Cytochrome P450

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNP-PDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            GF  FD  C +KYGK++  Y G  P+  + D +++K +++KE +  FT+R             +++ + ++W+R+R+L++PTFTSGKL++M P+I+   ++L + +        P+ +K++FGA +MDVI  T FG+ IDS  NP + FV N K+L  F F + F +   +FP L I   ++L     F +E   F   +++   + R + T K+  DFL LM+         DS++SK  +S K LS+ E++AQS++F+ AGYETT++ L+F+ Y LA +PD QQ L  EI   L ++     DT++ M  LD +V E+LR+ P A+R++RVC +DV +       +   KG ++ IP YA+H DP  W +PEKF   RF   +K     Y + PFG GPRNC+GMRFAL+ +K A++ +LQNF   PC+ET   L   + GLL P  P++LK+  R
Sbjct:   56 GFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL-IPILEVL-NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI---------DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNP-PDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G+ TFD  C +KY K++ +Y    PM  + D +++K +++KE +  FT+R             +++ + ++W+R+R+L++PTFTSGKL++M P+I+   ++L + +        P+ +K +FGA +MDVI  T FG+ IDS  NP + FV N K+L  F+  + FV+   +FP L  +   +      F ++   F   +++   + R K T K+  DFL LM+ +   +   DSE+ K      LS+ E+MAQS++F+ AGYETT++ L+F+ Y LA +PD QQ +  EI   L ++     DT++ +  LD +V E+LR+ P A+R++RVC +DV +       +   KG ++ IP Y +H DP  W +PEKF   RF   +K     Y + PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   L  ++ GLL P  PI+LK+  R
Sbjct:   54 RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEAL--NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDS---QNSKDSETHK-----ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRLGGLLQPEKPIVLKVESR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNP-PDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G+ TFD  C +KY K++ +Y    PM  + D +++K +++KE +  FT+R             +++ + ++W+R+R+L++PTFTSGKL++M P+I+   ++L + +        P+ +K +FGA +MDVI  T FG+ IDS  NP + FV N K+L  F+  + FV+   +FP L  +   +      F ++   F   +++   + R K T K+  DFL LM+ +   +   DSE+ K      LS+ E+MAQS++F+ AGYETT++ L+F+ Y LA +PD QQ +  EI   L ++     DT++ +  LD +V E+LR+ P A+R++RVC +DV +       +   KG ++ IP Y +H DP  W +PEKF   RF   +K     Y + PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   L  +  GLL    PI+LK   R
Sbjct:   54 RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEAL--NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDS---QNSKDSETHK-----ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FD  C +KYGK++  Y G  P+  + D ++++ +++KE +  FT+R  L          +++ + ++W+R+R+L++PTFTSGKL++M P+I+   ++L + +        P+ +K+IFGA +MDVI  T FG+ IDS  NP + FV + K+   F F +   +  ++FP L  +F  +      F K++  F   ++      R     K+  DFL LM+         DS++SK  +S K LS+ E+ AQS++F+ AGYETT++ L+F  Y LA +PD QQ L  EI   L ++     D ++ M  LD +V E+LR+ P A+R++R C +DV +       +   KG ++ IP YA+H DP  W +PE+F   RF    K +   Y + PFG GPRNC+GMRFAL+ +K A++ +LQNF   PC+ET   L     GLL P  PI+LK+  R
Sbjct:   54 RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL--NVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI---------DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-----NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNP-PDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G+ TFD  C +KY K++ +Y    PM  + D +++K +++KE +  FT+R             +++ + ++W+R+R+L++PTFTSGKL++M P+I+   ++L + +        P+ +K +FGA +MDVI  T FG+ IDS  NP + FV N K+L  F+  + FV+   +FP L  +   +      F ++   F   +++   + R K T K+  DFL LM+ +   +   DSE+ K      LS+ E+MAQS++F+ AGYETT++ L+F+ Y LA +PD QQ +  EI   L ++     DT++ +  LD +V E+LR+ P A+R++RVC +DV +       +   KG ++ IP Y +H DP  W +PEKF   RF   +K     Y + PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   L  +  GLL    PI+LK   R
Sbjct:   54 RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEAL--NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDS---QNSKDSETHK-----ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI-----NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496          

Query:  230 QKMGFHTFDKM---CRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRM-ELAFRSKRAHK-MLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIEL----LKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFT-FSFFNSFVIIF-LMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVR-VDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEI 1507
            +K+G+   +K      ++YG+ + +YFG     V+ +EE +K++ IK F  F+DR+    F S + ++ +L       W+  R+ I P F++GK++ M   I   ++L    L+++ S+       DI E F  LT+DVI +  F +  + Q + N+ F +NA++        +S VI    + P+L  L+R  L K+                +    R        D L L++       E+D        SK ++  E++     FLLAGYETT+T + + SY L+K P+ QQ LY EIME       +  D++  M  LD +  E+LR  PP +  ++R C  D+T+         + KG ++    + VH +P  W  PE+F   RF+   +K++    ++PFG+GPR CVGMRFA +E K  IV +L  FE+
Sbjct:   56 EKLGYDDSNKWFNELHKQYGETFGIYFGAQMNIVLSNEEDIKEVFIKNFSNFSDRIVPPIFDSNQLNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMQETIHSKVDLFLDILREKASSG---QKWDIYEDFQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNARKFIANIDIRHSKVIAASFILPELAPLWRA-LYKYTPLADAEIPLVEGLSNVYERRRGGEGSDSVDLLKLLLN-----REDDK-------SKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEA-KENGGLTYDSIHNMKYLDYVYKETLRCYPPVIHFINRRCLADITIRGQ-----FYPKGSVVTCLPHTVHLNPENWDSPEEFHPERFENWEEKSSS-LKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFEL 470          

Query:  230 QKMGFHTFDKM---CRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRM--ELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIEL----LKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIF--LMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVR-VDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEI 1507
            +K+G+   ++      ++YG+ + +Y+G     V+ +E+ +K++ IK F  F+DR    +   ++    +L       W+  R+ I P F++GK++ M   I+  ++L    L+++ S+       DI + F  LT+DVI +  F +  + Q + N+ F +NAK+  +        II   ++ P+L   F K L K+                +    R        D L L++       E+D        SK ++  E++     FLLAGYETT+T + + SY L+K P+ QQ LY EIME       +  D++  M  LD +  E+LR  PP +  + R+C +D+T+         + KG I+    + VH +P  W  PE+F   RF+   +K++    ++PFG+GPR CVGMRFA +E K  IV +L  FE+
Sbjct:   56 EKLGYDDANRWFNELHEQYGETFGIYYGSQMNIVISNEKDIKEVFIKNFSNFSDRSVPSIYEANQLTASLLMNSYSSGWKHTRSAIAPIFSTGKMKAMQETINSKVDLFLDILREKASSG---QKWDIYDDFQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNAKKYISNIDIRHSKIIAASVLLPELST-FWKALYKYTPLADAEIPLVEGLSNVYERRRGGEGSDSVDLLKLLLN-----REDDK-------SKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEA-KENGGLTYDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCREDITIRGQ-----FYPKGAIVVCLPHTVHRNPENWDSPEEFHPERFENWEEKSSS-LKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFEL 470          

Query:  242 FHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRME--LAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGI----ELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFT-FSFFNSFVI-IFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRV-DRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEI 1507
            +  ++K+ +Q +G+ + +YFG      + +EE +K++ IK F  F+DR    +   +K    +L       W+  R+ I P F++GK++ M   I   +    E+LK++ S+       DI + F  LT+DVI +  F +  + Q + N+ F +NA++  T     +S +I    +FP+L  L+ K+L ++    K           +    R        D L L++       E+D        SK ++  E++     FLLAGYETT+T + + SY L+K P+ QQ LY EIME       +  D++  M  LD +  E+LR  PP +   +R C +D+T+         + KG I+    + VH +P  W  PE+F   RF+   +K++    ++PFG+GPR CVGMRFA +E K  I  +L  FE+
Sbjct:   64 YDWYNKLHKQ-FGETFGIYFGTQLNINITNEEDIKEVFIKNFSNFSDRTPPPIIEDNKLKESLLQNTYESGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASSG---QKWDIYDDFQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNARKFITNIDIRHSKIISTSFLFPELSKLW-KVLYRFTDLAKAEIPLVEGLADVYERRRGGEGSDSVDLLKLLLN-----REDDK-------SKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEA-KENGGLTYDSIHNMKYLDYVYKETLRCYPPVIHFSNRRCLKDITIRGQ-----FYPKGAIVVCLPHTVHRNPENWDSPEEFHPERFENWEEKSS-SLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFEL 470          

Query:  227 VQKMGFH---TFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRM--ELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGI----ELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLF-TFSFFNSFVI-IFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVR-VDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEI 1507
            V ++G++    +      KYG ++ +Y G      V +EE +K+I I+ F  F+DRM  ++   ++    +L       W+  R+ I P F++GK++ M   +   I    E+LK++ S+       DI E F +L++D+I +  F +  + Q +  + F + A++         S+++ + L+ P+L  L+R +   ++F    + +  +    + + +R ++ +  ND   L+    ++ET              ++  E++     FL+AGYETT+T + F +Y LA+ P  QQ LY EI +       +  D++  M  LD +  ESLR  PP     +RVC  D+T+         + +   + +  Y +H +P+ W  P++F   RF+   +K++    ++PFG+GPR CVGMRFA +E K  I  +L  FE+
Sbjct:   55 VSRLGYNDTTQWHPTLHTKYGPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQLNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSG---QKWDIFENFQSLSLDIIGKCAFAIDSNCQRDRTDLFYVQARKFVGAVDLKKSWILPVSLILPELSWLWRFL---YKFSDLSAAELPLVKGLVDLYDRRRAGEGGNDSTDLLNLLIRRETIGK-----------MTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKT-KENAGLNYDSIHNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQ-----IYPEDSTLKVQPYTIHRNPANWESPDEFQPERFENWEEKSSS-LKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFEL 469          

Query:  269 QKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFR---SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGI-ELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNM------------QMAIDERA--KSTDKYNDFLALMMKAH------KKETENDSESSKLMD-SKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEI-MECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRV-DRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQY-----SFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            +KYG +Y +  G     V+ D E + ++ +K+F  F  R   A +   +K     L   +G  W+R+R L +PTF++  LRK+   + + + EL++     +     +D+ E +   TMD+I +   G +        N  +   K +F     N F+I  + FP +GI  R I  K+      S Q   D              Q   DE+A  + + +  DF+ L + A       + E E D   S+++   K L+ DEI+ Q  VFLLAGY+TTA +L++ SY LA +P+ Q+ L  E+  EC   + E+  D L  +  L+ +V E+LR+ P A  V +R C     L+T++   +  + G  I +  +++H DP +W D    D + F P+  ++  +       ++PFGMGPR C+GMR A++E+K  + +IL+N+      ET+  L    +  + P S +LLK+  R
Sbjct:   62 KKYGPVYGITEGVEKTLVISDPEFVHEVFVKQFDNFYGRKLTAIQGDPNKNKRVPLVAAQGHRWKRLRTLASPTFSNKSLRKIMGTVEESVTELVRSLEKASAEGKTLDMLEYYQEFTMDIIGKMAMGQE--KSLMFRNPMLDKVKTIFKEGRNNVFMISGI-FPFVGIALRNIFAKFP-----SLQMATDIQSILEKALNKRLEQREADEKAGIEPSGEPQDFIDLFLDARSTVDFFEGEAEQDFAKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEEVDREC--PDPEVTFDQLSKLKYLECVVKEALRLYPLASLVHNRKC-----LKTTNVLGMEIEAGTNINVDTWSLHHDPKVWGD----DVNEFKPERWESGDELFFAKGGYLPFGMGPRICIGMRLAMMEMKMLLTNILKNYTFETTPETVIPLKLVGTATIAP-SSVLLKLKSR 517          

Query:  245 HTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDR----MELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLIS----DGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSF-VIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAH---KKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIM---ECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSD-KTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGL 1558
            H+ D   R K  K+Y ++    P+  + D EL++Q+ IK F  FT+      E    +    K L  L+ + W+++R+ +TPTFTS K+R+M  LI     + ++ +++++  +   + +++K+ F   T DVIA   FG+Q++S  +PNN+F    +R+  F+F+    V+++++ PKL    R  +P  +    + F+  +     A+  R + +    D + L+M+A    K E E  +ES+   D    ++D+++AQ L+F  AG+ET AT L+F SY L  NP+ Q+ L  EI+   E LG E+ +  DTLM M  L+ +V ESLR  PPA  VDR+C  D  L+  + +  +  ++ D++ I + A+H DP  +P+PE+F   RFD +HK    Q++++PFG+G R+C+G R AL+EVK  I  ++  + + P   T  ++   ISG 
Sbjct:   59 HSIDLHLRLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQL--DAGTSELELKDFFTRYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALR--VPVMDMNNVDYFKKLVFG---AMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLG-EKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGF 504          

Query:  227 VQKMGFHTFDKMCRQKY---GKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKM---LTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-----GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMF-PKLGILFR-KILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGS--EREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTF-KISGLLGPISPILLKI 1591
            V+K  F   ++   +K+   G +  MY       ++ D + +KQ+MIK+F  F DR   AF + R   +   L  L+G++W  +R+ +TP FTSGK+++MS +I D     G  + K        +  ++IK++    T DVI    FG++ +S  +P+ +F    + +FT    ++ V  F+    +L    R K+LP       +  QFF+  ++  +D R K+  K NDF+  M++   ++ E   +   +  S  L+ +++ AQ+ VF +AG+ET+++T++   Y LA  PD QQ L  EI   L +    E+  D L  M  LD ++ E+LR  P    + R  T+D  +  SD   +   KG +  IP++ +H DP I+P+PEKFD  RFDP+  K     +++PFG GPRNC+G+RF  ++ K  +VS+L+ F+      T   L F K S LL     I LK+
Sbjct:   47 VKKYHFRDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRG--AFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPD------DLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSD---IVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506          

Query:  227 VQKMGFHTFDKMCRQKY---GKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKM---LTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-----GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMF-PKLGILFR-KILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGS--EREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTF-KISGLLGPISPILLKI 1591
            V+K  F   ++   +K+   G +  MY       ++ D + +KQ+MIK+F  F DR   AF + R   +   L  L+G++W  +R+ +TP FTSGK+++MS +I D     G  + K        +  ++IK++    T DVI    FG++ +S  +P+ +F    + +FT    ++ V  F+    +L    R K+LP       +  QFF+  ++  +D R K+  K NDF+  M++   ++ E   +   +  S  L+ +++ AQ+ VF +AG+ET+++T++   Y LA  PD QQ L  EI   L +    E+  D L  M  LD ++ E+LR  P    + R  T+D  +  SD   +   KG +  IP++ +H DP I+P+PEKFD  RFDP+  K     +++PFG GPRNC+G+RF  ++ K  +VS+L+ F+      T   L F K S LL     I LK+
Sbjct:   47 VKKYHFRDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRG--AFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPD------DLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSD---IVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506          

Query:  293 MYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELA--FRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNS--FVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDV-----TLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPIL 1582
            +Y    P  V+ D EL+K +MIK+F+ F +R+           +K L   +   W  +R  I+P FTSGK+++M PL+    + L+         T + +K++    T D+IA   FG++ ++  +  ++F  + + +F+ +      F IIF M P L  L R  L     F +E+ +F   ++   + ER ++ +K ND + +++   ++   N  + SK +D      D ++AQ+ VF  AG+ET+A+T+    Y LAKN   Q  L  EI++  G E  I+ + +  MP L  +V E+LR  P    ++R C+Q       TLE     +L    G  I +   AVH DP  WPDPEK+D  RF+  ++      ++MPFG+GPRNC+GMR  LL+ K  +V IL+N     C +T++ + +       P SP++
Sbjct:   73 VYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIF-MIPALASLARVKL-----FSRETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDL-----DYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMEL--PHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEW------APTSPVM 492          

Query:  293 MYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELA--FRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNS--FVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDV-----TLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPIL 1582
            +Y    P  V+ D EL+K +MIK+F+ F +R+           +K L   +   W  +R  I+P FTSGK+++M PL+    + L+         T + +K++    T D+IA   FG++ ++  +  ++F  + + +F+ +      F IIF M P L  L R  L     F +E+ +F   ++   + ER ++ +K ND + +++   ++   N  + SK +D      D ++AQ+ VF  AG+ET+A+T+    Y LAKN   Q  L  EI++  G E  I+ + +  MP L  +V E+LR  P    ++R C+Q       TLE     +L    G  I +   AVH DP  WPDPEK+D  RF+  ++      ++MPFG+GPRNC+GMR  LL+ K  +V IL+N     C +T++ + +       P SP++
Sbjct:   73 VYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIF-MIPALASLARVKL-----FSRETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDL-----DYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMEL--PHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEW------APTSPVM 492          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRA-HKMLTVLKGKDWERVRNLITPTFTSGKLRKM-------SPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDER------AKSTDKYNDFLALMMKAHKK-ETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            K GFH FD  C +KYG+++ +Y G  P+  + D+ ++K ++IKE +  FT+R    FR   A +  +++ +  DW R+R++++P+FTSG+L++M       S ++ D +    KR  +       DIKE FGA +MDV+  T F + IDS  NP + FV N K++  F   N   ++   FP +  +  K+   +  F      FF   +Q    +R        +T K  DFL LM+ +    + ++D E ++    K LS+ EI++QS++F+ AGYET+++TL+F+ Y LA NP+  + L  EI E   ++  +  +TLM+M  LDA + ESLR+ P A R++RVC + V +       L   K  ++ +P YA+H DP  W +PE F   RF   +K++   Y +MPFG+GPRNC+GMRFA + +K AIV ILQ F++  C ET   L    +GLL P  PI LK+  R+
Sbjct:   50 KDGFHVFDMDCFEKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRN--FRLNGALYDAVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGES------ADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKM--DFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTE----KGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLRLYPVAARLERVCKKTVEI-----NGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNGLLSPKDPIKLKLQPRK 503          

Query:   98 IKFLLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFR-SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            + + L F+V+ L+Y +G        KLG  GP P PF G  L   K GF  FD  C +KYGK++ +Y G  P+ +V D E++K IM+KE +  FT+R E+    +      ++ +K + W+R+R  ++P FTSG+L+++ P+     +   K +     + P+ IKE+    ++DV+  + F + IDS  NP++ FV N K    FS F+  ++   +FP +  L  K+      F +    FF   ++   DE   S  +  DFL LM++    + +    +S+    K L++ EI++QS +F+L GYETT+TTL+F+ + LA NPD  + L  EI +    +  I+ D LM M  L+  + ES+R+ P A R++RVC + V L       +   K  ++AIP Y ++ DP +W  P++F   RF P++K    QY+FMPFG+GPRNC+GMRFAL+ VK  +V +LQNF +  C+ET   +  +++ +  P  PI LK+  R+ 
Sbjct:    9 VTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTK-GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQPVKIKEVVAPYSLDVVTSSSFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKM--GISVFSRSIMNFFYTALRKIKDEHKDSNGRV-DFLRLMIQNQIPDDQAKDTTSE-QPVKGLTDHEILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLPTAPRLERVCKKTVELN-----GITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKET--QIPLELTPVFQPKVPITLKLTPRKR 501          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFR-SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            GF  FD  C +KYGK++ +Y G  P+ +V D E++K IM+KE +  FT+R E+    +      +T +K + W+R+R  ++P FTSG+L+++ P+     +   K +     + P+ IKE+  + ++DV+  + F + IDS  NP++ FV N K    F+ F  FV++  +FP +  L  K+      F K +  FF   ++  I E  K ++   DF  LM++    + +    +S+    K L++ EI++QS +F++ GYETT+TTL F+ Y LA NPD  + L  +I +    +  I+ D LM +  L+  + ES+R+ P A R++RVC + V +       +   K  +I IP Y ++ DP +W  P +F   RF P++K    QY+FMPFG+GPRNC+GMR+AL+ VK  +V +LQNF +  C+ET   +  +++ +  P  PI LK+  R+ 
Sbjct:   34 GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGDHEQPVKIKEVMASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLKFNLFGLFVLLLTVFPSIANLLGKM--GLSMFSKPTVDFFYKALR-KIKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSE-QPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLLPTAPRLERVCKKTVEM-----NGITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKET--QIPLELNPVFQPKVPITLKLTPRKR 480          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFR-SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            GF  FD  C +KYGK++ +Y G  P+ +V D E++K IM+KE +  FT+R E+    +      +T +K + W+R+R  ++P FTSG+L+++ P+     +   K +     + P+ IKE+  + ++DV+  + F + IDS  NP++ FV N K    F+ F  FV++  +FP +  L  K+      F K +  FF   ++  I E  K ++   DF  LM++    + +    +S+    K L++ EI++QS +F++ GYETT+TTL F+ Y LA NPD  + L  +I +    +  I+ D LM +  L+  + ES+R+ P A R++RVC + V +       +   K  +I IP Y ++ DP +W  P +F   RF P++K    QY+FMPFG+GPRNC+GMR+AL+ VK  +V +LQNF +  C+ET   +  +++ +  P  PI LK+  R+ 
Sbjct:   55 GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGDHEQPVKIKEVMASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLKFNLFGLFVLLLTVFPSIANLLGKM--GLSMFSKPTVDFFYKALR-KIKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSE-QPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLLPTAPRLERVCKKTVEM-----NGITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKET--QIPLELNPVFQPKVPITLKLTPRKR 501          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKM-------LTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETE-NDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            G   FD  C +KYGK++ +Y G  P+ +V D E++K +++KE  C+++ +    R KR   +       + ++K + W+R+R+ ++P FTSG+L+++ P+     +   K +    P+ P+ IKE+    ++DVI  + F + IDS  NP + FVIN K+   F+ FN  +++ L+FP L I  +K+      F K +  FF   ++   D+  K ++   DFL LM++    + +  DS++S+   +K L++ EI++QSLVF+L GYETT+TTL F+ Y LA NPD  + L  EI +    +  I  D LM M  L+  + ES+R+ P A R++R   + V +       L   +G ++ IP Y +  DP IW  P +F   RF P++K    QY+F+PFG+GPRNC+GMR+A++ +K  +V +LQNF +  C+ET   +  +I+    P  PI LK++ R 
Sbjct:   55 GLCNFDMECAKKYGKVWGIYDGRLPILMVTDLEVIKVVLVKE--CYSNFIN---RRKRTTGLAGPFSDGIIMVKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQPVKIKEVVAPYSLDVITSSSFSVDIDSINNPEDPFVINVKKFIQFNMFNPLLLLILLFPSLAIPLKKM--GVTLFSKSAMDFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSE-QPAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLLPTAPRLERSAKKTVVI-----NGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKET--QIPLEINVTFQPKVPITLKLIPRS 502          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRIS---NNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
             + G   FD  C +KYGK++ +Y G  P+  + D  ++K IM+KE +  FT+R +          +L + K + W+R+R +++PTFTSGKL++M PL++   ELL K I    NN    P+D+K IFG+ +MD++  T F + +DS  NPN+ FV NA+ LFTFSFFN   +I ++ P L  L  K+   + F   +   FF D +     +R K T +   DFL LM+ A   E ++  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A +PD Q+ L  EI   L ++     D LM M  +D ++ ESLR+ PPA+R+DRVC +  T+E +  T      G +I +P++A+H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K A+  +LQNF +  C++T   L     G L P  PI+L ++ +
Sbjct:   45 NRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVL-ISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINN--KEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVPLLDKM--NFCFLSLKILNFFKDAVASIKKKRQKGTHEDRVDFLQLMVDAQSNEGKSVPEEEK-HGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINESLRMFPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFALHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCKDTPVPLKICTKGYLKPTKPIILNLIPK 495          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD-TPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
             + G   FD  C +KYGK++ +Y G  P+  + D  ++K IMIKE +  FT+R +L         +L V K + W+R+R +++PTFTSGKL++M PL+    ELL K I     +  P+D+K IFG+ +MD++  T F + +DS  NPN+ FV NA+ LF FSFFN   +I ++ P L  L  K+   + F   +   FF D +     +R K T +   D L LM+ A   E E+  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A +PD Q+ L  EI   L ++     D LM M  +D ++ E+LR+ PPA+R+DRVC +  T+E +  T      G +I +P++ +H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K  +  +LQNF    C++T   L     G L P  PI+L ++ +
Sbjct:   53 NRKGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVL-VSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKIDNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKM--NFCFLSLKILNFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEK-HGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFVLHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKPTKPIILNLIPK 503          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD-TPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKST--DKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
             + G   FD  C +KYG ++  Y G  P+  + D  ++K IM+KE +  FT+R +          +L + K + W+R+R +++PTFTSGKL++M PL+    ELL K I     +  P+D+K IFG+ +MD I  T F + +DS  NPN+ FV NA+ LFTFSFF    +I ++ P L  L  K+   + F   +  +FF D +     +R K    D+  DFL LM+ A   E E+  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A+ PD Q+ L  EI   L ++     D LM M  +D ++ E+LR+ PPA+R+DRVC +  T+E +  T      G +I +P++A+H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K A+  +LQNF++  C++T   L     G L P  PI+L +V +
Sbjct:   53 NRHGLMEFDMKCFKKYGNVWGFYDGPQPVLAILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVL-MSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKIDNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKM--NFCFLSSKFLKFFKDAVASIKKKRQKGAHMDRV-DFLQLMVDAQSNEGESVPEEEK-HRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNIARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFALHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKPTKPIILNLVPK 503          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRIS---NNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQET 1525
             + G   FD  C +KYGK++ +Y G  P+  + D  ++K IM+KE +  FT+R +          +L + K + W+R+R +++PTFTSGKL++M PL++   ELL K I    NN    P+D+K IFG+ +MD++  T F + +DS  NPN+ FV NA+ LFTFSFFN   +I ++ P L  L  K+   + F   +   FF D +     +R K T +   DFL LM+ A   E ++  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A +PD Q+ L  EI   L ++     D LM M  +D ++ ESLR+ PPA+R+DRVC +  T+E +  T      G +I +P++A+H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K A+  +LQNF +  C++T
Sbjct:   45 NRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVL-ISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINN--KEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVPLLDKM--NFCFLSLKILNFFKDAVASIKKKRQKGTHEDRVDFLQLMVDAQSNEGKSVPEEEK-HGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINESLRMFPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFALHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCKDT 470          

Query:  260 MCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD-TPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            +  +K   LY +Y G  P+  + D  ++K IMIKE +  FT+R +L         +L V K + W+R+R +++PTFTSGKL++M PL+    ELL K I     +  P+D+K IFG+ +MD++  T F + +DS  NPN+ FV NA+ LF FSFFN   +I ++ P L  L  K+   + F   +   FF D +     +R K T +   D L LM+ A   E E+  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A +PD Q+ L  EI   L ++     D LM M  +D ++ E+LR+ PPA+R+DRVC +  T+E +  T      G +I +P++ +H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K  +  +LQNF    C++T   L     G L P  PI+L ++ +
Sbjct:   51 LGNRKVSILYVIYEGQKPLLAIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVL-VSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKIDNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKM--NFCFLSLKILNFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEK-HGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFVLHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKPTKPIILNLIPK 491          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            G   FD  C +KYGK + ++ G  P+ V+ D E++K +++KE F  FT+R E       + K +++ K ++W+R R L++PTFTSGKL++M P+I   G  L+K  +       P+ +K++ GA ++DVI  T FG+ +DS  NP + FV  AK +    FF+  V   ++FP L  ++  +      F K+S +FF   +    + R  S  K+  DFL LMM AH    + DS        K LS+ EI AQS+VF+ AGYETT++TL+F  Y LA +PD Q+ L  EI E L ++     DT+M M  LD ++ E+LR+ P   R++R C +DV L       +   KG  + IP YA+H DP  WP+PE+F   RF  ++K +   Y +MPFG+GPRNC+GMRFA + +K A+  ++QNF   PCQET   L     GLL P  PI+LK+V R
Sbjct:   56 GLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMS-KAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEML--NICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSH-------KALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVEL-----NGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            G   FD  C +KYGK + ++ G  P+ V+ D E++K +++KE F  FT+R E       + K +++ K ++W+R R L++PTFTSGKL++M P+I   G  L+K  +       P+ +K++ GA ++DVI  T FG+ +DS  NP + FV  AK +    FF+  V   ++FP L  ++  +      F K+S +FF   +    + R  S  K+  DFL LMM AH    + DS        K LS+ EI AQS+VF+ AGYETT++TL+F  Y LA +PD Q+ L  EI E L ++     DT+M M  LD ++ E+LR+ P   R++R C +DV L       +   KG  + IP YA+H DP  WP+PE+F   RF  ++K +   Y +MPFG+GPRNC+GMRFA + +K A+  ++QNF   PCQET   L     GLL P  PI+LK+V R
Sbjct:   56 GLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMS-KAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEML--NICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSH-------KALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVEL-----NGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFF---IDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            G   FD  C +KYGK + ++ G +P+ V+ D E +K +++K+    FT+R E       + K +++ K ++W+R R L++PTFTSG+L++M P+I    ++L K +        P+ +K++ GA +MDVI  T FG+ +DS  NP + FV  AK+     FF+  +   ++FP L  ++  +      F  +S +FF   +D MQ   + R  S  K+  DFL LMM +H    + DS        K  SN EI  QS++F+ AGYETT++TL+F  Y LA +PD Q+ L  EI + L ++     DT+M M  LD ++ E+LR+ P   R++RVC +DV L       +   KG ++ IP YA+H DP  WPDPE+F   RF  ++K +   Y ++PFG+GPRNC+GMRFAL+ +K A+  +LQNF   PCQET   L     G+L P  PI+LK+V R
Sbjct:   56 GIWKFDMECYEKYGKTWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVGIMS-KAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEML--NICMFPNDSIEFFKKFVDRMQ---ESRLDSNQKHRVDFLQLMMNSHNNSKDKDSH-------KAFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVEL-----NGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPR 497          

Query:  107 LLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            LLA  +V L+Y++G +   L  K G  GP PLPFLG +L+  K G   FD  C +KYGK + ++ G +P+  V D E +K +++KE F  FT+R +       + K +++ K  +W+R R L++PTFTSGKL++M P+I    ++L K +        P+ +K++ GA +MDVI  T FG+ +DS  NP + FV  AK+L  F FF+  +   ++FP L  ++  +      F K+S +FF   +    + R  S  K+  DFL LMM +H     N+S+    +  K LS+ EI AQS++F+ AGYETT++TL+F  + LA +PD Q+ L +EI E L ++     DT+M M  LD ++ E+LR+ P A R++RVC +DV L       +   KG  + IP YA+H DP  W +PE+F   RF  ++K +   Y ++PFG GPRNC+GMRFAL+ +K A+  I+QNF   PC+ET   L     GLL P  PI+LK+V R
Sbjct:   14 LLAISLV-LLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYK-GLWKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMS-KAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEML--NICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSH-----NNSKDK--VSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVEL-----NGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            G   FD  C +KYGK + ++ G  P+ V+ D E +K +++KE F  FT+R +  F      K +++ K ++W+R R L++PTFTSG L++M P+I    ++L K +        P+ +K++ GA +MDVI  T FG+ IDS  NP + FV NAK++  F +F+   +   +FP L  ++  +      F K+S +FF   +    + R  S  K+  DF+ LMM+A+ K  + DS        K LS  EI AQS++F+ AGYETT++ L+F  Y LA +PD Q+ L  EI E L ++     DT+M M  LD ++ E+LR+ P   R+ RVC +DV +       +   KG  + IP Y +H DP  WP+PE+F   RF  ++K +   Y ++PFG GPRNC+GMRFAL+ +K A++ +LQNF   PC+ET   L      LL P+ PI+LK+V R
Sbjct:   56 GLWKFDMECYEKYGKTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDF-FPVGIMSKSISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLSVALFPFLTPIYEML--NICMFPKDSIEFFKKFVDRMTENRLDSKQKHRVDFIYLMMEAYNKSKDKDSH-------KALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEI-----NGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKPIVLKVVPR 497          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD-TPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + GF  FDK C +KYGKL+ +Y G  P+  + D +++K +++KE +  FT+R           K +++ + ++W+R+R L++PTFTSGKL++M P+I+   ++L + +     +  P  +K+IFGA +MDVI  T FG+ +DS  NP + FV   K+L  F  F+   +   +FP L  LF  +      F ++   FF  +++   + R K  +K   DFL LM+         +S++SK+ DS K LS+ EI+AQS++F+ AGYETT++ L+FV Y LA +PD Q+ L +EI   L ++     DTL+ M  LD +V E+LR+ P A R++RVC  DV +       +   KG ++ IP +A+H DP  WP+PE+F   RF   ++     Y ++PFG GPRNC+GMRFAL+ +K A+  +LQNF   PC+ET   L     GLL P  P+LLK+V R
Sbjct:   54 RKGFWEFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFG-PVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEAL--NVSMFPRDVIDFFKTSVERMKENRMKEKEKQRMDFLQLMI---------NSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEI-----NGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FD  CR+KYGK++ ++ G  P+ V+ D +++K +++KE +  FT+R           K +++ + +DW+RVR L++PTFTSGKL++M P+I+   ++L K +        P+D+KEIFGA +MDVI  T FG+ IDS  NP + FV N +RL  FSFF+  ++   +FP L  +F  +      F K+   F   +++   D+R K   K   DFL LM+         +S++SK +DS K L + E++AQS++ L AGYETT++TL+F+ + LA +PD QQ L  EI   L ++     DTL+ M  LD +V E+LR+ P A R++RVC +DV +  +        KG I+ +P YA+H DP  W +P++F   RF   +K     Y + PFG GPRNC+GMRFAL+ +K A+V ++QNF    C+ET   L     GLL P  PI+LK+V R
Sbjct:   52 RKGIWDFDIECRKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSFG-PVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKGKPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQDPFVKNVRRLLKFSFFDPLLLSITLFPFLTPIFEAL--HISMFPKDVMDFLKTSVEKIKDDRLKDKQKRRVDFLQLMI---------NSQNSKEIDSHKALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVKMEYLDMVVNETLRLYPIAGRLERVCKKDVDINGT-----FIPKGTIVMMPTYALHRDPQHWTEPDEFRPERFSKKNKDNINPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSR 494          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            G   FD  C +KYGK + ++ G  P+ V+ D E++K +++KE F  FT+R E       + K +++ K ++W+R R L++PTFTSGKL++M P+I   G  L+K  +       P+ +K++ GA ++DVI  T FG+ +DS  NP + FV  AK +    FF+  V   ++FP L  ++  +      F K+S +FF   +    + R  S  K+  DFL LMM AH    + DS        K LS+ EI AQS+VF+ AGYETT++TL+F  Y LA +PD Q+ L  EI E L ++     DT+M M  LD ++ E+LR+ P   R++R C +DV L       +   KG  + IP YA+H DP  WP+PE+F   RF  ++K +   Y +MPFG+GPRNC+GMRFA + +K A+  ++QNF   PCQET   L     GLL P  PI+LK+V R
Sbjct:   56 GLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMS-KAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEML--NICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSH-------KALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVEL-----NGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:  236 MGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MG   FD  C +KYGK++ ++ G  P+  + D E++K +++KE F  FT+R +         K ++V K ++W+R R L++PTFTSG+L++M P+I    ++L K +        P+ +K++FGA +MDVI  T FG+ +DS  NP + FV   K+L  F FF+   +  ++FP L  ++  +      F K+S +FF   +    + R  S  K+  DFL LMM AH    + +S ++       LS+ EI AQS++F+ AGYE T++TL+FV + LA +PD Q+ L  EI   L ++     DT+M M  LD ++ E+LR+ P   R++RVC +DV +       +   KG ++ IP YA+H DP  WP+PE+F   RF  ++K +   Y ++PFG GPRNC+GMRFAL+ +K A+  +LQNF   PC+ET   L     GLL P  PI+LK+V R
Sbjct:   55 MGLWKFDVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMG-KAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEML--NICMFPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTA-------LSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEI-----NGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPIILKVVPR 497          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMD-SKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FDK C Q+YGK++ +Y G  P+  V D  ++K +++KE +  FT+R             L++ + ++W+R+R L++PTFTSGKL++M P+IS   +LL   +        P+ +K+IFGA +MDVI  T FG+ IDS  NP + FV N+K+L  FSFF+ F++  + FP L  +F  +      F K S  FF  +++   + R     K   D L LM+         +S++SK MD  K+LSN+E++AQ ++F+ AGYETT++ L+ ++Y LA +PD QQ L  EI     ++     D L  M  LD +V E+LR+ P A R++R C +DV +       +   KG ++ +P++ +H DP +WP+PE+F   RF   HK T   Y+++PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   L     GL  P  P++LKI+ R
Sbjct:   54 RKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVFTNRRSFGPLGA-MRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDPFLLSLIFFPFLTPIFEVL--NITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI---------NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHG-----VFVPKGTVVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPR 496          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRIS---NNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
             + G   FD  C +KYGK++ +Y G  P+  + D  ++K IM+KE +  FT+R +          +L + K + W+R+R +++PTFTSGKL++M PL++   ELL K I    NN    P+D+K IFG+ +MD++  T F + +DS  NPN+ FV NA+ LFTFSFFN   +I ++ P L  L  K+   + F   +   FF D +     +R K T +   DFL LM+ A   E ++  E  K    K LS+ EI+AQSL+F++AGYETT+TTL F++Y +A +PD Q+ L  EI   L ++     D LM M  +D ++ ESLR+ PPA+R+DRVC +  T+E +  T      G +I +P++A+H +P IWP+PE+F   RF  +++K    Y+F+PFG+GPRNC+GMRFAL+ +K A+  +LQNF +  C++T   L     G L P  PI+L ++ +
Sbjct:   45 NRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVL-ISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINN--KEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVPLLDKM--NFCFLSLKILNFFKDAVASIKKKRQKGTHEDRVDFLQLMVDAQSNEGKSVPEEEK-HGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINESLRMFPPAIRIDRVCKK--TMEINGVT---IPAGVVIVVPLFALHLNPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCKDTPVPLKICTKGYLKPTKPIILNLIPK 495          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEF-KCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNN-PPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FDK C QKYGK++  Y G  P+  + D +++K +++KEF   FT+R             +TV +G+ W+R+R++I+PTFT+GKL++M P+I   I++L   I      D  +++K+IFGA ++DVI  T FG+ IDS   PN+  +++ K+L +FSF +  +I+ L+FP L  +  K+        KE+  F ++  +  I +R KS  +   DFL LM+ +   +  N S S K  +S K L+  EI+AQ++ F+ AGYETT+TTL F++Y LA +P+ Q+ L  EI   L ++     DT+  M  LD +V E+LR+ P   R++R+C +     T++   +   KG ++ IP+Y +H DP  WP+PE+F   RFD + +K+   Y F+PFG GPRNCVGMRFALL +K A+V++LQNF + PC+ET   L  +  G + P  PI+LK+V R
Sbjct:   54 RKGILEFDKQCFQKYGKMWGFYDGRLPILAILDPDIIKIVLVKEFYTLFTNRRNFGLNGI-LDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKVAQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKM--NLSLLSKENIDFLVNASRRIIADRKKSNSRDRVDFLQLMIDS---QVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLATHPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQK-----TAEINGITIPKGTVMLIPVYVLHHDPEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPKKPIILKLVPR 502          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAK--STDKYNDFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FD+MC +KYGK++ ++ G  P+  V D  L+K I++KE +  FT+R +    S      L V + + W+R+R +++PTFTSGKL++M P+I+   E+L K I      D  + +K+IFGA +MDV+A T F + IDS +NPN+ FV N K+L   SF N  VI  ++FP +  L +K+  +      +   FF D       ER K  STD+  DFL LM+ +   ++ NDS      DS K+LS++EI+AQ+L+F+ AGYETT++TL+++SY LA +PD QQ L +EI   L ++      T+M M  LD +V ESLR+ PPA R++RVC + V L       +   KG ++ IP Y +H DP+ WP+PE+F   RF  D +++   Y+F+PFG GPRNC+GMRFALL  K A+V +LQNF    C++T   L       + P  PI+LK+V R
Sbjct:   54 RHGVLNFDQMCFEKYGKIWGIFDGRQPVLAVLDPILIKNILVKECYTIFTNRRKFGL-SGILELGLHVAEDEKWKRIRAILSPTFTSGKLKEMFPIINHYGEILVKNIEKKAANDEFVTMKDIFGAYSMDVVASTSFSVNIDSMSNPNDPFVTNIKKLLKISFLNPVVIFLVLFPFVTPLLKKM--EVTLLPSKVMDFFQDVFIKMKKEREKGSSTDRV-DFLQLMVDS---QSSNDSSKPAETDSYKSLSDEEILAQALIFVFAGYETTSSTLSYLSYNLATHPDVQQRLQDEIDANLTNKATPTYTTIMQMDYLDMVVNESLRLFPPAGRIERVCKKTVEL-----NGVTIPKGMVVIIPTYVLHHDPAYWPEPEEFRPERFSKDSRESVDPYTFLPFGAGPRNCIGMRFALLVTKVALVVLLQNFSFRTCKDTPIPLVMDTKSFMQPKQPIVLKMVPR 502          

Query:   74 LLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISD-GIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            L+  +  +   LLA  +V L+Y +G  +  L  KLG  GP PLPF+GN+L  QK GF  FD+ C +KYGK++ +Y G  P+  + D +++K +++KE +  FT+R             +++ + ++W+R+R+L++PTFTSGKL++M P+I+  G  L+K    N     PI++K+ FGA +MDVI  T FG+ +DS  NP + FV   K+   F F +  +    +FP L  +F  +      F KE+  FF +++    + R K   K+  DFL LM+         DS++SK M+S K L++ EI+AQS++F+ AGYETT++ L+F+ Y LA +PD QQ L  EI     ++     D LM M  LD +V E+LR+ P A+R++RVC +D+ +      +L   KG ++ IP YA+H DP  W +PE+F   RF   +K +   Y ++PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   +     GLL P  PI+L+I  R
Sbjct:    3 LIPDFAMETWVLLAISLV-LLYLYGIHSYGLFKKLGIPGPTPLPFVGNVLSYQK-GFWQFDEECYKKYGKMWGLYDGRKPVLAITDPDIIKTVLVKECYSVFTNRRSFG-PVGFMKSAISISENEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVKNMKQNAEKGKPINLKDFFGAYSMDVITATSFGVNVDSLNNPQDPFVEQTKKFLKFDFLDPLLFTITLFPFLTPVFEAL--NISVFPKEAINFFKNSVHKMKESRLKDKQKHRVDFLQLMI---------DSQNSKEMESHKALTDLEIVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDRTFPNKAPTTYDALMQMEYLDMVVNETLRLFPIAIRIERVCKKDIEI-----NRLFIPKGTVVMIPTYALHRDPKYWTEPEEFRPERFSKKNKDSIDPYIYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPMKLGTKGLLHPEKPIVLRIESR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTD-KYNDFLALMMKAHKKETENDSESSKLMDS-KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + G   FDK C Q+YGK++ +Y G  P+  V D  ++K +++KE +  FT+R             L++ + ++W+R+R L++PTFTSGKL++M P+IS   +LL + +         I+ KEIFGA +MDVI  T FG+ +DS  NP + FV  A++L  F F + F++  ++FP L   F  +      F + S +FF  +++   + R K    +  D L LM+         +S++SK  D+ K LS+ E++AQS++F+ AGYETT+++L+F++Y LA +PD QQ L  EI     S+   + D L  M  LD +V E LR+ P A R++RVC +DV +       +   KG ++ +P++++H DP +WP+PE+F   RF   +K +   Y+++PFG GPRNC+GMRFAL+ +K A+V +LQNF   PC+ET   L     GL+ P  PILLK+V R
Sbjct:   54 RKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVFTNRRSFGPLGA-MRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVRNLRKEAEKGNSINTKEIFGAYSMDVITSTAFGVNVDSLNNPRDPFVQYARKLLRFDFLDPFILSIILFPFLSPFFEVL--DITLFPRSSVKFFTQSVKRMKESRLKDQQMRRVDLLQLMI---------NSQNSKETDAHKALSDQELVAQSIIFIFAGYETTSSSLSFLAYILATHPDVQQKLQEEIDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHG-----VSVPKGTVMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTTLKLSSQGLIQPEKPILLKVVPR 496          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN-DFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            K GF  FD  C +KYGK++ +Y    P+  + D E+LK I+IKE +  FT+R          +  +++++  DW+R+R++++P+FTSG+L++M  ++      L + +          DIKEIFGA +MDV+  T F + IDS  NP++ FV N K++  F F N   +   +FP +  +  K+   + FF      FF   ++    +R  S +K   DFL LM+ + K E     +   +     L++ EI++QS++F+ AGYETT++TL+F  Y +A NP+  + L  EI +   +E  I  D +M M  LDA + ESLR+ PPA R++RVC + V +      +L   +  ++  P++ +H DP  WP+P+ F   RF   +K+    + +MPFG GPRNC+GMRFAL+ +K AIV ILQ F+++  +ET   L   ISGLL P  PI LK + R+
Sbjct:   54 KQGFQNFDLECFKKYGKVWGIYDARQPVLCIMDREILKTILIKECYSLFTNRRNFRLNGP-LYDAVSIIEDDDWKRIRSVLSPSFTSGRLKEMFGIMKTHSHTLVQNLGKTSKRGEAADIKEIFGAYSMDVVTSTAFSVDIDSLNNPDDPFVTNIKKMLKFDFLNPLFVAVALFPFIAPVLEKM--NFCFFPPAVMDFFYAALKKIKSQRVSSDNKKRVDFLQLMIDSQKSEKVEHHDKGAI---HGLTDHEILSQSMIFIFAGYETTSSTLSFFFYNIATNPETMKKLQQEIDQTFPNESLIQYDAVMNMDYLDAALSESLRLYPPAARLERVCKKTVEI-----NRLTIPQNTVVLAPVFPLHRDPEYWPEPDTFKPERFTKGNKENIDPFVYMPFGSGPRNCIGMRFALVTIKLAIVEILQRFDVILSEETKVPLELGISGLLAPKDPIKLKFIPRK 502          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDER-AKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            + GFH FD  C +KYGK++ ++ G  P+  + D+ ++K I++KE +  FT+R ++    +  +  L V K +DW+R+RN ++P+FTSG+L++M  ++      L K +  +  +  I +K++FGA +MDVI  T F + IDS  NP + FV N K++    F +   I+ ++FP    L  K+  K  FF +    FF+ +++    ER AK+     D L LM+ +   +TE+D +  ++   K LS+ EI++QS+ F+ AGYET+++TL+F  Y +A NP+  + L  EI +   ++  +  D +M M  L+A + ES+R+ P   R++RVC      ET +   L   +G  I IP++ +H DP  W DP  F+  RF   +K+    Y +MPFG GPRNC+GMRFALL +K AIV ILQ F+++        L   I   L P  PI LK + R +
Sbjct:   54 RKGFHAFDMECYRKYGKIWGIFDGREPVLSIADQTIVKSILVKECYTYFTNRRDVGLNGE-LYDALFVTKDEDWKRIRNHLSPSFTSGRLKEMFGIMKTHTNTLVKNLEKSRKNEGIAVKDVFGAYSMDVITSTAFSVDIDSMNNPKDPFVTNIKKMLDIDFLSPIFIVAMVFPFALPLLEKM--KISFFSQSVSDFFLGSLKKIKTEREAKNHKSRVDILQLMVDS---QTEDDQQGEEM--KKGLSDHEILSQSMSFIFAGYETSSSTLSFFFYNIATNPETMKKLQREIDQTFPNKTPVNYDAVMNMEYLEAALNESMRLFPVVARLERVCK-----ETIEINGLTIPQGTSIMIPVFPLHRDPEYWSDPSTFNPERFTKGNKENVDPYVYMPFGSGPRNCIGMRFALLAMKLAIVEILQRFDVINPDPNQVPLKLGIHPFLSPKYPIKLKFIPRAN 500          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTP-IDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDER-AKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            + GFH FD  C +KYGK++  + G   +  + D+ ++K I++KE +  FT+R +     +  +  L + K +DW+R+RN ++P+FTSG+L++M  +I      L K +  +  +T  + +KE+FGA +MDVI  T F + IDS  NP++ FV N K+L  F  F+   ++  +FP L  L  K+  K+  F      FF  +++    ER AK+     D L LM+ +   +TE + +  ++   K L++ EI++QS++F+ AGYET+++TL+F  Y +A NP+  + L  EI +   +   +  D +M M  LDA + ES+R+ P   R++RVC      ET +   L   +G  I IP++ +H DP  WPDP  F+  RF   +K+    Y +MPFG GPRNC+GMRFA L +K AIV ILQ F ++        L    +  L P  PI LK   R +
Sbjct:   54 RKGFHVFDMECYRKYGKIWGFFEGRDRVLCIVDKSIVKSILVKECYTYFTNRRDFGLNGE-LYDALFITKDEDWKRIRNHLSPSFTSGRLKEMFGIIQTHANTLVKNLEKSSKNTEGVAVKEVFGAYSMDVITSTAFSVDIDSMNNPDDPFVTNIKKLLDFDVFSPLFLLAGLFPFLIPLLEKM--KFSIFPAAVADFFFVSLKKIKAERKAKNHKSRVDILQLMVDS---QTEGEQQGEEM--KKGLTDHEILSQSMIFIFAGYETSSSTLSFFFYNIATNPETMKKLQQEIDQTFPNNAPVQYDAVMNMEYLDAALNESMRLFPSVARLERVCK-----ETIEINGLTIPQGTSIMIPVFPLHRDPEYWPDPSTFNPERFTKGNKENIDPYVYMPFGSGPRNCIGMRFAQLAMKLAIVEILQRFNVINPDPDQVPLKLGTNIFLAPKDPIKLKFPPRAN 501          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFR-SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDG----IELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            GF  FD  C +KYGK++ +Y G  P+ +V D E++K IM+K+ +  FT+R E+           +TV+K + W R+R  ++P FTSG+L+++ P+        IE LKKR     PD P+ +K++F   +MDV+A   F + IDS  NP++ F  + K+ F FSFF+   +  ++FP    +  K+   +  F K   +FF  +++   D+      K  DF+ LM++    + + +S SS+    K L++ EI++QS +F+L GYETT+TTL F+ Y LA NPD    L  EI E       +  D LM +  L+ ++ ES+R+ P A R++RVC + V L       +   K  ++ IP Y +H DP +W  PE+F   RF P++      Y FMPFG+GPRNCVGMRFAL+ +K  +V +LQNF +  C+ET   +  ++  L  P  P+ LK   R H
Sbjct:   55 GFQNFDTECYKKYGKVWGIYDGRLPILMVLDHEMIKSIMVKDCYSVFTNRREMNKELVGPFSDGITVVKDEKWRRIRGSLSPFFTSGRLKEIFPIAEKYGDRFIENLKKR----SPDGPVKVKDVFAPFSMDVVASASFSVDIDSINNPDDPFGAHIKKFFNFSFFSPLFLFLVLFPSAAGILGKM--GFSMFAKSDMEFFYTSLKKLKDQHNNMNHKRVDFMQLMIQGQISDHQAES-SSEEQPIKGLTDHEILSQSFIFMLGGYETTSTTLTFLLYNLATNPDCLNKLMKEIDEMFPHGAPVTYDALMKLEYLEMVINESMRLFPTAPRLERVCKKTVEL-----NGITIPKDTLVTIPAYVLHRDPQLWESPEEFRPERFSPENNID--PYLFMPFGLGPRNCVGMRFALMIMKLVVVKLLQNFNVETCKET--QIPLQLDTLFRPKVPVTLKFTPRAH 500          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFR-SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDG----IELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            GF  FD  C +KYGK++ +Y G  P+ +V D E++K IM+K+ +  FT+R E+           +TV+K + W R+R  ++P FTSG+L+++ P+        IE LKKR     PD P+ +K++F   +MDV+A   F + IDS  NP++ F  + K+ F FSFF+   +  ++FP    +  K+   +  F K   +FF  +++   D+      K  DF+ LM++    + + +S SS+    K L++ EI++QS +F+L GYETT+TTL F+ Y LA NPD    L  EI E       +  D LM +  L+ ++ ES+R+ P A R++RVC + V L       +   K  ++ IP Y +H DP +W  PE+F   RF P++      Y FMPFG+GPRNCVGMRFAL+ +K  +V +LQNF +  C+ET   +  ++  L  P  P+ LK   R H
Sbjct:   55 GFQNFDTECYKKYGKVWGIYDGRLPILMVLDHEMIKSIMVKDCYSVFTNRREMNKELVGPFSDGITVVKDEKWRRIRGSLSPFFTSGRLKEIFPIAEKYGDRFIENLKKR----SPDGPVKVKDVFAPFSMDVVASASFSVDIDSINNPDDPFGAHIKKFFNFSFFSPLFLFLVLFPSAAGILGKM--GFSMFAKSDMEFFYTSLKKLKDQHNNMNHKRVDFMQLMIQGQISDHQAES-SSEEQPIKGLTDHEILSQSFIFMLGGYETTSTTLTFLLYNLATNPDCLNKLMKEIDEMFPHGAPVTYDALMKLEYLEMVINESMRLFPTAPRLERVCKKTVEL-----NGITIPKDTLVTIPAYVLHRDPQLWESPEEFRPERFSPENNID--PYLFMPFGLGPRNCVGMRFALMIMKLVVVKLLQNFNVETCKET--QIPLQLDTLFRPKVPVTLKFTPRAH 500          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNN-PPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQ----FFIDNM--QMAID-ERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            GF  FD+   Q+YG+++ +Y G  P+ +V D  +LKQI++K+  + FT+  ++         + TV   + W+R+RN+++PTF+SGK+++M PLI    ++L K +         +D+K+  G   ++    T + + I     P    +++  ++   + +N  V  F     L  LF   +P +E+ G   F      F  N+  Q   D     ST    DFL LM+ A   ET  +  +      K L++ E+ AQ+++FLLAG+ETT+T + FV+Y LA NPD Q  +  EI E L  ++  + + L  M  LD +V E++R+ PPA R+DRVC +  T++      L   K  +I +  + +H DP  W +P +F   RF  + K+    Y ++PFG GPRNC+GMRFAL+ VK A+  ILQ +    C ET          +L    P+LLK+ +R+
Sbjct:   56 GFRAFDEESFQRYGRVWGIYDGRLPVLMVADTNMLKQILVKDCLEFFTNHRKIGLNELFGEGLSTV-DDEQWKRIRNILSPTFSSGKIKQMYPLILRCADVLVKNLHEKCQSGKSVDLKQGNGEWRLETNRVTAYKIFIALVKRPPPPLLLSRSKMININIYN--VQRF----SLSALFPVFVPLFEYMGLSLFPKKICIFFKNIVQQFKTDISMNYSTKGRVDFLQLMVDAQLSETVQNGANPH--SEKYLTDSELEAQAILFLLAGFETTSTAITFVAYCLACNPDVQTKVQQEIDEFLPDDKAPSYEILNEMEYLDMVVSETMRMYPPAARLDRVCKRTTTVDN-----LVIPKDVVITVSTWVLHYDPQHWEEPNEFRPERFTKEAKEARDPYCYLPFGQGPRNCIGMRFALMSVKIAVCRILQRYSFQMCSETTIPPKLAKGSILQTEKPLLLKVSERK 505          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP-DTPIDIK-EIFGALTMDVIA--RTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVII----FLMFP--KLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYN---DFLALMMKAHKKE-TENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            GF  FD    +KYG+++ +Y G  P+ +V D  +LKQI++K+  + FT+R +    S     +L + + + W+R+RN++TP F+ GK+++M PLI    E+L + +      + P+D+K E FG+  +D +      FG  +  +  P++      K +F   F   F +I    FL+ P  +LG+           F K++  FF   +Q   ++R K  +      DFL  M+ A   E T N +E         L++ E+ +Q+++FL+AGY+ T+T++ F++Y LA NPD Q  +  EI   L   +    +TL  M  LD +VCE+LR+   + R DRVC +     T+    L   KG ++ +P++ +H DP  W +P +F   RF  + K+    Y ++PFG GPRNC+GMRFAL+ VK A+  ILQ +    C ET     F  +  L    P+ +K+V R+
Sbjct:   56 GFREFDAESFRKYGRVWGIYDGRVPVLMVTDTNMLKQILVKDCLESFTNRRKFGL-SGPIKDVLLIAEDEHWKRIRNVLTPAFSGGKIKQMCPLIQRCAEVLVQNLHEPCQLEQPVDLKDEKFGSGILDHLEFEGEGFGEIVKQKVFPHDPVPKALKYIFLCEFSPLFAVILFFPFLISPLERLGV---------TLFDKKAIHFFHKIVQQMKNKRQKGLNDMQGRVDFLQQMVNAQLSENTSNGNED--------LTDGELESQAVLFLMAGYDNTSTSITFLAYCLACNPDVQTKVQQEIDTILPDGKLPDYETLKQMEYLDMVVCETLRMYSSSSRTDRVCKK-----TTVVNDLVIPKGVVVTVPLWVLHYDPQYWDEPHEFRPERFTKEAKEARDPYCYLPFGHGPRNCIGMRFALMSVKIAVCRILQRYSFQTCSETTIPPQFNKNTFLQLEKPLKVKVVARK 502          

Query:  239 GFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTP-IDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFG-----KESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            GF  FD+   +KYG+++  Y G  P+ VV D  +LK +++K+  + FT+R  +         M ++   + W+R+RN+++PTF+ GK+++M PLI    + L K +         +D+KE+  +  + +         I    N    F  +  R     F      I L  P    +F +++P  EF G     K++  FF   ++ +     K+     DFL LM+     ++  +  +      K L++ E+ AQ+++FLLAGYETT+T + FV+Y LA NPD Q  +  EI   L ++   + + L  M  LD +V E+LR+ PP  R DRVC +     T+    L   KG ++ +P++ +H DP  W +PE+F   RF  + K+    Y ++PFG GPRNC+GMRFAL+ +K  +  ILQ +    C ET        +  L   +P+L+++ +R+
Sbjct:   51 GFKEFDQNSFKKYGRIWGTYDGRLPLLVVADTSILKTVLVKDSLEFFTNRRNIGLNGPFKEAM-SIANDEKWKRIRNVLSPTFSGGKIKQMCPLIVRCADSLVKNLREKCQSGKLVDLKELHVSCKLRISLPKSLCALIGKYGN----FTSDTSRQMVLCFTG----INLTTP----IFPELVPPLEFLGLSFFPKKASSFFTTIVRQSDVNIKKNNKGRVDFLQLMVDVQLSKSMQNGANPH--SDKYLTDSELEAQAILFLLAGYETTSTAITFVAYCLACNPDVQTKVQQEIDRFLPNDTLPSYEILKQMEYLDMVVSETLRMYPPTSRTDRVCKK-----TTVVNDLVIPKGVVVTVPLWVLHYDPQYWDEPEEFRPERFSKEAKEARDPYCYLPFGQGPRNCIGMRFALMSMKIVVCRILQRYSFHACNETTIPPKLTKNPFLQLENPLLVQVSERK 492          

Query:  797 FGKESFQFFIDNMQMAIDERAKS--TDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            F K+   FF+ N+Q    ER K   TD+  DFL  M+ A   ++  D E   ++  K L++ EI++Q++VFLLAGYETTA TL +++Y LA + D Q  L  EI   L  E       L     L  +V ESLR+ PPA R++R+   DV L       +   KG +I IP++ +H     W DP  F   RF  + ++   QY ++PFG GPRNC+GMRFAL+ VK AIVS+L+ F  V C ET       I GLL P  PI+LK  +R H
Sbjct:   19 FPKDVLSFFMSNLQRLKSERRKGEHTDRV-DFLQTMVDAQISDSVMD-EHGGIIPYKALTDSEILSQAMVFLLAGYETTAVTLTYIAYNLAVHVDVQDKLLEEIDATLPPEAPYCYRIL-----LPHVVSESLRLYPPAGRLERIAKMDVEL-----GGIPVPKGTVIGIPVFVIHRHSEHWDDPTAFRPERFSKEAREQRDQYCYLPFGAGPRNCIGMRFALINVKIAIVSLLRRFTFVTCPETKIPAEIGIRGLLEPKEPIILKFAERNH 278          

Query:  425 LTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGI-ELLKK--RISNNPPDTPIDIKEIFG---ALTMDVIARTMFGMQIDSQTNPNNQFV--------INAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEI 1507
            L VL G  W R R L+TP F    L+    +I      +L K  R++   P       E+FG    L +  I +  F  + + QT   N +V        +  +R   F+  N +V  + + P  G  F+K         ++  +   + +++   +      +  DFL +++            SS+  D ++LS++EI  +    + AG++TTA+ L++V + LA NP  Q+   +E    L    +   D +  +P    ++ ESLR+ PP   + R  TQ + L            G  + + I+ +H +   W DPE FD  RF  ++      Y+F+PF  GPRNC+   FAL E++  +  IL  F I
Sbjct:  122 LLVLSGPKWFRNRRLLTPGFHYEILKPYIAIIGQSTASMLDKWERLTEKQPTL-----EVFGDISLLMLHSILKCAFSYEGNCQTEAGNSYVRAVYELTDLVHRRFRNFALHNKWV--YYLTPA-GRRFQKAKGHAHKHTEDVIRRRRETLKLEAQQDKTQQKRNLDFLDILL------------SSRDADGQSLSDEEIRTEVDTIMFAGHDTTASGLSWVLHALASNPHHQEVCRDEAARVLAGRSQPEWDDISNLPYTTMVIKESLRLYPPVPSIIRKLTQPLKLPHGH----VLPAGMRVCVSIFCIHRNEEFWKDPEVFDPLRFSQENSAHRHPYAFIPFSAGPRNCIDQNFALNELRVTVAMILSRFRI 472          

Query:  227 VQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTV-VGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGK----DWERVRNLITPTFTSGKLRKMS-----PLISDGIELLKK-----RISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMA-IDERAKSTD-KYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECL-GSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNG-----QYSF-----------MPFGMGPRNCVGMRFALLEV 1468
            V  M  + F + C++KYG ++     G  MTV +G +         EF       +++  +  AH + T + GK    D    R +    F  G L K +     PLI++ +    +     R++     T ID+      +T+   +R++ G ++ ++ + +  ++ +            F  I  +FP L        P   +  ++  Q  I    M+ I ER K+ D +  D +  +MK           +S   D   +++ EI    +  L+ G  T+A T A++   LA+ PD QQ+LY E M  L G ++E+  D L  MP+L+  + E+LR+  P   + R   +D+ +     T      G  + +     H     +P+  +F+ HR++ D   +        Y F           +PFG G   C+G  FA  ++
Sbjct:   71 VYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKG-------HEFVFNAKLADVSAEAAYAH-LTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGT-IDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYS-------DLDKGFTPINFVFPNL--------PLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMK-----------NSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPN---TSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQL 480          

Query:  269 QKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE--FKCFTDRMELAFRSKRAHKMLTVLK--GKDWERVRNLIT---------PTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQF---VINAKRLFTFSFFNSFVII-FLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWP------DPEKF--DYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKI 1591
            +KYG +   +FG     +V   E L QI   E  F    ++ ++ + +  A+    V+   G  W   RN +T         P F + K+            L+K R+      T I +  +   + +D I++   G    + T+  N F   +I  K+     FF +F  +  L  P     F+ ++   E   K      ++N +      A S          +++AH  E         ++D K L+++ +     + L+AG+E          Y LAK  +  Q+   + +  +   + +A+     +P+L+A + E +R+ PP   +   CT   T       ++   KG  +    +    DP  W        PE++  D      + +    + +   F  G R C+G + AL E++ ++  +L+ F      E  E LT       GP+ P+ LK+
Sbjct:   64 EKYGAV-KFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVISAYGAVWRNYRNAVTNGLQHFDDAPIFKNAKIL---------CTLIKNRLLEG--QTSIPMGPLSQRMALDNISQVALGFDFGALTHEKNAFHEHLIRIKKQIFHPFFLTFPFLDVLPIPSRKKAFKDVVSFRELLVKRVQDELVNNYKFEQTTFAASD---------LIRAHNNE---------IIDYKQLTDNIV-----IILVAGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGITDPKGLAD-----LPLLNAFLFEVVRMYPPLSTIINRCT---TKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLT-----PAGPLCPLNLKL 481          

Query:  794 FFGKE----SFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSE--REIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVG-----MRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            ++GK+    + + F +  QMA D  A          A     H  +  ND +S   +  +  +N EI      FL A  + +++   ++   +A  PD    +  E +    ++   E+  D +  M   + ++ E+LR  PP + V  V  ++  +  +        KG ++   +Y    DP ++ +P++F   R+    K +  + +++ FG GP  C+G     + FA L  K+A+ +   +  + P  E +     K+   + P   +LL   KR
Sbjct:  262 WYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSR--IYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAP----KGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHH-TVTPLSEKI-----KVFATIFPKDDLLLTFKKR 529          

Query:  269 QKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDR-MELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDT-PIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTF-SFFNSFVIIF-LMFPKLGILFRKI-LPKWEFFGKESFQFFIDNMQMAIDERAKS-TDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSERE-IANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            + YG+L   Y G     +V D E+ KQI++KEF  F +R +  + ++    K L  L+  DW R+R+ ITPTF++ KL+++ PLI++   +L +++     D   +D+   +G  TM+ I  T FG+   +QTNPN+QFV NA+RLF   S F    ++F  + P + ++ +++ L K    GK S  F +D  +  I  R ++ +    D L +++ A   ET +D    K      LS+DEI+AQ   F+LAGYETT+ T+AF SY LA NPD Q  L  EI E   +  +    DT++ M  L+ +V E+LR+ PP  R  R C Q  T+         F KG I+ IP++A+H DP IWP+PEKF   RF  + K+    Y+ +PFG GPRNC+GMRFALLE K A+V IL+ + +  C ET   +  + +  + P   I LKI KR
Sbjct:   75 KTYGRLCGYYMGTRAAILVADPEMAKQILVKEFDKFVNRPIVQSAQTPPTDKTLLSLQDDDWRRLRHTITPTFSAVKLKQVLPLINESCRILVEKLGEACKDGKSVDVLRSYGKFTMETIVTTAFGIDCQTQTNPNDQFVPNAQRLFGGQSLFRMLAVLFPYLQPIVSLMVKQLGLGKQTETGK-SAMFIVDAARQIIKHRRETGSQGRKDLLEILLSA---ETTDDDGRRK----NKLSDDEIVAQCFTFILAGYETTSNTMAFTSYLLALNPDKQDRLIEEIDEVAATVGDNFDYDTVLGMEYLEMVVQEALRLYPPGFRFGRTCNQSCTINGQ-----FFPKGCIVLIPVFAMHRDPEIWPEPEKFQPERFTAEAKQARHPYAHLPFGGGPRNCIGMRFALLEAKMALVYILRYYRLERCPETEVPVQLQGTITISPKHGIYLKITKR 512          

Query:  275 YGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDR------MELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDT-PIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKL----GILFRKI-LPKWEFFGKESFQFFIDNMQMAIDERAKSTDK----------------YNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSERE-IANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            YG+L   Y G     +V D E+ +QI++KEF  F +R      + L+       K L  L+  DW R+R+ +TPTF++ K++++ PLIS+   +L +++     D   +D+   +   TM+ I  T FG+   +QTNPN+QF+ NA+R F     + F I+ ++FP L     ++ R++ L +    GK S  F +D  +  I  R ++  K                  D L +++ A   ET +D    K      LS+DEI+AQ   F+LAG++ T+ T+AF SY LA NPD Q  L  EI +   +  +    DT++ M  LD +V E+LR+ PP  R+ R C Q  T+         F KG ++ IP+YA+H DP IWP+PEKF   RF  + K+    Y+++PFG GPRNC+GMRFALL+VK A+V IL+++ +  C ET   L  +    + P   + L+I KR
Sbjct:   44 YGRLCGYYRGTRASILVADPEMAQQILVKEFDKFVNRGVSEGLLPLSSHIPPTDKNLISLQDDDWRRLRHFVTPTFSAVKIKQVVPLISESCRILVEQLGQACKDGKSVDVCRTYVKFTMETIVSTAFGIDCQTQTNPNDQFLSNAQRYFGKP--SPFTILAVLFPYLQPIISVMVRRLGLGRQTEIGK-SVMFIVDAARQIIKHRRETGSKGVKYLHFPQGEPSGPRKKDLLEILLSA---ETTDDDGKRK----NKLSDDEIVAQCFTFILAGFQNTSNTMAFTSYLLALNPDKQDRLIEEIDDVAATVGDNFDYDTVLGMEYLDMVVQEALRLYPPGFRLGRTCNQSCTINGQ-----FFPKGCLVMIPVYAIHRDPEIWPEPEKFQPERFTAEAKQARHPYAYLPFGEGPRNCIGMRFALLKVKMALVYILRHYRLERCPETEVPLQLQGFISMSPKHGMHLRITKR 499          

Query:  224 DVQKMG-FHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKD--WERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDT--PIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFF-GKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECL-----GSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKI 1591
            D+Q++G  H       Q+YGK++    G +P  VVGD E+LK +M+KEF+ F +R  L FR  R+  +  +    D  W+R+R+ +TPTFTSGKLR+M+P I +  + L  +I     DT   +DI  +F  +T++VI  T FG+  + Q NPNN F   AK +F      +F+ +FLM P   + F+     + F     + ++FID  +  + +R   T    DF+ LM+ A   +            S+ LS+ EI+AQS+ FLLAG+ET++  L+  +Y+LA NP+ Q+ L  EI          S  E+AND    +  LD +V E LR+ PP   ++R C Q   +       +    G  + IP Y++H DP  WP+P+KFD  RF    K++   + F+PFG GPRNC+GMRFAL EVK  +  IL  ++ V   +T   L       L P   I L+I
Sbjct:   58 DIQRLGGIHVAPVRLMQEYGKVFAWSVGRTPAIVVGDPEILKHVMVKEFQNFRNRF-LLFRDTRSEMLHGMFSATDDKWKRIRSTLTPTFTSGKLRQMNPKIRESCDTLMDKIGKVA-DTGESVDILGMFCQMTLEVILSTAFGIDSEVQKNPNNTFSDKAKEIFKSP---TFLRMFLMLPFASVFFKI----FRFLIHNNNMKYFIDLSKEILSKRHDKTFNRKDFVDLMLSAVNPD-----------GSRKLSDPEIIAQSVTFLLAGHETSSNALSATAYYLALNPEVQERLRLEIRMAAETNSDKSPHELAND----LEYLDCVVNEVLRLHPPVHTMNRECAQACVI-----NGITIPAGMDVTIPFYSLHHDPDAWPEPDKFDPERFRGPAKESRHPFQFIPFGAGPRNCIGMRFALNEVKLVLFQILSKYKFVRSPDTQVPLVLIPGATLIPRDGIYLRI 495          

Query:  266 RQKYGKLYPMYF-GGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRA-HKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFG-ALTMDVIARTMFGMQIDSQTNPNN-QFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAID-ERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIAN-DTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLG 1564
            R+KYG+LY M+  G  P  VV D E++K IM+KEF  F DR             M+T  K + W R+RN ++P F++ K++ M PLI+   ++L  +++             F   LTMD I +T FG+Q ++QTN ++  F    K L T +     V +  + P    +F K  P        +F+  ++  +M ++ +++   ++  D L LM+ A   E            SK LS+ E++AQSL+FL+AGYETT  TL+FV+Y LA NP+ Q+ L  EI      E E+ + DT+  +P LD ++ E+LR+ PP     R CTQD  ++        F+KG  I I  Y++H DP  W DPE+FD  RF  +  ++   YS++PFG GP NCVGMRFA +E+K A+V +L+ F  V   +T  +    +  LLG
Sbjct:   38 RKKYGRLYAMFLVGKKPCVVVADPEIVKHIMVKEFSSFRDRPSFVMEQPEPFDSMMTSAKYEKWHRIRNTLSPAFSAHKMKLMVPLINSSCDVLINKLTKVAESGESFFTHKFHQGLTMDTILKTAFGIQSEAQTNYDDPAFKAARKSLSTSTTRRVIVTLLFLMPFKNYIF-KAFPSLVI---GNFEGLLEMTKMIVEVKKSNLHNEAKDMLDLMLSAAANENT----------SKKLSDMEVLAQSLIFLIAGYETTNITLSFVAYSLATNPEVQEKLQREIDSVWTEEDEMPSYDTVHNLPYLDMVISETLRLYPPGFVASRECTQDCVIKGYR-----FRKGLPIFIDAYSMHHDPEFWTDPERFDPERFSSEANQSRDPYSYLPFGHGPHNCVGMRFAQMEMKLALVRVLKKFSYVATADTPASPPVVVRALLG 457          

Query:  224 DVQKMG-FHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMEL--AFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTP---------------------------IDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFF-GKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEI-----MECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKI 1591
            D+Q++G  H       Q+YGK++    G +P  VVGD E+LK +M+KEF+ F +R  +    RS+  H M +     +W+R+R+ +TPTFTSGKLR+M+P + +  + L  +I     DT                            +DI  +F  +++++I  T FG+    Q NPNN F   AK +F      +F+ +FLM P   +LF+     + F     + ++FID  +  + +R   T    DF+ LM+ A   +            S+ LS+ EI+AQS+ FLLAG+ET++ TL+  +Y+LA NP+ Q+ L  EI          S +E+AND    +  LD +V E LRI PPA  ++R C Q   +       +    G  + IPIY++H DP  WP+P+KFD  RF    K++   + F+PFG GPRNC+GMRFAL EVK  +  IL  ++ V   +T   L       L P   I L+I
Sbjct:   58 DIQRLGGIHVAPVRLMQEYGKVFAWSVGRTPAIVVGDPEILKHVMVKEFQNFRNRFVVFKDIRSEMRHGMFSA-TDDNWKRIRSTLTPTFTSGKLRQMTPKMRESCDTLMDKIGKVA-DTAYLVRGIKNYHFAKIGNFSKKCAIQGESVDILGMFSPMSLEIILSTAFGIDSQVQKNPNNTFSDKAKEIFKSP---TFLRMFLMLPFASVLFKI----FRFLIQNNNIKYFIDLSKEILSKRHDKTFNRKDFVDLMLSAVNPD-----------GSRKLSDPEIIAQSVTFLLAGHETSSNTLSATAYYLALNPEVQERLRLEIRMAAETNSEKSPQELAND----LEYLDCVVNEVLRIHPPAHTINRECAQACVI-----NGITIPAGMDVTIPIYSLHHDPDAWPEPDKFDPERFRGPAKESRHPFQFIPFGAGPRNCIGMRFALNEVKLVLFQILSKYKFVRSPDTQVPLVLIPGAALIPRDGIYLRI 520          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLI----SDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQ-MAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            + GF  FD+ CR+KYGK + +Y G  P+  + D   +K +++KE +  FT+R            +    +   W+R+R++++P+FTSG+L++M  ++    ++ +  +KK+      D P+++K+ FG  +MDV+  T F + IDS  NP++ FV N K++  F F N   ++   FP LG +  K+  +  FF   +F FF   +Q +  D +        DFL LM+ + K            +  K LS+ EI++Q+++F+ AGYETT+++L F++Y LA NP+  + L  EI     ++  I    L+ M  LD++V ESLR+ P A R++RV    V +       L   K  ++ +P + +  DP +WP+PEKF   RF  ++K+T   Y++MPFG GPRNC+GMRFAL+ +K A+V ILQ +    C+ET       I GL+ P  PI LK+V R 
Sbjct:   54 RKGFPIFDEECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFHLNGPMYDSVFNA-EDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLVNSMKKKADK---DEPLNLKDHFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLLVAFFPFLGPIMEKM--ELSFFPASAFDFFYSALQKIKSDHKNNKQKSRIDFLQLMIDSQKNNQNG-------LQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPIQYAPLLEMEYLDSVVNESLRLYPIAARLERVAKATVEV-----NGLVIPKDMVVMVPTWPIQRDPELWPEPEKFKPERFSKENKETFDPYTYMPFGAGPRNCIGMRFALVSMKLALVEILQQYSFSVCKETEIPFELDIQGLIAPKRPIFLKLVPRS 498          

Query:  269 QKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD-TPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKST--DKYNDFLALMMKA----------------HKKET-------ENDSESSKLMDS-------KTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            + +G++   Y G  P+ V+ D +LL+Q+M+K+F  F +RM L F +K     L  LK + W RVR+++TP+F++ K+++M PLI+   E+L K ++ +       DI   FG  TMDVIA   F  Q+DSQ  P++ FV +A+  FTFSFF   ++ F+ FP L     + +P       E   FFI N+Q  I +R +     +  DFL LM+ A                H  ET        +D ESS+  +S       K ++ DE++ Q+ +FLLAGYETT++TL F  Y LA +P+ Q  +  E+ +            +  +  +D +V E+LR+ PP  R  R   +D  +       +   KG  + IP   +H DP  W +PEKF   RF  + K +   + ++PFG GPRNCVGMR A LE+K A+  + ++F +V C ET   L  K S  LGP + I +KI KR+
Sbjct:   76 KTHGRVCGYYLGRKPVVVIADPDLLRQVMVKDFSSFPNRMTLRFATKPMVDCLLALKDERWRRVRSILTPSFSAAKMKEMVPLINTVTEVLMKNLTTHAESGQAFDIHRCFGFFTMDVIASVAFATQVDSQNKPDDPFVHHAQMFFTFSFFRPMMMFFIAFPSLMAPVARFIPNKR--RDEMSNFFIHNIQKIIKQREEQPPDQRRRDFLQLMLDARTAKECASLDQFDTSNHGDETLTNPKAASSDQESSRSEESALRRPQKKMMTEDEVVGQAFIFLLAGYETTSSTLGFTCYLLAVHPECQHKVQQEVDQFFSRHESPDYTNIQELKYMDMVVSETLRLYPPGFRFAREVEEDCVV-----NGVRLPKGATLEIPAGFLHYDPEYWSEPEKFIPERFTAEAKASRHPFVYLPFGSGPRNCVGMRLAQLEIKMALAHLFRSFSVVACSETKVPLELKSSSTLGPKNGIFVKITKRE 546          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLI----SDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEF--FGKESFQFFIDNMQM--AIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            + GF  FD+ CR+KYGK + +Y G  P+  + D   +K +++KE +  FT+R          +  +++ +   W+R+R++++P+FTSG+L++M  ++    ++ I+ +KK++     D P+++KE FG  +MDV+  T F + IDS  NP++ FV N K++  F F N   +    FP LG     IL K+EF  F      FF   ++   A  E  K   +  DFL LM+ + K            +  K LS+ EI++Q+++F+ AGYETT+++L F++Y LA NP+  + L  EI     ++  +    LM M  LD +V ESLR+ P A R++RV    V +       L   K  ++ +P + +H DP +WP+PEKF   RF  ++K T   Y++MPFG GPRNC+GMRFAL+ +K A+V ILQ ++   C+ET       + G L P  PI LK+  R 
Sbjct:   54 RKGFFNFDEECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFRLNGP-LYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLIQSMKKKVDK---DEPLEMKEYFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLG----PILEKFEFSLFPSSVMDFFFAALRKIKANHENNKQKSRI-DFLQLMIDSQKNNQNG-------LQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQYVPLMEMEYLDCVVNESLRLYPIAARLERVAKATVEV-----NGLVIPKDMVVMVPTWPLHRDPELWPEPEKFKPERFSKENKDTFDPYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSVCKETEVPFEMDVQGFLAPKRPIQLKLTPRS 498          

Query:  233 KMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLI----SDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEF--FGKESFQFFIDNMQM--AIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQ 1603
            + GF  FD+ CR+KYGK + +Y G  P+  + D   +K +++KE +  FT+R          +  +++ +   W+R+R++++P+FTSG+L++M  ++    ++ I+ +KK++     D P+++KE FG  +MDV+  T F + IDS  NP++ FV N K++  F F N   +    FP LG     IL K+EF  F      FF   ++   A  E  K   +  DFL LM+ + K            +  K LS+ EI++Q+++F+ AGYETT+++L F++Y LA NP+  + L  EI     ++  +    LM M  LD +V ESLR+ P A R++RV    V +       L   K  ++ +P + +H DP +WP+PEKF   RF  ++K T   Y++MPFG GPRNC+GMRFAL+ +K A+V ILQ ++   C+ET      K+ G L P  PI LK+  R 
Sbjct:   54 RKGFFNFDEECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFRLNGP-LYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLIQSMKKKVDK---DEPLEMKEYFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLG----PILEKFEFSLFPSSVMDFFFAALRKIKANHENNKQKSRI-DFLQLMIDSQKNNQNG-------LQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQYVPLMEMEYLDCVVNESLRLYPIAARLERVAKATVEV-----NGLVIPKDMVVMVPTWPLHRDPELWPEPEKFKPERFSKENKDTFDPYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSVCKETEFPFELKM-GFLAPKRPIQLKLTPRS 497          

Query:  230 QKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKE-FKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKRQH 1606
            Q  G   F++ C+ KYG ++ +Y G SP+ ++ D +++K +++KE +  FT+R  +          +  +K + W+R+R+ I+P FTSG+L+++ P ++   + L  ++     + PIDIK+     ++DV+    F ++ D   NPN+   + A +   F+ +   +II ++FP    L +    K+E   + S  FF D ++   D+         DFL +M+++   E+E   ++ K   SK L+  EI+ Q+  F+L GYETT+TTL+ + Y LA NPDA   L  EI   L  +  ++ D L  +  LD ++CESLR+ PPA  +DRVC + + +       L   +G ++ IP++ +H DP  W  P+ F   RF  +++     Y++MPFG+GPRNCVGMR+A+L +K  IV +LQN+ +  C++TL  + F       P+ PI LK V R+ 
Sbjct:   52 QMKGLFAFNRECQAKYGDVWGLYEGRSPLLMIADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMNLNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWP--MIIRMIFPLGARLLKHF--KFEIIPRSSVDFFCDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESE--VKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPDAMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQI-----NGLTIPEGTVVGIPVHLLHRDPRFWDSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWK--FQPLKPIKLKFVPRKR 498          

Query:   65 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKE FGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFS FNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALM KAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTK+CFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPD KKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLE LTFKISGLL PISPILLKIVKR
Sbjct:    1 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEFFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSLFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALM-KAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDRKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISGLLSPISPILLKIVKR 511          

Query:   65 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKR HKMLT L GKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP+TPIDIKE FGALTMDVIARTMFG+QIDSQTNP +QFVINAK+LFTFSFFNSFVIIFL+FPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREI NDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTK+CFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLE LTFKIS LLGPISPILLKIVKR
Sbjct:    1 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRDHKMLTDLNGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPNTPIDIKEFFGALTMDVIARTMFGLQIDSQTNPKSQFVINAKKLFTFSFFNSFVIIFLLFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIPNDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISVLLGPISPILLKIVKR 512          

Query:   65 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKXXXXXXXXXXXXXXXXDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYH---------------------RFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKE FGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFS FNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLAL MKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTK+CFKKGDIIAIPIYAVHSDPSIWPDPEKFDYH                     RFDPD KKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLE LTFKISGLL PISPILLKIVKR
Sbjct:    1 MIGLLLSYIFDIKFLLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEFFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSLFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLAL-MKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRLSDHLFIGPPISILEFDYILRFDPDRKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISGLLSPISPILLKIVKR 532          

Query:  236 MGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKR HKMLT L GKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPP+TPIDIKE FGALTMDVIARTMFG+QIDSQTNP +QFVINAK+LFTFSFFNSFVIIFL+FPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREI NDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTK+CFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLE LTFKIS LLGPISPILLKIVKR
Sbjct:    1 MGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRDHKMLTDLNGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPNTPIDIKEFFGALTMDVIARTMFGLQIDSQTNPKSQFVINAKKLFTFSFFNSFVIIFLLFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIPNDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISVLLGPISPILLKIVKR 455          

Query:  260 MCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEIFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSFFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLALMMKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKLCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYH---------------------RFDPDHKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLENLTFKISGLLGPISPILLKIVKR 1600
            MCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKE FGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFS FNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLAL MKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTK+CFKKGDIIAIPIYAVHSDPSIWPDPEKFDYH                     RFDPD KKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLE LTFKISGLL PISPILLKIVKR
Sbjct:    1 MCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPDTPIDIKEFFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSLFNSFVIIFLMFPKLGILFRKILPKWEFFGKESFQFFIDNMQMAIDERAKSTDKYNDFLAL-MKAHKKETENDSESSKLMDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIANDTLMTMPILDAIVCESLRICPPAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRLSDHLFIGPPISILEFDYILRFDPDRKKTNGQYSFMPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISGLLSPISPILLKIVKR 467