Endoglin CD105 antigen

Overview
NameEndoglin CD105 antigen
Smed IDSMED30004884
Length (bp)2841
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Endoglin CD105 antigen (SMED30004884) t-SNE clustered cells

Violin plots show distribution of expression levels for Endoglin CD105 antigen (SMED30004884) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Endoglin CD105 antigen (SMED30004884) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Endoglin CD105 antigen (SMED30004884) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30004884

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
headSMED30004884SMESG000048896.1 SmedASXL_013055SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
neuronSMED30004884SMESG000048896.1 dd_Smed_v4_14203_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
headSMED30004884SMESG000048896.1 dd_Smed_v6_14203_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
oocyteSMED30004884SMESG000048896.1 Contig28927newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
oocyteSMED30004884SMESG000048896.1 Contig28927uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
vitelline glandSMED30004884SMESG000048896.1 Contig28927newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
vitelline glandSMED30004884SMESG000048896.1 Contig28927uc_Smed_v2PMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Endoglin CD105 antigen vs. TrEMBL
Match: A0A4E0RJA6 (ZP domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_000016 PE=4 SV=1)

HSP 1 Score: 253.447 bits (646), Expect = 1.347e-66
Identity = 195/644 (30.28%), Postives = 286/644 (44.41%), Query Frame = 1
Query:  310 SCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRET-VGCSCGGNRALITME-SPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVL-------------------NYVDK-------------CQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRA------------AVF---VNHPQSALNSHSDFTATRRKI-----KIHSQLIQEKAFFCGFLDPNDKD---------------FPIKAT--------------QIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENN-NSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLS-SYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLN-PGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSC----------QLKECNEKFASDPQS 1953
            +C    + FC  +VENSVCN  KNECFCK+ FV I+E  +  CK LLTDL+CR+DRDC+HV+ S CHPGAG C CP   ++VPQ   CR +  ++  +   CK C+  NG CFLY+  +   +  +   + +GC C   +  + M+    T NICS KLVD+G  C+ +  +C S +A C  V                    N VD              CQCQ   VA+YQ+TL Y ECFP    + A  QC  C   GG CYD  N    DGC CP   S      ++    CT   +S++  +  + +CY P+S PP+E+L   L   +A            AVF   +N  ++A +S +D  + + +      K+ S L +      GF  P+                  + +K T                 EN +QYE  LEI+ +  +     D  +P KC    +   K++ T + +     + S  LE RV++   NREI        + LD  L+DS+G Y  L +E C   N S S+          FIY+ C  +     + +     P  H Q++     +  T    ++  C   LC   Q C            ++ +   A+DP+S
Sbjct:   42 ACALYDTQFCSRQVENSVCNKVKNECFCKKDFVAIRENGRVTCKTLLTDLKCRVDRDCIHVNRSSCHPGAGYCSCPGNTIYVPQQHACRTR--VSYNQDSVCKSCQLQNGSCFLYESFELSDVEKRFNPSRIGCVCPDGKIPVGMQFDGWTKNICSGKLVDMGFECDQKHAVCRSKRAICDSVSTQTSRSFSPHKVPANFLWPNIVDYSSMANGEQGPKRICQCQNTMVAVYQSTLGYTECFPQLGPKAA--QCHSCIASGGLCYDLNNDGVGDGCVCPPHKSLGSKLRSTGEQSCTGLQVSLNCSDGHLSVCYRPHSAPPYEHLATDLTEGKAVAQLVPTNAENMAVFHEYMNEEKNATSSDTDARSLQFRDPCQLNKMESNLARLSNQMDGFTGPHSTGLDQSIQEQHCVHFDVWQMKQTCGVRIYRLNVSSFISYVENAVQYEALLEIMVNRTRRTPNKDFQIPLKCI---SPPPKRMPTLDYHLRKTVKQSADLEFRVVN-KENREIYATQIGTTIRLDALLLDSSGQYKVLTVEKCQYGNRSTSHTSDASHKMVPFIYKGCPLTNAKVQIPFTNGQYPSDHVQSAPFPAFREGTL-FSLFFKCVFQLCVDPQQCFQASPSCDSGHAQDSDHVTATDPKS 676          
BLAST of Endoglin CD105 antigen vs. TrEMBL
Match: A0A5K3FG97 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 5.820e-66
Identity = 200/685 (29.20%), Postives = 298/685 (43.50%), Query Frame = 1
Query:  283 QRRQNLEIDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPT-TLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDK----------------CQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACP------STHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQ--------------------EKAFFCGFLDPNDKDFP----IKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRN-REIVKIGYNNPVVLDITLID-STGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPGIHYQTSQIIINQPNT---------WKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQS------------RLLYRFTKISRVDKQEETLDKIYGIKDNS-------------CPYSLCLNQLQAVMTS 2088
            Q+ QNL + +C  +A +FC   V NSVCN  KNECFC++GFV +KE     CK LLTDL+CR+D DCVHV+ S CHPGAG C CP   VFVPQL  CR K  L   ++  C  C +  G CF YD  D +  S  T E  GC C   R       P+     C A+LVDIG++CN  DL C S  A C    N +D+                C C   ++ ++Q  LRY+EC+P     +  + C +C   GG+CY  TN+     C CP        + NV+NG       CT  H+    +   + ICY+P+   P+E+L   L +  A   +    ++L S       RR   + S L                          +C  LD    D P    I+   +  + ++Y+G +E+  +    +   D+ LPF C       D K+  A  N   Q   L   + ++ V +N +++ ++     + L  +LI  STG    + +E+CF S   S   P    S   IY     +    N  ++     IH+  SQ+      +         +   ++I C +  C    +C+++  +    SDP              RL  R+  ++ V  Q+E+L  + G  D +             C Y++CL Q Q +  S
Sbjct:   26 QKGQNLAVGACNKEAPSFCDRIVRNSVCNRAKNECFCRKGFVAVKEGDSVACKTLLTDLKCRVDADCVHVNRSSCHPGAGFCTCPGNTVFVPQLNACRTK--LFERKSLVCSSCLKEGGSCFAYDANDRQPDSASTFEPYGCVCPNFRTSTQFRHPSRPQRTCGAQLVDIGELCNNEDLQCRSPLAVC----NPLDEQTWSRKGYQNGPSYGICSCLPNNIPVFQKLLRYFECYP--KAGIKEETCQQCIKNGGECYWLTNTRAE--CKCPLGKSNSQIYGNVNNGV------CTFKHVQTICENGLLLICYVPHWEAPYEDLASHLGSGAAEARLT--AASLGSADSACRLRRATDVTSSLTDLWRAMLTKLSSHSPRAGNATRVGPYCTQLDI-AHDLPLHCGIRIYSVAGDMMKYQGAIEVEMENSPFNRNRDLRLPFTC------IDHKLSKARQNVISQFKHLNANVSMVIVNKNLQDVDQVNEEENISLRFSLISASTGAQGSIAVESCFASVSGSQFSPPSIYSGFPIYAAGCTAN---NKAYR-----IHFDESQLSGRSLQSTFFQVFRIEYFSSLFIRCFVKFCPQSLTCRVESLD---CSDPAQAYTGKKRPGGNHRLFDRWVHLNIVPAQKESL--VTGSVDGTTNANRRLSNDPEPCRYAVCLTQPQLISAS 672          
BLAST of Endoglin CD105 antigen vs. TrEMBL
Match: A0A074YXM6 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=T265_15504 PE=4 SV=1)

HSP 1 Score: 229.565 bits (584), Expect = 1.031e-62
Identity = 136/349 (38.97%), Postives = 193/349 (55.30%), Query Frame = 1
Query:  298 LEIDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRE-----TVGCSCG------GNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCV------KVLNYVDKCQCQERHVAIYQTTLRYYECFPTF---------DERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACP--STHSN-VDNGS------------ASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFV 1221
            L +  C  K   +C+S VENS+CN +KNECFCK GFV I+E  K +C+ LLT+L CR+D DCVHV GS+CHPGAG+CVCPS  ++VPQL  CR+++E    ++  C+ C    G CFLYD KD  + S  T        VGC C       G+  L T+  PT   +C ++LVDIG+ C+  +  C +  A C+      ++ N+  +C C E  VA+YQ  L Y+ECF            ++ +   +C  CH V G CYD  +    DGC CP   THS+ VD+ S            +SL +PCT   +     EE + +CY+P++     NL  Q++AN+ +V +
Sbjct:   32 LHLGDCNRKPVEYCNSLVENSMCNPQKNECFCKHGFVAIQEEEKVVCRTLLTELYCRVDSDCVHVDGSVCHPGAGKCVCPSGKIYVPQLHGCRQRFETKMDQS--CEKCLLKQGTCFLYDLKDQPVNSKHTSNVDQSLAVGCVCPQSVIKHGSENL-TLLVPTDGGLCGSQLVDIGEECDAVNHTCKAQMAMCLPARRDRRLANFSGRCSCPEITVAVYQPNLGYHECFTKIPKPQLSAGHNQDIVNPECAGCHAVEGVCYDMNDDGIGDGCRCPVDRTHSSTVDSDSQPYESPTKHHQQSSLSSPCTRKQVFSSCTEESLTVCYVPHNDDQQINLSNQIQANQCSVHL 377          
BLAST of Endoglin CD105 antigen vs. TrEMBL
Match: A0A5K4F052 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 1.660e-62
Identity = 170/578 (29.41%), Postives = 262/578 (45.33%), Query Frame = 1
Query:  271 ENLIQRRQNLEIDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRET-VGCSCGGNRALITMESPTTLN-ICSAKLVDIGQVCNGRDLICISLKATC-------------------------------VKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQ----------SALNSHSDFT-------------ATRRKIKIHSQLIQEKAF-------------FCGFLDPNDKDF--PIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKC-----------EREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSY-DLPTGAMSESFIYQRCV 1755
            E  +Q+ +NL I +C    S FC  +VENSVCN EKNECFC++GFV I+E  +  CK LLTDL+CR+DRDCVHV+ S CHPGAG C CP   ++VP+   CR ++   +    FC +C +  G CF Y+  +  I   +     VGC C  ++  I+  +   L  +C   LVDIG  C+   L C S+ + C                               ++    +  CQC+  ++ +YQ  L+Y ECF      +  K C KC + GG+CYD  +    DGC CP + S++  G  +    C   H+SV+     + +CY P+++ P+ NL   L  +R+ V +              S L+S ++ T             +    I I +  + E                FC  +D   K+    I+  ++  + +QYEG LE++ +        D  +P KC             +GNL+    +   N  +      Q+ LR+L+   N+EI      + V LD  L + +G Y  +  E C+ +N S + D  +   S   I  RC+
Sbjct:   25 ERSVQKTENLAIGACTQYDSGFCSRQVENSVCNHEKNECFCRKGFVAIRENGRVTCKTLLTDLKCRVDRDCVHVNRSSCHPGAGYCSCPGNTIYVPEKHACRARFTYPSDP--FCDVCLQLKGTCFKYELFERVITDQRVNPNGVGCVCPDHKVSISTRTSDPLKYMCDGNLVDIGSECDDESLFCRSINSVCKPLQEELLLSTNQLHSFKSNLWSENFPSGDHLRRSQIIRTCQCKPGYLPVYQINLKYNECFKILP--MKAKYCQKCVDTGGQCYDLNDDGIGDGCDCPPSLSSIIYGKENSEIYCGTVHVSVNCTNGYLSVCYYPHTYGPYSNLFDDLMNHRSVVRLASDNYLTDTLPLQISGLSSEANRTYHYSNFQNLCILKSENDTIDIGNTFVTESISHDNYHLHGAQTKRFCLNIDVWRKNGLCGIRLYKLSHDTVQYEGILEVLVNTSIRTPSRDKIIPLKCISRTPNRPMNEINDGNLQTIGTMNLANTPTHP----QISLRILN-ENNKEIPSTFVGSRVRLDALLFNPSGSYKHIAAEYCYGNNRSLHSDYFSSDTSTLLIDHRCL 593          
BLAST of Endoglin CD105 antigen vs. TrEMBL
Match: A0A5K4F1C8 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 234.572 bits (597), Expect = 5.640e-60
Identity = 167/570 (29.30%), Postives = 256/570 (44.91%), Query Frame = 1
Query:  295 NLEIDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRET-VGCSCGGNRALITMESPTTLN-ICSAKLVDIGQVCNGRDLICISLKATC-------------------------------VKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQ----------SALNSHSDFT-------------ATRRKIKIHSQLIQEKAF-------------FCGFLDPNDKDF--PIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKC-----------EREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSY-DLPTGAMSESFIYQRCV 1755
            NL   +C    S FC  +VENSVCN EKNECFC++GFV I+E  +  CK LLTDL+CR+DRDCVHV+ S CHPGAG C CP   ++VP+   CR ++   +    FC +C +  G CF Y+  +  I   +     VGC C  ++  I+  +   L  +C   LVDIG  C+   L C S+ + C                               ++    +  CQC+  ++ +YQ  L+Y ECF      +  K C KC + GG+CYD  +    DGC CP + S++  G  +    C   H+SV+     + +CY P+++ P+ NL   L  +R+ V +              S L+S ++ T             +    I I +  + E                FC  +D   K+    I+  ++  + +QYEG LE++ +        D  +P KC             +GNL+    +   N  +      Q+ LR+L+   N+EI      + V LD  L + +G Y  +  E C+ +N S + D  +   S   I  RC+
Sbjct:   45 NLSKRACTQYDSGFCSRQVENSVCNHEKNECFCRKGFVAIRENGRVTCKTLLTDLKCRVDRDCVHVNRSSCHPGAGYCSCPGNTIYVPEKHACRARFTYPSDP--FCDVCLQLKGTCFKYELFERVITDQRVNPNGVGCVCPDHKVSISTRTSDPLKYMCDGNLVDIGSECDDESLFCRSINSVCKPLQEELLLSTNQLHSFKSNLWSENFPSGDHLRRSQIIRTCQCKPGYLPVYQINLKYNECFKILP--MKAKYCQKCVDTGGQCYDLNDDGIGDGCDCPPSLSSIIYGKENSEIYCGTVHVSVNCTNGYLSVCYYPHTYGPYSNLFDDLMNHRSVVRLASDNYLTDTLPLQISGLSSEANRTYHYSNFQNLCILKSENDTIDIGNTFVTESISHDNYHLHGAQTKRFCLNIDVWRKNGLCGIRLYKLSHDTVQYEGILEVLVNTSIRTPSRDKIIPLKCISRTPNRPMNEINDGNLQTIGTMNLANTPTHP----QISLRILN-ENNKEIPSTFVGSRVRLDALLFNPSGSYKHIAAEYCYGNNRSLHSDYFSSDTSTLLIDHRCL 605          
BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Match: SMESG000048896.1 (SMESG000048896.1)

HSP 1 Score: 1568.13 bits (4059), Expect = 0.000e+0
Identity = 775/783 (98.98%), Postives = 778/783 (99.36%), Query Frame = 1
Query:  307 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRFTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSXXXXXXXXXXXXXXXXXFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDTTIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFRAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCSE 2655
            DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPST SNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSAL SHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQEN IQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTR PNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYR+TKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSD TIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSF+AVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMC+E
Sbjct:   41 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTLSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALISHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENSIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRPPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRYTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDATIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFQAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCNE 823          
BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Match: SMESG000048896.1 (SMESG000048896.1)

HSP 1 Score: 1567.36 bits (4057), Expect = 0.000e+0
Identity = 775/783 (98.98%), Postives = 778/783 (99.36%), Query Frame = 1
Query:  307 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRFTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSXXXXXXXXXXXXXXXXXFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDTTIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFRAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCSE 2655
            DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPST SNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSAL SHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQEN IQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTR PNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYR+TKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSD TIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSF+AVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMC+E
Sbjct:   24 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTLSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALISHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENSIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRPPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRYTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDATIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFQAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCNE 806          
BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Match: SMESG000048896.1 (SMESG000048896.1)

HSP 1 Score: 1566.98 bits (4056), Expect = 0.000e+0
Identity = 775/783 (98.98%), Postives = 778/783 (99.36%), Query Frame = 1
Query:  307 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRFTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSXXXXXXXXXXXXXXXXXFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDTTIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFRAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCSE 2655
            DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPST SNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSAL SHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQEN IQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTR PNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYR+TKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSD TIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSF+AVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMC+E
Sbjct:   21 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTLSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALISHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENSIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRPPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRYTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDATIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFQAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCNE 803          
BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Match: SMESG000048896.1 (SMESG000048896.1)

HSP 1 Score: 1566.59 bits (4055), Expect = 0.000e+0
Identity = 775/783 (98.98%), Postives = 778/783 (99.36%), Query Frame = 1
Query:  307 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRFTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSXXXXXXXXXXXXXXXXXFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDTTIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFRAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCSE 2655
            DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPST SNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSAL SHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQEN IQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTR PNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYR+TKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSD TIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSF+AVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMC+E
Sbjct:   35 DSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTLSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSALISHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENSIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRPPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQSRLLYRYTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLLLLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNFYLLTDNNSVANSTDNYDLSDATIPLRDNSLSNTFQLRSEPFERVGNQYTLPHFHRPVPFYDTNQVMMTSFQAVSHSNLKVPDATVSHSSPVVSPNEHPTPLENNLQKINNLENPKLNSKNTNVRYSEMICMCNE 817          
BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Match: SMESG000035626.1 (SMESG000035626.1)

HSP 1 Score: 414.075 bits (1063), Expect = 3.353e-130
Identity = 262/699 (37.48%), Postives = 392/699 (56.08%), Query Frame = 1
Query:  280 IQRRQNLEIDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLTDLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAETGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPTTLNICSAKLVDIGQVCNGRDLICISLKATCVKVLN--YVDKCQCQERHVAIYQTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTHSNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKANRAAVFVNHPQSA--------------LNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDFPIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREG-NLKDKKILTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGFYTDLLIENCFLSNLSSYDLPTGAMSES-FIYQRCVNSTR---SPNVVWKQLNPGIHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKEC----NEKFASDPQSRLLYRFTKISRVDKQEETLDKI-YGIKDNSCPYSLCLNQLQAVMTSXXXXXXXXXXXXXXXXXFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNG-NNQNFYLLTDNNSVANSTD 2295
            IQR QN+ + +C  +A N+C+ +VENS+CNT K+ECFC+ GFV IKE  K  CK LLTDL CRIDRDC+HV+GSMCHPGAGQCVCP++H++V  +  CR+K++       FC+ CR+N G+CF Y  +D +    K ++ +GC+C  +R    M S +T  IC   LVDIG  CN RDL C S KA C ++ N   +  C C   +VA+YQ TLRY+ECFP   E  A  +C KC    G CYD  N  + D C C +  SN  +G  SL+ PCTI+H+SV      + +CY+P++ PP+ +L +QLK  R+   V  P++               ++    F   R  +KI  +L+ +   FC  +D  D+   I+A ++++N I+Y  +L I+ D++K +   D   P  C  +  N+K+      ++  S  + SL L+LR+++   N E   I +N+ V LDI+L+DS G ++++ I  CF+++    +    + S    +Y +C N +       VVW   + GIHYQT +    QP      ++ HC I LC  Q  C         +E  A + Q ++L R   ++        +  I +G +   C YSLCL QLQA+MT+VL+L LL+LVVIL++IL +RQR +QK ++ K  +    + +   +   N    Q  YLL+D+ S+  S D
Sbjct:   36 IQRSQNIPMGTCATRAPNYCNDQVENSICNTVKDECFCRNGFVAIKEGSKISCKTLLTDLICRIDRDCMHVTGSMCHPGAGQCVCPAQHIYVEYINACRRKFD--DVNDPFCQNCRQNGGQCFKYKSQDRKNSPVKNKDAIGCACNNHR----MTSDSTDTICDVHLVDIGGYCNDRDLKCRSKKAICSRIQNSDTISSCNCITGYVAVYQKTLRYFECFPVVSES-ASSRCAKCFQSEGYCYDINNDQEGDSCLCQNKFSNEMDGPNSLIKPCTISHVSVSCSNYHMNVCYIPHNRPPYRSLGVQLKNGRSLAVVKSPKATNKILPMPRRQKPPDVSYSEQFINNR--LKISGELMNK---FCANIDLTDERI-IQADKLKKNNIRYSASLHIIVDSIKSNPGKDFVFPLTCVTKAINIKENS--KNQSFASENEHSLSLDLRIINPETNAETNNINFNDQVKLDISLVDSQGTFSEIDILKCFVNDQKVIEEKNHSTSTGNLLYSKCDNLSNYYSRQRVVWLHTSHGIHYQTLEFRP-QPLNNSSILFFHCHILLCRHQILCSKHGFCGFPDEISAREDQFKVLQRSAYLNFHRSNNFDIPSISHGKEIKECRYSLCLTQLQAIMTTVLMLFLLVLVVILVIILHRRQRAIQKIAVKKKKMLLNSSGFHQVNAMCNQPYGQKLYLLSDSGSLTTSID 718          
The following BLAST results are available for this feature:
BLAST of Endoglin CD105 antigen vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0RJA61.347e-6630.28ZP domain-containing protein OS=Fasciola hepatica ... [more]
A0A5K3FG975.820e-6629.20Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A074YXM61.031e-6238.97Uncharacterized protein (Fragment) OS=Opisthorchis... [more]
A0A5K4F0521.660e-6229.41Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A5K4F1C85.640e-6029.30Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
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BLAST of Endoglin CD105 antigen vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Endoglin CD105 antigen vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000048896.10.000e+098.98SMESG000048896.1[more]
SMESG000048896.10.000e+098.98SMESG000048896.1[more]
SMESG000048896.10.000e+098.98SMESG000048896.1[more]
SMESG000048896.10.000e+098.98SMESG000048896.1[more]
SMESG000035626.13.353e-13037.48SMESG000035626.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004884 ID=SMED30004884|Name=Endoglin CD105 antigen|organism=Schmidtea mediterranea sexual|type=transcript|length=2841bp
ACCGATTGCCGCCTGGAATTCTCAGAACGGTTTTATGTCTTTGCGTAGAG
CTACGTTGATTGCTGCGTCCTCAACGTTATCACACTTGGAATCGGGTTTG
TGATCTGTCGGATTTTTGCTTACAACTCATTATATAACATCAATTTTTTC
ATTATGAAATTCTATATGAGATTTTTATTGTCAATGCTCTGGTCGTTCTT
CGCTCTCGGTCCACCTCACAACCGAATGTCTTCGGCTAACAGTATTTTTC
AAATGTCAAATGTCGGGACGGAAAATTTGATTCAAAGGAGACAGAATTTA
GAAATTGACAGCTGCCTCGACAAAGCCTCGAACTTCTGCCACTCAAAAGT
GGAGAACAGCGTCTGCAATACGGAGAAAAATGAATGTTTCTGCAAGCGTG
GATTTGTCGTTATCAAAGAAAGACACAAAGCAATTTGTAAACCATTGCTC
ACTGACCTTCAGTGCAGAATAGACCGAGACTGCGTCCATGTCAGCGGCAG
CATGTGTCATCCAGGAGCCGGCCAATGCGTCTGTCCAAGCAGGCATGTTT
TCGTTCCTCAGCTCTTTCTATGTCGTAAGAAATATGAATTGGCTACAGCG
GAAACGGGATTCTGTAAGATTTGCAGAGAGAACAATGGAGAATGTTTTCT
TTACGATCCCAAAGATACGAGAATCATCAGTTACAAGACTAGAGAAACAG
TGGGCTGCTCGTGTGGCGGAAATAGAGCGCTGATCACCATGGAGTCACCA
ACCACACTGAATATTTGTTCAGCTAAGCTCGTGGATATTGGCCAAGTGTG
CAACGGGAGAGATCTGATCTGCATCAGCTTGAAGGCCACATGTGTCAAAG
TCCTGAATTATGTTGACAAATGTCAATGTCAAGAAAGACATGTCGCCATA
TATCAAACGACACTTCGATATTACGAATGCTTTCCGACTTTTGATGAAAG
ACTTGCTCCAAAACAATGCACAAAGTGTCATAATGTTGGTGGAAAATGCT
ACGATAGTACGAATTCCGATAAACCCGACGGATGTGCTTGCCCTAGCACG
CATTCAAATGTAGATAACGGATCAGCGTCCCTCGTTAACCCATGCACAAT
AAACCATCTTTCAGTTGATTTTCAAGAAGAAAAAATAAAAATTTGTTACC
TTCCTTATTCATTTCCTCCGTTTGAGAACTTACAGTTACAACTGAAAGCT
AACCGAGCTGCCGTTTTTGTAAACCACCCACAATCGGCACTTAATTCTCA
TTCTGATTTTACCGCAACTAGAAGGAAAATTAAAATTCATTCACAATTAA
TTCAGGAAAAAGCATTTTTCTGTGGGTTTTTAGATCCAAATGACAAAGAT
TTTCCAATTAAAGCCACCCAAATTCAGGAAAATAGAATTCAATATGAAGG
AACGTTGGAAATTGTCCGTGACGCAATGAAGCACGATTTGGTTGTTGACG
TTTCACTTCCCTTCAAATGTGAACGTGAGGGCAATTTAAAAGACAAGAAA
ATCCTAACTGCAGAAAACAACAATTCTGGACAGCAGGATTCTCTTCAGCT
GGAACTGCGAGTTTTGGATGTAACGAGAAACCGGGAAATCGTCAAAATTG
GATATAATAATCCGGTCGTATTAGATATAACACTCATAGATTCGACAGGG
TTCTACACTGACTTACTGATTGAGAATTGCTTTCTCTCCAATCTCTCCTC
CTATGATTTGCCTACGGGAGCAATGTCAGAAAGTTTTATTTACCAAAGAT
GTGTCAATTCAACAAGATCACCAAATGTAGTTTGGAAACAGCTTAACCCT
GGAATTCATTATCAAACCTCACAAATCATCATTAACCAACCCAATACTTG
GAAAGGTGATGTATATATCCATTGCCAGATATCTCTATGTACCAGCCAAC
AATCGTGCCAGCTAAAGGAGTGCAACGAAAAGTTCGCCAGTGATCCTCAG
AGTCGCTTGTTGTATCGATTTACGAAGATTTCGCGTGTTGACAAGCAGGA
AGAAACCCTCGATAAAATTTACGGAATAAAAGACAACAGTTGTCCATATT
CTCTCTGCCTCAACCAACTTCAAGCGGTAATGACATCGGTTCTTTTGTTG
CTCCTCCTCTTGTTAGTTGTTATTCTTCTCCTCATCTTGTTCAAGCGACA
GAGAATGCTACAGAAGTTCTCAATGGCCAAGTTAAACATTCCTTCAACAG
TTAATAGTTATAAAACCAGTAGCGATTTCATGAACGGCAACAATCAGAAT
TTCTATCTTCTGACAGACAATAATTCGGTAGCTAATTCAACTGACAATTA
TGATCTTTCCGATACAACTATCCCTCTTCGTGACAACAGCCTTAGTAATA
CTTTTCAATTGCGATCCGAACCGTTTGAAAGGGTTGGGAATCAATATACT
CTTCCGCATTTTCACAGGCCAGTTCCGTTTTATGACACAAATCAAGTCAT
GATGACATCATTCCGAGCAGTTTCTCATTCAAACCTTAAGGTTCCAGATG
CAACCGTTTCACATAGTTCTCCAGTGGTGTCTCCAAATGAACATCCAACG
CCATTGGAAAACAATTTGCAAAAAATCAACAACTTGGAAAATCCAAAGTT
AAACAGTAAAAATACGAATGTCAGATATTCAGAAATGATCTGCATGTGCA
GCGAATAATTGTAAGAAAGTTGTCATAATAACAGCGGGTGGTCGATCTTG
TGTACAATTGTCTCATTTGTGTACAATTATCATATTTTCTATACGTTTCA
GTGTGAGATTGGAATTTACAAATCTTTTCTTATTGTAAATGAACTATTAA
ATTTTTGATTTTGATTTTTCAATATATTTTTGAAATTTTTC
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protein sequence of SMED30004884-orf-1

>SMED30004884-orf-1 ID=SMED30004884-orf-1|Name=SMED30004884-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=835bp
MKFYMRFLLSMLWSFFALGPPHNRMSSANSIFQMSNVGTENLIQRRQNLE
IDSCLDKASNFCHSKVENSVCNTEKNECFCKRGFVVIKERHKAICKPLLT
DLQCRIDRDCVHVSGSMCHPGAGQCVCPSRHVFVPQLFLCRKKYELATAE
TGFCKICRENNGECFLYDPKDTRIISYKTRETVGCSCGGNRALITMESPT
TLNICSAKLVDIGQVCNGRDLICISLKATCVKVLNYVDKCQCQERHVAIY
QTTLRYYECFPTFDERLAPKQCTKCHNVGGKCYDSTNSDKPDGCACPSTH
SNVDNGSASLVNPCTINHLSVDFQEEKIKICYLPYSFPPFENLQLQLKAN
RAAVFVNHPQSALNSHSDFTATRRKIKIHSQLIQEKAFFCGFLDPNDKDF
PIKATQIQENRIQYEGTLEIVRDAMKHDLVVDVSLPFKCEREGNLKDKKI
LTAENNNSGQQDSLQLELRVLDVTRNREIVKIGYNNPVVLDITLIDSTGF
YTDLLIENCFLSNLSSYDLPTGAMSESFIYQRCVNSTRSPNVVWKQLNPG
IHYQTSQIIINQPNTWKGDVYIHCQISLCTSQQSCQLKECNEKFASDPQS
RLLYRFTKISRVDKQEETLDKIYGIKDNSCPYSLCLNQLQAVMTSVLLLL
LLLLVVILLLILFKRQRMLQKFSMAKLNIPSTVNSYKTSSDFMNGNNQNF
YLLTDNNSVANSTDNYDLSDTTIPLRDNSLSNTFQLRSEPFERVGNQYTL
PHFHRPVPFYDTNQVMMTSFRAVSHSNLKVPDATVSHSSPVVSPNEHPTP
LENNLQKINNLENPKLNSKNTNVRYSEMICMCSE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000074oocyte
PLANA:0000099neuron
PLANA:0000231vitelline gland
PLANA:0000418head
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..19
score: 0.666
NoneNo IPR availableTMHMMTMhelixcoord: 641..663