSKCRLFQEQVAYLGHVVSAQGISTDPQKIQKVQDW 1053
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Match: ENSORLT00000041485.1 (pep primary_assembly:ASM223467v1:15:30019002:30023522:-1 gene:ENSORLG00000028547.1 transcript:ENSORLT00000041485.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 160.999 bits (406), Expect = 3.608e-42
Identity = 89/247 (36.03%), Postives = 149/247 (60.32%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPI--TLRPYQKNQVD---KQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLP-LLYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            VF+ H+ D G TN ++H+I L +  P     RP   N ++   K ++ +LK  +IR S+S+F S ++ V K+   V LC DYR +N  T K+ + LP L   +  +  +K+F+V+D + G+YQI++ +     TAF T +G + +  MP G+T AP+TFQR M   + D++    +V+ +DI+V S++LE+H E    V KRL    LK  P KC++ +S V+Y+G+++S+ G++ DP  V   +++
Sbjct:  293 VFSHHDLDFGCTNQIKHQIHLHDPTPFKHRARPIHPNDIEAVRKHIQDLLKAGVIRESESSFSSPIVVVRKRNGDVRLCIDYRKLNLQTIKDAYALPNLEESFSALTGSKWFTVLDLKSGYYQIEMDEKDRAKTAFVTPLGFWEWNRMPQGVTNAPSTFQRLMEKCMGDLNLREVLVFLDDIIVFSATLEEHEERLLKVLKRLKEFGLKLSPDKCRFFQSSVRYLGHVVSERGVETDPEKVSTLKSW 539

HSP 2 Score: 32.3426 bits (72), Expect = 3.608e-42
Identity = 14/38 (36.84%), Postives = 22/38 (57.89%), Query Frame = 3 
Query: 1380 TSKKPRISKNMKHIKGFMGLFGYYRTFIINLSATPLPL 1493
            T K   + +N+K ++ F+G  GYYR FI + +    PL
Sbjct:  535 TLKSWPVPRNLKELRSFLGFAGYYRRFIKSYATIVGPL 572
[Close]
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Match: ENSORLT00000034816.1 (pep primary_assembly:ASM223467v1:11:17160839:17165359:-1 gene:ENSORLG00000030569.1 transcript:ENSORLT00000034816.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 160.999 bits (406), Expect = 3.699e-42
Identity = 89/247 (36.03%), Postives = 149/247 (60.32%), Query Frame = 2 
Query:  686 VFAKHEYDLGKTNLLEHEIVLTNSKPI--TLRPYQKNQVD---KQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLP-LLYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHY--AVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            VF+ H+ D G TN ++H+I L +  P     RP   N ++   K ++ +LK  +IR S+S+F S ++ V K+   V LC DYR +N  T K+ + LP L   +  +  +K+F+V+D + G+YQI++ +     TAF T +G + +  MP G+T AP+TFQR M   + D++    +V+ +DI+V S++LE+H E    V KRL    LK  P KC++ +S V+Y+G+++S+ G++ DP  V   +++
Sbjct:  293 VFSHHDLDFGCTNQIKHQIHLHDPTPFKHRARPIHPNDIEAVRKHIQDLLKAGVIRESESSFSSPIVVVRKRNGDVRLCIDYRKLNLQTIKDAYALPNLEESFSALTGSKWFTVLDLKSGYYQIEMDEKDRAKTAFVTPLGFWEWNRMPQGVTNAPSTFQRLMEKCMGDLNLREVLVFLDDIIVFSATLEEHEERLLKVLKRLKEFGLKLSPDKCRFFQSSVRYLGHVVSERGVETDPEKVSTLKSW 539

HSP 2 Score: 32.3426 bits (72), Expect = 3.699e-42
Identity = 14/38 (36.84%), Postives = 22/38 (57.89%), Query Frame = 3 
Query: 1380 TSKKPRISKNMKHIKGFMGLFGYYRTFIINLSATPLPL 1493
            T K   + +N+K ++ F+G  GYYR FI + +    PL
Sbjct:  535 TLKSWPVPRNLKELRSFLGFAGYYRRFIKSYATIVGPL 572
[Close]
BLAST of Alkaline ceramidase vs. Planmine SMEST
Match: SMESG000043974.1 (SMESG000043974.1)

HSP 1 Score: 498.819 bits (1283), Expect = 2.542e-170
Identity = 244/244 (100.00%), Postives = 244/244 (100.00%), Query Frame = 1 
Query: 2320 MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 3051
            MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK
Sbjct:    1 MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 244
[Close]
BLAST of Alkaline ceramidase vs. Planmine SMEST
Match: SMESG000043974.1 (SMESG000043974.1)

HSP 1 Score: 442.58 bits (1137), Expect = 6.226e-149
Identity = 222/244 (90.98%), Postives = 222/244 (90.98%), Query Frame = 1 
Query: 2320 MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 3051
            MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTV                      FKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK
Sbjct:    1 MIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTV----------------------FKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 222
[Close]
BLAST of Alkaline ceramidase vs. Planmine SMEST
Match: SMESG000043974.1 (SMESG000043974.1)

HSP 1 Score: 396.741 bits (1018), Expect = 1.184e-131
Identity = 200/222 (90.09%), Postives = 200/222 (90.09%), Query Frame = 1 
Query: 2386 MCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVSQIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 3051
            MCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTV                      FKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK
Sbjct:    1 MCYLSLILVGIGSWAFHMTLLYPMQLLDELPMIWCSCLLLNTV----------------------FKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 200
[Close]
BLAST of Alkaline ceramidase vs. Planmine SMEST
Match: SMESG000043974.1 (SMESG000043974.1)

HSP 1 Score: 317.005 bits (811), Expect = 6.153e-102
Identity = 155/155 (100.00%), Postives = 155/155 (100.00%), Query Frame = 1 
Query: 2587 MERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 3051
            MERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK
Sbjct:    1 MERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTIYRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFSLINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPIVRPTSSTNNK 155
[Close]
BLAST of Alkaline ceramidase vs. Planmine SMEST
Match: SMESG000080881.1 (SMESG000080881.1)

HSP 1 Score: 248.054 bits (632), Expect = 1.981e-71
Identity = 160/447 (35.79%), Postives = 259/447 (57.94%), Query Frame = 2 
Query:   89 LSCQIKLCDQELHHYILVMRTLAAEYLLGKYPKEAQKG-GLDCATGTLV*LVGKKRKINNDDR-VFVNLTMTIPARFETVCFVALSKQSEEEVLLEPDEGFSLKYDLSITYSVAKVENGRIPIRDSQLKN*TIKTIPRDQN*KSIKTRRIRTNRKWR-IGIVSHNR*IVVR**AL*CFHSK*QNLHPEKQYRS*QVGEKI*QVFAKHEYDLGKTNLLEHEIVLTNSKPITLRPYQ-----KNQVDKQVKFMLKHEIIRYSKSTFQSLMIEVAKK*VSV*LCKDYRTVNNDTFKENHQLPL-LYMYGKIRNAKYFSVMDSQKGFYQIKLKDDTIPITAF*TSMGHY*YYIMPFGLT*APATFQRAMNLMLMDVHYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSKCKWTESKVKYVGYIISKDGMKPDPANVEKTENF 1402
            L  ++ + D EL H++ VMR      L+G    E  +G  LD  TG L  + G+  +  +  R VF+N T+ +PAR E + +  +   S++E + EP+E    KY++ +   V KV++  +P+R        I+  P+ +  K  K    +T +  R I I    + I               +L   +++   ++ +K   VFAKHEYDLG T ++EHEI L +  PI L+PY+     + + D+Q+K M + +IIR S S F S +  V KK   +  C DYR +N  T K+ + +P+   M+ ++   ++F+V+D  KG+ Q K+K++    TAF    G Y + ++PFGLT APATFQR MN +L D+ +A+VY +DI++ S++ ++HL+  E VF+RL+ ANLK KPSKC+W +S+V YVG+IIS++G++P+P NV+K + +
Sbjct: 3171 LKAELIIGDHELVHHVSVMRNSPVGCLIGMDVMEQLQGISLDLKTGRL--MKGQTDEKRHKVREVFLNQTLELPARSEVIYYADVLDVSDDECIFEPNEKLIEKYEIPMCDEVVKVKDQTVPVRIVNQNTKPIQMKPKTKLGKLTKFEIEKTPKLPRNIKIYKQPQVIS-------------NDLTESQKWEFTELLKKYKMVFAKHEYDLGLTQVIEHEIPLLDETPIKLKPYRIPYIHQEESDRQIKAMKEFKIIRDSSSPFSSSIAVVKKKDGDLRFCVDYRKLNQVTRKDTYPIPVPQEMFDQMGEVQFFTVIDLNKGYNQFKVKEEDRRKTAFSDGKGLYEFNVLPFGLTGAPATFQRGMNFVLRDIPHALVYIDDIIIFSNTFKEHLKDVETVFRRLLKANLKIKPSKCEWGKSEVVYVGHIISRNGLQPNPENVKKIKEY 3602

HSP 2 Score: 42.743 bits (99), Expect = 1.981e-71
Identity = 30/78 (38.46%), Postives = 44/78 (56.41%), Query Frame = 3 
Query: 1398 ISKNMKHIKGFMGLFGYYRTFIINLSATPLPLT**EDKNVKFV*GHE*NEAFDXXXXXXXERPILLYPDFEKQFMVIT 1631
            I +N+  ++ F+GL  YYR FI + S    PL     K  +F  G    EAF  LKK L+++PIL  P+F   F+++T
Sbjct: 3604 IPENVDQVRQFLGLASYYRKFIKSFSHVAQPLNVLLKKQTQFKWGKSQQEAFKLLKKSLIKKPILRCPNFRIPFILMT 3681
The following BLAST results are available for this feature:
BLAST of Alkaline ceramidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ACER31.840e-5437.87alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC... [more]
ACER38.541e-4433.82alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC... [more]
ACER32.988e-3538.50alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC... [more]
ACER36.331e-2232.89alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC... [more]
ACER21.067e-1426.64alkaline ceramidase 2 [Source:HGNC Symbol;Acc:HGNC... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
W02F12.24.806e-825.49Alkaline ceramidase [Source:UniProtKB/Swiss-Prot;... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
bwa4.443e-1628.46gene:FBgn0045064 transcript:FBtr0081331[more]
bwa8.858e-1628.46gene:FBgn0045064 transcript:FBtr0331184[more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
acer31.395e-5339.46alkaline ceramidase 3 [Source:ZFIN;Acc:ZDB-GENE-09... [more]
BX511082.11.173e-3432.14pep chromosome:GRCz11:9:14291932:14297132:1 gene:E... [more]
BX890543.12.006e-3431.25pep chromosome:GRCz11:14:42224893:42231293:-1 gene... [more]
BX511224.15.357e-3432.14pep chromosome:GRCz11:2:18017000:18022765:1 gene:E... [more]
CR855320.11.701e-3331.44pep chromosome:GRCz11:1:7956030:7961696:1 gene:ENS... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tspyl21.231e-4739.18TSPY-like 2 [Source:Xenbase;Acc:XB-GENE-1016996][more]
anxa62.824e-4134.75annexin A6 [Source:Xenbase;Acc:XB-GENE-989741][more]
tspyl21.683e-3634.08TSPY-like 2 [Source:Xenbase;Acc:XB-GENE-1016996][more]
ENSXETT00000006041.11.652e-3432.13pep primary_assembly:Xenopus_tropicalis_v9.1:6:373... [more]
alkbh59.550e-3128.68alkB homolog 5, RNA demethylase [Source:Xenbase;Ac... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Acer33.003e-5137.50alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Acer32.280e-3335.21alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Acer37.989e-3239.55alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Acer32.313e-2148.81alkaline ceramidase 3 [Source:MGI Symbol;Acc:MGI:1... [more]
Acer27.393e-1527.41alkaline ceramidase 2 [Source:MGI Symbol;Acc:MGI:1... [more]
back to top
BLAST of Alkaline ceramidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9NUN7|ACER3_HUMAN8.838e-5437.87Alkaline ceramidase 3 OS=Homo sapiens OX=9606 GN=A... [more]
sp|Q9D099|ACER3_MOUSE2.100e-5037.50Alkaline ceramidase 3 OS=Mus musculus OX=10090 GN=... [more]
sp|P20825|POL2_DROME9.737e-4236.80Retrovirus-related Pol polyprotein from transposon... [more]
sp|P04323|POL3_DROME4.667e-3437.38Retrovirus-related Pol polyprotein from transposon... [more]
sp|Q7LHG5|YI31B_YEAST5.897e-2834.65Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomy... [more]
back to top
BLAST of Alkaline ceramidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A355ABF24.167e-5932.90Uncharacterized protein OS=Flavobacteriaceae bacte... [more]
A0A1W3JTM79.337e-5641.24Alkaline ceramidase OS=Ciona intestinalis OX=7719 ... [more]
A0A1S3HRJ73.991e-5437.36Alkaline ceramidase OS=Lingula unguis OX=7574 GN=L... [more]
A0A5E4N8W89.062e-5439.31Alkaline ceramidase OS=Cinara cedri OX=506608 GN=C... [more]
A0A2C9KPP42.147e-5340.93Alkaline ceramidase OS=Biomphalaria glabrata OX=65... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
acer32.087e-4539.92alkaline ceramidase 3 [Source:ZFIN;Acc:ZDB-GENE-09... [more]
ENSAMXT00000048130.11.605e-4336.29pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000041754.12.818e-4338.43pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000052892.13.737e-4335.34pep primary_assembly:Astyanax_mexicanus-2.0:15:168... [more]
ENSAMXT00000037150.11.615e-4236.95pep primary_assembly:Astyanax_mexicanus-2.0:10:222... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
acer26.075e-1524.71alkaline ceramidase 2 [Source:ZFIN;Acc:ZDB-GENE-12... [more]
ENSPMAT00000003908.14.603e-1140.70pep scaffold:Pmarinus_7.0:GL477055:153431:171430:1... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
YDC14.024e-2930.82Alkaline dihydroceramidase, involved in sphingolip... [more]
YPC12.984e-2730.12Alkaline ceramidase; also has reverse (CoA-indepen... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO477519.514e-1125.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Alkaline ceramidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
acer36.948e-5340.15alkaline ceramidase 3 [Source:NCBI gene;Acc:101155... [more]
acer37.089e-5140.96alkaline ceramidase 3 [Source:NCBI gene;Acc:101155... [more]
ENSORLT00000040305.17.015e-4334.59pep primary_assembly:ASM223467v1:1:25459511:254666... [more]
ENSORLT00000041485.13.608e-4236.03pep primary_assembly:ASM223467v1:15:30019002:30023... [more]
ENSORLT00000034816.13.699e-4236.03pep primary_assembly:ASM223467v1:11:17160839:17165... [more]
back to top
BLAST of Alkaline ceramidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000043974.12.542e-170100.00SMESG000043974.1[more]
SMESG000043974.16.226e-14990.98SMESG000043974.1[more]
SMESG000043974.11.184e-13190.09SMESG000043974.1[more]
SMESG000043974.16.153e-102100.00SMESG000043974.1[more]
SMESG000080881.11.981e-7135.79SMESG000080881.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30005178 ID=SMED30005178|Name=Alkaline ceramidase|organism=Schmidtea mediterranea sexual|type=transcript|length=3143bp
TATTAAACCAAAAAGAATTGGAATCCATGCCGGTAGCTGGTATTCACCTG
ACTGTTGTAACTGGAGCACAATTAAAAATTATTGGAACTTATCATGCCAA
ATAAAGCTGTGTGACCAGGAGCTACATCATTATATATTGGTAATGAGAAC
GTTAGCTGCAGAATATCTTCTAGGAAAATATCCTAAAGAAGCTCAAAAGG
GTGGTCTTGATTGTGCCACAGGAACACTAGTTTGATTAGTGGGTAAAAAA
AGGAAAATTAATAATGATGACAGAGTGTTCGTCAATCTTACAATGACTAT
CCCTGCCAGATTCGAGACAGTATGTTTCGTAGCATTGAGTAAACAGTCGG
AAGAAGAGGTTTTGTTAGAACCTGATGAAGGATTTTCATTAAAATATGAT
TTATCTATCACTTATAGTGTCGCCAAAGTAGAAAACGGAAGAATACCCAT
ACGGGATAGTCAACTTAAAAATTAAACCATTAAAACTATACCGAGAGATC
AGAATTGAAAGAGTATCAAAACCAGGAGAATCAGGACTAACCGGAAATGG
AGAATCGGTATTGTTAGTCATAATAGATGAATTGTAGTCAGATAATGAGC
ATTATGATGCTTCCACAGCAAATAGCAAAACCTTCACCCTGAGAAACAAT
ATAGAAGTTAACAGGTTGGTGAGAAAATATGACAGGTATTCGCAAAACAC
GAATACGACTTGGGTAAAACAAATTTGCTGGAACACGAGATCGTGCTCAC
AAATTCAAAGCCAATCACACTAAGACCTTATCAAAAAAATCAAGTAGACA
AACAAGTCAAATTTATGCTTAAACACGAGATAATAAGGTACAGTAAGTCA
ACTTTTCAATCACTTATGATAGAAGTTGCAAAGAAATAAGTATCAGTATG
ACTATGTAAAGATTACCGTACAGTTAACAATGATACGTTCAAAGAGAATC
ATCAATTACCATTACTCTATATGTATGGAAAAATACGAAATGCAAAATAC
TTCTCAGTTATGGACTCTCAAAAGGGATTTTATCAGATCAAATTGAAAGA
CGACACAATACCAATTACGGCATTTTAAACGAGTATGGGACATTACTAAT
ATTATATCATGCCTTTTGGTCTCACATGAGCACCAGCAACGTTCCAAAGA
GCCATGAACCTAATGCTAATGGACGTACATTATGCAGTGGTATATTTCAA
TGACATCGTTGTCTTATCATCGAGTTTAGAGAAACATTTAGAACACAAAG
AAGATGTGTTTAAGCGACTAATCAATGCCAATCTAAAGTTCAAGCCTAGC
AAATGTAAATGGACCGAATCAAAGGTTAAGTATGTTGGGTACATTATCTC
AAAAGACGGAATGAAACCAGATCCAGCGAACGTCGAAAAAACCGAGAATT
TCCAAAAACATGAAGCATATAAAAGGTTTCATGGGCCTATTTGGTTATTA
CAGAACGTTTATCATAAACCTTTCTGCAACACCATTACCACTTACATAAT
AAGAAGACAAAAACGTCAAATTTGTCTAGGGTCACGAGTAGAACGAAGCA
TTTGACAAGCTAAAGAAACTACTTTTGGAACGTCCAATTCTGCTATACCC
TGATTTTGAGAAACAATTCATGGTCATAACAAAGTAAAAGTTATTTACAG
AACCATCGAAAAACAAATCTTCAACGAAGCCTGAAAAGGGAGATTCTACT
TGTAATAAGTACATTGTACCAGCATACCTAATCTGCTCAAGTTTGGATGC
GCTCCAAAACAGCAAATGTGTATTGTCATGACCTCCAGCCGTCAGAATAC
CCGATTGAGGAGTCTCTTTTCCGAGTTAAGTCGATCGACGGTCATAATAC
ATCTTTAGATCCATTCTATCAATAAACCATTTGTCATATAAATCCCAGGG
GCAACTGACCCAATCCTTTTGCAGCCCGAATCAACTTTGGAAATAGTCAA
TGGCGATCTCGGGCAAAAAATATTACGGTTCAGTGTGAAATACGAGAAAC
CAGTGAGGTTGTTGAGATATTAGAATTTGTTAGTGTTTCACGATTAAAGT
GGGTGAATGATAATAAGTGGACTTATGAACTAAATGAAAATTACTAACGG
TCATTCAAGTTCTTCGTCAGAATGAAAATAACCTCAAAGAAAGAAGATGA
ATTAATCATTTTCGTAGCCACTCATCTCGTCATATCTGTTTTCCTATCAG
GTCTTCTAATGAAGGTTGGATATTGGAGTCCTAGAACAGCTACTATTGAC
TGGTGTGAAGAGAATTATGAAGTTTCATACTACATTGCAGAGTTTTGGAA
TACAATCAGTAATTTTCTAATGATTGCATTTCCCGTTTGTTTTCTATGGA
TTTCACGGAATTGGAATATTGGATTCGAATTCAAGATGTGTTATTTAAGC
CTTATTTTAGTTGGTATTGGATCTTGGGCATTTCACATGACTCTCCTATA
TCCTATGCAACTTTTGGATGAGTTACCAATGATATGGTGTTCATGTTTGT
TATTGAATACCGTAGAGCTATGTCGGCAATTCTCTATCAGTCTGACAGAA
CGTTTCCTGAATTACGTCAGTCAAATTCGTTTCAAAATGGAACGGAACGC
AACAAATTTGAAGACGAACTTGTTAATAATTTATTCAATTGTTGTTACTT
TTACTTACCTCTGTATTCCAAATCCTCTTCTCCATCATTCCTGTTATGCT
CTATTAGTGATATATACAATTTATCGAACGGTGCAGATTGTTAAAATAGA
ACAACGCTCAAGAAATATTGCACTAATTTCAGCATCAACTTATACAATCG
GATTTTTCTTTTGGAATATTGACAATATTTTCTGTAAATATTTACAAAAC
TTCCGGTCTTCCGAATTTTCACTCATTAATCCATTGTCTCAAATGCACGC
ATGGTGGCATATTTTCAGTGGTTTTGGCAGTTATTTTTACTTGATATTTT
TAACGCATATTTCAATGAAACACCGGAGTGAAAATCCTCAATCTTATGTC
ATTGGATATATTGTTCCTATTGTTCGACCAACTTCATCTACAAATAATAA
AAGTAGAAGAGTTTTGTAGTGATTTTTCATTATTTGTTTTTAGTTTAGTT
GGCTTTCATTAGTTTTTTTTTAATAAAAATTGATAAGCCTGGC
back to top

protein sequence of SMED30005178-orf-1

>SMED30005178-orf-1 ID=SMED30005178-orf-1|Name=SMED30005178-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=134bp
MNLMLMDVHYAVVYFNDIVVLSSSLEKHLEHKEDVFKRLINANLKFKPSK
CKWTESKVKYVGYIISKDGMKPDPANVEKTENFQKHEAYKRFHGPIWLLQ
NVYHKPFCNTITTYIIRRQKRQICLGSRVERSI*
back to top

protein sequence of SMED30005178-orf-2

>SMED30005178-orf-2 ID=SMED30005178-orf-2|Name=SMED30005178-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=316bp
MKITSKKEDELIIFVATHLVISVFLSGLLMKVGYWSPRTATIDWCEENYE
VSYYIAEFWNTISNFLMIAFPVCFLWISRNWNIGFEFKMCYLSLILVGIG
SWAFHMTLLYPMQLLDELPMIWCSCLLLNTVELCRQFSISLTERFLNYVS
QIRFKMERNATNLKTNLLIIYSIVVTFTYLCIPNPLLHHSCYALLVIYTI
YRTVQIVKIEQRSRNIALISASTYTIGFFFWNIDNIFCKYLQNFRSSEFS
LINPLSQMHAWWHIFSGFGSYFYLIFLTHISMKHRSENPQSYVIGYIVPI
VRPTSSTNNKSRRVL*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006629lipid metabolic process
GO:0006672ceramide metabolic process
GO:0008284positive regulation of cell proliferation
GO:0030148sphingolipid biosynthetic process
GO:0046512sphingosine biosynthetic process
GO:0071602phytosphingosine biosynthetic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000018Category 4 cell
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000418head
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR008901ACER
IPR000477RT_dom
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0000139Golgi membrane
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0005794Golgi apparatus
GO:0016020membrane
GO:0030173integral component of Golgi membrane
GO:0030176integral component of endoplasmic reticulum membrane
Vocabulary: molecular function
TermDefinition
GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0016787hydrolase activity
GO:0070774phytoceramidase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR008901Alkaline ceramidasePFAMPF05875Ceramidasecoord: 33..296
e-value: 2.0E-66
score: 224.1
IPR008901Alkaline ceramidasePANTHERPTHR46187FAMILY NOT NAMEDcoord: 32..307
NoneNo IPR availablePANTHERPTHR46187:SF3ALKALINE CERAMIDASE 3coord: 32..307
NoneNo IPR availableTMHMMTMhelixcoord: 258..280
NoneNo IPR availableTMHMMTMhelixcoord: 55..77
NoneNo IPR availableTMHMMTMhelixcoord: 216..238
NoneNo IPR availableTMHMMTMhelixcoord: 13..35
NoneNo IPR availableTMHMMTMhelixcoord: 90..112
NoneNo IPR availableTMHMMTMhelixcoord: 173..195