PWWP domain-containing protein

Overview


Name	PWWP domain-containing protein
Smed ID	SMED30004856
Length (bp)	1933

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of PWWP domain-containing protein (SMED30004856) t-SNE clustered cells

Violin plots show distribution of expression levels for PWWP domain-containing protein (SMED30004856) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PWWP domain-containing protein (SMED30004856) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PWWP domain-containing protein (SMED30004856) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30004856

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30004856	h1SMcG0013416	dd_Smed_v4_8454_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30004856	h1SMcG0013416	dd_Smed_v4_8454_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30004856	h1SMcG0013416	dd_Smed_v4_8454_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30004856	h1SMcG0013416	dd_Smed_v4_8454_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30004856	h1SMcG0013416	dd_Smed_v4_8454_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of PWWP domain-containing protein vs. Ensembl Human
Match: PWWP2A (PWWP domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29406])

HSP 1 Score: 68.1662 bits (165), Expect = 3.540e-11
Identity = 39/109 (35.78%), Postives = 57/109 (52.29%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W      S++  + LS F  +F ++F+ K K    K   EA   AKQLT E
Sbjct:  644 KCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRK-------DNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPE 745

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Human
Match: PWWP2B (PWWP domain containing 2B [Source:HGNC Symbol;Acc:HGNC:25150])

HSP 1 Score: 60.077 bits (144), Expect = 8.998e-9
Identity = 37/118 (31.36%), Postives = 59/118 (50.00%), Query Frame = 2

Query:  332 LNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            +  + Q + +C   D R  A+ DIVW KI G+P+WP+++L I+  QK     + + +  E   A V W      S+++ + LS F   F  +F+ K K    K   EA N A+ +  E
Sbjct:  470 VRLHTQSVSECITEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQK----EDGEPSWRE---AKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANAARHVAPE 580

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BLAST of PWWP domain-containing protein vs. Ensembl Zebrafish
Match: CU855895.3 (pep chromosome:GRCz11:21:30025031:30030644:-1 gene:ENSDARG00000114922.1 transcript:ENSDART00000190810.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CU855895.3)

HSP 1 Score: 67.0106 bits (162), Expect = 2.769e-12
Identity = 39/111 (35.14%), Postives = 56/111 (50.45%), Query Frame = 2

Query:  353 LIKC-KLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            + KC  L  R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A V W      S++    L+ F  +F ++F  K K    K   EA   AKQLT E
Sbjct:   81 VTKCVALDGRTICVGDIVWAKILGFPWWPARILAITVSRK-------DNGLLVRQEARVSWFGSPTTSFLAITQLAPFLENFQSRFDKKRKGLYRKAITEAAKAAKQLTPE 184

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BLAST of PWWP domain-containing protein vs. Ensembl Zebrafish
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 55.8398 bits (133), Expect = 1.348e-7
Identity = 33/111 (29.73%), Postives = 56/111 (50.45%), Query Frame = 2

Query:  332 LNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQ 661
            +  + + + KC   D     + D+VW KI G+P+WP++ILSI+ +++  +     +   E   A V W      S ++ A LS F   F ++F+ K K   Y  A+ EA +
Sbjct:  475 VRLHTRSMSKCVTEDGHAVTVGDVVWGKIHGFPWWPARILSISGTRR--EDGEVDAPWPE---AKVSWFGSPTTSELSVAKLSPFREFFRSRFNRK-KKGMYRRAIMEAAK 579

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BLAST of PWWP domain-containing protein vs. Ensembl Xenopus
Match: PWWP2A (PWWP domain containing 2A [Source:NCBI gene;Acc:100145656])

HSP 1 Score: 67.3958 bits (163), Expect = 5.692e-11
Identity = 38/109 (34.86%), Postives = 57/109 (52.29%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W      S++  + L+ F  +F ++F+ K K    K   EA   AKQLT E
Sbjct:  676 KCVTPDGRTICVGDIVWAKIYGFPWWPARILAITVSRK-------DTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPE 777

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BLAST of PWWP domain-containing protein vs. Ensembl Mouse
Match: Pwwp2a (PWWP domain containing 2A [Source:MGI Symbol;Acc:MGI:1918052])

HSP 1 Score: 65.4698 bits (158), Expect = 1.482e-10
Identity = 39/109 (35.78%), Postives = 56/109 (51.38%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W A    S +  + LS F  +F  +F+ K K    +   EA   AKQLT E
Sbjct:  619 KCITPDGRTICVGDIVWAKIYGFPWWPARILTITVSRK-------DNGLLARQEARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPE 720

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Mouse
Match: Pwwp2a (PWWP domain containing 2A [Source:MGI Symbol;Acc:MGI:1918052])

HSP 1 Score: 63.929 bits (154), Expect = 2.923e-10
Identity = 39/109 (35.78%), Postives = 56/109 (51.38%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W A    S +  + LS F  +F  +F+ K K    +   EA   AKQLT E
Sbjct:  344 KCITPDGRTICVGDIVWAKIYGFPWWPARILTITVSRK-------DNGLLARQEARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPE 445

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Mouse
Match: Pwwp2b (PWWP domain containing 2B [Source:MGI Symbol;Acc:MGI:2142008])

HSP 1 Score: 63.5438 bits (153), Expect = 5.222e-10
Identity = 38/121 (31.40%), Postives = 61/121 (50.41%), Query Frame = 2

Query:  332 LNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIR 691
            +  + Q + +C   D R  A+ DIVW KI G+P+WP+++L I+  QK     + + +  E   A V W      S+++ + LS F   F  +F+ K K   Y +A+ EA   T+     IR
Sbjct:  480 VRLHTQSVSRCVTEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQK----EDGEPSWQE---AKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRK-KKGMYRKAITEAANATQHVAPEIR 592

[Close]

Query:  332 LNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIR 691
            +  + Q + +C   D R  A+ DIVW KI G+P+WP+++L I+  QK     + + +  E   A V W      S+++ + LS F   F  +F+ K K   Y +A+ EA   T+     IR
Sbjct:  480 VRLHTQSVSRCVTEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQK----EDGEPSWQE---AKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRK-KKGMYRKAITEAANATQHVAPEIR 592

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BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q96N64|PWP2A_HUMAN (PWWP domain-containing protein 2A OS=Homo sapiens OX=9606 GN=PWWP2A PE=1 SV=2)

HSP 1 Score: 68.1662 bits (165), Expect = 1.700e-10
Identity = 39/109 (35.78%), Postives = 57/109 (52.29%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W      S++  + LS F  +F ++F+ K K    K   EA   AKQLT E
Sbjct:  644 KCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRK-------DNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPE 745

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BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Match: sp|F7AQ22|PWP2A_XENTR (PWWP domain-containing protein 2A OS=Xenopus tropicalis OX=8364 GN=pwwp2a PE=2 SV=2)

HSP 1 Score: 67.0106 bits (162), Expect = 3.252e-10
Identity = 38/109 (34.86%), Postives = 57/109 (52.29%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W      S++  + L+ F  +F ++F+ K K    K   EA   AKQLT E
Sbjct:  673 KCVTPDGRTICVGDIVWAKIYGFPWWPARILAITVSRK-------DTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPE 774

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BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Match: sp|A0A1L8GR68|PWP2A_XENLA (PWWP domain-containing protein 2A OS=Xenopus laevis OX=8355 GN=pwwp2a PE=3 SV=2)

HSP 1 Score: 66.2402 bits (160), Expect = 6.878e-10
Identity = 38/109 (34.86%), Postives = 57/109 (52.29%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W      S++  + L+ F  +F ++F+ K K    K   EA   AKQLT E
Sbjct:  673 KCVTPDGRTICVGDIVWAKIYGFPWWPARILAITISRK-------DNGLLIRQEARISWFGSPTTSFLALSQLAPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPE 774

[Close]

BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q69Z61|PWP2A_MOUSE (PWWP domain-containing protein 2A OS=Mus musculus OX=10090 GN=Pwwp2a PE=2 SV=2)

HSP 1 Score: 65.4698 bits (158), Expect = 1.037e-9
Identity = 39/109 (35.78%), Postives = 56/109 (51.38%), Query Frame = 2

Query:  359 KCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC   D R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A + W A    S +  + LS F  +F  +F+ K K    +   EA   AKQLT E
Sbjct:  619 KCITPDGRTICVGDIVWAKIYGFPWWPARILTITVSRK-------DNGLLARQEARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPE 720

[Close]

BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NUJ5|PWP2B_HUMAN (PWWP domain-containing protein 2B OS=Homo sapiens OX=9606 GN=PWWP2B PE=1 SV=3)

HSP 1 Score: 60.077 bits (144), Expect = 4.321e-8
Identity = 37/118 (31.36%), Postives = 59/118 (50.00%), Query Frame = 2

Query:  332 LNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            +  + Q + +C   D R  A+ DIVW KI G+P+WP+++L I+  QK     + + +  E   A V W      S+++ + LS F   F  +F+ K K    K   EA N A+ +  E
Sbjct:  470 VRLHTQSVSECITEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQK----EDGEPSWRE---AKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANAARHVAPE 580

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BLAST of PWWP domain-containing protein vs. TrEMBL
Match: A0A3P8J9P6 (PWWP domain-containing protein OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS10429 PE=4 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 1.903e-14
Identity = 44/121 (36.36%), Postives = 72/121 (59.50%), Query Frame = 2

Query:  350 PLIK-CKLSDRE-FAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEE-----------YIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEE 673
            PL+K CKL+D   F + D+VW+K+SG+P+WP++I SI R     +P++ +   + +           ++AC+ W A+ Q+SY+ C  L HF ++   +F  K K   + +AVNEAKQ  E+
Sbjct:  718 PLVKRCKLADDVVFRVGDLVWSKLSGWPYWPAQITSIQRIGSEVEPSSLEKEPVTKDSHEKISEQVCFVACLHWFAWHQVSYMPCDKLYHF-LEHCKRFDNKKKRGVFRQAVNEAKQAAEK 837

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BLAST of PWWP domain-containing protein vs. TrEMBL
Match: A0A183WE76 (PWWP domain-containing protein OS=Trichobilharzia regenti OX=157069 PE=4 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 1.903e-14
Identity = 44/121 (36.36%), Postives = 72/121 (59.50%), Query Frame = 2

Query:  350 PLIK-CKLSDRE-FAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEE-----------YIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEE 673
            PL+K CKL+D   F + D+VW+K+SG+P+WP++I SI R     +P++ +   + +           ++AC+ W A+ Q+SY+ C  L HF ++   +F  K K   + +AVNEAKQ  E+
Sbjct:  718 PLVKRCKLADDVVFRVGDLVWSKLSGWPYWPAQITSIQRIGSEVEPSSLEKEPVTKDSHEKISEQVCFVACLHWFAWHQVSYMPCDKLYHF-LEHCKRFDNKKKRGVFRQAVNEAKQAAEK 837

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BLAST of PWWP domain-containing protein vs. TrEMBL
Match: A0A0R3VSI9 (PWWP domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS132 PE=4 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 1.549e-13
Identity = 101/354 (28.53%), Postives = 148/354 (41.81%), Query Frame = 2

Query:  152 PLNRKTRT----KKSKLLHVDDHSESSSEFNPPLKLKLIRDQS--DP---KTF-------KSIQIIN------DFSQASDYYLNFNQQPLIKCKLSDREFAINDIVWAKISGYPFWPSKI--LSINRSQKCAQ--PNNCKS------------AVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIRLFSSNDT-INNHKQVDSVHSCETLEGETS-STLPSHNFTSPESNQSLQSCCLSRPTGVMS-DPLSNQSDRSSHSNIEFPHTSDSQISISIPLLKSKFEAEKLAAPTH-WD-LPDLGSNLDFESNNHIPEFSDYEDE 1084
            P++RK ++    K  +   V   S SS+     LK++L RD S  +P   K F       KS+Q+        D           N    +    +   F + D+VWAK++GYP+WPS+I  L      + AQ  P N  S            A+   + A VEW A++Q SY++CA L  F   F   +S + + K Y EAVN AK + E      RL S   + I          S  T  G ++ S  P  +F     N+  QS  L  P   ++ DP++ Q    S   +E  H S   +  +          +   AP   W  LP L  +   E N+ +P FS+ EDE
Sbjct:  241 PVSRKRQSRLDSKARENCSVPQPSTSSAFLTGGLKIRLRRDVSVDEPICGKKFRSRKSNQKSVQVFRIVESWCDADAPGGLAAKSNAVSPMSTNQTSGGFRVGDVVWAKLAGYPYWPSRISALYARTPHQLAQVSPENANSDSLAVSATPADPALAPGFTAKVEWFAWNQCSYLSCAKLFPFMEYFAKLYSPRTRVKNYAEAVNMAKLVVEGGSNETRLISEPQSDIKKGSSASLSLSNNTEHGRSNLSCPPDLHFAFNPLNEPKQSDVLRLPDLRLAFDPVNPQLPVGSQVPVENGHFSFLNLGAN--------SGDFCQAPDQCWGPLPQLDVSGLNEFNSGVPTFSEDEDE 586

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BLAST of PWWP domain-containing protein vs. TrEMBL
Match: A0A504YUG3 (PWWP domain-containing protein 2A OS=Fasciola gigantica OX=46835 GN=FGIG_02827 PE=4 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 2.393e-13
Identity = 51/139 (36.69%), Postives = 76/139 (54.68%), Query Frame = 2

Query:  359 KCKLSDRE-FAINDIVWAKISGYPFWPSKILSINRS--------QKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIRLFSSNDTINNHKQVDSVHS 748
            +CKL D   F + D+VW+K+SG+P+WP++I SI++S            Q  + KS V   Y AC+ W A+ Q+SY+ C  L HF   +  +F  K K   + +AVNEA Q  +E    I   S  D+   ++ VD +HS
Sbjct:  801 RCKLPDGVVFRVGDLVWSKLSGWPYWPAQITSIHQSVVDEQEINPDVIQQPDTKSIV---YTACLHWFAWHQVSYMTCDKLYHFMQHY-RRFDNKRKRGVFRQAVNEACQAADEKRNEISSSSDADSGLENENVD-IHS 934

[Close]

BLAST of PWWP domain-containing protein vs. TrEMBL
Match: A0A4E0RA01 (PWWP domain-containing protein 2A OS=Fasciola hepatica OX=6192 GN=D915_006020 PE=4 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 2.653e-13
Identity = 49/135 (36.30%), Postives = 74/135 (54.81%), Query Frame = 2

Query:  359 KCKLSDRE-FAINDIVWAKISGYPFWPSKILSINRS--------QKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIRLFSSNDTINNHKQVD 736
            +CKL D   F + D+VW+K+SG+P+WP++I SI++S            Q ++ KS V   Y AC+ W A+ Q+SY+ C  L HF   +  +F  K K   + +AVNEA Q  +E    I   S  D+   ++ VD
Sbjct:  801 RCKLPDGVVFRVGDLVWSKLSGWPYWPAQITSIHQSVVDEQEINPDVIQQSDTKSIV---YTACLHWFAWHQVSYMTCDKLYHFMQHY-RRFDNKRKRGVFRQAVNEACQAADEKRNEISSSSDADSGLENENVD 931

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Cavefish
Match: pwwp2a (PWWP domain containing 2A [Source:NCBI gene;Acc:103027727])

HSP 1 Score: 68.1662 bits (165), Expect = 1.825e-11
Identity = 39/109 (35.78%), Postives = 55/109 (50.46%), Query Frame = 2

Query:  359 KC-KLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKN---KKYFEAVNEAKQLTEE 673
            KC  L  R   + DIVWAKI G+P+WP++IL+I  S+K        + ++    A V W      S++    L+ F  +F ++F  K K    K   EA   AKQLT E
Sbjct:  912 KCVALDGRTICVGDIVWAKILGFPWWPARILAITVSRK-------DNGLLVRQEARVSWFGSPTTSFLAITQLAPFLENFQSRFDKKRKGLYRKAITEAAKAAKQLTPE 1013

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Cavefish
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 54.6842 bits (130), Expect = 2.326e-7
Identity = 33/102 (32.35%), Postives = 49/102 (48.04%), Query Frame = 2

Query:  383 FAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRI 688
              + D+VW KI G+P+WP+++LSIN S++        +   E   A V W      S ++ A LS F   F  +F+ K K   Y  A+ EA +      T I
Sbjct:  478 VTVGDVVWGKIHGFPWWPARVLSINGSRR--DEGEMDAPWPE---AKVSWFGSPTTSQLSVAKLSPFREFFRLRFNRK-KKGMYRRAIIEAAKAVGHMSTEI 573

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Sea Lamprey
Match: pwwp2b (PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GENE-110930-2])

HSP 1 Score: 60.4622 bits (145), Expect = 6.310e-10
Identity = 31/108 (28.70%), Postives = 50/108 (46.30%), Query Frame = 2

Query:  374 DREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIRLF 697
             R+  + D+VWAKI G+P+WP+ +L ++       P        E   A V W      S V+ A L+ F   F  +   K K  +Y +AV EA + T+     ++ +
Sbjct:  378 GRKVHVGDVVWAKIHGFPWWPACVLGLS-------PELGPGGQQESGEALVSWFGSHTTSAVSLAKLAPFQESFRARLDRKRKG-RYRQAVAEAARATKRLTAEVKAW 477

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001585.1 (pep scaffold:Pmarinus_7.0:GL478812:497860:498661:1 gene:ENSPMAG00000001433.1 transcript:ENSPMAT00000001585.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.9062 bits (115), Expect = 2.231e-7
Identity = 26/101 (25.74%), Postives = 52/101 (51.49%), Query Frame = 2

Query:  389 INDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIR 691
            + DIVWAK+ G P+WP+++ S++ S +       +S ++    A + W      S++  +    F  +F+ ++S + K+  Y  AV+EA + +      +R
Sbjct:   26 VGDIVWAKLHGCPWWPAQVRSVSVSVQ------EESGLVLSQEAKMAWFGSTTTSFLPLSQAVPFMENFEARYSRRKKSNGYRRAVSEAAEASRRLTPEVR 120

[Close]

BLAST of PWWP domain-containing protein vs. Ensembl Medaka
Match: pwwp2b (PWWP domain containing 2B [Source:NCBI gene;Acc:101155875])

HSP 1 Score: 63.5438 bits (153), Expect = 4.776e-10
Identity = 37/129 (28.68%), Postives = 65/129 (50.39%), Query Frame = 2

Query:  278 TFKSIQIINDFSQASDYYLNFNQQPLIKCKLSD-REFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQ 661
            T  S+   +D        +  + + + KC   +    A+ DIVW KI G+P+WP+++LSI+ ++K   P +C++   +  +A   W      S ++ A LS F   F ++F+ K K   Y  A+ EA +
Sbjct:  485 TSSSVTPQDDCKTVPPLTVRLHTRSMTKCVTEEGHAVAVGDIVWGKIHGFPWWPARVLSISGTRKQEMP-SCEAQWPQAKVA---WFGSPTTSQLSVAKLSPFRELFRSRFNRK-KKGMYRRAILEAAK 608

[Close]

BLAST of PWWP domain-containing protein vs. Planmine SMEST
Match: SMESG000068720.1 (SMESG000068720.1)

HSP 1 Score: 712.605 bits (1838), Expect = 0.000e+0
Identity = 364/366 (99.45%), Postives = 366/366 (100.00%), Query Frame = 2

Query:   41 MDVYDFSERDDQSNXXXXXXXXXXXXXXDSTLVTKIRPLNRKTRTKKSKLLHVDDHSESSSEFNPPLKLKLIRDQSDPKTFKSIQIINDFSQASDYYLNFNQQPLIKCKLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIRLFSSNDTINNHKQVDSVHSCETLEGETSSTLPSHNFTSPESNQSLQSCCLSRPTGVMSDPLSNQSDRSSHSNIEFPHTSDSQISISIPLLKSKFEAEKLAAPTHWDLPDLGSNLDFESNNHIPEFSDYEDEFESIDIEKIKFLVDVENN 1138
            MDVYDFSERDDQSNIQSKNIKHKKRKIKDSTLVTKIRPLNRKTRTKKSKLLHVDDHSESSSEFNPPLKLKLIRDQSDPKTFKSIQIINDFSQASDYYLNFNQQPLIKCKLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRI+LFSSNDTINNHKQVDSVHSCETLEGETSSTLPSHNFTSPESNQSLQSCCLSRPTG+MSDPLSNQSDRSSHSNIEFPHTSDSQISISIPLLKSKFEAEKLAAPTHWDLPDLGSNLDFESNNHIPEFSDYEDEFESIDIEKIKFLVDVENN
Sbjct:    1 MDVYDFSERDDQSNIQSKNIKHKKRKIKDSTLVTKIRPLNRKTRTKKSKLLHVDDHSESSSEFNPPLKLKLIRDQSDPKTFKSIQIINDFSQASDYYLNFNQQPLIKCKLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAKQLTEENITRIKLFSSNDTINNHKQVDSVHSCETLEGETSSTLPSHNFTSPESNQSLQSCCLSRPTGIMSDPLSNQSDRSSHSNIEFPHTSDSQISISIPLLKSKFEAEKLAAPTHWDLPDLGSNLDFESNNHIPEFSDYEDEFESIDIEKIKFLVDVENN 366

[Close]

BLAST of PWWP domain-containing protein vs. Planmine SMEST
Match: SMESG000059612.1 (SMESG000059612.1)

HSP 1 Score: 87.4261 bits (215), Expect = 1.073e-17
Identity = 37/92 (40.22%), Postives = 58/92 (63.04%), Query Frame = 2

Query:  383 FAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAK 658
            F ++D+VWAKI+GYPFWP+KI+S ++ +             + +I C+EW A+++IS++   NL HF  +F  K+  + +N KY EAV  AK
Sbjct:  518 FNLSDVVWAKITGYPFWPAKIISFSQEE-------------DTFIGCIEWYAWNEISFIKVNNLHHFSTNFPTKYQKRYRNGKYQEAVKLAK 596

[Close]

BLAST of PWWP domain-containing protein vs. Planmine SMEST
Match: SMESG000031464.1 (SMESG000031464.1)

HSP 1 Score: 68.5514 bits (166), Expect = 7.749e-12
Identity = 36/93 (38.71%), Postives = 53/93 (56.99%), Query Frame = 2

Query:  380 EFAINDIVWAKISGYPFWPSKILSI-NRSQKCAQPNNCKSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEA 655
            +F+IN+IVWAKI GYPFWP+ I S  N S   +Q   C+          + W+ ++Q S++   +L HF   F  K+S K K++KY  A+  A
Sbjct:  324 KFSINNIVWAKIPGYPFWPAHIKSFDNVSASKSQGKRCR----------INWIGWNQKSFLPLKSLLHFEEHFKMKYSAKFKSQKYKTAIELA 406

[Close]

BLAST of PWWP domain-containing protein vs. Planmine SMEST
Match: SMESG000027963.1 (SMESG000027963.1)

HSP 1 Score: 53.5286 bits (127), Expect = 3.626e-7
Identity = 44/146 (30.14%), Postives = 69/146 (47.26%), Query Frame = 2

Query:  242 KLKLIRDQSDPKTFKSIQIINDFSQASDYY--LNFNQQPLIKCKLSDR----EFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNCKSAVIEEYIACVEWLAYD-QISYVNCANLSHFHIDFDNKFSTKIKNKKYFEAVNEAK 658
            KLK++++ S P  +    II    + S+     + N  P+ K     R    +F+I D+VWAK+SGY  WP+K++ ++       PNN  + V+        WL  D + S +    L  F   F  KF+ K K   Y  AV +A+
Sbjct:  284 KLKIVKNGSKPNCY----IIKPAEKISNTTNPKSVNDIPICKINTKSRYNCKKFSIGDVVWAKLSGYSIWPAKVIDLD-------PNNDNATVM--------WLGDDYRTSQLARYKLWDFRAHFQEKFNKKGKG-NYMAAVQQAQ 409

The following BLAST results are available for this feature:

BLAST of PWWP domain-containing protein vs. Ensembl Human
BLAST of PWWP domain-containing protein vs. Ensembl Celegans
BLAST of PWWP domain-containing protein vs. Ensembl Fly
BLAST of PWWP domain-containing protein vs. Ensembl Zebrafish
BLAST of PWWP domain-containing protein vs. Ensembl Xenopus
BLAST of PWWP domain-containing protein vs. Ensembl Mouse
BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
BLAST of PWWP domain-containing protein vs. TrEMBL
BLAST of PWWP domain-containing protein vs. Ensembl Cavefish
BLAST of PWWP domain-containing protein vs. Ensembl Sea Lamprey
BLAST of PWWP domain-containing protein vs. Ensembl Yeast
BLAST of PWWP domain-containing protein vs. Ensembl Nematostella
BLAST of PWWP domain-containing protein vs. Ensembl Medaka
BLAST of PWWP domain-containing protein vs. Planmine SMEST

BLAST of PWWP domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
PWWP2A	3.540e-11	35.78	PWWP domain containing 2A [Source:HGNC Symbol;Acc:...	[more]
PWWP2B	8.998e-9	31.36	PWWP domain containing 2B [Source:HGNC Symbol;Acc:...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CU855895.3	2.769e-12	35.14	pep chromosome:GRCz11:21:30025031:30030644:-1 gene...	[more]
pwwp2b	1.348e-7	29.73	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
PWWP2A	5.692e-11	34.86	PWWP domain containing 2A [Source:NCBI gene;Acc:10...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Pwwp2a	1.482e-10	35.78	PWWP domain containing 2A [Source:MGI Symbol;Acc:M...	[more]
Pwwp2a	2.923e-10	35.78	PWWP domain containing 2A [Source:MGI Symbol;Acc:M...	[more]
Pwwp2b	5.222e-10	31.40	PWWP domain containing 2B [Source:MGI Symbol;Acc:M...	[more]
Pwwp2b	5.222e-10	31.40	PWWP domain containing 2B [Source:MGI Symbol;Acc:M...	[more]

BLAST of PWWP domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q96N64\|PWP2A_HUMAN	1.700e-10	35.78	PWWP domain-containing protein 2A OS=Homo sapiens ...	[more]
sp\|F7AQ22\|PWP2A_XENTR	3.252e-10	34.86	PWWP domain-containing protein 2A OS=Xenopus tropi...	[more]
sp\|A0A1L8GR68\|PWP2A_XENLA	6.878e-10	34.86	PWWP domain-containing protein 2A OS=Xenopus laevi...	[more]
sp\|Q69Z61\|PWP2A_MOUSE	1.037e-9	35.78	PWWP domain-containing protein 2A OS=Mus musculus ...	[more]
sp\|Q6NUJ5\|PWP2B_HUMAN	4.321e-8	31.36	PWWP domain-containing protein 2B OS=Homo sapiens ...	[more]

BLAST of PWWP domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3P8J9P6	1.903e-14	36.36	PWWP domain-containing protein OS=Trichobilharzia ...	[more]
A0A183WE76	1.903e-14	36.36	PWWP domain-containing protein OS=Trichobilharzia ...	[more]
A0A0R3VSI9	1.549e-13	28.53	PWWP domain-containing protein OS=Taenia asiatica ...	[more]
A0A504YUG3	2.393e-13	36.69	PWWP domain-containing protein 2A OS=Fasciola giga...	[more]
A0A4E0RA01	2.653e-13	36.30	PWWP domain-containing protein 2A OS=Fasciola hepa...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pwwp2a	1.825e-11	35.78	PWWP domain containing 2A [Source:NCBI gene;Acc:10...	[more]
pwwp2b	2.326e-7	32.35	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
pwwp2b	6.310e-10	28.70	PWWP domain containing 2B [Source:ZFIN;Acc:ZDB-GEN...	[more]
ENSPMAT00000001585.1	2.231e-7	25.74	pep scaffold:Pmarinus_7.0:GL478812:497860:498661:1...	[more]

BLAST of PWWP domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PWWP domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pwwp2b	4.776e-10	28.68	PWWP domain containing 2B [Source:NCBI gene;Acc:10...	[more]

BLAST of PWWP domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000068720.1	0.000e+0	99.45	SMESG000068720.1	[more]
SMESG000059612.1	1.073e-17	40.22	SMESG000059612.1	[more]
SMESG000031464.1	7.749e-12	38.71	SMESG000031464.1	[more]
SMESG000027963.1	3.626e-7	30.14	SMESG000027963.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30004856 ID=SMED30004856|Name=PWWP domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1933bp
CTTATATGACAAAAATGAATGTCTAAATTGTTGACTGAAAATGGATGTTT
ACGACTTTTCAGAGCGTGACGATCAGTCAAATATTCAAAGTAAAAATATA
AAGCATAAAAAGAGAAAAATTAAGGATAGTACACTTGTAACTAAAATACG
ACCACTAAATCGGAAAACTCGAACTAAAAAGTCAAAACTTCTTCATGTTG
ACGACCATTCAGAAAGCAGTTCTGAATTTAATCCACCTCTCAAATTAAAA
CTAATTCGTGATCAAAGTGATCCGAAAACCTTTAAATCGATACAAATTAT
TAATGATTTTTCTCAAGCTTCTGATTATTATTTAAACTTTAATCAGCAAC
CACTAATCAAATGTAAATTATCGGACAGAGAATTTGCCATTAATGATATT
GTTTGGGCAAAAATCAGCGGATATCCATTTTGGCCTTCTAAAATACTATC
AATAAATCGATCACAAAAATGTGCTCAACCAAATAATTGTAAATCAGCAG
TGATCGAAGAATATATTGCCTGCGTTGAATGGCTCGCGTATGATCAAATA
TCTTATGTTAACTGTGCCAATCTTTCACATTTTCATATTGATTTCGATAA
TAAATTCAGCACTAAAATAAAAAATAAGAAATATTTTGAAGCTGTTAATG
AAGCTAAACAGTTAACCGAAGAAAACATAACTAGAATAAGATTATTTTCT
TCAAATGATACCATTAATAATCACAAACAAGTGGACAGTGTTCATTCATG
TGAAACCCTTGAAGGGGAAACAAGCAGTACTTTGCCGAGTCATAATTTTA
CCAGCCCAGAGAGTAATCAATCTCTACAATCCTGCTGCCTTTCTCGACCA
ACCGGGGTAATGTCTGATCCGTTATCCAATCAATCAGATCGTTCATCCCA
TAGTAACATTGAATTTCCTCACACCTCCGATTCTCAAATTTCAATTTCTA
TTCCTTTATTAAAATCAAAGTTTGAAGCCGAAAAATTAGCTGCTCCGACA
CATTGGGATTTACCTGATTTAGGGAGCAATTTAGATTTTGAAAGTAACAA
CCACATTCCGGAATTTTCTGATTACGAAGACGAATTTGAAAGTATTGATA
TTGAAAAAATCAAATTTCTAGTAGACGTGGAAAATAATTAGAAAAAATTT
CAAAAAATGTGGTTTCAATTTAAAGTAATTTGTTCATAAAAATTGGTATT
GATTCGGCTTTGCCTTATTAATATCTGTTTTCTTTGCGTTGTAATGGGGG
ATTTGCTTGTTTTCATTTTCAACTTTGCCCTTTCAGATGATTATTTGTTA
AGATGGTTATTAATTTTCCTCAGAATTTCTTCAAGTGATTTCAAAATAGC
ACTATTGTATCTGTTATCAGATTATAAAAAATCAATTTATTTCAATGCAC
TTTCTATTAAAAATTCAATTACAAATTTAATCAATATTCGTATTAGAATG
TTTGAATTATCCTCGGTAAATTATCTTAATTTCTTTCTTATTATATAAAA
TATAGTCATAATGAATTATTTTAACAGGAAAATTTTGGCAGGATTTGTTT
TGACGGCATAATTATCTATTTTACACTGTGTGTACTGTATTTATGAATTT
TGTACATTTGCTCTACTGATTGTGATTTGGCGCATTTGTGTGTTTGTAAT
TCATTTTCTTAATGTAATGTTATTATTTAAAATACCTGACAGATGTTTGT
GTATATAAATAGGTTTTGCATAAAACAAGTGGTCGTTTATGCGACATGTT
TTCATGGGGATTGTGTTAAATTCGTCAATATTTTTTACACAAAATGCTTT
TTATAAGTTTCGATATGCTGTTTTTTATTATTACAACTCACCTTGTAAAT
AAGTTGATGCATCTATAATAAATAACGATTTGGTATATTAATAGTAATTT
TCCTGATTGTTTTAAATTTGCATTATTTTTTGT

protein sequence of SMED30004856-orf-1

>SMED30004856-orf-1 ID=SMED30004856-orf-1|Name=SMED30004856-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=367bp
MDVYDFSERDDQSNIQSKNIKHKKRKIKDSTLVTKIRPLNRKTRTKKSKL
LHVDDHSESSSEFNPPLKLKLIRDQSDPKTFKSIQIINDFSQASDYYLNF
NQQPLIKCKLSDREFAINDIVWAKISGYPFWPSKILSINRSQKCAQPNNC
KSAVIEEYIACVEWLAYDQISYVNCANLSHFHIDFDNKFSTKIKNKKYFE
AVNEAKQLTEENITRIRLFSSNDTINNHKQVDSVHSCETLEGETSSTLPS
HNFTSPESNQSLQSCCLSRPTGVMSDPLSNQSDRSSHSNIEFPHTSDSQI
SISIPLLKSKFEAEKLAAPTHWDLPDLGSNLDFESNNHIPEFSDYEDEFE
SIDIEKIKFLVDVENN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0002056	medial muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000313	PWWP_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:2.30.30.140		coord: 107..223 e-value: 6.7E-20 score: 73.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..18
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..26
None	No IPR available	PANTHER	PTHR23068	DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED	coord: 10..228
None	No IPR available	PANTHER	PTHR23068:SF30		coord: 10..228
None	No IPR available	SUPERFAMILY	SSF63748	Tudor/PWWP/MBT	coord: 111..217
IPR000313	PWWP domain	PFAM	PF00855	PWWP	coord: 115..208 e-value: 5.8E-12 score: 45.9
IPR000313	PWWP domain	PROSITE	PS50812	PWWP	coord: 117..137 score: 10.432

Main menu

PWWP domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

blazegraph-runner