Transcription factor Sox-21

Overview
NameTranscription factor Sox-21
Smed IDSMED30004924
Length (bp)1194
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transcription factor Sox-21 (SMED30004924) t-SNE clustered cells

Violin plots show distribution of expression levels for Transcription factor Sox-21 (SMED30004924) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30004924

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30004924SMESG000052511.1 dd_Smed_v4_36521_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30004924SMESG000052511.1 dd_Smed_v4_36521_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30004924SMESG000052511.1 dd_Smed_v4_36521_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30004924SMESG000052511.1 dd_Smed_v6_36521_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Match: SOX21 (SRY-box transcription factor 21 [Source:HGNC Symbol;Acc:HGNC:11197])

HSP 1 Score: 127.102 bits (318), Expect = 2.549e-33
Identity = 66/91 (72.53%), Postives = 72/91 (79.12%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYE 536
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K       G  L G  + E
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYG--LGGVADAE 107
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Match: SOX14 (SRY-box transcription factor 14 [Source:HGNC Symbol;Acc:HGNC:11193])

HSP 1 Score: 121.324 bits (303), Expect = 1.547e-31
Identity = 55/67 (82.09%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK++
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDR 91

HSP 2 Score: 49.2914 bits (116), Expect = 4.544e-6
Identity = 21/40 (52.50%), Postives = 28/40 (70.00%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    7 HIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Match: SOX2 (SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195])

HSP 1 Score: 122.479 bits (306), Expect = 3.831e-31
Identity = 56/70 (80.00%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K  +
Sbjct:   58 KMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 127
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Match: SOX1 (SRY-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11189])

HSP 1 Score: 111.309 bits (277), Expect = 1.287e-26
Identity = 48/57 (84.21%), Postives = 56/57 (98.25%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRR 452
            KMAQ NPKMHNSEISKRLG+EWK++++++KRPFIDEAKRLRA+HMKEHPDYKYRPRR
Sbjct:   68 KMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRR 124
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Match: SOX3 (SRY-box transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11199])

HSP 1 Score: 110.538 bits (275), Expect = 4.447e-26
Identity = 49/57 (85.96%), Postives = 55/57 (96.49%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRR 452
            KMA  NPKMHNSEISKRLG++WKLLTD++KRPFIDEAKRLRA+HMKE+PDYKYRPRR
Sbjct:  156 KMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRR 212
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Match: sox-3 (SOX (Mammalian SRY box) family [Source:UniProtKB/TrEMBL;Acc:Q20201])

HSP 1 Score: 119.398 bits (298), Expect = 1.584e-31
Identity = 55/74 (74.32%), Postives = 64/74 (86.49%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATM 503
            KMAQ NPKMHNSEISKRLG+EWK L++ +KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK    K++ ++N  M
Sbjct:   65 KMAQDNPKMHNSEISKRLGAEWKQLSEQEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKSSNLKQQPRLNIAM 138

HSP 2 Score: 50.0618 bits (118), Expect = 5.939e-7
Identity = 22/40 (55.00%), Postives = 28/40 (70.00%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            HVKRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:   47 HVKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEW 86
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 115.931 bits (289), Expect = 1.818e-29
Identity = 54/71 (76.06%), Postives = 61/71 (85.92%), Query Frame = 3 
Query:  279 EKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            +KMA  NPKMHNSEISKRLG+EWK+L++ +KRPFIDEAKRLRAIHMKEHPDYKYRPRRK K + KK    I
Sbjct:   76 KKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPI 146

HSP 2 Score: 48.521 bits (114), Expect = 4.163e-6
Identity = 22/39 (56.41%), Postives = 27/39 (69.23%), Query Frame = 1 
Query:  232 VKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            VKRPMNAFMVWSRGQRKK     PK+    I+++   +W
Sbjct:   60 VKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEW 98
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 115.931 bits (289), Expect = 1.818e-29
Identity = 54/71 (76.06%), Postives = 61/71 (85.92%), Query Frame = 3 
Query:  279 EKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            +KMA  NPKMHNSEISKRLG+EWK+L++ +KRPFIDEAKRLRAIHMKEHPDYKYRPRRK K + KK    I
Sbjct:   76 KKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPI 146

HSP 2 Score: 48.521 bits (114), Expect = 4.163e-6
Identity = 22/39 (56.41%), Postives = 27/39 (69.23%), Query Frame = 1 
Query:  232 VKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            VKRPMNAFMVWSRGQRKK     PK+    I+++   +W
Sbjct:   60 VKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEW 98
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 115.931 bits (289), Expect = 1.818e-29
Identity = 54/71 (76.06%), Postives = 61/71 (85.92%), Query Frame = 3 
Query:  279 EKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            +KMA  NPKMHNSEISKRLG+EWK+L++ +KRPFIDEAKRLRAIHMKEHPDYKYRPRRK K + KK    I
Sbjct:   76 KKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPI 146

HSP 2 Score: 48.521 bits (114), Expect = 4.163e-6
Identity = 22/39 (56.41%), Postives = 27/39 (69.23%), Query Frame = 1 
Query:  232 VKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            VKRPMNAFMVWSRGQRKK     PK+    I+++   +W
Sbjct:   60 VKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEW 98
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Match: sox-2 (Transcription factor sox-2 [Source:UniProtKB/Swiss-Prot;Acc:Q21305])

HSP 1 Score: 106.301 bits (264), Expect = 7.335e-27
Identity = 48/62 (77.42%), Postives = 54/62 (87.10%), Query Frame = 3 
Query:  306 MHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            MHNSEISKRLG+EWK+L++ +KRPFIDEAKRLRAIHMKEHPDYKYRPRRK K + KK    I
Sbjct:    1 MHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPI 62
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Match: Sox21a (gene:FBgn0036411 transcript:FBtr0330178)

HSP 1 Score: 124.02 bits (310), Expect = 2.045e-31
Identity = 57/64 (89.06%), Postives = 60/64 (93.75%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYK 473
            KMAQ NPKMHNSEISKRLG+EWKLLT+ QKRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L K
Sbjct:  138 KMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNK 201
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Match: Sox21a (gene:FBgn0036411 transcript:FBtr0075748)

HSP 1 Score: 123.635 bits (309), Expect = 2.129e-31
Identity = 57/64 (89.06%), Postives = 60/64 (93.75%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYK 473
            KMAQ NPKMHNSEISKRLG+EWKLLT+ QKRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L K
Sbjct:  138 KMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNK 201
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Match: Sox21b (gene:FBgn0042630 transcript:FBtr0075747)

HSP 1 Score: 120.168 bits (300), Expect = 2.349e-29
Identity = 54/62 (87.10%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQL 467
            K+AQ NPKMHNSEISKRLG+EWKLLT+ +KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L
Sbjct:  265 KIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKAL 326
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Match: Sox21b (gene:FBgn0042630 transcript:FBtr0330115)

HSP 1 Score: 120.168 bits (300), Expect = 2.349e-29
Identity = 54/62 (87.10%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQL 467
            K+AQ NPKMHNSEISKRLG+EWKLLT+ +KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L
Sbjct:  265 KIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKAL 326
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Match: Sox21b (gene:FBgn0042630 transcript:FBtr0330116)

HSP 1 Score: 120.168 bits (300), Expect = 2.524e-29
Identity = 54/62 (87.10%), Postives = 59/62 (95.16%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQL 467
            K+AQ NPKMHNSEISKRLG+EWKLLT+ +KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L
Sbjct:  265 KIAQDNPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKAL 326
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Match: sox21a (SRY-box transcription factor 21a [Source:NCBI gene;Acc:30543])

HSP 1 Score: 127.872 bits (320), Expect = 3.125e-34
Identity = 59/73 (80.82%), Postives = 64/73 (87.67%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINAT 500
            KMA  NPKMHNSEISKRLG EWKLL+DS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK++   N T
Sbjct:   25 KMALDNPKMHNSEISKRLGGEWKLLSDSEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKPKNLIKKDRYHFNVT 97
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Match: sox21a (SRY-box transcription factor 21a [Source:NCBI gene;Acc:30543])

HSP 1 Score: 127.872 bits (320), Expect = 3.125e-34
Identity = 59/73 (80.82%), Postives = 64/73 (87.67%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINAT 500
            KMA  NPKMHNSEISKRLG EWKLL+DS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK++   N T
Sbjct:   25 KMALDNPKMHNSEISKRLGGEWKLLSDSEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKPKNLIKKDRYHFNVT 97
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Match: sox21b (SRY-box transcription factor 21b [Source:NCBI gene;Acc:406246])

HSP 1 Score: 127.487 bits (319), Expect = 5.682e-34
Identity = 62/76 (81.58%), Postives = 67/76 (88.16%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K   
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLMKKDKFAF 94
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Match: sox14 (SRY-box transcription factor 14 [Source:NCBI gene;Acc:557661])

HSP 1 Score: 122.094 bits (305), Expect = 5.307e-32
Identity = 56/67 (83.58%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++S+KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK++
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDR 91

HSP 2 Score: 49.2914 bits (116), Expect = 2.667e-6
Identity = 21/40 (52.50%), Postives = 28/40 (70.00%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    7 HIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 124.02 bits (310), Expect = 6.275e-32
Identity = 57/70 (81.43%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWKLL++S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K  +
Sbjct:   55 KMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 124
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Match: gsr (glutathione reductase [Source:Xenbase;Acc:XB-GENE-997099])

HSP 1 Score: 127.487 bits (319), Expect = 1.477e-33
Identity = 64/89 (71.91%), Postives = 73/89 (82.02%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHN 530
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+++KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K       G   +G+H+
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPMPYG--FTGDHD 105
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Match: spag16 (sperm associated antigen 16 [Source:Xenbase;Acc:XB-GENE-949128])

HSP 1 Score: 120.939 bits (302), Expect = 1.717e-31
Identity = 55/67 (82.09%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK++
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDR 91

HSP 2 Score: 50.0618 bits (118), Expect = 1.904e-6
Identity = 22/42 (52.38%), Postives = 29/42 (69.05%), Query Frame = 1 
Query:  223 VTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            V H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    5 VDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Match: sox2 (SRY-box 2 [Source:NCBI gene;Acc:407873])

HSP 1 Score: 122.865 bits (307), Expect = 1.866e-31
Identity = 56/70 (80.00%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K  +
Sbjct:   54 KMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 123
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Match: sox3 (SRY-box 3 [Source:NCBI gene;Acc:493228])

HSP 1 Score: 113.62 bits (283), Expect = 4.174e-28
Identity = 50/57 (87.72%), Postives = 56/57 (98.25%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRR 452
            KMAQ NPKMHNSEISKRLG++WKLL+DS+KRPFIDEAKRLRA+HMKE+PDYKYRPRR
Sbjct:   57 KMAQENPKMHNSEISKRLGADWKLLSDSEKRPFIDEAKRLRAVHMKEYPDYKYRPRR 113
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Match: smad9 (SMAD family member 9 [Source:Xenbase;Acc:XB-GENE-484686])

HSP 1 Score: 88.1965 bits (217), Expect = 9.687e-23
Identity = 39/60 (65.00%), Postives = 49/60 (81.67%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPK 461
            K+ + +P MHN+EISKRLG  WK+L DS+K PFI EA+RLR  HM ++PDYKYRPR+KPK
Sbjct:   65 KIMEQSPDMHNAEISKRLGKRWKMLNDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPK 124

HSP 2 Score: 38.891 bits (89), Expect = 9.687e-23
Identity = 14/19 (73.68%), Postives = 18/19 (94.74%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKK 285
            H+KRPMNAFMVWS+ +R+K
Sbjct:   47 HIKRPMNAFMVWSKIERRK 65
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Match: Sox21 (SRY (sex determining region Y)-box 21 [Source:MGI Symbol;Acc:MGI:2654070])

HSP 1 Score: 127.872 bits (320), Expect = 8.494e-34
Identity = 65/90 (72.22%), Postives = 72/90 (80.00%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQ--INATMGSFLSGNH 527
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K    +   +GS     H
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGSVADAEH 108
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Match: Sox14 (SRY (sex determining region Y)-box 14 [Source:MGI Symbol;Acc:MGI:98362])

HSP 1 Score: 121.709 bits (304), Expect = 1.377e-32
Identity = 57/75 (76.00%), Postives = 64/75 (85.33%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMG 506
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK+       MG
Sbjct:   16 KMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDSSSAIQKMG 90
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Match: Sox14 (SRY (sex determining region Y)-box 14 [Source:MGI Symbol;Acc:MGI:98362])

HSP 1 Score: 121.324 bits (303), Expect = 1.051e-31
Identity = 55/67 (82.09%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK++
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDR 91

HSP 2 Score: 49.2914 bits (116), Expect = 3.007e-6
Identity = 21/40 (52.50%), Postives = 28/40 (70.00%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    7 HIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Match: Sox2 (SRY (sex determining region Y)-box 2 [Source:MGI Symbol;Acc:MGI:98364])

HSP 1 Score: 122.479 bits (306), Expect = 2.210e-31
Identity = 56/70 (80.00%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWKLL++++KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K  +
Sbjct:   60 KMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 129
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Match: Sox15 (SRY (sex determining region Y)-box 15 [Source:MGI Symbol;Acc:MGI:98363])

HSP 1 Score: 109.383 bits (272), Expect = 2.742e-27
Identity = 53/110 (48.18%), Postives = 69/110 (62.73%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLP 611
            +MAQ NPKMHNSEISKRLG++WKLL D +KRPF++EAKRLRA H++++PDYKYRPRRK K       +  +   G    G  ++      + GS    Y  P+     LP
Sbjct:   64 QMAQQNPKMHNSEISKRLGAQWKLLGDEEKRPFVEEAKRLRARHLRDYPDYKYRPRRKSKN-SSTGSVPFSQEGGGLACGGSHWGPGYTTTQGSRGFGYQPPNYSTAYLP 172
[Close]
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Match: sp|Q7SZS1|SX21A_DANRE (Transcription factor Sox-21-A OS=Danio rerio OX=7955 GN=sox21a PE=2 SV=1)

HSP 1 Score: 128.257 bits (321), Expect = 1.727e-33
Identity = 62/79 (78.48%), Postives = 67/79 (84.81%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINAT 500
            SRA   KMA  NPKMHNSEISKRLG EWKLL+DS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK++   N T
Sbjct:   19 SRAQRRKMALDNPKMHNSEISKRLGGEWKLLSDSEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKPKNLIKKDRYHFNVT 97
[Close]
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Match: sp|Q6RVD7|SX21B_DANRE (Transcription factor Sox-21-B OS=Danio rerio OX=7955 GN=sox21b PE=2 SV=1)

HSP 1 Score: 127.487 bits (319), Expect = 4.289e-33
Identity = 62/76 (81.58%), Postives = 67/76 (88.16%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K   
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLMKKDKFAF 94
[Close]
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Match: sp|Q811W0|SOX21_MOUSE (Transcription factor SOX-21 OS=Mus musculus OX=10090 GN=Sox21 PE=2 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 5.942e-33
Identity = 65/90 (72.22%), Postives = 72/90 (80.00%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQ--INATMGSFLSGNH 527
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K    +   +GS     H
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGSVADAEH 108
[Close]
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Match: sp|Q9Y651|SOX21_HUMAN (Transcription factor SOX-21 OS=Homo sapiens OX=9606 GN=SOX21 PE=2 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 1.224e-32
Identity = 66/91 (72.53%), Postives = 72/91 (79.12%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYE 536
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K       G  L G  + E
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYG--LGGVADAE 107
[Close]
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Match: sp|B0ZTE1|SOX21_XENLA (Transcription factor Sox-21 OS=Xenopus laevis OX=8355 GN=sox21 PE=2 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 1.289e-32
Identity = 64/89 (71.91%), Postives = 74/89 (83.15%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHN 530
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+++KRPFIDEAKRLRA+HMK+HPDYKYRPRRKPK L KK+K      M   L+G+H+
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRAMHMKDHPDYKYRPRRKPKTLLKKDKFAF--PMPYSLTGDHD 105
[Close]
BLAST of Transcription factor Sox-21 vs. TrEMBL
Match: A0A0A7M2A4 (SOXB2-1 (Fragment) OS=Schmidtea polychroa OX=50054 GN=soxb2-1 PE=2 SV=1)

HSP 1 Score: 383.645 bits (984), Expect = 1.136e-129
Identity = 185/187 (98.93%), Postives = 187/187 (100.00%), Query Frame = 3 
Query:  279 EKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPI 839
            +K+AQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPI
Sbjct:  102 KKVAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPI 288

HSP 2 Score: 149.828 bits (377), Expect = 1.294e-38
Identity = 83/116 (71.55%), Postives = 94/116 (81.03%), Query Frame = 1 
Query:    1 SVDNLEDEESIDRCKSEQTFCTDSVDTYVXXXXXXXXXXXXXXXVKLTEKTDELISSVELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            SVDNLEDEESIDRCKSEQTFCT+SVDTYVDIED++  +  D    KLTEK+D LI S ELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKK     PK+    I+++  ++W
Sbjct:   12 SVDNLEDEESIDRCKSEQTFCTNSVDTYVDIEDDDEIEKIDE---KLTEKSDNLIGSTELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKVAQINPKMHNSEISKRLGSEW 124
[Close]
BLAST of Transcription factor Sox-21 vs. TrEMBL
Match: A0A2D0R6L5 (transcription factor Sox-21-B-like OS=Ictalurus punctatus OX=7998 GN=LOC108266914 PE=4 SV=1)

HSP 1 Score: 130.568 bits (327), Expect = 8.240e-32
Identity = 64/86 (74.42%), Postives = 71/86 (82.56%), Query Frame = 3 
Query:  252 VYGLESRATEK-MAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMG 506
             + + SRA  + MAQ NPKMHNSEISKRLG+EWKLLTDS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KKEK  +    G
Sbjct:   14 AFMVWSRAQRRQMAQENPKMHNSEISKRLGAEWKLLTDSEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLAKKEKFALALPYG 99
[Close]
BLAST of Transcription factor Sox-21 vs. TrEMBL
Match: A0A1I8Q1U3 (HMG box domain-containing protein OS=Stomoxys calcitrans OX=35570 GN=106093384 PE=4 SV=1)

HSP 1 Score: 131.724 bits (330), Expect = 1.419e-31
Identity = 77/141 (54.61%), Postives = 91/141 (64.54%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSG--------SSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRS 680
            KMAQ NPKMHNSEISKRLG+EWKLLT+++KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L K      N++ G+   G  ++E N+  S+         SSH S L  +          SP EL+ N    LSN  P S
Sbjct:   85 KMAQDNPKMHNSEISKRLGAEWKLLTETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPIPATNSSNGNG-GGQAHHESNVNGSNNHSLHNHQRSSHQSSLTSTTLAGHKYNFGSPLELTLNMPPRLSNTFPAS 224
[Close]
BLAST of Transcription factor Sox-21 vs. TrEMBL
Match: A0A2I0MSF1 (SRY (Sex determining region Y)-box 21 OS=Columba livia OX=8932 GN=SOX21 PE=4 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 1.421e-31
Identity = 63/87 (72.41%), Postives = 70/87 (80.46%), Query Frame = 3 
Query:  252 VYGLESRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGS 509
             + + SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K       G 
Sbjct:    3 AFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGG 89
[Close]
BLAST of Transcription factor Sox-21 vs. TrEMBL
Match: A0A4W4ENI8 (HMG box domain-containing protein OS=Electrophorus electricus OX=8005 GN=SOX21 (1 of many) PE=4 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 1.735e-31
Identity = 67/100 (67.00%), Postives = 76/100 (76.00%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGS 563
            SRA   KMA  NPKMHNSEISKRLG EWKLL+DS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK   KK++ Q N    S+  G+H+  K  L   G+
Sbjct:   19 SRAQRRKMALDNPKMHNSEISKRLGGEWKLLSDSEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKPKNSMKKDRYQFNV---SYNLGDHDSLKGALLPGGA 115
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Match: sox21b (SRY-box transcription factor 21b [Source:NCBI gene;Acc:406246])

HSP 1 Score: 127.872 bits (320), Expect = 2.332e-34
Identity = 77/143 (53.85%), Postives = 92/143 (64.34%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKE----------------KIQINATMGSFLSGNHNYEKNLLASSGSSH-MSYL-----LPSIRPTRLPFASSP 626
            SRA   KMAQ NPKMHNSEISKRLG+EWKLLT+++KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KKE                 +++ A +GSF S      +  L  S  +H  S+L     +P +    LP+AS P
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLLKKEGKFAFPVPYGLAEHEAALKVGAGLGSFPSA--ALSEVFLNPSIPAHPYSFLELGSKMPELSTPSLPYASPP 159
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Match: sox21a (SRY-box transcription factor 21 [Source:NCBI gene;Acc:103039893])

HSP 1 Score: 125.946 bits (315), Expect = 1.623e-33
Identity = 63/96 (65.62%), Postives = 72/96 (75.00%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATM---------GSFLSGN 524
            SRA   KMA  NPKMHNSEISKRLG EWKLL+DS+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK   +K++ Q+N            G+ L G+
Sbjct:   19 SRAQRRKMALDNPKMHNSEISKRLGGEWKLLSDSEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKPKNAARKDRYQLNVAYSLGEPDSLKGALLQGD 114

HSP 2 Score: 48.1358 bits (113), Expect = 5.892e-6
Identity = 21/43 (48.84%), Postives = 28/43 (65.12%), Query Frame = 1 
Query:  220 KVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
             + HVKRPMNAFMVWSR QR+K     PK+    I+++   +W
Sbjct:    4 PIDHVKRPMNAFMVWSRAQRRKMALDNPKMHNSEISKRLGGEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Match: ENSAMXT00000004288.2 (pep primary_assembly:Astyanax_mexicanus-2.0:13:15067225:15068019:-1 gene:ENSAMXG00000004192.2 transcript:ENSAMXT00000004288.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 124.02 bits (310), Expect = 5.566e-33
Identity = 58/67 (86.57%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLLT+S+KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KKE+
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLTESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKER 91

HSP 2 Score: 50.0618 bits (118), Expect = 1.136e-6
Identity = 22/42 (52.38%), Postives = 29/42 (69.05%), Query Frame = 1 
Query:  223 VTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            V H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    5 VDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 122.479 bits (306), Expect = 4.938e-32
Identity = 57/67 (85.07%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K
Sbjct:   56 KMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDK 122
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Match: sox19b (transcription factor Sox-19b [Source:NCBI gene;Acc:103045346])

HSP 1 Score: 119.783 bits (299), Expect = 9.537e-31
Identity = 59/83 (71.08%), Postives = 67/83 (80.72%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKE----KIQINATMGSFLS 518
            KMAQ NPKMHNSEISKRLG+EWKLLTD++KRPFIDEAKRLRA+HMKE+PDYKY+PRRK K L KK+    K  +    G  LS
Sbjct:   71 KMAQENPKMHNSEISKRLGAEWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYKPRRKTKPLLKKDAPPGKYPLTTAQGQALS 153
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Match: sox1b (SRY-box transcription factor 1b [Source:NCBI gene;Acc:562710])

HSP 1 Score: 118.627 bits (296), Expect = 4.196e-30
Identity = 51/57 (89.47%), Postives = 56/57 (98.25%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRR 452
            KMAQ NPKMHNSEISKRLG+EWKLLT+++KRPFIDEAKRLRA+HMKEHPDYKYRPRR
Sbjct:   76 KMAQENPKMHNSEISKRLGAEWKLLTEAEKRPFIDEAKRLRALHMKEHPDYKYRPRR 132

HSP 2 Score: 48.521 bits (114), Expect = 1.718e-6
Identity = 21/39 (53.85%), Postives = 27/39 (69.23%), Query Frame = 1 
Query:  232 VKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            VKRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:   59 VKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 97
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Match: sox4b (SRY-box transcription factor 4b [Source:ZFIN;Acc:ZDB-GENE-040426-1274])

HSP 1 Score: 82.0333 bits (201), Expect = 1.057e-21
Identity = 37/60 (61.67%), Postives = 47/60 (78.33%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPK 461
            K+ + +P MHN+EISKRLG  WK L +S+K PFI EA+RLR  HM ++PDYKYRPR+K K
Sbjct:   79 KIMEQSPDMHNAEISKRLGRRWKQLKESEKVPFIREAERLRLKHMADYPDYKYRPRKKAK 138

HSP 2 Score: 38.1206 bits (87), Expect = 1.057e-21
Identity = 14/19 (73.68%), Postives = 18/19 (94.74%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKK 285
            H+KRPMNAFMVWS+ +R+K
Sbjct:   61 HIKRPMNAFMVWSQIERRK 79
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010223.1 (pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 gene:ENSPMAG00000009255.1 transcript:ENSPMAT00000010223.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 79.337 bits (194), Expect = 1.127e-18
Identity = 36/64 (56.25%), Postives = 50/64 (78.12%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRK--PKQL 467
            ++A+ NP +HN+E+SK LG  W+ LT   +RP ++EA+RLR +H+ EHPDYKYRPRRK  PK+L
Sbjct:   23 RLAKQNPDLHNAELSKMLGKSWRALTPESRRPCVEEAERLRLLHLSEHPDYKYRPRRKKQPKRL 86
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Match: sox10 (SRY-box transcription factor 10 [Source:ZFIN;Acc:ZDB-GENE-011207-1])

HSP 1 Score: 83.1889 bits (204), Expect = 4.450e-18
Identity = 37/76 (48.68%), Postives = 54/76 (71.05%), Query Frame = 3 
Query:  273 ATEKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINAT 500
            A  K++   P++HN+E+SK LG  W+LL + +KRPF++EA+RLR  H K+HPDYKY+PRR+ KQ  K +    N+ 
Sbjct:  126 ARRKLSDQYPQLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRMQHKKDHPDYKYQPRRR-KQQGKGDGADTNSA 200
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Match: sox12 (SRY-box transcription factor 12 [Source:ZFIN;Acc:ZDB-GENE-040724-33])

HSP 1 Score: 78.1814 bits (191), Expect = 3.631e-16
Identity = 35/60 (58.33%), Postives = 45/60 (75.00%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPK 461
            K+   +P +HN+EISKRLG  WK L D +K PF+ EA+RLR  HM ++PDYKYRPR+K K
Sbjct:   77 KIMMESPDVHNAEISKRLGRRWKQLKDCEKVPFMREAERLRLKHMADYPDYKYRPRKKAK 136
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Match: EDO40934 (Predicted protein; Sox family protein B1 [Source:UniProtKB/TrEMBL;Acc:Q3S381])

HSP 1 Score: 121.709 bits (304), Expect = 2.401e-31
Identity = 57/76 (75.00%), Postives = 65/76 (85.53%), Query Frame = 3 
Query:  252 VYGLESRATEKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKE 479
            V+  E R   KMAQ NPKMHNSEISKRLGSEWKLL++ +KRP+IDEA+RLRA+HMKEHPDYKYRPRRK K L KK+
Sbjct:   42 VWSRERR--RKMAQDNPKMHNSEISKRLGSEWKLLSEQEKRPYIDEARRLRAVHMKEHPDYKYRPRRKSKTLLKKD 115
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Match: EDO32666 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUF3])

HSP 1 Score: 112.849 bits (281), Expect = 4.675e-29
Identity = 55/75 (73.33%), Postives = 61/75 (81.33%), Query Frame = 3 
Query:  252 VYGLESRATEKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKK 476
            V+  E R   K+AQ NPKMHNSEISKRLGSEWK L D  K+PF++EAK+LRA HMKEHPDYKYRPRRKPK L KK
Sbjct:   19 VWSREER--RKIAQENPKMHNSEISKRLGSEWKQLADDDKKPFVEEAKKLRAQHMKEHPDYKYRPRRKPKSLLKK 91
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Match: EDO44142 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWK8])

HSP 1 Score: 87.4261 bits (215), Expect = 1.311e-21
Identity = 39/80 (48.75%), Postives = 57/80 (71.25%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSG 521
            ++A  NP++HN+E+SK LG  W+ L  +QKRPF+DEA+RLR  HM+++P+YKYRPRR+ K   +  K    A  GS ++G
Sbjct:   90 RLADANPELHNAELSKMLGLTWRALNSTQKRPFVDEAERLRLQHMQDYPNYKYRPRRR-KHSKRAAKRSTGAAAGSKVNG 168

HSP 2 Score: 33.4982 bits (75), Expect = 1.311e-21
Identity = 11/18 (61.11%), Postives = 17/18 (94.44%), Query Frame = 1 
Query:  232 VKRPMNAFMVWSRGQRKK 285
            +KRPMNAFMVW++ +R++
Sbjct:   73 IKRPMNAFMVWAQVERRR 90
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Match: EDO47688 (Predicted protein; Sox family protein 2 [Source:UniProtKB/TrEMBL;Acc:Q3S383])

HSP 1 Score: 84.7297 bits (208), Expect = 6.570e-19
Identity = 40/77 (51.95%), Postives = 56/77 (72.73%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSF 512
            ++A+  P+M NSEISKRLG EW  LT  +K+P+++EAKRLR +H K+HPDYKY+P+RKPK   K +   +N  M  +
Sbjct:   25 RIAEECPRMLNSEISKRLGLEWNSLTLDEKQPYVEEAKRLRELHKKDHPDYKYQPKRKPKTSPKLKTPGLNPFMHGY 101
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Match: EDO37974 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEA1])

HSP 1 Score: 85.5001 bits (210), Expect = 2.038e-18
Identity = 42/78 (53.85%), Postives = 53/78 (67.95%), Query Frame = 3 
Query:  273 ATEKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMG 506
            A  K+A   P +HN+E+SK LG  WKLL DS+K+PFI+EA+RLR  H +EHPDYKY+PRR      KK+K   N   G
Sbjct:   78 ARRKLADQYPHLHNAELSKTLGKLWKLLNDSEKKPFIEEAERLRIKHKREHPDYKYQPRR------KKQKGNGNGDAG 149
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Match: sox21 (SRY-box transcription factor 21 [Source:NCBI gene;Acc:100304456])

HSP 1 Score: 125.176 bits (313), Expect = 3.867e-33
Identity = 61/76 (80.26%), Postives = 67/76 (88.16%), Query Frame = 3 
Query:  267 SRATE-KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            SRA   KMAQ NPKMHNSEISKRLG+EWKLL++S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRKPK L KK+K   
Sbjct:   19 SRAQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLMKKDKFSF 94
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Match: sox2 (SRY-box transcription factor 2 [Source:NCBI gene;Acc:378723])

HSP 1 Score: 122.094 bits (305), Expect = 4.285e-32
Identity = 57/70 (81.43%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWKLL++S+KRPFIDEAKRLRA+HMKEHPDYKYRPRRK K L KK+K  +
Sbjct:   57 KMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL 126
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Match: sox14 (SRY-box transcription factor 14 [Source:NCBI gene;Acc:100304454])

HSP 1 Score: 122.094 bits (305), Expect = 4.289e-32
Identity = 56/67 (83.58%), Postives = 63/67 (94.03%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK 482
            KMAQ NPKMHNSEISKRLG+EWKLL++S+KRP+IDEAKRLRA HMKEHPDYKYRPRRKPK L KK++
Sbjct:   25 KMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDR 91

HSP 2 Score: 49.2914 bits (116), Expect = 2.225e-6
Identity = 21/40 (52.50%), Postives = 28/40 (70.00%), Query Frame = 1 
Query:  229 HVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    7 HIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Match: ENSORLT00000029054.1 (transcription factor Sox-14-like [Source:NCBI gene;Acc:111949029])

HSP 1 Score: 117.857 bits (294), Expect = 1.145e-30
Identity = 60/109 (55.05%), Postives = 74/109 (67.89%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEK---IQINATMGSFLSGN----HNYEKNLLASSGSSHMSYLLP 587
            KMA+ NPKMHNSEISKRLG+EWK L+DS KRPFIDEAKRLRA H++EHPDYKYRPRRKP+ L ++       +    G    G+     +  +  L +  SS +SYL P
Sbjct:   25 KMARENPKMHNSEISKRLGAEWKTLSDSDKRPFIDEAKRLRAQHLREHPDYKYRPRRKPRALLRRPCPLPAALGEECGEGFCGDPFLLGDKARVFLTAGPSSSLSYLEP 133

HSP 2 Score: 49.2914 bits (116), Expect = 1.984e-6
Identity = 22/43 (51.16%), Postives = 29/43 (67.44%), Query Frame = 1 
Query:  220 KVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
             V H+KRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:    4 PVEHIKRPMNAFMVWSRGQRRKMARENPKMHNSEISKRLGAEW 46
[Close]
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Match: sox19b (transcription factor Sox-19a [Source:NCBI gene;Acc:110017107])

HSP 1 Score: 118.627 bits (296), Expect = 3.289e-30
Identity = 54/66 (81.82%), Postives = 62/66 (93.94%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKE 479
            KMAQ NPKMHNSEISKRLG+EWKLL+D++KRPFIDEAKRLRA+HMKE+PDYKY+PRRK K L KK+
Sbjct:   72 KMAQENPKMHNSEISKRLGAEWKLLSDAEKRPFIDEAKRLRAVHMKEYPDYKYKPRRKTKPLLKKD 137
[Close]
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Match: SMESG000052511.1 (SMESG000052511.1)

HSP 1 Score: 485.723 bits (1249), Expect = 2.056e-172
Identity = 259/260 (99.62%), Postives = 260/260 (100.00%), Query Frame = 3 
Query:  279 EKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPIQPYNSISNKLGFPTDPCKIYHSESVESKLXXXXXXXXXXXXXXXXXXXXXTSATWQQTVEALFESLRRKEPQN 1058
            +KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPIQPYNSISNKLGFPTDPCKIYHSESVESKLNQNNNNNNISNNNNNINNNNNTSATWQQTVEALFESLRRKEPQN
Sbjct:   96 KKMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLLPSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKTPTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPIQPYNSISNKLGFPTDPCKIYHSESVESKLNQNNNNNNISNNNNNINNNNNTSATWQQTVEALFESLRRKEPQN 355

HSP 2 Score: 165.622 bits (418), Expect = 1.970e-47
Identity = 97/116 (83.62%), Postives = 104/116 (89.66%), Query Frame = 1 
Query:    1 SVDNLEDEESIDRCKSEQTFCTDSVDTYVXXXXXXXXXXXXXXXVKLTEKTDELISSVELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            SVDNLEDEESIDRCKSEQTFCTDSVDTYVDIEDEEIEKIDD I+VKLTEKTDELISSVELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKK     PK+    I+++  ++W
Sbjct:    3 SVDNLEDEESIDRCKSEQTFCTDSVDTYVDIEDEEIEKIDDEINVKLTEKTDELISSVELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKMAQINPKMHNSEISKRLGSEW 118
[Close]
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Match: SMESG000077970.1 (SMESG000077970.1)

HSP 1 Score: 123.25 bits (308), Expect = 1.149e-31
Identity = 57/70 (81.43%), Postives = 64/70 (91.43%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQI 491
            KMAQ NPKMHNSEISKRLG+EWK LT+ QKRPFIDEAKRLRAIHMK+HPDYKYRPRRKPK +++K+K  I
Sbjct:   86 KMAQENPKMHNSEISKRLGAEWKHLTELQKRPFIDEAKRLRAIHMKDHPDYKYRPRRKPKSIFRKDKYTI 155

HSP 2 Score: 50.0618 bits (118), Expect = 1.529e-6
Identity = 23/44 (52.27%), Postives = 30/44 (68.18%), Query Frame = 1 
Query:  217 MKVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
            +K  HVKRPMNAFMVWSRGQR+K     PK+    I+++   +W
Sbjct:   64 IKEDHVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEW 107
[Close]
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Match: SMESG000011244.1 (SMESG000011244.1)

HSP 1 Score: 110.153 bits (274), Expect = 4.227e-26
Identity = 63/140 (45.00%), Postives = 85/140 (60.71%), Query Frame = 3 
Query:  234 QASDERV------YGLESRATEK-MAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNL-LASSGSSHMSYLLPSIRPTRLPFASSPW 629
            Q  D+RV      + + SR   + MAQ NPKMHNSEISKRLG  WK L++  K+PFIDEAKRLRA HM ++PDYKYRPRRK K + K++K   +A M +  + +H   + +   +SG+S   YL            S+P+
Sbjct:  251 QKKDDRVKRPMNAFMVWSRGQRRRMAQDNPKMHNSEISKRLGGMWKNLSEEDKKPFIDEAKRLRANHMTQYPDYKYRPRRKHKAMDKQKKFLGSAAMANVTALSHQLGREMGYFNSGASGNGYLASGYASLAHSIDSTPY 390
[Close]
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Match: SMESG000011244.1 (SMESG000011244.1)

HSP 1 Score: 110.153 bits (274), Expect = 5.083e-26
Identity = 63/140 (45.00%), Postives = 85/140 (60.71%), Query Frame = 3 
Query:  234 QASDERV------YGLESRATEK-MAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNL-LASSGSSHMSYLLPSIRPTRLPFASSPW 629
            Q  D+RV      + + SR   + MAQ NPKMHNSEISKRLG  WK L++  K+PFIDEAKRLRA HM ++PDYKYRPRRK K + K++K   +A M +  + +H   + +   +SG+S   YL            S+P+
Sbjct:  250 QKKDDRVKRPMNAFMVWSRGQRRRMAQDNPKMHNSEISKRLGGMWKNLSEEDKKPFIDEAKRLRANHMTQYPDYKYRPRRKHKAMDKQKKFLGSAAMANVTALSHQLGREMGYFNSGASGNGYLASGYASLAHSIDSTPY 389
[Close]
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Match: SMESG000067682.1 (SMESG000067682.1)

HSP 1 Score: 100.908 bits (250), Expect = 6.159e-23
Identity = 47/60 (78.33%), Postives = 51/60 (85.00%), Query Frame = 3 
Query:  282 KMAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDYKYRPRRKPK 461
            KM+  NPKMHNSEISKRLGS WK L++  K+PFIDEAKRLRA H KEHPDYKYRPRRK K
Sbjct:  240 KMSVENPKMHNSEISKRLGSMWKSLSEIDKKPFIDEAKRLRANHQKEHPDYKYRPRRKSK 299

HSP 2 Score: 52.373 bits (124), Expect = 4.103e-7
Identity = 24/56 (42.86%), Postives = 34/56 (60.71%), Query Frame = 1 
Query:  181 CQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKW----PKLIRKCITRKSANDW 336
             Q+N N  K  + K   ++RPMNAFMVWSRGQR+K     PK+    I+++  + W
Sbjct:  206 IQINQNANKQTDKKEARIRRPMNAFMVWSRGQRRKMSVENPKMHNSEISKRLGSMW 261
The following BLAST results are available for this feature:
BLAST of Transcription factor Sox-21 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SOX212.549e-3372.53SRY-box transcription factor 21 [Source:HGNC Symbo... [more]
SOX141.547e-3182.09SRY-box transcription factor 14 [Source:HGNC Symbo... [more]
SOX23.831e-3180.00SRY-box transcription factor 2 [Source:HGNC Symbol... [more]
SOX11.287e-2684.21SRY-box transcription factor 1 [Source:HGNC Symbol... [more]
SOX34.447e-2685.96SRY-box transcription factor 3 [Source:HGNC Symbol... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox-31.584e-3174.32SOX (Mammalian SRY box) family [Source:UniProtKB/... [more]
sox-21.818e-2976.06Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-21.818e-2976.06Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-21.818e-2976.06Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
sox-27.335e-2777.42Transcription factor sox-2 [Source:UniProtKB/Swis... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sox21a2.045e-3189.06gene:FBgn0036411 transcript:FBtr0330178[more]
Sox21a2.129e-3189.06gene:FBgn0036411 transcript:FBtr0075748[more]
Sox21b2.349e-2987.10gene:FBgn0042630 transcript:FBtr0075747[more]
Sox21b2.349e-2987.10gene:FBgn0042630 transcript:FBtr0330115[more]
Sox21b2.524e-2987.10gene:FBgn0042630 transcript:FBtr0330116[more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox21a3.125e-3480.82SRY-box transcription factor 21a [Source:NCBI gene... [more]
sox21a3.125e-3480.82SRY-box transcription factor 21a [Source:NCBI gene... [more]
sox21b5.682e-3481.58SRY-box transcription factor 21b [Source:NCBI gene... [more]
sox145.307e-3283.58SRY-box transcription factor 14 [Source:NCBI gene;... [more]
sox26.275e-3281.43SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gsr1.477e-3371.91glutathione reductase [Source:Xenbase;Acc:XB-GENE-... [more]
spag161.717e-3182.09sperm associated antigen 16 [Source:Xenbase;Acc:XB... [more]
sox21.866e-3180.00SRY-box 2 [Source:NCBI gene;Acc:407873][more]
sox34.174e-2887.72SRY-box 3 [Source:NCBI gene;Acc:493228][more]
smad99.687e-2365.00SMAD family member 9 [Source:Xenbase;Acc:XB-GENE-4... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sox218.494e-3472.22SRY (sex determining region Y)-box 21 [Source:MGI ... [more]
Sox141.377e-3276.00SRY (sex determining region Y)-box 14 [Source:MGI ... [more]
Sox141.051e-3182.09SRY (sex determining region Y)-box 14 [Source:MGI ... [more]
Sox22.210e-3180.00SRY (sex determining region Y)-box 2 [Source:MGI S... [more]
Sox152.742e-2748.18SRY (sex determining region Y)-box 15 [Source:MGI ... [more]
back to top
BLAST of Transcription factor Sox-21 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q7SZS1|SX21A_DANRE1.727e-3378.48Transcription factor Sox-21-A OS=Danio rerio OX=79... [more]
sp|Q6RVD7|SX21B_DANRE4.289e-3381.58Transcription factor Sox-21-B OS=Danio rerio OX=79... [more]
sp|Q811W0|SOX21_MOUSE5.942e-3372.22Transcription factor SOX-21 OS=Mus musculus OX=100... [more]
sp|Q9Y651|SOX21_HUMAN1.224e-3272.53Transcription factor SOX-21 OS=Homo sapiens OX=960... [more]
sp|B0ZTE1|SOX21_XENLA1.289e-3271.91Transcription factor Sox-21 OS=Xenopus laevis OX=8... [more]
back to top
BLAST of Transcription factor Sox-21 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0A7M2A41.136e-12998.93SOXB2-1 (Fragment) OS=Schmidtea polychroa OX=50054... [more]
A0A2D0R6L58.240e-3274.42transcription factor Sox-21-B-like OS=Ictalurus pu... [more]
A0A1I8Q1U31.419e-3154.61HMG box domain-containing protein OS=Stomoxys calc... [more]
A0A2I0MSF11.421e-3172.41SRY (Sex determining region Y)-box 21 OS=Columba l... [more]
A0A4W4ENI81.735e-3167.00HMG box domain-containing protein OS=Electrophorus... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox21b2.332e-3453.85SRY-box transcription factor 21b [Source:NCBI gene... [more]
sox21a1.623e-3365.63SRY-box transcription factor 21 [Source:NCBI gene;... [more]
ENSAMXT00000004288.25.566e-3386.57pep primary_assembly:Astyanax_mexicanus-2.0:13:150... [more]
sox24.938e-3285.07SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
sox19b9.537e-3171.08transcription factor Sox-19b [Source:NCBI gene;Acc... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox1b4.196e-3089.47SRY-box transcription factor 1b [Source:NCBI gene;... [more]
sox4b1.057e-2161.67SRY-box transcription factor 4b [Source:ZFIN;Acc:Z... [more]
ENSPMAT00000010223.11.127e-1856.25pep scaffold:Pmarinus_7.0:GL478813:2555:9375:-1 ge... [more]
sox104.450e-1848.68SRY-box transcription factor 10 [Source:ZFIN;Acc:Z... [more]
sox123.631e-1658.33SRY-box transcription factor 12 [Source:ZFIN;Acc:Z... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO409342.401e-3175.00Predicted protein; Sox family protein B1 [Source:... [more]
EDO326664.675e-2973.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO441421.311e-2148.75Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476886.570e-1951.95Predicted protein; Sox family protein 2 [Source:U... [more]
EDO379742.038e-1853.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sox213.867e-3380.26SRY-box transcription factor 21 [Source:NCBI gene;... [more]
sox24.285e-3281.43SRY-box transcription factor 2 [Source:NCBI gene;A... [more]
sox144.289e-3283.58SRY-box transcription factor 14 [Source:NCBI gene;... [more]
ENSORLT00000029054.11.145e-3055.05transcription factor Sox-14-like [Source:NCBI gene... [more]
sox19b3.289e-3081.82transcription factor Sox-19a [Source:NCBI gene;Acc... [more]
back to top
BLAST of Transcription factor Sox-21 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000052511.12.056e-17299.62SMESG000052511.1[more]
SMESG000077970.11.149e-3181.43SMESG000077970.1[more]
SMESG000011244.14.227e-2645.00SMESG000011244.1[more]
SMESG000011244.15.083e-2645.00SMESG000011244.1[more]
SMESG000067682.16.159e-2378.33SMESG000067682.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004924 ID=SMED30004924|Name=Transcription factor Sox-21|organism=Schmidtea mediterranea sexual|type=transcript|length=1194bp
TCTGTTGATAATCTTGAAGACGAAGAAAGTATTGATAGATGCAAAAGTGA
ACAAACGTTTTGTACCGACTCAGTGGATACTTATGTCGACATTGAAGATG
AAGAAATTGAAAAAATTGACGATGGAATCGATGTTAAATTAACAGAGAAA
ACCGACGAGCTAATCAGTAGCGTTGAACTTTGTCAAGTGAACAACAACTG
TAAAAAATACAATAACATGAAAGTCACCCATGTCAAGCGTCCGATGAACG
CGTTTATGGTTTGGAGTCGAGGGCAACGGAAAAAATGGCCCAAATTAATC
CGAAAATGCATAACTCGGAAATCAGCAAACGATTGGGATCGGAATGGAAA
CTGTTGACCGACTCCCAGAAACGGCCATTTATAGACGAGGCCAAACGTTT
GCGAGCGATTCACATGAAAGAGCACCCGGATTACAAATATCGTCCGAGAC
GAAAACCCAAACAATTGTATAAAAAAGAGAAAATTCAAATCAACGCCACC
ATGGGATCATTTTTATCTGGAAATCATAATTATGAAAAGAATCTTCTTGC
GTCATCGGGATCAAGTCACATGAGCTATTTACTTCCATCAATTAGACCGA
CTCGGCTACCATTTGCTAGTTCTCCTTGGGAATTGTCATCGAACTTTTCA
AATATGTTATCAAATTACGGTCCGAGATCGAGCCTGTTGATTCCACCGAT
AGAAATGGCATTCACAAAAGATTTCACAAAGACCCCAACTGTTAAATTAC
CAAATCATGTCGACGATTTATCTGCAATCTATTCGAGATACCTTTGGAAT
ATTAGACCGAATCTACATTTACCACTGCCTTTTCCAATTCAACCGTACAA
CTCCATATCAAATAAACTTGGATTTCCAACTGATCCGTGTAAGATCTATC
ACAGTGAATCAGTCGAATCGAAATTGAACCAAAACAATAATAATAATAAT
ATCAGCAATAACAACAACAACATCAACAATAATAATAATACTTCAGCGAC
ATGGCAGCAAACAGTTGAAGCGTTATTTGAATCACTTCGTAGAAAAGAAC
CTCAAAATTAAAAAAAAACTGAACATTTCTTTTCATAAAGCAACTGATTT
ATATAAGATTATATTGGATTTCACTGTACATTTATTATAATATTATTTCT
ATTTAAATTAATTAATTGAATTGCAATTTCTGACATAATAATAA
back to top

protein sequence of SMED30004924-orf-1

>SMED30004924-orf-1 ID=SMED30004924-orf-1|Name=SMED30004924-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=259bp
MAQINPKMHNSEISKRLGSEWKLLTDSQKRPFIDEAKRLRAIHMKEHPDY
KYRPRRKPKQLYKKEKIQINATMGSFLSGNHNYEKNLLASSGSSHMSYLL
PSIRPTRLPFASSPWELSSNFSNMLSNYGPRSSLLIPPIEMAFTKDFTKT
PTVKLPNHVDDLSAIYSRYLWNIRPNLHLPLPFPIQPYNSISNKLGFPTD
PCKIYHSESVESKLNQNNNNNNISNNNNNINNNNNTSATWQQTVEALFES
LRRKEPQN*
back to top

protein sequence of SMED30004924-orf-2

>SMED30004924-orf-2 ID=SMED30004924-orf-2|Name=SMED30004924-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=119bp
SVDNLEDEESIDRCKSEQTFCTDSVDTYVDIEDEEIEKIDDGIDVKLTEK
TDELISSVELCQVNNNCKKYNNMKVTHVKRPMNAFMVWSRGQRKKWPKLI
RKCITRKSANDWDRNGNC*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007399nervous system development
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0007275multicellular organism development
GO:0009953dorsal/ventral pattern formation
GO:0045892negative regulation of transcription, DNA-templated
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036910HMG_box_dom_sf
IPR009071HMG_box_dom
Vocabulary: molecular function
TermDefinition
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677DNA binding
GO:0043565sequence-specific DNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009071High mobility group box domainPFAMPF00505HMG_boxcoord: 78..119
e-value: 5.8E-15
score: 55.5
IPR009071High mobility group box domainPROSITEPS50118HMG_BOX_2coord: 78..119
score: 15.326
IPR036910High mobility group box domain superfamilyGENE3DG3DSA:1.10.30.10coord: 75..119
e-value: 7.3E-16
score: 60.4
IPR036910High mobility group box domain superfamilySUPERFAMILYSSF47095HMG-boxcoord: 65..119
NoneNo IPR availablePANTHERPTHR10270SOX TRANSCRIPTION FACTORcoord: 34..119
NoneNo IPR availablePANTHERPTHR10270:SF161SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATEDcoord: 34..119