Discoidin domain-containing receptor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004881 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Match: DDR1 (discoidin domain receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:2730]) HSP 1 Score: 119.013 bits (297), Expect = 7.356e-29 Identity = 69/249 (27.71%), Postives = 111/249 (44.58%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ H +A PG + L+++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 8 LVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFLSAHQLEDKAA-----EGAPGDGQAAQGPTISYPM-----------LLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 202
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Match: DDR2 (discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731]) HSP 1 Score: 122.094 bits (305), Expect = 1.870e-27 Identity = 77/249 (30.92%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N + ++ C TD+ P C+I ++ G L++F+ RH P SS+ SD S + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVC---ITDD----PL----------CMITEYMENGDLNQFLSRHEPPNSSS----------SDVRTVSYTN---------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 789 HSP 2 Score: 100.523 bits (249), Expect = 9.845e-21 Identity = 89/349 (25.50%), Postives = 160/349 (45.85%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVP----KEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVI 1251
AWCP+ V P+ KE++Q+D L ++ + T G G G F + ++Y R +G+ W ++N ++++GN + ++ + + I+AR +R IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A I+F D +AR++ V L A ++ F W++ +E+ F ++ E PT T + M N ++ C++
Sbjct: 71 AWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNA--ISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTY-----DPMLKVDDSNTRILIGCLV 406
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Match: DDR2 (discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731]) HSP 1 Score: 122.094 bits (305), Expect = 1.870e-27 Identity = 77/249 (30.92%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N + ++ C TD+ P C+I ++ G L++F+ RH P SS+ SD S + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVC---ITDD----PL----------CMITEYMENGDLNQFLSRHEPPNSSS----------SDVRTVSYTN---------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 789 HSP 2 Score: 100.523 bits (249), Expect = 9.845e-21 Identity = 89/349 (25.50%), Postives = 160/349 (45.85%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVP----KEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVI 1251
AWCP+ V P+ KE++Q+D L ++ + T G G G F + ++Y R +G+ W ++N ++++GN + ++ + + I+AR +R IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A I+F D +AR++ V L A ++ F W++ +E+ F ++ E PT T + M N ++ C++
Sbjct: 71 AWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNA--ISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTY-----DPMLKVDDSNTRILIGCLV 406
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Match: DDR2 (discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731]) HSP 1 Score: 122.094 bits (305), Expect = 1.870e-27 Identity = 77/249 (30.92%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N + ++ C TD+ P C+I ++ G L++F+ RH P SS+ SD S + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVC---ITDD----PL----------CMITEYMENGDLNQFLSRHEPPNSSS----------SDVRTVSYTN---------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 789 HSP 2 Score: 100.523 bits (249), Expect = 9.845e-21 Identity = 89/349 (25.50%), Postives = 160/349 (45.85%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVP----KEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVI 1251
AWCP+ V P+ KE++Q+D L ++ + T G G G F + ++Y R +G+ W ++N ++++GN + ++ + + I+AR +R IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A I+F D +AR++ V L A ++ F W++ +E+ F ++ E PT T + M N ++ C++
Sbjct: 71 AWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNA--ISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTY-----DPMLKVDDSNTRILIGCLV 406
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Match: DDR1 (discoidin domain receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:2730]) HSP 1 Score: 119.013 bits (297), Expect = 2.206e-26 Identity = 69/249 (27.71%), Postives = 111/249 (44.58%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ H +A PG + L+++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 651 LVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFLSAHQLEDKAA-----EGAPGDGQAAQGPTISYPM-----------LLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 845 HSP 2 Score: 95.1301 bits (235), Expect = 4.296e-19 Identity = 80/317 (25.24%), Postives = 137/317 (43.22%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG----IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHN--ADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
++S+ D AWCP V P +EY+QVD + L ++ + T G G G F + L Y R +G W +K+ ++I GN D + + ++AR +R P ++ +VCL+ YG + DG++ Y+ P G + + + L D YDG L G+ L D ++ ++VGW N + +EM F FD++R + + H N + F G + + +HN +L AR + V L A+F++ F W++ +E+ F ++V
Sbjct: 60 RHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVY-LNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPG---YDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAM---AWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDV 368
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.783 bits (299), Expect = 3.589e-27 Identity = 95/309 (30.74%), Postives = 157/309 (50.81%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----------NFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRL--QWIVLTEVQFTTN 1131
AWCPKN++ SKE++Q+ F ++ + T G D+G + + F + Y R + + W YK++ + + I N D+ + IIARRIRI+P+SN T+TVC++ +G F+D +V Y++ QGD+ Q D YDG + N L GIG+L D GEV +VGW+ +N +++ F F ++R + G+ H N+ KK+ FSSA FSI G+ + + F + D + + RW+ + +++ AK ++ L F W+ ++EV F +N
Sbjct: 37 AWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDL----QSGISYHDFSYDG--NLANSPHLTGGIGKLYD-------------GEVGKNNVFVNHHKWVGWRR-KRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTI--VHFNNPEDTESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESN 323 HSP 2 Score: 99.7525 bits (247), Expect = 5.037e-21 Identity = 81/315 (25.71%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 2122 DYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF-----CVPQNLTNIDSTANYVKCLS 3051
DY E+ L +I +K+ IG G +G + V VK ++ + SF + I L + N V++VG C + KP I CI M++ G L +I ++ P TS C I I Q++ G+++LE +HRD+A RNC+V ++ I D M + + ++Y + + LP++WM+WEA+L G++S+ SDVW FGV W++ + C +PY V +NL ++ ST + + LS
Sbjct: 480 DYGEVYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLENRKVAVKKLH-GISQADEFSFHREIRVLGSLKHPNVVEVVGVC---------------TIQKP-ILCI-MEYMENGDLKSYILKN---------------PTIQTS-------------------QC-ISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKV---------------------EGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLS 720
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.783 bits (299), Expect = 3.589e-27 Identity = 95/309 (30.74%), Postives = 157/309 (50.81%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----------NFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRL--QWIVLTEVQFTTN 1131
AWCPKN++ SKE++Q+ F ++ + T G D+G + + F + Y R + + W YK++ + + I N D+ + IIARRIRI+P+SN T+TVC++ +G F+D +V Y++ QGD+ Q D YDG + N L GIG+L D GEV +VGW+ +N +++ F F ++R + G+ H N+ KK+ FSSA FSI G+ + + F + D + + RW+ + +++ AK ++ L F W+ ++EV F +N
Sbjct: 37 AWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDL----QSGISYHDFSYDG--NLANSPHLTGGIGKLYD-------------GEVGKNNVFVNHHKWVGWRR-KRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTI--VHFNNPEDTESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESN 323 HSP 2 Score: 99.7525 bits (247), Expect = 5.037e-21 Identity = 81/315 (25.71%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 2122 DYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF-----CVPQNLTNIDSTANYVKCLS 3051
DY E+ L +I +K+ IG G +G + V VK ++ + SF + I L + N V++VG C + KP I CI M++ G L +I ++ P TS C I I Q++ G+++LE +HRD+A RNC+V ++ I D M + + ++Y + + LP++WM+WEA+L G++S+ SDVW FGV W++ + C +PY V +NL ++ ST + + LS
Sbjct: 480 DYGEVYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLENRKVAVKKLH-GISQADEFSFHREIRVLGSLKHPNVVEVVGVC---------------TIQKP-ILCI-MEYMENGDLKSYILKN---------------PTIQTS-------------------QC-ISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKV---------------------EGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLS 720
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Match: ddr-2 (Discoidin domain-containing receptor tyrosine kinase B [Source:UniProtKB/Swiss-Prot;Acc:Q95ZV7]) HSP 1 Score: 119.398 bits (298), Expect = 4.684e-27 Identity = 95/309 (30.74%), Postives = 157/309 (50.81%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----------NFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRL--QWIVLTEVQFTTN 1131
AWCPKN++ SKE++Q+ F ++ + T G D+G + + F + Y R + + W YK++ + + I N D+ + IIARRIRI+P+SN T+TVC++ +G F+D +V Y++ QGD+ Q D YDG + N L GIG+L D GEV +VGW+ +N +++ F F ++R + G+ H N+ KK+ FSSA FSI G+ + + F + D + + RW+ + +++ AK ++ L F W+ ++EV F +N
Sbjct: 67 AWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDL----QSGISYHDFSYDG--NLANSPHLTGGIGKLYD-------------GEVGKNNVFVNHHKWVGWRR-KRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTI--VHFNNPEDTESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESN 353 HSP 2 Score: 99.7525 bits (247), Expect = 6.004e-21 Identity = 81/315 (25.71%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 2122 DYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF-----CVPQNLTNIDSTANYVKCLS 3051
DY E+ L +I +K+ IG G +G + V VK ++ + SF + I L + N V++VG C + KP I CI M++ G L +I ++ P TS C I I Q++ G+++LE +HRD+A RNC+V ++ I D M + + ++Y + + LP++WM+WEA+L G++S+ SDVW FGV W++ + C +PY V +NL ++ ST + + LS
Sbjct: 510 DYGEVYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLENRKVAVKKLH-GISQADEFSFHREIRVLGSLKHPNVVEVVGVC---------------TIQKP-ILCI-MEYMENGDLKSYILKN---------------PTIQTS-------------------QC-ISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKV---------------------EGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLS 750
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 100.138 bits (248), Expect = 5.750e-21 Identity = 73/288 (25.35%), Postives = 118/288 (40.97%), Query Frame = 1
Query: 2146 KLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSV-------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
K+ +I ++ +++ IG G++G + GIY + V VK D + R + I + N +K++G C + D L + ++ G LH+ ++ P + T +YIA QI+ GM +L +HRDLATRNC+VG +I I D + + DY K+L +P++WMS EA+ +GR+S SDVWSFGV W++ +F + +PY
Sbjct: 581 KVFEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVC------------YMDNSL-----LAVFEYMVHGDLHELLKVRVPPADHDMGGITEANAE-------------------------FLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYY---KMLH------------------RSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGR-QPY 804
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 99.7525 bits (247), Expect = 6.211e-21 Identity = 73/288 (25.35%), Postives = 118/288 (40.97%), Query Frame = 1
Query: 2146 KLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSV-------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
K+ +I ++ +++ IG G++G + GIY + V VK D + R + I + N +K++G C + D L + ++ G LH+ ++ P + T +YIA QI+ GM +L +HRDLATRNC+VG +I I D + + DY K+L +P++WMS EA+ +GR+S SDVWSFGV W++ +F + +PY
Sbjct: 555 KVFEITPSQLSVREKIGEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVC------------YMDNSL-----LAVFEYMVHGDLHELLKVRVPPADHDMGGITEANAE-------------------------FLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYY---KMLH------------------RSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGR-QPY 778
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Match: Ddr (gene:FBgn0053531 transcript:FBtr0344771) HSP 1 Score: 134.035 bits (336), Expect = 2.729e-31 Identity = 104/422 (24.64%), Postives = 173/422 (41.00%), Query Frame = 1
Query: 2137 IMEKLSKIDIEKMELQKLI-----GSGRYGSI---KKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTH-QGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILI--TDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQK 3369
I E+ + +++ Q L+ GSG +G + + + N ++V V + +R F L ++S N ++VG C L+ CI+ ++H G L++F++ H S + + LS CL+YIA QI+ GM LE +HRDLATR+CI+GP L + + T ++ + + DY + S QP +P++WM+WE+VL G++++KSDVWSF V W++LTF + +PY EH D S++ E++ I + LP+P + REI DL+ CW + S+RP F++I ++L++K
Sbjct: 742 INEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGAC-----------------LRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKS-------------------------LSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQS-------------QP---MPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPY-----------------------------EHLSDKSVI---ENIGLIYRDYKMHELLPMPP--------------------------------NCPREIYDLMCECWQRDESSRPSFREIHLYLQRK 1041 HSP 2 Score: 123.25 bits (308), Expect = 5.604e-28 Identity = 94/336 (27.98%), Postives = 168/336 (50.00%), Query Frame = 1
Query: 142 LSDDAFSCSSFRD--NFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXG---EVNFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTT 1128
++D + SS D N P AR K N AWCPK+ V EY+QVD + +S + T G G + + ++Y R W R+++ +++ GN+++ + + ++ A ++R+ P S +TVCL+ G + +G+V YS+P+G + L D+ YDG E + D+ + G+GQL+D +++ + NG ++GW+N R +E+IF F+ VR + V H N K++ +F A+ FSIGG + + + F + DL L AR + + L ++V++ L F +W++++E+ F +
Sbjct: 117 IADFQITASSAHDMGNVGPQHARLKIDNNG-----GAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKG---MQRGMDIDLSDKTYDGYE--EGDHYVN-GLGQLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFS--GEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFIS 439
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Match: Ddr (gene:FBgn0053531 transcript:FBtr0344770) HSP 1 Score: 134.035 bits (336), Expect = 2.729e-31 Identity = 104/422 (24.64%), Postives = 173/422 (41.00%), Query Frame = 1
Query: 2137 IMEKLSKIDIEKMELQKLI-----GSGRYGSI---KKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTH-QGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILI--TDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQK 3369
I E+ + +++ Q L+ GSG +G + + + N ++V V + +R F L ++S N ++VG C L+ CI+ ++H G L++F++ H S + + LS CL+YIA QI+ GM LE +HRDLATR+CI+GP L + + T ++ + + DY + S QP +P++WM+WE+VL G++++KSDVWSF V W++LTF + +PY EH D S++ E++ I + LP+P + REI DL+ CW + S+RP F++I ++L++K
Sbjct: 742 INEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGAC-----------------LRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKS-------------------------LSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQS-------------QP---MPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPY-----------------------------EHLSDKSVI---ENIGLIYRDYKMHELLPMPP--------------------------------NCPREIYDLMCECWQRDESSRPSFREIHLYLQRK 1041 HSP 2 Score: 123.25 bits (308), Expect = 5.604e-28 Identity = 94/336 (27.98%), Postives = 168/336 (50.00%), Query Frame = 1
Query: 142 LSDDAFSCSSFRD--NFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXG---EVNFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTT 1128
++D + SS D N P AR K N AWCPK+ V EY+QVD + +S + T G G + + ++Y R W R+++ +++ GN+++ + + ++ A ++R+ P S +TVCL+ G + +G+V YS+P+G + L D+ YDG E + D+ + G+GQL+D +++ + NG ++GW+N R +E+IF F+ VR + V H N K++ +F A+ FSIGG + + + F + DL L AR + + L ++V++ L F +W++++E+ F +
Sbjct: 117 IADFQITASSAHDMGNVGPQHARLKIDNNG-----GAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKG---MQRGMDIDLSDKTYDGYE--EGDHYVN-GLGQLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFS--GEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFIS 439
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Match: smal (gene:FBgn0085409 transcript:FBtr0329980) HSP 1 Score: 130.568 bits (327), Expect = 1.704e-30 Identity = 101/359 (28.13%), Postives = 175/359 (48.75%), Query Frame = 1
Query: 142 LSDDAFSCSSFRDNFF--PYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXG---EVNFVGWQNFDKN---RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSK 1191
++D + SS D F P AR K + AWCPK+ V KEY+QVD ++ + T G G + + L+Y R W R+KN +++ GN+++ + + I A +IRI P +TVCL+ G + +G+V YS+P+G ++ L D+ YDG E + D + G+GQL+D +++ + +G ++GW+N + +E++F FD VR + H N K++ +F A+ FSIGG + + + F + D + AR + + L K++++ L F ++WI+L+E+ F + VP T++Q + S S+
Sbjct: 89 ITDAQITASSAHDMAFVGPQHARLKTDNDG-----GAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRPGFDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEEGIVSYSIPKG---VQRGMEVDLSDKTYDGNE--QGDRYVD-GLGQLVDGQKGKDNFRTDIHGFGKGYEWIGWRNDTPGLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIGGRYF--SGEPVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFIS-VPAMGNFTDEQEQRSNSPSQ 433
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Match: smal (gene:FBgn0085409 transcript:FBtr0112617) HSP 1 Score: 130.568 bits (327), Expect = 1.704e-30 Identity = 101/359 (28.13%), Postives = 175/359 (48.75%), Query Frame = 1
Query: 142 LSDDAFSCSSFRDNFF--PYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXG---EVNFVGWQNFDKN---RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSK 1191
++D + SS D F P AR K + AWCPK+ V KEY+QVD ++ + T G G + + L+Y R W R+KN +++ GN+++ + + I A +IRI P +TVCL+ G + +G+V YS+P+G ++ L D+ YDG E + D + G+GQL+D +++ + +G ++GW+N + +E++F FD VR + H N K++ +F A+ FSIGG + + + F + D + AR + + L K++++ L F ++WI+L+E+ F + VP T++Q + S S+
Sbjct: 89 ITDAQITASSAHDMAFVGPQHARLKTDNDG-----GAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRPGFDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEEGIVSYSIPKG---VQRGMEVDLSDKTYDGNE--QGDRYVD-GLGQLVDGQKGKDNFRTDIHGFGKGYEWIGWRNDTPGLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIGGRYF--SGEPVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFIS-VPAMGNFTDEQEQRSNSPSQ 433
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Match: smal (gene:FBgn0085409 transcript:FBtr0329979) HSP 1 Score: 130.183 bits (326), Expect = 3.999e-30 Identity = 101/359 (28.13%), Postives = 175/359 (48.75%), Query Frame = 1
Query: 142 LSDDAFSCSSFRDNFF--PYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXG---EVNFVGWQNFDKN---RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSK 1191
++D + SS D F P AR K + AWCPK+ V KEY+QVD ++ + T G G + + L+Y R W R+KN +++ GN+++ + + I A +IRI P +TVCL+ G + +G+V YS+P+G ++ L D+ YDG E + D + G+GQL+D +++ + +G ++GW+N + +E++F FD VR + H N K++ +F A+ FSIGG + + + F + D + AR + + L K++++ L F ++WI+L+E+ F + VP T++Q + S S+
Sbjct: 89 ITDAQITASSAHDMAFVGPQHARLKTDNDG-----GAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRPGFDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEEGIVSYSIPKG---VQRGMEVDLSDKTYDGNE--QGDRYVD-GLGQLVDGQKGKDNFRTDIHGFGKGYEWIGWRNDTPGLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIGGRYF--SGEPVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFIS-VPAMGNFTDEQEQRSNSPSQ 433
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Match: ddr2a (discoidin domain receptor tyrosine kinase 2a [Source:ZFIN;Acc:ZDB-GENE-090316-2]) HSP 1 Score: 123.635 bits (309), Expect = 4.054e-28 Identity = 75/249 (30.12%), Postives = 115/249 (46.18%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C S D L C+I ++ G L++F+ RH +I +N P S L ++A+QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W++LTFC+ +PY
Sbjct: 616 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCMSS-----------DPL------CMITEYMENGDLNQFLSRHE---PEGMIALLSNAPTVSYSN--------------------LHHMASQIASGMKYLSSLNFVHRDLATRNCLVGKNFTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTSSDVWAFGVTLWEMLTFCKEQPY 803 HSP 2 Score: 97.8265 bits (242), Expect = 4.100e-20 Identity = 90/376 (23.94%), Postives = 169/376 (44.95%), Query Frame = 1
Query: 34 ELNIQFVIFVLLTGFIFSQFLPSFRGKDTNYNLINDLSDDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGP-NSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSA--RFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
+++ +I + L+G + SQ P + L +D + S + ++ K + + AWCP+ P N KE++Q+D + L ++ + T G G G F + + Y R+ GS W ++N ++IEGN ++ ++ + + IIAR +R +P+ + + VC++ YG + DG+V Y+ P G ++ L D +YDG + G+GQL D + + + V ++VGW N N +E++F FD+ R + H N + + F F + E A ++F D +AR++ V+L + A ++ F W++ +E+ F ++
Sbjct: 14 KMHFPLLILLYLSGAVQSQVNPGVCRSPLGMSRGQILDEDISASSQWSES-----TAAKYGRLDCEEGDGAWCPEIPAEPENMKEFLQIDLRSLHFITLVGTQGRHAGGIGNEFAQTYKIKYSRD-GSRWISWRNRQGKEVIEGNRNAYDIVLKDLEPPIIARFVRFMPVIDHSMNVCMRVELYGCEWLDGLVSYNSPLGQQMSLNGQHIYLNDSVYDGAMSYS----MTEGLGQLTDGMCGLDDFTLSHVYNVWPGYDYVGWTNESFPNGYVEIMFEFDRTRNFTTMKVHCNNMFSRRVKTFQKVVCYFRSELDWE-----ATPVSFSPVMDDVNPSARFVTVSLYNHMASAIKCQYYFSDIWMMFSEITFQSDT 374
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Match: ddr2b (discoidin domain receptor tyrosine kinase 2b [Source:ZFIN;Acc:ZDB-GENE-060503-361]) HSP 1 Score: 117.857 bits (294), Expect = 2.744e-26 Identity = 75/296 (25.34%), Postives = 127/296 (42.91%), Query Frame = 1
Query: 2149 LSKIDIEKMELQKLIGSGRYGSIKKGIYNGS----------------VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L + +++ ++ +G G++G + G +V VK + D + R F+K I + ++ N ++++ C ++ C+I ++ G L++F+ RH ++T+ G+ LI +A+QIS GM +L +HRDLATRNC+VG I I D M N ++ DY I Q LP++WMSWE++L G+++ SDVW+FGV W++LT C+ +PY
Sbjct: 547 LEEFPRDRLTFKEKLGEGQFGEVHLCEAEGMQEFMKDHCDDICVDPMLVAVKTLREDADKNARNDFMKEIRIISRLRDPNIIRLLAVC-----------------VESDPLCMITEYMENGDLNQFLSRHQLQEDGVQADSTSISYGT------------------------LINMASQISSGMKYLSSLNFVHRDLATRNCLVGMNNIIKIADFGMSRNLYRGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPY 780 HSP 2 Score: 96.2857 bits (238), Expect = 1.105e-19 Identity = 82/314 (26.11%), Postives = 144/314 (45.86%), Query Frame = 1
Query: 232 DSPQAWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHIL-------NDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTN 1131
D AWCP +S KE++Q+D + L ++ + T G +G F + + Y R +G+ W +++ ++IEGN ++ ++ + + IIAR +R +P+++ + VC++ YG + DG+V YS P G T + L D +YDG + + G+GQL D + V ++VGW N +EM F FD+VR + ++L N + +F A F + + FK AD +AR++ V L + A +R F W++ +E+ F ++
Sbjct: 63 DGDGAWCPDVMAEAHSLKEFLQIDLRTLHFVTLVGTQGRHADGVGNEFAQRYRIKYSR-DGTRWVSWRDRQGRQIIEGNSNAYDIVLKDLEPPIIARFVRFMPVTDPSMIVCMRVELYGCEWLDGLVSYSAPAGQQMTFRGQQIYLNDTVYDG----AVSSSMAEGLGQLTDGSWGLDDFTKSQVYGVWPGYDYVGWTNASLPGGSVEMTFEFDRVRNFTSMKINLLVQQVHCNNMYAWGVKMFRQAVCSFRSDADWE---PNPVFFKPKADSISPSARFITVALGNRMASAIRCRFAFSDIWMMFSEIAFQSD 368
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Match: ddr2l (discoidin domain receptor family, member 2, like [Source:ZFIN;Acc:ZDB-GENE-041210-162]) HSP 1 Score: 114.005 bits (284), Expect = 4.719e-25 Identity = 71/249 (28.51%), Postives = 118/249 (47.39%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++++ N ++++ C S D L C++ ++ G L+ F+ + R + S L +A NN P + L++++ QIS GM +L +HRDLATRNC++ L+I I+D M N + DY I Q LP++WM+WE++L G++++ SDVW+FGV W++ T C+ +PY
Sbjct: 607 LVAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSS-----------DPL------CMVTEYMENGDLNMFLSQ--REIESTLTHA-NNIPSVSIAD--------------------LLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPY 794 HSP 2 Score: 111.309 bits (277), Expect = 2.933e-24 Identity = 108/411 (26.28%), Postives = 186/411 (45.26%), Query Frame = 1
Query: 148 DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFP---LKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF---TTNVPKEEYP---------------TEKQGSDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
DD + S + D+ P AR + AWC ++ P+ +Y+Q+D + L L+ + T G N G F + L+Y R +G W ++N +++I GNV++ + + II R +R+IP+++ TVC++ +G + DG++ YS P+G I + FP L D YDG +E RK L G+GQL D ++ + + ++VGW+N +EM F+FD+ R + H N + IFSS F + I ++ + F D + +AR++ V L A +R F W++ +E+ F T +P ++ P T ++ D + +K S + N I ++T + L+ +I IL
Sbjct: 25 DDITASSQWYDSTGPQYARLNREEGE-----GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSR-DGHRWISWRNRFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTVCMRVELFGCAWQDGLMAYSSPEGQI--MMAPGFPITSLNDSTYDGPLERRK----LSGGLGQLADGVVGLDDFVESRQYRLWPGYDYVGWRNDGLGPAYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKL-HLISEWESEPVEFHTVIDDRNPSARYVTVPLKHRSATALRCRFYFADTWMMFSEISFQSVTIVLPTKKPPVLTPPSYEANSEIPETTQKTEDWTTPTKTGS----PEEGNTSILIGCLVTIILLLVVIIFLIL 418
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Match: ddr2l (discoidin domain receptor family, member 2, like [Source:ZFIN;Acc:ZDB-GENE-041210-162]) HSP 1 Score: 114.005 bits (284), Expect = 4.807e-25 Identity = 71/249 (28.51%), Postives = 118/249 (47.39%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++++ N ++++ C S D L C++ ++ G L+ F+ + R + S L +A NN P + L++++ QIS GM +L +HRDLATRNC++ L+I I+D M N + DY I Q LP++WM+WE++L G++++ SDVW+FGV W++ T C+ +PY
Sbjct: 619 LVAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSS-----------DPL------CMVTEYMENGDLNMFLSQ--REIESTLTHA-NNIPSVSIAD--------------------LLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPY 806 HSP 2 Score: 111.309 bits (277), Expect = 3.011e-24 Identity = 108/411 (26.28%), Postives = 186/411 (45.26%), Query Frame = 1
Query: 148 DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFP---LKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF---TTNVPKEEYP---------------TEKQGSDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
DD + S + D+ P AR + AWC ++ P+ +Y+Q+D + L L+ + T G N G F + L+Y R +G W ++N +++I GNV++ + + II R +R+IP+++ TVC++ +G + DG++ YS P+G I + FP L D YDG +E RK L G+GQL D ++ + + ++VGW+N +EM F+FD+ R + H N + IFSS F + I ++ + F D + +AR++ V L A +R F W++ +E+ F T +P ++ P T ++ D + +K S + N I ++T + L+ +I IL
Sbjct: 37 DDITASSQWYDSTGPQYARLNREEGE-----GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSR-DGHRWISWRNRFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTVCMRVELFGCAWQDGLMAYSSPEGQI--MMAPGFPITSLNDSTYDGPLERRK----LSGGLGQLADGVVGLDDFVESRQYRLWPGYDYVGWRNDGLGPAYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKL-HLISEWESEPVEFHTVIDDRNPSARYVTVPLKHRSATALRCRFYFADTWMMFSEISFQSVTIVLPTKKPPVLTPPSYEANSEIPETTQKTEDWTTPTKTGS----PEEGNTSILIGCLVTIILLLVVIIFLIL 430
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Match: BX088694.1 (discoidin domain receptor family, member 2, like [Source:NCBI gene;Acc:565333]) HSP 1 Score: 113.62 bits (283), Expect = 4.973e-25 Identity = 71/249 (28.51%), Postives = 118/249 (47.39%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++++ N ++++ C S D L C++ ++ G L+ F+ + R + S L +A NN P + L++++ QIS GM +L +HRDLATRNC++ L+I I+D M N + DY I Q LP++WM+WE++L G++++ SDVW+FGV W++ T C+ +PY
Sbjct: 597 LVAVKQLRADATSNARNDFLKEIKIMSRLNNPNIIQLLCVCVSS-----------DPL------CMVTEYMENGDLNMFLSQ--REIESTLTHA-NNIPSVSIAD--------------------LLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKISDFGMSRNLYSSDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPY 784 HSP 2 Score: 109.768 bits (273), Expect = 7.815e-24 Identity = 107/411 (26.03%), Postives = 186/411 (45.26%), Query Frame = 1
Query: 148 DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFP---LKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF---TTNVPKEEYP---------------TEKQGSDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
DD + S + D+ P AR + AWC ++ P+ +Y+Q+D + L L+ + T G N G F + L+Y R +G W ++N +++I GNV++ + + II R +R+IP+++ TVC++ +G + DG++ YS P+G I + FP L D YDG +E RK L G+GQL D ++ + + ++VGW+N +EM F+FD+ R + H N + IFSS F + I ++ + F D + +AR++ + L A +R F W++ +E+ F T +P ++ P T ++ D + +K S + N I ++T + L+ +I IL
Sbjct: 37 DDITASSQWYDSTGPQYARLNREEGE-----GAWCAAGQLQPSDVQYLQIDLRQLIFLTVVATQGRYARNSGIEFARKYRLEYSR-DGHRWISWRNRFGNEIIMGNVNTYDTVVRDLHPPIITRFLRLIPVTDAVHTVCMRVELFGCAWQDGLMAYSSPEGQI--MMAPGFPITSLNDSTYDGPLERRK----LSGGLGQLADGVVGLDDFVESRQYRLWPGYDYVGWRNDGLGPGYVEMEFQFDRQRNFTSMKVHSNNMFSMGVKIFSSVSCVFKL-HLISEWESEPVEFHTVIDDRNPSARYVTIPLKHRSATALRCRFYFADTWMMFSEISFQSVTIVLPTKKPPVLTPPSYEANSEIPETTQKTEDWTTPTKTGS----PEEGNTSILIGCLVTIILLLVVIIFLIL 430
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Match: ddr2l (discoidin domain receptor tyrosine kinase 2 like [Source:NCBI gene;Acc:779954]) HSP 1 Score: 119.398 bits (298), Expect = 1.467e-26 Identity = 79/308 (25.65%), Postives = 137/308 (44.48%), Query Frame = 1
Query: 2134 IIMEKLSKIDIE-------KMELQKLIGSGRYGSIKKGIYNG----------------SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+ ++ L+K DI ++ L++ +G G++G + G ++V VK + D + R FLK I + ++ N ++++G C ++ C+I ++ G L++F+ + R + S A NN P +S L+Y+AAQI+ GM +L +HRDLATRNC+VG +I + D M N + DY I Q LP++WM+WE++L G++++ SD W+FGV W++ + C+ +PY
Sbjct: 565 VTVDSLTKKDITVGEFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTARNDFLKEIKIISRLKHPNIIRLLGVC-----------------VRDDPLCMITEYMENGDLNQFLSQ--REIRSQFTKA-NNIPS--------------------VSRQNLLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTIKVADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTCSDAWAFGVTLWEMFSLCKEQPY 811 HSP 2 Score: 106.686 bits (265), Expect = 1.020e-22 Identity = 99/377 (26.26%), Postives = 174/377 (46.15%), Query Frame = 1
Query: 49 FVIFVLLTGFIFSQFLPSFRGKDTNYNL-INDLS---DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSAR--FEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
F + LL+G +P+ Y L ++D + +D + S + ++ P AR + + AWCP + P +Y+Q+D +L ++ + T G G F + +DY R NG W +++ +++ GNVD + + + IIAR IR+IP++ + TVC++ YG ++DG+ YS+P+G+ + I F L D YDG +E R+ G+GQL D I + V +++GW+N R +E+ F FD+ R + H N K + IF A F+ + GE A+ + D K +AR++ + L + F W++ +E+ F +++
Sbjct: 5 FFLLALLSGRAKCAVIPA----SCRYALGMHDRTIRDEDIIASSQWYESTGPQYARLQRE-----EGDGAWCPAGLLQPEDVQYLQIDLHELHFITLIGTQGRHARATGKEFARAYRVDYSR-NGGRWLSWRDHQGQQVMRGNVDEYEVVLADLRPPIIARYIRVIPVTKVPMTVCMRVELYGCKWSDGLTSYSVPEGETYIAPGQPIAF-LNDSTYDGYLEKRRQFG----GLGQLTDGIHGLDDFTQSLQYRVWPGYDYIGWRNDSAPRGYVEVEFHFDRPRNFSLMKVHCNNLFSKGVKIFQKAECLFKPRLEGEWE---AEPVVVLMVVDDKNPSARFVTIPLRQRVGSAILCRFYFADAWMMFSEISFESDM 363
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Match: ddr2l (discoidin domain receptor tyrosine kinase 2 like [Source:NCBI gene;Acc:779954]) HSP 1 Score: 119.013 bits (297), Expect = 1.656e-26 Identity = 77/308 (25.00%), Postives = 135/308 (43.83%), Query Frame = 1
Query: 2134 IIMEKLSKIDIE-------KMELQKLIGSGRYGSIKKGIYNG----------------SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+ ++ L+K DI ++ L++ +G G++G + G ++V VK + D + R FLK I + ++ N ++++G C ++ C+I ++ G L++F+ + R + S A N S + L+Y+AAQI+ GM +L +HRDLATRNC+VG +I + D M N + DY I Q LP++WM+WE++L G++++ SD W+FGV W++ + C+ +PY
Sbjct: 541 VTVDSLTKKDITVGEFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTARNDFLKEIKIISRLKHPNIIRLLGVC-----------------VRDDPLCMITEYMENGDLNQFLSQ--REIRSQFTKANNIPSVSRQN---------------------LLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTIKVADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTCSDAWAFGVTLWEMFSLCKEQPY 787 HSP 2 Score: 106.686 bits (265), Expect = 9.966e-23 Identity = 103/388 (26.55%), Postives = 173/388 (44.59%), Query Frame = 1
Query: 148 DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSAR--FEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF-------------TTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLIC 1239
+D + S + ++ P AR + + AWCP + P +Y+Q+D +L ++ + T G G F + +DY R NG W +++ +++ GNVD + + + IIAR IR+IP++ + TVC++ YG ++DG+ YS+P+G+ + I F L D YDG +E R+ G+GQL D I + V +++GW+N R +E+ F FD+ R + H N K + IF A F+ + GE A+ + D K +AR++ + L + F W++ +E+ F T VP +P E T S+ N P S+ + L+ C
Sbjct: 28 EDIIASSQWYESTGPQYARLQRE-----EGDGAWCPAGLLQPEDVQYLQIDLHELHFITLIGTQGRHARATGKEFARAYRVDYSR-NGGRWLSWRDHQGQQVMRGNVDEYEVVLADLRPPIIARYIRVIPVTKVPMTVCMRVELYGCKWSDGLTSYSVPEGETYIAPGQPIAF-LNDSTYDGYLEKRRQFG----GLGQLTDGIHGLDDFTQSLQYRVWPGYDYIGWRNDSAPRGYVEVEFHFDRPRNFSLMKVHCNNLFSKGVKIFQKAECLFKPRLEGEWE---AEPVVVLMVVDDKNPSARFVTIPLRQRVGSAILCRFYFADAWMMFSEISFESGKCSLPAALSHTHCVPPHRHPNETTFPFTISRPVVNP--PESRTSVLIGC 399
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Match: ddr2l (discoidin domain receptor tyrosine kinase 2 like [Source:NCBI gene;Acc:779954]) HSP 1 Score: 118.242 bits (295), Expect = 2.651e-26 Identity = 77/308 (25.00%), Postives = 135/308 (43.83%), Query Frame = 1
Query: 2134 IIMEKLSKIDIE-------KMELQKLIGSGRYGSIKKGIYNG----------------SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+ ++ L+K DI ++ L++ +G G++G + G ++V VK + D + R FLK I + ++ N ++++G C ++ C+I ++ G L++F+ + R + S A N S + L+Y+AAQI+ GM +L +HRDLATRNC+VG +I + D M N + DY I Q LP++WM+WE++L G++++ SD W+FGV W++ + C+ +PY
Sbjct: 504 VTVDSLTKKDITVGEFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTARNDFLKEIKIISRLKHPNIIRLLGVC-----------------VRDDPLCMITEYMENGDLNQFLSQ--REIRSQFTKANNIPSVSRQN---------------------LLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTIKVADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTCSDAWAFGVTLWEMFSLCKEQPY 750 HSP 2 Score: 108.227 bits (269), Expect = 3.545e-23 Identity = 101/388 (26.03%), Postives = 174/388 (44.85%), Query Frame = 1
Query: 148 DDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSAR--FEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF-------------TTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLIC 1239
+D + S + ++ P AR + + AWCP + P +Y+Q+D +L ++ + T G G F + +DY R NG W +++ +++ GNVD + + + IIAR IR+IP++ + TVC++ YG ++DG+ YS+P+G+ + I F L D YDG +E R+ G+GQL D I + V +++GW+N R +E+ F FD+ R + H N K + IF A F+ + GE A+ + D K +AR++ + L + F W++ +E+ F T VP +P + + + S+P P S+ + L+ C
Sbjct: 28 EDIIASSQWYESTGPQYARLQRE-----EGDGAWCPAGLLQPEDVQYLQIDLHELHFITLIGTQGRHARATGKEFARAYRVDYSR-NGGRWLSWRDHQGQQVMRGNVDEYEVVLADLRPPIIARYIRVIPVTKVPMTVCMRVELYGCKWSDGLTSYSVPEGETYIAPGQPIAF-LNDSTYDGYLEKRRQFG----GLGQLTDGIHGLDDFTQSLQYRVWPGYDYIGWRNDSAPRGYVEVEFHFDRPRNFSLMKVHCNNLFSKGVKIFQKAECLFKPRLEGEWE---AEPVVVLMVVDDKNPSARFVTIPLRQRVGSAILCRFYFADAWMMFSEISFESGKCSLPAALSHTHCVPPHRHPNGAKTTFPFTISRPVVNPPESRTSVLIGC 401
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Match: DDR2 (discoidin domain receptor tyrosine kinase 2 [Source:NCBI gene;Acc:100497889]) HSP 1 Score: 115.161 bits (287), Expect = 2.593e-25 Identity = 70/254 (27.56%), Postives = 112/254 (44.09%), Query Frame = 1
Query: 2239 SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRH----SRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
++V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ R P ++ I+ T+ L ++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+F V W+ LTFC+ +PY
Sbjct: 564 TLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------IAEDPLCMITEYMENGDLNQFLSRQQPEGGLPAATLPISYTD-----------------------------LRHMAAQIASGMKYLSSLNFVHRDLATRNCLVGRNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFAVTLWETLTFCREQPY 750 HSP 2 Score: 101.679 bits (252), Expect = 3.348e-21 Identity = 81/305 (26.56%), Postives = 148/305 (48.52%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ-IKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
AWCP+ V P E++Q+D + L ++ + T G G G F F ++Y R +G+ W ++N ++++GNV+ ++ + + I+AR +R IP+++ + VCL+ YG + DG+V Y+ P G F + + L D IYDG + G+GQL D + + + + ++VGW N N +E++F FD++R + H N K + IF + F + A +I+ D +AR++ V L + A+ ++ F W++ +E+ F ++
Sbjct: 36 AWCPEMPVDPEELTEFLQIDLRVLHFITLVGTQGRHAGGHGNEFAQMFKINYSR-DGTRWISWRNRHGRQVLDGNVNPYDIVLKDLEPPIVARFLRFIPVTDHSMNVCLRVELYGCVWLDGLVSYNAPSGQQFLLPEGYAIYLNDTIYDGAIGYS----MTEGLGQLTDGVSGLDDFTLTHEYHMWPGYDYVGWSNESFSNGYVEIVFEFDRIRNFTTMKVHCNNMFSKGVKIFKDVQCFFRSDANEWE--ANSISSTLVLDDANPSARYVTVQLHNHMARAIKCHYYFADSWMMFSEITFQSDA 333
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Match: DDR2 (discoidin domain receptor tyrosine kinase 2 [Source:NCBI gene;Acc:100497889]) HSP 1 Score: 114.775 bits (286), Expect = 3.606e-25 Identity = 70/254 (27.56%), Postives = 112/254 (44.09%), Query Frame = 1
Query: 2239 SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRH----SRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
++V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ R P ++ I+ T+ L ++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+F V W+ LTFC+ +PY
Sbjct: 553 TLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------IAEDPLCMITEYMENGDLNQFLSRQQPEGGLPAATLPISYTD-----------------------------LRHMAAQIASGMKYLSSLNFVHRDLATRNCLVGRNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFAVTLWETLTFCREQPY 739 HSP 2 Score: 98.9821 bits (245), Expect = 2.866e-20 Identity = 81/303 (26.73%), Postives = 146/303 (48.18%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ-IKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTT 1128
AWCP+ V P E++Q+D + L ++ + T G G G F F ++Y R +G+ W ++N ++++GNV+ ++ + + I+AR +R IP+++ + VCL+ YG + DG+V Y+ P G F + + L D IYDG G+GQL D + + + + ++VGW N N +E++F FD++R + H N K + IF + F + A +I+ D +AR++ V L + A+ ++ F W++ +E+ F +
Sbjct: 36 AWCPEMPVDPEELTEFLQIDLRVLHFITLVGTQGRHAGGHGNEFAQMFKINYSR-DGTRWISWRNRHGRQVLDGNVNPYDIVLKDLEPPIVARFLRFIPVTDHSMNVCLRVELYGCVWLDGLVSYNAPSGQQFLLPEGYAIYLNDTIYDGA----------IGLGQLTDGVSGLDDFTLTHEYHMWPGYDYVGWSNESFSNGYVEIVFEFDRIRNFTTMKVHCNNMFSKGVKIFKDVQCFFRSDANEWE--ANSISSTLVLDDANPSARYVTVQLHNHMARAIKCHYYFADSWMMFSEITFQS 325
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Match: Ddr2 (discoidin domain receptor family, member 2 [Source:MGI Symbol;Acc:MGI:1345277]) HSP 1 Score: 121.709 bits (304), Expect = 1.644e-27 Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ RH P+SS +AT + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------ITEDPLCMITEYMENGDLNQFLSRH-EPLSSCSSDATVSYAN-------------------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 788 HSP 2 Score: 100.908 bits (250), Expect = 4.477e-21 Identity = 82/306 (26.80%), Postives = 149/306 (48.69%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
AWCP+ V P+ KE++Q+D + L ++ + T G G G F + ++Y R +GS W ++N ++++GN + ++ + + I+AR +R+IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A + F D +AR++ V L A ++ F W++ +E+ F ++
Sbjct: 71 AWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTA--VYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDA 368
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Match: Ddr2 (discoidin domain receptor family, member 2 [Source:MGI Symbol;Acc:MGI:1345277]) HSP 1 Score: 121.709 bits (304), Expect = 1.644e-27 Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ RH P+SS +AT + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------ITEDPLCMITEYMENGDLNQFLSRH-EPLSSCSSDATVSYAN-------------------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 788 HSP 2 Score: 100.908 bits (250), Expect = 4.477e-21 Identity = 82/306 (26.80%), Postives = 149/306 (48.69%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
AWCP+ V P+ KE++Q+D + L ++ + T G G G F + ++Y R +GS W ++N ++++GN + ++ + + I+AR +R+IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A + F D +AR++ V L A ++ F W++ +E+ F ++
Sbjct: 71 AWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTA--VYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDA 368
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Match: Ddr2 (discoidin domain receptor family, member 2 [Source:MGI Symbol;Acc:MGI:1345277]) HSP 1 Score: 121.709 bits (304), Expect = 1.644e-27 Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ RH P+SS +AT + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------ITEDPLCMITEYMENGDLNQFLSRH-EPLSSCSSDATVSYAN-------------------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 788 HSP 2 Score: 100.908 bits (250), Expect = 4.477e-21 Identity = 82/306 (26.80%), Postives = 149/306 (48.69%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
AWCP+ V P+ KE++Q+D + L ++ + T G G G F + ++Y R +GS W ++N ++++GN + ++ + + I+AR +R+IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A + F D +AR++ V L A ++ F W++ +E+ F ++
Sbjct: 71 AWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTA--VYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDA 368
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Match: Ddr1 (discoidin domain receptor family, member 1 [Source:MGI Symbol;Acc:MGI:99216]) HSP 1 Score: 116.316 bits (290), Expect = 9.453e-26 Identity = 78/288 (27.08%), Postives = 128/288 (44.44%), Query Frame = 1
Query: 2143 EKLSKIDIEKMEL------QKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
EKL + ++ L Q L+ S S+ KG + +V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ +R + + + SD T L+++ AQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 612 EKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKG--HPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFL--SARQLENKATQGLSGDTESDQGPTISYPM--------------LLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPF 843 HSP 2 Score: 95.1301 bits (235), Expect = 3.375e-19 Identity = 76/315 (24.13%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRR----GIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
++S+ D AWCP V P +EY+QVD + L ++ + T G G G F + L Y R +G W +K+ ++I GN D + + ++AR +R P ++ +VCL+ YG + DG++ Y+ P G + ++ L D YDG G+ L D ++ ++VGW N +EM F FD++R + + H N + F G + + + + L AR + V L +F++ F W++ +E+ F ++V
Sbjct: 61 RHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPG---YDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWE-GEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDV 370
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Match: Ddr1 (discoidin domain receptor family, member 1 [Source:MGI Symbol;Acc:MGI:99216]) HSP 1 Score: 116.316 bits (290), Expect = 9.453e-26 Identity = 78/288 (27.08%), Postives = 128/288 (44.44%), Query Frame = 1
Query: 2143 EKLSKIDIEKMEL------QKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
EKL + ++ L Q L+ S S+ KG + +V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ +R + + + SD T L+++ AQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 612 EKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKG--HPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFL--SARQLENKATQGLSGDTESDQGPTISYPM--------------LLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPF 843 HSP 2 Score: 95.1301 bits (235), Expect = 3.375e-19 Identity = 76/315 (24.13%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRR----GIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
++S+ D AWCP V P +EY+QVD + L ++ + T G G G F + L Y R +G W +K+ ++I GN D + + ++AR +R P ++ +VCL+ YG + DG++ Y+ P G + ++ L D YDG G+ L D ++ ++VGW N +EM F FD++R + + H N + F G + + + + L AR + V L +F++ F W++ +E+ F ++V
Sbjct: 61 RHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPG---YDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWE-GEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDV 370
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Match: sp|Q16832|DDR2_HUMAN (Discoidin domain-containing receptor 2 OS=Homo sapiens OX=9606 GN=DDR2 PE=1 SV=2) HSP 1 Score: 122.094 bits (305), Expect = 8.979e-27 Identity = 77/249 (30.92%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N + ++ C TD+ P C+I ++ G L++F+ RH P SS+ SD S + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVC---ITDD----PL----------CMITEYMENGDLNQFLSRHEPPNSSS----------SDVRTVSYTN---------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 789 HSP 2 Score: 100.523 bits (249), Expect = 4.728e-20 Identity = 89/349 (25.50%), Postives = 160/349 (45.85%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVP----KEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVI 1251
AWCP+ V P+ KE++Q+D L ++ + T G G G F + ++Y R +G+ W ++N ++++GN + ++ + + I+AR +R IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A I+F D +AR++ V L A ++ F W++ +E+ F ++ E PT T + M N ++ C++
Sbjct: 71 AWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNA--ISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTY-----DPMLKVDDSNTRILIGCLV 406
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Match: sp|Q62371|DDR2_MOUSE (Discoidin domain-containing receptor 2 OS=Mus musculus OX=10090 GN=Ddr2 PE=1 SV=2) HSP 1 Score: 121.709 bits (304), Expect = 1.150e-26 Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C + C+I ++ G L++F+ RH P+SS +AT + L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ TFCQ +PY
Sbjct: 604 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVC-----------------ITEDPLCMITEYMENGDLNQFLSRH-EPLSSCSSDATVSYAN-------------------------LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 788 HSP 2 Score: 100.908 bits (250), Expect = 3.132e-20 Identity = 82/306 (26.80%), Postives = 149/306 (48.69%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLDNGNDGF-FVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI--YQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDK-NRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
AWCP+ V P+ KE++Q+D + L ++ + T G G G F + ++Y R +GS W ++N ++++GN + ++ + + I+AR +R+IP+++ + VC++ YG + DG+V Y+ P G F + I + L D +YDG + G+GQL D + + + V ++VGW+N N IE++F FD++R + H N K + IF + F + A + F D +AR++ V L A ++ F W++ +E+ F ++
Sbjct: 71 AWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSR-DGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIY-LNDSVYDGAVGYS----MTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTA--VYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDA 368
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Match: sp|Q95ZV7|DDRB_CAEEL (Discoidin domain-containing receptor tyrosine kinase B OS=Caenorhabditis elegans OX=6239 GN=ddr-2 PE=1 SV=1) HSP 1 Score: 119.398 bits (298), Expect = 5.959e-26 Identity = 95/309 (30.74%), Postives = 157/309 (50.81%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----------NFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRL--QWIVLTEVQFTTN 1131
AWCPKN++ SKE++Q+ F ++ + T G D+G + + F + Y R + + W YK++ + + I N D+ + IIARRIRI+P+SN T+TVC++ +G F+D +V Y++ QGD+ Q D YDG + N L GIG+L D GEV +VGW+ +N +++ F F ++R + G+ H N+ KK+ FSSA FSI G+ + + F + D + + RW+ + +++ AK ++ L F W+ ++EV F +N
Sbjct: 67 AWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDL----QSGISYHDFSYDG--NLANSPHLTGGIGKLYD-------------GEVGKNNVFVNHHKWVGWRR-KRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTI--VHFNNPEDTESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESN 353 HSP 2 Score: 99.7525 bits (247), Expect = 7.637e-20 Identity = 81/315 (25.71%), Postives = 132/315 (41.90%), Query Frame = 1
Query: 2122 DYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF-----CVPQNLTNIDSTANYVKCLS 3051
DY E+ L +I +K+ IG G +G + V VK ++ + SF + I L + N V++VG C + KP I CI M++ G L +I ++ P TS C I I Q++ G+++LE +HRD+A RNC+V ++ I D M + + ++Y + + LP++WM+WEA+L G++S+ SDVW FGV W++ + C +PY V +NL ++ ST + + LS
Sbjct: 510 DYGEVYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLENRKVAVKKLH-GISQADEFSFHREIRVLGSLKHPNVVEVVGVC---------------TIQKP-ILCI-MEYMENGDLKSYILKN---------------PTIQTS-------------------QC-ISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKV---------------------EGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLS 750
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Match: sp|Q08345|DDR1_HUMAN (Epithelial discoidin domain-containing receptor 1 OS=Homo sapiens OX=9606 GN=DDR1 PE=1 SV=1) HSP 1 Score: 119.013 bits (297), Expect = 1.059e-25 Identity = 69/249 (27.71%), Postives = 111/249 (44.58%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ H +A PG + L+++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 651 LVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFLSAHQLEDKAA-----EGAPGDGQAAQGPTISYPM-----------LLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 845 HSP 2 Score: 95.1301 bits (235), Expect = 2.063e-18 Identity = 80/317 (25.24%), Postives = 137/317 (43.22%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG----IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHN--ADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
++S+ D AWCP V P +EY+QVD + L ++ + T G G G F + L Y R +G W +K+ ++I GN D + + ++AR +R P ++ +VCL+ YG + DG++ Y+ P G + + + L D YDG L G+ L D ++ ++VGW N + +EM F FD++R + + H N + F G + + +HN +L AR + V L A+F++ F W++ +E+ F ++V
Sbjct: 60 RHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVY-LNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPG---YDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAM---AWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDV 368
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Match: sp|Q7YR43|DDR1_PANTR (Epithelial discoidin domain-containing receptor 1 OS=Pan troglodytes OX=9598 GN=DDR1 PE=3 SV=1) HSP 1 Score: 119.013 bits (297), Expect = 1.081e-25 Identity = 69/249 (27.71%), Postives = 111/249 (44.58%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK + + ++ N ++++G C QD L C+I + G L++F+ H +A PG + L+++AAQI+ GM +L +HRDLATRNC+VG +I I D M N + DY + Q LP++WM+WE +L G++++ SDVW+FGV W++L C+ +P+
Sbjct: 647 LVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC------------VQDDPL-----CMITDYMENGDLNQFLSAHQLEDKAA-----EGAPGDGQAAQGPTISYPM-----------LLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 841 HSP 2 Score: 94.3597 bits (233), Expect = 4.138e-18 Identity = 79/309 (25.57%), Postives = 133/309 (43.04%), Query Frame = 1
Query: 232 DSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG----IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHN--ADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV 1134
D AWCP V P +EY+QVD + L ++ + T G G G F + L Y R +G W +K+ ++I GN D + + ++AR +R P ++ +VCL+ YG + DG++ Y+ P G + + + L D YDG L G+ L D ++ ++VGW N + +EM F FD++R + + H N + F G + + +HN +L AR + V L A+F++ F W++ +E+ F ++V
Sbjct: 64 DGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSR-DGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVY-LNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPG---YDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAM---AWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDV 364
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Match: A0A2S2QVE2 (Epithelial discoidin domain-containing receptor 1 OS=Sipha flava OX=143950 GN=DDR1_0 PE=4 SV=1) HSP 1 Score: 164.851 bits (416), Expect = 1.445e-37 Identity = 106/380 (27.89%), Postives = 196/380 (51.58%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXX---XXXXXXGEVNFVGWQNFDKN-RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEY----------PTEKQGSDTRSKS--KPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
+N++ R AWCPK+ V + KE+++V+ +++ ++ + T G NG + F ++Y R W RY+N T H ++ GN+++ I A +IR +P S T+ VC++ YG + DG++ YSMPQGD + ++ D YDG D+ L+RG+GQL D + + +VGW+N + + IE+ F FDK+R GV + N +K++ +FS A FS+GG++Y ++ +T+ + D +T+R + + L +FV++ L F +WI+++E+ F ++V + + PT+K GS + ++ +P PT+K + +I + ++ ++++ I
Sbjct: 58 QNARVRTEKEGGAWCPKDPVTNDIKEWLEVNLHEVRVITAVETQGRFGNGQGQEYTETFVIEYWRPKLGKWVRYRNITGHVILTGNINTYLEHKQDLNPPIWASKIRFLPHSYHTRQVCMRVELYGCPWTDGILSYSMPQGDKRST---EWEFYDSTYDGYW----DDELQRGLGQLTDGKVGPDHFRPAYYDTEKNQGWVGWRNDTRGGQAIEIKFEFDKIREFIGVHIYCNNQFQKDVQVFSEASILFSVGGKVY--SSEPLTYTYMEDRIFETSRNVSIKLHRRVGRFVKLRLSFAAKWIMISEITFDSDVAQGNFSEEIISPPDLPTQKDGSAAKDQNPLRPELSMPTAKDEDQTYMAIIIGVLMAVIILLAVAIF 428 HSP 2 Score: 117.857 bits (294), Expect = 7.579e-23 Identity = 70/249 (28.11%), Postives = 111/249 (44.58%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + R + L + +N +++G C E P C++M+++ G L++F++ H PV +A N P S + + CL+Y+A QI+ GM +LE +HRDLATRNC+VG + I+D DN + DY ++ + LP++WM+WE+ +YS+KSDVWSF V W++L + RPY
Sbjct: 659 LVAVKFFSPALSEKERAELQNDVRILAGLEDQNIARVLGICSI-------EQPL----------CVVMEYSEHGDLNQFLKMHV-PVEAA-----RNLPPSVKTLSFQ----------------CLLYLATQIASGMRYLESLNFVHRDLATRNCLVGKAYKVKISDFGTDNESYSSDYYKLDG---------------------KIGLPIRWMAWESAFLDKYSTKSDVWSFAVTLWEILHLAKSRPY 847
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Match: A0A2H8TKL8 (Discoidin domain-containing receptor 2 OS=Melanaphis sacchari OX=742174 GN=DDR2_1 PE=4 SV=1) HSP 1 Score: 162.54 bits (410), Expect = 7.171e-37 Identity = 111/382 (29.06%), Postives = 195/382 (51.05%), Query Frame = 1
Query: 208 KNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXX----XXXGEVNFVGWQNFDKN-RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPK----------EEYPTEKQGS---DTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
+N++ R AWCPK V E+++V+ ++ ++ + T G NG F F +DY R W RY+N T H+++ GN+++ + I A +IR +P S T+ VC++ YG + DG++ YSMPQGD ++ D YDG D+ L+RG+GQL D I + + G+ +VGW+N +N + IE+ F FDKVR GV + N +K++ +FS A FS+GG++Y ++ +T+ + D +T+R + + L +F+++ L F +WI+++E+ F ++V + E P +K GS D + +P PT+K + +I + ++ ++++ I
Sbjct: 59 QNARVRTEREGGAWCPKEPVTREPTEWLEVNLHVVRVITSVETQGRFGNGQGQEFTEAFLIDYWRPKLGKWVRYRNITGHEILIGNINTYLEHKQELNPPIWASKIRFLPHSYHTRQVCMRVELYGCPWTDGILSYSMPQGDK---RNPEWEFYDSTYDGYW----DDELQRGLGQLTDGKIGQENFRMGYYDSERGQ-GWVGWRNDTRNGQAIEIKFEFDKVREFTGVHIYCNNQFQKDVQVFSEASILFSVGGKVY--SSEPLTYTYMEDRIFETSRNVSIKLHRRVGRFIKLRLSFAAKWIMISEITFDSDVAQGNFSEESAIPPEPPIQKNGSTMKDHQDPLRPELPVPTAKDEDQTYMAVIIGVLMAVIILLAVAIF 430 HSP 2 Score: 118.627 bits (296), Expect = 3.862e-23 Identity = 75/284 (26.41%), Postives = 124/284 (43.66%), Query Frame = 1
Query: 2137 IMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
++ KLS+ + + + + G Y S K +V VK + R + L + +N +++G C E P C++M+++ G L++F++ H + A N P + + + CL+Y+A QI+ GM +LE +HRDLATRNC+VG + I+D DN + DY ++ ++ LP++WMSWE+ +YS+KSDVWSF V W++L + RPY
Sbjct: 626 MLSKLSEGNYGAIYVAEADGINEYSS--KMTLGKRLVAVKFFSPALSEKERAELQNDVRILAGLEDQNIARVLGVCT-------SEQPL----------CVVMEYSEHGDLNQFLKTH------VPVEAARNLPPTVKTLSFQ----------------CLLYLATQIASGMRYLESLNFVHRDLATRNCLVGKAYKVKISDFGTDNEAYAADYYKLDG---------------------NLGLPVRWMSWESAFLDKYSTKSDVWSFAVTLWEILHLAKSRPY 847
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Match: J9JU75 (Uncharacterized protein OS=Acyrthosiphon pisum OX=7029 GN=100162767 PE=4 SV=2) HSP 1 Score: 160.229 bits (404), Expect = 4.390e-36 Identity = 115/403 (28.54%), Postives = 201/403 (49.88%), Query Frame = 1
Query: 148 DDAFSCSSFR-DNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXX----XXXXXXXXXGEVNFVGWQNFDKN-RKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPK----------EEYPTEKQGS---DTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
DD + SSF N P +N++ R AWCPK V E+++V+ ++ ++ + T G NG F F +DY R W RY+N T +++ GN+++ + I A +IR +P S T+ VC++ YG + DG++ YSMPQGD + ++ D YDG D+ L+RG+GQL D + G+ +VGW+N +N + IE+ F FDKVR GV + N +K++ +FS A FS+GG++Y ++ +T+ + D +++R + + L +F+++ L F +WI+++E+ F ++V + E P +K GS D + +P PT+K + +I + ++ ++++ I
Sbjct: 43 DDLTASSSFEIGNVGP-----QNARVRTEREGGAWCPKEPVTREPTEWLEVNLHVVRVITSVETQGRFGNGQGQEFTEAFLIDYWRPKLGKWVRYRNITGQEILIGNINTYLEHKQELNPPIWASKIRFLPHSYHTRQVCMRVELYGCPWTDGILSYSMPQGDKRSP---EWEFYDSTYDGYW----DDELQRGLGQLTDGKVGLDNFRMGYYDTERGQ-GWVGWRNDTRNGQAIEIKFEFDKVREFTGVHIYCNNQFQKDVQVFSEASILFSVGGKVY--SSEPLTYTYMEDRIFESSRNVSIKLHRRVGRFIKLRLSFAAKWIMISEITFDSDVAQGNFSEESVVLTEPPIQKDGSAMKDHQDPLRPELPIPTAKDEDQTYMAIIIGVLMAVIILLAVAIF 430 HSP 2 Score: 116.701 bits (291), Expect = 1.527e-22 Identity = 77/285 (27.02%), Postives = 125/285 (43.86%), Query Frame = 1
Query: 2170 KMELQKLIGSGRYGSI----KKGI--YNGSV------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
++ + + G YG+I GI YN + V VK + R + L + +N +++G C E P C++M+++ G L++F++ H PV +A N P + + + CL+Y+A QI+ GM +LE +HRDLATRNC+VG + I+D DN + DY ++ ++ LP++WMSWE+ +YS+KSDVWSF V W++L + RP+
Sbjct: 626 RLRMLSKLSEGNYGAIYVAEADGINEYNSKITLGKRLVAVKFFSPALSEKERAELQNDVRILAGLEDQNIARVLGVCTV-------EQPL----------CVVMEYSEHGDLNQFLKTHV-PVEAA-----RNLPPTVKTLSFQ----------------CLLYLATQIASGMRYLESLNFVHRDLATRNCLVGKAYKVKISDFGTDNEAYSADYYKLDG---------------------NLGLPVRWMSWESAFLDKYSTKSDVWSFAVTLWEILHLAKSRPF 850
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Match: A0A3R7CV08 (Discoidin domain-containing receptor 2 OS=Clonorchis sinensis OX=79923 GN=Ddr2 PE=4 SV=1) HSP 1 Score: 160.614 bits (405), Expect = 4.422e-36 Identity = 109/345 (31.59%), Postives = 165/345 (47.83%), Query Frame = 1
Query: 142 LSDDAFSCSSFRDNFFPYLAREKNSK--NRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI-YQIKFPLKDRIYDG------IEHRKNDNVLRR------GIGQLMDXXXXXXXXXXXXXGEVNFVGW---QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF 1122
L AFS SS N A + N +S AWCP + E++Q++F LK + L T G N N +V F L YQR+ G W+ Y+ KL+ N +S+ + I+ + R + +CL+ YG F DGV+EYS+P+GD++ + + L D YDG + +++ R GIG LMD E S+ + N VGW Q+ + I M+F FD+VR + H LN L+ +++F A +FSIGG Y + + I ++ D + + ARW+ + L +FVR+TL F WIVL+E+ F
Sbjct: 68 LPPSAFSASSVYKNQPESQAHKANLVVFASQEESSGAWCPAKPIQAERSEWLQIEFDTLKIMRVLFTEGRAN-NQNAYVPAFLLRYQRQTGHRWYDYRMRNGTKLLYANNNSQTIAISLDPPIVAKRFRLYPYNELEPRFMCLRIAVYGSVFTDGVIEYSIPEGDVYRMDPRQHVSLNDTSYDGSWIIPPVTSNNPESITSRRAYFYGGIGLLMDKQYYEGSLPETADNH-NVVGWFRRQHSRPSEHIMMLFCFDQVRNFTELRLHALNSLRY-VALFRRALIQFSIGGRYYDRKSAAILYEGRRDTQSRQARWVSIPLDHRIGRFVRITLWFDYDWIVLSEITF 409
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Match: A0A4E0RRX0 (Discoidin domain-containing receptor 2 OS=Fasciola hepatica OX=6192 GN=D915_000296 PE=4 SV=1) HSP 1 Score: 158.688 bits (400), Expect = 1.869e-35 Identity = 108/373 (28.95%), Postives = 173/373 (46.38%), Query Frame = 1
Query: 142 LSDDAFSCSSFRDNFFPYLAREKNSK--NRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTI-YQIKFPLKDRIYDG-------------------IEHRKNDNV-LRRGIGQLMDXXXXXXXXXXXXXGEVNFVGW---QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTT-NVPKEEYPTEKQGSDTR 1179
L+ AFS SS +N + A + N +S AWCP V E++QVDF K ++ L T G + F SF + YQR++G W+ Y+ KL+ N ++ + + R + +CL+ YG F+DGVVEY++P+GD++ + ++ PL D YDG + + + L G+G LMD + + G N VGW Q+ + ++++IF FD++R FH+LN L +++F A +FS+GG+ + + D+ + ARW+ V L +F+R+TL F WIVL+EV F + + + PTEK R
Sbjct: 58 LAPAAFSASSVYNNQPEFQAHKANLVVFASQEESSGAWCPAVPVQNRLTEWLQVDFDTAKLMAVLFTEGRATSPNAFVPSFL-IRYQRQDGQRWYDYRMRNGTKLLHANHNALTVATRLDPPIVAKRFRLYPYNELEPRLMCLRLAVYGEAFDDGVVEYTIPEGDVYRMDPRLHVPLNDSSYDGWWTNTPGSSDLATWPGFKTLSNSADRRAYLHGGLGLLMDKQYYDGPLPEPE-GSHNVVGWFRRQHSTPSGRVQLIFAFDQIRNFTEARFHVLNSLNY-VAVFQRALIQFSVGGQHFNRHNPPALLDVRRDIHNRQARWVTVPLEHRVGRFLRITLWFDYDWIVLSEVGFDSYPILEHTVPTEKASDPIR 427
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Match: ENSAMXT00000019857.2 (discoidin domain-containing receptor 2-like [Source:NCBI gene;Acc:103025914]) HSP 1 Score: 127.487 bits (319), Expect = 2.084e-29 Identity = 82/296 (27.70%), Postives = 130/296 (43.92%), Query Frame = 1
Query: 2149 LSKIDIEKMELQKLIGSGRYGSI---------------KKGIYNGSVVV-VKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L + EK+ ++ +G G++G + + G+ N ++V VK + D + R FLK I + ++ N ++++ C ++ C+I ++ G L+KF+ RH S + DTS T LI +A QI+ GM +L +HRDLATRNC+VG +I I D M N ++ DY I Q LP++WMSWE++L G+++ SDVW+FGV W+ LT C+ +PY
Sbjct: 549 LEEFPREKLTFKEKLGEGQFGEVHLCEANGMQDFMKEDEDGVENEPILVAVKTLREDATKNTRNDFLKEIRIMSRLRDPNIIRLLAVC-----------------VESDPLCMITEYMENGDLNKFLSRHKLQDS--------GEEQKDTSSTISYST--------------LIRMATQIASGMKYLSSLNFVHRDLATRNCLVGTNYTIKIADFGMSRNLYRGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWETLTLCKEQPY 784 HSP 2 Score: 105.531 bits (262), Expect = 1.313e-22 Identity = 93/348 (26.72%), Postives = 158/348 (45.40%), Query Frame = 1
Query: 232 DSPQAWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF--------TTNVPKEE-YPTEKQGSDTRSKSKPNSMFPTSKINN 1227
D AWCP S KE++Q+D + L ++ + T G +G F + + Y R +G W + + ++I+GN + + + + IIAR +R +P+S+ + TVC++ YG + DG+V YS P G T + L D +YDG D+ + G+GQL D ++ V ++VGW N + +EM+F FD+VR + H N + F A F + A+ ++FK AD +AR++ V L A ++ F W++ +E+ F T+ +P++ +P+ G D PT KI++
Sbjct: 63 DGDGAWCPDVVAEAKSLKEFLQIDLRTLHFVTLVGTQGRHADGMGNEFAQSYRIKYSR-DGVRWVSWHDRNGGQVIDGNKNPYEVVLKDLEPPIIARFVRFMPVSDPSMTVCMRVELYGCEWLDGLVSYSAPVGQEMTFQNLHVYLNDTVYDGTV----DHSMTEGLGQLTDGSWGLDNFTQSQVYGVWPGYDYVGWTNASFPSGSVEMVFEFDRVRNFTSMKVHCNNMYTSGVRAFQQAVCYFRSESDWE---ARPVSFKPEADNTNTSARFVTVALGHRMASAIKCRFAFSDAWMMFSEIAFQSGTAVYNTSLIPRKRGHPSAHPGGD-----------PTHKIDD 391
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Match: ddr2a (discoidin domain receptor tyrosine kinase 2 [Source:NCBI gene;Acc:103037878]) HSP 1 Score: 120.168 bits (300), Expect = 4.572e-27 Identity = 75/249 (30.12%), Postives = 116/249 (46.59%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C S D L C+I ++ G L++F+ RH +I +N P +S++ L ++A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W+ LTFC+ +PY
Sbjct: 616 LVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCMSS-----------DPL------CMITEYMENGDLNQFLSRHE---PEGMIALLSNAP--------------------TVSYNNLHHMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETLTFCKEQPY 803 HSP 2 Score: 98.9821 bits (245), Expect = 1.478e-20 Identity = 84/326 (25.77%), Postives = 149/326 (45.71%), Query Frame = 1
Query: 244 AWCPKNEVGP-NSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV---------PKEEYPTEKQGSD 1173
AWCP+ P N KE++Q+D + L ++ + T G G G F + + Y R +GS W ++N ++IEGN ++ ++ + + IIAR +R +P+ + + VC++ YG + DG+V Y+ P G ++ L D +YDG + G+GQL D + + + V ++VGW N N +E++F FD+ R + H N + + F F + ++F D +AR++ V+L++ A ++ F W++ +E+ F ++ PK PT Q D
Sbjct: 79 AWCPEIPGEPENMKEFLQIDLRSLHFITLVGTQGRHAGGIGNEFAQTYKIKYSR-DGSRWISWRNRHGKQVIEGNRNAYDVVLQDLQPPIIARFVRFMPVIDHSMNVCMRVELYGCEWLDGLVSYNAPLGQKMILHSQPIYLNDSVYDGAMSYS----MTEGLGQLTDGMCGLDDFTFSHVYNVWPGYDYVGWTNESFPNGYVEIMFEFDRTRNFTTMKVHCNNMFSQRVKTFQKVVCYFRSESDWE---PTPVSFSPVVDDVNPSARFVTVSLNNHMASAIKCQYYFSDMWMMFSEITFQSDTAMYNTTLIPPKSGPPTSTQPGD 396
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Match: ddr2l (discoidin domain receptor family, member 2, like [Source:ZFIN;Acc:ZDB-GENE-041210-162]) HSP 1 Score: 115.546 bits (288), Expect = 1.224e-25 Identity = 77/316 (24.37%), Postives = 138/316 (43.67%), Query Frame = 1
Query: 2116 MKDYEEIIMEKLSKIDI-------EKMELQKLIGSGRYGSIKKGIYNG------------------SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
M + ++ L++ DI E++ ++ +G G++G + G +V VK + D + R FLK I + +++ N ++++ C ++ C++ ++ G L+ F+ + R + S L +A NN P + L+++A QI+ GM +L +HRDLATRNC++ +L+I I+D M N + DY I Q LP++WM+WE++L G++++ SDVW+FGV W++ T C +PY
Sbjct: 506 MYSVPAVTVDSLTRKDISVAEFPRERLIFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRSVLVAVKQLRADATSNARNDFLKEIKIMSRLNDPNIIRLLCVC-----------------VRSDPLCMVTEYMENGDLNMFLSQ--RELESTLTHA-NNIPSVSMAD--------------------LLHMAVQIASGMKYLASLNFVHRDLATRNCLLDRQLTIKISDFGMSRNLYSSDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCTEQPY 760 HSP 2 Score: 95.1301 bits (235), Expect = 2.538e-19 Identity = 91/377 (24.14%), Postives = 157/377 (41.64%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGL---DNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFP---LKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK-IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQF---------------TTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
AWCP ++ P+ +Y+QVD + L ++ + T G +GN+ F + LDY R +G W ++N ++I+GNV++ + +G + DG+ YS P+G T+ FP L D YDG+ R+ L G+GQL D +I ++ ++ +++GW+N +EM F+FD+ R + H N + + +FSS F I A+ + F D + +AR++ V L R F W++ +E+ F TT + + E P G + P + P ++LI ++T + L+ +I IL
Sbjct: 63 AWCPAGQLQPSDVQYLQVDLRQLTFVTVVATQGRYARSSGNE--FARKYRLDYSR-DGHRWISWRNRYGSEIIKGNVNTYASVV------------------------------FGCPWQDGLTAYSAPEGQ--TMMAPGFPNTLLNDSTYDGVLERRK---LLGGLGQLTDGVIGQDDFVQTRQYQLWPGYDYLGWRNDSLGPGYVEMEFQFDRQRNFTSMKVHCNNMFSRGVKVFSSVSCVFK-PHLISEWEAEPVVFSTVLDDRNPSARYVTVPLLQRSGTATRCRFFFADTWMMFSEISFHSAMNPVPTPWSRVMTTPLSETESPALTTGKTGVTTVSPKTQSPEEGGTSILI--GCLVTIILLLVVIIFLIL 398
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Match: ddr1 (discoidin domain receptor tyrosine kinase 1 [Source:NCBI gene;Acc:103035361]) HSP 1 Score: 105.145 bits (261), Expect = 1.969e-22 Identity = 79/310 (25.48%), Postives = 134/310 (43.23%), Query Frame = 1
Query: 2149 LSKIDIEKMELQKLIGSGRYG--------------------SIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLS----------ILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L ++ E++ ++ +G G++G +++KG +V VK + D + R FLK + L ++ N ++++G C S D L C++ ++ G L++++ + L++ T + T +S+ LI +A+QI+ GM FL +HRDLATRNC+VG I I D M N + DY I Q LP++WM+WE +L G++++ SDVW+FGV W++L+ CQ +PY
Sbjct: 659 LPELPRERLIFKEKLGEGQFGEVHLCEIENPQDLPNLEFPFNVRKG--RPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRLLGVCVSS-----------DPL------CMVTEYMESGDLNQYLSQR------VLLDKTGPLHNTPT-----------------ISYPALISMASQIASGMKFLASLNFVHRDLATRNCLVGGERGDGEDRMGERHIKIADFGMSRNLYAGDYYRI---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPY 905 HSP 2 Score: 102.064 bits (253), Expect = 1.987e-21 Identity = 84/304 (27.63%), Postives = 145/304 (47.70%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNR-KIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIG-GEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTN 1131
AWCP V P+ E++QV+ L LS + T G +G+ F + L Y R +G W +K+ ++I GN ++ ++ + IIAR +R P+++ +VCL+ YG +NDG+ Y+ P G + + L D IYDG IE L G+GQL D ++ + V ++VGW + +++ F F+K RI + H N + + +FS EF + + + A + DLK ++R + + L PA+ +R F +W++++E+ F +
Sbjct: 76 AWCPAGAVFPSGSEFLQVNLHKLHFLSLVGTQGRHADGHGREFARSYRLRYSR-DGRQWITWKDRWGQEVISGNENTYDVVLKDLGPPIIARMVRFYPLADRVMSVCLRVELYGCVWNDGLKAYAAPMGHVMHLSGSPIYLNDSIYDGSIEA----GTLFGGLGQLCDGVLGGDDFMESKELRVWPGYDYVGWSREALGQPTVDIEFHFEKTRIFHVMQVHSNNRHTQGVRVFSEVVCEFKASLLDHWTEPALKLRVPLE-DLKDPSSRSVDLPLGGRPAQILRCHFAFADRWLLISEISFNSE 373
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Match: ddr1 (discoidin domain receptor tyrosine kinase 1 [Source:NCBI gene;Acc:103035361]) HSP 1 Score: 105.145 bits (261), Expect = 2.237e-22 Identity = 79/310 (25.48%), Postives = 134/310 (43.23%), Query Frame = 1
Query: 2149 LSKIDIEKMELQKLIGSGRYG--------------------SIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLS----------ILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L ++ E++ ++ +G G++G +++KG +V VK + D + R FLK + L ++ N ++++G C S D L C++ ++ G L++++ + L++ T + T +S+ LI +A+QI+ GM FL +HRDLATRNC+VG I I D M N + DY I Q LP++WM+WE +L G++++ SDVW+FGV W++L+ CQ +PY
Sbjct: 678 LPELPRERLIFKEKLGEGQFGEVHLCEIENPQDLPNLEFPFNVRKG--RPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRLLGVCVSS-----------DPL------CMVTEYMESGDLNQYLSQR------VLLDKTGPLHNTPT-----------------ISYPALISMASQIASGMKFLASLNFVHRDLATRNCLVGGERGDGEDRMGERHIKIADFGMSRNLYAGDYYRI---------------------QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPY 924 HSP 2 Score: 102.449 bits (254), Expect = 1.604e-21 Identity = 84/304 (27.63%), Postives = 145/304 (47.70%), Query Frame = 1
Query: 244 AWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNR-KIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIG-GEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTN 1131
AWCP V P+ E++QV+ L LS + T G +G+ F + L Y R +G W +K+ ++I GN ++ ++ + IIAR +R P+++ +VCL+ YG +NDG+ Y+ P G + + L D IYDG IE L G+GQL D ++ + V ++VGW + +++ F F+K RI + H N + + +FS EF + + + A + DLK ++R + + L PA+ +R F +W++++E+ F +
Sbjct: 95 AWCPAGAVFPSGSEFLQVNLHKLHFLSLVGTQGRHADGHGREFARSYRLRYSR-DGRQWITWKDRWGQEVISGNENTYDVVLKDLGPPIIARMVRFYPLADRVMSVCLRVELYGCVWNDGLKAYAAPMGHVMHLSGSPIYLNDSIYDGSIE----AGTLFGGLGQLCDGVLGGDDFMESKELRVWPGYDYVGWSREALGQPTVDIEFHFEKTRIFHVMQVHSNNRHTQGVRVFSEVVCEFKASLLDHWTEPALKLRVPLE-DLKDPSSRSVDLPLGGRPAQILRCHFAFADRWLLISEISFNSE 392
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009339.1 (pep scaffold:Pmarinus_7.0:GL479558:1022:6538:1 gene:ENSPMAG00000008449.1 transcript:ENSPMAT00000009339.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 108.227 bits (269), Expect = 1.019e-26 Identity = 49/124 (39.52%), Postives = 71/124 (57.26%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L+Y+A+QI GM++L +HRDLATRNC+VG +I I D M N + DY I Q LP++WM+WE++L G+++ SDVW+FGV W++LT C+ +PY
Sbjct: 85 LVYMASQIVSGMAYLSSLNFVHRDLATRNCLVGEHHTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMAWESILLGKFTPASDVWAFGVTLWEMLTLCREQPY 187
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 98.9821 bits (245), Expect = 3.443e-23 Identity = 60/238 (25.21%), Postives = 110/238 (46.22%), Query Frame = 1
Query: 2278 PSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF 2991
P ++ +F + + + + + N VK++G C PF C++ + G L++++RR S A + P S S ++ +++A Q++ GM++L +HRDLATRNC+VG RL + I+D + + + DY N+ + ++P++WM E++ RY+S+SDVW+FGV+ W++ + +PYF
Sbjct: 2 PDMQANFHREAALMAEFTHPNIVKLLGVCAVGK-------PF----------CLLFEFMPHGDLNEYLRRCSSEAGLAASSPPARAPTSSGSEPVSLCCADK------------LFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKANE---------------------NDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSH-GLQPYF 188
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 91.6633 bits (226), Expect = 2.989e-20 Identity = 72/296 (24.32%), Postives = 129/296 (43.58%), Query Frame = 1
Query: 2155 KIDIEKMELQKLIGSGRYGSIKKGIYNGSV-------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINAT--NNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTN 3015
+++ +K+++ + +G G +G + +G+ G V V +K +N R FL S + + + V+++G + Q IL +IM+ +G L ++R RP + KP S ++ +A +I+DGM++L + +HRDLA RNC+V ++ I D M + ++ DY G + LP++WMS E++ G +++ SDVWSFGV+ W++ T + +PY Q L+N
Sbjct: 7 EVERDKVKMMRELGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQA----------QPIL-------VIMELMTRGDLKSYLR-SLRPDAEDFTETIVLEKKPTRPPSSLPE-----------------MLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG---------GKGL------------LPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAE-QPY----QGLSN 241
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 92.8189 bits (229), Expect = 9.764e-20 Identity = 71/294 (24.15%), Postives = 128/294 (43.54%), Query Frame = 1
Query: 2155 KIDIEKMELQKLIGSGRYGSIKKGIYNGSV-------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTN 3015
+++ +K+++ + +G G +G + +G+ G V V +K +N R FL S + + + V+++G + Q IL +IM+ +G L ++R +L KP S ++ +A +I+DGM++L + +HRDLA RNC+V ++ I D M + ++ DY G + LP++WMS E++ G +++ SDVWSFGV+ W++ T + +PY Q L+N
Sbjct: 55 EVERDKVKMMRELGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQA----------QPIL-------VIMELMTRGDLKSYLR--------SLRPDAEKKPTRPPSSLPE-----------------MLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG---------GKGL------------LPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAE-QPY----QGLSN 280
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 85.8853 bits (211), Expect = 3.621e-17 Identity = 70/288 (24.31%), Postives = 121/288 (42.01%), Query Frame = 1
Query: 2164 IEKMELQK--LIGSGRYGSIKKGIYNGSV------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVN-INFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVP 3000
+++ EL+K ++GSG +G++ KGI+ V +K + P L + +S + V+++G C L PS+ ++ Q G L ++ R H + S L L+ A QI+ GM +LE + L+HRDLA RN +V + ITD L+ L +D+N I ++ +P++W++ E++ ++ +SDVWS+GV W+L+TF +PY +P
Sbjct: 569 LKETELRKGKMLGSGAFGTVHKGIWTPEGEDVKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGIC-----------------LTPSVQ-LVTQLMPLGCLLEYTREHKEHIGSQL----------------------------------LLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFG----------------LARL------LDINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTF-GGKPYEGIP 781
BLAST of Discoidin domain-containing receptor vs. Ensembl Yeast
Match: YPK3 (AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation [Source:SGD;Acc:S000000232]) HSP 1 Score: 48.9062 bits (115), Expect = 4.181e-6 Identity = 30/114 (26.32%), Postives = 57/114 (50.00%), Query Frame = 1
Query: 2623 YIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLL 2964
+ AA+IS + FL +G+++RDL NC++ R +++TD ++K ++ S + + N+N + P ++ + E +L YS D +S G L +D+L
Sbjct: 256 FYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTD------------FGLSKKSANDSAVDEEDPENVNALYSIIGTP-EYCAPEILLGKAYSQNCDWYSLGCLLYDML 356
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Match: EDO44269 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW90]) HSP 1 Score: 100.523 bits (249), Expect = 1.838e-23 Identity = 60/236 (25.42%), Postives = 105/236 (44.49%), Query Frame = 1
Query: 2281 SVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+++ F K + + + +N V+++G C K C+I+++ G L++F+++ L + + P T + L+Y+A Q++ GM ++ +HRDLATRNC+VG ++ I D M + + K Y I Q V LP++WM+ E +L+G+++S SDVW+FGV W++LT PY
Sbjct: 9 NIKQDFFKEVKIMAGVRHENVVRLLGVC------------------KDDPMCMIVEYMENGDLNQFLKQRE------LASGNSADPNKVT-------------------YQALLYMALQLAAGMKYIASHQFVHRDLATRNCLVGHSFTVKIADFGMSRHLYSKHYYRI---------------------QGRVILPIRWMAPECILQGKFTSASDVWAFGVTLWEILTLAAEYPY 180
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Match: EDO48215 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKA9]) HSP 1 Score: 103.219 bits (256), Expect = 2.022e-22 Identity = 84/338 (24.85%), Postives = 144/338 (42.60%), Query Frame = 1
Query: 2092 FDGNESFTMKDYEEIIMEKLSKID--IEKMELQKLIGSGRYGSI--------KKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYI-TINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKC 3072
+ +ES +I++ SKI E + L K +G G YG + +G + V+V ++ VR F + K+ N + IVG C+ S +C++ ++ G LH+++ R NA + P ++ LI IA Q++ GM++L ++H DLATRNC+VGP ++ ITD A+ + DY +++ +P LP++WM+ EA+L R++ ++D+WSFGVL W+L ++ +P+F +N D +C+ L C
Sbjct: 373 YQADESAAPMPLMPVIVKTTSKIREIKESLRLLKELGEGDYGKVYFGEITTKSEGRLMATSVLVVSLRESHEVDVRDEFFEKAEAWSKLQHPNIITIVGMCNKSVP-----------------TCVLYEYLEYGTLHEYLVR----------NAPIDDPEAEEEIADPLWCDG------------LISIAYQVAAGMNYLSSNNIVHGDLATRNCMVGPGRTVKITDVALTRLGYSHDYYRQLHR-------------------RP---LPVRWMAPEAILSYRFTPETDIWSFGVLLWELFSY-GAQPHF----GFSNEDVMFRLRECILLPCPVDC 644
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Match: EDO45490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSX1]) HSP 1 Score: 90.8929 bits (224), Expect = 1.773e-20 Identity = 65/250 (26.00%), Postives = 111/250 (44.40%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF 2991
+V VK + + C ++ SFL+ ++ + + N V+++ EE P+ +I + QG L++++R+ P S + S T + L+ I+ Q+S GM L+ +HRDLATRNC+VG L + I D M + + DY + + +P++WM EA+L GR++ +SDV+SFGVL W++ F +PY+
Sbjct: 3 IVAVKTLKQGCSNEMKTSFLQEVTLMAVLHHPNIVELLAVST-------EEEPYG----------MIFEFMSQGDLNQYMRKRG-PYSLE----------EEKSLTQED----------------LLSISLQVSSGMEHLQSMRFVHRDLATRNCLVGDGLVVKIADFGMSRDVYASDYYKV---------------------EGQAVMPIRWMPPEALLYGRFTVESDVYSFGVLLWEVYAFA-LQPYY 186
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 90.5077 bits (223), Expect = 1.245e-19 Identity = 69/281 (24.56%), Postives = 124/281 (44.13%), Query Frame = 1
Query: 2167 EKMELQKLIGSGRYGSIKKGIYNGSV-------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
EK++L + +G+G +G + +G V V VK ++ + RI FL+ S + + V+++G +G+ + ++M+ G L F+R H RP + +++P + ++ +A +I+DGM++L +HRDLA RNC+V L++ I D M + ++ DY G + LP++WM+ E++ G ++S SDVWSFGV+ W++ T +PY
Sbjct: 16 EKIKLIRELGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLG-----VVSDGQP------------TLVVMELMDNGDLKNFLRSH-RPE----VTMESDEPPP--------------------TLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKG---------GKGL------------LPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLAS-QPY 232
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Match: EDO39761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S933]) HSP 1 Score: 87.4261 bits (215), Expect = 3.757e-19 Identity = 42/125 (33.60%), Postives = 69/125 (55.20%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYF 2991
L+ IA Q++ GM ++ +HRDLATRNC+VG + + I D M + + DY +++ LP++W++ EA L G+++ KSDV+S+GVL W++ TF +PY+
Sbjct: 72 LVGIAEQVAAGMEYVASLRFVHRDLATRNCLVGTDMVVKIADFGMSRDVYGSDYYKMSR---------------------ETMLPIRWLAPEAFLYGKFTVKSDVYSYGVLLWEIFTF-GLQPYY 174
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Match: ddr2a (discoidin domain receptor tyrosine kinase 2 [Source:NCBI gene;Acc:101161722]) HSP 1 Score: 127.102 bits (318), Expect = 3.557e-29 Identity = 75/249 (30.12%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C YS P C+I ++ G L++F+ RH AL++ T S+ L Y+A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W++L FC+ +PY
Sbjct: 609 LVAVKMLRSDANGNARNDFLKEIKIMSRLKDPNIIRLLAVCIYSN-------PL----------CMITEYMENGDLNQFLSRHEPEGQLALLSNTATVSFSN-----------------------LCYMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPY 796 HSP 2 Score: 104.375 bits (259), Expect = 3.436e-22 Identity = 91/339 (26.84%), Postives = 157/339 (46.31%), Query Frame = 1
Query: 244 AWCPKNEVGP-NSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFT------------------TNVPKEEYPTEK-QGSDTR 1179
AWCP+ V P N KE+IQ+D L ++ + T G G G F + + Y R +GS W ++N ++IEGN ++ + + IIAR +R +P+++ + VC++ YG + DG+V Y+ P G+ + D +YDG I H ++ G+GQL D ++ + + + ++VGW N + +E++F FD+ R + H N ++I IF F + ++F D +AR++ V L++ A ++ F+ W++ +E+ F TN P E+ PT K S+TR
Sbjct: 71 AWCPETTVEPDNLKEFIQIDLNLLHFITLVGTQGRHAGGMGNEFAQMYMIKYSR-DGSRWISWRNRQGKQVIEGNRNTYDTVLRDLDPPIIARFVRFMPVTDHSMNVCMRVELYGCKWLDGLVSYNAPAGEQMKLPAFPVFFNDSVYDGAITH-----MMTEGLGQLSDGVMGLDDFTQSHVYQAWPGYDYVGWNNESFPSGFVEIMFEFDRPRNFTTMKVHCNNMFSQHIKIFRQVVCYFRSDSDWESTV---LSFSPVVDENDPSARFITVELTNRMANAIKCQFYFKDAWMLFSEITFQSDRAMYNTTLVPPTIGPPTNTPPEDDPTHKIDDSNTR 400
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Match: ddr2a (discoidin domain receptor tyrosine kinase 2 [Source:NCBI gene;Acc:101161722]) HSP 1 Score: 127.102 bits (318), Expect = 3.557e-29 Identity = 75/249 (30.12%), Postives = 114/249 (45.78%), Query Frame = 1
Query: 2242 VVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+V VK + D + R FLK I + ++ N ++++ C YS P C+I ++ G L++F+ RH AL++ T S+ L Y+A QI+ GM +L +HRDLATRNC+VG +I I D M N + DY I Q LP++WMSWE++L G++++ SDVW+FGV W++L FC+ +PY
Sbjct: 609 LVAVKMLRSDANGNARNDFLKEIKIMSRLKDPNIIRLLAVCIYSN-------PL----------CMITEYMENGDLNQFLSRHEPEGQLALLSNTATVSFSN-----------------------LCYMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPY 796 HSP 2 Score: 104.375 bits (259), Expect = 3.436e-22 Identity = 91/339 (26.84%), Postives = 157/339 (46.31%), Query Frame = 1
Query: 244 AWCPKNEVGP-NSKEYIQVDFKDLKALSYLVTNGLDNGNDG-FFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDG-IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFD-KNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFT------------------TNVPKEEYPTEK-QGSDTR 1179
AWCP+ V P N KE+IQ+D L ++ + T G G G F + + Y R +GS W ++N ++IEGN ++ + + IIAR +R +P+++ + VC++ YG + DG+V Y+ P G+ + D +YDG I H ++ G+GQL D ++ + + + ++VGW N + +E++F FD+ R + H N ++I IF F + ++F D +AR++ V L++ A ++ F+ W++ +E+ F TN P E+ PT K S+TR
Sbjct: 71 AWCPETTVEPDNLKEFIQIDLNLLHFITLVGTQGRHAGGMGNEFAQMYMIKYSR-DGSRWISWRNRQGKQVIEGNRNTYDTVLRDLDPPIIARFVRFMPVTDHSMNVCMRVELYGCKWLDGLVSYNAPAGEQMKLPAFPVFFNDSVYDGAITH-----MMTEGLGQLSDGVMGLDDFTQSHVYQAWPGYDYVGWNNESFPSGFVEIMFEFDRPRNFTTMKVHCNNMFSQHIKIFRQVVCYFRSDSDWESTV---LSFSPVVDENDPSARFITVELTNRMANAIKCQFYFKDAWMLFSEITFQSDRAMYNTTLVPPTIGPPTNTPPEDDPTHKIDDSNTR 400
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Match: ENSORLT00000021512.2 (discoidin domain-containing receptor 2 [Source:NCBI gene;Acc:101165486]) HSP 1 Score: 120.939 bits (302), Expect = 2.546e-27 Identity = 104/373 (27.88%), Postives = 184/373 (49.33%), Query Frame = 1
Query: 232 DSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNG-LDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFP---LKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQNFDKNRK--IEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNV-PKEEYPTEKQG-------SDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICIL 1296
D AWCP+ ++ + +Y+QVD L L+ + T G G F + L+Y R +G W +KN + +IEGN ++ + + +IIAR +R+IP++ ++ TVC++ YG ++DG++ YS P+G + + +P L D IYDG R+ L G+GQL D ++ + + +V +++GW+N + + +EM F FD+ R + H N + + IFSS F I + +TF+ D + +AR++ V L+ AK +R F W++ +E+ F + + T QG T ++ P++ PT + N ++ C ++T + L+ +I IL
Sbjct: 60 DGDGAWCPEGQLQHSDTQYLQVDLSVLTFLTLVGTQGRYARGLGKEFARAYRLNYSR-DGLTWKAWKNRQGNTVIEGNKNTYAIVYKELHPSIIARYVRLIPVTELSSTVCMRVELYGCPWHDGLISYSAPEGQL--MMPPGYPPASLNDSIYDGTHERRP---LFGGLGQLTDGVVGMDDFLLTHEKQVWSGYDYLGWRNDSQGTQGHVEMEFVFDRQRNFTSMKVHSNNLFTRGVKIFSSVSCWFK-PRLIANWEQEAVTFRTVLDDRNPSARYVTVPLNQRTAKALRCRFYFADVWMMFSEISFQSGENLHPDLKTSTQGIIPTTPLITTAAQPAPSANDPTEETNTPILIGC-LVTIILLLVVIIFLIL 424 HSP 2 Score: 117.857 bits (294), Expect = 2.191e-26 Identity = 88/325 (27.08%), Postives = 140/325 (43.08%), Query Frame = 1
Query: 2089 KFDGNESFTMKDYEEIIMEKLSKIDIEKMEL--QKLI-----GSGRYGSIKKGIYNG------------------SVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
+ G M + ++ L++ DI E Q+LI G G++G + G +V VK + D R FLK I + ++ N ++++ C S D L C++ ++ G L+ F+ + R + S L +A N+ P S + C L+++A QIS GM +L +HRDLATRNC+V RL+I I D M N + DY I Q LP++WM+WE++L G++++ SDVW+FGV W++ T C+ +PY
Sbjct: 506 RLQGVTGSNMYAVPALTVDSLTRKDISAAEFPRQQLIFREKLGEGQFGEVHLCEAEGLPEFLGEGSPLPDRDSRPVLVAVKQLRADATLQARNDFLKEIKIMSRLDDPNIIRLLCVCVSS-----------DPL------CMVTEYMENGDLNMFLSQ--REIESTLTHA-NSIP-SVSLCD-------------------LLHMAVQISSGMKYLASLNFVHRDLATRNCLVDRRLTIKIADFGMSRNLYSSDYYRI---------------------QGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPY 769
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Match: ddr2b (discoidin domain-containing receptor 2 [Source:NCBI gene;Acc:101156357]) HSP 1 Score: 113.235 bits (282), Expect = 6.618e-25 Identity = 99/361 (27.42%), Postives = 164/361 (45.43%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQN--FDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINN-----LLICFCVIITFVGLMCIISI 1287
AWCP P+ KEY+QVD + L ++ + T G +G F + + Y R +GS W +++ ++IEGN ++ ++ + + IIAR +R +P+++ + VC++ YG + DG+V YS+P G ++ D +YDG L +G+GQL D + V ++VGW N F K +EMIF FD VR + H N + + +F F E ITF+ D + AR++ V L D AK ++ F W++ +EV F + Y T G K+ PT K+++ L+ C +I + + +I +
Sbjct: 74 AWCPDIMSEPHGLKEYLQVDLRSLHFITLVGTQGRHADGMGNEFAQRYRIKYSR-DGSNWVSWQDRKGQQVIEGNRNAYDVVLKDLEPPIIARYVRFMPVTDHSMIVCMRVELYGCEWLDGLVSYSIPDGHQMIYRDLEVSFNDSVYDGAS-------LTKGLGQLTDGTWGLDDFLHSQIYGVWPGYDYVGWSNRTFPKG-YVEMIFDFDHVRNFTSMKVHTSNMFSRGVRVFRQVTCFFWSDSEWE---PGPITFRPTPDRVSQRARFVTVTLGDRTAKTIKCRFHFSDVWMLFSEVAFQSG--SAVYNT-SMGPGKHPKNPLPVDDPTHKVDDSNTRILIGCLVAVIAILSAIIVIML 419 HSP 2 Score: 108.997 bits (271), Expect = 1.246e-23 Identity = 79/298 (26.51%), Postives = 127/298 (42.62%), Query Frame = 1
Query: 2149 LSKIDIEKMELQKLIGSGRYGSI----KKGIYN--------GSV------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
L + EK+ ++ +G G++G + +G+ + G + V VK + D + R FLK I + ++ N V+++ C TD P +I ++ G L++F+ R ++ T LI +A QI+ GM +L +HRDLATRNC+VG +I I D M N ++ DY I Q LP++WMSWE++L G+++ SDVW+FGV W++LT C+ +PY
Sbjct: 545 LREFPREKLSFKEKLGEGQFGEVHLCEAEGMQDFLDEDLSVGEISESLLLVAVKTLREDANKNARNDFLKEIRIMSRLRDPNIVRLLAVC--VDTD-----PL----------WMITEYMENGDLNQFLSRSKIFFLFGALSYTK-----------------------------LINMAVQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIRIADFGMSRNLYKGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPY 775
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Match: ddr2b (discoidin domain-containing receptor 2 [Source:NCBI gene;Acc:101156357]) HSP 1 Score: 112.464 bits (280), Expect = 9.669e-25 Identity = 99/361 (27.42%), Postives = 164/361 (45.43%), Query Frame = 1
Query: 244 AWCPKNEVGPNS-KEYIQVDFKDLKALSYLVTNGLD-NGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV----NFVGWQN--FDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINN-----LLICFCVIITFVGLMCIISI 1287
AWCP P+ KEY+QVD + L ++ + T G +G F + + Y R +GS W +++ ++IEGN ++ ++ + + IIAR +R +P+++ + VC++ YG + DG+V YS+P G ++ D +YDG L +G+GQL D + V ++VGW N F K +EMIF FD VR + H N + + +F F E ITF+ D + AR++ V L D AK ++ F W++ +EV F + Y T G K+ PT K+++ L+ C +I + + +I +
Sbjct: 66 AWCPDIMSEPHGLKEYLQVDLRSLHFITLVGTQGRHADGMGNEFAQRYRIKYSR-DGSNWVSWQDRKGQQVIEGNRNAYDVVLKDLEPPIIARYVRFMPVTDHSMIVCMRVELYGCEWLDGLVSYSIPDGHQMIYRDLEVSFNDSVYDGASAEG----LTKGLGQLTDGTWGLDDFLHSQIYGVWPGYDYVGWSNRTFPKG-YVEMIFDFDHVRNFTSMKVHTSNMFSRGVRVFRQVTCFFWSDSEWE---PGPITFRPTPDRVSQRARFVTVTLGDRTAKTIKCRFHFSDVWMLFSEVAFQSG--SAVYNT-SMGPGKHPKNPLPVDDPTHKVDDSNTRILIGCLVAVIAILSAIIVIML 414 HSP 2 Score: 110.153 bits (274), Expect = 5.212e-24 Identity = 80/295 (27.12%), Postives = 129/295 (43.73%), Query Frame = 1
Query: 2167 EKMELQKLIGSGRYGSI----KKGIYN--------GSV------VVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFI---RRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPY 2988
EK+ ++ +G G++G + +G+ + G + V VK + D + R FLK I + ++ N V+++ C TD P +I ++ G L++F+ R P + + G D+ + LI +A QI+ GM +L +HRDLATRNC+VG +I I D M N ++ DY I Q LP++WMSWE++L G+++ SDVW+FGV W++LT C+ +PY
Sbjct: 552 EKLSFKEKLGEGQFGEVHLCEAEGMQDFLDEDLSVGEISESLLLVAVKTLREDANKNARNDFLKEIRIMSRLRDPNIVRLLAVC--VDTD-----PL----------WMITEYMENGDLNQFLCNLRLKEAPDE----DKPEQEEGEDSISYTK-----------------LINMAVQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIRIADFGMSRNLYKGDYYRI---------------------QGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPY 787
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Match: SMESG000016549.1 (SMESG000016549.1) HSP 1 Score: 2165.58 bits (5610), Expect = 0.000e+0 Identity = 1129/1135 (99.47%), Postives = 1133/1135 (99.82%), Query Frame = 1
Query: 25 MGAELNIQFVIFVLLTGFIFSQFLPSFRGKDTNYNLINDLSDDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEVNFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDTRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICILXXXXXXXXXIKGKPLHSIRYGNMPINNVIPIPVVSSSNGGIYKPIPNGVYDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDNYNATLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSLDKKTLPLHLVPLSPTMYEQYKLXXXXXXXXXXXXXXFNLMSPVLQSYQQDSRQTFVDNFPVNSLAPSMINNYVQPFIYQPANLTIDSSIIRWPNELYELLEKHSRFDTCLQSPVGGSTVLREKFDGNESFTMKDYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTXXXXXXXXXXXXXXXXXXCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 3429
MGAELNIQFVIFVLLTGFIFSQFLPSFRGKDTNYNLINDLSDDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGS WHRYKNE+DHKLIEGNVDSRNMKITKFKSNIIARRIRIIPISNITKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDNIINENSIASINNGEVNFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSD+RSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICILRFRRQRKRRIKGKPLHSIRYGNMPINNVIPIPVVSSSNGGIYKPIPNG+YDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDNYNATLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSL+KKTLPLHLVPLSPTMYEQYKLNPNNHHG PNPPHQFNLMSPVLQSYQQDSRQTFVDNFPVNSLAPSMINNYVQPFIYQPANLTIDSSIIRWPNELYELLEKHSRFDTCLQSPVGGSTVLREKFDGNESFTMKDYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTSVEDEPEESSSKPLLSHSCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS
Sbjct: 1 MGAELNIQFVIFVLLTGFIFSQFLPSFRGKDTNYNLINDLSDDAFSCSSFRDNFFPYLAREKNSKNRMIDSPQAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSEWHRYKNESDHKLIEGNVDSRNMKITKFKSNIIARRIRIIPISNITKTVCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQIKFPLKDRIYDGIEHRKNDNVLRRGIGQLMDNIINENSIASINNGEVNFVGWQNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEVQFTTNVPKEEYPTEKQGSDSRSKSKPNSMFPTSKINNLLICFCVIITFVGLMCIISICILRFRRQRKRRIKGKPLHSIRYGNMPINNVIPIPVVSSSNGGIYKPIPNGIYDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDNYNATLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSLEKKTLPLHLVPLSPTMYEQYKLNPNNHHGLPNPPHQFNLMSPVLQSYQQDSRQTFVDNFPVNSLAPSMINNYVQPFIYQPANLTIDSSIIRWPNELYELLEKHSRFDTCLQSPVGGSTVLREKFDGNESFTMKDYEEIIMEKLSKIDIEKMELQKLIGSGRYGSIKKGIYNGSVVVVKAINRDCVPSVRISFLKMISDLMKISSKNFVKIVGYCDYSTTDEGEEFPFQDILLKPSISCIIMQHTHQGYLHKFIRRHSRPVSSALINATNNKPGSDTSCTSVEDEPEESSSKPLLSHSCLIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGMDIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 1135
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Match: SMESG000067438.1 (SMESG000067438.1) HSP 1 Score: 207.994 bits (528), Expect = 2.347e-54 Identity = 186/598 (31.10%), Postives = 294/598 (49.16%), Query Frame = 1
Query: 127 NLINDLSDDAFSCSSFRDN---FFPYLAREKNSKNRMIDSP----QAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKT-VCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ--IKFPLKDRIYDG---IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV---NFVGW-QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEV-----QFTTNVPKEE------YPTEKQGSDTR---SKSKPNSMFPTSKINNLL----ICFCVIITFVGLMCIISICILXXXXXXXXXI-------------KGK---PLHSIRYGNMP-INNVIPIPVV-----SSSNGGIYKPIPNGV-----YDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDN--YNA--TLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSL 1722
NL+ +L +++F SS F P+ AR K +D P AWCPK + + +E+I++D DLK + L T G +GN + FYLDYQR +G W RY+N+ +L+ GN D+RN+ +T F+S IIARRIRI PIS + C++ YG +F+DGVVEYS+ QG +T K+ L+D YDG I+ +L G+GQLMDN+I I+ +N ++ +FVGW + F + K+E++ +FD++R +K + F+ +N + ++I +FSSA FS GG Y + + FK D ++ RW+++ L + A+F+++ L F + WI+L+E+ ++ +PKE YP + + + S + P + NN + + +GL+ IS C L F + KGK P++ R P I + + +P+ SS G Y P V Y M G + TL+ + T+Y + N G+ P + YN + + +GQ + R S DGS G SSN +Y++ SL
Sbjct: 47 NLVANLKNESFIASSVWKEIVEFEPHQARMKQ-----MDDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRVSGK-WIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPISKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYHFVGWNRKFLDSNKVEIVMKFDQMRSVKQIRFYAMNMIPEDIGVFSSAIIHFSRGGVYYDRISPAYQFKTVIDTRVYYPRWINITLQNVLARFLKIDLFFEVDWIILSEIVIISEKYNEIIPKESESIQTNYPITHNITSVKYIPTDSTATVLIPQNGKNNHIDTNRSSSFTASSSLGLIATISSCFLGFVFLIALIVFGVFTLRRHKKRTKGKLRNPIYQTRINGGPFIGDSVVVPLTGGTQSSSGTGSFYYKYPGNVELGLTYPVM-GKEYMTLSSKSGTDY------------DMAGGNSLDGLIPTGTRDIKYNGMNSYAPPMGQNDSPYPTNIYSRNSADGSTGGSSNTDYASTSL 625 HSP 2 Score: 139.043 bits (349), Expect = 7.645e-33 Identity = 94/275 (34.18%), Postives = 137/275 (49.82%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGM----DIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 3429
L++I QI+ GMS+LE +IHRDLA RNC++G L I ITD AM KF++ YI + + +G+ D D N + PLQWM++E++L+ YS K+D+WSFGV W++L CQ PY + I A +N L G +++ P NE+L P SQ N + +AN + + H+D L +R+ DLI CW+ P RP FK IS L+QKI NF ++ + + + S
Sbjct: 943 LLFIITQIARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYI-------ECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNA---------YN---LSIGNSSAVFP-NENL--------------YPHQSQ-SNFRPSQHMAN-PSSSILHED------LGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITNFEFANDHSNLFSTINNS 1175
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Match: SMESG000067438.1 (SMESG000067438.1) HSP 1 Score: 207.994 bits (528), Expect = 2.401e-54 Identity = 186/598 (31.10%), Postives = 294/598 (49.16%), Query Frame = 1
Query: 127 NLINDLSDDAFSCSSFRDN---FFPYLAREKNSKNRMIDSP----QAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKT-VCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ--IKFPLKDRIYDG---IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV---NFVGW-QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEV-----QFTTNVPKEE------YPTEKQGSDTR---SKSKPNSMFPTSKINNLL----ICFCVIITFVGLMCIISICILXXXXXXXXXI-------------KGK---PLHSIRYGNMP-INNVIPIPVV-----SSSNGGIYKPIPNGV-----YDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDN--YNA--TLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSL 1722
NL+ +L +++F SS F P+ AR K +D P AWCPK + + +E+I++D DLK + L T G +GN + FYLDYQR +G W RY+N+ +L+ GN D+RN+ +T F+S IIARRIRI PIS + C++ YG +F+DGVVEYS+ QG +T K+ L+D YDG I+ +L G+GQLMDN+I I+ +N ++ +FVGW + F + K+E++ +FD++R +K + F+ +N + ++I +FSSA FS GG Y + + FK D ++ RW+++ L + A+F+++ L F + WI+L+E+ ++ +PKE YP + + + S + P + NN + + +GL+ IS C L F + KGK P++ R P I + + +P+ SS G Y P V Y M G + TL+ + T+Y + N G+ P + YN + + +GQ + R S DGS G SSN +Y++ SL
Sbjct: 49 NLVANLKNESFIASSVWKEIVEFEPHQARMKQ-----MDDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRVSGK-WIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPISKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYHFVGWNRKFLDSNKVEIVMKFDQMRSVKQIRFYAMNMIPEDIGVFSSAIIHFSRGGVYYDRISPAYQFKTVIDTRVYYPRWINITLQNVLARFLKIDLFFEVDWIILSEIVIISEKYNEIIPKESESIQTNYPITHNITSVKYIPTDSTATVLIPQNGKNNHIDTNRSSSFTASSSLGLIATISSCFLGFVFLIALIVFGVFTLRRHKKRTKGKLRNPIYQTRINGGPFIGDSVVVPLTGGTQSSSGTGSFYYKYPGNVELGLTYPVM-GKEYMTLSSKSGTDY------------DMAGGNSLDGLIPTGTRDIKYNGMNSYAPPMGQNDSPYPTNIYSRNSADGSTGGSSNTDYASTSL 627 HSP 2 Score: 139.043 bits (349), Expect = 7.725e-33 Identity = 94/275 (34.18%), Postives = 137/275 (49.82%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGM----DIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 3429
L++I QI+ GMS+LE +IHRDLA RNC++G L I ITD AM KF++ YI + + +G+ D D N + PLQWM++E++L+ YS K+D+WSFGV W++L CQ PY + I A +N L G +++ P NE+L P SQ N + +AN + + H+D L +R+ DLI CW+ P RP FK IS L+QKI NF ++ + + + S
Sbjct: 945 LLFIITQIARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYI-------ECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNA---------YN---LSIGNSSAVFP-NENL--------------YPHQSQ-SNFRPSQHMAN-PSSSILHED------LGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITNFEFANDHSNLFSTINNS 1177
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Match: SMESG000067438.1 (SMESG000067438.1) HSP 1 Score: 207.994 bits (528), Expect = 2.747e-54 Identity = 186/598 (31.10%), Postives = 294/598 (49.16%), Query Frame = 1
Query: 127 NLINDLSDDAFSCSSFRDN---FFPYLAREKNSKNRMIDSP----QAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKT-VCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ--IKFPLKDRIYDG---IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV---NFVGW-QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEV-----QFTTNVPKEE------YPTEKQGSDTR---SKSKPNSMFPTSKINNLL----ICFCVIITFVGLMCIISICILXXXXXXXXXI-------------KGK---PLHSIRYGNMP-INNVIPIPVV-----SSSNGGIYKPIPNGV-----YDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDN--YNA--TLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSL 1722
NL+ +L +++F SS F P+ AR K +D P AWCPK + + +E+I++D DLK + L T G +GN + FYLDYQR +G W RY+N+ +L+ GN D+RN+ +T F+S IIARRIRI PIS + C++ YG +F+DGVVEYS+ QG +T K+ L+D YDG I+ +L G+GQLMDN+I I+ +N ++ +FVGW + F + K+E++ +FD++R +K + F+ +N + ++I +FSSA FS GG Y + + FK D ++ RW+++ L + A+F+++ L F + WI+L+E+ ++ +PKE YP + + + S + P + NN + + +GL+ IS C L F + KGK P++ R P I + + +P+ SS G Y P V Y M G + TL+ + T+Y + N G+ P + YN + + +GQ + R S DGS G SSN +Y++ SL
Sbjct: 64 NLVANLKNESFIASSVWKEIVEFEPHQARMKQ-----MDDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRVSGK-WIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPISKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYHFVGWNRKFLDSNKVEIVMKFDQMRSVKQIRFYAMNMIPEDIGVFSSAIIHFSRGGVYYDRISPAYQFKTVIDTRVYYPRWINITLQNVLARFLKIDLFFEVDWIILSEIVIISEKYNEIIPKESESIQTNYPITHNITSVKYIPTDSTATVLIPQNGKNNHIDTNRSSSFTASSSLGLIATISSCFLGFVFLIALIVFGVFTLRRHKKRTKGKLRNPIYQTRINGGPFIGDSVVVPLTGGTQSSSGTGSFYYKYPGNVELGLTYPVM-GKEYMTLSSKSGTDY------------DMAGGNSLDGLIPTGTRDIKYNGMNSYAPPMGQNDSPYPTNIYSRNSADGSTGGSSNTDYASTSL 642 HSP 2 Score: 138.658 bits (348), Expect = 8.600e-33 Identity = 94/275 (34.18%), Postives = 137/275 (49.82%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGM----DIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 3429
L++I QI+ GMS+LE +IHRDLA RNC++G L I ITD AM KF++ YI + + +G+ D D N + PLQWM++E++L+ YS K+D+WSFGV W++L CQ PY + I A +N L G +++ P NE+L P SQ N + +AN + + H+D L +R+ DLI CW+ P RP FK IS L+QKI NF ++ + + + S
Sbjct: 960 LLFIITQIARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYI-------ECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNA---------YN---LSIGNSSAVFP-NENL--------------YPHQSQ-SNFRPSQHMAN-PSSSILHED------LGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITNFEFANDHSNLFSTINNS 1192
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Match: SMESG000067438.1 (SMESG000067438.1) HSP 1 Score: 207.223 bits (526), Expect = 4.434e-54 Identity = 186/598 (31.10%), Postives = 294/598 (49.16%), Query Frame = 1
Query: 127 NLINDLSDDAFSCSSFRDN---FFPYLAREKNSKNRMIDSP----QAWCPKNEVGPNSKEYIQVDFKDLKALSYLVTNGLDNGNDGFFVSFFYLDYQRENGSGWHRYKNETDHKLIEGNVDSRNMKITKFKXXXXXXXXXXXXXXXXTKT-VCLKFTFYGGNFNDGVVEYSMPQGDIFTIYQ--IKFPLKDRIYDG---IEHRKNDNVLRRGIGQLMDXXXXXXXXXXXXXGEV---NFVGW-QNFDKNRKIEMIFRFDKVRIMKGVSFHILNDLKKNISIFSSARFEFSIGGEIYGKCAKNITFKHNADLKLKTARWLHVNLSDSPAKFVRVTLEFRLQWIVLTEV-----QFTTNVPKEE------YPTEKQGSDTR---SKSKPNSMFPTSKINNLL----ICFCVIITFVGLMCIISICILXXXXXXXXXI-------------KGK---PLHSIRYGNMP-INNVIPIPVV-----SSSNGGIYKPIPNGV-----YDCMPGFQSQTLNVRKVTNYPNQQLFGTYSNRKNSNSNQNPGIAPINQDN--YNA--TLSQIVGQPNVALYCPENKRASYDGSYGTSSNPEYSNGSL 1722
NL+ +L +++F SS F P+ AR K +D P AWCPK + + +E+I++D DLK + L T G +GN + FYLDYQR +G W RY+N+ +L+ GN D+RN+ +T F+S IIARRIRI PIS + C++ YG +F+DGVVEYS+ QG +T K+ L+D YDG I+ +L G+GQLMDN+I I+ +N ++ +FVGW + F + K+E++ +FD++R +K + F+ +N + ++I +FSSA FS GG Y + + FK D ++ RW+++ L + A+F+++ L F + WI+L+E+ ++ +PKE YP + + + S + P + NN + + +GL+ IS C L F + KGK P++ R P I + + +P+ SS G Y P V Y M G + TL+ + T+Y + N G+ P + YN + + +GQ + R S DGS G SSN +Y++ SL
Sbjct: 47 NLVANLKNESFIASSVWKEIVEFEPHQARMKQ-----MDDPNLLGHAWCPKQMIKSSPEEWIEIDLGDLKMIKNLATAGRGDGNFAEYAPHFYLDYQRVSGK-WIRYRNQRKEQLLNGNTDARNVAMTNFESMIIARRIRIYPISKEKQIRACMRIIIYGCDFDDGVVEYSVSQGHYYTARNGNEKYDLRDLTYDGVISIDKSNPKGLLEEGLGQLMDNVIYNGVISEDHNNKIRGYHFVGWNRKFLDSNKVEIVMKFDQMRSVKQIRFYAMNMIPEDIGVFSSAIIHFSRGGVYYDRISPAYQFKTVIDTRVYYPRWINITLQNVLARFLKIDLFFEVDWIILSEIVIISEKYNEIIPKESESIQTNYPITHNITSVKYIPTDSTATVLIPQNGKNNHIDTNRSSSFTASSSLGLIATISSCFLGFVFLIALIVFGVFTLRRHKKRTKGKLRNPIYQTRINGGPFIGDSVVVPLTGGTQSSSGTGSFYYKYPGNVELGLTYPVM-GKEYMTLSSKSGTDY------------DMAGGNSLDGLIPTGTRDIKYNGMNSYAPPMGQNDSPYPTNIYSRNSADGSTGGSSNTDYASTSL 625 HSP 2 Score: 138.658 bits (348), Expect = 1.022e-32 Identity = 94/275 (34.18%), Postives = 137/275 (49.82%), Query Frame = 1
Query: 2617 LIYIAAQISDGMSFLEHEGLIHRDLATRNCIVGPRLSILITDTAMDNNKFQKDYITINKVLSDLSTIGM----DIDVNINFYQPSVSLPLQWMSWEAVLKGRYSSKSDVWSFGVLFWDLLTFCQFRPYFCVPQNLTNIDSTANYVKCLSLLFNFKCLEHGLDNSLMPNNESLSQIRKGTSWTTPLPLPVPSQIINISSDRRLANIQTPRMTHQDSSVNRILDSNREIRDLISSCWSTEPSNRPKFKDISIFLKQKINNFNVEEEYQYIQTNVRRS 3429
L++I QI+ GMS+LE +IHRDLA RNC++G L I ITD AM KF++ YI + + +G+ D D N + PLQWM++E++L+ YS K+D+WSFGV W++L CQ PY + I A +N L G +++ P NE+L P SQ N + +AN + + H+D L +R+ DLI CW+ P RP FK IS L+QKI NF ++ + + + S
Sbjct: 943 LLFIITQIARGMSYLESRQIIHRDLAARNCLIGQNLKIKITDIAMSIQKFKEHYI-------ECAVVGIQKNEDCDSNSSISVVKRFYPLQWMAFESILQATYSCKTDIWSFGVTMWEILHRCQQTPYGGFAISFDRIRDNA---------YN---LSIGNSSAVFP-NENL--------------YPHQSQ-SNFRPSQHMAN-PSSSILHED------LGLSRDFSDLIQECWNRNPHQRPTFKLISSILEQKITNFEFANDHSNLFSTINNS 1175 The following BLAST results are available for this feature:
BLAST of Discoidin domain-containing receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Discoidin domain-containing receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Discoidin domain-containing receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004881 ID=SMED30004881|Name=Discoidin domain-containing receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=3653bpback to top protein sequence of SMED30004881-orf-1 >SMED30004881-orf-1 ID=SMED30004881-orf-1|Name=SMED30004881-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1140bp MFNKMGAELNIQFVIFVLLTGFIFSQFLPSFRGKDTNYNLINDLSDDAFSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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