Transient receptor potential cation channel subfamily M member 8
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004958 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Match: TRPM2 (transient receptor potential cation channel subfamily M member 2 [Source:HGNC Symbol;Acc:HGNC:12339]) HSP 1 Score: 173.326 bits (438), Expect = 2.133e-42 Identity = 157/671 (23.40%), Postives = 301/671 (44.86%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKH-----KENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQ---------------ISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNA---QNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E G+ L D H +F+ DDGT QY E+ R + E ++ +T +V ++ EGG + + + P V+V+GSG +A++IA V LP S ++ +S E F +S+ I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F D K S + L N+PEF++LF+EN ++++F+ + L LY+ + +P++ CA L ++ + +V+++L G+ + LY + + + ++ +L+L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + +E +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++ L + +F PL++ S+ KR++ A F +V F++ +LSY +FL +F Y+ +V+ +P+ E IY+++F+ +CEE+RQ E + + L FS
Sbjct: 265 ILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESR--IVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFMDEWQWKPS--DLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRL--------------------QMHHVAQVLRELLGDFTQPLYPRPRHN-DRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAE---EYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM-LAF----PLLLTGL----------------------------ISFREKRLQDVGTPAARARAFFTAPVVV-FHLNILSYFAFLCLFAYVLMVDFQPVPS-------WCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFS 865
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Match: TRPM2 (transient receptor potential cation channel subfamily M member 2 [Source:HGNC Symbol;Acc:HGNC:12339]) HSP 1 Score: 173.326 bits (438), Expect = 2.148e-42 Identity = 157/671 (23.40%), Postives = 301/671 (44.86%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKH-----KENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQ---------------ISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNA---QNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E G+ L D H +F+ DDGT QY E+ R + E ++ +T +V ++ EGG + + + P V+V+GSG +A++IA V LP S ++ +S E F +S+ I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F D K S + L N+PEF++LF+EN ++++F+ + L LY+ + +P++ CA L ++ + +V+++L G+ + LY + + + ++ +L+L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + +E +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++ L + +F PL++ S+ KR++ A F +V F++ +LSY +FL +F Y+ +V+ +P+ E IY+++F+ +CEE+RQ E + + L FS
Sbjct: 265 ILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESR--IVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFMDEWQWKPS--DLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRL--------------------QMHHVAQVLRELLGDFTQPLYPRPRHN-DRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAE---EYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM-LAF----PLLLTGL----------------------------ISFREKRLQDVGTPAARARAFFTAPVVV-FHLNILSYFAFLCLFAYVLMVDFQPVPS-------WCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFS 865
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Match: TRPM2 (transient receptor potential cation channel subfamily M member 2 [Source:HGNC Symbol;Acc:HGNC:12339]) HSP 1 Score: 173.326 bits (438), Expect = 2.148e-42 Identity = 157/671 (23.40%), Postives = 301/671 (44.86%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKH-----KENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQ---------------ISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNA---QNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E G+ L D H +F+ DDGT QY E+ R + E ++ +T +V ++ EGG + + + P V+V+GSG +A++IA V LP S ++ +S E F +S+ I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F D K S + L N+PEF++LF+EN ++++F+ + L LY+ + +P++ CA L ++ + +V+++L G+ + LY + + + ++ +L+L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + +E +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++ L + +F PL++ S+ KR++ A F +V F++ +LSY +FL +F Y+ +V+ +P+ E IY+++F+ +CEE+RQ E + + L FS
Sbjct: 265 ILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESR--IVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFMDEWQWKPS--DLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRL--------------------QMHHVAQVLRELLGDFTQPLYPRPRHN-DRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAE---EYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM-LAF----PLLLTGL----------------------------ISFREKRLQDVGTPAARARAFFTAPVVV-FHLNILSYFAFLCLFAYVLMVDFQPVPS-------WCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFS 865
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Match: TRPM2 (transient receptor potential cation channel subfamily M member 2 [Source:HGNC Symbol;Acc:HGNC:12339]) HSP 1 Score: 172.17 bits (435), Expect = 4.415e-42 Identity = 156/656 (23.78%), Postives = 300/656 (45.73%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKH-----KENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNA---QNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E G+ L D H +F+ DDGT QY E+ R + E ++ +T +V ++ EGG + + + P V+V+GSG +A++IA V LP S ++ +S E F +S+ I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F D K S + L N+PEF++LF+EN ++++F+ + L LY+ + +P + F K + ++ + +V+++L G+ + LY + + + ++ +L+L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + +E +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++ L + +F PL++ S+ KR++ A F +V F++ +LSY +FL +F Y+ +V+ +P+ E IY+++F+ +CEE+RQ E + + L FS
Sbjct: 265 ILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESR--IVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFMDEWQWKPS--DLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYE-NLDP-----------------SCLFHSKLQ-------MHHVAQVLRELLGDFTQPLYPRPRHN-DRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAE---EYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM-LAF----PLLLTGL----------------------------ISFREKRLQDVGTPAARARAFFTAPVVV-FHLNILSYFAFLCLFAYVLMVDFQPVPS-------WCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFS 845
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Match: TRPM6 (transient receptor potential cation channel subfamily M member 6 [Source:HGNC Symbol;Acc:HGNC:17995]) HSP 1 Score: 159.073 bits (401), Expect = 5.581e-38 Identity = 167/684 (24.42%), Postives = 309/684 (45.18%), Query Frame = 2
Query: 1508 TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME------LPNSKHKENISALVN--------ENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSART-TYFTKKNENEIDLDIL--YIIGKV-----VQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNND--ETSFNEDFYEENGLLSLNAQ---------------------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-----SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMD-------SSEMKLLEKTEEVQYSYPVKRIESEK---------------ISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
TL+ +H +F+ DDGT +Y E++ R E YL +++ +V ++ EGG + V+ + D+ P+V+ +G+G A+L+A + + + KE I ++ +++HLF+ I C ++R I I+D + + D IL A++ G N S + L L + + IA + + ++ K +E+ + L +R +F++L IE + +F+ L +LY N Q LL L + + T + ID+ ++ Y+IG+ +K + NLY KYK + AE L++ T+ F E++ +L + + +L +WA+L +M++ FW+ ++ A++A + R+MA S M+ ++ ++ SK++ L++ +L +A+K+N+ LL EL+ W+N+TCL++A + + F++H+ + +T +WMG L ++W KII++ I + P I+ F K M D S + K Y ++R EK + + + FY A IVKF+ Y ++Y++FL++F Y LVE++P V+ E + IY+FT E +R+
Sbjct: 235 TLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQ---------ILMECMVHRDC---ITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPD--ALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELY----NTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMV----DDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIIS-----IILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQ-------EWLVSIYIFTNAIEVVRE 884
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Match: gtl-1 (GTL-1; Gon-Two Like (TRP subfamily) [Source:UniProtKB/TrEMBL;Acc:G5ECM4]) HSP 1 Score: 112.079 bits (279), Expect = 3.704e-24 Identity = 125/521 (23.99%), Postives = 228/521 (43.76%), Query Frame = 2
Query: 1523 HDNFLFCDDGTEKQYDREVEFRLKFENYL----KNKTDAFLVQILFEGGR--MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMEL--PNSKHKENI-SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTE---------------------KNKLI----------LNDAEIQLNND----------------ETSFNEDF--YEENGLLSLNAQ----NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGEL 2893
H FLF D+GT +Y E+ R + E YL K ++ LV ++ EGG + M H Y IP+++ GSG A+++A + N +NI + LVN + +F + I + E K + I+ + ++ + D I+ ++ G N S + L+L + + IA +F++ + + + + I L +R +F+ L +EN ++KF+ L LY P LL + + + K L +G++V+ L GN+ K+ Y K +F + +N +I ++ +I L N+ E+ +DF EE + + +L +WA+L+ +M+ + W ++ + AL+AS + S+A + L G+ + + F+E S ++ +L+V +L K + +T LL EL W + TCL +A N+ +FL H C+ ++ +W G L
Sbjct: 345 HSYFLFSDNGTVNRYGAEIIMRKRLEAYLAQGDKKRSAIPLVCVVLEGGAFTIKMVHDYVTTIPRIPVIVCDGSGRAADILAFAHQAVSQNGFLSDNIRNQLVNIVRRIFGYDPKTAQKLIKQIVECSTN-KSLMTIFRLGESSREDLDHVIMSCLLKGQNLSPPEQLQLALAWNRADIARTEIFANGT--EWTTQDLHNAMIEALSNDRIDFVHLLLENGVSMQKFLTYGRLEHLYNTDKGPQNTLRTNLLVD------SKHHIK----------LVEVGRLVENLMGNLYKSNYTKEEFKNQYFLFNNRKQFGKRVHSNSNGGRNDVIGPSGDAGRERMSSMQISLINNARNSIISLFNGGGRKRESDDEDDFSNLEEEANMDFTFRYPYSDLMIWAVLTKRQKMAKLMWTHGEEGMAKALVASRLYVSLAKTASLATGEIGMSQDFTEFSDEFSELAVEVLEYCTKHGRDQTLRLLTCELANWGDETCLSLAANNGHRKFLAHPCCQMLLSDLWQGGL 846
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Match: gtl-2 (Gon-Two Like (TRP subfamily) [Source:UniProtKB/TrEMBL;Acc:Q20766]) HSP 1 Score: 111.309 bits (277), Expect = 5.719e-24 Identity = 153/680 (22.50%), Postives = 281/680 (41.32%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLK----NKTDAFLVQILFEGGRMAME--HVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMN-------NNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVI---------KNLYEKYK------FSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELS-PILSNWKII--LTIPFSFIFIK----------------PLIIPTFPPKKIMHEESDKMDSSEMKLLEKT---EEVQYSYPVKRIESEK---------------------ISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
L+ H FL D+GT ++ ++ R EN++ N +V L EGG ++ H Y + +IP ++ GSG A++I+ NS +A V E + +F ++ E E++RK ++ D++ D IL ++ N D+ L L + + +A +FS+ + K S +EK + L +R +F+E +EN ++ F++ L +LY + + TY T + +IG+VV+KL GN K Y++YK + K K++ + + ++D+ + NE EE+ + +L +WA+L+ M+ W +D + LLA + ++ A + D K+ + + K ++ ++ +L + Y+ + +T LL EL W N CL +A ++ FL H C+ + ++W G L SN +++ L P + +F+ P +P +P + I S++ S+ +K E+ Y+ V I S K ++ E R FY + I KF+ + ++++ FL + L+E S+K E +IY T E IR+ +
Sbjct: 305 LNDRHSYFLLADNGTVGRFGADLHLRQNLENHIATFGCNGRKVPVVCTLLEGGISSINAIHDYVTMKPDIPAIVCDGSGRAADIISFAARYINSD--GTFAAEVGEKLRNLIKMVFPETDQE---------EMFRKITECVIRDDLLRIFRYGQEEEEDVDFVILSTVLQKQNLPPDEQLALTLSWNRVDLAKSCLFSNGR--KWSSDVLEKAMNDALYWDRVDFVECLLENGVSMKNFLSINRLENLYNMDDINSAHSVRNWMENFDSMDPHTYLT-----------IPMIGQVVEKLMGNAFQLYYTSRSFKGKYDRYKRINQSSYFHRKRKIVQKELFKKKSDDQINDNE---EEDFSFAYPFNDLLIWAVLTSRHGMAECMWVHGEDAMAKCLLAIRLYKATAKIAEDEYLDVEEAKRLFDNAVKCREDAIELLDQCYRADHDRTLRLLRMELPHWGNNNCLSLAVLANTKTFLAHPCCQILLAELWHGSLKVRSGSNVRVLTALICPPAILFMAYKPKHSKTARLLSEETPEQLP-YPRESITSTTSNRYRYSKGPEEQKETLLEKGSYTKKVTIISSRKNSGVASVYGSASSMMFKREPQLNKFERFRAFYSSPITKFWSWCIAFLIFLTTQTCILLLE-------TSLKPSKYEWITFIYTVTLSVEHIRKLM 949
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Match: gon-2 (Transient receptor potential channel [Source:UniProtKB/Swiss-Prot;Acc:Q93971]) HSP 1 Score: 72.0182 bits (175), Expect = 6.514e-12 Identity = 45/149 (30.20%), Postives = 78/149 (52.35%), Query Frame = 2
Query: 2516 LFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQD----LSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELS-PILSNWKIILTI---PF 2938
L +WA+L+ +M++ W+ ++ + AL+A + +S+A+ + ++ LE + E KKY + LS+ +L Y + +T LL EL W+N TCL +A + FL H C+ + +W G L SN K++L + PF
Sbjct: 550 LMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLAT---EAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPF 695 HSP 2 Score: 51.6026 bits (122), Expect = 8.010e-6 Identity = 35/104 (33.65%), Postives = 51/104 (49.04%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF-------LVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIA 1750
YY S + KG+ T L+ H FL D+GT +Y EV R + E Y+ K F +V ++ EGG + V Y +P+V+ GSG A+L+A
Sbjct: 105 YYPS---SSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLA 205
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Match: gon-2 (Transient receptor potential channel [Source:UniProtKB/Swiss-Prot;Acc:Q93971]) HSP 1 Score: 71.633 bits (174), Expect = 8.263e-12 Identity = 45/149 (30.20%), Postives = 78/149 (52.35%), Query Frame = 2
Query: 2516 LFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQD----LSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELS-PILSNWKIILTI---PF 2938
L +WA+L+ +M++ W+ ++ + AL+A + +S+A+ + ++ LE + E KKY + LS+ +L Y + +T LL EL W+N TCL +A + FL H C+ + +W G L SN K++L + PF
Sbjct: 956 LMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLAT---EAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPF 1101 HSP 2 Score: 51.6026 bits (122), Expect = 9.830e-6 Identity = 35/104 (33.65%), Postives = 51/104 (49.04%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF-------LVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIA 1750
YY S + KG+ T L+ H FL D+GT +Y EV R + E Y+ K F +V ++ EGG + V Y +P+V+ GSG A+L+A
Sbjct: 511 YYPS---SSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLA 611
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Match: gon-2 (Transient receptor potential channel [Source:UniProtKB/Swiss-Prot;Acc:Q93971]) HSP 1 Score: 71.2478 bits (173), Expect = 1.019e-11 Identity = 45/149 (30.20%), Postives = 78/149 (52.35%), Query Frame = 2
Query: 2516 LFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQD----LSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELS-PILSNWKIILTI---PF 2938
L +WA+L+ +M++ W+ ++ + AL+A + +S+A+ + ++ LE + E KKY + LS+ +L Y + +T LL EL W+N TCL +A + FL H C+ + +W G L SN K++L + PF
Sbjct: 855 LMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLAT---EAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPF 1000 HSP 2 Score: 51.6026 bits (122), Expect = 9.610e-6 Identity = 35/104 (33.65%), Postives = 51/104 (49.04%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF-------LVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIA 1750
YY S + KG+ T L+ H FL D+GT +Y EV R + E Y+ K F +V ++ EGG + V Y +P+V+ GSG A+L+A
Sbjct: 410 YYPS---SSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLA 510
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Match: Trpm (gene:FBgn0265194 transcript:FBtr0339082) HSP 1 Score: 119.783 bits (299), Expect = 2.059e-26 Identity = 148/670 (22.09%), Postives = 287/670 (42.84%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI-----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMM----NNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNE--------------DFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGEL-SPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEK-------TEEVQYSYPVKRIESEKISYRE--------------AMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
L+ H FL D+GT+ +Y E+ R K E ++ N + +V ++ EGG + V Y + +P+V+ GSG A+L+A V + + ++ + L+ Q FE + + L + R K I ++ + + D+ IL A+ + S + L L + + IA +F Q+ +++ + L+ +R +F++L +EN ++KF+ L +LY P A L + R R + K + L+ IG V+ KL G ++ Y + KF K++ + A + + F E L L +WA+L+ +M+L+ W ++ + +L++ + ++MA + D + ++ +K+++ +L +Y+++ K LL EL W+N +CL +A ++ L H + + +WMG L + +N+K+IL + F +I+ L + EE +M +E + LE ++ Q V +S+ +RE +R+ FY A I KF+ ++Y+ FL++F + LV+++ + + E Y Y+ T E++R+ + ++EP
Sbjct: 222 LNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRN-KNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYG--QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-----ANTLGYILRDVRP-HIPKGY-----IYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF-YIRQLDFKS-------KEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ-------EWYSIAYITTLGFEKVREII--SSEP 860
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Match: Trpm (gene:FBgn0265194 transcript:FBtr0339075) HSP 1 Score: 117.857 bits (294), Expect = 6.120e-26 Identity = 149/682 (21.85%), Postives = 288/682 (42.23%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI-----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMM----NNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNE--------------DFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTIPFSFIFIKPLIIPT------FPPKKIMH--------EESDKMDSSEMKLLEKT-----EEVQYSYPVKRIESEKISYRE--------------AMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
L+ H FL D+GT+ +Y E+ R K E ++ N + +V ++ EGG + V Y + +P+V+ GSG A+L+A V + + ++ + L+ Q FE + + L + R K I ++ + + D+ IL A+ + S + L L + + IA +F Q+ +++ + L+ +R +F++L +EN ++KF+ L +LY P A L + R R + K + L+ IG V+ KL G ++ Y + KF K++ + A + + F E L L +WA+L+ +M+L+ W ++ + +L++ + ++MA + D + ++ +K+++ +L +Y+++ K LL EL W+N +CL +A ++ L H + + +WMG L +N+K+IL + F +I+ L + P + H ++SD+ LL T +V + V +S+ +RE +R+ FY A I KF+ ++Y+ FL++F + LV+++ + + E Y Y+ T E++R+ + ++EP
Sbjct: 222 LNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRN-KNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYG--QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-----ANTLGYILRDVRP-HIPKGY-----IYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF-YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ-------EWYSIAYITTLGFEKVREII--SSEP 879
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Match: Trpm (gene:FBgn0265194 transcript:FBtr0339076) HSP 1 Score: 115.931 bits (289), Expect = 3.943e-25 Identity = 149/682 (21.85%), Postives = 288/682 (42.23%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI-----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMM----NNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNE--------------DFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTIPFSFIFIKPLIIPT------FPPKKIMH--------EESDKMDSSEMKLLEKT-----EEVQYSYPVKRIESEKISYRE--------------AMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
L+ H FL D+GT+ +Y E+ R K E ++ N + +V ++ EGG + V Y + +P+V+ GSG A+L+A V + + ++ + L+ Q FE + + L + R K I ++ + + D+ IL A+ + S + L L + + IA +F Q+ +++ + L+ +R +F++L +EN ++KF+ L +LY P A L + R R + K + L+ IG V+ KL G ++ Y + KF K++ + A + + F E L L +WA+L+ +M+L+ W ++ + +L++ + ++MA + D + ++ +K+++ +L +Y+++ K LL EL W+N +CL +A ++ L H + + +WMG L +N+K+IL + F +I+ L + P + H ++SD+ LL T +V + V +S+ +RE +R+ FY A I KF+ ++Y+ FL++F + LV+++ + + E Y Y+ T E++R+ + ++EP
Sbjct: 222 LNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRN-KNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYG--QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-----ANTLGYILRDVRP-HIPKGY-----IYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF-YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ-------EWYSIAYITTLGFEKVREII--SSEP 879
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Match: Trpm (gene:FBgn0265194 transcript:FBtr0339074) HSP 1 Score: 115.546 bits (288), Expect = 4.683e-25 Identity = 149/682 (21.85%), Postives = 288/682 (42.23%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI-----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMM----NNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNE--------------DFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTIPFSFIFIKPLIIPT------FPPKKIMH--------EESDKMDSSEMKLLEKT-----EEVQYSYPVKRIESEKISYRE--------------AMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
L+ H FL D+GT+ +Y E+ R K E ++ N + +V ++ EGG + V Y + +P+V+ GSG A+L+A V + + ++ + L+ Q FE + + L + R K I ++ + + D+ IL A+ + S + L L + + IA +F Q+ +++ + L+ +R +F++L +EN ++KF+ L +LY P A L + R R + K + L+ IG V+ KL G ++ Y + KF K++ + A + + F E L L +WA+L+ +M+L+ W ++ + +L++ + ++MA + D + ++ +K+++ +L +Y+++ K LL EL W+N +CL +A ++ L H + + +WMG L +N+K+IL + F +I+ L + P + H ++SD+ LL T +V + V +S+ +RE +R+ FY A I KF+ ++Y+ FL++F + LV+++ + + E Y Y+ T E++R+ + ++EP
Sbjct: 240 LNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRN-KNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYG--QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-----ANTLGYILRDVRP-HIPKGY-----IYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF-YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ-------EWYSIAYITTLGFEKVREII--SSEP 897
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Match: Trpm (gene:FBgn0265194 transcript:FBtr0339079) HSP 1 Score: 115.161 bits (287), Expect = 6.328e-25 Identity = 149/682 (21.85%), Postives = 288/682 (42.23%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI-----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMM----NNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNE--------------DFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTIPFSFIFIKPLIIPT------FPPKKIMH--------EESDKMDSSEMKLLEKT-----EEVQYSYPVKRIESEKISYRE--------------AMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
L+ H FL D+GT+ +Y E+ R K E ++ N + +V ++ EGG + V Y + +P+V+ GSG A+L+A V + + ++ + L+ Q FE + + L + R K I ++ + + D+ IL A+ + S + L L + + IA +F Q+ +++ + L+ +R +F++L +EN ++KF+ L +LY P A L + R R + K + L+ IG V+ KL G ++ Y + KF K++ + A + + F E L L +WA+L+ +M+L+ W ++ + +L++ + ++MA + D + ++ +K+++ +L +Y+++ K LL EL W+N +CL +A ++ L H + + +WMG L +N+K+IL + F +I+ L + P + H ++SD+ LL T +V + V +S+ +RE +R+ FY A I KF+ ++Y+ FL++F + LV+++ + + E Y Y+ T E++R+ + ++EP
Sbjct: 229 LNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRN-KNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYG--QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGP-----ANTLGYILRDVRP-HIPKGY-----IYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPF-YIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ-------EWYSIAYITTLGFEKVREII--SSEP 886
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Match: trpm2 (transient receptor potential cation channel, subfamily M, member 2 [Source:NCBI gene;Acc:799412]) HSP 1 Score: 149.443 bits (376), Expect = 2.656e-35 Identity = 163/660 (24.70%), Postives = 306/660 (46.36%), Query Frame = 2
Query: 1460 F*YYYKSPLINEKGKHTLDGL---HDNFLFCDDGTEKQYDREVEFRLKFENY-----LKNKTDAF---LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNE--NQHLFEKSKG----EITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI-------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFI-NDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLD--ILYIIGKVVQKLSGNVIKNLY--EKYKFSTEKNKL-ILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEK--KFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILT-IPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKR--------IESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQF 3316
F YY ++E+G+ L L H +FL DDGT+ Y E+E R + E L N+ +V ++ +GG + +Y + + P V+++GSG +A++IA V +P SK AL+N + ++ K +I E+ + +I R V + N D IL+A++ + ++ L+L + + IA +F++ Q S MF + L ++PEF+ L +EN V +F+ +E L +LY S P C L +L + + + E L + + V+ L G+ + LY +YK + + +L + + + L ++ D + G ++LFLWA++ E++ + W+ +D I +AL AS ILR +A + G+++ E+ + E + Y+ ++ + +E + + + LLIR W +TCL +A + F+ HS ++ +T++W GELS +WK++L I F I+ L TF + + ++++ + ++ +E Q +KR E + ++ + F + VKFY + SY FL +F + +++ + + E+ +Y+++ + +CEEIRQ
Sbjct: 232 FPAYYS---LDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVVLEGSGRLADVIAHVASVPVSK---VTMALINRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFRIDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAESEIFTEES-QWTSSDLHPAMF-SALVGDKPEFVRLLLENGVCVREFLEREETLCELY--SHLPS---CF-FLRKLAKRVQGGKMRRGQEPLPGSRKVCLSHVSEEVRHLLGSFTQPLYIASRYKPTKDDVRLKVPSKGALDLPCSGEEWSADTVWDPG------RDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQ---ESGEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALLTQIWCGELSVDNPHWKVLLCMIFFPLIYTGFL---TFRRDEDIQRQAERTEQQKLA-MESVFAGQSDGKIKRHLRGFSQKSELKPLNCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMIDFQTSPSWR-------ELLLYVWLTSLVCEEIRQL 857
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Match: trpm6 (transient receptor potential cation channel, subfamily M, member 6 [Source:ZFIN;Acc:ZDB-GENE-111212-1]) HSP 1 Score: 143.28 bits (360), Expect = 2.479e-33 Identity = 151/673 (22.44%), Postives = 301/673 (44.73%), Query Frame = 2
Query: 1502 KHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHV--YTVLNDEIPIVIVKGSGGIANLIA------SVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFST----------EKNKLILNDAEIQLNNDETSFNEDF--------YEENGLLSLNAQ------------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKK----YQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSY---PVKRIESEKISYREAMRV-------------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
+ +L+G+H +FL DDGT + ++E R + E ++ + LV ++ EGG + V Y +P+++ +G+G A+++A +V +S KE++ + ++ F + E TE ++ L E +++ I I+D + +++ D IL + G S ++ L L + + IA + + ++ ++E++ ++ L +R F++L IEN + F+ L LY I L + A+ T + L IG V++ L G ++ Y + +F T E + ++ + T F ++E G+ + + +LF+WA+L EM+L+ W+ + + A++A + R++A ++ ++N+ +E KK + L+V +L +A+++N+ LL E+K W+N TCLQ+A +S + F+ H+ + +T +WMG L+ ++W KII +I + P+ I E + + S + L+ E +Q+ + P ++ +EK + R FY A +VKF+ + ++++ FL++F Y LV L +++ E + Y+ E+ R+ L
Sbjct: 231 RASLNGMHSHFLLVDDGTIGKSGCQIELRKRLERHIHYQKIHPRLPQHVPLVCVVVEGGPSVLSVVLEYVCRTSPVPVLVFEGTGRAADMLALIHKQTAVDRKLDSDIKEDVLQRIQDS---FGVERSESTELLDILMECM-EHRELISIFDSESEDLQEADVAILSTSLRGTRASPEEQLSLTLAWDRADIAKDHILVYGQQWQVG--SLEQIMLDALIMDRVNFVKLLIENGMTMSHFLTISRLEQLYNIQTGSSH----HFLRHVIADAKQTRLPA-----VYRISLIDIGMVIEYLIGGAYRSTYTRKRFRTMYSRLHNPAKETSSPFSKAKKVAPAPEATPPRSHFRRTAQPYRHQEGGVAPQDQKSDPIPDFVCTFNDLFVWAVLKHRQEMALLLWQHGEQAMARAVVACKLYRTLA---MEAKESNMGDTMAEELKKNSLEFGQLAVDVLDQAFRENERMAMKLLTWEMKDWSNFTCLQMAVSSGLRPFVAHNCTQMLLTDLWMGRLNLSKNSWFKIIGSI------LMPVAIQLL-------EFKSQAEMSHVPQLQ--EALQFGWDTVPSEQEGAEKAVPGDEERGSSCLYPWTRKVYDFYTAPVVKFWFHTMAFLGFLMMFAYTCLVRLNETPNIQ-------ECLVMTYILAMAVEKAREVL 863
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Match: trpm5 (transient receptor potential cation channel, subfamily M, member 5 [Source:ZFIN;Acc:ZDB-GENE-060503-736]) HSP 1 Score: 133.265 bits (334), Expect = 1.836e-30 Identity = 149/651 (22.89%), Postives = 294/651 (45.16%), Query Frame = 2
Query: 1505 HTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF---------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKT------LKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKN-ENEIDLDILYIIGKVVQKLSGNVIKNLYE-KYKFSTEKNKLILNDA--------EIQLNNDETSFNEDFYEENGLLSLNAQ------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTF----PPKKIMHEESDKMDSSEMKLLEKTEEVQYS--YPVKRIESEKISYREA----MRV-------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
++LD H +F+ D+ K+ E R+K ++ + + ++ +L G ++ +Y + + IP +I+ GSGG+A+++ ++M+ L+N + EIT + + I + + ++D ++ + D IL+A++ + + LKL + + IA +FS + S + +E++ + L ++P+F+ LF++N +++F+ L++LY C +E ++ T KKN E + L +++SGN L + K++F+ + +L D +L + F+ + L ++ + +LFLWA+L EM+ FW + + + +AL+ I++ MA L E S + KY+ ++ + +E Y ++ + Y LL+R+ W+ T L IAT ++ F H ++ +TKVW G + S +++LT FI PL+ + P +++ +E + +E+ LE + + + PV S + + R +RV F+ A + F ++ Y +FL++F Y+ L++ +P AEI +Y +VFT + EEIRQ
Sbjct: 165 YSLDCNHSHFILVDE-DPKRPGATGEMRVKMLKHISLQRTGYGGTGSIEIPVLCLLVHGEPRILQKMYKNIQNSIPWLILAGSGGVADILVTLMDRGCWDADIVQELLINTFPDGLHST--EITSWTKLIQRIL-DHGHLLTVHDPEQDS-ELDTVILKALVKACKSQSQEAQDFLDELKLAVAWNRVDIAKSEIFSGDV--QWSAQDLEEVMMEALVNDKPDFVRLFVDNGVNIKQFLTYGRLQELY--------CSVSE------KNLLHTLLLKKNQERQAQL--------ARKRMSGNPNNELGDRKFRFTFHEVSKVLKDFLDDTCKGFYQKLPAERMGKGRLFHSQKNLPDMDRRCEHPWRDLFLWAILQNRQEMANYFWAMGPEAVAAALVGCKIMKEMAHLA-----TEAESARSMKNAKYEQFAMDLFSECYSNSEDRAYSLLVRKTCCWSKATVLNIATLAEAKCFFAHDGVQALLTKVWWGAMRTDTSISRLVLT-----FFIPPLVWTSLIKFNPEEQVSKDEGEPF--AELDSLETEQALLLTDGDPVAGEGSAETAARSCSATFIRVVLRRWNRFWSAPVTVFMGNVIMYFAFLILFSYVLLLDFRP---PPPYGPSAAEIILYFWVFTLVLEEIRQ 771
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Match: trpm4b.2 (transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-061214-2]) HSP 1 Score: 133.265 bits (334), Expect = 1.862e-30 Identity = 164/669 (24.51%), Postives = 298/669 (44.54%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKT------DAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME------LPNSKHKENISALVNENQHLFEKSKG------EITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGY-------NNSLDKTLKLCIRFKCPKIANRAVFS---DSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLY-QISFNPDQCQCAELL-----SELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYE-KYKF-STEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFS--ETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTI---PFSFIFI------------KPLIIPTFPP------------KKIMHE-ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREA-MRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
LD H FL DDGT + E+ FR + E+Y+ + D ++ +L G +E + L + P +++ GSGG+ANL++ ++E +P + KE+ S ++ + L K K + + ++ + IY+ K I IY+ + FD +L+ ++ NS L+L + + IA +F+ D KY+++ + + L+ N+P+F+ L I+N + ++ L LY IS D C LL + +S + Y LY + +++ L G V Y+ + K +T K K + N ++ N ++ ++ + L LF+WA+L EM++ FW++ + + +AL +L L L + + E K S E + K++ ++ + Y+ +Y LLIR+ K W + TCL++A +D F +H +S ++++W G++ + W+++L + P + K + P P K I H+ E + DS+ ++ K E IES K S+ + + F+ A + F LL Y FL ++ Y+ LV+ KP ++E +Y +VFT +CEEIR+
Sbjct: 230 LDNNHKAFLLVDDGTTGRKGGELAFRARLEDYISRQRPGNASIDIPVLNMLIAGDTSMLEFLEMSLKNSTPCLVLAGSGGLANLVSDIVENVQSAAMPGASEKEDASPIMELREQLAAKVKKYFPAEKKTDKLVDKVLSIYQN-KDIISIYNAEQEGAEDFDIVMLKVLVQASKRNVSENTNSYADELRLAVTWNRVDIAKSELFNGHIDWKYEEL-----KDSMTDALENNKPQFVRLLIDNGLNISTYLTYNRLEILYNSIS---DTCLAKTLLLHHLNERIHQSIKQIYKIS----------LYEVSQLLTDLFGEVCLPFYKAELKLEATTKRKALKNACDVL--NGSCTYRDEKCKHPWLC------LFIWAVLQNRREMAIFFWEMCGESVLTALAGCKLL-----LELSKQEIETEAKLSMKELALKFEQMAHDVFGTCYQTKASHSYKLLIRKSKLWGDATCLKMAIAADARIFFSHDGVQSLLSQIWWGDIERGTAFWRLLLVMICPPLCYTNCIEFRKTDPAKEEKSMTAPPSSPTDSHYEKTVYSFKDIKHQNEGENEDSNHIRQNTKGEPA-------FIESMKSSFVVSRWKQFWYAPVTSFIGNLLMYFLFLFLYAYVLLVDFKP---PPPDGPAVSEYVLYFWVFTLVCEEIRE 856
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Match: trpm5 (transient receptor potential cation channel, subfamily M, member 5 [Source:ZFIN;Acc:ZDB-GENE-060503-736]) HSP 1 Score: 132.88 bits (333), Expect = 2.137e-30 Identity = 149/651 (22.89%), Postives = 294/651 (45.16%), Query Frame = 2
Query: 1505 HTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF---------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKT------LKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKN-ENEIDLDILYIIGKVVQKLSGNVIKNLYE-KYKFSTEKNKLILNDA--------EIQLNNDETSFNEDFYEENGLLSLNAQ------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTF----PPKKIMHEESDKMDSSEMKLLEKTEEVQYS--YPVKRIESEKISYREA----MRV-------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
++LD H +F+ D+ K+ E R+K ++ + + ++ +L G ++ +Y + + IP +I+ GSGG+A+++ ++M+ L+N + EIT + + I + + ++D ++ + D IL+A++ + + LKL + + IA +FS + S + +E++ + L ++P+F+ LF++N +++F+ L++LY C +E ++ T KKN E + L +++SGN L + K++F+ + +L D +L + F+ + L ++ + +LFLWA+L EM+ FW + + + +AL+ I++ MA L E S + KY+ ++ + +E Y ++ + Y LL+R+ W+ T L IAT ++ F H ++ +TKVW G + S +++LT FI PL+ + P +++ +E + +E+ LE + + + PV S + + R +RV F+ A + F ++ Y +FL++F Y+ L++ +P AEI +Y +VFT + EEIRQ
Sbjct: 214 YSLDCNHSHFILVDE-DPKRPGATGEMRVKMLKHISLQRTGYGGTGSIEIPVLCLLVHGEPRILQKMYKNIQNSIPWLILAGSGGVADILVTLMDRGCWDADIVQELLINTFPDGLHST--EITSWTKLIQRIL-DHGHLLTVHDPEQDS-ELDTVILKALVKACKSQSQEAQDFLDELKLAVAWNRVDIAKSEIFSGDV--QWSAQDLEEVMMEALVNDKPDFVRLFVDNGVNIKQFLTYGRLQELY--------CSVSE------KNLLHTLLLKKNQERQAQL--------ARKRMSGNPNNELGDRKFRFTFHEVSKVLKDFLDDTCKGFYQKLPAERMGKGRLFHSQKNLPDMDRRCEHPWRDLFLWAILQNRQEMANYFWAMGPEAVAAALVGCKIMKEMAHLA-----TEAESARSMKNAKYEQFAMDLFSECYSNSEDRAYSLLVRKTCCWSKATVLNIATLAEAKCFFAHDGVQALLTKVWWGAMRTDTSISRLVLT-----FFIPPLVWTSLIKFNPEEQVSKDEGEPF--AELDSLETEQALLLTDGDPVAGEGSAETAARSCSATFIRVVLRRWNRFWSAPVTVFMGNVIMYFAFLILFSYVLLLDFRP---PPPYGPSAAEIILYFWVFTLVLEEIRQ 820
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Match: TRPM6 (transient receptor potential cation channel, subfamily M, member 6 [Source:NCBI gene;Acc:100487366]) HSP 1 Score: 165.236 bits (417), Expect = 5.053e-40 Identity = 169/681 (24.82%), Postives = 312/681 (45.81%), Query Frame = 2
Query: 1484 LINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGR----MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLN----------NDETSFNEDFY-------------------EENGLLSL--NAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-----SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTI---PFSFIF-IKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKIS-------YREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
LIN K T L+ +H +F+ DDGT +Y E++ R E+++ + +V ++ EGG M E+V + +P+V+ +G+G A+++A + + + KE I ++ + +L + + YI C +R+I I+D + + D IL A++ G N S L L + + IA + + ++ K+ ++E+ + L +R +F++L IE + +F+ L +LY P LL L R K++ D I I +G V++ L G ++ Y + F N L N + + +N + E++ + F+ E+N + +L +WA+L +M++ FW+ ++ + A++A + R+MA S M+ L+K SK++ L++ IL A+K N+ LL +LK W+N+TCL++A +S + F++H+ + +T +WMG L +W K+IL I PF + K + P+ + + ++ L K E + V+ +++KIS + FY A IVKF+ + + Y++FL++F Y LV++ P V+ E + IY+FT E++R+ +EP
Sbjct: 227 LINPMSKLTSLNSMHSHFIMVDDGTVGKYGNEMKLRRNLEDFISLQKIHTRMGQGVPVVGLVIEGGPNVILMVWEYVRS--TPPVPVVVCEGTGRAADILAFTHKQISPQLKEEILEMIQKTFNLGHRQSNHVL-YILMEC-----MERRITIFDAESEEQQDIDLAILTALLKGTNMSAQDQLSLALTWNRVDIAKKHILIYGQHWKVG--SLEQAMQDALVMDRVDFVKLLIEYGVNMHRFLTIGHLEELYNTKQGPTNL----LLHHLVRDV------KQSNPSPDYRISLIDVGLVIEYLIGGAYRSSYTRKSFRVLYNSLFRNLSHLSINQSSQMSSKLESPESTLHSQFFRTAQPCRRKSKKKDEVTCTEDNEPVGFIYPYNDLLVWAVLMKRQKMAMFFWQHGEEAMVKAVIACKLYRAMAHEAKQSTMVDDTSEELKK----YSKEFGQLALDILENAFKMNEQMAMKLLTYQLKNWSNSTCLKLAVSSTLRPFVSHTCTQMLLTDMWMGRLKMRKHSWLKVILGILLPPFVLMLEFKTKAEMSHVPQSLEFHQFSRLYVDPPSLSTKEEHIT----VREDQNQKISNGLGILPITRKICEFYSAPIVKFWFHTMVYLAFLMLFTYTVLVKMDPQPSVQ-------EWCVIIYIFTTAVEKVREVF--VSEPG 870
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Match: shc2 (SHC (Src homology 2 domain containing) transforming protein 2 [Source:Xenbase;Acc:XB-GENE-6073771]) HSP 1 Score: 158.688 bits (400), Expect = 3.546e-38 Identity = 158/649 (24.35%), Postives = 285/649 (43.91%), Query Frame = 2
Query: 1505 HTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-KNKTDAFLVQILFEGGR--------------MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILG-YNNSLDKT-----LKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDI-----------LYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLI---IPTFPPKKIMHEES-DKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELK-PLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
++LD + FL DDGT Q E FR + E ++ + KT A GGR + + VY IP ++V GSGG+A+ +A ++E S E+I L+ E +H F E + + E + + + +Y + F+ IL+A++ +S D LKL + + IA +F K + ++ + L N+P+F++LF++N + ++ L +LY + LL +L +S + K ++ +L LY + K+++ L G+V Y +L + + +N + + + +LF+WA+L EM+ FW++ + + SAL A IL+ + S M + +L + + + K++ L++ + E Y+ ++ + + LL+R W TCLQ+A +D F +S +T+ W G+++ W ++LT F PLI + TF K I HE + EM L+ +K ++ + + + F+ A + F+ ++ Y +FL +F Y+ L+E K P D + +E +Y ++FT +CEEIRQ T P
Sbjct: 132 YSLDNNYSVFLLADDGTHGQMGGETSFRFRLEEHISRQKTGA--------GGRFDYGPLNDNRNVAILYFQRVYNATKSPIPCLLVAGSGGVADCLAEILE--ESIALESIRGLIEEKLKHYFP------NENLTKMVERIVENRDLVTVYSDADGIEDFETVILKALVKACKKHSSDAVEYLDELKLAVAWNREDIAKTELFHGEILWKAT--DLDDTMTDALINNKPKFVKLFVDNGLNIVDYLTYGRLEELYSSVLD------NTLLYQLLKSKHDEHRNSKTKDHHELLFMESNGKGREFKLYEVSKILRDLLGDVCTTFYTH----------VLGNMKGSVNKRNSGYQPRKSTSPWI------DLFIWAILQNRDEMATYFWEMGSEAVTSALAAMKILKEL-SRMESEAEESLAMR--DLAAKFEQLAIGVFNECYRNSENRAFKLLVRRSVIWGGATCLQLAYEADARNFFAQDGVQSMLTENWWGQMAQNTPVWAMVLT-----FFCPPLIYTDLITF--KSIDHENGIESAQRMEMDSLDTD--------IKTTVKQRPRWMQRWKQFWSAPVTAFFGNVVMYFAFLFLFSYVLLLEFKMPPPDGPAN----SEFILYFWIFTMVCEEIRQSFFVGTMP 718
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Match: TRPM6 (transient receptor potential cation channel, subfamily M, member 6 [Source:NCBI gene;Acc:100487366]) HSP 1 Score: 159.458 bits (402), Expect = 3.772e-38 Identity = 166/679 (24.45%), Postives = 306/679 (45.07%), Query Frame = 2
Query: 1484 LINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGR----MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELP---NSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFY---------------------------EENGLLSL--NAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-----SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRV-------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
LIN K T L+ +H +F+ DDGT +Y E++ R E+++ + +V ++ EGG M E+V + +P+V+ +G+G A+++A + + + KE I ++ + +L + + YI C + + I I+D + + D IL A++ G N S L L + + IA + + ++ K+ ++E+ + L +R +F++L IE + +F+ L +LY P LL L R K++ D I I +G V++ L G ++ Y + F N L N +L + E++ + F+ E+N + +L +WA+L +M++ FW+ ++ + A++A + R+MA S M+ L+K SK++ L++ IL A+K N+ LL +LK W+N+TCL++A +S + F++H+ + +T +WMG L +W K+IL I + P ++ F K M ++ + L + + S +++KIS + FY A IVKF+ + + Y++FL++F Y LV++ P V+ E + IY+FT E++R+ +EP
Sbjct: 227 LINPMSKLTSLNSMHSHFIMVDDGTVGKYGNEMKLRRNLEDFISLQKIHTRMGQGVPVVGLVIEGGPNVILMVWEYVRS--TPPVPVVVCEGTGRAADILAFTHKHTTDTDPQLKEEILEMIQKTFNLGHRQSNHVL-YILMEC---MERRASITIFDAESEEQQDIDLAILTALLKGTNMSAQDQLSLALTWNRVDIAKKHILIYGQHWKVG--SLEQAMQDALVMDRVDFVKLLIEYGVNMHRFLTIGHLEELYNTKQGPTNL----LLHHLVRDV------KQSNPSPDYRISLIDVGLVIEYLIGGAYRSSYTRKSFRVLYNSLFRNQMSSKLESPESTLHSQFFRTAQPCRRKDKTTCHQKSKKKDEVTCTEDNEPVGFIYPYNDLLVWAVLMKRQKMAMFFWQHGEEAMVKAVIACKLYRAMAHEAKQSTMVDDTSEELKK----YSKEFGQLALDILENAFKMNEQMAMKLLTYQLKNWSNSTCLKLAVSSTLRPFVSHTCTQMLLTDMWMGRLKMRKHSWLKVILG-----ILLPPFVLMLEFKTKAEMSHVPQSLEFHQFSRLYDFDAERGSKQPGEDQNQKISNGLGILPITRKICEFYSAPIVKFWFHTMVYLAFLMLFTYTVLVKMDPQPSVQ-------EWCVIIYIFTTAVEKVREVF--VSEPG 869
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Match: shc2 (SHC (Src homology 2 domain containing) transforming protein 2 [Source:Xenbase;Acc:XB-GENE-6073771]) HSP 1 Score: 158.303 bits (399), Expect = 5.544e-38 Identity = 163/654 (24.92%), Postives = 293/654 (44.80%), Query Frame = 2
Query: 1505 HTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-KNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYN-NSLDKT-----LKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDI-----------LYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLI---IPTFPPKKIMHEE------SDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELK-PLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
++LD + FL DDGT Q E FR + E ++ + KT A ++ +L G + VY IP ++V GSGG+A+ +A ++E S E+I L+ E +H F E + + E + + + +Y + F+ IL+A++ +S D LKL + + IA +F K + ++ + L N+P+F++LF++N + ++ L +LY + LL +L +S + K ++ +L LY + K+++ L G+V Y +L + + +N + + + LF+WA+L EM+ FW++ + + SAL A IL+ + S M + +L + + + K++ L++ + E Y+ ++ + + LL+R W TCLQ+A +D F +S +T+ W G+++ W ++LT F PLI + TF + + EE +K D++E L+K V+ S K E+E I ++ R F+ A + F+ ++ Y +FL +F Y+ L+E K P D + +E +Y ++FT +CEEIRQ T P
Sbjct: 225 YSLDNNYSVFLLADDGTHGQMGGETSFRFRLEEHISRQKTGAGGKGSIEIPVLCMLIAGESKMLGRVYNATKSPIPCLLVAGSGGVADCLAEILE--ESIALESIRGLIEEKLKHYFP------NENLTKMVERIVENRDLVTVYSDADGIEDFETVILKALVKACKKHSSDAVEYLDELKLAVAWNREDIAKTELFHGEILWKAT--DLDDTMTDALINNKPKFVKLFVDNGLNIVDYLTYGRLEELYSSVLD------NTLLYQLLKSKHDEHRNSKTKDHHELLFMESNGKGREFKLYEVSKILRDLLGDVCTTFYTH----------VLGNMKGSVNKRNSGSTSPWID-----------LFIWAILQNRDEMATYFWEMGSEAVTSALAAMKILKEL-SRMESEAEESLAMR--DLAAKFEQLAIGVFNECYRNSENRAFKLLVRRSVIWGGATCLQLAYEADARNFFAQDGVQSMLTENWWGQMAQNTPVWAMVLT-----FFCPPLIYTDLITF-NRTLSSEELYFSFREEKDDNAEEVPLKKM-SVKKSKTKKAPEAEIIKEKQRPRWMQRWKQFWSAPVTAFFGNVVMYFAFLFLFSYVLLLEFKMPPPDGPAN----SEFILYFWIFTMVCEEIRQSFFVGTMP 827
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Match: TRPM6 (transient receptor potential cation channel, subfamily M, member 6 [Source:NCBI gene;Acc:100487366]) HSP 1 Score: 158.688 bits (400), Expect = 5.545e-38 Identity = 166/678 (24.48%), Postives = 304/678 (44.84%), Query Frame = 2
Query: 1484 LINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGR----MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELP---NSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFY---------------------------EENGLLSL--NAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-----SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTI---PFSFIF-IKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRV---FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
LIN K T L+ +H +F+ DDGT +Y E++ R E+++ + +V ++ EGG M E+V + +P+V+ +G+G A+++A + + + KE I ++ + +L + + YI C + + I I+D + + D IL A++ G N S L L + + IA + + ++ K+ ++E+ + L +R +F++L IE + +F+ L +LY P LL L R K++ D I I +G V++ L G ++ Y + F N L N +L + E++ + F+ E+N + +L +WA+L +M++ FW+ ++ + A++A + R+MA S M+ L+K SK++ L++ IL A+K N+ LL +LK W+N+TCL++A +S + F++H+ + +T +WMG L +W K+IL I PF + K + P+ + + ++ L K E + + S + R FY A IVKF+ + + Y++FL++F Y LV++ P V+ E + IY+FT E++R+ +EP
Sbjct: 227 LINPMSKLTSLNSMHSHFIMVDDGTVGKYGNEMKLRRNLEDFISLQKIHTRMGQGVPVVGLVIEGGPNVILMVWEYVRS--TPPVPVVVCEGTGRAADILAFTHKHTTDTDPQLKEEILEMIQKTFNLGHRQSNHVL-YILMEC---MERRASITIFDAESEEQQDIDLAILTALLKGTNMSAQDQLSLALTWNRVDIAKKHILIYGQHWKVG--SLEQAMQDALVMDRVDFVKLLIEYGVNMHRFLTIGHLEELYNTKQGPTNL----LLHHLVRDV------KQSNPSPDYRISLIDVGLVIEYLIGGAYRSSYTRKSFRVLYNSLFRNQMSSKLESPESTLHSQFFRTAQPCRRKDKTTCHQKSKKKDEVTCTEDNEPVGFIYPYNDLLVWAVLMKRQKMAMFFWQHGEEAMVKAVIACKLYRAMAHEAKQSTMVDDTSEELKK----YSKEFGQLALDILENAFKMNEQMAMKLLTYQLKNWSNSTCLKLAVSSTLRPFVSHTCTQMLLTDMWMGRLKMRKHSWLKVILGILLPPFVLMLEFKTKAEMSHVPQSLEFHQFSRLYVDPPSLSTKEEHITPGEDQNQKISNGLGILPITRKICEFYSAPIVKFWFHTMVYLAFLMLFTYTVLVKMDPQPSVQ-------EWCVIIYIFTTAVEKVREVF--VSEPG 873
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Match: Trpm2 (transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901]) HSP 1 Score: 200.29 bits (508), Expect = 7.310e-51 Identity = 159/640 (24.84%), Postives = 306/640 (47.81%), Query Frame = 2
Query: 1484 LINEKGKH---TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
+++E+G+ LD H +F+ DDGT QY E+ R K E ++ +T +V ++ EGG + +Y +N+ P VIV+GSG +A++IA V LP S E +L+ + Q +FE ++ +I E+ + +I R+ + + + + D IL+A++ G+ N D LKL + + IA +F+D K + + M L N+PEF+ LF+EN +++F+ + L LY+ + P ++L L R Y + ++ + +V+++L G+ + LY + ++ T++ +L + I+LN S + G ++ ++L +WA++ E++ + W ++D +AL S IL+ ++ + ++ + +++ ++ + TE Y+K++ + LL+R + W TTCLQ+A + ++F++H ++++TKVW G+L W+IIL + +F PL+ F S+ KR+++ + +R F+ A +V F++ +LSY +FL +F Y+ +V+ +P E IY+++F+ +CEE RQ
Sbjct: 264 MLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAINNGTPCVIVEGSGRVADVIAQVATLPVS---EITISLIQQKLSIFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDEWQWKPA--DLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYE-NLEPSCLFHSKLQKVLAEEQRLAYASATPRLH-----MHHVAQVLRELLGDSTQLLYPRPRY-TDRPRLSMTVPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAVIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEED---TDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCM-LAF----PLLFTGF----------------------------ISFREKRLQA--LCRPARVRAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQP-------SPSWCEYLIYLWLFSLVCEETRQLF 845
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Match: Trpm4 (transient receptor potential cation channel, subfamily M, member 4 [Source:MGI Symbol;Acc:MGI:1915917]) HSP 1 Score: 152.525 bits (384), Expect = 2.906e-36 Identity = 153/649 (23.57%), Postives = 287/649 (44.22%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-KNKT-------DAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME---LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQ--IVIYDMMNNNMKFDKKILEAMILGYNNS-----LDKTLKLCIRFKCPKIANRAVF-SDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNV------IKNLYEKY--KFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIE-SEKIS-----------------YREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
LD + F DDGT + E FRL+FE+Y+ + KT D ++ +L +G ++ + ++P ++V GSGG A+ + +E P S A + + F K E+ + ++ R R+ + +Y + + +F+ +L A++ +S LD+ L+L + + IA +F D +++ +E ++ L +RPEF+ L I + + F+ L LY + +P+ L+ L A +K +++ +G+V++ L G +N + Y + E + L+++ A Q + D SF + + +L +WALL +M++ FW+ + + SAL A +LR MA L + + K + T ++ +SV + E Y ++ + LL+R W TCLQ+A +D F +S +T+ W GE+ W ++L F PLI I+ +S++ + + + + + P +E S K++ + + F+GA + F ++SY+ FLL+F ++ LV+ +P K ++E+ +Y + FT +CEE+RQ L
Sbjct: 226 LDYNYSAFFLVDDGTYGRLGGENRFRLRFESYVAQQKTGVGGTGIDIPVLLLLIDGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEAR-DRIRRYFPKGDPEVLQ-----AQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEASAYLDE-LRLAVAWNRVDIAQSELFRGDIQWRSFH---LEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYS-AVSPNS-----LIRNLLDQASHASSSKSPPVNGTVELRPPNVGQVLRTLLGETCAPRYPARNTRDSYLGQDHRENDSLLMDWANKQPSTD-ASFEQAPWS----------DLLIWALLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLESEAEEAARRKDLAAT---FESMSVDLFGECYHNSEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDSTTPIWALLLA-----FFCPPLIYTNL----IVFRKSEEEPTQKDLDFDMDSSINGAGPPGTVEPSAKVALERRQRRRPGRALCCGKFSKRWSDFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQP------TKPSVSELLLYFWAFTLLCEELRQGL 829
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Match: Trpm4 (transient receptor potential cation channel, subfamily M, member 4 [Source:MGI Symbol;Acc:MGI:1915917]) HSP 1 Score: 151.754 bits (382), Expect = 3.342e-36 Identity = 153/649 (23.57%), Postives = 287/649 (44.22%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-KNKT-------DAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME---LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQ--IVIYDMMNNNMKFDKKILEAMILGYNNS-----LDKTLKLCIRFKCPKIANRAVF-SDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNV------IKNLYEKY--KFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIE-SEKIS-----------------YREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
LD + F DDGT + E FRL+FE+Y+ + KT D ++ +L +G ++ + ++P ++V GSGG A+ + +E P S A + + F K E+ + ++ R R+ + +Y + + +F+ +L A++ +S LD+ L+L + + IA +F D +++ +E ++ L +RPEF+ L I + + F+ L LY + +P+ L+ L A +K +++ +G+V++ L G +N + Y + E + L+++ A Q + D SF + + +L +WALL +M++ FW+ + + SAL A +LR MA L + + K + T ++ +SV + E Y ++ + LL+R W TCLQ+A +D F +S +T+ W GE+ W ++L F PLI I+ +S++ + + + + + P +E S K++ + + F+GA + F ++SY+ FLL+F ++ LV+ +P K ++E+ +Y + FT +CEE+RQ L
Sbjct: 79 LDYNYSAFFLVDDGTYGRLGGENRFRLRFESYVAQQKTGVGGTGIDIPVLLLLIDGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEAR-DRIRRYFPKGDPEVLQ-----AQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEASAYLDE-LRLAVAWNRVDIAQSELFRGDIQWRSFH---LEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYS-AVSPNS-----LIRNLLDQASHASSSKSPPVNGTVELRPPNVGQVLRTLLGETCAPRYPARNTRDSYLGQDHRENDSLLMDWANKQPSTD-ASFEQAPWS----------DLLIWALLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLESEAEEAARRKDLAAT---FESMSVDLFGECYHNSEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDSTTPIWALLLA-----FFCPPLIYTNL----IVFRKSEEEPTQKDLDFDMDSSINGAGPPGTVEPSAKVALERRQRRRPGRALCCGKFSKRWSDFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQP------TKPSVSELLLYFWAFTLLCEELRQGL 682
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Match: Trpm6 (transient receptor potential cation channel, subfamily M, member 6 [Source:MGI Symbol;Acc:MGI:2675603]) HSP 1 Score: 150.599 bits (379), Expect = 1.390e-35 Identity = 174/694 (25.07%), Postives = 307/694 (44.24%), Query Frame = 2
Query: 1508 TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLK-------NKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISAL---VNEN-----QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDM-MNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSE-----LCRSARTTYFTKKNENEIDLDILYIIGKV-----VQKLSGNVIKNLYEKYK----FSTEKNKLILNDAEIQLNNDETS---FNEDFYE----------------------ENGLLSLNAQ---------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQD----LSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMD------SSEMKL-------------LEKTEEVQYSYPVK---RIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
TL+ +H +F+ CDDGT Y E + R E +L ++ +V ++ EGG + V+ + ++ P+V+ +G+G A+L+A KH E+ L V E Q++F S + L E +K I I+D + D IL A++ G + S+ + L L + + IA + + + ++ K +E+ ++ L +R +F++L IEN + +F+ L +LY P L+ + L S R T +I L I Y+IG +K + NLY K+K F+ ++ L+ N E+S + F+ E LS + +L +WA+L M++ FW+ ++ A++AS + R+MA + ++N+ SE K Y + L++ +L +A+K+N+ LL ELK W+N+TCL++A + + F++HS + +T +WMG L ++W KII++ I + P+I+ F K M D S+ L LE+ + + P+ R + + + + FY A VKF+ Y ++Y++FL++F Y LVE++P V E + IY+FT E++R+
Sbjct: 231 TLNCMHSHFILCDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVMEGGPNVILWVWETVKNKEPVVVCEGTGRAADLLAFTY-----KHLEDGGILRPQVKEELFCLIQNMFNFSLRQSKHLFQILMECM-VHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHILTYGQHWKPG--ALEQAMLDALVMDRVDFVKLLIENGVNLHRFLTIPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLI------DIGLVIEYLIGGAYRSSYTRKSFRILYNNLYRKHKSVSSFAQGLSQHSLHQRHSLRNRKESSESTLHSQFFRTAQPYKSKEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEATVKAVIASILYRAMAR---EAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIIS-----ILLPPMILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPLHLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVH-------EWLVIIYIFTNAIEKVRE 895
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Match: Trpm3 (transient receptor potential cation channel, subfamily M, member 3 [Source:MGI Symbol;Acc:MGI:2443101]) HSP 1 Score: 146.362 bits (368), Expect = 2.868e-34 Identity = 162/662 (24.47%), Postives = 293/662 (44.26%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLND--EIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN---------QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMN-NNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFST--------EKNKLILNDAEIQLNNDETSFNEDFYE-ENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRG-DNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTI--PFSFI---FIKPLIIPTFPPKKIMHEE----------SDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRV------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
L+ +H +F+ D+GT +Y EV+ R + E ++ + +V ++ EGG + V L D +P+V+ GSG ++++A K+ E L+NE+ Q F ++ + L E +K K I ++ M + + D IL A++ G N S L L + + IA +F + + ++E+ ++ L +R +F++L IEN + +F+ L +LY P + L L R KK D I I IG V++ L G + Y + +F T +++ + L E + D + E L +WA+L +M+L FW+ ++ + AL+A + ++MA + +++ ++ + S+ + L+V +L ++YK+++ LL ELK W+N TCLQ+A + +F+ H+ + +T +WMG L S K+IL I P S + F +P + +H + + + D +M+L K+ E E S + V FY A IVKF+ Y L+Y+ +L++F Y+ LV+++ + E + Y+FT E++R+ L +EP
Sbjct: 287 LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAF-----GHKYSEE-GGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKK-KELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVG--SLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGP-----SNTLYHLVRD------VKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRSNGESSRKKDEEEVQSRHRLIPVGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQ-------EWIVISYIFTLGIEKMREIL--MSEPG 919
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Match: sp|Q91YD4|TRPM2_MOUSE (Transient receptor potential cation channel subfamily M member 2 OS=Mus musculus OX=10090 GN=Trpm2 PE=1 SV=2) HSP 1 Score: 200.29 bits (508), Expect = 5.113e-50 Identity = 159/640 (24.84%), Postives = 306/640 (47.81%), Query Frame = 2
Query: 1484 LINEKGKH---TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
+++E+G+ LD H +F+ DDGT QY E+ R K E ++ +T +V ++ EGG + +Y +N+ P VIV+GSG +A++IA V LP S E +L+ + Q +FE ++ +I E+ + +I R+ + + + + D IL+A++ G+ N D LKL + + IA +F+D K + + M L N+PEF+ LF+EN +++F+ + L LY+ + P ++L L R Y + ++ + +V+++L G+ + LY + ++ T++ +L + I+LN S + G ++ ++L +WA++ E++ + W ++D +AL S IL+ ++ + ++ + +++ ++ + TE Y+K++ + LL+R + W TTCLQ+A + ++F++H ++++TKVW G+L W+IIL + +F PL+ F S+ KR+++ + +R F+ A +V F++ +LSY +FL +F Y+ +V+ +P E IY+++F+ +CEE RQ
Sbjct: 264 MLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAINNGTPCVIVEGSGRVADVIAQVATLPVS---EITISLIQQKLSIFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDEWQWKPA--DLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYE-NLEPSCLFHSKLQKVLAEEQRLAYASATPRLH-----MHHVAQVLRELLGDSTQLLYPRPRY-TDRPRLSMTVPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAVIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEED---TDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCM-LAF----PLLFTGF----------------------------ISFREKRLQA--LCRPARVRAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQP-------SPSWCEYLIYLWLFSLVCEETRQLF 845
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Match: sp|E9PTA2|TRPM2_RAT (Transient receptor potential cation channel subfamily M member 2 OS=Rattus norvegicus OX=10116 GN=Trpm2 PE=1 SV=3) HSP 1 Score: 199.134 bits (505), Expect = 1.418e-49 Identity = 162/643 (25.19%), Postives = 309/643 (48.06%), Query Frame = 2
Query: 1484 LINEKGKH---TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPD---QCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
+++E+G+ LD H +F+ DDGT QY E+ R K E ++ +T +V ++ EGG + +Y + + P VIV+GSG +A++IA V LP S E +L+ + Q +FE ++ +I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F+D K S + M L N+PEF+ LF+EN +++F+ + L LY+ + P + ++L+E R Y ++ + ++ + +V+++L G+ + LY + ++ T++ +L L I+LN S + G ++ ++L +WA++ E++ + W ++D +AL S IL+ ++ + ++ + +++ ++ + TE Y+K++ + LL+R + W TTCLQ+A + ++F++H ++++TKVW G+L W+IIL + +F PL+ F S+ KR+++ + +R F+ A +V FY+ +LSY +FL +F Y+ +V+ +P E IY+++F+ +CEE RQ
Sbjct: 264 MLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAITNGTPCVIVEGSGRVADVIAQVAALPVS---EITISLIQQKLSVFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDEWQWKPS--DLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYE-NLEPSCLFHSKLQKVLAE--EHERLAYASETPRLQ-----MHHVAQVLRELLGDSTQLLYPRPRY-TDRPRLSLPMPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAIIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEED---TDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCM-LAF----PLLFTGF----------------------------ISFREKRLQA--LCRLARVRAFFNAPVVIFYLNILSYFAFLCLFAYVLMVDFQP-------SPSWCEYLIYLWLFSLVCEETRQLF 846
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Match: sp|O94759|TRPM2_HUMAN (Transient receptor potential cation channel subfamily M member 2 OS=Homo sapiens OX=9606 GN=TRPM2 PE=1 SV=2) HSP 1 Score: 173.326 bits (438), Expect = 1.032e-41 Identity = 157/671 (23.40%), Postives = 301/671 (44.86%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKH-----KENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQ---------------ISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNA---QNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E G+ L D H +F+ DDGT QY E+ R + E ++ +T +V ++ EGG + + + P V+V+GSG +A++IA V LP S ++ +S E F +S+ I E+ + +I R+ + V + + D IL+A++ G+ N D LKL + + IA +F D K S + L N+PEF++LF+EN ++++F+ + L LY+ + +P++ CA L ++ + +V+++L G+ + LY + + + ++ +L+L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + +E +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++ L + +F PL++ S+ KR++ A F +V F++ +LSY +FL +F Y+ +V+ +P+ E IY+++F+ +CEE+RQ E + + L FS
Sbjct: 265 ILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESR--IVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFMDEWQWKPS--DLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRL--------------------QMHHVAQVLRELLGDFTQPLYPRPRHN-DRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAE---EYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM-LAF----PLLLTGL----------------------------ISFREKRLQDVGTPAARARAFFTAPVVV-FHLNILSYFAFLCLFAYVLMVDFQPVPS-------WCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFS 865
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Match: sp|Q9BX84|TRPM6_HUMAN (Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens OX=9606 GN=TRPM6 PE=1 SV=2) HSP 1 Score: 158.303 bits (399), Expect = 4.266e-37 Identity = 164/683 (24.01%), Postives = 308/683 (45.10%), Query Frame = 2
Query: 1508 TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME------LPNSKHKENISALVN--------ENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDIL--YIIGKV-----VQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNND--ETSFNEDFYEENGLLSLNAQ---------------------NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-----SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMD-------SSEMKLLEKTEEVQYSYPVKRIESEK---------------ISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
TL+ +H +F+ DDGT +Y E++ R E YL +++ +V ++ EGG + V+ + D+ P+V+ +G+G A+L+A + + + KE I ++ +++HLF+ I C ++R I I+D + + D IL A++ G N S + L L + + IA + + ++ K +E+ + L +R +F++L IE + +F+ L +LY P L+ ++ + T + ID+ ++ Y+IG+ +K + NLY KYK + AE L++ T+ F E++ +L + + +L +WA+L +M++ FW+ ++ A++A + R+MA S M+ ++ ++ SK++ L++ +L +A+K+N+ LL EL+ W+N+TCL++A + + F++H+ + +T +WMG L ++W KII++ I + P I+ F K M D S + K Y ++R EK + + + FY A IVKF+ Y ++Y++FL++F Y LVE++P V+ E + IY+FT E +R+
Sbjct: 240 TLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQ---------ILMECMVHRDC---ITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPD--ALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDV---KQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMV----DDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIIS-----IILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQ-------EWLVSIYIFTNAIEVVRE 889
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Match: sp|Q7TN37|TRPM4_MOUSE (Transient receptor potential cation channel subfamily M member 4 OS=Mus musculus OX=10090 GN=Trpm4 PE=1 SV=1) HSP 1 Score: 152.525 bits (384), Expect = 2.033e-35 Identity = 153/649 (23.57%), Postives = 287/649 (44.22%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-KNKT-------DAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME---LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQ--IVIYDMMNNNMKFDKKILEAMILGYNNS-----LDKTLKLCIRFKCPKIANRAVF-SDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNV------IKNLYEKY--KFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIE-SEKIS-----------------YREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
LD + F DDGT + E FRL+FE+Y+ + KT D ++ +L +G ++ + ++P ++V GSGG A+ + +E P S A + + F K E+ + ++ R R+ + +Y + + +F+ +L A++ +S LD+ L+L + + IA +F D +++ +E ++ L +RPEF+ L I + + F+ L LY + +P+ L+ L A +K +++ +G+V++ L G +N + Y + E + L+++ A Q + D SF + + +L +WALL +M++ FW+ + + SAL A +LR MA L + + K + T ++ +SV + E Y ++ + LL+R W TCLQ+A +D F +S +T+ W GE+ W ++L F PLI I+ +S++ + + + + + P +E S K++ + + F+GA + F ++SY+ FLL+F ++ LV+ +P K ++E+ +Y + FT +CEE+RQ L
Sbjct: 226 LDYNYSAFFLVDDGTYGRLGGENRFRLRFESYVAQQKTGVGGTGIDIPVLLLLIDGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEAR-DRIRRYFPKGDPEVLQ-----AQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEASAYLDE-LRLAVAWNRVDIAQSELFRGDIQWRSFH---LEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYS-AVSPNS-----LIRNLLDQASHASSSKSPPVNGTVELRPPNVGQVLRTLLGETCAPRYPARNTRDSYLGQDHRENDSLLMDWANKQPSTD-ASFEQAPWS----------DLLIWALLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLESEAEEAARRKDLAAT---FESMSVDLFGECYHNSEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDSTTPIWALLLA-----FFCPPLIYTNL----IVFRKSEEEPTQKDLDFDMDSSINGAGPPGTVEPSAKVALERRQRRRPGRALCCGKFSKRWSDFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQP------TKPSVSELLLYFWAFTLLCEELRQGL 829
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Match: A0A077LAN8 (Transient receptor potential ion channel M b (Fragment) OS=Dugesia japonica OX=6161 GN=DjTRPMb PE=2 SV=1) HSP 1 Score: 233.802 bits (595), Expect = 1.448e-59 Identity = 186/716 (25.98%), Postives = 336/716 (46.93%), Query Frame = 2
Query: 1493 EKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENI----SALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGY----NNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEK----NKLILNDAEIQLNND---ETSFNEDFYE---------------------ENG---------------LLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIP--TFPPKK------IMHEE----SDKMDSSEMKL-----------------------------------LEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVS 3346
+KG+ L+ HD F+ DDGT+K++ +E+EFR +FE ++ +VQ++ EGG+ + L+ IP+V++KGS A++I V+E + E I S V+E + K + + + Y+ +Q+ +++M + D I+EA G N D LKL + F +A +F D I+ + K L N+ +F++ F+ VE F+ ++L DLY F+ E + +A + N N ++ L +GK++ +L+ N+ +Y + + + N + + D ++ ++N E +E + E +NG + Q+LFLWALL+ EM+ +FWK KD IGSAL+AS I S+ +G+ ++ + + ++ +S+ IL+EAY++++++T++LLIR L W +CL IA + M+ FL HSAC++ + +W+G++ I++N++I++ IPF F+ + I P F K+ ++EE S+K S E + L++TE + + +KI + A++ FY A + KF + ++SY++FL IF Y L+EL + + + E +Y+Y +++ EIRQF N++
Sbjct: 75 KKGQSQLNPHHDAFILYDDGTDKKFGQEIEFRAQFEEFISKTAKCSVVQLIVEGGKNTIRTGAEALDSNIPVVVMKGSRRAADVICDVVEASDDMLDETIELKYSEFVDEWNMKSKDDKANFQQNLRNFAKRYKDKHKQVHLFNMRDFKNNLDTAIIEAAFSGTIDDKNLGDDAKLKLAMTFNRADVAEERIFEDKT--DINLRLYMKQ---ALVRNQWQFVDFFLRQGITVESFLTKKLLHDLY---FDK------EAIGYFIPAALLIF---GNMNSKEIQNLKTVGKIISRLTSNIFPAMYREAEPDSCSCCCWNNVKITDTQLSIDNSTDYEVKDHEKYIEPKVITESSNCCHVKRDGNSNGDNGNRIKYTIHPTRNREKEIIYTEQDLFLWALLTQRIEMAKIFWKNGKDHIGSALVASLICNSLQKKAGAKGEIEIQNNLKKFQEDFETMSIDILSEAYRRDQIRTHLLLIRGLPYWGRESCLDIANKNQMINFLFHSACQTRLNHIWLGKIPNIVNNFQILVNIPFGFLTSRLFIFPYNLFGKKQNDSANEKLNEEQQSISNKFQSPESEFNISKQTSSDNFFQNDYQIVNLKSKNWKKNKKSQEELKRTEYLSKFRKEEHFSMDKIHFCSAVKYFYTAPVTKFVMNIISYLAFLTIFSYFLLIELNIMSLSPNPINRATEYSVYVYFISYVIGEIRQFFMGGQANNLA 773
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Match: A0A4W3H5R4 (Uncharacterized protein OS=Callorhinchus milii OX=7868 PE=4 SV=1) HSP 1 Score: 220.32 bits (560), Expect = 9.061e-54 Identity = 174/650 (26.77%), Postives = 315/650 (48.46%), Query Frame = 2
Query: 1490 NEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNK--------TDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSK-----HKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNS-------LDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLD---ILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
N+ LD H +F+ DDGT +Y E+ R E Y+ + + ++ ++ EGG + +++ + + +P VIV+GSG A+++ASV LP S+ ++ + +E + F S I + + +I R ++ V N + D IL+A++ +N+ L+ LKL + + IA +F+D K K S + + L N+P F+ELF+EN + +F+ EIL LY N Q + LL + R A + + +D +L+ + ++++L G+ + YEK K K L L ++ Q E+ +D +E A++LFLWA+L ++ + W + D I SAL+A+ IL+ ++S + D +L + E +++Y+D ++ + TE Y+K+ + LLIR W NTTCL++A D F+ +S++TK+W G++S W+++L + ++ P I+H E ++K +V S + + + + +S E +R FY A +V FY +L+Y FL +F Y+ L++ + + E ++Y+++FT +CEEIRQ + + + +L FS
Sbjct: 232 NQGRLSCLDHNHSHFILVDDGTHGKYGVEILLRSNLEKYISKQRMGTEDVGIETPIICVVLEGGEGTLNTIHSAMMNGMPCVIVEGSGRAADVLASVANLPVSQITISLMQKQLRTFFSETFNTF--SDRRIISWTKKVQDIVRMHQLLTVFKAEKARNQELDVAILQALLKASSNASHLGKENLEHQLKLAVAWDRVDIAKSEIFTDKKRWKSS--NLHQAMFAALVGNKPGFVELFLENGVNLGEFVTPEILERLYN---NVPQ---STLLYKKLRKAVEGERRRDASDNVDAKQRILLHHVSGILRELLGDFTEPFYEKPKDHQCKKHLKLKHSDSQ----ESEICDDVEQE---FEEPARDLFLWAILQKRKMLANILWVQSSDSIASALVATKILKKLSS---EANDTDLSEAMEELAQEYEDRAIGVFTECYRKDPKRAQKLLIRVSNAWGNTTCLRLAIEGDDQNFMAQGGVQSFLTKIWWGDISVDTQTWQVLLCM---------VLWP------IIHSNFISFRQDEEIRMKKASKVDSSSDISQKDLKPLSCCERLRAFYTAPVVVFYWNVLAYFGFLWLFSYVLLIDFQSQPSGR-------EYFLYLWLFTLVCEEIRQLFSNPDDLGFWKKAILYFS 839
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Match: L8Y5K9 (Transient receptor potential cation channel subfamily M member 2 OS=Tupaia chinensis OX=246437 GN=TREES_T100005981 PE=4 SV=1) HSP 1 Score: 205.297 bits (521), Expect = 4.208e-49 Identity = 162/641 (25.27%), Postives = 311/641 (48.52%), Query Frame = 2
Query: 1484 LINEKGKHTL---DGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTD--------AFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILT-IPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
+++E+G+ +L D H +F+ DDGT QY E+ R K E ++ +T +V ++ EGG + +Y + P VIV+GSG +A++IA V LP S E +L+ + Q +FE ++G I E+ + +I R+ + + + + D IL+A++ G+ N D LKL + + IA +F+D K S + M I L N+PEF++LF+EN ++ +F+ + L LY+ + P C L ++ + + + + +V+++L G+ + LY + + S ++++ +L ++LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + D + ++ + +Y+ ++ + TE Y+K++ + LL+R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++IL + F +F + +F H L + + +Q + RI + F+ A +V F++ +LSY SFL +F Y+ +V+ +P +E IY+++F+ +CEE RQ
Sbjct: 183 ILDEEGQGSLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKVPIVCVVLEGGPGTLHTIYNAITKGTPCVIVEGSGRVADVIAQVANLPIS---EITISLIQQKLSIFFQEMFETFTEGRIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSQDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDEWQWKPS--DLYPMMIAALISNKPEFVKLFLENGVQLTEFVTWDTLLYLYE-NLEPS-CLFHSKLQKVLVEEPERLACAPTAPRVQM---HHVAQVLRELLGDFTQPLYPRPRHS-DRSRALLPVPHLKLNMQGVSLRSLYKRSSGYVAFTMDPVRDLLIWAVVQNRRELAEIIWAQSRDCIAAALACSKILKELSK---EEQDTDSSEEMLALADEYEHRAIGVFTECYRKDEERAQKLLVRVSEAWGRTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVILCMLAFPLLFTS---LVSFSTGDHCH---------AFVLCCRDKRLQAMCGLARICA-----------FFNAPVVIFHLNILSYFSFLCLFAYVLMVDFQPTPS-------WSECAIYLWLFSLVCEETRQLF 778
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Match: G1PHK5 (Transient receptor potential cation channel subfamily M member 2 OS=Myotis lucifugus OX=59463 GN=TRPM2 PE=4 SV=1) HSP 1 Score: 204.527 bits (519), Expect = 7.981e-49 Identity = 168/665 (25.26%), Postives = 321/665 (48.27%), Query Frame = 2
Query: 1484 LINEKGKH---TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPD---QCQCAELLSE-----LCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E+G+ LD H +F+ DDGT +Y E+ R K E ++ +T +V ++ EGG + +Y + P V+V+GSG +A++IA V LP S E AL+ + Q +FE ++G I E+ + +I R+ + + + + D IL+A++ G+ N D LKL + + IA +F+D + K S + M L N+PEF++LF+EN +++F+ + L LY+ + +P C+ ++L+E C A + ++ + +V+++L G+ + LY + + S+++ +L+L I+LN S + +G ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + ++ + +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++IL + +F + +I S+ +R+++ + R +R F+ A +V F++ +LSY SFL +F Y+ +V+ +P E IY+++F+ +CEE+RQ L E + LL FS
Sbjct: 264 IMDEEGQGHLTCLDSNHSHFILVDDGTHGRYGVEIPLRSKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAITHGTPCVVVEGSGRVADVIAQVAGLPIS---EITIALIQQKLAVFFQEMFETFTEGTIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSHDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDERQWKPSE--LHPMMTAALISNKPEFVKLFLENGLRLKEFVTWDTLLYLYK-NLDPSCLFHCKLQKVLAEEPEHVACAPA------------LPAVQMHHVAQVLRELLGDSTQLLYPRPR-SSDRPRLLLPVPHIKLNVQGVSLRSLYKRSSGQVAFTMDPVRDLLIWAIVQNRRELAEIIWAQSQDCIAAALACSKILKELSKEEED---TDSSEEMLALADQYELRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVILCM-LAFPLLTTGLI--------------------------------SFRDRRLQAVRGLAR--VRAFFNAPVVIFHLNILSYFSFLCLFAYVLMVDFQP-------SPSWCERLIYLWLFSLVCEELRQLLYDPDECGLVKMALLYFS 863
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Match: L5M6D4 (Transient receptor potential cation channel subfamily M member 2 OS=Myotis davidii OX=225400 GN=MDA_GLEAN10004975 PE=4 SV=1) HSP 1 Score: 202.986 bits (515), Expect = 2.195e-48 Identity = 165/660 (25.00%), Postives = 319/660 (48.33%), Query Frame = 2
Query: 1484 LINEKGKH---TLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN-----QHLFEK-SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMI--------LGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPD---QCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLN---AQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEMLL*FS 3370
+++E+G+ LD H +F+ DDGT +Y E+ R K E ++ +T +V ++ EGG + +Y + P V+V+GSG +A++IA V LP S E AL+ + Q +FE ++G I E+ + +I R+++ + + + D IL+A++ G+ N D LKL + + IA +F+D + K S + M L N+PEF++LF+EN +++F+ + L LY+ + +P C+ ++L+E + ++ + +V+++L G+ + LY + + S+++ +L+L I+LN S + + ++ ++L +WA++ E++ + W ++D I +AL S IL+ ++ + ++ + +Y+ ++ + TE Y+K++ + LL R + W TTCLQ+A + ++F++H ++++TKVW G+LS W++IL + +F + +I S+ +R+++ + R +R F+ A +V F++ +LSY SFL +F Y+ +V+ +P E IY+++F+ +CEE+RQ L E + LL FS
Sbjct: 242 IMDEEGQGHLTCLDSNHSHFILVDDGTHGRYGVEIPLRSKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAITHGTPCVVVEGSGRVADVIAQVAGLPIS---EITIALIQQKLAVFFQEMFETFTEGMIVEWTKKIQDIVRRWQLLTIFREGKDGQQDVDVAILQALLKASRSHDHFGHEN-WDHQLKLAVAWNRVDIARSEIFTDERQWKPSE--LHPMMTAALISNKPEFVKLFLENGLRLKEFVTWDTLLYLYK-NLDPSCLFHCKLQKVLAEEPERVACAPALPAVQ-------MHHVAQVLRELLGDSTQLLYPRPR-SSDRPRLLLPVPHIKLNVQGVSLRSLYKRSSSQVAFTMDPVRDLLIWAIVQNRRELAEIIWAQSQDCIAAALACSKILKELSKEEED---TDSSEEMLALADQYELRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVILCM-LAFPLLTTGLI--------------------------------SFRDRRLQAVRGLAR--VRAFFNAPVVIFHLNILSYFSFLCLFAYVLMVDFQP-------SPSWCERLIYLWLFSLVCEELRQLLYDPDECGLVKMALLYFS 841
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Match: trpm3 (transient receptor potential cation channel, subfamily M, member 3 [Source:ZFIN;Acc:ZDB-GENE-060531-95]) HSP 1 Score: 147.132 bits (370), Expect = 1.101e-34 Identity = 166/676 (24.56%), Postives = 301/676 (44.53%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLND--EIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN---------QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMN-NNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLI---LNDAEIQLNNDETS--------FNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSE----TSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPIL-SNWKIILTIPFSFIFIKPLI--------IPTFPPKKIMHEESDKMD--------------------SSEMKLLEKTEEVQYSY---PVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
L+ LH +F+ D+GT +Y EV+ R + E ++ + +V ++ EGG + V L D +P+V+ GSG ++++A K+ E L+NE+ Q F S+ + L E +K K I ++ M + + D IL A++ G N S L L + + IA +F + + ++E+ ++ L +R +F++L IEN + +F+ L +LY P L+ ++ +S T Y + + ++ I G V++ L G + Y + +F T + L +D I+ +T+ + D E N S L +WA+L +M+L FW+ ++ + AL+A + ++MA + +N++ + S+ S+++ L+V +L ++YK+++ LL ELK W+N TCLQ+A + +F+ H+ + +T +WMG L S K+IL + + +P + ++SD+ D SSE + EEVQ+ + PV R E FY A IVKF+ + ++YV +L++F Y+ LV++ + E + Y+FT E++R+ L +EP
Sbjct: 133 LNSLHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAF-----GHKYSEE-GGLINESLRDQLLVTIQKTFTYSRTQAQHLFIILMECMKK-KELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVG--SLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTLSRLEELYNTRHGPSNT-LYHLVRDVKKSEETLYLQGNLPPDYRISLIDI-GLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDMPIRRGRQKTTRKREEEVDIDLDDPEINHF-SFPFHELMVWAVLLKRQKMALFFWQHGEEAMAKALVACKLCKAMAH---EASENDMVEDISQELNHNSREFGQLAVELLDQSYKQDEQMAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGLLLPPSILSLEFKNKDEMSYMPQEQEAYLQEKDSDEADKPAKDKDEEDMEFTAMLGNVSSEASRKKVVEEVQHRHRLIPVGRKIYE----------FYNAPIVKFWFHTMAYVGYLMLFNYIVLVKM-------DLWPSPQEWIVIAYIFTNGIEKMREIL--MSEPG 774
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Match: hrc (transient receptor potential cation channel subfamily M member 4-like [Source:NCBI gene;Acc:103047479]) HSP 1 Score: 133.265 bits (334), Expect = 1.469e-30 Identity = 158/670 (23.58%), Postives = 296/670 (44.18%), Query Frame = 2
Query: 1490 NEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNK---------TDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME-------LPNSKHKENI--SALVNENQHLFEK------SKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMI------LGYNNSLD-KTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAEL---LSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYE---KYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFS--ETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLE--------------------KTEEVQYSY---PVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIR 3310
+ + LD H FL DDG+ + E FR ENY+ + D ++ L G +E + L IP +++ GSGG+A+L+ V+E LP + + +N + + EK S+ ++ + ++ L ++ K + I IY + + FD +L+A++ L + SL + LKL + + IA +F+ K +++E + L ++P+F+ LFIEN V++++ L +LY+ S + L LSE A T + + LY + ++++ L G+V + Y+ K + T + K I T E Y + + +LF WA+L +EM++ FW++ + + SAL A +LR + L +N E K S E + K+++L+ + ++ Y+ ++ ++++LL ++ W TCLQ+A +D F +H ++ ++++W G++ NWK++LT +FI PL + + + E D K + K EE++++ P K+ ++ + F+ A + F L + + + L + V L + E+ +Y +VFT +CEEIR
Sbjct: 233 TSRDSYCLDTNHQAFLLVDDGSTGRRGGEARFRAGLENYISQQRTGKLGSGSMDIPVLCTLVSGELYMLERLDLSLKKCIPWMVLAGSGGLADLVTDVLENVAAAPVLPAGGAEGEGEATTKINLRERVAEKVVKHFPSEPDVDKLVDKLLNVH-KSQDLISIYHLEQEGPEDFDTVLLKALVRASKQRLSSDASLSTEELKLAVTWNRVDIARSELFTGDIQWK--NESLESFMTDALVNDKPQFVRLFIENGLNVQEYMTFGRLEELYR-SISDSSVAYTLLQRHLSERQGVAGTGWPAADPAKGL---TLYEVAQLLEDLLGDVCQPFYDDKLKIQGITSRRKTI--------KKLTTVLQEGEYRQQRCV-FPWASLFTWAVLQNRSEMAVFFWEMTPESVLSALSACKLLRELCKL-----ENETETKHSLKELAMKFENLAHDVFSKCYQSSESRSFVLLKKKSVVWRGATCLQMAMEADARHFFSHDGVQTLLSQIWWGDMDRNTENWKLVLT-----LFIPPLCYTSLISFREVEEAEDGTPEEAPKARDIDWLYAETVFSFADIKRIQTKQEELRFTPKGNPTKKSPQKQCFLLSRWKQFWYAPVTAF---LGNMLMYFLFLLLFAYVLLVDFKPPPPKGPSPMELLLYFWVFTIVCEEIR 873
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Match: trpm7 (transient receptor potential cation channel subfamily M member 7 [Source:NCBI gene;Acc:111197571]) HSP 1 Score: 131.724 bits (330), Expect = 6.130e-30 Identity = 156/689 (22.64%), Postives = 298/689 (43.25%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLNDE--IPIVIVKGSGGIANLIASVME-------LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAE-------------------IQLNNDETSFNEDFYE-------------------------ENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGD--NNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMDSSEMKL------LEKTEEVQYS-YPVKRI--------------ESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
L+ LH +F+ D+GT +Y EV R E ++ + +V ++FEGG + V L + +P+V+ +G+G A++++ V + LP+ + I+ + + F S+ + L E + + V + ++ D IL+A++ G + S L L + + IA VF QK+ ++E+ ++ L +R +F++L IEN + +F+ L +LY +P +L+ ++ K+ + I I +G V++ L G + Y + +F N L N+ IQ + E + + F + E L +WA+L +MSL FW+ ++ + AL+A + RSM K+ D ++ ++ E S ++ L+V +L ++++++++ + LL ELK W+N+TCL++A +S + F+ H+ + ++ +WM L+ ++W K+IL+ I + P I+ + K M D+ +M + L+ +++Q + RI S ++ FY A IVKF+ L Y+ FL+++ Y+ LV+L I E + +Y+FT E+IR+
Sbjct: 216 LNNLHSHFILVDNGTVGKYGAEVNLRRDLEKHINLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILSFVHKQTEDDGGLPDGVETDIIATV----KKTFNLSQNDAVHLFQTLMECMKNKELITVFHVGSEDHQDIDVAILKALLKGTDASAFDQLVLTLAWDRVDIAKDHVFVYG--QKLLVDSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELYNTKQSPTNPNLFQLVRDV----------KQGNLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNNRRSGRAPSSGPPLRKNHEPFSIQADKKEKTRHNHFIKTAQPYKPKVEKQKRSREEVVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACKLCRSMC-YEAKKSDVVDDTSEELKEYSNEFGTLAVDLLEQSFRQDELMSMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMERLNMRKNSWYKVILS-----ILVPPAILALEYKSKAEMAHIPQSQDAHQMTMEDSEHNLQNPDDIQMDVFKETRINDHVEVKHETEVVTRSRRLPIMRKFHAFYHAPIVKFWTNTLFYLVFLMLYSYVVLVKL-------PIFPSPQEWAVILYIFTSAIEKIREMF 875
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Match: trpm7 (transient receptor potential cation channel subfamily M member 7 [Source:NCBI gene;Acc:111197571]) HSP 1 Score: 129.413 bits (324), Expect = 3.500e-29 Identity = 156/694 (22.48%), Postives = 298/694 (42.94%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLNDE--IPIVIVKGSGGIANLIASVME-------LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAE-------------------IQLNNDETSFNEDFYE------------------------------ENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGD--NNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMDSSEMKL------LEKTEEVQYS-YPVKRI--------------ESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
L+ LH +F+ D+GT +Y EV R E ++ + +V ++FEGG + V L + +P+V+ +G+G A++++ V + LP+ + I+ + + F S+ + L E + + V + ++ D IL+A++ G + S L L + + IA VF QK+ ++E+ ++ L +R +F++L IEN + +F+ L +LY +P +L+ ++ K+ + I I +G V++ L G + Y + +F N L N+ IQ + E + + F + E L +WA+L +MSL FW+ ++ + AL+A + RSM K+ D ++ ++ E S ++ L+V +L ++++++++ + LL ELK W+N+TCL++A +S + F+ H+ + ++ +WM L+ ++W K+IL+ I + P I+ + K M D+ +M + L+ +++Q + RI S ++ FY A IVKF+ L Y+ FL+++ Y+ LV+L I E + +Y+FT E+IR+
Sbjct: 237 LNNLHSHFILVDNGTVGKYGAEVNLRRDLEKHINLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILSFVHKQTEDDGGLPDGVETDIIATV----KKTFNLSQNDAVHLFQTLMECMKNKELITVFHVGSEDHQDIDVAILKALLKGTDASAFDQLVLTLAWDRVDIAKDHVFVYG--QKLLVDSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELYNTKQSPTNPNLFQLVRDV----------KQGNLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNNRRSGRAPSSGPPLRKNHEPFSIQADKKEKTRHNHFIKTAQPYKPKLESSSDLQQKRSREEVVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACKLCRSMC-YEAKKSDVVDDTSEELKEYSNEFGTLAVDLLEQSFRQDELMSMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMERLNMRKNSWYKVILS-----ILVPPAILALEYKSKAEMAHIPQSQDAHQMTMEDSEHNLQNPDDIQMDVFKETRINDHVEVKHETEVVTRSRRLPIMRKFHAFYHAPIVKFWTNTLFYLVFLMLYSYVVLVKL-------PIFPSPQEWAVILYIFTSAIEKIREMF 901
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Match: trpm7 (transient receptor potential cation channel subfamily M member 7 [Source:NCBI gene;Acc:111197571]) HSP 1 Score: 129.028 bits (323), Expect = 3.825e-29 Identity = 156/694 (22.48%), Postives = 298/694 (42.94%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLNDE--IPIVIVKGSGGIANLIASVME-------LPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAE-------------------IQLNNDETSFNEDFYE------------------------------ENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGD--NNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMDSSEMKL------LEKTEEVQYS-YPVKRI--------------ESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
L+ LH +F+ D+GT +Y EV R E ++ + +V ++FEGG + V L + +P+V+ +G+G A++++ V + LP+ + I+ + + F S+ + L E + + V + ++ D IL+A++ G + S L L + + IA VF QK+ ++E+ ++ L +R +F++L IEN + +F+ L +LY +P +L+ ++ K+ + I I +G V++ L G + Y + +F N L N+ IQ + E + + F + E L +WA+L +MSL FW+ ++ + AL+A + RSM K+ D ++ ++ E S ++ L+V +L ++++++++ + LL ELK W+N+TCL++A +S + F+ H+ + ++ +WM L+ ++W K+IL+ I + P I+ + K M D+ +M + L+ +++Q + RI S ++ FY A IVKF+ L Y+ FL+++ Y+ LV+L I E + +Y+FT E+IR+
Sbjct: 237 LNNLHSHFILVDNGTVGKYGAEVNLRRDLEKHINLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILSFVHKQTEDDGGLPDGVETDIIATV----KKTFNLSQNDAVHLFQTLMECMKNKELITVFHVGSEDHQDIDVAILKALLKGTDASAFDQLVLTLAWDRVDIAKDHVFVYG--QKLLVDSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELYNTKQSPTNPNLFQLVRDV----------KQGNLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNNRRSGRAPSSGPPLRKNHEPFSIQADKKEKTRHNHFIKTAQPYKPKLESSSDLQQKRSREEVVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACKLCRSMC-YEAKKSDVVDDTSEELKEYSNEFGTLAVDLLEQSFRQDELMSMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMERLNMRKNSWYKVILS-----ILVPPAILALEYKSKAEMAHIPQSQDAHQMTMEDSEHNLQNPDDIQMDVFKETRINDHVEVKHETEVVTRSRRLPIMRKFHAFYHAPIVKFWTNTLFYLVFLMLYSYVVLVKLP-------IFPSPQEWAVILYIFTSAIEKIREMF 901
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Sea Lamprey
Match: trpm7 (transient receptor potential cation channel, subfamily M, member 7 [Source:ZFIN;Acc:ZDB-GENE-021115-2]) HSP 1 Score: 140.198 bits (352), Expect = 1.707e-33 Identity = 161/694 (23.20%), Postives = 299/694 (43.08%), Query Frame = 2
Query: 1523 HDNFLFCDDGTEKQYDREVEFRLKFENYLKN-------KTDAFLVQILFEGGRMAMEHVYTVLNDE--IPIVIVKGSGGIANLIA-------SVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQ--KISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGN-----VIKNLYEKYKFS---TEKNKLILNDAE---IQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLE-KKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQY--------------SYPVKRIESEKISYRE---AMRV----------------------------------------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPN 3340
H +F+ DDGT +Y E + R + E ++ +V ++ EGG + V L +E +P+V+ +G+G A+++A EL + H E +V + F S G+ + L E R+ + V + ++ D IL A++ G N S L L + + IA VF ++ ++ + ++ L +R +F++L IEN + KF+ L +LY S D Q + L L R + K ++ L I +++G + + + NLY +++ S T + K ++ A + L+ + + Y N LL+ WA+L M++ FW+ ++ + AL+A + RS+A + ++ L+ K+ K+ L++ +L +++++++ LL EL+ W+N TCL++A +S F+ H+ + + +WMG L+ ++W K+IL+I PP +M E K +EM + ++EE+ P++R S ++ R A+R+ FY A IVKF+ L+Y+ FL++F Y+ LV+L+ L V+ E ++ +Y+F E +R+ +EP
Sbjct: 138 HSHFILVDDGTVGKYGAEAQLRRELEKHIATVACRAGMGQGVPVVGLVAEGGPNVIVTVLEYLLEEPPVPVVVCEGTGRAADILAFLHKNTDDTGELCDGLHDE----IVGTIKKTFNFSHGQAMHLLQTLLECMRRKELITVFHTGSEDHSDVDLAILTALLKGTNFSSADQLNLALAWDRVDIAKNHVFVYGQHWMVRLEWARWRRPMLDALVMDRVDFVKLLIENGVSMHKFLTITRLEELYNTS---DHHQMSNLRILLHRFSHLPPDYKITLIDVGLVIEFLMGGAFRSMYTRKRFRLLYHNLYGQHRASVDNTRQRKQKMSTASGVGVTLDGSDPECSCFAYPFNELLA--------WAVLMKRQRMAMFFWQHGEESLAKALVACKLYRSLAGEAKQSREDELKWKRLWCARVKFGQLALDLLDQSFRQDERMAMKLLTYELRNWSNFTCLKLAVSSRHRPFVAHTCTQMLLADMWMGRLNMRKNSWFKVILSI-------------LMPPSILMLEYKSK---AEMSHIPQSEELHQMGQEEREHRAAATRDIPMQRCLSRRVFLRLLSFAIRILLLRTVGNGSAADGGESGHKEEEGIWIRPSGLSLSRRIYEFYHAPIVKFWFNTLAYIGFLMLFTYVVLVKLQQLPSVQ-------EWFVILYLFMSAIERVREIF--MSEPG 791
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Sea Lamprey
Match: trpm2 (transient receptor potential cation channel, subfamily M, member 2 [Source:NCBI gene;Acc:799412]) HSP 1 Score: 117.857 bits (294), Expect = 1.533e-26 Identity = 123/469 (26.23%), Postives = 207/469 (44.14%), Query Frame = 2
Query: 1979 SLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELC-----------RSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLY--EKYKFSTEKNKLILNDAEIQLNNDETS--FNEDFYEENGLLSLNAQ-NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEP 3337
S D L+L + + IA +F+D + K +E++ L ENRPEFI LF+E+ + +++ L LY + P LL + R T K N L Y I ++++L G+ LY + +FS KL + TS F Y E L + + +LF+WA+L E++ FW KD + +AL+AS +L++M + D++ + Y+ L++ +L E YK ++++ LLIR+L W TCL +A +++ F +HS ++ +T++W G +S L W++IL I F PL+I T ++ + L T P + R F+ A I F+ ++SY FL +F Y+ +++ + D E +Y +V + I EE+RQ T+P
Sbjct: 369 SCDHQLRLALAWNRVDIATSEIFTDDR--KWQTGDLEQVMDAALLENRPEFISLFVEHGLILREYLTWARLESLYNGA--PASSLLHILLRRISEGEKSPADPHRRWISTLPMAPKRMNHFSL---YHISLLIRELLGDSTSMLYGNKMSRFS----KLSPSSKNTGSTKGGTSLEFKGQTYNEGQLYCPDPERDLFIWAVLLNRRELANFFWSQGKDCMAAALMASKLLKAMVQ---EEDDSDRTSDMLAQADNYEQLAIGLLDECYKDDELRAQKLLIRQLHSWGGATCLSMAYHANNKSFFSHSGVQALLTQIWWGGMSVDLKTWRVILCIIF------PLLIYT------------RIITFRWVLYAHT-----CTPTR------------WRNFWTAPITVFWANVVSYFIFLWLFAYVIIMDFQYTPD-------WPEYVLYAWVLSLILEELRQVF---TDP 778
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Sea Lamprey
Match: trpm7 (transient receptor potential cation channel, subfamily M, member 7 [Source:ZFIN;Acc:ZDB-GENE-021115-2]) HSP 1 Score: 105.145 bits (261), Expect = 1.028e-22 Identity = 72/280 (25.71%), Postives = 142/280 (50.71%), Query Frame = 2
Query: 2516 LFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMAS-LMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILTI--PFSFIFIK---PLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATE 3334
L WA+L M++ FW+ ++ + AL+A + RS+A + ++ + S ++ L++ +L +++++++ LL EL+ W+N TCL++A +S F+ H+ + + +WMG L+ ++W K+IL+I P S + ++ + P + +H+ + + + K EE + I +S + FY A IVKF+ L+Y+ FL++F Y+ LV+L+ L V+ E ++ +Y+F E +R+ + A E
Sbjct: 472 LLAWAVLMKRQRMAMFFWQHGEESLAKALVACKLYRSLAGEAKQSEAVEDSSEELKQYSTEFGQLALDLLDQSFRQDERMAMKLLTYELRNWSNFTCLKLAVSSRHRPFVAHTCTQMLLADMWMGRLNMRKNSWFKVILSILMPPSILMLEYKSKAEMSHIPQSEELHQMGNGSAADGGESGHKEEEGIW------IRPSGLSLSRRIYEFYHAPIVKFWFNTLAYIGFLMLFTYVVLVKLQQLPSVQ-------EWFVILYLFMSAIERVREVSDGARE 738
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Nematostella
Match: EDO30135 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1N0]) HSP 1 Score: 148.288 bits (373), Expect = 1.717e-35 Identity = 162/698 (23.21%), Postives = 322/698 (46.13%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENY-LKNKTDAF---------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIA-------------SVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNN-NMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEK--YKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQ--NLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDN---NLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYS--------YPVKRIESEK-ISYREAMRV-----------------------------------------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDV-LAEIYIYIYVFTFICEEIRQF 3316
Y P +G LD H +F DDGTE +Y E+ R + E +K KTD+ +V ++ EGG + +Y ++ ++P V++ GSG A+++ + + + ++++ + A V E +F +KG Y + + ++ K I +Y + + D IL+A++ +S L L + + +A +F++ Q+ + +T+ + L +++ EF ELF++N + +F++ +IL LY + P LL + K+ ID+D+ +G+V+++L G++ ++ Y K + F + + AE + + S + N + L ++FLWA+L E++ V W+ ++ + +AL+AS +L+ MAS + DN ++ + ++ +++ +V +L E + +N+ + LL+REL ++ T L++A +++ +F+ H++C+ +T++WMG ++ WK+++ + + + I P+I F P + HE + L +K+ +V+ PV R + EK +S E RV FY A KF ++ Y++F+ ++ Y+ L + K++ + EI +Y +VFT + EEIRQ
Sbjct: 233 YSMEPTPGHQGA-MLDPNHSHFFLVDDGTEGKYGVEIGMRSRIEEAIMKVKTDSRSEAGSIGVPVVLLVLEGGPNTVATMYELIKKKVPAVVIDGSGRAASVVGFAYNHTIKRNVDGQTINVIDPQYEDEVRAKVVE---VF-GAKGADKTY-SMIKDVLEDEK-MISVYSLDGEISQDIDLAILKALLKANRSSPVAQLNLALAWNRIDLAKSDIFTEE--QQWTTETLSAAMLTALLDDKAEFAELFLQNGLSMREFLSLDILCKLY--AEVPGNTTIKPLLQK--------EMGKRQVKTIDMDV---VGEVIEELMGDMFESYYRKDGHYFGE-----LASYAEGLVLKNRKSSKDLLANINRIDPLPTPYLDVFLWAVLCNRRELARVLWEAGREPMAAALMASRLLKRMASRAQE--DNTITDISSDLYDHARLFEERAVGVLDECFNENETLSQTLLVRELDHYSRMTALELAVSAESQDFIAHTSCQVLLTRLWMGTMAMNTRWWKVLVCL-YLPVLIFPIIY--FVPDE-QHERQAAEREHQKSLNQKSSKVKSHKEKNDAPVVPVYRSKEEKAVSNDEEARVGTENEEEDFQLEDYIPEIREDDSMEVIMRNKKLGFCDRIMHFYSAPFSKFVGNVVGYLAFIFLYAYVVLFNFPRFDPAKTLGGIHPTEIVLYFWVFTILIEEIRQL 897 HSP 2 Score: 51.6026 bits (122), Expect = 4.254e-6 Identity = 32/63 (50.79%), Postives = 47/63 (74.60%), Query Frame = 1
Query: 3373 FAIYXXXXXXXXXXXXXAMFGFTFNQIQEDSEKLWCFIRVMLVQEFYEKHILPPPLNIFYFII 3561
AIY++ TNILL+NLLIA+F +TF ++QEDS+K+W F R LVQE++ + + PPL + I+
Sbjct: 1066 LAIYMVFTNILLLNLLIAIFNYTFERVQEDSDKVWKFQRYDLVQEYHSRPVFAPPLVLLGHIL 1128
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Nematostella
Match: EDO47658 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLT7]) HSP 1 Score: 74.7146 bits (182), Expect = 3.900e-13 Identity = 64/238 (26.89%), Postives = 105/238 (44.12%), Query Frame = 2
Query: 2687 SKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGEL-SPILSNWKIILTIPFSFIFIKPLIIP-TFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYP-------------VKRIESEKISYREAMRV--------------FYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
S+++ D+++ +L E YK N + LLI W T L +A S EF+ HS C+ +T++WMG L + + K++L I F PLI F ++ M D S L + + P V +++ K S E + FY A I KF+ L+ Y+ FL++F ++ L+EL P+ ++ E + +VF+ EE+RQ
Sbjct: 592 SREFYDIALGLLDECYKANDVLAQRLLIYHPVYWGGRTSLSLAVASRHEEFVAHSCCQKKLTEIWMGALKTGYNGSLKVLLGILF-----PPLIFALEFRSREEMQRVPTTDDDSADDLPPDFDPYHHREPGSAQYNDGYLGDGVAFVKNRKSSGNEEEPIVEIRLLGLGKRIIGFYNAPITKFWSNLIVYLLFLVVFSHVILIELPPVPSIE-------EWVLIGFVFSLCAEEVRQ 817 HSP 2 Score: 72.4034 bits (176), Expect = 2.297e-12 Identity = 60/225 (26.67%), Postives = 105/225 (46.67%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDA------FLVQILFEGG----RMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMEL--PNSKHKENISALVNENQ--HLFEKSKGEITE------YINFL-CEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENR 2122
LD H +F+ D+GT+ +Y E+ FR EN + +K A +V ++ EGG R +E V +P+VI +GSG A+++A P++ ++ +V Q H EKS E + Y N L C R++ + I+ + + ++ DK IL A++ ++ L+ L L + + IA +F++ QK +E + L +R
Sbjct: 175 LDNNHSHFILVDNGTDGEYGGEISFRASLENLIASKKMAQKFHGVPVVLLVLEGGPNTIRTVLESVSRC--PAVPVVIAEGSGRAADILAFAHRFIAPSNGEMSGVADVVEHRQLLHKIEKSFAECSPEDRLSIYQNVLKCVAKREF---VTIFCVDDGGLEVDKAILRALLKSQHSQLEDQLSLALVWDRADIAKTEIFTED--QKWEVPMLETAMMEALLHDR 392
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Match: trpm2 (transient receptor potential cation channel subfamily M member 2 [Source:NCBI gene;Acc:101170060]) HSP 1 Score: 140.584 bits (353), Expect = 1.067e-32 Identity = 154/639 (24.10%), Postives = 290/639 (45.38%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNK--------TDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGE---------ITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNS----LD---KTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFI-NDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLY-----EKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEK--KFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEV----QYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
LD H +FL DDGT Y E+E R E + K +V ++ EGG + ++ + + P VI +G+G IA++IA V LP ++ L+++ L EK G+ + E+ + +I R + +++ D IL+A++ +S LD L+L + + IA +F++ S + + + L N+P+F+ L +EN + KF+ N+E L +LY+ + C L R +K + + + L + V+ L GN +++Y ++Y S E L L+ NN + + + + ++FLWA+L +++ + W+ +D I +AL A+ IL+ +A G+++ E+ + + Y++ ++ + +E Y ++ + LL+ W TT L +A ++ F+ S ++++T+VW GELS + N IL + +F PLI F H+E + ++ + + ++K + V + + + +S + + YG+ VKFY ++SY F +LNL + D + V E+ +Y++VF+ +CEE RQ
Sbjct: 242 LDKNHTHFLLVDDGTHGHYGVEIELRTCLEKCISGKQLGKKDSSVTIPVVCVVLEGGPGTLNTIFNAMKNGTPCVIFEGTGRIADVIAQVSGLP---LQQITITLIHQ---LMEKFFGQEYKKFTELSVIEWTKKIQDIVRMSHLLTIFRVTEDSHGDVDVAILKALLKASRSSETLTLDCWKTQLELAVAWNRVDIAKTEIFTEDSLW--SSADLHQAMFSALVGNKPQFVTLLLENGMSLRKFLQNEETLCNLYR-----EMPSCIFL-----RKLAKRVHSKADLVDSNNITLTHVSDEVRHLLGNATRHIYPPYVEQRYCMSAEDLSLSLSK-----NNGAPRPAGEVAQRDA-----SSDVFLWAVLQNNRDLAEIAWEQCQDSICAALAATRILKKLAG-----GESDAEEAEEMLNQASHYEEHAIGVFSECYNTDEERALKLLVHVSNFWGGTTSLWLALKAEDKRFVALSGVQAFMTRVWCGELS--VDN--HILRVLICMLFF-PLIYTGF--LAFRHDELFQKEAKKQEAMKKVKRVTGNTHGAQSLGSAPDKPLSCWDRLVSLYGSPQVKFYWNIVSY------FFFLNLFAGVLMMDFHATPSV-PELLLYVWVFSLVCEEFRQLF 833
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Match: trpm2 (transient receptor potential cation channel subfamily M member 2 [Source:NCBI gene;Acc:101170060]) HSP 1 Score: 140.584 bits (353), Expect = 1.083e-32 Identity = 154/639 (24.10%), Postives = 290/639 (45.38%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNK--------TDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGE---------ITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNS----LD---KTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFI-NDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLY-----EKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEK--KFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEV----QYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
LD H +FL DDGT Y E+E R E + K +V ++ EGG + ++ + + P VI +G+G IA++IA V LP ++ L+++ L EK G+ + E+ + +I R + +++ D IL+A++ +S LD L+L + + IA +F++ S + + + L N+P+F+ L +EN + KF+ N+E L +LY+ + C L R +K + + + L + V+ L GN +++Y ++Y S E L L+ NN + + + + ++FLWA+L +++ + W+ +D I +AL A+ IL+ +A G+++ E+ + + Y++ ++ + +E Y ++ + LL+ W TT L +A ++ F+ S ++++T+VW GELS + N IL + +F PLI F H+E + ++ + + ++K + V + + + +S + + YG+ VKFY ++SY F +LNL + D + V E+ +Y++VF+ +CEE RQ
Sbjct: 242 LDKNHTHFLLVDDGTHGHYGVEIELRTCLEKCISGKQLGKKDSSVTIPVVCVVLEGGPGTLNTIFNAMKNGTPCVIFEGTGRIADVIAQVSGLP---LQQITITLIHQ---LMEKFFGQEYKKFTELSVIEWTKKIQDIVRMSHLLTIFRVTEDSHGDVDVAILKALLKASRSSETLTLDCWKTQLELAVAWNRVDIAKTEIFTEDSLW--SSADLHQAMFSALVGNKPQFVTLLLENGMSLRKFLQNEETLCNLYR-----EMPSCIFL-----RKLAKRVHSKADLVDSNNITLTHVSDEVRHLLGNATRHIYPPYVEQRYCMSAEDLSLSLSK-----NNGAPRPAGEVAQRDA-----SSDVFLWAVLQNNRDLAEIAWEQCQDSICAALAATRILKKLAG-----GESDAEEAEEMLNQASHYEEHAIGVFSECYNTDEERALKLLVHVSNFWGGTTSLWLALKAEDKRFVALSGVQAFMTRVWCGELS--VDN--HILRVLICMLFF-PLIYTGF--LAFRHDELFQKEAKKQEAMKKVKRVTGNTHGAQSLGSAPDKPLSCWDRLVSLYGSPQVKFYWNIVSY------FFFLNLFAGVLMMDFHATPSV-PELLLYVWVFSLVCEEFRQLF 833
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Match: hrc (transient receptor potential cation channel subfamily M member 4 [Source:NCBI gene;Acc:101158642]) HSP 1 Score: 132.494 bits (332), Expect = 2.936e-30 Identity = 162/709 (22.85%), Postives = 301/709 (42.45%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHT--------------LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAF--------LVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVME--------LPNSKHKENISALVNENQHLFEKSKG------EITEYINFLCEIYRKYKRQIVIYDMMNNNMK-FDKKILEAMILGYNN--SLDKT-----LKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSE--LCRSARTTYFTKKNENEIDLD---------------ILYIIGKVVQKLSGNVIKNLY----EKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFS--ETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEE---VQYSYP-VKRIESEKISYREA-----------------------MRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
Y K LIN +G + LD + FL DDG+ + E+ FR K E+++ ++ ++ +L G ++ V L +P +++ GSGG+A ++ V+E S+ ++S +V+ + + ++ K E + + IY+ K I +Y+ + FDK +L+A++ S+D + L+L + + IA +F+ K K ++ N L ++P+F+ LF EN F + ++ + L LYQ P +LL L R T + ++++ D L+ + V+ L +V + Y E FS+ + L +L E+ + E+ +LF+WA+L EM+ FW++ + + AL +LR M+ L + E K S E ++ +++L+ I + Y ++ + + LLI++ W TTCLQ+ D F +H +S ++++W G++ WK++LT + LI +F ++ + ++ +LL+ + YSYP +K+ E++ R F+ A + F +L Y FL++F Y+ LV+ KP ++E +Y +VFT +CEEIR+
Sbjct: 208 YNKEQLINPEGSYPAKYDIRNSPKDSCCLDNNYQAFLLVDDGSVGRKGGEISFRAKLEDHISHQPTGIQESGINVPVLCMLISGDTSMLKRVEISLKKSLPWLVLAGSGGLAEFLSDVVENLSSSPVVQTPSEADGDLSPIVDLKERVADRVKKYFPNEKETDKVVELTLSIYQN-KDLITVYNGTQERLNDFDKVLLKALVRASKQRVSVDDSPYIEELRLAVTWNRVDIARSELFNGDILWK--DKDLKDSMTNALINDKPQFVRLFTENGFNIRSYLTYKKLEKLYQSV--PSGTLLYQLLERRLLIRHG-ITALSPAHDSQPDSPNQPKESNQCQPVMKVTLFEVSGVLDMLLDDVCQPFYYDVLELGHFSSRRRAL---KQAAKLLVGESKYREE------RCVYPWASLFIWAILQRRNEMATFFWEMAGESVLCALSGCKMLREMSKL-----ETETEGKLSLKEMAQSFENLAHDIFSSCYHSDENRAFTLLIKKSPVWGGTTCLQMGMGGDTRLFFSHDGVQSLLSQIWWGDMKRNTEVWKLLLTFFCPILCYTSLI--SFRGQEEQDKPEEEEGKPNEELLDSNYDYGTTVYSYPDLKQNEADGQGPTTPSTPMINDKDPPFRPPRRPFIVSRWRQFWFAPVTSFLGNVLMYFLFLVLFAYVLLVDFKPQ---PPWGPAVSEYVLYFWVFTIVCEEIRE 891
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Match: trpm3 (transient receptor potential cation channel subfamily M member 3 [Source:NCBI gene;Acc:100533512]) HSP 1 Score: 127.487 bits (319), Expect = 1.265e-28 Identity = 126/496 (25.40%), Postives = 226/496 (45.56%), Query Frame = 2
Query: 1511 LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYL-------KNKTDAFLVQILFEGGRMAMEHVYTVLND--EIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN---------QHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMN-NNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYI-IGKVVQKLSGNVIKNLYEKYKFSTEKNKLI---LNDAEIQLNNDETS--------FNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNL----EKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGEL 2893
L+ LH +F+ D+GT +Y EV R + E ++ + +V ++ EGG + V L D +P+V+ GSG ++++A K+ E ++NE+ Q F S+ + L E +K K I ++ M + + D IL A++ G N S L L + + IA +F + + ++E+ ++ L +R +F++L IEN V +F+ L +LY P + L L R KK D I I IG V++ L G + Y + +F T + L +D I+ +T+ + D E N L +WA+L +M+L FW+ ++ + AL+A + ++MA + +N++ ++ + S+++ L+V +L ++YK+++ LL ELK W+N TCLQ+A + +F+ H+ + +T +WMG L
Sbjct: 266 LNSLHSHFILADNGTTGKYGAEVRLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAF-----GHKYSEE-GGIINESLRDQLLVTIQKTFTYSRTQAQHLFIILMECMKK-KELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVG--SLEQAMLDALVLDRVDFVKLLIENGVSVHRFLTLSRLEELYNTRHGP-----SNTLYHLVRD------VKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDMPIRRGRQKTTRKREEEVDIDLDDPEINHF-PFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAH---EASENDMVDDISQELNHNSREFAQLAVELLDQSYKQDEQMAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRL 737
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Match: trpm6 (transient receptor potential cation channel subfamily M member 6 [Source:NCBI gene;Acc:101159200]) HSP 1 Score: 127.487 bits (319), Expect = 1.371e-28 Identity = 157/703 (22.33%), Postives = 303/703 (43.10%), Query Frame = 2
Query: 1481 PLINEKGKHT-LDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNK-------TDAFLVQILFEGGRMAMEHVYTVLN-----DEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEN--QHLFEKSKGEITEYINFLCEIYR--KYKRQIVIYDM-MNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAE-------------IQLNNDETSFNED--FYEEN------------------------GLLSL----NAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMA-SLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNW-KIILT--------------------IP-------FSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFL 3319
PL N K L+G H +FL DDGT +Y + R K E +++ + +V ++ EGG V+TVL+ +P+ + +GSG A+L++ + + + + + A + E+ + ++ E TE I + + +++ I I+D ++ M D IL + G S + L + + + IA + + ++ + ++EK ++ L +R F+++ I+N + F+ E L +LY Q L L A+ T L +G V++ L G ++ Y + F +++ ND ++ N+ +D F+ G SL N +LF+WA+L +M+L W+ ++ + A++ + RSMA L +N+ +KF S ++ L+V +L A+++N LL E++ W++ TCLQ+A +S F++HS ++ +T +W G L+ +++ KIIL+ +P F +K +P + H ++++ + EK S V I + + + + FY A +VKF+ + +SY+ FL++F ++ LV+ +E+ SI++ L + Y+ + E+ R+ L
Sbjct: 243 PLGNPLSKRVCLNGFHSHFLLVDDGTLGKYGCQQGLRRKLEKHIQQQKIHPRLNQRVPMVCVVVEGGPSI---VFTVLDYVSSAPPVPVFVFEGSGRAADLLSFLHK--QTANDRQLDADIIEDFLTRIGDEFGVERTEAIRLYSVLQQCMEHRESITIFDSESDDQMAPDAAILSTTLKGTKASPAEQLNMALAWDQADIAQKDILVYGQHWPVG--SLEKAMLDALVLDRVSFVKMLIDNGMTMSHFLTVERLEELYNTPLG----QTQRFLQHLVEDAKQTSLPAGYRLS-----LIDVGLVIEYLIGGAYRSTYTRKHFRAAYSRMQDNDRRWDSSGSFSKQRLGLKSNSRRNGSRQDLQFFRTAQPYKRKDQDATPGSTRDTRLSSSLGDASLQVLFNFNDLFVWAVLQQRQQMALFLWQHGEEALARAIVGCKLYRSMAFEARLSSMYDNIAEKFKADSLEFGKLAVDVLDCAFRQNGQMAMKLLTSEMEAWSHFTCLQLAVSSCHRPFVSHSCTQTLLTDLWTGPLNMRKNSFMKIILSLLLPPAILLLEFKSEAEMCHVPQTHEAMLFGLDSVKSTPVPQ-ATADLSHHDAER----GLPFYEKCLG-PLSRSVSTITVQWLPWITRIYDFYTAPVVKFWFHTMSYLCFLMLFSFVVLVK---MENRPSIQEWL----VIFYIVSTAVEKTREVL 916
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Match: SMESG000005064.1 (SMESG000005064.1) HSP 1 Score: 1244.57 bits (3219), Expect = 0.000e+0 Identity = 628/630 (99.68%), Postives = 630/630 (100.00%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEML 3358
YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKL+LNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMH+ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEML
Sbjct: 73 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLVLNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHDESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLEHATEPNVSLEML 702
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Match: SMESG000005064.1 (SMESG000005064.1) HSP 1 Score: 1214.52 bits (3141), Expect = 0.000e+0 Identity = 613/615 (99.67%), Postives = 615/615 (100.00%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKL+LNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMH+ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ
Sbjct: 422 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLVLNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHDESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 1036
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Match: SMESG000005064.1 (SMESG000005064.1) HSP 1 Score: 1213.75 bits (3139), Expect = 0.000e+0 Identity = 613/615 (99.67%), Postives = 615/615 (100.00%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKL+LNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMH+ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ
Sbjct: 460 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLVLNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHDESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 1074
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Match: SMESG000005064.1 (SMESG000005064.1) HSP 1 Score: 1211.05 bits (3132), Expect = 0.000e+0 Identity = 614/618 (99.35%), Postives = 616/618 (99.68%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQFLE 3322
YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKL+LNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMH+ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ E
Sbjct: 194 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLVLNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHDESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQLYE 811
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Match: SMESG000005064.1 (SMESG000005064.1) HSP 1 Score: 1208.74 bits (3126), Expect = 0.000e+0 Identity = 613/615 (99.67%), Postives = 615/615 (100.00%), Query Frame = 2
Query: 1469 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPXXXXXXXXXXXXXXKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLILNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHEESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 3313
YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKL+LNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMH+ESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ
Sbjct: 194 YYKSPLINEKGKHTLDGLHDNFLFCDDGTEKQYDREVEFRLKFENYLKNKTDAFLVQILFEGGRMAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNENQHLFEKSKGEITEYINFLCEIYRKYKRQIVIYDMMNNNMKFDKKILEAMILGYNNSLDKTLKLCIRFKCPKIANRAVFSDSKYQKISRKTIEKMFINCLKENRPEFIELFIENNFEVEKFINDEILRDLYQISFNPDQCQCAELLSELCRSARTTYFTKKNENEIDLDILYIIGKVVQKLSGNVIKNLYEKYKFSTEKNKLVLNDAEIQLNNDETSFNEDFYEENGLLSLNAQNLFLWALLSGMTEMSLVFWKINKDQIGSALLASTILRSMASLMLKRGDNNLEKKFSETSKKYQDLSVLILTEAYKKNKMKTYILLIRELKKWNNTTCLQIATNSDMLEFLNHSACRSYITKVWMGELSPILSNWKIILTIPFSFIFIKPLIIPTFPPKKIMHDESDKMDSSEMKLLEKTEEVQYSYPVKRIESEKISYREAMRVFYGATIVKFYIYLLSYVSFLLIFIYLNLVELKPLEDVKSIKDVLAEIYIYIYVFTFICEEIRQ 808 The following BLAST results are available for this feature:
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Transient receptor potential cation channel subfamily M member 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004958 ID=SMED30004958|Name=Transient receptor potential cation channel subfamily M member 8|organism=Schmidtea mediterranea sexual|type=transcript|length=6643bpback to top protein sequence of SMED30004958-orf-1 >SMED30004958-orf-1 ID=SMED30004958-orf-1|Name=SMED30004958-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=128bp MVKYGRESPAEVQLCLNHGLHLAVCNTFYLRKRINDNQNTSSEDEAIGNNback to top protein sequence of SMED30004958-orf-2 >SMED30004958-orf-2 ID=SMED30004958-orf-2|Name=SMED30004958-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=118bp MKRYSSSDTTDVYRLGYSQFNKRVPKLKFSFVSRLDIFFECVNFRYCFDKback to top protein sequence of SMED30004958-orf-3 >SMED30004958-orf-3 ID=SMED30004958-orf-3|Name=SMED30004958-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=119bp MTNILLVNLLIAMFGFTFNQIQEDSEKLWCFIRVMLVQEFYEKHILPPPLback to top protein sequence of SMED30004958-orf-4 >SMED30004958-orf-4 ID=SMED30004958-orf-4|Name=SMED30004958-orf-4|organism=Schmidtea mediterranea sexual|type=polypeptide|length=568bp MAMEHVYTVLNDEIPIVIVKGSGGIANLIASVMELPNSKHKENISALVNEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
