tumor suppressor candidate 3

Overview
Nametumor suppressor candidate 3 (AKG62134.1)
Smed IDSMED30004791
Length (bp)1794
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of tumor suppressor candidate 3 (SMED30004791) t-SNE clustered cells

Violin plots show distribution of expression levels for tumor suppressor candidate 3 (SMED30004791) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of tumor suppressor candidate 3 (SMED30004791) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for tumor suppressor candidate 3 (SMED30004791) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004791

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30004791h1SMcG0022597 dd_Smed_v4_2352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30004791h1SMcG0022597 dd_Smed_v4_2352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30004791h1SMcG0022597 dd_Smed_v4_2352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30004791h1SMcG0022597 dd_Smed_v4_2352_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
whole organismSMED30004791h1SMcG0022597 Contig51064newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30004791h1SMcG0022597 Contig51064uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Match: TUSC3 (tumor suppressor candidate 3 [Source:HGNC Symbol;Acc:HGNC:30242])

HSP 1 Score: 356.295 bits (913), Expect = 2.286e-118
Identity = 168/310 (54.19%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ ++K  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF+MVD+D+G DVF+ LN N+AP F+HFP KG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Match: TUSC3 (tumor suppressor candidate 3 [Source:HGNC Symbol;Acc:HGNC:30242])

HSP 1 Score: 356.295 bits (913), Expect = 3.098e-118
Identity = 168/310 (54.19%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ ++K  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF+MVD+D+G DVF+ LN N+AP F+HFP KG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Match: TUSC3 (tumor suppressor candidate 3 [Source:HGNC Symbol;Acc:HGNC:30242])

HSP 1 Score: 352.058 bits (902), Expect = 2.590e-117
Identity = 163/296 (55.07%), Postives = 226/296 (76.35%), Query Frame = 3 
Query:  114 DILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ++L +K+ QL++WS+R+++ R+N +KF+ ++K  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF+MVD+D+G DVF+ LN N+AP F+HFP KG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:    1 NLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 296
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Match: MAGT1 (magnesium transporter 1 [Source:HGNC Symbol;Acc:HGNC:28880])

HSP 1 Score: 347.051 bits (889), Expect = 5.875e-115
Identity = 157/313 (50.16%), Postives = 222/313 (70.93%), Query Frame = 3 
Query:   66 VLC-IFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ++C + SA+ Q   K E +L +K++QL++W+N++ VIR+N +KF+  VK  P+NYS+IVM TAL   RQC VCK A +EF I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+ D  ++   GF+AE +A+WI DR+D+ IRV RPPNY G ++L L +++   ++Y +R++++FL N+T W   +L  + +M SGQMWNHIRGPP  H NP TG + +I+ S   QFVAET IVLL    V+ G++++ EA+    D  KRK+  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   20 IVCDVPSASAQ--RKKEMVLSEKVSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSIFRSKYHGYPY 330
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Match: MAGT1 (magnesium transporter 1 [Source:HGNC Symbol;Acc:HGNC:28880])

HSP 1 Score: 347.436 bits (890), Expect = 1.486e-114
Identity = 157/313 (50.16%), Postives = 222/313 (70.93%), Query Frame = 3 
Query:   66 VLC-IFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ++C + SA+ Q   K E +L +K++QL++W+N++ VIR+N +KF+  VK  P+NYS+IVM TAL   RQC VCK A +EF I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+ D  ++   GF+AE +A+WI DR+D+ IRV RPPNY G ++L L +++   ++Y +R++++FL N+T W   +L  + +M SGQMWNHIRGPP  H NP TG + +I+ S   QFVAET IVLL    V+ G++++ EA+    D  KRK+  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   52 IVCDVPSASAQ--RKKEMVLSEKVSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSIFRSKYHGYPY 362
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Celegans
Match: ZK686.3 (Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [Source:UniProtKB/Swiss-Prot;Acc:P34669])

HSP 1 Score: 294.664 bits (753), Expect = 5.390e-95
Identity = 147/332 (44.28%), Postives = 209/332 (62.95%), Query Frame = 3 
Query:   66 VLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSR--LFFAMVDFDDGFDVFRMLNQNTAPVFIHF-PSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRK-----------------MFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            +L ++ +A Q        L  K+  L+D ++R+++++ N +K+KT V+  P+NYSMIVM TALSP  QC +CK A DEF IVANS RYT     R  +FF +VD++D   +F+ +N NTAP+  HF P  G+ K+ + MD  R GF A+ + +++ D++++ +RV RPPNYT  +++ALF++L   +LY KRNSLDFL NRT WG V L + F  MSGQMWNHIRGPP M  NP T +  FI+ S  FQ +AET+IV LLY  ++ G + +NEA+   S++  RK                   ++ GL     FFS  +S+FR KY+GYPY
Sbjct:    2 LLAVYESAQQ------QTLEDKVQNLVDLTSRQSIVKFNMDKWKTLVRMQPRNYSMIVMFTALSPGVQCPICKPAYDEFMIVANSHRYTSSEGDRRKVFFGIVDYEDAPQIFQQMNLNTAPILYHFGPKLGAKKRPEQMDFQRQGFDADAIGRFVADQTEVHVRVIRPPNYTAPVVIALFVALLLGMLYMKRNSLDFLFNRTVWGFVCLAITFIFMSGQMWNHIRGPPFMITNPNTKEPSFIHGSTQFQLIAETYIVGLLYALIAIGFICVNEAA-DQSNSKDRKNAGKKLNPLSLLNIPTNTLAIAGLVCICVFFSFLLSVFRSKYRGYPY 326
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Fly
Match: Ostgamma (gene:FBgn0032015 transcript:FBtr0079613)

HSP 1 Score: 334.339 bits (856), Expect = 2.474e-110
Identity = 155/328 (47.26%), Postives = 229/328 (69.82%), Query Frame = 3 
Query:   18 IKLFKNMLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ++L    L    L V +  I++AA Q  +K    L +K+  L+D + +K ++R N  KF+ YVK  P+NYSMIVMLTAL+P RQCQ+C+ A DEF+IVANS+R++   +++LFFAMVDFDDG +VF++L  NTAPVF+HFP+KG PK AD MD+ R GFAA+ +AK++ +R+DI IR+FRPPNY+GT+ +   ++L  + LY +RN+L+FL N+  WG +++   F+M+SGQMWNHIRGPP++H + Q G + +I+ S   Q V ET+IV+ L   +  G++++ E+       +K ++ ++ GL L   FFS  +S+FR K QGYPY
Sbjct:    1 MRLLHKTLLSGLLVVALFAIYAAA-QSKSKTGLSLSEKVQNLVDMNAKKPLLRFNGPKFREYVKSAPRNYSMIVMLTALAPSRQCQICRHAHDEFAIVANSYRFSSTYSNKLFFAMVDFDDGSEVFQLLRLNTAPVFMHFPAKGKPKGADTMDIHRVGFAADSIAKFVAERTDITIRIFRPPNYSGTVAMITLVALVGSFLYIRRNNLEFLYNKNLWGAIAVFFCFAMISGQMWNHIRGPPLVHKS-QNGGVAYIHGSSQGQLVVETYIVMFLNAMIVLGMILLIESG-TPKAHNKNRIMAMTGLVLLTVFFSFLLSVFRSKAQGYPY 325
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Match: magt1 (magnesium transporter 1 [Source:NCBI gene;Acc:324944])

HSP 1 Score: 358.992 bits (920), Expect = 6.782e-120
Identity = 162/323 (50.15%), Postives = 227/323 (70.28%), Query Frame = 3 
Query:   36 MLFRLYLYV-TVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ML +L + V  V+C+         K E +L +K++Q+++W +++AV+RLN EKFK  V+  P+NYS+IVM TAL PQRQC VC+ A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+AD  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L ++   ++ Y +RN+L+FL N+  W   +L  +  M SGQMWNHIRGPP  H NP TGQ+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G+ L V FFS  +S+FR KY GYPY
Sbjct:    1 MLHKLLIVVFLVVCLHDMRLNGQKKKETLLSEKVSQMMEWVSKRAVVRLNGEKFKRLVRAHPRNYSVIVMFTALQPQRQCGVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRADTYELQVRGFAAEQLARWVADRTDVHIRVIRPPNYAGPLMLGLLLAFIGSLAYLRRNNLEFLFNKNVWAFSALCFVLIMTSGQMWNHIRGPPYAHKNPNTGQVSYIHGSSQAQFVAETHIVLLFNAAVTIGMVLLHEAATSGLDIVKRKIMCVAGIGLVVLFFSWLLSVFRAKYHGYPY 323
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Match: tusc3 (tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-GENE-050522-381])

HSP 1 Score: 352.058 bits (902), Expect = 1.266e-117
Identity = 162/295 (54.92%), Postives = 228/295 (77.29%), Query Frame = 3 
Query:  117 ILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            +L +K+ Q+++WS+R++VIR+N +KF+ +VK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D+QIRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:    1 MLAEKVEQMMEWSSRRSVIRMNGDKFRRFVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTVVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADTFDLQRIGFASEQLAKWIADRTDVQIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 295
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Match: tusc3 (tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-GENE-050522-381])

HSP 1 Score: 352.058 bits (902), Expect = 1.266e-117
Identity = 162/295 (54.92%), Postives = 228/295 (77.29%), Query Frame = 3 
Query:  117 ILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            +L +K+ Q+++WS+R++VIR+N +KF+ +VK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D+QIRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:    1 MLAEKVEQMMEWSSRRSVIRMNGDKFRRFVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTVVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADTFDLQRIGFASEQLAKWIADRTDVQIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 295
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Match: tusc3 (tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-GENE-050522-381])

HSP 1 Score: 231.491 bits (589), Expect = 2.997e-72
Identity = 113/200 (56.50%), Postives = 150/200 (75.00%), Query Frame = 3 
Query:  402 LNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D+QIRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:    1 LNMNSAPTFMHFPAKGKPKRADTFDLQRIGFASEQLAKWIADRTDVQIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 200
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Match: magt1 (magnesium transporter 1 [Source:NCBI gene;Acc:324944])

HSP 1 Score: 176.407 bits (446), Expect = 2.290e-52
Identity = 75/131 (57.25%), Postives = 104/131 (79.39%), Query Frame = 3 
Query:  141 LIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRS 533
            +++W +++AV+RLN EKFK  V+  P+NYS+IVM TAL PQRQC VC+ A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+AD  ++   GFAAE +A+W+ DR+
Sbjct:    1 MMEWVSKRAVVRLNGEKFKRLVRAHPRNYSVIVMFTALQPQRQCGVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRADTYELQVRGFAAEQLARWVADRT 131
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Match: TUSC3 (tumor suppressor candidate 3 [Source:NCBI gene;Acc:100487046])

HSP 1 Score: 362.073 bits (928), Expect = 1.172e-120
Identity = 169/316 (53.48%), Postives = 237/316 (75.00%), Query Frame = 3 
Query:   54 LYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            L +  LC+ S   Q   K E++L +K+ Q+++WS+R++VIR+N +KF+ +VK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   24 LLILSLCLQSGGGQ--KKKENLLSEKVEQMMEWSSRRSVIRMNGDKFRRFVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTIVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 337
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Match: kif5a (kinesin family member 5A [Source:Xenbase;Acc:XB-GENE-983714])

HSP 1 Score: 355.14 bits (910), Expect = 3.360e-118
Identity = 156/312 (50.00%), Postives = 220/312 (70.51%), Query Frame = 3 
Query:   66 VLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            +L +     +   K E +L +K+ QL+DW++++ VIR+N +KF+  +K  P+NYS++VM TAL   RQC VCK A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FIHFP KG PKK D  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L +++   ++Y +R++LDFL N+T WG  +L  + +M SGQMWNHIRGPP  H NP T Q+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G++L V FFS  +S+FR KY GYPY
Sbjct:   13 LLALCGGLSEGQKKKEMVLSEKVGQLMDWASKRPVIRMNGDKFRRLIKSPPRNYSVVVMFTALQAHRQCVVCKQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFIHFPPKGKPKKGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNLDFLCNKTGWGLAALCFVLAMTSGQMWNHIRGPPYAHKNPHTNQVNYIHGSSQAQFVAETHIVLLFNGAVTLGMVLLHEAATSDLDVGKRKIMCIAGISLVVIFFSWLLSVFRSKYHGYPY 324
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Match: kif5a (kinesin family member 5A [Source:Xenbase;Acc:XB-GENE-983714])

HSP 1 Score: 337.421 bits (864), Expect = 2.516e-111
Identity = 148/289 (51.21%), Postives = 209/289 (72.32%), Query Frame = 3 
Query:  117 ILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIK 983
            +L +K+ QL+DW++++ VIR+N +KF+  +K  P+NYS++VM TAL   RQC VCK A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FIHFP KG PKK D  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L +++   ++Y +R++LDFL N+T WG  +L  + +M SGQMWNHIRGPP  H NP T Q+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G++L V FFS  +S+FR K
Sbjct:   21 VLSEKVGQLMDWASKRPVIRMNGDKFRRLIKSPPRNYSVVVMFTALQAHRQCVVCKQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFIHFPPKGKPKKGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNLDFLCNKTGWGLAALCFVLAMTSGQMWNHIRGPPYAHKNPHTNQVNYIHGSSQAQFVAETHIVLLFNGAVTLGMVLLHEAATSDLDVGKRKIMCIAGISLVVIFFSWLLSVFRSK 309
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Match: kif5a (kinesin family member 5A [Source:Xenbase;Acc:XB-GENE-983714])

HSP 1 Score: 337.035 bits (863), Expect = 3.871e-111
Identity = 148/289 (51.21%), Postives = 209/289 (72.32%), Query Frame = 3 
Query:  117 ILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIK 983
            +L +K+ QL+DW++++ VIR+N +KF+  +K  P+NYS++VM TAL   RQC VCK A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FIHFP KG PKK D  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L +++   ++Y +R++LDFL N+T WG  +L  + +M SGQMWNHIRGPP  H NP T Q+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G++L V FFS  +S+FR K
Sbjct:   29 VLSEKVGQLMDWASKRPVIRMNGDKFRRLIKSPPRNYSVVVMFTALQAHRQCVVCKQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFIHFPPKGKPKKGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNLDFLCNKTGWGLAALCFVLAMTSGQMWNHIRGPPYAHKNPHTNQVNYIHGSSQAQFVAETHIVLLFNGAVTLGMVLLHEAATSDLDVGKRKIMCIAGISLVVIFFSWLLSVFRSK 317
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Match: kif5a (kinesin family member 5A [Source:Xenbase;Acc:XB-GENE-983714])

HSP 1 Score: 337.421 bits (864), Expect = 4.362e-111
Identity = 148/289 (51.21%), Postives = 209/289 (72.32%), Query Frame = 3 
Query:  117 ILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIK 983
            +L +K+ QL+DW++++ VIR+N +KF+  +K  P+NYS++VM TAL   RQC VCK A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FIHFP KG PKK D  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L +++   ++Y +R++LDFL N+T WG  +L  + +M SGQMWNHIRGPP  H NP T Q+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G++L V FFS  +S+FR K
Sbjct:   40 VLSEKVGQLMDWASKRPVIRMNGDKFRRLIKSPPRNYSVVVMFTALQAHRQCVVCKQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFIHFPPKGKPKKGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNLDFLCNKTGWGLAALCFVLAMTSGQMWNHIRGPPYAHKNPHTNQVNYIHGSSQAQFVAETHIVLLFNGAVTLGMVLLHEAATSDLDVGKRKIMCIAGISLVVIFFSWLLSVFRSK 328
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Match: Tusc3 (tumor suppressor candidate 3 [Source:MGI Symbol;Acc:MGI:1933134])

HSP 1 Score: 358.992 bits (920), Expect = 1.487e-119
Identity = 170/310 (54.84%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ +VK  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF MVD+D+G DVF+ LN N+AP F+HFPSKG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFVKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFGMVDYDEGTDVFQQLNMNSAPTFMHFPSKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Match: Tusc3 (tumor suppressor candidate 3 [Source:MGI Symbol;Acc:MGI:1933134])

HSP 1 Score: 358.992 bits (920), Expect = 1.487e-119
Identity = 170/310 (54.84%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ +VK  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF MVD+D+G DVF+ LN N+AP F+HFPSKG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFVKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFGMVDYDEGTDVFQQLNMNSAPTFMHFPSKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Match: Magt1 (magnesium transporter 1 [Source:MGI Symbol;Acc:MGI:1914325])

HSP 1 Score: 348.591 bits (893), Expect = 1.203e-115
Identity = 153/299 (51.17%), Postives = 215/299 (71.91%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            K E +L +K++QL++W+N++ VIR+N +KF+  VK  P+NYS++VM TAL   RQC VCK A +EF I+ANSWRY++   +R+FFAMVDFD+G DVF+MLN N+AP FI+FP KG PK+AD  ++   GF+AE +A+WI DR+D+ IRV RPPNY G ++L L +++   ++Y +R++++FL N+T W   +L  + +M SGQMWNHIRGPP  H NP TG + +I+ S   QFVAET IVLL    V+ G++++ EA+    D  KR+M  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   32 KKEMVLSEKVSQLMEWANKRPVIRMNGDKFRRLVKAPPRNYSVVVMFTALQLHRQCVVCKQADEEFQILANSWRYSNAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPPKGKPKRADTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRRMMCIAGIGLVVLFFSWMLSIFRSKYHGYPY 330
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Match: Magt1 (magnesium transporter 1 [Source:MGI Symbol;Acc:MGI:1914325])

HSP 1 Score: 348.591 bits (893), Expect = 1.203e-115
Identity = 153/299 (51.17%), Postives = 215/299 (71.91%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            K E +L +K++QL++W+N++ VIR+N +KF+  VK  P+NYS++VM TAL   RQC VCK A +EF I+ANSWRY++   +R+FFAMVDFD+G DVF+MLN N+AP FI+FP KG PK+AD  ++   GF+AE +A+WI DR+D+ IRV RPPNY G ++L L +++   ++Y +R++++FL N+T W   +L  + +M SGQMWNHIRGPP  H NP TG + +I+ S   QFVAET IVLL    V+ G++++ EA+    D  KR+M  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   32 KKEMVLSEKVSQLMEWANKRPVIRMNGDKFRRLVKAPPRNYSVVVMFTALQLHRQCVVCKQADEEFQILANSWRYSNAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPPKGKPKRADTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRRMMCIAGIGLVVLFFSWMLSIFRSKYHGYPY 330
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Match: Magt1 (magnesium transporter 1 [Source:MGI Symbol;Acc:MGI:1914325])

HSP 1 Score: 348.591 bits (893), Expect = 3.322e-115
Identity = 153/299 (51.17%), Postives = 215/299 (71.91%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            K E +L +K++QL++W+N++ VIR+N +KF+  VK  P+NYS++VM TAL   RQC VCK A +EF I+ANSWRY++   +R+FFAMVDFD+G DVF+MLN N+AP FI+FP KG PK+AD  ++   GF+AE +A+WI DR+D+ IRV RPPNY G ++L L +++   ++Y +R++++FL N+T W   +L  + +M SGQMWNHIRGPP  H NP TG + +I+ S   QFVAET IVLL    V+ G++++ EA+    D  KR+M  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   65 KKEMVLSEKVSQLMEWANKRPVIRMNGDKFRRLVKAPPRNYSVVVMFTALQLHRQCVVCKQADEEFQILANSWRYSNAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPPKGKPKRADTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRRMMCIAGIGLVVLFFSWMLSIFRSKYHGYPY 363
[Close]
BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Match: sp|Q7ZV50|MAGT1_DANRE (Magnesium transporter protein 1 OS=Danio rerio OX=7955 GN=magt1 PE=1 SV=1)

HSP 1 Score: 358.992 bits (920), Expect = 5.120e-119
Identity = 162/323 (50.15%), Postives = 227/323 (70.28%), Query Frame = 3 
Query:   36 MLFRLYLYV-TVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ML +L + V  V+C+         K E +L +K++Q+++W +++AV+RLN EKFK  V+  P+NYS+IVM TAL PQRQC VC+ A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+AD  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L ++   ++ Y +RN+L+FL N+  W   +L  +  M SGQMWNHIRGPP  H NP TGQ+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G+ L V FFS  +S+FR KY GYPY
Sbjct:    1 MLHKLLIVVFLVVCLHDMRLNGQKKKETLLSEKVSQMMEWVSKRAVVRLNGEKFKRLVRAHPRNYSVIVMFTALQPQRQCGVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRADTYELQVRGFAAEQLARWVADRTDVHIRVIRPPNYAGPLMLGLLLAFIGSLAYLRRNNLEFLFNKNVWAFSALCFVLIMTSGQMWNHIRGPPYAHKNPNTGQVSYIHGSSQAQFVAETHIVLLFNAAVTIGMVLLHEAATSGLDIVKRKIMCVAGIGLVVLFFSWLLSVFRAKYHGYPY 323
[Close]
BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Match: sp|Q8BTV1|TUSC3_MOUSE (Tumor suppressor candidate 3 OS=Mus musculus OX=10090 GN=Tusc3 PE=1 SV=1)

HSP 1 Score: 358.992 bits (920), Expect = 1.040e-118
Identity = 170/310 (54.84%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ +VK  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF MVD+D+G DVF+ LN N+AP F+HFPSKG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFVKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFGMVDYDEGTDVFQQLNMNSAPTFMHFPSKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Match: sp|Q13454|TUSC3_HUMAN (Tumor suppressor candidate 3 OS=Homo sapiens OX=9606 GN=TUSC3 PE=1 SV=1)

HSP 1 Score: 356.295 bits (913), Expect = 1.488e-117
Identity = 168/310 (54.19%), Postives = 231/310 (74.52%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R+++ R+N +KF+ ++K  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF+MVD+D+G DVF+ LN N+AP F+HFP KG PK+AD  D+ R GFAAE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Match: sp|Q5ZJ06|MAGT1_CHICK (Magnesium transporter protein 1 OS=Gallus gallus OX=9031 GN=MAGT1 PE=2 SV=1)

HSP 1 Score: 350.903 bits (899), Expect = 7.650e-116
Identity = 154/306 (50.33%), Postives = 221/306 (72.22%), Query Frame = 3 
Query:   84 AADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            AA Q   + E +L +K++QL++W+++++VIR+N +KF+  VK  P+NYS+IVM TAL P RQC VCK A +E+ ++ANSWRY+    +++FFAMVDFD+G DVF+MLN N+AP FI+FP+KG PK+ D  ++   GFAAE +A+W+ DR+D+ IRV RPPNY G ++L L +++   ++Y + ++LDFL N+T W   +L  + +M SGQMWNHIRGPP  H NP TGQ+ +I+ S   QFVAET IVLL    V+ G+++++EA+    D  KRK+  + G+ L VFFFS  +S+FR KY GYPY
Sbjct:   20 AAGQ--KRKEMVLSEKVSQLMEWTSKRSVIRMNGDKFRRLVKAPPRNYSVIVMFTALQPHRQCVVCKQADEEYQVLANSWRYSSAFTNKIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRGSNLDFLYNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGQVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLHEAATSDMDVGKRKIMCIAGIGLVVFFFSWLLSVFRSKYHGYPY 323
[Close]
BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Match: sp|Q32L57|TUSC3_BOVIN (Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=2 SV=1)

HSP 1 Score: 350.132 bits (897), Expect = 3.194e-115
Identity = 166/310 (53.55%), Postives = 228/310 (73.55%), Query Frame = 3 
Query:   72 CIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            CI     Q   K E++L +K+ QL++WS+R++V R+N +KF+ ++K  P+NYSMIVM TAL PQRQC VC+ A++E+ I+ANSWRY+    ++LFF+ VD+D+G D+F+ LN N+AP F+HFP KG PK+AD  D+ R GF AE +AKWI DR+D+ IRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W  VSL ++F+M SGQMWNHIRGPP  H NP  GQ+ +I+ S   QFVAE+ I+L+L  A++ G+ ++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   35 CIQLGGGQ--KKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMDLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 342
[Close]
BLAST of tumor suppressor candidate 3 vs. TrEMBL
Match: A0A0F7CYH6 (Tumor suppressor candidate 3 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 667.537 bits (1721), Expect = 0.000e+0
Identity = 322/325 (99.08%), Postives = 322/325 (99.08%), Query Frame = 3 
Query:   30 KNMLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR 1004
            K   FRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR
Sbjct:   18 KICFFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR 342
[Close]
BLAST of tumor suppressor candidate 3 vs. TrEMBL
Match: A0A267E531 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig028467g1 PE=4 SV=1)

HSP 1 Score: 407.527 bits (1046), Expect = 1.441e-135
Identity = 185/319 (57.99%), Postives = 240/319 (75.24%), Query Frame = 3 
Query:   48 LYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTS-DASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
             YL + +     A DQ       +L +++ QLIDWS+RK+VIRLN++KF+ YV+G PKNYS+IVMLTALSP R CQVCK A +EF+IVANSWRY     S LFFAMVDFD+G DVF ML QN+APVFIHFP+KG PKK D MD+ R GF AEV+A+WI +R+DIQIRVFRPPNY+ T++L + MS+   VLY KR+SLDF+ N+ SWG  + T+IF+M+SGQMWNHIRGPP +H +P +   ++IYP  DFQF+AETFI+ ++Y A+   ++++NEA   +  DASKRK+ +L G+ +F  FFS  +SIFR KY GYPY
Sbjct:   10 FYLVIGITSADPAKDQ-------VLSQRVQQLIDWSSRKSVIRLNSDKFRQYVRGPPKNYSVIVMLTALSPSRGCQVCKYAHEEFTIVANSWRYAQSWTSSLFFAMVDFDEGSDVFSMLKQNSAPVFIHFPAKGQPKKGDVMDIHRIGFQAEVMARWITERTDIQIRVFRPPNYSWTLVLGILMSMAVGVLYLKRSSLDFIYNKKSWGICTTTIIFAMISGQMWNHIRGPPFLHKHPNSANFMYIYPGADFQFIAETFIIYIMYAAIVGSVVLLNEAHLSSKIDASKRKVIALSGIGIFAIFFSFLLSIFRSKYNGYPY 321
[Close]
BLAST of tumor suppressor candidate 3 vs. TrEMBL
Match: A0A267H3D2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig028467g3 PE=4 SV=1)

HSP 1 Score: 407.527 bits (1046), Expect = 1.538e-135
Identity = 185/319 (57.99%), Postives = 240/319 (75.24%), Query Frame = 3 
Query:   48 LYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTS-DASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
             YL + +     A DQ       +L +++ QLIDWS+RK+VIRLN++KF+ YV+G PKNYS+IVMLTALSP R CQVCK A +EF+IVANSWRY     S LFFAMVDFD+G DVF ML QN+APVFIHFP+KG PKK D MD+ R GF AEV+A+WI +R+DIQIRVFRPPNY+ T++L + MS+   VLY KR+SLDF+ N+ SWG  + T+IF+M+SGQMWNHIRGPP +H +P +   ++IYP  DFQF+AETFI+ ++Y A+   ++++NEA   +  DASKRK+ +L G+ +F  FFS  +SIFR KY GYPY
Sbjct:   10 FYLVIGITSADPAKDQ-------VLSQRVQQLIDWSSRKSVIRLNSDKFRQYVRGPPKNYSVIVMLTALSPSRGCQVCKYAHEEFTIVANSWRYAQSWTSSLFFAMVDFDEGSDVFSMLKQNSAPVFIHFPAKGQPKKGDVMDIHRIGFQAEVMARWITERTDIQIRVFRPPNYSWTLVLGILMSMAVGVLYLKRSSLDFIYNKKSWGICTTTIIFAMISGQMWNHIRGPPFLHKHPNSANFMYIYPGADFQFIAETFIIYIMYAAIVGSVVLLNEAHLSSKIDASKRKVIALSGIGIFAIFFSFLLSIFRSKYNGYPY 321
[Close]
BLAST of tumor suppressor candidate 3 vs. TrEMBL
Match: A0A267H1F0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig028467g2 PE=4 SV=1)

HSP 1 Score: 407.527 bits (1046), Expect = 1.624e-135
Identity = 180/299 (60.20%), Postives = 234/299 (78.26%), Query Frame = 3 
Query:  108 NEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTS-DASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
             + +L +++ QLIDWS+RK+VIRLN++KF+ YV+G PKNYS+IVMLTALSP R CQVCK A +EF+IVANSWRY     S LFFAMVDFD+G DVF ML QN+APVFIHFP+KG PKK D MD+ R GF AEV+A+WI +R+DIQIRVFRPPNY+ T++L + MS+   VLY KR+SLDF+ N+ SWG  + T+IF+M+SGQMWNHIRGPP +H +P +   ++IYP  DFQF+AETFI+ ++Y A+   ++++NEA   +  DASKRK+ +L G+ +F  FFS  +SIFR KY GYPY
Sbjct:   23 KDQVLSQRVQQLIDWSSRKSVIRLNSDKFRQYVRGPPKNYSVIVMLTALSPSRGCQVCKYAHEEFTIVANSWRYAQSWTSSLFFAMVDFDEGSDVFSMLKQNSAPVFIHFPAKGQPKKGDIMDIHRVGFQAEVMARWITERTDIQIRVFRPPNYSWTLVLGILMSMAVGVLYLKRSSLDFIYNKKSWGICTTTIIFAMISGQMWNHIRGPPFLHKHPNSANFMYIYPGADFQFIAETFIIYIMYAAIVGSVVLLNEAHLSSKIDASKRKVIALSGIGIFAIFFSFLLSIFRSKYNGYPY 321
[Close]
BLAST of tumor suppressor candidate 3 vs. TrEMBL
Match: A0A2C9K2H9 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106078783 PE=4 SV=1)

HSP 1 Score: 399.438 bits (1025), Expect = 2.286e-132
Identity = 177/316 (56.01%), Postives = 242/316 (76.58%), Query Frame = 3 
Query:   54 LYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            ++++    F      + K E+ LG K+ QL++W+N+K++IRLN +KF+ YVK +P+NYS+IVMLTAL PQR C VCK A+DEF I+ANSWRY+   ++RLFFA+VD+D+G DVF+ +   TAPVF+HFP KG  KKAD  D++R+G+AAE++AKW+ +R+DIQIRVFRPPNY+GT++LAL  ++   +LYFKRN+L+FL N+TSWG +SL +IF+M SGQMWNHIRGPP+MH NP TGQ+ +I+ S   QF+ ET+IV+LL  AV  G +M+NEA  +  D  K+++ SL GL     FFSL +S+FR KYQGYPY
Sbjct:    1 MHISQXXXFLLVSADVRKKEESLGDKVQQLMEWNNKKSIIRLNGDKFRQYVKASPRNYSVIVMLTALQPQRSCVVCKHANDEFQILANSWRYSQQYSNRLFFALVDYDEGSDVFQSMKLTTAPVFMHFPPKGKQKKADTHDINRNGYAAEMLAKWVGERTDIQIRVFRPPNYSGTVILALLFAMIGGLLYFKRNNLEFLYNKTSWGIISLAIIFAMTSGQMWNHIRGPPVMHRNPNTGQMHYIHGSSQGQFIMETYIVMLLNTAVVVGFIMLNEAQTMKGDPGKKRILSLVGLGCVTIFFSLLLSVFRSKYQGYPY 316
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Cavefish
Match: magt1 (magnesium transporter 1 [Source:NCBI gene;Acc:324944])

HSP 1 Score: 348.977 bits (894), Expect = 4.137e-116
Identity = 159/300 (53.00%), Postives = 220/300 (73.33%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR 1004
            K E ++ +K+ Q++DW++++AVIRLN EKF+ +V+  P+NYS+I+M TAL PQRQC VC+ A +E+ I+ANSWRY+    +R+FFAMVDFD+G DVF+MLN N+AP FI+FPSKG PK+AD  ++   GFAAE +A+WI DR+D+ IRV RPPNY G ++L L ++L  ++ Y +RN+L+FL N+  W   +L  +  M SGQMWNHIRGPP  H NP TGQ+ +I+ S   QFVAET IVLL   AV+ G+++++EA+    D  KRK+  + G+ L + FFS  +SIFR KY GYPYR
Sbjct:   25 KKETLVSEKVGQMMDWASKRAVIRLNGEKFRRFVRAPPRNYSVIIMFTALQPQRQCAVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPSKGKPKRADTYELQVRGFAAEQLARWIADRTDVHIRVIRPPNYAGPLMLGLLLALIGSLAYLRRNNLEFLYNKNVWAFSALCFVLIMTSGQMWNHIRGPPYAHKNPSTGQVSYIHGSSQAQFVAETHIVLLFNAAVTLGMVLLHEAATSDMDIGKRKIMCVAGIGLVMLFFSWLLSIFRAKYHGYPYR 324
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Cavefish
Match: tusc3 (tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-GENE-050522-381])

HSP 1 Score: 265.774 bits (678), Expect = 4.428e-84
Identity = 122/279 (43.73%), Postives = 184/279 (65.95%), Query Frame = 3 
Query:  114 DILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFF 950
            ++L +K+ Q+++WS+R++VIR+N +KF+ +VK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D                               R++L+ ++   S    +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR+         F+F+
Sbjct:   43 NMLVEKVEQMMEWSSRRSVIRMNGDKFRRFVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTVVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADTFDLQRIGFASEQLAKWIADRTDQTT----------------------------RDTLETIQQLHSNYLGTLCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRSKFCCSFHNFLFY 293
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Yeast
Match: OST3 (Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins [Source:SGD;Acc:S000005611])

HSP 1 Score: 72.4034 bits (176), Expect = 3.231e-14
Identity = 81/322 (25.16%), Postives = 148/322 (45.96%), Query Frame = 3 
Query:  138 QLIDWSNR--KAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHL------RNSRLFFAMVDFDD-------GFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRS-GFAAEVVAKWIQDRSDI-QIRVFR---PPNYTGTMLLALFMSLGATVLYFKRNS---LDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSG-DFQFVAETFIVLLLYIAVSAGLLMMNEA-SFVTSD---ASKRKMF------SLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            +L+  +N+  K +I L    F+  +    +N  ++ + TA +P+  C +C     E+  +  SW   H        ++ +FF  V+ +D        F  F++   N   +FI  P   SP   D+  +S S    +E + + IQ      Q+  F    P ++T  +     +    TVL FK+ S      + +R  W T+S   I  M+S  M+N IR   +    P+ G++++  P+    QF  ET +++L+Y  ++A ++++ +   F+ S     +K+  F      S   L ++VFF +LT ++F IK   YP+
Sbjct:   27 RLLKLANKSPKKIIPLKDSSFENILAPPHENAYIVALFTATAPEIGCSLCLELESEYDTIVASWFDDHPDAKSSNSDTSIFFTKVNLEDPSKTIPKAFQFFQL--NNVPRLFIFKP--NSPSILDHSVISISTDTGSERMKQIIQAIKQFSQVNDFSLHLPMDWTPIITST--IITFITVLLFKKQSKLMFSIISSRIIWATLSTFFIICMISAYMFNQIRNTQLAGVGPK-GEVMYFLPNEFQHQFAIETQVMVLIYGTLAALVVVLVKGIQFLRSHLYPETKKAYFIDAILASFCALFIYVFFAALT-TVFTIKSPAYPF 340
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Yeast
Match: OST6 (Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p [Source:SGD;Acc:S000004481])

HSP 1 Score: 49.6766 bits (117), Expect = 5.695e-7
Identity = 63/313 (20.13%), Postives = 129/313 (41.21%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSM--IVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSD--------IQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWG----TVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVF-FFSLTISIFRIKYQGYP 998
            K+       +  ++   +   VI +  + +    +G P  +++  I M    S    CQ+C      +  VA+  R    ++  LFF  VD ++   + + L     P  + +P   S K++ +   +   +   +V +  ++           + I +  P  +     +  F++     ++ K+  L  + N+  W      +SL ++   ++G  +  +   P +  + +   + F   SG +QF  E F V L+YI +SA  +++     ++  + K +      LA  +F FFS  IS + IK  GYP
Sbjct:   21 KSTATASHNIDDILQLKDDTGVITVTADNYPLLSRGVPGYFNILYITMRGTNSNGMSCQLCHDFEKTYHAVADVIRSQAPQSLNLFFT-VDVNEVPQLVKDLKLQNVPHLVVYPPAESNKQSQFEWKTSPFYQYSLVPENAENTLQFGDFLAKILNISITVPQAFNVQEFVYYFVACMVVFIFIKKVILPKVTNK--WKLFSMILSLGILLPSITGYKFVEMNAIPFIARDAKNRIMYFSGGSG-WQFGIEIFSVSLMYIVMSALSVLLIYVPKISCVSEKMRGLLSSFLACVLFYFFSYFISCYLIKNPGYP 329
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Nematostella
Match: EDO40810 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S666])

HSP 1 Score: 294.278 bits (752), Expect = 1.495e-96
Identity = 129/233 (55.36%), Postives = 180/233 (77.25%), Query Frame = 3 
Query:  144 IDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYI 842
            ++W++RK++IRLN +K++TY++ +P+NYS+I+MLTAL+P RQC +C+ A +E+ I+ANSWRY+    +RLFFAMVDFD+G DVF  L  N+APVF+HFP KG PKK D  D+ R GF+AE +A+W+ +R+D+Q+RVFRPPNY G + L L + L   +LY +R +L+FL N++ W   +L ++F+M SGQMWNHIRGPP  H NPQTGQ+ +I+ S   QFVAET IV+LL I
Sbjct:    1 MEWNHRKSIIRLNGDKYRTYLRASPRNYSVILMLTALAPHRQCAICREAHNEYLIIANSWRYSQQYTNRLFFAMVDFDEGPDVFNALRLNSAPVFMHFPPKGKPKKGDTYDMQRMGFSAEQIARWVGERTDVQVRVFRPPNYMGAIALGLLVVLIGGLLYIRRKNLEFLYNKSYWAMGALCVVFAMTSGQMWNHIRGPPYAHRNPQTGQVSYIHGSSQAQFVAETHIVILLSI 233
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Medaka
Match: tusc3 (tumor suppressor candidate 3 [Source:NCBI gene;Acc:101168184])

HSP 1 Score: 358.992 bits (920), Expect = 7.578e-120
Identity = 165/299 (55.18%), Postives = 231/299 (77.26%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            K E++L +K+ Q+++WS+R++VIR+N +KF+ YVK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D+QIRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR++  L GL L VFFFS  +SIFR KY GYPY
Sbjct:   33 KKENLLSEKVDQMMEWSSRRSVIRMNGDKFRRYVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTVVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADSFDLQRIGFASEQLAKWIADRTDVQIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 331
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BLAST of tumor suppressor candidate 3 vs. Ensembl Medaka
Match: magt1 (magnesium transporter protein 1 [Source:NCBI gene;Acc:101174815])

HSP 1 Score: 345.125 bits (884), Expect = 1.738e-114
Identity = 150/299 (50.17%), Postives = 215/299 (71.91%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPY 1001
            K E ++ +K++Q+++W+++++VIR+N +KF+ +VK  P+NYSM++M TAL P RQC VC+ A +EF ++ANSWRY+    +++FFA VDFD+G DVF+M+N N+AP FIHFP KG P+K+D  ++   GFAAE +A+W+ DR+D+QIR+ RPPNY G +LL   +++   + Y +RN+L+FL ++  W   +L     M SGQMWNHIRGPP  H NP TGQ+ +I+ S   QFVAET IVLL   AV+AG++++ EA+    D  KRKM  + G+ L V FFS  +SIFR KY GYPY
Sbjct:   25 KKETLVSEKVSQMMEWASKRSVIRMNGDKFRRFVKAPPRNYSMVIMFTALQPHRQCGVCRQADEEFQVLANSWRYSSAFTNKVFFASVDFDEGSDVFQMMNMNSAPTFIHFPYKGKPRKSDTYELQVRGFAAEQLARWVADRTDVQIRIIRPPNYAGPLLLGFMLAVIGGLAYLRRNNLEFLFSKNVWAFSALCFTLIMTSGQMWNHIRGPPYAHKNPSTGQVSYIHGSSQAQFVAETHIVLLFNGAVTAGMVLLCEAATGDMDVGKRKMTCVAGIFLVVVFFSWLLSIFRAKYHGYPY 323
[Close]
BLAST of tumor suppressor candidate 3 vs. Ensembl Medaka
Match: tusc3 (tumor suppressor candidate 3 [Source:NCBI gene;Acc:101168184])

HSP 1 Score: 338.576 bits (867), Expect = 5.047e-112
Identity = 146/269 (54.28%), Postives = 210/269 (78.07%), Query Frame = 3 
Query:  105 KNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRK 911
            K E++L +K+ Q+++WS+R++VIR+N +KF+ YVK  P+NYS+IVM TAL PQRQC VC+ A++E+ ++ANSWRY+   +++LFF +VD+D+G DVF+ LN N+AP F+HFP+KG PK+AD  D+ R GFA+E +AKWI DR+D+QIRVFRPPNY+GT+ LAL +SL   +LY +RN+L+F+ N+T W   +L ++F+M SGQMWNHIRGPP  H NPQ GQ+ +I+ S   QFVAE+ I+LLL  A++ G++++NEA+    D  KR+
Sbjct:   33 KKENLLSEKVDQMMEWSSRRSVIRMNGDKFRRYVKAPPRNYSVIVMFTALQPQRQCSVCRQANEEYQVLANSWRYSSAFSNKLFFTVVDYDEGADVFQQLNMNSAPTFMHFPAKGKPKRADSFDLQRIGFASEQLAKWIADRTDVQIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMAALCVVFAMTSGQMWNHIRGPPYAHKNPQNGQVSYIHGSSQAQFVAESHIILLLNAAITMGMVLLNEAATSKGDVGKRR 301
[Close]
BLAST of tumor suppressor candidate 3 vs. Planmine SMEST
Match: SMESG000016218.1 (SMESG000016218.1)

HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0
Identity = 322/323 (99.69%), Postives = 323/323 (100.00%), Query Frame = 3 
Query:   36 MLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR 1004
            MLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFP+KGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR
Sbjct:    1 MLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPAKGSPKKADYMDVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLALFVFFFSLTISIFRIKYQGYPYR 323
[Close]
BLAST of tumor suppressor candidate 3 vs. Planmine SMEST
Match: SMESG000000720.1 (SMESG000000720.1)

HSP 1 Score: 101.679 bits (252), Expect = 2.259e-23
Identity = 84/323 (26.01%), Postives = 148/323 (45.82%), Query Frame = 3 
Query:   66 VLCIFSAADQPLNKNEDILGKKLTQLIDW----SNRKAVIRLNTEKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTHLRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYM---DVSRSGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRNSLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIYPSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMF---SLGGLALFVFFFSLTISIFRIKYQGYPYR 1004
            ++ I ++    +N  + I  KKL Q I +    +N   VI +   +F  ++   P+N+S+++  T ++  ++CQ C    + F  +A S+R T  +N+ L+F  +DFD    VF      + P F+ F  +G  +  DY     V R    AE +AK ++  + I+I +          ++ +F  +   +L + +     + NR  W  +S   I    SGQM+N+I        + +      I  S   Q++AET IV  LY+  +  ++ +   S +     K K+F     G + L +   SL + I+R K   YPYR
Sbjct:    7 IVTIITSLIFTINAAKTISIKKLMQNIYFFKSHTNLNPVIFMEETQFTKHIIQMPRNFSIVIEFTMVNSDKRCQYCNKFHESFKTLAFSYRVT--KNNELYFVTIDFDKAQRVFETFQIKSVPQFLVFGKQGRTR--DYRLLPPVLR--LDAETLAKNVRHVTGIKIHIIDQSTNILKYIILMFGFICLCLLQYDK-FYKVISNRKFWAILSTMFIIISSSGQMYNYINYRSFAKRSFELSMENLISKSS--QYIAETIIVCFLYVGSTFCIITLYSISKIALTNPKLKLFLEIIFGTMLLII--VSLLVKIYRFKNSFYPYR 318
The following BLAST results are available for this feature:
BLAST of tumor suppressor candidate 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TUSC32.286e-11854.19tumor suppressor candidate 3 [Source:HGNC Symbol;A... [more]
TUSC33.098e-11854.19tumor suppressor candidate 3 [Source:HGNC Symbol;A... [more]
TUSC32.590e-11755.07tumor suppressor candidate 3 [Source:HGNC Symbol;A... [more]
MAGT15.875e-11550.16magnesium transporter 1 [Source:HGNC Symbol;Acc:HG... [more]
MAGT11.486e-11450.16magnesium transporter 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ZK686.35.390e-9544.28Probable dolichyl-diphosphooligosaccharide--protei... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Ostgamma2.474e-11047.26gene:FBgn0032015 transcript:FBtr0079613[more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
magt16.782e-12050.15magnesium transporter 1 [Source:NCBI gene;Acc:3249... [more]
tusc31.266e-11754.92tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-... [more]
tusc31.266e-11754.92tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-... [more]
tusc32.997e-7256.50tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-... [more]
magt12.290e-5257.25magnesium transporter 1 [Source:NCBI gene;Acc:3249... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TUSC31.172e-12053.48tumor suppressor candidate 3 [Source:NCBI gene;Acc... [more]
kif5a3.360e-11850.00kinesin family member 5A [Source:Xenbase;Acc:XB-GE... [more]
kif5a2.516e-11151.21kinesin family member 5A [Source:Xenbase;Acc:XB-GE... [more]
kif5a3.871e-11151.21kinesin family member 5A [Source:Xenbase;Acc:XB-GE... [more]
kif5a4.362e-11151.21kinesin family member 5A [Source:Xenbase;Acc:XB-GE... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tusc31.487e-11954.84tumor suppressor candidate 3 [Source:MGI Symbol;Ac... [more]
Tusc31.487e-11954.84tumor suppressor candidate 3 [Source:MGI Symbol;Ac... [more]
Magt11.203e-11551.17magnesium transporter 1 [Source:MGI Symbol;Acc:MGI... [more]
Magt11.203e-11551.17magnesium transporter 1 [Source:MGI Symbol;Acc:MGI... [more]
Magt13.322e-11551.17magnesium transporter 1 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of tumor suppressor candidate 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q7ZV50|MAGT1_DANRE5.120e-11950.15Magnesium transporter protein 1 OS=Danio rerio OX=... [more]
sp|Q8BTV1|TUSC3_MOUSE1.040e-11854.84Tumor suppressor candidate 3 OS=Mus musculus OX=10... [more]
sp|Q13454|TUSC3_HUMAN1.488e-11754.19Tumor suppressor candidate 3 OS=Homo sapiens OX=96... [more]
sp|Q5ZJ06|MAGT1_CHICK7.650e-11650.33Magnesium transporter protein 1 OS=Gallus gallus O... [more]
sp|Q32L57|TUSC3_BOVIN3.194e-11553.55Tumor suppressor candidate 3 OS=Bos taurus OX=9913... [more]
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BLAST of tumor suppressor candidate 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0F7CYH60.000e+099.08Tumor suppressor candidate 3 (Fragment) OS=Schmidt... [more]
A0A267E5311.441e-13557.99Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267H3D21.538e-13557.99Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267H1F01.624e-13560.20Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A2C9K2H92.286e-13256.01Uncharacterized protein OS=Biomphalaria glabrata O... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
magt14.137e-11653.00magnesium transporter 1 [Source:NCBI gene;Acc:3249... [more]
tusc34.428e-8443.73tumor suppressor candidate 3 [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tumor suppressor candidate 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
OST33.231e-1425.16Gamma subunit of the oligosaccharyltransferase com... [more]
OST65.695e-720.13Subunit of the oligosaccharyltransferase complex o... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO408101.495e-9655.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of tumor suppressor candidate 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tusc37.578e-12055.18tumor suppressor candidate 3 [Source:NCBI gene;Acc... [more]
magt11.738e-11450.17magnesium transporter protein 1 [Source:NCBI gene;... [more]
tusc35.047e-11254.28tumor suppressor candidate 3 [Source:NCBI gene;Acc... [more]
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BLAST of tumor suppressor candidate 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000016218.10.000e+099.69SMESG000016218.1[more]
SMESG000000720.12.259e-2326.01SMESG000000720.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30004791
GenBankAKG62134.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004791 ID=SMED30004791|Name=tumor suppressor candidate 3|organism=Schmidtea mediterranea sexual|type=transcript|length=1794bp
CTTTGACATACGTTTAAATCAAATTATTCAAAAATATGCTTTTTCGATTA
TACCTATATGTGACAGTTCTTTGCATATTTTCAGCTGCTGATCAACCCTT
AAATAAAAATGAAGATATTTTGGGTAAGAAATTAACACAGTTAATCGATT
GGTCTAATCGAAAAGCAGTTATTCGATTAAATACTGAAAAGTTTAAAACG
TATGTCAAAGGTACACCAAAGAATTATTCAATGATAGTCATGCTTACCGC
ATTATCGCCACAGCGTCAATGTCAAGTTTGCAAAGCGGCTAGTGATGAAT
TTTCAATTGTTGCCAATTCTTGGCGATATACGCATTTACGAAATTCACGT
TTATTTTTTGCTATGGTGGATTTCGATGACGGATTTGACGTGTTTAGAAT
GTTAAATCAAAACACAGCTCCTGTTTTTATCCATTTCCCCTCTAAGGGAA
GCCCTAAAAAAGCTGATTATATGGATGTGAGTCGGAGTGGATTCGCTGCT
GAAGTGGTTGCAAAATGGATTCAAGATCGGTCAGATATTCAGATCAGAGT
ATTCCGACCACCCAATTACACCGGAACCATGCTGCTGGCACTGTTTATGT
CCCTCGGTGCTACAGTCCTCTATTTTAAACGCAACAGTCTCGATTTTTTG
AAAAATCGGACTTCATGGGGCACAGTTTCATTGACTCTCATTTTCTCAAT
GATGTCAGGCCAGATGTGGAATCACATTCGGGGCCCTCCAATGATGCACG
CCAATCCCCAGACGGGCCAACTCGTATTCATTTATCCCAGTGGAGATTTC
CAGTTCGTTGCGGAAACATTTATCGTGTTGCTATTGTATATCGCGGTCTC
GGCGGGCTTGCTGATGATGAATGAGGCGAGTTTTGTGACATCAGATGCCA
GCAAGAGGAAAATGTTTTCATTGGGCGGCTTAGCGCTGTTCGTATTTTTC
TTTAGCTTGACAATCTCGATATTCCGCATCAAATATCAAGGCTATCCGTA
CCGGCTGCTGTTCTAGCGGTTGCCTTGGTAACTGTCTCTTTGCTGTGGCA
ATCGATCGGCTGCCGTTGCTATCGATTATTGTTGTTTTGTAGAATGAATA
TATTGTCCTTGTTGTTTTCATTTGCGCTTGAAAATTATTATCGATTATTT
GCTCGCTCGATCTGATTGGCTATTTGTGTCCATATTAATTTGTTGCAATG
GAACTGCTGGCTGATGTTTGACTGGGATTTCCACCAATTGTGAATTATAT
AAGTTATCGTTGTCAGTTGCGGTCAATCCTTATCGCATTTCCAGTGATAA
TATATCGGTTGTCGTGGAGATTACGGTGATTGCACTTGTGATATTTGGGG
CTATCTCGAACAATCTAATGATTGGATTTCAGCGGAATAATTCTAGTTTA
TTTGGTAGAAGTTTTCGCTTCTATATATTTGAAAGAATTTGTTAGGAAAA
TATTGTAATTTGGAATTAGTGCAAATTGTACAATATTATATTGGTATTTG
TGCCGGGCAGTCAGAATTCTACATTTCCCAATTGTTAATATTTGCGTTGT
GATTGCTGGTGCTCTGAGATAATATATTTATTTCAATAATTTTGGCAAAT
GAAAACCATGCGCATTAATTACTGGTTAAATAGTTTTATTTACAATTATA
TTTTGTTTTGTTACAATTTGATGATTTTATCGGAATTAACTGATCCATAG
CAATGGGTCCTAGCAGTTAGCACTGTGTTTTGCTGGAGCCGCTGCGCTAC
CGTCATATTAATATTTGCACAATCTAGTTGGTATTTGTGATCAG
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protein sequence of SMED30004791-orf-1

>SMED30004791-orf-1 ID=SMED30004791-orf-1|Name=SMED30004791-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=327bp
MLFRLYLYVTVLCIFSAADQPLNKNEDILGKKLTQLIDWSNRKAVIRLNT
EKFKTYVKGTPKNYSMIVMLTALSPQRQCQVCKAASDEFSIVANSWRYTH
LRNSRLFFAMVDFDDGFDVFRMLNQNTAPVFIHFPSKGSPKKADYMDVSR
SGFAAEVVAKWIQDRSDIQIRVFRPPNYTGTMLLALFMSLGATVLYFKRN
SLDFLKNRTSWGTVSLTLIFSMMSGQMWNHIRGPPMMHANPQTGQLVFIY
PSGDFQFVAETFIVLLLYIAVSAGLLMMNEASFVTSDASKRKMFSLGGLA
LFVFFFSLTISIFRIKYQGYPYRLLF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000136whole organism
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036249Thioredoxin-like_sf
IPR012336Thioredoxin-like_fold
IPR021149OligosaccharylTrfase_OST3/OST6
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036249Thioredoxin-like superfamilyGENE3DG3DSA:3.40.30.10coord: 29..183
e-value: 4.3E-41
score: 142.5
IPR036249Thioredoxin-like superfamilySUPERFAMILYSSF52833Thioredoxin-likecoord: 38..164
IPR021149Oligosaccharyl transferase complex, subunit OST3/OST6PFAMPF04756OST3_OST6coord: 35..322
e-value: 1.2E-98
score: 330.1
IPR021149Oligosaccharyl transferase complex, subunit OST3/OST6PANTHERPTHR12692DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATEDcoord: 3..325
NoneNo IPR availablePANTHERPTHR12692:SF1TUMOR SUPPRESSOR CANDIDATE 3coord: 3..325
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.662
NoneNo IPR availableTMHMMTMhelixcoord: 293..315
NoneNo IPR availableTMHMMTMhelixcoord: 255..277
NoneNo IPR availableTMHMMTMhelixcoord: 178..197
NoneNo IPR availableTMHMMTMhelixcoord: 210..228