RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30004755
Length (bp)	2749

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30004755) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30004755) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30004755) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30004755) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30004755

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30004755	SMESG000015738.1	SmedASXL_016047	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
head region	SMED30004755	SMESG000015738.1	SmedASXL_016048	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30004755	SMESG000015738.1	dd_Smed_v4_14782_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30004755	SMESG000015738.1	dd_Smed_v4_14782_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30004755	SMESG000015738.1	dd_Smed_v6_14782_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 61.6178 bits (148), Expect = 7.378e-11
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 61.6178 bits (148), Expect = 7.449e-11
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 63.1586 bits (152), Expect = 9.417e-11
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 62.3882 bits (150), Expect = 1.120e-10
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 65.4698 bits (158), Expect = 1.411e-10
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 79.337 bits (194), Expect = 9.586e-15
Identity = 60/215 (27.91%), Postives = 100/215 (46.51%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKT----EKIDQL--------CPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEI 712
            +E LLTC +CL +Y  P++LPCQHTFC  PCLE   D   R +KCP CR  H      + +   N+T+   +++ +  T     +I++         C +C+   +D   C  C +  CK C + H++  K ++  L N +K+  +   E    L   +  M    +    EI + F+     LK+++   L  V T        + +L + +EI
Sbjct:   37 IEQLLTCPICLDRYKQPKLLPCQHTFCY-PCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEYIHRYNLERCKICDEK-ADCEPCAHCDRKACKECRQTHMDMLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLMEVDTFQATETRNMSNLRDVLEI 249

HSP 2 Score: 55.4546 bits (132), Expect = 2.008e-7
Identity = 25/51 (49.02%), Postives = 36/51 (70.59%), Query Frame = 2

Query: 1145 SIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            S++    + + +FG +G   G+F +PRGIAIDS  N +IIADS N+R+QVF
Sbjct:  878 SVFDPHGVHLFSFGEEGFHGGQFKFPRGIAIDSQEN-LIIADSGNNRIQVF 927

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 78.9518 bits (193), Expect = 1.007e-14
Identity = 60/215 (27.91%), Postives = 100/215 (46.51%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKT----EKIDQL--------CPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEI 712
            +E LLTC +CL +Y  P++LPCQHTFC  PCLE   D   R +KCP CR  H      + +   N+T+   +++ +  T     +I++         C +C+   +D   C  C +  CK C + H++  K ++  L N +K+  +   E    L   +  M    +    EI + F+     LK+++   L  V T        + +L + +EI
Sbjct:   37 IEQLLTCPICLDRYKQPKLLPCQHTFCY-PCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEYIHRYNLERCKICDEK-ADCEPCAHCDRKACKECRQTHMDMLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLMEVDTFQATETRNMSNLRDVLEI 249

HSP 2 Score: 55.4546 bits (132), Expect = 2.045e-7
Identity = 25/51 (49.02%), Postives = 36/51 (70.59%), Query Frame = 2

Query: 1145 SIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            S++    + + +FG +G   G+F +PRGIAIDS  N +IIADS N+R+QVF
Sbjct:  828 SVFDPHGVHLFSFGEEGFHGGQFKFPRGIAIDSQEN-LIIADSGNNRIQVF 877

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-3 (NHL (Ring finger b-box coiled coil) domain containing [Source:UniProtKB/TrEMBL;Acc:H2L0K3])

HSP 1 Score: 55.4546 bits (132), Expect = 1.566e-7
Identity = 57/234 (24.36%), Postives = 103/234 (44.02%), Query Frame = 2

Query:  101 FMEDLLTCSVCLRKYDD----PRVLPCQHTFCLKPCLEKLFDVNFRQ----IKCPLCRFVHCFAKGYITSLPKNFTIRSIMD-MSIDKTEKI--------DQL--CPLCNALISD-----------LXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEI 712
            F E  LTCS CL  YD     P++LPC H+ CL  C+ +L +++       ++CPLCR V     G +   P  F I  ++D M I + + +        DQL  C  C+ +  +                       K   +I + + K  L+AL ++   T++ E          I  ++    K++ +IN +  ++  +++ R+  L++ VR +   R    K L++ +E+
Sbjct:   18 FSETFLTCSTCLYTYDGNTRKPKLLPCSHSVCLF-CVTQLAELSPETQPPTLRCPLCREVCPIPAGGVILFPAAFFINQLLDVMQIQRKDVVPSCSNHPTDQLLYCETCDLVFCENCQDSVVNKKCDEHTVVPLSIAIKRMSEIVVYRAKGRLRAL-DDAHVTVNRE----------IVQLDGNVDKIVEQINAAIQEVSNLVENRRRVLIETVRVR---RDEKRKVLKDQLEV 236

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: lin-41 (pep chromosome:WBcel235:I:9335965:9342443:-1 gene:WBGene00003026.1 transcript:C12C8.3b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-41)

HSP 1 Score: 54.6842 bits (130), Expect = 3.255e-7
Identity = 24/43 (55.81%), Postives = 31/43 (72.09%), Query Frame = 2

Query: 1169 PILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            PILTFG +G+G GE   P GI +D    R+I+AD SN+RVQ+F
Sbjct:  827 PILTFGKEGSGDGELCRPWGICVDQR-GRVIVADRSNNRVQIF 868

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: lin-41 (pep chromosome:WBcel235:I:9334812:9342496:-1 gene:WBGene00003026.1 transcript:C12C8.3b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-41)

HSP 1 Score: 54.6842 bits (130), Expect = 3.255e-7
Identity = 24/43 (55.81%), Postives = 31/43 (72.09%), Query Frame = 2

Query: 1169 PILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            PILTFG +G+G GE   P GI +D    R+I+AD SN+RVQ+F
Sbjct:  827 PILTFGKEGSGDGELCRPWGICVDQR-GRVIVADRSNNRVQIF 868

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: tn (gene:FBgn0265356 transcript:FBtr0114622)

HSP 1 Score: 87.8113 bits (216), Expect = 3.688e-17
Identity = 35/82 (42.68%), Postives = 53/82 (64.63%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
             E LLTC VCL +Y  P++LPCQH+FC++PC+E L D   RQ+KCP CR  H      + + P N T++  +++ I+ T ++
Sbjct:    4 FEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGEL 85

HSP 2 Score: 59.6918 bits (143), Expect = 1.459e-8
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 2

Query: 1142 QSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            + +Y+ K   +   G +G+  G F WPRG+A+    N I++ADSSNHRVQVF
Sbjct: 1232 KQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAV-GPDNSIVVADSSNHRVQVF 1282

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: tn (gene:FBgn0265356 transcript:FBtr0086573)

HSP 1 Score: 87.4261 bits (215), Expect = 4.203e-17
Identity = 35/82 (42.68%), Postives = 53/82 (64.63%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
             E LLTC VCL +Y  P++LPCQH+FC++PC+E L D   RQ+KCP CR  H      + + P N T++  +++ I+ T ++
Sbjct:    4 FEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGEL 85

HSP 2 Score: 59.3066 bits (142), Expect = 1.593e-8
Identity = 24/50 (48.00%), Postives = 33/50 (66.00%), Query Frame = 2

Query: 1148 IYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            +Y+ K   +   G +G+  G F WPRG+A+    N I++ADSSNHRVQVF
Sbjct: 1070 VYLRKRQQLFQLGGRGSEPGSFTWPRGLAV-GPDNSIVVADSSNHRVQVF 1118

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: tn (gene:FBgn0265356 transcript:FBtr0086572)

HSP 1 Score: 87.4261 bits (215), Expect = 4.203e-17
Identity = 35/82 (42.68%), Postives = 53/82 (64.63%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
             E LLTC VCL +Y  P++LPCQH+FC++PC+E L D   RQ+KCP CR  H      + + P N T++  +++ I+ T ++
Sbjct:    4 FEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGEL 85

HSP 2 Score: 59.3066 bits (142), Expect = 1.593e-8
Identity = 24/50 (48.00%), Postives = 33/50 (66.00%), Query Frame = 2

Query: 1148 IYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            +Y+ K   +   G +G+  G F WPRG+A+    N I++ADSSNHRVQVF
Sbjct: 1070 VYLRKRQQLFQLGGRGSEPGSFTWPRGLAV-GPDNSIVVADSSNHRVQVF 1118

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: tn (gene:FBgn0265356 transcript:FBtr0340448)

HSP 1 Score: 87.4261 bits (215), Expect = 4.216e-17
Identity = 35/82 (42.68%), Postives = 53/82 (64.63%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
             E LLTC VCL +Y  P++LPCQH+FC++PC+E L D   RQ+KCP CR  H      + + P N T++  +++ I+ T ++
Sbjct:    4 FEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGEL 85

HSP 2 Score: 59.3066 bits (142), Expect = 1.655e-8
Identity = 24/50 (48.00%), Postives = 33/50 (66.00%), Query Frame = 2

Query: 1148 IYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            +Y+ K   +   G +G+  G F WPRG+A+    N I++ADSSNHRVQVF
Sbjct:  994 VYLRKRQQLFQLGGRGSEPGSFTWPRGLAV-GPDNSIVVADSSNHRVQVF 1042

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: tn (gene:FBgn0265356 transcript:FBtr0340447)

HSP 1 Score: 87.4261 bits (215), Expect = 4.249e-17
Identity = 35/82 (42.68%), Postives = 53/82 (64.63%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
             E LLTC VCL +Y  P++LPCQH+FC++PC+E L D   RQ+KCP CR  H      + + P N T++  +++ I+ T ++
Sbjct:    4 FEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGEL 85

HSP 2 Score: 59.3066 bits (142), Expect = 1.674e-8
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 2

Query: 1142 QSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            + +Y+ K   +   G +G+  G F WPRG+A+    N I++ADSSNHRVQVF
Sbjct:  963 KQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAV-GPDNSIVVADSSNHRVQVF 1013

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim59 (tripartite motif containing 59 [Source:ZFIN;Acc:ZDB-GENE-060724-2])

HSP 1 Score: 63.1586 bits (152), Expect = 7.233e-10
Identity = 38/100 (38.00%), Postives = 53/100 (53.00%), Query Frame = 2

Query:   92 IIKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFD--VNFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCP 364
            ++  +E+ LTCSVC   + DPRVLPC HTFC K CLE +    VNF         +KCP CR V       + +LP N  +R+I++    ++      CP
Sbjct:   19 VMDSLEEDLTCSVCYALFTDPRVLPCSHTFC-KSCLESVLQVSVNFSIWRPLRLPLKCPNCRSVVELPTNGLDALPVNVCLRAIVEKYQRESRPRSPSCP 117

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim2a (tripartite motif containing 2a [Source:ZFIN;Acc:ZDB-GENE-050327-99])

HSP 1 Score: 63.5438 bits (153), Expect = 1.060e-9
Identity = 54/209 (25.84%), Postives = 91/209 (43.54%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD---------MSIDKTEKIDQL-------------------CPLCNALISDLXXXXXXXXXXXXXXYKI---HINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILE-INQSFNDMLTVLKERKTELL 643
             L CS+CL +Y++P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++M+         +S D T+ I+ +                   CP C   + +       ++        +   H    +E L A+ N L      E E   ++LS+I    S ++  I E I+ +F ++   L  RK+ LL
Sbjct:   20 FLICSICLDRYNNPKVLPCLHTFCER-CLQNYIPSHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLKKSPNSNLSEDYTDAINGVATGQPLSCPNHGGNVMEFYCPPCETAMCEECTSGEHAEHATVPLKDVLEQHKASLQEQLDAVKNRLP-----EIESALEVLSEILQQLSSQKSSIEEMIHATFEELQKTLNVRKSVLL 222

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim13 (tripartite motif containing 13 [Source:NCBI gene;Acc:553630])

HSP 1 Score: 60.8474 bits (146), Expect = 4.246e-9
Identity = 66/237 (27.85%), Postives = 106/237 (44.73%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVN----FR-QIKCPLCR--FVHCFAKGYITSLPKNFTIRSIMD----------MS---IDKTEKIDQLCPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQS-------FNDMLTVLKERKTELLD-------AVRTKFQPRINGLKS-LEE 700
            ++ +E+ LTC +C   ++DPRVLPC H+FC K CLE + D N    +R   KCP CR   VH      I SL  N+++R I++          MS   +   + ++  C     LI          K       +    + K   + L   +      E  K  ++ S +  +ES K+K +  +++        F+ +L  L+ +++E+L        AV   F P IN L+S LEE
Sbjct:   11 MELLEEDLTCPICCCLFEDPRVLPCSHSFC-KKCLEGILDGNRSPTWRPPFKCPTCRKETVH----NGIASLQVNYSLRGIVEKYNRIRVMPRMSQCRVHSGQPLNIFCATDLKLICGFCATTGDHKGHKFCALEEAYEREKLAFEELFRVV------EGWKGAEVHSCLESLESAKKKALERVSRDADRVSEYFDKLLRTLEHKRSEILSDLETLKLAVMQTFDPEINRLRSALEE 236

[Close]

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVN----FR-QIKCPLCR--FVHCFAKGYITSLPKNFTIRSIMD----------MS---IDKTEKIDQLCPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQS-------FNDMLTVLKERKTELLD-------AVRTKFQPRINGLKS-LEE 700
            ++ +E+ LTC +C   ++DPRVLPC H+FC K CLE + D N    +R   KCP CR   VH      I SL  N+++R I++          MS   +   + ++  C     LI          K       +    + K   + L   +      E  K  ++ S +  +ES K+K +  +++        F+ +L  L+ +++E+L        AV   F P IN L+S LEE
Sbjct:   11 MELLEEDLTCPICCCLFEDPRVLPCSHSFC-KKCLEGILDGNRSPTWRPPFKCPTCRKETVH----NGIASLQVNYSLRGIVEKYNRIRVMPRMSQCRVHSGQPLNIFCATDLKLICGFCATTGDHKGHKFCALEEAYEREKLAFEELFRVV------EGWKGAEVHSCLESLESAKKKALERVSRDADRVSEYFDKLLRTLEHKRSEILSDLETLKLAVMQTFDPEINRLRSALEE 236

[Close]

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVN----FR-QIKCPLCR--FVHCFAKGYITSLPKNFTIRSIMD----------MS---IDKTEKIDQLCPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQS-------FNDMLTVLKERKTELLD-------AVRTKFQPRINGLKS-LEE 700
            ++ +E+ LTC +C   ++DPRVLPC H+FC K CLE + D N    +R   KCP CR   VH      I SL  N+++R I++          MS   +   + ++  C     LI          K       +    + K   + L   +      E  K  ++ S +  +ES K+K +  +++        F+ +L  L+ +++E+L        AV   F P IN L+S LEE
Sbjct:   11 MELLEEDLTCPICCCLFEDPRVLPCSHSFC-KKCLEGILDGNRSPTWRPPFKCPTCRKETVH----NGIASLQVNYSLRGIVEKYNRIRVMPRMSQCRVHSGQPLNIFCATDLKLICGFCATTGDHKGHKFCALEEAYEREKLAFEELFRVV------EGWKGAEVHSCLESLESAKKKALERVSRDADRVSEYFDKLLRTLEHKRSEILSDLETLKLAVMQTFDPEINRLRSALEE 236

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000026455.1 (tripartite motif containing 59 [Source:NCBI gene;Acc:100493536])

HSP 1 Score: 67.3958 bits (163), Expect = 4.818e-11
Identity = 35/81 (43.21%), Postives = 46/81 (56.79%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEK--------LFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             ED LTCSVC   +DDPR+LPC HTFC + CLEK        L+  +   +KCP CR           +LP NF ++SI++
Sbjct:    4 FEDELTCSVCYNIFDDPRILPCSHTFC-RNCLEKVIHSSGSGLWRTSAAWLKCPSCRNTSELTMSGTLALPINFALKSIVE 83

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 65.0846 bits (157), Expect = 4.448e-10
Identity = 50/205 (24.39%), Postives = 92/205 (44.88%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM-------SIDKTEKIDQL----------CPLCNALISDLXXXXXXXXXXXXXXYKIH-----------INKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELL 643
             L CS+CL +Y +P+VLPC HTFC + CL+     +   + CP+CR      +  +++L  NF I ++MD+        I+++  ++ +          CP  +  + +     C +          H           + + K  LQA  + +KK L       + +   ++ + S K  ++ EI+ +F+D+   L  RK+ LL
Sbjct:   20 FLICSICLDRYKNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQRSPDNGIEESSILETVSAVAAGKPLSCPNHDGNVMEFYCQSCETAMCQDCTGGEHAEHPTVPLKDVVEQHKAALQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNVRKSVLL 223

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 65.0846 bits (157), Expect = 4.931e-10
Identity = 50/205 (24.39%), Postives = 92/205 (44.88%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM-------SIDKTEKIDQL----------CPLCNALISDLXXXXXXXXXXXXXXYKIH-----------INKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELL 643
             L CS+CL +Y +P+VLPC HTFC + CL+     +   + CP+CR      +  +++L  NF I ++MD+        I+++  ++ +          CP  +  + +     C +          H           + + K  LQA  + +KK L       + +   ++ + S K  ++ EI+ +F+D+   L  RK+ LL
Sbjct:   33 FLICSICLDRYKNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQRSPDNGIEESSILETVSAVAAGKPLSCPNHDGNVMEFYCQSCETAMCQDCTGGEHAEHPTVPLKDVVEQHKAALQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNVRKSVLL 236

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 64.6994 bits (156), Expect = 5.617e-10
Identity = 50/205 (24.39%), Postives = 92/205 (44.88%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM-------SIDKTEKIDQL----------CPLCNALISDLXXXXXXXXXXXXXXYKIH-----------INKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELL 643
             L CS+CL +Y +P+VLPC HTFC + CL+     +   + CP+CR      +  +++L  NF I ++MD+        I+++  ++ +          CP  +  + +     C +          H           + + K  LQA  + +KK L       + +   ++ + S K  ++ EI+ +F+D+   L  RK+ LL
Sbjct:   20 FLICSICLDRYKNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQRSPDNGIEESSILETVSAVAAGKPLSCPNHDGNVMEFYCQSCETAMCQDCTGGEHAEHPTVPLKDVVEQHKAALQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNVRKSVLL 223

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: sim2 (SIM bHLH transcription factor 2 [Source:Xenbase;Acc:XB-GENE-1013958])

HSP 1 Score: 55.0694 bits (131), Expect = 3.677e-7
Identity = 26/59 (44.07%), Postives = 36/59 (61.02%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQI-------KCPLCR 250
            ++ +E+ LTC +C   +DDPRVLPC H FC K CL+ + + N R +       KCP CR
Sbjct:    1 MEVLEEDLTCPICCSLFDDPRVLPCSHNFC-KKCLDGVLEENSRTMQWRPSSFKCPTCR 58

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim13 (tripartite motif-containing 13 [Source:MGI Symbol;Acc:MGI:1913847])

HSP 1 Score: 67.0106 bits (162), Expect = 4.182e-11
Identity = 67/241 (27.80%), Postives = 112/241 (46.47%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQ-------IKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNA---------LISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRK--LLSDISYMESGKQKLIL-------EINQSFNDMLTVLKERKTELLD-------AVRTKFQPRINGLKSL--EETMEIN 715
            ++ +E+ LTC +C   +DDPRVLPC H FC K CLE L + N R         KCP CR     A G + SL  N++++ I++   +K  KI    P+C            ++D+     C  C  +  +  H+  + E+  A   N  ++L    E +R+   LS +  +E+ K+K +        ++ + F  +   L ++K E+L        AV   + P IN + ++  E+ M  N
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFC-KKCLEGLLEGNVRNSLWRPSPFKCPTCR-KETSATG-VNSLQVNYSLKGIVE-KYNKI-KISPKMPVCKGHLGQPLNIFCVTDM--QLICGICATRGEHTKHVFSSIEDAYAREKNAFESLFQSFETWRRGDALSRLDTLETNKRKALQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKINTILQEQRMAFN 234

[Close]

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQ-------IKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNA---------LISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRK--LLSDISYMESGKQKLIL-------EINQSFNDMLTVLKERKTELLD-------AVRTKFQPRINGLKSL--EETMEIN 715
            ++ +E+ LTC +C   +DDPRVLPC H FC K CLE L + N R         KCP CR     A G + SL  N++++ I++   +K  KI    P+C            ++D+     C  C  +  +  H+  + E+  A   N  ++L    E +R+   LS +  +E+ K+K +        ++ + F  +   L ++K E+L        AV   + P IN + ++  E+ M  N
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFC-KKCLEGLLEGNVRNSLWRPSPFKCPTCR-KETSATG-VNSLQVNYSLKGIVE-KYNKI-KISPKMPVCKGHLGQPLNIFCVTDM--QLICGICATRGEHTKHVFSSIEDAYAREKNAFESLFQSFETWRRGDALSRLDTLETNKRKALQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKINTILQEQRMAFN 234

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BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim2 (tripartite motif-containing 2 [Source:MGI Symbol;Acc:MGI:1933163])

HSP 1 Score: 61.2326 bits (147), Expect = 1.104e-10
Identity = 27/73 (36.99%), Postives = 43/73 (58.90%), Query Frame = 2

Query:  107 EDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
            +  L CS+CL +Y +P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++MD+
Sbjct:   18 KQFLICSICLERYKNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDV 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim59 (tripartite motif-containing 59 [Source:MGI Symbol;Acc:MGI:1914199])

HSP 1 Score: 64.6994 bits (156), Expect = 2.251e-10
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENVLQASGNFYIWRPLRIPLKCPNCRSIIEIASTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim59 (tripartite motif-containing 59 [Source:MGI Symbol;Acc:MGI:1914199])

HSP 1 Score: 64.6994 bits (156), Expect = 2.399e-10
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENVLQASGNFYIWRPLRIPLKCPNCRSIIEIASTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03601|NHL1_CAEEL (RING finger protein nhl-1 OS=Caenorhabditis elegans OX=6239 GN=nhl-1 PE=1 SV=2)

HSP 1 Score: 79.337 bits (194), Expect = 1.219e-13
Identity = 60/215 (27.91%), Postives = 100/215 (46.51%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKT----EKIDQL--------CPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEI 712
            +E LLTC +CL +Y  P++LPCQHTFC  PCLE   D   R +KCP CR  H      + +   N+T+   +++ +  T     +I++         C +C+   +D   C  C +  CK C + H++  K ++  L N +K+  +   E    L   +  M    +    EI + F+     LK+++   L  V T        + +L + +EI
Sbjct:   37 IEQLLTCPICLDRYKQPKLLPCQHTFCY-PCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEYIHRYNLERCKICDEK-ADCEPCAHCDRKACKECRQTHMDMLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLMEVDTFQATETRNMSNLRDVLEI 249

HSP 2 Score: 55.4546 bits (132), Expect = 2.554e-6
Identity = 25/51 (49.02%), Postives = 36/51 (70.59%), Query Frame = 2

Query: 1145 SIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            S++    + + +FG +G   G+F +PRGIAIDS  N +IIADS N+R+QVF
Sbjct:  878 SVFDPHGVHLFSFGEEGFHGGQFKFPRGIAIDSQEN-LIIADSGNNRIQVF 927

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CYB0|TRI13_MOUSE (E3 ubiquitin-protein ligase TRIM13 OS=Mus musculus OX=10090 GN=Trim13 PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 2.926e-10
Identity = 67/241 (27.80%), Postives = 112/241 (46.47%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQ-------IKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNA---------LISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRK--LLSDISYMESGKQKLIL-------EINQSFNDMLTVLKERKTELLD-------AVRTKFQPRINGLKSL--EETMEIN 715
            ++ +E+ LTC +C   +DDPRVLPC H FC K CLE L + N R         KCP CR     A G + SL  N++++ I++   +K  KI    P+C            ++D+     C  C  +  +  H+  + E+  A   N  ++L    E +R+   LS +  +E+ K+K +        ++ + F  +   L ++K E+L        AV   + P IN + ++  E+ M  N
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFC-KKCLEGLLEGNVRNSLWRPSPFKCPTCR-KETSATG-VNSLQVNYSLKGIVE-KYNKI-KISPKMPVCKGHLGQPLNIFCVTDM--QLICGICATRGEHTKHVFSSIEDAYAREKNAFESLFQSFETWRRGDALSRLDTLETNKRKALQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKINTILQEQRMAFN 234

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8IWR1|TRI59_HUMAN (Tripartite motif-containing protein 59 OS=Homo sapiens OX=9606 GN=TRIM59 PE=1 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 8.584e-10
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q922Y2|TRI59_MOUSE (Tripartite motif-containing protein 59 OS=Mus musculus OX=10090 GN=Trim59 PE=1 SV=2)

HSP 1 Score: 64.6994 bits (156), Expect = 1.678e-9
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
             E+ LTC +C   ++DPRVLPC HTFC + CLE +     NF         +KCP CR +   A   I SLP NF +R+I++
Sbjct:    4 FEEELTCPICYSIFEDPRVLPCSHTFC-RNCLENVLQASGNFYIWRPLRIPLKCPNCRSIIEIASTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|D2GXS7|TRIM2_AILME (Tripartite motif-containing protein 2 OS=Ailuropoda melanoleuca OX=9646 GN=TRIM2 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 3.374e-9
Identity = 27/71 (38.03%), Postives = 42/71 (59.15%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +Y +P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++MD+
Sbjct:   20 FLICSICLERYKNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDV 89

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4W3H7Q0 (RING-type domain-containing protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 139.813 bits (351), Expect = 2.072e-30
Identity = 118/410 (28.78%), Postives = 204/410 (49.76%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPL-CN--ALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDKSQY--TPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHER-TEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQ------SLPIT---LQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            LLTC VCL +Y  P++LPCQHTFC +PCL+ L +   R++KCP CR VH   +  ++  P N TI S +++ +++   ++   PL C+  +L  +L+ C  C K +C SC  +H+ + + +L+ L + L++++         L   ++ ++   + +  EI +S    +  LKER+  L+    T  Q  +  L+  +E +E+ +A +SS      +SL          L  L+     L  + +Y   P+ +    +  F+++T  +   +  FG + W+     P    +S+  E  +  + N  LN + R         + + +R   S +  + + +        SLP+T   LQ  Y  K      FGSKG+  G F WPRG+A+ S    +++ADSSNHRVQ+F
Sbjct:   19 LLTCPVCLDRYKRPKLLPCQHTFCQEPCLKGLVNEVNRKVKCPECRAVHKIPREGVSGFPNNRTILSFLEIPLEQIPGLNSNGPLTCHFCSLKEELAVCCHCEKHLCDSCQHLHMEQLRLDLKRLVSQLRRSVPKLSNALGALEQKLASLKQNVEAVRAEIRRSVERFIAELKEREQVLMLEAETLVQSAVRTLQLKQENLELELASISSHCDCVENSLKGSGRLPSSELWQLHKQSRELIGQIRYLDEPDEVQPKVL-RFTANTVALHTDVVKFGSVSWATKNSTPLQLLSSSFIEMYSPLTINNSLNPLPRMASNYLSSNSQLGQRASSSDSQALIIELLDMNHHMLSLPLTGRDLQLHYQEKGRLQFKFGSKGSDLGHFTWPRGVAV-SPEGHVVVADSSNHRVQIF 426

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: H3AR70 (RING-type domain-containing protein OS=Latimeria chalumnae OX=7897 PE=4 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 2.628e-30
Identity = 119/405 (29.38%), Postives = 191/405 (47.16%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI---DQL-CPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKT---LSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDKSQYTPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHERTEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQSLPITLQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            +E LLTC +CL +Y  P+VLPCQHTFCL+PCLE+L     +Q+KCP CR VH   +G I   P N TI S +++ +++  ++   D L C  C +   +L  C  C K IC  C  +H+ + + +L+ +   L++    +S  KE    L    + +      +  EI++S    ++ L+ER+  LL  V +  Q         +E MEI +A + S      + L     S   ++ LLN  +    +  +          +  FS+   +I   I+ FG + W+       P TN +++  ++ +         R     +R  T     P +    E PV        +L + Y  K      FG KG+  G F WPRG+A+ +    +++ADSSNHR+QVF
Sbjct:    9 IEQLLTCPICLDRYQRPKVLPCQHTFCLEPCLERLASNTTKQLKCPECRAVHRIPEGGIQCFPNNRTILSFLEIPLEQISEVATRDFLPCQTCGSK-EELFNCSHCQKSICNQCKHLHLEQLRMDLKRMIIRLRRAVLKISCTKE---TLDQKSASLRQNSVAVRSEISRSIEQCISRLREREKVLLSEVESIVQA--------QENMEIELASIFSQFDGVENRLDNKAASISEVIELLNRCKQLKEETKKLGKIEEEPCLLIRFSAHEESIHFDISKFGSVVWTTESVAQQPITNMSRNSDSQPT-------RLRPTTLGSRSPTI----PIEMTDIERPVPNFHMTGCSLLNNYKQKGHTKCKFGGKGSDLGHFTWPRGVAV-TPGGHVVVADSSNHRIQVF 389

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4W3H667 (RING-type domain-containing protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 137.887 bits (346), Expect = 8.775e-30
Identity = 120/434 (27.65%), Postives = 208/434 (47.93%), Query Frame = 2

Query:  101 FMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPL-CN--ALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDKSQY--TPENISNLDMGEFSSDTTNIKNLINNFGHLKWS---------------------NSEKPPSPPTNSNKHERTEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQ------SLPIT---LQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
             +E LLTC VCL +Y  P++LPCQHTFC +PCL+ L +   R++KCP CR VH   +  ++  P N TI S +++ +++   ++   PL C+  +L  +L+ C  C K +C SC  +H+ + + +L+ L + L++++         L   ++ ++   + +  EI +S    +  LKER+  L+    T  Q  +  L+  +E +E+ +A +SS      +SL          L  L+     L  + +Y   P+ +    +  F+++T  +   +  FG + W+                     NS +  +  T S+    +  + N  LN + R         + + +R   S +  + + +        SLP+T   LQ  Y  K      FGSKG+  G F WPRG+A+ S    +++ADSSNHRVQ+F
Sbjct:   17 LIEQLLTCPVCLDRYKRPKLLPCQHTFCQEPCLKGLVNEVNRKVKCPECRAVHKIPREGVSGFPNNRTILSFLEIPLEQIPGLNSNGPLTCHFCSLKEELAVCCHCEKHLCDSCQHLHMEQLRLDLKRLVSQLRRSVPKLSNALGALEQKLASLKQNVEAVRAEIRRSVERFIAELKEREQVLMLEAETLVQSAVRTLQLKQENLELELASISSHCDCVENSLKGSGRLPSSELWQLHKQSRELIGQIRYLDEPDEVQPKVL-RFTANTVALHTDVVKFGSVSWATKNSTPLQLLSSSLSRYQATQNSHRSITVSTQSSIEMYSPLTINNSLNPLPRMASNYLSSNSQLGQRASSSDSQALIIELLDMNHHMLSLPLTGRDLQLHYQEKGRLQFKFGSKGSDLGHFTWPRGVAV-SPEGHVVVADSSNHRVQIF 448

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BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A4W3H7P0 (RING-type domain-containing protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 4.402e-29
Identity = 118/430 (27.44%), Postives = 207/430 (48.14%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPL-CN--ALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDKSQY--TPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPP--SPPTNSNKHERTEQSGNEI-------------------LNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQ------SLPIT---LQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            LLTC VCL +Y  P++LPCQHTFC +PCL+ L +   R++KCP CR VH   +  ++  P N TI S +++ +++   ++   PL C+  +L  +L+ C  C K +C SC  +H+ + + +L+ L + L++++         L   ++ ++   + +  EI +S    +  LKER+  L+    T  Q  +  L+  +E +E+ +A +SS      +SL          L  L+     L  + +Y   P+ +    +  F+++T  +   +  FG + W+     P     ++ ++++ T+ S   I                   LN + R         + + +R   S +  + + +        SLP+T   LQ  Y  K      FGSKG+  G F WPRG+A+ S    +++ADSSNHRVQ+F
Sbjct:   39 LLTCPVCLDRYKRPKLLPCQHTFCQEPCLKGLVNEVNRKVKCPECRAVHKIPREGVSGFPNNRTILSFLEIPLEQIPGLNSNGPLTCHFCSLKEELAVCCHCEKHLCDSCQHLHMEQLRLDLKRLVSQLRRSVPKLSNALGALEQKLASLKQNVEAVRAEIRRSVERFIAELKEREQVLMLEAETLVQSAVRTLQLKQENLELELASISSHCDCVENSLKGSGRLPSSELWQLHKQSRELIGQIRYLDEPDEVQPKVL-RFTANTVALHTDVVKFGSVSWATKNSTPLQLLSSSLSRYQATQNSHRSITVSTQSSIEMYSPLTINNSLNPLPRMASNYLSSNSQLGQRASSSDSQALIIELLDMNHHMLSLPLTGRDLQLHYQEKGRLQFKFGSKGSDLGHFTWPRGVAV-SPEGHVVVADSSNHRVQIF 466

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BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A401Q575 (RING-type domain-containing protein OS=Scyliorhinus torazame OX=75743 GN=scyTo_0018139 PE=4 SV=1)

HSP 1 Score: 131.724 bits (330), Expect = 8.185e-28
Identity = 129/444 (29.05%), Postives = 201/444 (45.27%), Query Frame = 2

Query:  101 FMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQL----CPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDK-------SQYTPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSP----PTNSNK-HERTEQSGNEILNNVER-----------------SNCENTREKTYIIERPCKSIAYEIPVSV--KQSLPITLQSIYMTKSLPILTFGSKG-----TGS-----GEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
             +E LLTCSVCL +Y  P++LPCQHTFC +PCL  L D N R++KCP CR VH   +  +   P N TI   +D+S+ +      +    C LC  L  +L  C  C   +C SC++IH+ + + +L++L + +++ +    +  R L    + +    + +  +I  S    +  LKER+  LL  V +        L+S +E +E+ +A LSS       SL K++      L  L+     L D+        Q  P+ ++      F   T    N I NFG + W   +  PSP    P  S +  +R+  S     N+ +                  +N   +R +  + +RP      + P  V   Q +   L    +T    +L +  KG      GS     G F WPRG+A  +    +++ADSSNHRVQVF
Sbjct:    5 LVEQLLTCSVCLERYTRPKLLPCQHTFCQEPCLSGLVDQNAREVKCPECRRVHAIPREGVAGFPSNRTILGFLDISMGQISGQTNIGTLTCGLC-GLEKELGTCHHCQNQLCNSCHRIHMERVRWDLRSLVSQMRRFIPKLSDALRSLEQRSASVRENGESVRAKIRHSTERHMAELKEREQALLLEVESMIWSSGRTLRSKQEDLELGLATLSSHCDCVDSSLAKNSSLPSTKLWQLHQQSKELIDQVRQLEKPQQERPQILT------FVPSTAIYHNGI-NFGTVIWVTKDFTPSPIISSPLPSGQVVQRSYPSITSTPNSTDMYPPLPLTNSSSLLLKAPTNILTSRPQ--LGQRPNTLCPTDTPTLVIEPQDICNNLVGFRLTGRSLLLHYQEKGCMKRKIGSKGSDMGHFTWPRGVAA-TLEGELVVADSSNHRVQVF 437

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BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 64.6994 bits (156), Expect = 3.953e-10
Identity = 27/71 (38.03%), Postives = 43/71 (60.56%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +YD+P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++M++
Sbjct:   20 FLICSICLDRYDNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEV 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 64.3142 bits (155), Expect = 4.352e-10
Identity = 27/71 (38.03%), Postives = 43/71 (60.56%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +YD+P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++M++
Sbjct:   20 FLICSICLDRYDNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEV 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 64.3142 bits (155), Expect = 4.352e-10
Identity = 27/71 (38.03%), Postives = 43/71 (60.56%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +YD+P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++M++
Sbjct:   20 FLICSICLDRYDNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEV 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 64.3142 bits (155), Expect = 4.352e-10
Identity = 27/71 (38.03%), Postives = 43/71 (60.56%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +YD+P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++M++
Sbjct:   20 FLICSICLDRYDNPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEV 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim59 (tripartite motif containing 59 [Source:NCBI gene;Acc:103046621])

HSP 1 Score: 62.3882 bits (150), Expect = 1.249e-9
Identity = 36/82 (43.90%), Postives = 48/82 (58.54%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDV--NFR-------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
            +E+ LTCSVC   ++DPRVLPC HTFC K CLE +  V  NF         +KCP CR V       + +LP N  +R+I++
Sbjct:    4 LEEDLTCSVCYSLFNDPRVLPCSHTFC-KSCLENVVQVSANFSIWRPLRLPLKCPNCRSVVELPPNGVDALPINVCLRAIIE 84

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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010730.1 (pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 gene:ENSPMAG00000009719.1 transcript:ENSPMAT00000010730.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 6.777e-13
Identity = 36/85 (42.35%), Postives = 48/85 (56.47%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFR---------QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
            + F+E+ LTC VC   ++DPRVLPC HTFC + CLE +   +             KCP CR V        TSLP NF++R+I+D
Sbjct:    1 MNFLEEELTCPVCYSLFEDPRVLPCSHTFC-RGCLEDILQGSLHLSPWRPLRTPFKCPSCRHVCELPLTGFTSLPVNFSLRNIVD 84

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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: trim59 (tripartite motif containing 59 [Source:ZFIN;Acc:ZDB-GENE-060724-2])

HSP 1 Score: 60.8474 bits (146), Expect = 4.257e-10
Identity = 29/86 (33.72%), Postives = 48/86 (55.81%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQ----------IKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
            ++ +E+ LTC VC   +++PRVLPC HTFC + CLE +      Q          +KCP CR +       ++ LP N+++ +I++
Sbjct:    1 MEHLEEDLTCPVCFSLFEEPRVLPCSHTFCRR-CLESVLQATVEQFPLWRALRVPLKCPSCRHMFDMPSAGLSYLPLNYSLVAIVE 85

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005035.1 (pep scaffold:Pmarinus_7.0:GL476697:205350:209715:-1 gene:ENSPMAG00000004581.1 transcript:ENSPMAT00000005035.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.4546 bits (132), Expect = 1.636e-8
Identity = 25/43 (58.14%), Postives = 31/43 (72.09%), Query Frame = 2

Query: 1169 PILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            P L FG KGT  G F WPRG+A+ +    +I+ADSSNHR+QVF
Sbjct:    3 PRLRFGCKGTEEGRFTWPRGLAV-TPEGHLIVADSSNHRLQVF 44

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009943.1 (pep scaffold:Pmarinus_7.0:GL488567:275:4344:1 gene:ENSPMAG00000008992.1 transcript:ENSPMAT00000009943.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 49.2914 bits (116), Expect = 4.036e-6
Identity = 21/39 (53.85%), Postives = 28/39 (71.79%), Query Frame = 2

Query: 1181 FGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
             G  G+G G+F+ P+G+A+D    RI +ADS NHRVQVF
Sbjct:  476 LGGSGSGPGQFLRPQGVAVDPE-GRIAVADSRNHRVQVF 513

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010742.1 (pep scaffold:Pmarinus_7.0:GL476415:275167:281055:1 gene:ENSPMAG00000009730.1 transcript:ENSPMAT00000010742.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 45.8246 bits (107), Expect = 4.472e-6
Identity = 33/86 (38.37%), Postives = 46/86 (53.49%), Query Frame = 2

Query:   98 KFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFA--KGYITSLPKNFTIRSIMDMSIDKTEKI 349
            + +E+ LTCS+CL  Y DP +L C HTFC + C+  ++        CP CR V  F   +     L KNF + SI+D    + EKI
Sbjct:    7 RGLEEELTCSICLHLYVDPVLLGCPHTFC-RECIVSVWRDG--ACACPECRRVLPFGSKEEMRKQLEKNFKLASIVDRFCSR-EKI 88

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO41113 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5F1])

HSP 1 Score: 63.1586 bits (152), Expect = 2.526e-10
Identity = 36/97 (37.11%), Postives = 60/97 (61.86%), Query Frame = 2

Query:   98 KFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFR-QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD-MSIDKTEKIDQ--LCPLCNA 376
            K +ED +TC++C+  + DPR+LPC HTFC + CLE L + + + ++ CPLC+  +  A   I SL  NF I +++  +S   +E  D+  +C +C +
Sbjct:    7 KQLEDEVTCAICIEHFTDPRLLPCLHTFC-RHCLEDLAEHSGKGKLVCPLCKVEYEIAVADIPSLKVNFPINNLISILSFLTSEDSDKKPVCEMCES 102

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47715 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLM1])

HSP 1 Score: 63.1586 bits (152), Expect = 4.293e-10
Identity = 31/76 (40.79%), Postives = 42/76 (55.26%), Query Frame = 2

Query:   98 KFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
            K  E LL C +CL  Y  P+VLPC HTFC + CL+ +       I CP CR   C  K  +++L  NF I +++D 
Sbjct:    8 KLSEHLLKCPICLETYRTPKVLPCLHTFC-QHCLKGMIQSGENIIVCPTCRCEVCVPKEGVSALSTNFFINNMLDF 82

HSP 2 Score: 54.6842 bits (130), Expect = 1.611e-7
Identity = 26/60 (43.33%), Postives = 34/60 (56.67%), Query Frame = 2

Query: 1124 SLPITLQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVFYY 1303
            S+ +T +  Y      I TFGS+G G GEF  P  +AID      I+ D +NHRVQVF +
Sbjct:  456 SVNVTGRMNYKKLGKAIRTFGSEGAGGGEFSIPWAVAIDEENECFIVTDCNNHRVQVFDF 515

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO30616 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0A2])

HSP 1 Score: 61.6178 bits (148), Expect = 4.571e-10
Identity = 36/98 (36.73%), Postives = 58/98 (59.18%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKL--FDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM-----SIDKTEKIDQLCPLCNA 376
            +ED +TCS+C+  ++DPRVLPC H+FC + CLE+L        ++ CPLC+     +   ++SL  NF I SI+ +     S D  +K   +C +C++
Sbjct:    9 LEDEVTCSLCIEHFNDPRVLPCLHSFC-RHCLEELAVHSEGRGKLVCPLCKAEFQISPADVSSLKVNFMINSIISVLPLLTSEDSKKKT--VCQMCDS 103

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO33118 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST50])

HSP 1 Score: 62.003 bits (149), Expect = 4.677e-10
Identity = 36/98 (36.73%), Postives = 57/98 (58.16%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKL--FDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM-----SIDKTEKIDQLCPLCNA 376
            +ED +TCS+C+  ++DPRVLPC H+FC + CLE+L        ++ CPLC+     +   + SL  NF I SI+ +     S D  +K   +C +C++
Sbjct:   14 LEDEVTCSICIEHFNDPRVLPCLHSFC-RHCLEELAVHSEGRGKLVCPLCKAEFQISPADVLSLKVNFMINSIISVLPLLTSEDSKKKT--VCQMCDS 108

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO33115 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST44])

HSP 1 Score: 59.3066 bits (142), Expect = 4.914e-10
Identity = 31/76 (40.79%), Postives = 48/76 (63.16%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKL--FDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
            +ED +TCS+C+  ++DPRVLPC H+FC + CLE+L        ++ CPLC+     +   ++SL  NF I SI+ +
Sbjct:    9 LEDEVTCSICIEHFNDPRVLPCLHSFC-RHCLEELAVHSEGRGKLVCPLCKAEFQISPADVSSLKVNFMINSIISV 83

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim59 (tripartite motif containing 59 [Source:NCBI gene;Acc:101157717])

HSP 1 Score: 71.2478 bits (173), Expect = 1.494e-12
Identity = 37/82 (45.12%), Postives = 51/82 (62.20%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVN-----FR----QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
            +E+ LTCSVC + + DPRVLPC HTFC +PCLE L  V+     +R     IKCP CR V       + +LP N ++R+I++
Sbjct:    4 LEEDLTCSVCYQLFSDPRVLPCSHTFC-QPCLENLLQVSTNYSIWRPLRLPIKCPNCRSVVELPPAGVDALPSNVSLRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim59 (tripartite motif containing 59 [Source:NCBI gene;Acc:101157717])

HSP 1 Score: 70.8626 bits (172), Expect = 2.538e-12
Identity = 37/82 (45.12%), Postives = 51/82 (62.20%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVN-----FR----QIKCPLCRFVHCFAKGYITSLPKNFTIRSIMD 322
            +E+ LTCSVC + + DPRVLPC HTFC +PCLE L  V+     +R     IKCP CR V       + +LP N ++R+I++
Sbjct:    4 LEEDLTCSVCYQLFSDPRVLPCSHTFC-QPCLENLLQVSTNYSIWRPLRLPIKCPNCRSVVELPPAGVDALPSNVSLRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:101163547])

HSP 1 Score: 64.3142 bits (155), Expect = 4.428e-10
Identity = 27/71 (38.03%), Postives = 43/71 (60.56%), Query Frame = 2

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +Y++P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++MD+
Sbjct:   20 FLICSICLDRYENPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDV 89

[Close]

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +Y++P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++MD+
Sbjct:   20 FLICSICLDRYENPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDV 89

[Close]

Query:  113 LLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
             L CS+CL +Y++P+VLPC HTFC + CL+     +   + CP+CR      +  + +L  NF I ++MD+
Sbjct:   20 FLICSICLDRYENPKVLPCLHTFCER-CLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDV 89

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000015738.1 (SMESG000015738.1)

HSP 1 Score: 736.102 bits (1899), Expect = 0.000e+0
Identity = 394/398 (98.99%), Postives = 396/398 (99.50%), Query Frame = 2

Query:  104 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNALISDLXXXXXXXXXXXXXXYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINXXXXXXXXXXXXXXXXKDNVSHGHLLALLNSIQTTLPDKSQYTPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHERTEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQSLPITLQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVF 1297
            MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNALISDLSKCECCSKCICKSCYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLIL+INQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINVAVLSSSILSAADSLVKDNVSHGHLLALLNSIQTTLPDKSQ TPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHERTEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQ LPITLQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQ+F
Sbjct:    1 MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNALISDLSKCECCSKCICKSCYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYMESGKQKLILDINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEETMEINVAVLSSSILSAADSLVKDNVSHGHLLALLNSIQTTLPDKSQSTPENISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHERTEQSGNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQLLPITLQSIYMTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQIF 398

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000023375.1 (SMESG000023375.1)

HSP 1 Score: 60.077 bits (144), Expect = 5.982e-9
Identity = 29/84 (34.52%), Postives = 42/84 (50.00%), Query Frame = 2

Query:   98 KFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFD--------VNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
            +  ++LL C +CL  Y  P+ L C HTFC + CLE             ++R+  CPLCR       G +  LP NF + S+ +M
Sbjct:   88 EIQDELLICKICLENYKQPKSLSCLHTFCAE-CLENHIQGEVTYKKYSDYREFTCPLCRKRTTLPMGGVRKLPDNFVVASLFEM 170

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000023375.1 (SMESG000023375.1)

HSP 1 Score: 60.077 bits (144), Expect = 6.689e-9
Identity = 29/84 (34.52%), Postives = 42/84 (50.00%), Query Frame = 2

Query:   98 KFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFD--------VNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDM 325
            +  ++LL C +CL  Y  P+ L C HTFC + CLE             ++R+  CPLCR       G +  LP NF + S+ +M
Sbjct:   53 EIQDELLICKICLENYKQPKSLSCLHTFCAE-CLENHIQGEVTYKKYSDYREFTCPLCRKRTTLPMGGVRKLPDNFVVASLFEM 135

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 53.9138 bits (128), Expect = 4.424e-7
Identity = 33/89 (37.08%), Postives = 47/89 (52.81%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKL----FDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
            I+ +EDLLTC + L   D+PR L C H FCL  CLE       + + +QI CPLCR         I SL  +F  + + +   +K +K+
Sbjct:   43 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLS-CLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKV 130

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 53.9138 bits (128), Expect = 4.434e-7
Identity = 33/89 (37.08%), Postives = 47/89 (52.81%), Query Frame = 2

Query:   95 IKFMEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKL----FDVNFRQIKCPLCRFVHCFAKGYITSLPKNFTIRSIMDMSIDKTEKI 349
            I+ +EDLLTC + L   D+PR L C H FCL  CLE       + + +QI CPLCR         I SL  +F  + + +   +K +K+
Sbjct:   52 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLS-CLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKV 139

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TRIM59	7.378e-11	42.68	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	7.449e-11	42.68	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	9.417e-11	42.68	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	1.120e-10	42.68	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	1.411e-10	42.68	tripartite motif containing 59 [Source:HGNC Symbol...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nhl-1	9.586e-15	27.91	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]
nhl-1	1.007e-14	27.91	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]
nhl-3	1.566e-7	24.36	NHL (Ring finger b-box coiled coil) domain contain...	[more]
lin-41	3.255e-7	55.81	pep chromosome:WBcel235:I:9335965:9342443:-1 gene:...	[more]
lin-41	3.255e-7	55.81	pep chromosome:WBcel235:I:9334812:9342496:-1 gene:...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tn	3.688e-17	42.68	gene:FBgn0265356 transcript:FBtr0114622	[more]
tn	4.203e-17	42.68	gene:FBgn0265356 transcript:FBtr0086573	[more]
tn	4.203e-17	42.68	gene:FBgn0265356 transcript:FBtr0086572	[more]
tn	4.216e-17	42.68	gene:FBgn0265356 transcript:FBtr0340448	[more]
tn	4.249e-17	42.68	gene:FBgn0265356 transcript:FBtr0340447	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim59	7.233e-10	38.00	tripartite motif containing 59 [Source:ZFIN;Acc:ZD...	[more]
trim2a	1.060e-9	25.84	tripartite motif containing 2a [Source:ZFIN;Acc:ZD...	[more]
trim13	4.246e-9	27.85	tripartite motif containing 13 [Source:NCBI gene;A...	[more]
trim13	4.246e-9	27.85	tripartite motif containing 13 [Source:NCBI gene;A...	[more]
trim13	4.246e-9	27.85	tripartite motif containing 13 [Source:NCBI gene;A...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000026455.1	4.818e-11	43.21	tripartite motif containing 59 [Source:NCBI gene;A...	[more]
actr6	4.448e-10	24.39	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]
actr6	4.931e-10	24.39	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]
actr6	5.617e-10	24.39	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]
sim2	3.677e-7	44.07	SIM bHLH transcription factor 2 [Source:Xenbase;Ac...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Trim13	4.182e-11	27.80	tripartite motif-containing 13 [Source:MGI Symbol;...	[more]
Trim13	4.182e-11	27.80	tripartite motif-containing 13 [Source:MGI Symbol;...	[more]
Trim2	1.104e-10	36.99	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]
Trim59	2.251e-10	42.68	tripartite motif-containing 59 [Source:MGI Symbol;...	[more]
Trim59	2.399e-10	42.68	tripartite motif-containing 59 [Source:MGI Symbol;...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q03601\|NHL1_CAEEL	1.219e-13	27.91	RING finger protein nhl-1 OS=Caenorhabditis elegan...	[more]
sp\|Q9CYB0\|TRI13_MOUSE	2.926e-10	27.80	E3 ubiquitin-protein ligase TRIM13 OS=Mus musculus...	[more]
sp\|Q8IWR1\|TRI59_HUMAN	8.584e-10	42.68	Tripartite motif-containing protein 59 OS=Homo sap...	[more]
sp\|Q922Y2\|TRI59_MOUSE	1.678e-9	42.68	Tripartite motif-containing protein 59 OS=Mus musc...	[more]
sp\|D2GXS7\|TRIM2_AILME	3.374e-9	38.03	Tripartite motif-containing protein 2 OS=Ailuropod...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4W3H7Q0	2.072e-30	28.78	RING-type domain-containing protein OS=Callorhinch...	[more]
H3AR70	2.628e-30	29.38	RING-type domain-containing protein OS=Latimeria c...	[more]
A0A4W3H667	8.775e-30	27.65	RING-type domain-containing protein OS=Callorhinch...	[more]
A0A4W3H7P0	4.402e-29	27.44	RING-type domain-containing protein OS=Callorhinch...	[more]
A0A401Q575	8.185e-28	29.05	RING-type domain-containing protein OS=Scyliorhinu...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim2a	3.953e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	4.352e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	4.352e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	4.352e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim59	1.249e-9	43.90	tripartite motif containing 59 [Source:NCBI gene;A...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000010730.1	6.777e-13	42.35	pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 ge...	[more]
trim59	4.257e-10	33.72	tripartite motif containing 59 [Source:ZFIN;Acc:ZD...	[more]
ENSPMAT00000005035.1	1.636e-8	58.14	pep scaffold:Pmarinus_7.0:GL476697:205350:209715:-...	[more]
ENSPMAT00000009943.1	4.036e-6	53.85	pep scaffold:Pmarinus_7.0:GL488567:275:4344:1 gene...	[more]
ENSPMAT00000010742.1	4.472e-6	38.37	pep scaffold:Pmarinus_7.0:GL476415:275167:281055:1...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41113	2.526e-10	37.11	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47715	4.293e-10	40.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30616	4.571e-10	36.73	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33118	4.677e-10	36.73	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33115	4.914e-10	40.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim59	1.494e-12	45.12	tripartite motif containing 59 [Source:NCBI gene;A...	[more]
trim59	2.538e-12	45.12	tripartite motif containing 59 [Source:NCBI gene;A...	[more]
trim2a	4.428e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	4.428e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	4.428e-10	38.03	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000015738.1	0.000e+0	98.99	SMESG000015738.1	[more]
SMESG000023375.1	5.982e-9	34.52	SMESG000023375.1	[more]
SMESG000023375.1	6.689e-9	34.52	SMESG000023375.1	[more]
SMESG000064098.1	4.424e-7	37.08	SMESG000064098.1	[more]
SMESG000064098.1	4.434e-7	37.08	SMESG000064098.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30004755 ID=SMED30004755|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2749bp
ATTTAATATTAATTTCTTTTAATTTAATGAATTGTTAATTAAATTTTGAA
TAGAATTTATTTTGAAATTTTTTGATTTAAATCTATGATAAATTATTAAA
TTTATGGAAGACTTATTAACTTGCTCAGTGTGTTTAAGAAAATATGATGA
TCCTAGAGTGTTACCATGTCAGCACACGTTTTGCTTAAAACCATGTTTGG
AAAAATTATTTGATGTAAATTTCCGCCAAATAAAATGTCCATTGTGTAGA
TTTGTCCATTGTTTTGCGAAAGGTTATATAACGTCTTTACCGAAAAACTT
TACAATTCGTAGCATAATGGATATGTCGATTGATAAAACGGAAAAAATTG
ACCAACTGTGTCCATTGTGCAATGCTCTAATCAGCGATCTATCCAAGTGT
GAATGCTGCTCGAAATGTATCTGTAAATCTTGCTACAAGATCCACATAAA
TAAGACAAAAGAAAATTTACAGGCATTGAGCAATAATTTGAAGAAAACTT
TATCTACTGAAAAGGAAAAATTTCGAAAATTACTTTCTGATATATCATAC
ATGGAAAGTGGGAAACAAAAATTAATTTTAGAGATTAATCAATCTTTTAA
TGATATGCTAACTGTTCTAAAAGAAAGGAAAACAGAACTCCTAGACGCTG
TTCGTACAAAGTTTCAACCAAGAATAAACGGATTAAAAAGTTTAGAAGAG
ACAATGGAAATAAATGTAGCGGTATTATCAAGTTCGATTCTGTCTGCAGC
TGATAGTCTTGTAAAGGATAATGTGTCTCATGGACACTTGCTAGCATTGC
TAAACTCCATTCAAACGACATTACCAGATAAATCGCAATATACACCTGAA
AACATTTCAAATTTAGACATGGGCGAATTTTCTTCCGACACGACAAATAT
TAAAAATTTAATTAATAATTTTGGACATTTGAAATGGTCAAACTCTGAAA
AACCGCCATCACCGCCTACTAATTCCAATAAACATGAAAGAACGGAACAA
TCTGGTAATGAAATACTTAATAATGTCGAACGTTCAAATTGTGAAAACAC
ACGAGAAAAAACATACATAATTGAAAGGCCTTGCAAGTCAATCGCATATG
AAATCCCAGTTTCAGTGAAGCAATCATTGCCGATTACGCTACAGTCCATC
TATATGACTAAATCCCTACCGATTCTCACATTCGGCTCCAAAGGAACCGG
CTCTGGGGAATTTATCTGGCCCCGTGGCATAGCGATTGATAGCTCCACAA
ATAGAATAATTATTGCAGATAGCAGTAATCATCGCGTGCAAGTATTTTAT
TACATTATATATTCACCAGTAATATTTCTTCATTTTTTTACATTTTTCTC
ATTTACCTTGTTTGACATGTTTGAAGGATTTAATTAATGCATTTACTGAT
TACTAGAGATTTTCACTGAGATCGAGGAGTTTAGGAAAAATATAATGATA
GATATTTAGTTATTTGTTTGCTGTGAAAATATGAACAAATTACATTGATT
GAATCACTATTGGGAGATATAATAAGAATTTCTAGTAATCAAAAAGGATT
TTCGAATGATTAAAAATGGTACAGAAAAGGAAAGAATAAACCGAAAGATG
TAAGGAAGTATGGAAATAAAAAAATCATTCGAAATTAAAATAATATTCAA
GAAAAACATAAAAAAGTCCAAAGTATAGATGACGGGTTACTCGGTATTGT
TTGGGCCAATATTTAAAAGTAAGCAAAGCATATCACTCAAGCAAAGCTGG
ATGAGGTGGGACCCTGGGGACAGCTTTATGATACTATATCAACACGATGA
ACAACTTTTGCTAATTAAATTGTGCTCTATCTTGGCATTATGATTAGGGC
CTTTGGGTCAAGGTCAGGATCACTGTTTATGCTGCAGTGTCACTTTGGCC
TATATTTGGGGCCCTCATTCCGAGGAACAGCAACGAAAATTCCCCACCCC
CAACAAGGACTACCCCCGTGCCAAATTTCATCGAGATCGGTCCAACGGCT
TGATTGTCTATACAGAACATACAAACAAATATTGCCCTTTATATTAGATG
TCAAAATTATTAATCTTCAAATCTCTTTGGATATTGGTAGAGTTATTTTG
GTGACAAATCTTGACATTTGTTTAACGGTCTAAAAAACAATTGTATTAAA
TGAACGGTTGATAATCATTTTGAGGAATATCTAAGAAATTTGCACCCATT
TAGAAATAAATAAAACATAAGTTAGGTACACTTTTCCAGTGCCTGATAAA
GGAGGAACTAGTGCAAAACTATATGGGTCCAAATTTCAAGATGGAATTCT
AATAATTCCAAAATTTAATACGTTTTATGTTAAAATAAATTTTGCCATAA
AACAGGTTAAATCTTTTTCTTATATTTATAAAAAGTATTTATATATTATG
AAAATTTTAATAAATCATATTCGAAATTTTCTTAATTACTATATTTGTGG
GTGAGTAATTATAGCTCGCTACAGCCCTGCAATTTGTTACAAATATGTTA
TAAAAGATGAAAATTTGTCCTTTATAATTAAAATTATGATTGCATCAAAA
TCGTAATATTATTTAAAGAATCGATAAGAATAATTAATCATAATTTACAA
TGCACTTAACATAGATACAGATTTTTTATATTTTTTGCATTGCAGTTGAA
CTGGTAATAATATTTTCTTAGTGAATTTATTTAAAATTATGTTTGATATA
TTTCAACTTTAGTATATAATGTATATTTATTCTTAACATAATAAAAATC

protein sequence of SMED30004755-orf-1

>SMED30004755-orf-1 ID=SMED30004755-orf-1|Name=SMED30004755-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=428bp
MEDLLTCSVCLRKYDDPRVLPCQHTFCLKPCLEKLFDVNFRQIKCPLCRF
VHCFAKGYITSLPKNFTIRSIMDMSIDKTEKIDQLCPLCNALISDLSKCE
CCSKCICKSCYKIHINKTKENLQALSNNLKKTLSTEKEKFRKLLSDISYM
ESGKQKLILEINQSFNDMLTVLKERKTELLDAVRTKFQPRINGLKSLEET
MEINVAVLSSSILSAADSLVKDNVSHGHLLALLNSIQTTLPDKSQYTPEN
ISNLDMGEFSSDTTNIKNLINNFGHLKWSNSEKPPSPPTNSNKHERTEQS
GNEILNNVERSNCENTREKTYIIERPCKSIAYEIPVSVKQSLPITLQSIY
MTKSLPILTFGSKGTGSGEFIWPRGIAIDSSTNRIIIADSSNHRVQVFYY
IIYSPVIFLHFFTFFSFTLFDMFEGFN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR001841	Znf_RING
IPR011042	6-blade_b-propeller_TolB-like
IPR027370	Znf-RING_LisH
IPR001258	NHL_repeat
IPR013083	Znf_RING/FYVE/PHD
IPR013017	NHL_repeat_subgr

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 115..139
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 277..305
None	No IPR available	PANTHER	PTHR25462:SF261		coord: 99..399 coord: 2..114
None	No IPR available	PANTHER	PTHR25462	FAMILY NOT NAMED	coord: 99..399 coord: 2..114
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 2..69
None	No IPR available	TMHMM	TMhelix		coord: 397..419
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 7..48 e-value: 6.4E-5 score: 32.3
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 7..49 score: 10.984
IPR027370	RING-type zinc-finger, LisH dimerisation motif	PFAM	PF13445	zf-RING_UBOX	coord: 7..46 e-value: 3.2E-7 score: 30.2
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 1..84 e-value: 1.1E-16 score: 62.1
IPR011042	Six-bladed beta-propeller, TolB-like	GENE3D	G3DSA:2.120.10.30		coord: 346..400 e-value: 3.1E-13 score: 51.5
IPR001258	NHL repeat	PFAM	PF01436	NHL	coord: 372..398 e-value: 1.3E-8 score: 34.5
IPR013017	NHL repeat, subgroup	PROSITE	PS51125	NHL	coord: 360..401 score: 13.097

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RING-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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