Polypyrimidine tract binding protein 1

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + E      PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + L  +  P     L   +      +             G  T  +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   39 ANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLGLPVAAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNT--VLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 533          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + L  +  P     L   +      +             G  T  +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLGLPVAAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNT--VLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRD-HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 534          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + E      PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   39 ANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDV-LHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 528          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRD-HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 529          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE-------NAVSTTN--------QICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSKQYL 1652
            PS+V+H+R LP DVTE E+ S+  PFG ++ +++ +   QA +EM T+E A TM  YY   +P LR +  +IQ+S+H  L+ TDSS +           N+V + N         +   MA     PVLR++V++  +    ++ L +IF  +G + +I+ +      Q  +QY++P SA+ AK   +G  ++  CC LR++FS   SL++   +D  RD+ R P  P          G   P   +                  AA       A   P  A+P    ++ P + G L    +     +             G   S +L+VSNLN  ++ P +LF LFG YGDV RVKI++N+K  AL+Q A    AQ A+  LNG  L+GKP+ +  SKH  +  + P  G E++     L ++Y +S LHRFK+  S+N  NI+ PS  LH++ +   VSEED++ LF+ N   VK  + F    +KMAL+++ SVE A++ALI+LH++DL G N  LRVSFSK  +
Sbjct:   57 PSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELK-TDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDV-LHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTR-PDLPS---------GDSQPSLDQTMA---------------AAFASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNS-VLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNV--QLPREGQEDQG----LTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKD-RKMALIQMGSVEEAVQALIDLHNHDL-GENHHLRVSFSKSTI 550          

Query:  108 EIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERF-RDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGF-LDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
             IP SKV+HVR++P D+ ++E+  +   +G +S  ++ +   QA +E E +  A             +R +  F QYS H  L+   +    + E+  + +    +   ++Q   VLR ++++       ++ L+++F  YG + RI+ +      Q  +Q SE  SA++AK       V+  CC LR+++S   +L++   +D  RD+  +P  P     +   I   IP        +   F    +P  T    Q   + AA    +      ++AP +    L S +L P   S      N          +P+++VSNL+E K+  DALF LFG YGDV RVKI+YN+K+ ALIQ++  + AQ AL  L+ V  + + + V  SKH  +  + P  G  +      L R+Y  S LHRFK+  S+N+ NIY P   LH++ +   VSEE ++ +F +  F VK  + F     KMAL +L  +E+AI+ALI +H++ L   ++LRVSFSK
Sbjct:  116 SIPVSKVVHVRNIPPDLVDVELMQLCIQYGPVSNYMMLKGKSQAFVEYEEEASAAAFVSGMTAVPIQIRGRTLFAQYSTHRELKFDKNKAISDTESVANGSVSNFEVGTQQQPNSVLRTIIENMMFPVSLDV-LYQLFTRYGKVLRIITFNKNNTFQALVQMSEANSAQLAKQGLENQNVYNGCCTLRIDYSKLSTLNVKYNNDKSRDYT-NPNLPAGEMTLEQTIAMSIPGLQNLIPANPYNFAFGANPATTFLTTQLAASTAAAAAVNDSANAAALAPYLNPLGLTSANLAPSISSMRFPMINL---------TPVILVSNLHEMKVTTDALFTLFGVYGDVMRVKILYNKKDNALIQYSEPQQAQLALTHLDKVKWHDRLIRVAPSKHTNV--QMPKEGQPDAG----LTRDYAHSTLHRFKKPGSKNYLNIYPPCATLHLSNIPTSVSEEKLKEMFAEAGFAVKAFKFF-PKDHKMALCQLEDIETAIDALIAMHNHKLAENAHLRVSFSK 612          

Query:  435 KEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERF-RDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGF-LDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            ++Q   VLR ++++       ++ L+++F  YG + RI+ +      Q  +Q SE  SA++AK       V+  CC LR+++S   +L++   +D  RD+  +P  P     +   I   IP        +   F    +P  T    Q   + AA    +      ++AP +    L S +L P   S      N          +P+++VSNL+E K+  DALF LFG YGDV RVKI+YN+K+ ALIQ++  + AQ AL  L+ V  + + + V  SKH  +  + P  G  +      L R+Y  S LHRFK+  S+N+ NIY P   LH++ +   VSEE ++ +F +  F VK  + F     KMAL +L  +E+AI+ALI +H++ L   ++LRVSFSK
Sbjct:   63 QQQPNSVLRTIIENMMFPVSLDV-LYQLFTRYGKVLRIITFNKNNTFQALVQMSEANSAQLAKQGLENQNVYNGCCTLRIDYSKLSTLNVKYNNDKSRDYT-NPNLPAGEMTLEQTIAMSIPGLQNLIPANPYNFAFGANPATTFLTTQLAASTAAAAAVNDSANAAALAPYLNPLGLTSANLAPSISSMRFPMINL---------TPVILVSNLHEMKVTTDALFTLFGVYGDVMRVKILYNKKDNALIQYSEPQQAQLALTHLDKVKWHDRLIRVAPSKHTNV--QMPKEGQPDAG----LTRDYAHSTLHRFKKPGSKNYLNIYPPCATLHLSNIPTSVSEEKLKEMFAEAGFAVKAFKFF-PKDHKMALCQLEDIETAIDALIAMHNHKLAENAHLRVSFSK 450          

Query:  435 KEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERF-RDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGF-LDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            ++Q   VLR ++++       ++ L+++F  YG + RI+ +      Q  +Q SE  SA++AK       V+  CC LR+++S   +L++   +D  RD+  +P  P     +   I   IP        +   F    +P  T    Q   + AA    +      ++AP +    L S +L P   S      N          +P+++VSNL+E K+  DALF LFG YGDV RVKI+YN+K+ ALIQ++  + AQ AL  L+ V  + + + V  SKH  +  + P  G  +      L R+Y  S LHRFK+  S+N+ NIY P   LH++ +   VSEE ++ +F +  F VK  + F     KMAL +L  +E+AI+ALI +H++ L   ++LRVSFSK
Sbjct:   63 QQQPNSVLRTIIENMMFPVSLDV-LYQLFTRYGKVLRIITFNKNNTFQALVQMSEANSAQLAKQGLENQNVYNGCCTLRIDYSKLSTLNVKYNNDKSRDYT-NPNLPAGEMTLEQTIAMSIPGLQNLIPANPYNFAFGANPATTFLTTQLAASTAAAAAVNDSANAAALAPYLNPLGLTSANLAPSISSMRFPMINL---------TPVILVSNLHEMKVTTDALFTLFGVYGDVMRVKILYNKKDNALIQYSEPQQAQLALTHLDKVKWHDRLIRVAPSKHTNV--QMPKEGQPDAG----LTRDYAHSTLHRFKKPGSKNYLNIYPPCATLHLSNIPTSVSEEKLKEMFAEAGFAVKAFKFF-PKDHKMALCQLEDIETAIDALIAMHNHKLAENAHLRVSFSK 450          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLH-LFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLR--SIAPAIRGFLD--------------SQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISH-RAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLH---VAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMA--LVELSSVESAIEAL 1586
            PS V+HVR+L   VTE ++    + FG ++Y      +  AL+E E  E A+    +   +  ++  +     YS                      T+Q  + M  E A P   LVV   N +   +   +++I    G + R+ +     +VQ  +++     AK AK   NG  ++  CC L+V F+    + + R+D   RDF                    +P + E F+D            TL   +P   +   + DD     R    AP+  G+                     P    R D  D       G     ++++  L   KI+ D LF +   YG+V R+  M  +  T +I+  T E  Q  L FL G  L+G  L    S  + + H R P    +    G    ++Y+ S+  RF   +    + I  P+  LH     G +D+ +  D+ A  T++K    KI +F S  ++ A    E  +VE A E L
Sbjct:   30 PSIVVHVRNLHQKVTEADLLEALSNFGPVAYATCIPHSRMALVEFEDIEGAKACVNFATSNQINVGGQGALFNYS----------------------TSQCIERMGFESATPNKVLVVTVLNAQYPIDADVIYQISNAQGKVLRVAVMHKPTVVQALVEFESMEVAKAAKHAMNGADIYSGCCTLKVEFAKPDRVRVQRQDKDQRDFT-------------------LP-DNESFQDTGR--------KTLIPAKPDDHYRRPYEDDRNHYDRHDYQAPSSYGYSSRGGGHSDYYGGDRGGPPHPPPSRYRDDYEDRGYAQPAGGGPGCVMMIYGLEHGKINCDMLFNILCQYGNVLRISFMRTKTETGIIELGTPEERQNVLDFLQGSALFGLTLEFKPSHQECVHHLRDPFLLPD----GSPSFKDYSSSRNQRFSTPELAAKNRIIFPTNTLHWFNAPGTMDEQALLDLMAEKTEHK--PVKIDIFPSRNERSAAGTAEFETVEIANEVL 486          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLH-LFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLR--SIAPAIRGFLD--------------SQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISH-RAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLH---VAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMA--LVELSSVESAIEAL 1586
            PS V+HVR+L   VTE ++    + FG ++Y      +  AL+E E  E A+    +   +  ++  +     YS                      T+Q  + M  E A P   LVV   N +   +   +++I    G + R+ +     +VQ  +++     AK AK   NG  ++  CC L+V F+    + + R+D   RDF                    +P + E F+D            TL   +P   +   + DD     R    AP+  G+                     P    R D  D       G     ++++  L   KI+ D LF +   YG+V R+  M  +  T +I+  T E  Q  L FL G  L+G  L    S  + + H R P    +    G    ++Y+ S+  RF   +    + I  P+  LH     G +D+ +  D+ A  T++K    KI +F S  ++ A    E  +VE A E L
Sbjct:   30 PSIVVHVRNLHQKVTEADLLEALSNFGPVAYATCIPHSRMALVEFEDIEGAKACVNFATSNQINVGGQGALFNYS----------------------TSQCIERMGFESATPNKVLVVTVLNAQYPIDADVIYQISNAQGKVLRVAVMHKPTVVQALVEFESMEVAKAAKHAMNGADIYSGCCTLKVEFAKPDRVRVQRQDKDQRDFT-------------------LP-DNESFQDTGR--------KTLIPAKPDDHYRRPYEDDRNHYDRHDYQAPSSYGYSSRGGGHSDYYGGDRGGPPHPPPSRYRDDYEDRGYAQPAGGGPGCVMMIYGLEHGKINCDMLFNILCQYGNVLRISFMRTKTETGIIELGTPEERQNVLDFLQGSALFGLTLEFKPSHQECVHHLRDPFLLPD----GSPSFKDYSSSRNQRFSTPELAAKNRIIFPTNTLHWFNAPGTMDEQALLDLMAEKTEHK--PVKIDIFPSRNERSAAGTAEFETVEIANEVL 486          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQS----------TDSSMHPEAENA------------------------------VSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETE------RFRDIREFRELRDPIDTLAALQP----LLTHAATHPDDAMP-----------LLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            SKV+H+R++P++  E ++ ++  PFG ++ +++ +   QA +EM  +  A +M   Y    P +R +  ++Q+S+H  L++          +D S+   A  +                               S  N   ++ A      VLR++V+   +    ++ L +IFQ YG + +IV +      Q  IQY +  SA+ AK+L +G  ++  CC LR++ S   +L++   +D  RDF    + P E     +   GG+    +      R R      ++ + +     L P    L T      ++A+P            L++ APA+RG+                             S +L+VSNLNE  + PDALF LFG YGDV RVKI+YN+K++ALIQ A  + A  A+  L+ + L+GKP+ V  SKH  +  + P  G  +      L R+Y+ + LHRFK+  S+N+ NIY PS  LH++ +    SE+DI+  FT N F VK  + F    +KMAL++L SVE A+ ALI++H++ L  SN LRVSFSK
Sbjct:   33 SKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDI-LHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY-----------------------------SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAV--QLPKEGQPDAG----LTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFF-PKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSK 565          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQS----------TDSSMHPEAENA------------------------------VSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETE------RFRDIREFRELRDPIDTLAALQP----LLTHAATHPDDAMP-----------LLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            SKV+H+R++P++  E ++ ++  PFG ++ +++ +   QA +EM  +  A +M   Y    P +R +  ++Q+S+H  L++          +D S+   A  +                               S  N   ++ A      VLR++V+   +    ++ L +IFQ YG + +IV +      Q  IQY +  SA+ AK+L +G  ++  CC LR++ S   +L++   +D  RDF    + P E     +   GG+    +      R R      ++ + +     L P    L T      ++A+P            L++ APA+RG+                             S +L+VSNLNE  + PDALF LFG YGDV RVKI+YN+K++ALIQ A  + A  A+  L+ + L+GKP+ V  SKH  +  + P  G  +      L R+Y+ + LHRFK+  S+N+ NIY PS  LH++ +    SE+DI+  FT N F VK  + F    +KMAL++L SVE A+ ALI++H++ L  SN LRVSFSK
Sbjct:   46 SKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDI-LHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY-----------------------------SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAV--QLPKEGQPDAG----LTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFF-PKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSK 578          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQS----------TDSSMHPEAENA------------------------------VSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETE------RFRDIREFRELRDPIDTLAALQP----LLTHAATHPDDAMP-----------LLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            SKV+H+R++P++  E ++ ++  PFG ++ +++ +   QA +EM  +  A +M   Y    P +R +  ++Q+S+H  L++          +D S+   A  +                               S  N   ++ A      VLR++V+   +    ++ L +IFQ YG + +IV +      Q  IQY +  SA+ AK+L +G  ++  CC LR++ S   +L++   +D  RDF    + P E     +   GG+    +      R R      ++ + +     L P    L T      ++A+P            L++ APA+RG+                             S +L+VSNLNE  + PDALF LFG YGDV RVKI+YN+K++ALIQ A  + A  A+  L+ + L+GKP+ V  SKH  +  + P  G  +      L R+Y+ + LHRFK+  S+N+ NIY PS  LH++ +    SE+DI+  FT N F VK  + F    +KMAL++L SVE A+ ALI++H++ L  SN LRVSFSK
Sbjct:   46 SKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDI-LHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY-----------------------------SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAV--QLPKEGQPDAG----LTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFF-PKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSK 578          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQS----------TDSSMHPEAENA------------------------------VSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETE------RFRDIREFRELRDPIDTLAALQP----LLTHAATHPDDAMP-----------LLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            SKV+H+R++P++  E ++ ++  PFG ++ +++ +   QA +EM  +  A +M   Y    P +R +  ++Q+S+H  L++          +D S+   A  +                               S  N   ++ A      VLR++V+   +    ++ L +IFQ YG + +IV +      Q  IQY +  SA+ AK+L +G  ++  CC LR++ S   +L++   +D  RDF    + P E     +   GG+    +      R R      ++ + +     L P    L T      ++A+P            L++ APA+RG+                             S +L+VSNLNE  + PDALF LFG YGDV RVKI+YN+K++ALIQ A  + A  A+  L+ + L+GKP+ V  SKH  +  + P  G  +      L R+Y+ + LHRFK+  S+N+ NIY PS  LH++ +    SE+DI+  FT N F VK  + F    +KMAL++L SVE A+ ALI++H++ L  SN LRVSFSK
Sbjct:   46 SKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDI-LHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY-----------------------------SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAV--QLPKEGQPDAG----LTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFF-PKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSK 578          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQS----------TDSSMHPEAENA------------------------------VSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETE------RFRDIREFRELRDPIDTLAALQP----LLTHAATHPDDAMP-----------LLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            SKV+H+R++P++  E ++ ++  PFG ++ +++ +   QA +EM  +  A +M   Y    P +R +  ++Q+S+H  L++          +D S+   A  +                               S  N   ++ A      VLR++V+   +    ++ L +IFQ YG + +IV +      Q  IQY +  SA+ AK+L +G  ++  CC LR++ S   +L++   +D  RDF    + P E     +   GG+    +      R R      ++ + +     L P    L T      ++A+P            L++ APA+RG+                             S +L+VSNLNE  + PDALF LFG YGDV RVKI+YN+K++ALIQ A  + A  A+  L+ + L+GKP+ V  SKH  +  + P  G  +      L R+Y+ + LHRFK+  S+N+ NIY PS  LH++ +    SE+DI+  FT N F VK  + F    +KMAL++L SVE A+ ALI++H++ L  SN LRVSFSK
Sbjct:   46 SKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDI-LHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSGDKIVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY-----------------------------SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAV--QLPKEGQPDAG----LTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFF-PKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSK 578          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE---NAVS--------TTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIR------GFLDSQDLLPREISRHDRNDNFGRTHFGEKTSP--LLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSKQYL 1652
            ++  ++KK+R E     PPS+V+H+R LP++V+E E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +P +RN   FIQYS+H  L+ TDS+++  A+    AVS        +++    S+      PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +Q+S+P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                 P+D         + AA    D+  LL + +  +       GF  S   +    +        GR      + P  +L+VSNLN+  + P +LF LFG YGDV RVKI+YN+K++ALIQ +    AQ A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++  S LHRFK+  S+N  NI+ PS  LH++ + D+V+EED+  LF+++   VK  + F    +KM+L+++++ E AI+ALI+LH+YD+  G  LRVSFSK  +
Sbjct:   34 ANGSDSKKLRVEDSMDSPPSRVIHIRKLPNEVSETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELK-TDSALNQRAQAVLQAVSAVQEGGSPSSDMASKSVLTPAPSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------PVDP--------SMAAALSKDSPSLLGTPSGMVTSYSSGGGFPSSLGAISPLSAAAAAAAAAGRVALSGHSVPGGVLLVSNLNDEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMSDGNQAQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFTSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPDNVTEEDLRLLFSNSGGTVKAFKFFQD--RKMSLLQMATAEEAIQALIDLHNYDMGRGHRLRVSFSKSTI 538          

Query:   99 IRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQI---------CDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            IR    PS+V+HVR LP+D+ E E+ ++  PFG ++ +++ +   QA LEM ++E A+TM  YY   +P +RN   F+QYS+H  L++ +S     A+ A+   N +          D        PVLR++V++  +    ++ L +IF  +G + +++ +      Q  +Q+++  +A+ AK   +G  ++  CC LR++FS   SL++   +D  RD+ R                  +P    +                + +  P  +  A  P  A+       P + G L S  + P   +        G       T  +++VSNLN  ++ P  LF LFG YGDV RVKIM+N+K  ALIQ +    AQ A+  LNG  LYG+PL +  SKH  +  + P  G E++     L ++Y++S LHRFK+  S+N+SNI+ PS  LH++ +   V E+D++ LF  +   VK  + F    +KMAL+++SSVE AIE+LI+ H++DL G N  LRVSFSK
Sbjct:   63 IRSPAVPSRVIHVRKLPNDINEAEVIALGLPFGKVTNLLMLKGKNQAFLEMNSEEAAQTMVTYYSSVTPVIRNHPIFMQYSNHKELKTDNSPNQVRAQAALQAVNAVQTGSLTLGGVDPSGMTGPSPVLRVIVENLFYPVTLDV-LHQIFSKFGTVLKVITFTKNNQFQALLQFTDGLTAQHAKLALDGQNIYNGCCTLRISFSKLTSLNVKYNNDKSRDYTRP----------------DLPTGDSQPALEHHAVAAAFAAPGIISAAPYASAHAFPPAFAIQQAGLTIPGVPGALASLTI-PGAAAAAAAASRLGFPTL-TGTHCVMLVSNLNPERVTPHCLFILFGVYGDVLRVKIMFNKKENALIQMSDGTQAQLAMSHLNGQKLYGRPLRITLSKHTTV--QMPREGHEDQG----LTKDYSNSPLHRFKKPGSKNYSNIFPPSSTLHLSNIPPSVVEDDLKLLFGSSGALVKNFKFFQKD-RKMALIQMSSVEEAIESLIQFHNHDL-GENHHLRVSFSK 561          

Query:   99 IRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQI---------CDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            IR    PS+V+HVR LP+D+ E E+ ++  PFG ++ +++ +   QA LEM ++E A+TM  YY   +P +RN   F+QYS+H  L++ +S     A+ A+   N +          D        PVLR++V++  +    ++ L +IF  +G + +++ +      Q  +Q+++  +A+ AK   +G  ++  CC LR++FS   SL++   +D  RD+ R                  +P    +                + +  P  +  A  P  A+       P + G L S  + P   +        G       T  +++VSNLN  ++ P  LF LFG YGDV RVKIM+N+K  ALIQ +    AQ A+  LNG  LYG+PL +  SKH  +  + P  G E++     L ++Y++S LHRFK+  S+N+SNI+ PS  LH++ +   V E+D++ LF  +   VK  + F    +KMAL+++SSVE AIE+LI+ H++DL G N  LRVSFSK
Sbjct:   54 IRSPAVPSRVIHVRKLPNDINEAEVIALGLPFGKVTNLLMLKGKNQAFLEMNSEEAAQTMVTYYSSVTPVIRNHPIFMQYSNHKELKTDNSPNQVRAQAALQAVNAVQTGSLTLGGVDPSGMTGPSPVLRVIVENLFYPVTLDV-LHQIFSKFGTVLKVITFTKNNQFQALLQFTDGLTAQHAKLALDGQNIYNGCCTLRISFSKLTSLNVKYNNDKSRDYTRP----------------DLPTGDSQPALEHHAVAAAFAAPGIISAAPYASAHAFPPAFAIQQAGLTIPGVPGALASLTI-PGAAAAAAAASRLGFPTL-TGTHCVMLVSNLNPERVTPHCLFILFGVYGDVLRVKIMFNKKENALIQMSDGTQAQLAMSHLNGQKLYGRPLRITLSKHTTV--QMPREGHEDQG----LTKDYSNSPLHRFKKPGSKNYSNIFPPSSTLHLSNIPPSVVEDDLKLLFGSSGALVKNFKFFQKD-RKMALIQMSSVEEAIESLIQFHNHDL-GENHHLRVSFSK 552          

Query:   75 SDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTNQICDSMAKEQAG-------PVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRD-IREFRELRDPIDTLAALQPLLTHA-ATHPDDAMPLLRSIAP------AIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            +D+++ K  R    PS+VLHVR +P +V+E E+ S+  PFG ++ +++ +   QA +EM ++E A TM  YY   +PH+RN+  +IQYS+H  L++ +      +    +A NAV T N      A    G       PVLR++V++  +  ++   L +IF  +G + +I+ +      Q  +QY++P +A  AK   +G  ++  CC LRV FS   SL++   +D  RDF R          + +  G G P      +        +  P    A   P +    A     AMP   ++ P      A+ G +    + P  I                    +L+VSNLN   I P  LF LFG YGDV RVKI++N+K  ALIQ A    AQ A+  LNG  LYGK + V  SKH  +  + P  G E++     L ++++ S LHRFK+  S+N  NI+ PS  LH++ +    +++ ++ LF  + + VK  + F    +KMAL++L SVE AI+ALI LH++DL G N  LRVSFSK
Sbjct:    5 TDSKQYKGDRSPCAPSRVLHVRKVPIEVSEAEVVSLGVPFGKVTNLLMLKGKNQAFIEMASEEAAMTMVNYYTTATPHVRNQPVYIQYSNHRELKTDNLPNQGRAQAALQAVNAVHTGNMSLSGTATASDGGMMPGQSPVLRIIVENL-YYPVSLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNGCCTLRVEFSKLTSLNVKYNNDKSRDFTR----------LDLPSGDGQPTLDPTMQTAFGAPGIISSPYPGAAGFAPAIGFPQAGLSMQAMP--GALGPLTIPSSAMTGRMAIHGMTPTAIHS------------------VLLVSNLNPDSISPHELFILFGVYGDVHRVKILFNKKENALIQMADATQAQLAMSHLNGQRLYGKVIRVTISKHQTV--QLPREGQEDQG----LTKDFSGSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSTTDDFLKDLFASSGYTVKAFKFFQKD-RKMALIQLGSVEEAIQALIHLHNHDL-GENHHLRVSFSK 511          

Query:   75 SDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTNQICDSMAKEQAG-------PVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRD-IREFRELRDPIDTLAALQPLLTHA-ATHPDDAMPLLRSIAP------AIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            +D+++ K  R    PS+VLHVR +P +V+E E+ S+  PFG ++ +++ +   QA +EM ++E A TM  YY   +PH+RN+  +IQYS+H  L++ +      +    +A NAV T N      A    G       PVLR++V++  +  ++   L +IF  +G + +I+ +      Q  +QY++P +A  AK   +G  ++  CC LRV FS   SL++   +D  RDF R          + +  G G P      +        +  P    A   P +    A     AMP   ++ P      A+ G +    + P  I                    +L+VSNLN   I P  LF LFG YGDV RVKI++N+K  ALIQ A    AQ A+  LNG  LYGK + V  SKH  +  + P  G E++     L ++++ S LHRFK+  S+N  NI+ PS  LH++ +    +++ ++ LF  + + VK  + F    +KMAL++L SVE AI+ALI LH++DL G N  LRVSFSK
Sbjct:   13 TDSKQYKGDRSPCAPSRVLHVRKVPIEVSEAEVVSLGVPFGKVTNLLMLKGKNQAFIEMASEEAAMTMVNYYTTATPHVRNQPVYIQYSNHRELKTDNLPNQGRAQAALQAVNAVHTGNMSLSGTATASDGGMMPGQSPVLRIIVENL-YYPVSLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNGCCTLRVEFSKLTSLNVKYNNDKSRDFTR----------LDLPSGDGQPTLDPTMQTAFGAPGIISSPYPGAAGFAPAIGFPQAGLSMQAMP--GALGPLTIPSSAMTGRMAIHGMTPTAIHS------------------VLLVSNLNPDSISPHELFILFGVYGDVHRVKILFNKKENALIQMADATQAQLAMSHLNGQRLYGKVIRVTISKHQTV--QLPREGQEDQG----LTKDFSGSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSTTDDFLKDLFASSGYTVKAFKFFQKD-RKMALIQLGSVEEAIQALIHLHNHDL-GENHHLRVSFSK 519          

Query:   75 SDNEENKKIR----REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQICDSMAKEQ------AGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  +NKK +     E  PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TDS+++  A+       AV T+N    S A  +        PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P   G  ++        +        G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +  +++E+D+  LFT+    VK  + F     KMAL+++S+VE AI+ALI+LH+Y++ G N  LRVSFSK
Sbjct:   39 ANGNDNKKFKGDDKMEAAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAASTMVNYYTTITPHLRNQPIYIQYSNHKELK-TDSALNQRAQAVLQAVTAVQTSNSSVTSTAANENTVSSAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPL--GIPNA-----AAAAAAAAASRVGMHGVSTGGNTVLLVSNLNEEMVSPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQNITEDDLRTLFTNTGGNVKAFKFFQD--HKMALLQMSTVEEAIQALIDLHNYNI-GDNHHLRVSFSK 528          

Query:   63 EEDISDNEENKKIR----REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQICDSMAKEQ------AGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            + D ++  +NKK +     E  PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TDS+++  A+       AV T+N    S A  +        PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  AA    +   L ++  P     L   +      +             G  T  +L+VSNLNE     +    +   YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +  +++E+D+  LFT+    VK  + F     KMAL+++S+VE AI+ALI+LH+Y++ G N  LRVSFSK
Sbjct:    4 DPDYANGNDNKKFKGDDKMEAAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAASTMVNYYTTITPHLRNQPIYIQYSNHKELK-TDSALNQRAQAVLQAVTAVQTSNSSVTSTAANENTVSSAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAI--AAAFAKETSLLGKASVPGALSPLGIPNAAAAAAAAAASRVGMHGVSTGGNT--VLLVSNLNE-----EVSETILCVYGDVQRVKILYNKKDSALIQMADGNQSQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQNITEDDLRTLFTNTGGNVKAFKFFQD--HKMALLQMSTVEEAIQALIDLHNYNI-GDNHHLRVSFSK 495          

Query:   75 SDNEENKKIR----REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQICDSMAKEQ------AGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  +NKK +     E  PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TDS+++  A+       AV T+N    S A  +        PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  AA    +   L ++  P     L   +      +             G  T  +L+VSNLNE     +    +   YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +  +++E+D+  LFT+    VK  + F     KMAL+++S+VE AI+ALI+LH+Y++ G N  LRVSFSK
Sbjct:   41 ANGNDNKKFKGDDKMEAAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAASTMVNYYTTITPHLRNQPIYIQYSNHKELK-TDSALNQRAQAVLQAVTAVQTSNSSVTSTAANENTVSSAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAI--AAAFAKETSLLGKASVPGALSPLGIPNAAAAAAAAAASRVGMHGVSTGGNT--VLLVSNLNE-----EVSETILCVYGDVQRVKILYNKKDSALIQMADGNQSQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQNITEDDLRTLFTNTGGNVKAFKFFQD--HKMALLQMSTVEEAIQALIDLHNYNI-GDNHHLRVSFSK 528          

Query:   93 KKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQICDSMAKEQ------AGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            KK+     PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TDS+++  A+       AV T+N    S A  +        PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  AA    +   L ++  P     L   +      +             G  T  +L+VSNLNE     +    +   YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +  +++E+D+  LFT+    VK  + F     KMAL+++S+VE AI+ALI+LH+Y++ G N  LRVSFSK
Sbjct:    4 KKLESLPAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAASTMVNYYTTITPHLRNQPIYIQYSNHKELK-TDSALNQRAQAVLQAVTAVQTSNSSVTSTAANENTVSSAQSPVLRIIIDNMYYPVTLDV-LHQIFSKFGTVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAI--AAAFAKETSLLGKASVPGALSPLGIPNAAAAAAAAAASRVGMHGVSTGGNT--VLLVSNLNE-----EVSETILCVYGDVQRVKILYNKKDSALIQMADGNQSQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQNITEDDLRTLFTNTGGNVKAFKFFQD--HKMALLQMSTVEEAIQALIDLHNYNI-GDNHHLRVSFSK 481          

Query:   60 VEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQI------------CDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTS----PLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSKQYL 1652
            ++ + +D+++ K  R    PS+VLH+R +P+DVTE EI S+  PFG ++ +++ +   QA LEM ++E A +M  YY    PH+R++  +IQYS+H  L++ +      A+ A+   N +             + +      PVLR++V++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A  AK   +G  ++  CC LR+ FS   SL++   +D  RDF R          + +  G G P  +T           +  P    A   P    A   P   + +     P + G L    L    I+        GR      T+     +L+VSNLN   I P  LF LFG YGDV RVKI++N+K  AL+Q      AQ A+  LNG  L+G+ L +  SKH  +  + P  G E++     L ++Y +S LHRFK+  S+N  NI+ PS  LH++ +   V++ED++ LF      VK  + F    +KMAL++L SVE AI ALIELH++DL G N  LRVSFSK  +
Sbjct:   18 LQANGNDSKKFKGDRSPCSPSRVLHIRKIPNDVTESEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVSMVNYYTPVPPHVRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVNTLQSGGLTLTSVPGGEGLVLSGQSPVLRIIVENLFYP-VTLEVLHQIFSKFGTVIKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNACCTLRIEFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLDTTMAAAFGAPGIISSPYAGAAGFAP----AIGFPQAGLSV-----PGVPG-LGPLALTTSAIT--------GRMAIPGMTAIPGHSVLLVSNLNPDAILPHGLFILFGVYGDVQRVKILFNKKENALVQMTDATQAQLAMSHLNGQRLHGRVLRITLSKHQSV--QLPREGHEDQG----LTKDYTNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPLVTDEDLKRLFASTGCSVKGFKFFQKD-RKMALIQLGSVEEAILALIELHNHDL-GENHHLRVSFSKSMI 530          

Query:   36 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTN-QICDSMAKEQA-----GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHF----GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            M       V  + +DN++ K  R    PS+VLH+R +P DVTE E+ S+  PFG ++ +++ +   QA LEM ++E A TM  YY   +PHLR++  +IQYS+H  L++ +      +    +A +AV + N  +  + A E        PVLR+++++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A+ AK   +G  ++  CC LR++FS   SL++   +D  RDF R          + +  G G P  E            +  P    A   P +         A P    ++ PA+ G L    L    +S        GR       G   + +L+V+NLN   I P  LF LFG YGDV RVKIM+N+K  AL+Q A    AQ A+  L+G  LYGK L    SKH  +  + P  G E++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +   V+ +D++ LFT+    VK  + F    +KMAL++L SVE AI+ALIELH++DL G N  LRVSFSK
Sbjct:    1 MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYP-VTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAI---------AFPQAAGLSVPAVPGALGPLTLTSSAVS--------GRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLPREGQEDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 520          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 528          

Query:   36 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTN-QICDSMAKEQA-----GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHF----GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSKQYL 1652
            M       V  + +DN++ K  R    PS+VLH+R +P DVTE E+ S+  PFG ++ +++ +   QA LEM ++E A TM  YY   +PHLR++  +IQYS+H  L++ +      +    +A +AV + N  +  + A E        PVLR+++++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A+ AK   +G  ++  CC LR++FS   SL++   +D  RDF R          + +  G G P  E            +  P    A   P +         A P    ++ PA+ G L    L    +S        GR       G   + +L+V+NLN   I P  LF LFG YGDV RVKIM+N+K  AL+Q A    AQ A+  L+G  LYGK L    SKH  +  + P  G E++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +   V+ +D++ LFT+    VK  + F    +KMAL++L SVE AI+ALIELH++DL G N  LRVSFSK  +
Sbjct:   32 MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYP-VTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAI---------AFPQAAGLSVPAVPGALGPLTLTSSAVS--------GRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLPREGQEDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSKSTI 554          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRD-HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 529          

Query:   75 SDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTN-QICDSMAKEQA-----GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHF----GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            +DN++ K  R    PS+VLH+R +P DVTE E+ S+  PFG ++ +++ +   QA LEM ++E A TM  YY   +PHLR++  +IQYS+H  L++ +      +    +A +AV + N  +  + A E        PVLR+++++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A+ AK   +G  ++  CC LR++FS   SL++   +D  RDF R          + +  G G P  E            +  P    A   P +         A P    ++ PA+ G L    L    +S        GR       G   + +L+V+NLN   I P  LF LFG YGDV RVKIM+N+K  AL+Q A    AQ A+  L+G  LYGK L    SKH  +  + P  G E++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +   V+ +D++ LFT+    VK  + F    +KMAL++L SVE AI+ALIELH++DL G N  LRVSFSK
Sbjct:   11 NDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYP-VTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAI---------AFPQAAGLSVPAVPGALGPLTLTSSAVS--------GRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLPREGQEDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 517          

Query:   36 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTN-QICDSMAKEQA-----GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHF----GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            M       V  + +DN++ K  R    PS+VLH+R +P DVTE E+ S+  PFG ++ +++ +   QA LEM ++E A TM  YY   +PHLR++  +IQYS+H  L++ +      +    +A +AV + N  +  + A E        PVLR+++++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A+ AK   +G  ++  CC LR++FS   SL++   +D  RDF R          + +  G G P  E            +  P    A   P +         A P    ++ PA+ G L    L    +S        GR       G   + +L+V+NLN   I P  LF LFG YGDV RVKIM+N+K  AL+Q A    AQ A+  L+G  LYGK L    SKH  +  + P  G E++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +   V+ +D++ LFT+    VK  + F    +KMAL++L SVE AI+ALIELH++DL G N  LRVSFSK
Sbjct:    1 MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYP-VTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAI---------AFPQAAGLSVPAVPGALGPLTLTSSAVS--------GRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAV--QLPREGQEDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 520          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 528          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +  +T   L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   57 PSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNM-YYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 528          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE------NAVSTTNQ------ICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRN--DNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + E      PS+VLH+R LP +VTE E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +PHLRN+  +IQYS+H  L+ TD++++  A+       AV T N       + +S       PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QY +P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                       AL P +  A       + +  +++P           +P   +          G        + +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    +Q A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +   V+EED+  LF +    VK  + F     KMAL+++++VE AI+ALI+LH+Y+L G N  LRVSFSK
Sbjct:   39 ANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELK-TDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDV-LHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTR-PDLPS---------GDGQP-----------------------ALDPAIAAAFAKETSLLAVPGALSPLA---------IPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQD--HKMALLQMATVEEAIQALIDLHNYNL-GENHHLRVSFSK 528          

Query:   36 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTD------SSMHPEAENAVSTTNQICDSMAKEQA------GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPK-ETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIA-PAIRGFLDSQDLLPREISRHDRNDNFGRTHF----GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            M       V  + +DN++ K  R    PS+VLH+R +P DVTE E+ S+  PFG ++ +++ +   QA LEM ++E A TM  YY   +PHLR++  +IQYS+H  L++ +      +    +A +AV + N         +        PVLR+++++  +  +T   L +IF  +G + +I+ +      Q  +QY++P +A+ AK   +G  ++  CC LR++FS   SL++   +D  RDF R          + +  G G P  E            +  P    A   P +         A P    ++  A+ G L    L    +S        GR       G   + +L+V+NLN   I P  LF LFG YGDV RVKIM+N+K  AL+Q A    AQ A+  L+G  LYGK L    SKH  +  + P  G E++     L +++++S LHRFK+  S+N  NI+ PS  LH++ +   V+ +D++ LFT+    VK  + F    +KMAL++L SVE AI+ALIELH++DL G N  LRVSFSK
Sbjct:    1 MNNSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATSNEGTLLPGQSPVLRIIIENLFYP-VTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTR----------LDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAI---------AFPQAAGLSVSAVPGALGPLTLTSSAVS--------GRMAIPGASGIPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHLSGQRLYGKVLRATLSKHQAV--QLPREGQEDQG----LTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKD-RKMALIQLGSVEEAIQALIELHNHDL-GENHHLRVSFSK 520          

Query:   30 FMMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQ--STDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQEL-----------------------------------KNIHVNIGGGIPKETERFRDIREFRELRDPIDTLA-----ALQPLLTHA--------------ATHPDDAMPLLRSIAPAIRGFLDSQDLLPR--------------EISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            F+M       +E D ++N++++    E  PSKV+H+R++PDD TE EIA +  PFG +  MVL++K  QALLEM+  E A  M  YY+ +   LR +   +QYS H  L+  S +SS+    +NA     Q            VLR+VVD+   ++I +  L KIF  YG + RIV Y+      G +++     A VA    NG  ++  CC LRV FS NR  L++ +E D  RD++ +P++ +EL                                   + IH+ +G   P  T          EL   +  LA     AL P    A               T      P L +I  A++G      +LP                +S H       R+      S +LIVSNLNE +++PDALF LFG YGDVTRVKIM+N+K+TALIQF     A  ALQFLNG  L+ KP+ +  S+H+       I    +E T + L ++Y +S LHRF++  S+N  NIY PS VLH++ +   V+E DI  LF    F V   R    +  KMALV+L +V+ AI++LIELH+  L   S+LR+SFSK
Sbjct:   22 FIMNGNGHAPMETDTNENKKSRIEYVETVPSKVVHIRNMPDDATEHEIALLGIPFGLLENMVLSKKANQALLEMQCLESAIMMVSYYREYQVTLRGRNLVMQYSKHQHLELHSENSSIGNAIQNANCIVQQDLSGANSGMPTTVLRVVVDNIMGQQINHTILHKIFYRYGKILRIVTYLKNNQYHGLVEFGNHIHAFVAMLHLNGQNIYTGCCSLRVQFSKNRGPLEVRQESDRCRDYLNNPLTEEELMSLRRPTAGSERHHNSNPGHVSSNFQNSVVTNMAHQGIHLPVGMIAPPNTSSM----GINELTAQLAALAQQSGLALTPAAVAATASFMALTSQNSGPGTQSMSGTPNLSTILAALQGGAVQTGVLPHMSGGNASVMGSVQTPVSSHVTPVGV-RSPPNNNGSTVLIVSNLNEDRVYPDALFTLFGVYGDVTRVKIMFNKKDTALIQFNDPHQALTALQFLNGQRLWDKPMKIAVSRHN-------IVQLPKEDTENGLTKDYTNSLLHRFRKPNSKNFQNIYPPSHVLHLSNIPPSVTENDIRVLFATKGFEVTGFRFMKDN--KMALVQLETVDLAIQSLIELHNSQLTENSHLRISFSK 617          

Query:   30 FMMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQ--STDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQEL-----------------------------------KNIHVNIGGGIPKETERFRDIREFRELRDPIDTLA-----ALQPLLTHA--------------ATHPDDAMPLLRSIAPAIRGFLDSQDLLPR--------------EISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            F+M       +E D ++N++++    E  PSKV+H+R++PDD TE EIA +  PFG +  MVL++K  QALLEM+  E A  M  YY+ +   LR +   +QYS H  L+  S +SS+    +NA     Q            VLR+VVD+   ++I +  L KIF  YG + RIV Y+      G +++     A VA    NG  ++  CC LRV FS NR  L++ +E D  RD++ +P++ +EL                                   + IH+ +G   P  T          EL   +  LA     AL P    A               T      P L +I  A++G      +LP                +S H       R+      S +LIVSNLNE +++PDALF LFG YGDVTRVKIM+N+K+TALIQF     A  ALQFLNG  L+ KP+ +  S+H+       I    +E T + L ++Y +S LHRF++  S+N  NIY PS VLH++ +   V+E DI  LF    F V   R    +  KMALV+L +V+ AI++LIELH+  L   S+LR+SFSK
Sbjct:   13 FIMNGNGHAPMETDTNENKKSRIEYVETVPSKVVHIRNMPDDATEHEIALLGIPFGLLENMVLSKKANQALLEMQCLESAIMMVSYYREYQVTLRGRNLVMQYSKHQHLELHSENSSIGNAIQNANCIVQQDLSGANSGMPTTVLRVVVDNIMGQQINHTILHKIFYRYGKILRIVTYLKNNQYHGLVEFGNHIHAFVAMLHLNGQNIYTGCCSLRVQFSKNRGPLEVRQESDRCRDYLNNPLTEEELMSLRRPTAGSERHHNSNPGHVSSNFQNSVVTNMAHQGIHLPVGMIAPPNTSSM----GINELTAQLAALAQQSGLALTPAAVAATASFMALTSQNSGPGTQSMSGTPNLSTILAALQGGAVQTGVLPHMSGGNASVMGSVQTPVSSHVTPVGV-RSPPNNNGSTVLIVSNLNEDRVYPDALFTLFGVYGDVTRVKIMFNKKDTALIQFNDPHQALTALQFLNGQRLWDKPMKIAVSRHN-------IVQLPKEDTENGLTKDYTNSLLHRFRKPNSKNFQNIYPPSHVLHLSNIPPSVTENDIRVLFATKGFEVTGFRFMKDN--KMALVQLETVDLAIQSLIELHNSQLTENSHLRISFSK 608          

Query:   75 SDNEENKKIR---REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQ--STDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQEL-----------------------------------KNIHVNIGGGIPKETERFRDIREFRELRDPIDTLA-----ALQPLLTHA--------------ATHPDDAMPLLRSIAPAIRGFLDSQDLLPR--------------EISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            +D  ENKK R    E  PSKV+H+R++PDD TE EIA +  PFG +  MVL++K  QALLEM+  E A  M  YY+ +   LR +   +QYS H  L+  S +SS+    +NA     Q            VLR+VVD+   ++I +  L KIF  YG + RIV Y+      G +++     A VA    NG  ++  CC LRV FS NR  L++ +E D  RD++ +P++ +EL                                   + IH+ +G   P  T          EL   +  LA     AL P    A               T      P L +I  A++G      +LP                +S H       R+      S +LIVSNLNE +++PDALF LFG YGDVTRVKIM+N+K+TALIQF     A  ALQFLNG  L+ KP+ +  S+H+       I    +E T + L ++Y +S LHRF++  S+N  NIY PS VLH++ +   V+E DI  LF    F V   R    +  KMALV+L +V+ AI++LIELH+  L   S+LR+SFSK
Sbjct:   11 TDTNENKKSRIEYVETVPSKVVHIRNMPDDATEHEIALLGIPFGLLENMVLSKKANQALLEMQCLESAIMMVSYYREYQVTLRGRNLVMQYSKHQHLELHSENSSIGNAIQNANCIVQQDLSGANSGMPTTVLRVVVDNIMGQQINHTILHKIFYRYGKILRIVTYLKNNQYHGLVEFGNHIHAFVAMLHLNGQNIYTGCCSLRVQFSKNRGPLEVRQESDRCRDYLNNPLTEEELMSLRRPTAGSERHHNSNPGHVSSNFQNSVVTNMAHQGIHLPVGMIAPPNTSSM----GINELTAQLAALAQQSGLALTPAAVAATASFMALTSQNSGPGTQSMSGTPNLSTILAALQGGAVQTGVLPHMSGGNASVMGSVQTPVSSHVTPVGV-RSPPNNNGSTVLIVSNLNEDRVYPDALFTLFGVYGDVTRVKIMFNKKDTALIQFNDPHQALTALQFLNGQRLWDKPMKIAVSRHN-------IVQLPKEDTENGLTKDYTNSLLHRFRKPNSKNFQNIYPPSHVLHLSNIPPSVTENDIRVLFATKGFEVTGFRFMKDN--KMALVQLETVDLAIQSLIELHNSQLTENSHLRISFSK 594          

Query:   93 KKIRRE--IP---PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDT-LAALQPLLTH--AATHPDDAMPLLR-SIAPAIRGFLDSQ---DLLPRE-----ISRHDRNDN---FGRTHFGEKTS--PLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGS-NLRVSFSKQYL 1652
            KK+R E  +P   PSKV+H+R++P D  E +I  +  PFG ++ MVL +K  QALLEM+T+E A  M +YY +H   +R +   IQYS+H  L++   +    AENA+S+ N +  +  +++   VLR++V++     +T   L KIF  +G++++IVI+      Q  IQ      A  AK + N   ++  CC LR++FS   +L++   ++  RDF              VN                     R P D  LA   P L     AT     +P L  + AP +   LD Q    + P       +S H        FG+     + S   +L+VSNL++ KI PDALF LFG YGDV RVKIMYN+K+ ALIQF     AQ+ALQ LNGV L+G+PL + FS+H +++   P  G++   T     + + +S LHRFK+  S+N  NI+ PS++LH++ +  +V EE I+A+F D  F V  I+ F    KKMALV++ +VE ++ ALI+LH+Y L  + +LRVSFSK  +
Sbjct:   57 KKVRLENHVPEPEPSKVVHIRNVPQDAIENDIVQLGVPFGQMTNMVLAKKKNQALLEMKTQETATKMVDYYAQHPVTIRGRTVIIQYSNHAELKTEQPNA--AAENALSSANGLVSTYQQDEPPSVLRVIVENL-MAPVTIEVLHKIFSRFGMVQKIVIFSKNNTFQALIQMGSSTEALAAKLVLNDQNIYNGCCTLRIDFSKLNTLNVKFNNEKSRDFT-------------VN---------------------RAPGDNPLAYFDPNLAPHLGATLFPAMIPGLEFAQAPILAQTLDGQPNLGIFPAAAQLPAMSMHSLTSPVAPFGQAIMAPQASVNSILLVSNLDDEKITPDALFTLFGVYGDVQRVKIMYNKKDNALIQFTDASQAQQALQNLNGVRLFGRPLKIAFSRHAQVA--LPKEGADAGLT-----KIFTNSPLHRFKKPHSKNFQNIFPPSQILHLSNIPQEVPEEKIKAIFEDFGFNVVAIKFFQKE-KKMALVQMPTVEDSVIALIKLHNYQLSANYHLRVSFSKSVI 554          

Query:   30 FMMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQ--STDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGG------------------IPKETERFRDI------------REFRELRDPIDTLA-------------------ALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFG---------RTHF---------GEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            F+M       +E D ++N++++    E  PSKV+H+R++PDD TE EIA +  PFG +  MVL++K  QALLEM+  E A  M  YY+ +   LR +   +QYS H  L+  S ++S+    +NA     Q            VLR+VVD+   ++I +  L KIF  YG + RIV Y+      G +++     A VA    NG  ++  CC LRV FS NR  L++ +E +  RD++ +P++ +EL ++     GG                  +P  T +   +                EL   +  LA                   AL    +   T      P L +I  A++G      +LP     H    N G          TH              S +LIVSNLNE +++PDALF LFG YGDVTRVKIM+N+K+TALIQF     A  ALQFLNG  L+ KP+ +  S+H+       I    +E T + L ++Y +S LHRF++  S+N  NIY PS VLH++ +   V+E DI  LF    F V   R    +  KMALV+L +V+ AI++LIELH+  L   S+LR+SFSK
Sbjct:   13 FIMNGNGHAPMETDTNENKKSRIEYVETVPSKVVHIRNMPDDATEHEIALLGIPFGLLENMVLSKKANQALLEMQCLESAIMMVSYYREYQVTLRGRTLVMQYSKHQHLELHSENTSIGNAIQNANCIVQQDLSGANSGMPTTVLRVVVDNIMGQQINHTILHKIFYRYGKILRIVTYLKNNQYHGLVEFGNHIHAFVAMLHLNGQNIYTGCCSLRVQFSKNRGPLEVRQESEKCRDYLNNPLTEEELLSLRRPTAGGGHHNNNPGHNSSNFQNSVVPNMTHQGIHLPVGMIAPPNANNMGINELTAQLAALAQQSGLALTPAAAAATASFMALTSQTSGPGTQSMSGTPNLSAILAALQGGAVQTGVLP-----HISGGNAGVMGSVQSPVSTHVTPVGVRPPPNNNGSTVLIVSNLNEDRVYPDALFTLFGVYGDVTRVKIMFNKKDTALIQFTDPHQALTALQFLNGQRLWDKPMKIAVSRHN-------IVQLPKEDTENGLTKDYTNSLLHRFRKPNSKNFQNIYPPSHVLHLSNIPPSVTENDIRVLFATKGFEVTGFRFMKDN--KMALVQLETVDLAIQSLIELHNSQLTENSHLRISFSK 607          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE---NAVS--------TTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSKQYL 1652
            ++  ++KK+R E     PPS+V+H+R LP++V+E E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +P +RN   FIQYS+H  L+ TDS+++  A+    AVS        +++   DS+      PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +Q+S+P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                 P+D         + AA    D+  LL +I+P       +       +S H                 +L+ SNLN+  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    AQ A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ + DDV+EED+  LF+++   VK  + F    +KMAL+++S+VE AI+ALI+LH+YD+  G  LRVSFSK  +
Sbjct:   34 ANGSDSKKLRVEDSMDSPPSRVIHIRKLPNEVSETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELK-TDSALNQRAQAVLQAVSAVQEGGSPSSDTAGDSILSPAPSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------PVDP--------SMAAALSKDSTSLLGAISPLSAAAAAAAAAGRVALSGHSGGGG------------VLLASNLNDEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQAQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNVRDDVTEEDLRLLFSNSGGTVKAFKFFQD--RKMALLQMSTVEEAIQALIDLHNYDMGRGHRLRVSFSKSTI 518          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE---NAVS--------TTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREIS-------RHDRNDNFGRTHFG--EKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSKQYL 1652
            ++  ++KK+R E     PPS+V+H+R LP++V+E E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +P +RN   FIQYS+H  L+ TDS+++  A+    AVS        +++   DS+      PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +Q+S+P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                 P+D         + AA    D+  LL S +  +  +  S    P  +                GR           +L+ SNLN+  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    AQ A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ + DDV+EED+  LF+++   VK  + F    +KMAL+++S+VE AI+ALI+LH+YD+  G  LRVSFSK  +
Sbjct:   34 ANGSDSKKLRVEDSMDSPPSRVIHIRKLPNEVSETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELK-TDSALNQRAQAVLQAVSAVQEGGSPSSDTAGDSILSPAPSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------PVDP--------SMAAALSKDSTSLLGSPSGMVTSY-SSAGAYPSSLGAISPLSAAAAAAAAAGRVALSGHSGGGGVLLASNLNDEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQAQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNVRDDVTEEDLRLLFSNSGGTVKAFKFFQD--RKMALLQMSTVEEAIQALIDLHNYDMGRGHRLRVSFSKSTI 538          

Query:   60 VEEDISDNEENKKIRRE-----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            + +  S+  ++KK+R E      PPS+VLH+R LP++V+E E+ ++  PFG ++ ++  +   QA LE+ T+E A TM  YY   +PH+RN   FIQYS+H  L++ ++       N  + ++   D      + PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QY++  SA+ AK   +G  ++  CC LR+++S   +L++   +D  RD+ R P  P          G G P                       A+ P  + AA    D+  LL +++P       +       +S H  N            S +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    AQ A+  LNG  +Y K + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +  D++E+D+  LFT++   VK  + F    +KMAL++LS+VE AI+ LI+LH+Y++ G N  LRVSFSK
Sbjct:   12 ISDGTSNGSDSKKLRVEDRVGDAPPSRVLHIRKLPNEVSETEVIALGLPFGKVTNILTLKGKNQAFLELSTEEAAITMVNYYSAVTPHVRNVPVFIQYSNHKELKTDNA-------NQSTPSSGSSDGTLTSPSSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQYNDAGSAQQAKVALDGQNIYNACCTLRIDYSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------------AVDP--SMAAAFSKDSNSLLGALSPLSAAAAAAAAAGRVALSGHSGN------------SGVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADLNQAQLAMSHLNGQKMYSKIIRVTMSKHQTV--QLPRDGLDDQG----LTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQDITEDDLRVLFTNSGGTVKAFKFFQD--RKMALIQLSTVEEAIQCLIDLHNYNM-GDNHHLRVSFSK 482          

Query:   60 VEEDISDNEENKKIRRE-----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSKQYL 1652
            + +  S+  ++KK+R E      PPS+VLH+R LP++V+E E+ ++  PFG ++ ++  +   QA LE+ T+E A TM  YY   +PH+RN   FIQYS+H  L++ ++       N  + ++   D      + PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QY++  SA+ AK   +G  ++  CC LR+++S   +L++   +D  RD+ R P  P          G G P                       A+ P  + AA    D+  LL  I P     L +         R   + + G        S +L+VSNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ A    AQ A+  LNG  +Y K + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ +  D++E+D+  LFT++   VK  + F    +KMAL++LS+VE AI+ LI+LH+Y++ G N  LRVSFSK  +
Sbjct:   34 ISDGTSNGSDSKKLRVEDRVGDAPPSRVLHIRKLPNEVSETEVIALGLPFGKVTNILTLKGKNQAFLELSTEEAAITMVNYYSAVTPHVRNVPVFIQYSNHKELKTDNA-------NQSTPSSGSSDGTLTSPSSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQYNDAGSAQQAKVALDGQNIYNACCTLRIDYSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------------AVDP--SMAAAFSKDSNSLLGKI-PGALSPLSAAAAAAAAAGRVALSGHSGN-------SGVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADLNQAQLAMSHLNGQKMYSKIIRVTMSKHQTV--QLPRDGLDDQG----LTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQDITEDDLRVLFTNSGGTVKAFKFFQD--RKMALIQLSTVEEAIQCLIDLHNYNM-GDNHHLRVSFSKSTI 511          

Query:   75 SDNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE---NAVS--------TTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            ++  ++KK+R E     PPS+V+H+R LP++V+E E+ ++  PFG ++ +++ +   QA LE+ T+E A TM  YY   +P +RN   FIQYS+H  L+ TDS+++  A+    AVS        +++   DS+      PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +Q+S+P +A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P          G G P                 P+D         + AA    D+  LL +I+P       +       +S H                 +L+ SNLN+              YGDV RVKI+YN+K++ALIQ A    AQ A+  LNG  +YGK + V  SKH  +  + P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ + DDV+EED+  LF+++   VK  + F    +KMAL+++S+VE AI+ALI+LH+YD+  G  LRVSFSK
Sbjct:    4 ANGSDSKKLRVEDSMDSPPSRVIHIRKLPNEVSETEVIALGLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELK-TDSALNQRAQAVLQAVSAVQEGGSPSSDTAGDSILSPAPSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKLSLDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYTR-PELPA---------GDGQP-----------------PVDP--------SMAAALSKDSTSLLGAISPLSAAAAAAAAAGRVALSGHSGGGG------------VLLASNLNDE----------VSVYGDVQRVKILYNKKDSALIQMADGNQAQLAMSHLNGQKMYGKIIRVTLSKHQTV--QLPREGLDDQG----LTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNVRDDVTEEDLRLLFSNSGGTVKAFKFFQD--RKMALLQMSTVEEAIQALIDLHNYDMGRGHRLRVSFSK 475          

Query:   75 SDNEENKKIRREIP---PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSM-----HPEAENAVSTTNQICDSMAKEQA------GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVR 740
            ++  E+KK + +     PSKVLH+R LP++ TE E+ ++A PFG ++ +++ +   QA LEM ++E A     +Y    P LRN+  ++QYS + +L++ +S+      H   E        + +    E+        P+L ++V++  +  IT   L  +F  YG + +I+I+      Q  +Q+++  +A  AK + +G  ++  CC LRV FS   +L++   ++  RD  R
Sbjct:    8 AEGSESKKFKGDSSDELPSKVLHIRKLPENATEAEVVTLALPFGRVTNILMLKGKSQAFLEMASEEAAVAAVTFYSTDPPVLRNQPVYVQYSTYKSLKTDNSAYQAARSHARREQKAQAAMMVANGSDSEETNSAAPQSPILHIIVENLLY-PITLEVLHHVFSKYGTVLKIIIFNKNSQYQALMQFADASNAHQAKTMLDGQNIYNGCCTLRVGFSRLTNLNVKYNNEKSRDLTR 242          

Query: 1209 ALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSKQYL 1652
             +  LNG  +YGKP+ V  S++  +  + P  GS      D L  +++DS LHRF+R  ++N  +I+ PS  LH++ +   V E+D++ LF  N   VK ++ F ++  KMALV++ S+E AI+ L ELH+++L  +  LRVSFSK  +
Sbjct:   21 VMNHLNGQRMYGKPIRVTSSRYQTV--QLPRDGS------DSLTCDFSDSPLHRFRRMGAKNFHHIFPPSVTLHLSNIPSSVLEDDLKTLFESNGCVVKALKFF-ATDHKMALVQMESLEEAIQTLAELHNHELEKNRLLRVSFSKSVI 160          

Query:   75 SDNEENKKIRREIP---PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSM-----HPEAENAVSTTNQICDSMAKEQA------GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVF 650
            ++  E+KK + +     PSKVLH+R LP++ TE E+ ++A PFG ++ +++ +   QA LEM ++E A     +Y    P LRN+  ++QYS + +L++ +S+      H   E        + +    E+        P+L ++V++  +  IT   L  +F  YG + +I+I+      Q  +Q+++  +A  AK    G  V+
Sbjct:    1 AEGSESKKFKGDSSDELPSKVLHIRKLPENATEAEVVTLALPFGRVTNILMLKGKSQAFLEMASEEAAVAAVTFYSTDPPVLRNQPVYVQYSTYKSLKTDNSAYQAARSHARREQKAQAAMMVANGSDSEETNSAAPQSPILHIIVENLLY-PITLEVLHHVFSKYGTVLKIIIFNKNSQYQALMQFADASNAHQAKTANPGWSVY 205          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQS---LDISREDDLVRDF-VRHPVSPQELKNIHVNIGGGIPKETERFRDIR-EFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSE-EEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEE 1463
            PS V+H+R L     E ++      FG + ++V+     QAL+E E  E A            ++  +  +  +S   T Q         A++ V+ TN I            L L V++  +  IT   +  I   YG+++RIVI+   G VQ    +    SA+ AK+  NG  ++  CC L++ ++  +    L++ R D    D+ +  P  P   +     + G  P     + + +  +       +   +  P      T P                        P   + H+     G    G   + +++V N+N + ++   LF L   YG+V ++K + ++    +IQ A      RA+  LN   L+G+ L ++ SK   I     +AG   E   G    R++  S+ +RF   +  + + I  PS +LH      + SE+
Sbjct:   10 PSPVVHIRGLASSADESQVMEALQEFGTVRHVVMMPHRRQALVEFERLEDARACVAGTAGDPVYVGGQPAYCNFS---TSQRISRKGGTPADD-VARTNHI------------LLLTVNNALY-PITTEVIHTICSPYGVVQRIVIFKKNG-VQALRTFDSIPSAQQAKSSLNGADIYSGCCTLKIEYAKERKPARLNVYRNDSETWDYTLEGPCVPNGQQKKQPALLGDHPSTMRGYGNQQGTYCPQNYSFNNYTSGSPFGNARPTTPMSG---------------------PGTCAPHNNPCPMG----GSAANRVMMVYNMNPSVMNCSRLFNLVCLYGNVEKIKFLKSKPGVGMIQMADAASVDRAVANLNTAQLFGQKLSLSVSKQQEI-----VAGQAFELEDGSDSFRDFVGSRHNRFSTHEQASKNRILPPSAILHFYSAPPEFSEQ 416          

Query:  114 PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKN 770
            PPS V+HVR L D   E ++      FG ISY+V+  K  QAL+E E  E + +   Y    S ++  +  +  +S   T Q       PE       +N I   +      P+  +  D           L+ I    G ++RIVI+   G+ Q    +    SA+ AK+  NG  ++  CC L+V ++    L++ + D    D+    +   + +N
Sbjct:   46 PPSAVVHVRGLSDAALESDLVEAVQHFGPISYVVMMPKKRQALVEFEDLESSRSCVNYSSTGSIYVCGQPAYFNFS---TSQKISRPGGPEDNR---NSNHI---LLFTILNPIYPITTD----------VLYTICNPCGPVQRIVIFRKNGL-QAMATFDSVQSAQRAKSSLNGADIYSGCCTLKVEYAKPTRLNVFKNDSETWDYTNPGLKAGQAEN 244          

Query: 1053 LLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEE-ATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKF-RVKKIRVFNS-SGKKMA-LVELSSVESAIEALIELHDYDLCGSN------LRVSFS 1640
            +L+V   +  +I+ D +F +   +G+V +VK + ++   A+++        RA+  LN   ++GK +++  SK   I     + G   E   G   ++++  S+ +RF  A+    + I +P+ VLH      D++ E    L  +    R    + F+  S K M+ L+E  +   A+EAL  ++ + L  +N      L++ FS
Sbjct:  316 VLMVYGFDAERINCDRVFNILCLFGNVEKVKFLKSKPGAAMVEMGDPYAVDRAVSHLNMSQIFGKKINLCVSKQQSI-----VPGQAYELPDGTNSYKDFTGSRNNRFANAEKAAKNRIQQPTTVLHFFNAPMDITAEIFMQLCDEMSIARPLSFKAFSGKSDKSMSGLMEWENKNDAMEALACINHHSLKNANGPYPYTLKLCFS 516          

Query: 1056 LIVSNLNEAKIHPDAL----FKLFGCYGDVTRVKIMYNR-KNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHD 1277
            L VS LNE KI+   L    F LF  +G+V +V + + + +  A I   T + A  A   LNG   +GKPL V FSK +
Sbjct:   30 LYVSQLNE-KINMQRLRVNLFLLFATFGEVLKVSMNFKKQRGQAFITMRTIDQASLAQISLNGERFFGKPLKVEFSKSE 107          

Query: 1047 SPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGS-NLRVSFSK 1643
            SPL++VSNLNE  I  DALF LFGCYGDV RVKI++N+K+TAL+QFA    AQ A+  LNGV ++GK + V  SKH  +S   P  G +   T D     Y +S LHRFK+  S+N  NI+ PS+ LH++ + + V+EE++ ++F D    V   R F    +KMA + +++ E AI+ALI++H+Y +  + +LRVSF++
Sbjct:  277 SPLVLVSNLNEEMISCDALFTLFGCYGDVQRVKILFNKKDTALVQFANVHQAQTAIGHLNGVRVFGKEMKVTNSKHTSVS--LPKEGEDTNLTKD-----YMNSPLHRFKKPGSKNFQNIFPPSRTLHLSNIPESVTEEELTSMFEDCG-DVADFR-FLPKDRKMAHLSMATTEEAIDALIKMHNYKISETHHLRVSFAR 467          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICD--------SMAKEQA---GPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVR 740
            SKVLH+R++  + T+ EI ++  P+G ++ +++ +   QA LEM+TKE A  +   Y    P +R ++ +IQYS+H  L +T+ S H      +S+++             +A E     G +LR++V++  +  IT   L +IF  YG + +IVI+      Q  +Q+S+   A+ AK   +G  ++  CC LR+++S  ++L +   +D  RD+ R
Sbjct:    2 SKVLHLRNVAAEATDAEIIALGIPYGRVTNVLMLKGKNQAFLEMKTKENAMALMNSYSYIPPSIRGRQIYIQYSNHQEL-TTNESQHSPGVRGLSSSHLGAGIGSLTSGLGIAGELPSVNGCILRIIVENMLY-PITIEVLNQIFTKYGTVLKIVIFTRNNQFQALVQFSQSTEARAAKCSLDGQNIYNGCCTLRIDYSKLKTLSVKYNNDKTRDYTR 217          

Query: 1209 ALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGS-NLRVSFSKQ 1646
            A+  LNGV ++GK + V  SKH  +S   P  G +   T D     Y +S LHRFK+  S+N  NI+ PS+ LH++ + + V+EE++ ++F D    V   R F    +KMA + +++ E AI+ALI++H+Y +  + +LRVSF++ 
Sbjct:    1 AIGHLNGVRVFGKEMKVTNSKHTSVS--LPKEGEDTNLTKD-----YMNSPLHRFKKPGSKNFQNIFPPSRTLHLSNIPESVTEEELTSMFEDCG-DVADFR-FLPKDRKMAHLSMATTEEAIDALIKMHNYKISETHHLRVSFARS 138          

Query:  114 PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNR-QSLDISREDDLVRDF 734
            PPS+V+H R++ D   E ++  +  PFG I+Y+ L  K  QAL+E E+ E A  +  Y Q     +  ++ F+ YS    ++  D  ++ ++  A +  + I           +L  +++  +   +  LH  KI    G + RIVI+   G+        +  SA+ A A+ NG  ++  CC L++++S + + L++ + DD   D+
Sbjct:    4 PPSRVIHCRAVADGCKETDLIQVLQPFGTITYVTLLPKIRQALVEFESLESAIAVVTYSQTSPLTVLGRQMFVNYSKSQEIKR-DKVLNGDSNGACAEASNI-----------LLLTIINPLHPINVKILH--KICSPSGKVLRIVIFHKNGL--------QALSAERALAVLNGQDIYAGCCTLKIDYSKKAKKLNVFKNDDETWDY 189          

Query: 1053 LLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDI-EALFTDNKFRVKKIRVFNSSGK---KMALVELSSVESAIEALIELHDYDLCGSNLRVSFS 1640
            +++V  L++ K++ D LF L  CYG+V ++K +  +  TA+ +          ++ L+ + L+ + L  +FSK D +   A +    +   G    + +++SK +RF  A + + + ++ P KVLH      D +EE I E          K I++F+ SG       L+E  SV  A+EAL+  + Y +  S  +  F+
Sbjct:  305 VIMVYGLDKDKMNCDRLFNLLCCYGNVIKIKFLLGKPGTAMAELHEHVACNTVMENLSKMTLFDQQLEFSFSKQDYLVEPANVPNLPD---GSPSFKSFDNSKNNRFTSATASSKNRVFTPMKVLHFFNAPVDCTEEQIREMCQVCGVAPPKTIKMFSPSGNARTSSGLIEWESVTQALEALVMCNHYVIRNSTAKTIFT 501          

Query:  117 PSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPF----SAKVAKALTNGLCVFPRCCVLRVNFSN-RQSLDISREDDLVRDFVR 740
            PS+V+HVR + D+  E ++    + +G+IS + +  K  QAL+E E    A T+    Q  +P +   R    Y+++   +    ++H  +E                Q   +L + + +  +   T++ L  IF   G+++RIVI+   G+ Q  ++ S  F    +A+ AK   NG  ++  C  L++      Q L++ + D    D+ +
Sbjct:   46 PSRVVHVRGVADEAREQDLMQCLSQYGNISCITMMPKIRQALVEFEEIACANTLVNQTQMGNPVILCGR--PAYANYSKSKQISRNVHVRSET---------------QPNKILLITIINPQYVVTTDI-LHTIFSKQGMVQRIVIFRKSGL-QAMVEESR-FDCVEAARHAKETLNGADIYTGCNTLKIESQGYAQQLNVRKNDSETYDYTQ 238          

Query:   75 SDNEENKKIR-REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE-NAVSTT----NQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            S   ++KK+R  E  PS+V+H+R LP +  + E+ ++  PFG ++ ++  R   QA LEM T+E A TM  YY    PH+RN   ++Q+S+H  L++  +S   +A   AVS      +++ D +A   + PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QYS+P  A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P                         + R   DP           + AA    D+ PLL  I     G L+         +   R    G+   G     +L+ SNLNE  + P +LF LFG YGDV RVKI+YN+K++ALIQ      AQ A+  LNG  +YGK + V  SKH  ++   P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ ++ DV+EED+  LF++    VK  + F    +KMAL+++S+VE AI+ALI+LH+Y++ G+N  LRVSFSK
Sbjct:   36 STGSDSKKLRVEEALPSRVIHIRRLPTEAMDAEVIALGLPFGKVTNILTLRGKNQAFLEMGTEEAAITMVNYYNTVPPHVRNSPVYVQFSNHKELKTDAASQRTQAVLQAVSAVQPPGSEVQDVLAAA-SSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQYSDPVQAQHAKLALDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYSR-PELPAG-----------------------DSRPTLDP-----------SVAAALSKDSTPLLCKIP----GALNPLSAAAAAAAAAGRVALPGQAGSGG----VLLASNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMCDPSQAQLAMSHLNGQKMYGKIIRVTLSKHQSVA--LPRDGLDDQG----LTKDFTNSSLHRFKKPGSKNFQNIFPPSATLHLSNVLQDVTEEDLRLLFSNTGGTVKAFKFFQD--RKMALIQMSTVEEAIQALIDLHNYNM-GANQHLRVSFSK 512          

Query:   75 SDNEENKKIRREI----PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGP--VLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQ-------ELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMP-LLRSI---APAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + ++     PS+VLH+R LP D+TE E+ S+  PFG ++ +++ +   QA LEM ++E A+ M  YY    P +R +  F+Q+S+H  L++ +S     A+ A+   +      A     P  VLR+VV++  +  ++   L +IF  +G + RI+++      Q  +QY+E  SA+ AK   +G  ++  CC LR++FS   +L++   +D  RDF R P  P        E + +    G GI   +        F           ALQP+ +  A      +P  L S+   A A  GF       P   + H                 +++VSNLN  ++ P  LF LFG YGDV RVKI++N+K  AL+Q +    AQ A+  LNG  L+G+PL +  SKH  +  + P  G E++     L ++Y+ S LHRFK+  S+N+SNI+ PS  LH++ +   V E+D++ LF+ +   VK  + F     KMAL+++ SVE AIE LI+LH++DL G N  LRVSFSK
Sbjct:    5 ANGNDSKKFKGDLRGPNVPSRVLHIRKLPIDITETEVISLGLPFGDVTNLLMLKAKNQAFLEMNSEEAAQNMVGYYSTVMPIIRQQPVFVQFSNHKELKTDNSPNQERAQAALRALSSSHVDTAALVVAPSSVLRVVVENLLYP-VSLDALCQIFSKFGTVLRIIVFTKNNQFQALLQYAEGASAQAAKVSLDGQNIYNGCCTLRISFSKLTTLNVKYNNDKSRDFTR-PDLPSGDGQPTMEHQAMATAFGPGIISASPYTGATHAF-------PPAFALQPVSSPYAGLTMSGLPGTLASLTLPAGARLGF-------PAIPAGHS----------------VVLVSNLNAERVTPHCLFILFGVYGDVMRVKILFNKKENALVQMSDSTQAQLAMSHLNGQRLHGRPLRITLSKHTSV--QLPREGHEDQG----LTKDYSSSPLHRFKKPGSKNYSNIFPPSATLHLSNIPPSVVEDDLKMLFSSSGAVVKAFKFFQKD-HKMALIQMGSVEEAIECLIQLHNHDL-GENHHLRVSFSK 506          

Query:   75 SDNEENKKIRREI----PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGP--VLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQ-------ELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMP-LLRSI---APAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + ++     PS+VLH+R LP D+TE E+ S+  PFG ++ +++ +   QA LEM ++E A+ M  YY    P +R +  F+Q+S+H  L++ +S     A+ A+   +      A     P  VLR+VV++  +  ++   L +IF  +G + RI+++      Q  +QY+E  SA+ AK   +G  ++  CC LR++FS   +L++   +D  RDF R P  P        E + +    G GI   +        F           ALQP+ +  A      +P  L S+   A A  GF       P   + H                 +++VSNLN  ++ P  LF LFG YGDV RVKI++N+K  AL+Q +    AQ A+  LNG  L+G+PL +  SKH  +  + P  G E++     L ++Y+ S LHRFK+  S+N+SNI+ PS  LH++ +   V E+D++ LF+ +   VK  + F     KMAL+++ SVE AIE LI+LH++DL G N  LRVSFSK
Sbjct:   58 ANGNDSKKFKGDLRGPNVPSRVLHIRKLPIDITETEVISLGLPFGDVTNLLMLKAKNQAFLEMNSEEAAQNMVGYYSTVMPIIRQQPVFVQFSNHKELKTDNSPNQERAQAALRALSSSHVDTAALVVAPSSVLRVVVENLLYP-VSLDALCQIFSKFGTVLRIIVFTKNNQFQALLQYAEGASAQAAKVSLDGQNIYNGCCTLRISFSKLTTLNVKYNNDKSRDFTR-PDLPSGDGQPTMEHQAMATAFGPGIISASPYTGATHAF-------PPAFALQPVSSPYAGLTMSGLPGTLASLTLPAGARLGF-------PAIPAGHS----------------VVLVSNLNAERVTPHCLFILFGVYGDVMRVKILFNKKENALVQMSDSTQAQLAMSHLNGQRLHGRPLRITLSKHTSV--QLPREGHEDQG----LTKDYSSSPLHRFKKPGSKNYSNIFPPSATLHLSNIPPSVVEDDLKMLFSSSGAVVKAFKFFQKD-HKMALIQMGSVEEAIECLIQLHNHDL-GENHHLRVSFSK 559          

Query:   75 SDNEENKKIR-REIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAE-NAVSTT----NQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            S + ++KK+R  E  PS+V+H+R LP +  + E+ ++  PFG ++ ++  R   QA LEM T+E A TM  YY    PH+RN   ++Q+S+H  L++  +S   +A   AVS      +++ D +A   + PVLR+++D+  +    ++ L +IF  +G + +I+ +      Q  +QYS+P  A+ AK   +G  ++  CC LR++FS   +L++   +D  RD+ R P  P                                  D+   L P  + AA    D+ PLL  I     G L+         +   R    G+   G     +L+ SNLNE              YGDV RVKI+YN+K++ALIQ      AQ A+  LNG  +YGK + V  SKH  ++   P  G +++     L +++ +S LHRFK+  S+N  NI+ PS  LH++ ++ DV+EED+  LF++    VK  + F    +KMAL+++S+VE AI+ALI+LH+Y++ G+N  LRVSFSK
Sbjct:   30 SPSSDSKKLRVEEALPSRVIHIRRLPTEAMDAEVIALGLPFGKVTNILTLRGKNQAFLEMGTEEAAITMVNYYNTVPPHVRNSPVYVQFSNHKELKTDAASQRTQAVLQAVSAVQPPGSEVQDVLAAA-SSPVLRIIIDNMFYPVTLDV-LQQIFSKFGTVMKIITFTKNNQFQALLQYSDPVQAQHAKLALDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYSR-PELPAG--------------------------------DSRPTLDP--SVAAALSKDSTPLLCKIP----GALNPLSAAAAAAAAAGRVALPGQAGSGG----VLLASNLNEE----------VRVYGDVQRVKILYNKKDSALIQMCDPSQAQLAMSHLNGQKMYGKIIRVTLSKHQSVA--LPRDGLDDQG----LTKDFTNSSLHRFKKPGSKNFQNIFPPSATLHLSNVLQDVTEEDLRLLFSNTGGTVKAFKFFQD--RKMALIQMSTVEEAIQALIDLHNYNM-GANQHLRVSFSK 496          

Query:   75 SDNEENKKIRREI----PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGP--VLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQ-------ELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMP-LLRSI---APAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLN-EAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN--LRVSFSK 1643
            ++  ++KK + ++     PS+VLH+R LP D+TE E+ S+  PFG ++ +++ +   QA LEM ++E A+ M  YY    P +R +  F+Q+S+H  L++ +S     A+ A+   +      A     P  VLR+VV++  +  ++   L +IF  +G + RI+++      Q  +QY+E  SA+ AK   +G  ++  CC LR++FS   +L++   +D  RDF R P  P        E + +    G GI   +        F           ALQP+ +  A      +P  L S+   A A  GF       P   + H                 +++VSNLN E           +  YGDV RVKI++N+K  AL+Q +    AQ A+  LNG  L+G+PL +  SKH  +  + P  G E++     L ++Y+ S LHRFK+  S+N+SNI+ PS  LH++ +   V E+D++ LF+ +   VK  + F     KMAL+++ SVE AIE LI+LH++DL G N  LRVSFSK
Sbjct:   34 ANGNDSKKFKGDLRGPNVPSRVLHIRKLPIDITETEVISLGLPFGDVTNLLMLKAKNQAFLEMNSEEAAQNMVGYYSTVMPIIRQQPVFVQFSNHKELKTDNSPNQERAQAALRALSSSHVDTAALVVAPSSVLRVVVENLLYP-VSLDALCQIFSKFGTVLRIIVFTKNNQFQALLQYAEGASAQAAKVSLDGQNIYNGCCTLRISFSKLTTLNVKYNNDKSRDFTR-PDLPSGDGQPTMEHQAMATAFGPGIISASPYTGATHAF-------PPAFALQPVSSPYAGLTMSGLPGTLASLTLPAGARLGF-------PAIPAGHS----------------VVLVSNLNAECGTIMKRFLTCWCVYGDVMRVKILFNKKENALVQMSDSTQAQLAMSHLNGQRLHGRPLRITLSKHTSV--QLPREGHEDQG----LTKDYSSSPLHRFKKPGSKNYSNIFPPSATLHLSNIPPSVVEDDLKMLFSSSGAVVKAFKFFQKD-HKMALIQMGSVEEAIECLIQLHNHDL-GENHHLRVSFSK 536          

Query:   33 MMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN 1655
            MMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFAT+EHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN
Sbjct:    1 MMKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATEEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN 541          

Query:   36 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN 1655
            MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFAT+EHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN
Sbjct:    1 MKRKLDVKVEEDISDNEENKKIRREIPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATEEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYLN 540          

Query:  120 SKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQSTDSSMHPEAENAVSTTNQICDSMAKEQAGPVLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFSNRQSLDISREDDLVRDFVRHPVSPQELKNI-HVNIGGGIP-------KETERFRDIREFRELRD----PIDTLAALQPLLTHAATHPDDAMPLLRSIAPAIRGFLDSQDLLP---REISRHD-RNDNFGRTHFGEKT----SPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSNLRVSFSKQYL 1652
            S+VLH+R++  DVTE +IA++A PFG ISY+VLTRKTGQAL+EM  +E A+ M +YY +  PH   K   IQ+S + TL  + S MHPEAE AV   N+    + + +   VL + +++W   ++ +LH +K+FQ YG + RI+++V     Q  I++    +A VAK    G   F    V R+ FS R+SLDI  E D  RD+   PV   EL +I   N   G+         +   +   R+   + +      + LA LQPLL  A+ +P+D +P+L+S+AP +   L+   +     RE SR +  N+N   T    K+    + ++IV+NLNE +I PDALF LFG YGDV RVKI+YN+KNTALIQF   EHA RA+  LN VNLYGKP+ VNFSKH  IS   P     EE     L+++Y++S+LHRFKRA SR   NIY P  VLH+AGL +   EE+I+ LF D  + + K+++ N + +KMALV+L +++ AI+ALI+LHD D+  S LRVSFSK ++
Sbjct:   25 SRVLHIRNVSSDVTERDIANLAIPFGLISYLVLTRKTGQALMEMHHEESAQAMVDYYSKCLPHFYGKNIVIQFSRYETL--SGSGMHPEAETAVKGANEDVRKLCEGEPKLVLHVTIENWEGSRLGHLHFYKLFQRYGTICRIIVFVQNQSPQALIEFENEVAAHVAKLQLGGSNAFYGRPV-RIEFSTRKSLDIKHESDTGRDYTISPVRKDELNSIPSFNSSYGMDDHGNANYSQHHDYPVSRQGGSMNNGQMTAAEALAMLQPLLQQASNNPNDTLPMLQSLAPTLTSLLNQSQMGSMNSRESSRMNYSNENLNNTSSSRKSQGNANSVVIVANLNEDRISPDALFILFGVYGDVQRVKILYNKKNTALIQFVDGEHAARAVTNLNNVNLYGKPMRVNFSKHTSISMPKP-----EEQNSVHLNKDYSNSRLHRFKRATSRTVQNIYPPGTVLHLAGLPESYEEEEIKNLFDD--YAITKVKMINPNQRKMALVQLETIDMAIDALIKLHDCDVGLSKLRVSFSKGFI 545          

Query:   66 EDISDN---EENKKIRREI----PPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTL--QSTDSSMHPEAENAVSTTNQICDSMAKEQAGP--VLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQELKNIHVN------IGGGIPKETERFRDIREFRELRDPIDTLAA-----LQPLLTHAATHPDDAMPLL--RSIAPAIRGFLDSQDLLPREISRHDRNDNFGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLCGSN-LRVSFSK 1643
            +D S N     +KK++ E      PS+V+H+R++P +V +  +A +A PFG+I  +V  RK  QAL++M     A  M +Y+ ++ P +  K  FIQ+S H  L  ++ +S++    ++A         + A    G   +LR+++D+  +  I +L  +KIF  +G + RIV +       G ++++   S+ VA+   NG  +   C  +R++FS N   L + R+ D VRD++  P++  EL+ +            G      R  D +    +   +  +A+     L P    AA     A   +  R+   +  GF  +Q           +N  F      E  + +++V+NLN  K +PDALF LFG YGDV RVK+M+N+KNTAL+QFA  + A  A++ L+   L+GK +H++ SK + I  + P+  +    T D     Y++S LHRFK+  S+N+ NI+ PS V+H++ +    SE D+  +     + VKK + F  + KKMAL+EL+SVE AI  LIE H+  L   N LR+SFSK
Sbjct:    2 DDFSQNSFDNSHKKVKMEQGIDEKPSRVIHIRNVPQEVDDTSVAMLAVPFGYIDNIVFVRKNNQALIQMRELNEAIEMADYFNQYVPLMYGKHLFIQFSKHQQLDLRNNNSNIDKLVQSANEKRKHYLINWANNTGGASEILRILIDNAPNLIINHLVFYKIFSRFGQIIRIVSFTKNNQHHGLVEFASTLSSHVAQLQLNGANLLGDCGTMRIDFSKNPGPLQVQRQSDKVRDYMESPLNRTELQELEGPQYSFPLFAVGRSMSMARGNDQQFMSNITAQLSAMASQTGVELTPAAAMAAASLMAACNQMNHRTADQSNWGFGSNQS----------QNAMFNPNSGIENGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNLDACFLWGKQMHLHVSKTNVI--QLPMEDANHGLTKD-----YSNSTLHRFKKPNSKNYQNIFPPSAVVHLSNIPPTTSEGDLSDMIRIAGYEVKKFK-FLPNDKKMALLELNSVEDAIHVLIEFHNRKLSEKNHLRISFSK 535          

Query:   78 DNEENKKIRRE----IPPSKVLHVRSLPDDVTEMEIASIATPFGHISYMVLTRKTGQALLEMETKEIAETMFEYYQRHSPHLRNKRCFIQYSHHGTLQ------STDSSMHPEAENAVSTTNQ-ICDSMAKEQAGP--VLRLVVDDWNHEKITNLHLFKIFQHYGILERIVIYVSKGIVQGFIQYSEPFSAKVAKALTNGLCVFPRCCVLRVNFS-NRQSLDISREDDLVRDFVRHPVSPQELKNIHVNIGGGIPKETERFRDIREFRELRDPIDTLAALQ--PLLTHAATHP--DDAMP--LLRSIAPAI--RGFLDSQDLLPREISRHDRNDN--------FGRTHFGEKTSPLLIVSNLNEAKIHPDALFKLFGCYGDVTRVKIMYNRKNTALIQFATDEHAQRALQFLNGVNLYGKPLHVNFSKHDRISHRAPIAGSEEEATGDLLHREYNDSKLHRFKRAQSRNHSNIYEPSKVLHVAGLIDDVSEEDIEALFTDNKFRVKKIRVFNSSGKKMALVELSSVESAIEALIELHDYDLC-GSNLRVSFSK 1643
            D+ E+KK + E      PSKVLH+R++     E +++ +A PFG I  MV  +KT QALLE+E    A  MF+YY R+ P    +   +QYS H +L+      + D+S+  +A N ++  ++ I D  + E      +LR+V+++  +  I +L + K+FQ +G + RI+I+      Q  ++     SA V+    NG  +F  CC L++ FS N  SL I R++D  RD+   P+   E  ++H             F D +       P     +L   PLL      P   D +P  L  ++ P +    F  S   +P  +   D   N           +      S +++VSNLN  K++ D++F LFG YGDV++V I       AL+   T+  A+ A + LN V L+GK +       + ++     +    E   D+  + + ++ LHRFK+  S+NH NIY PS VLH++ +     EED+  LF DN F+   +R+F    KKMAL +++S+E AI ALI LH++ L   S+LRVSFSK
Sbjct:  105 DSNESKKSKLEPSTNTEPSKVLHIRNIASRAQESDLSLLAVPFGKIRSMVYAKKTNQALLELEKASEATRMFDYYTRYPPCFNGREMIVQYSKHVSLELKLKNSNIDASV--DAANKMNEKHRSIVDEWSSENKSDRRILRVVIENLKNYNINHLVILKVFQRFGKVLRIIIFTKNMQCQCLVELDNSISAHVSLLHLNGQDLFNDCCRLKIEFSKNTDSLQIQRQNDKCRDYTVSPLQEDEQFSLH-------------FLDWQAKSVSTVPPQQYPSLSTVPLLQTQVQKPLYSDFLPNNLFYTVMPNVFKSTFQPSPVAIPESLLISDCAINPLYQEPIVKPPSSANAIDSSIILVSNLNYEKVNTDSIFTLFGVYGDVSKVCISPPSVGAALVYMQTNSQAETACRHLNLVPLFGKIISTYLLPGEIVAQ----SIFNTELNSDIEVKHFTNTPLHRFKKPNSKNHFNIYPPSSVLHLSNIPLSFKEEDLLTLFHDNGFQCSSLRIF-QKDKKMALAKMTSLEDAISALISLHNWKLTDSSHLRVSFSK 637