DRBM domain-containing protein

Overview
NameDRBM domain-containing protein
Smed IDSMED30004696
Length (bp)2622
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DRBM domain-containing protein (SMED30004696) t-SNE clustered cells

Violin plots show distribution of expression levels for DRBM domain-containing protein (SMED30004696) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DRBM domain-containing protein (SMED30004696) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DRBM domain-containing protein (SMED30004696) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30004696

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30004696h1SMcG0016184 SmedASXL_016666SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of DRBM domain-containing protein vs. TrEMBL
Match: A0A4E0REN8 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_002948 PE=4 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 2.627e-63
Identity = 180/558 (32.26%), Postives = 272/558 (48.75%), Query Frame = 2
Query:  725 MGYWGPLLRYGTYGVYTIYNS--NVCFKKNIQSEKGLKSNVKYRLQL-------------KHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSK-CGTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFPSMDGSLR------IDIKSTNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQMLLYLSAEFSQMNLSFEID-SCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYID------LETSIGAKDNSFLVRGLMWT--QSDSSIDFEDLSDSI----TPETFLSSDKLNQISSKTVITNQAD---------LEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLV-VMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNL 2263
            MG WGPLLRYGTYG     N    +      Q+  G  S V   ++              K P   P  I + RQAMIC LQ   +    +L  +E++ +  + +++ + L+QV  K     P +LFAK+++LP  ER YF  L +I          +D   R      ++       Y C+L IGD++I++  + +K++A+   AR AF++L +  +LVG+ R W  +DY+  C++    +VP LPPFL+DP E L KKD KI+  + NE FDV+NPK   DFWLY   L +      I  + +L  SAEFSQM ++F+++      SF C+ ++D      + G    E   QA    LV  L  +QP+V    A H +         LE   G  + + L+  LMW   + D +ID E L         PE+ +  D L+  S  +    Q+D         LE F+  YA S+LV+PLRL+ +++   +WP V    R  GL+  +    + D   +     L+CK+ P  +LK  L   + +  F LL+ GNL
Sbjct:  398 MGQWGPLLRYGTYGRLPSPNEIQQLGLGGKTQASFGSSSEVSNGIESRQTASSFAAPSSDKMPPPPPTFILLRRQAMICALQLSCRERGRELFLREKEGISGLKVDFVNELKQVVEKNINVKPVFLFAKLNNLPKCERSYF--LKNIQ--------ELDARSRGGQNPHLEPLDPAQMYACDLLIGDVLIAEACSTYKQQAQNCAARQAFKLLSQPCFLVGSVRRWELVDYLVLCLSSKADLVPKLPPFLSDPFESLSKKDRKIDCKNPNETFDVVNPKPPEDFWLYLADLPATALDDEIYWEKILSQSAEFSQMTVAFDVEVDTETGSFLCSALIDNHRYPPITGQNVSESQKQAVK-ELVKTLRQTQPVVG---AVHSKSGSRWNPERLEPLWGVPERA-LIDTLMWGKEERDLAIDIEQLEAHCDVPELPES-VQPDGLDPNSDHSTKGVQSDEDRYASPRHLENFVQAYAASALVTPLRLSSRTVPPRVWPLVRQIARNWGLLSCIENHFLAD---KINLCVLVCKRAPLPRLKRTLYERENYGCFTLLDRGNL 936          
BLAST of DRBM domain-containing protein vs. TrEMBL
Match: A0A4V6RGU6 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008349 PE=4 SV=1)

HSP 1 Score: 236.113 bits (601), Expect = 4.086e-61
Identity = 180/565 (31.86%), Postives = 268/565 (47.43%), Query Frame = 2
Query:  725 MGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQLKHPLDLPVRIRMP----------RQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKC-GTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFPSMDGSLRIDIK----------STNDFYG------CELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQM----LLYLSAEFSQMNLSFEID-SCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQS--DSSIDFEDLS---DSITPETFLSSDKLNQISSKTVITNQAD-------LEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSNL 2287
            MG WGPLLRYGTYG     +     K+   +  G  +N      L  P   P R +MP          RQAMIC LQ   +    +L  +E++    + +++ S LE+++ +     P YLF ++  LPA+ER Y+ S +S          S   ++R  I            T  FYG      C+L IGD++I++  + +K +A+   AR AFRV  +  +LVG+ R W   DY+  C++    +VP LPPFL+DP E L KKD  I     +ENF+V+NPK   + W++         + ++D QM    +L  SAEFSQM +SFE++ +  + +F C+ +LD      V    S+++A   A   L+  L  +QP+V L        I    S+    +  LV  LMW +   + +I  E L    D   P           ISS T +TN  D       L+ FL  YA SSLV+PLRL+R  +   +W  V       GL+          + RE  A  +CK+ P  +LK  L   + +   RLL++G+L +  L  L
Sbjct:  399 MGQWGPLLRYGTYGRLPSVSEIRFLKEQRPAFSGTCANSSSVDSLNSPPQSPSRSKMPPPPPTFILLRRQAMICALQLSCRDRARELFYREKENTSGLKLDFVSELERLSERSINIKPVYLFTRMRMLPASERTYYVSHNS----------STSANVRHQISRIRGFQGVYTKTEPFYGVDDMYLCDLLIGDVLIAEACSTFKVQAQLSAARQAFRVFSQPCFLVGSIRRWDESDYLVLCLSPKAEMVPQLPPFLSDPFESLSKKDRTIQP---DENFEVINPKPAEELWIFMANYP----LTALDEQMHWDRILAQSAEFSQMTISFEVEVNTENGTFVCSALLDNQRFPPVSS-SSVDKAQLEATRELLKSLRKTQPVVGL----QADCIKDSGSLMGVPDGVLVDTLMWGKEELELAIAIEQLEAHCDVPIPSEAEVGPGSKNISS-TPLTNPKDRFRSARRLDAFLQAYAASSLVTPLRLSRSVVPPNLWAEVRTMSSNWGLLCQVDFP---PNTREAAALFVCKRAPLPRLKRTLYDQENYGCLRLLDKGHLSSAALKRL 937          
BLAST of DRBM domain-containing protein vs. TrEMBL
Match: A0A419PHE6 (Uncharacterized protein (Fragment) OS=Clonorchis sinensis OX=79923 GN=CSKR_12661s PE=4 SV=1)

HSP 1 Score: 232.646 bits (592), Expect = 5.746e-60
Identity = 179/556 (32.19%), Postives = 267/556 (48.02%), Query Frame = 2
Query:  725 MGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQL-----------KHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKC-GTCPKYLFAKVSSLPATEREYFTSLD-SIHCSPPDSFPSMDGSLRIDIKS-----TNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQM----LLYLSAEFSQMNLSFEID-SCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQS--DSSIDFEDLS---DSITPETFLSSDKLNQISSKTVITNQAD-------LEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSNL 2287
            MG WGPLLRYGTYG     +     K+   +  G  +N      L           K P   P  I + RQAMIC LQ   +    +L  +E++    + +++ S LE+++ K     P YLF ++  LPA+ER Y+ S + S   +       + G   +  K+      +D Y C+L IGD++I++  + +K +A+   AR AFRV  +  +LVG+ R W   DY+  C++    +VP LPPFL+DP E L KKD  I     +ENF+V+NPK   + W++         + ++D QM    +L  SAEFSQM +SFE++ +  + +F C+ +LD      V    S+++A   A   L+  L  +QP+V L        I    S+    +  LV  LMW +   + +I  E L    D   P           ISS T ITN  D       L+ FL  YA SSLV+PLRL+R  +   +W  V       GL+          + RE  A  +CK+ P  +LK  L   + +   RLL++GNL +  L  L
Sbjct:  402 MGQWGPLLRYGTYGRLPSVSEIRFLKEQKPAFSGTCANSSSGDSLSSPPLSPSRSKKMPPPPPTFILLRRQAMICALQLSCRDRARELFYREKENTSGLKLDFVSELERLSEKSINIKPVYLFTRMRMLPASERTYYVSHNLSTSANVRHQVSRIRGFQGVYTKTEPFYGVDDMYLCDLLIGDVLIAEACSTFKVQAQLSAARQAFRVFSQPCFLVGSIRKWDESDYLVLCLSPKAEMVPQLPPFLSDPFESLSKKDRTIQS---DENFEVINPKPAEELWIFMANYP----LTALDEQMHWDRILAQSAEFSQMTISFEVEVNTENGTFVCSALLDNQRFPPVSS-SSVDKAQLEATRELLTSLRKTQPVVGL----QTDCIKDSGSLMGVPDGVLVDTLMWGKEELELAIAIEQLEAHCDVPIPSEAEVGPGSKNISS-TPITNPKDRFRSARRLDAFLQAYAASSLVTPLRLSRSVVPPNLWAEVRTMSSNWGLLCQVDFP---PNTREAAALFVCKRAPLPRLKRTLYDQENYGCLRLLDKGNLSSAALRRL 941          
BLAST of DRBM domain-containing protein vs. TrEMBL
Match: G7YEZ4 (Uncharacterized protein OS=Clonorchis sinensis OX=79923 GN=CLF_106339 PE=4 SV=1)

HSP 1 Score: 232.646 bits (592), Expect = 7.609e-60
Identity = 179/556 (32.19%), Postives = 267/556 (48.02%), Query Frame = 2
Query:  725 MGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQL-----------KHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKC-GTCPKYLFAKVSSLPATEREYFTSLD-SIHCSPPDSFPSMDGSLRIDIKS-----TNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQM----LLYLSAEFSQMNLSFEID-SCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQS--DSSIDFEDLS---DSITPETFLSSDKLNQISSKTVITNQAD-------LEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSNL 2287
            MG WGPLLRYGTYG     +     K+   +  G  +N      L           K P   P  I + RQAMIC LQ   +    +L  +E++    + +++ S LE+++ K     P YLF ++  LPA+ER Y+ S + S   +       + G   +  K+      +D Y C+L IGD++I++  + +K +A+   AR AFRV  +  +LVG+ R W   DY+  C++    +VP LPPFL+DP E L KKD  I     +ENF+V+NPK   + W++         + ++D QM    +L  SAEFSQM +SFE++ +  + +F C+ +LD      V    S+++A   A   L+  L  +QP+V L        I    S+    +  LV  LMW +   + +I  E L    D   P           ISS T ITN  D       L+ FL  YA SSLV+PLRL+R  +   +W  V       GL+          + RE  A  +CK+ P  +LK  L   + +   RLL++GNL +  L  L
Sbjct:  432 MGQWGPLLRYGTYGRLPSVSEIRFLKEQKPAFSGTCANSSSGDSLSSPPLSPSRSKKMPPPPPTFILLRRQAMICALQLSCRDRARELFYREKENTSGLKLDFVSELERLSEKSINIKPVYLFTRMRMLPASERTYYVSHNLSTSANVRHQVSRIRGFQGVYTKTEPFYGVDDMYLCDLLIGDVLIAEACSTFKVQAQLSAARQAFRVFSQPCFLVGSIRKWDESDYLVLCLSPKAEMVPQLPPFLSDPFESLSKKDRTIQS---DENFEVINPKPAEELWIFMANYP----LTALDEQMHWDRILAQSAEFSQMTISFEVEVNTENGTFVCSALLDNQRFPPVSS-SSVDKAQLEATRELLTSLRKTQPVVGL----QTDCIKDSGSLMGVPDGVLVDTLMWGKEELELAIAIEQLEAHCDVPIPSEAEVGPGSKNISS-TPITNPKDRFRSARRLDAFLQAYAASSLVTPLRLSRSVVPPNLWAEVRTMSSNWGLLCQVDFP---PNTREAAALFVCKRAPLPRLKRTLYDQENYGCLRLLDKGNLSSAALRRL 971          
BLAST of DRBM domain-containing protein vs. TrEMBL
Match: A0A074Z0K4 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=T265_15307 PE=4 SV=1)

HSP 1 Score: 229.18 bits (583), Expect = 7.991e-59
Identity = 176/556 (31.65%), Postives = 265/556 (47.66%), Query Frame = 2
Query:  725 MGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQL-----------KHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKC-GTCPKYLFAKVSSLPATEREYFTSLD-SIHCSPPDSFPSMDGSLRIDIKS-----TNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQM----LLYLSAEFSQMNLSFEIDSCWDE-SFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQS--DSSIDFEDLS---DSITPETFLSSDKLNQISSKTVITNQAD-------LEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSNL 2287
            MG WGPLLRYGTYG     +     K+   +  G  +       L           K P   P  I + RQAMIC LQ   +    +L  +E++    + +++ S LE+++ K     P YLF ++  LP++ER Y+ S + S   +       + G   +  K+      +D Y C+L IGD++I++  + +K +A+   AR AFRV  +  +LVG+ R W   DY+  C++    +VP LPPFL+DP E L KKD  I      ENF+V+NPK   + W++         + ++D QM    +L  SAEFSQM +SFE++   ++ +F C+ +LD      V    S+++A   A   L+  L  +QP+V L        I    S+    +  LV  LMW +   + +I  E L    D   P           +SS T ITN  D       L+ FL  YA SSLV+PLRL+R  +   +W  V       GL+          + RE  A  +CK+ P  +LK  L   + +   RLL++GNL +  L  L
Sbjct:  398 MGQWGPLLRYGTYGRLPSISEIRFLKEQTPAFSGTCATSSSGDSLSSSPLSPSRSKKMPPPPPTFILLRRQAMICALQLSCRDRARELFYREKENTSGLKLDFVSELERLSEKSINIKPVYLFTRMRMLPSSERTYYVSHNLSTSANARHQISRIRGFQGVYTKTEPFYGVDDMYLCDLLIGDVLIAEACSTFKVQAQLSAARQAFRVFSQPCFLVGSIRRWDESDYLVLCLSPKAEMVPQLPPFLSDPFESLSKKDRTIQS---EENFEVINPKPAEELWIFMANYP----LSALDEQMHWDRILAQSAEFSQMTISFEVEVNTEKGTFVCSALLDNQRFPPVSS-SSVDKAQLEATRELLTSLRKTQPVVGL----QADCIKDSGSLMGVPDGVLVDTLMWGKEELELAIAIEQLEAHCDVPIPSDAEVGPGSKNVSS-TPITNPKDRFRSARRLDAFLQAYAASSLVTPLRLSRSVVPPNLWAEVRTMSSNWGLLCQVDFP---PNTREAAALFVCKRAPLPRLKRTLYDQENYGCLRLLDKGNLSSAALRRL 937          
BLAST of DRBM domain-containing protein vs. Planmine SMEST
Match: SMESG000069809.1 (SMESG000069809.1)

HSP 1 Score: 1468.37 bits (3800), Expect = 0.000e+0
Identity = 721/733 (98.36%), Postives = 728/733 (99.32%), Query Frame = 2
Query:  269 ANESEKSNILNEEYAKNIYLDNHDFVDCDIDSPVNKKPKLGESLCYQQSSENVKKLIDDWISEYNKWYKITFENEGNLTKEIGSIANVWSEYSNNVCNQYYTDHNKYLSQNSVFQSSSYPSHFITNSIQQNVAIIPSPQTTKTQRIKQSRVLMGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQLKHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKCGTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFPSMDGSLRIDIKSTNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQMLLYLSAEFSQMNLSFEIDSCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQSDSSIDFEDLSDSITPETFLSSDKLNQISSKTVITNQADLEYFLNVYAQSSLVSPLRLNRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSNLNRFIGYDNIDQYQXXXXXXXXXXXXNLHVDSDTNFLPEMSSLYSDIIRNVQRDSIPGFDC 2467
            ANESEKSNILNEEYAKNIYLDNHDFVDCDIDSPVNKKPKLGESLCYQQSSENVKKLIDDWISEYNKWYKITFENEG +TKEIGSIANVWSEYSNNVCNQYYTDHNKYLSQNS FQSSSYPSHFITNSIQQNVAIIPSPQT KTQRIKQSRVLMGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQLKHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKCGTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFPSMDGSLRIDIKSTNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQMLLYLSAEFSQMNLSFEIDSCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQSD SIDFEDLSDSITPETFLS DKL+QISSKTVITN++DLEYFLN+YAQSSLVSPLRL+RKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLS+LNRFIGYDNIDQYQDDGDEHGGSGGDNLHVDSDTNFLPEMSSLYSDIIRNVQRDSIPGFDC
Sbjct:    7 ANESEKSNILNEEYAKNIYLDNHDFVDCDIDSPVNKKPKLGESLCYQQSSENVKKLIDDWISEYNKWYKITFENEGIVTKEIGSIANVWSEYSNNVCNQYYTDHNKYLSQNSFFQSSSYPSHFITNSIQQNVAIIPSPQTNKTQRIKQSRVLMGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVKYRLQLKHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNINYSSVLEQVTSKCGTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFPSMDGSLRIDIKSTNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRVLERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDEKINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQMLLYLSAEFSQMNLSFEIDSCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVDKLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQSDISIDFEDLSDSITPETFLSLDKLSQISSKTVITNESDLEYFLNIYAQSSLVSPLRLDRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHTQLKAKLLRDKEFRTFRLLNEGNLPAEYLSHLNRFIGYDNIDQYQDDGDEHGGSGGDNLHVDSDTNFLPEMSSLYSDIIRNVQRDSIPGFDC 739          
The following BLAST results are available for this feature:
BLAST of DRBM domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0REN82.627e-6332.26Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
A0A4V6RGU64.086e-6131.86Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A419PHE65.746e-6032.19Uncharacterized protein (Fragment) OS=Clonorchis s... [more]
G7YEZ47.609e-6032.19Uncharacterized protein OS=Clonorchis sinensis OX=... [more]
A0A074Z0K47.991e-5931.65Uncharacterized protein (Fragment) OS=Opisthorchis... [more]
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BLAST of DRBM domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DRBM domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000069809.10.000e+098.36SMESG000069809.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004696 ID=SMED30004696|Name=DRBM domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2622bp
AAAAATACTAAGCGATTAAAATTCGCCATTTAATATAATTAAAAATTATG
CTTTCAGCCCGAGGTCGGTTATCCTCCCGAGAATATTAGATTTCTTAAAA
AGTTATTTTTAAATCGAACAAAATATTATCTATAGCTAAAATTTAAAATT
CAAATATTCTACCAATTTTGCTCTAAGTAAAAGCAAATCAACGTTGATTC
CGGATATGTTTTGCTGATTGACGGTACAAGTTCAATATTTTCAGATGTTA
AATATTTCCGAAACAGATGCCAACGAAAGCGAGAAATCAAATATTTTAAA
TGAAGAATATGCTAAGAATATTTACTTAGATAATCATGATTTTGTTGATT
GTGATATTGACAGTCCAGTTAATAAAAAGCCAAAACTAGGAGAATCTTTG
TGTTATCAGCAGTCGAGCGAAAATGTCAAAAAGTTAATCGATGATTGGAT
ATCGGAATATAACAAATGGTATAAAATTACTTTTGAAAATGAAGGAAATT
TAACAAAGGAGATCGGTTCAATTGCCAATGTATGGAGTGAATATTCGAAT
AATGTCTGCAATCAATATTATACGGATCATAATAAATATTTGTCACAAAA
TAGTGTTTTCCAATCGTCAAGTTATCCTTCTCATTTCATTACCAATTCTA
TTCAACAGAATGTAGCAATTATCCCGTCGCCACAAACTACCAAGACACAG
AGAATCAAACAAAGTCGAGTATTAATGGGATATTGGGGTCCGTTGTTACG
CTACGGCACGTATGGAGTTTACACGATTTACAATAGTAATGTCTGTTTCA
AGAAAAATATCCAATCAGAGAAGGGCTTGAAAAGCAATGTAAAATATCGG
CTGCAGCTAAAACATCCGTTAGATCTCCCAGTGAGGATTAGGATGCCTCG
GCAAGCCATGATTTGCACTCTTCAGTCAAAGATGAAATATCATTTGCACG
ACCTGAGAAAGCAGGAGCGAGATCCGCTGCTGCACATGAATATAAACTAT
TCCAGTGTCCTTGAGCAGGTGACATCCAAATGCGGCACTTGCCCTAAATA
TCTGTTTGCAAAGGTGAGCAGCCTGCCTGCAACTGAGCGTGAATATTTCA
CAAGTCTCGATTCGATCCACTGCTCCCCTCCAGATTCATTTCCATCGATG
GACGGATCGCTGCGCATCGATATCAAATCCACCAATGATTTCTACGGCTG
CGAATTGTTCATAGGCGACATAATTATCTCCCAGGGATTCGCGATATGGA
AACGGAGAGCCAGAGAGATCTGTGCCAGAAATGCGTTCCGAGTGCTGGAG
CGCGAGAGTTATCTGGTTGGAGCTCCCCGCTATTGGCACGGCATCGATTA
CATGACCGCTTGCGTCACCGACAATCCCTCCGTTGTGCCTCTCTTGCCGC
CGTTTCTCACCGATCCCACCGAACCCCTCTATAAAAAGGATGAGAAAATC
AACGAATCAGATAGAAATGAGAACTTCGATGTTCTCAACCCGAAATCAAT
TCACGATTTCTGGCTCTACGCCACCACTCTCAAATCTATCGATCACATCA
AAAGTATTGATCCTCAAATGCTGCTCTATCTGTCAGCGGAATTCAGTCAA
ATGAATTTATCATTCGAGATCGATAGCTGTTGGGATGAGTCTTTCTCGTG
TACAATAATGCTGGACAAATCCCCAGCAATTAGAGTCGACGGATTGGGTA
GTTTAGAGCAAGCCTGTCAAGCAGCTGCTCTGGTATTGGTTGACAAGCTC
GTGGACAGCCAGCCGATTGTCACATTGTCCGAGGCCTATCACCAACAATA
TATCGATCTGGAAACCAGCATCGGTGCCAAGGATAACTCATTTCTAGTTC
GCGGTTTAATGTGGACCCAATCGGATAGCTCTATTGATTTTGAAGATCTT
TCAGATTCTATCACTCCGGAAACGTTTCTCTCATCGGACAAGTTGAATCA
AATCTCCAGCAAGACGGTAATTACCAATCAGGCGGATCTAGAATATTTTC
TCAATGTTTATGCGCAATCTTCATTAGTCAGTCCGTTGAGGTTGAATAGG
AAATCTCTATTGGAGGAGATATGGCCAGCAGTGCCGCATAAAGTGAGAAA
AAGCGGATTGGTAGTCATGACAAAGGCGGCGGTTGGTGATGGCGATGAGA
GGGAGGGGGAGGCGTTCCTCATCTGTAAGCAAGTGCCTCACACGCAATTG
AAAGCGAAATTGCTGAGAGATAAGGAGTTTAGGACATTTAGGTTATTGAA
TGAAGGTAATTTGCCCGCGGAATATTTATCTAATTTGAATCGGTTTATCG
GGTACGACAATATCGACCAATATCAGGATGATGGTGATGAACATGGTGGT
AGTGGTGGTGACAATTTACATGTGGATTCCGACACCAATTTCCTCCCAGA
AATGTCTTCTTTGTATTCAGATATTATCAGAAATGTCCAGAGAGATTCAA
TTCCAGGATTTGATTGTTGATATCGATTTGTCTGTTGTATGTGATGCGTG
TAAATTGTTGGTATCGTTGTTGTCATTTCAATACATTTTCTTGTCTTTTC
ACTCATCGTGTTACAGTTAGGATAGGTGTCCATCCTCCGGAGACCCCCCA
TTAATGTCCATCCCCAGTGACC
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protein sequence of SMED30004696-orf-1

>SMED30004696-orf-1 ID=SMED30004696-orf-1|Name=SMED30004696-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=100bp
GHWGWTLMGGLRRMDTYPNCNTMSEKTRKCIEMTTTIPTIYTHHIQQTNR
YQQSNPGIESLWTFLIISEYKEDISGRKLVSESTCKLSPPLPPCSSPSS*
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protein sequence of SMED30004696-orf-2

>SMED30004696-orf-2 ID=SMED30004696-orf-2|Name=SMED30004696-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=742bp
MLNISETDANESEKSNILNEEYAKNIYLDNHDFVDCDIDSPVNKKPKLGE
SLCYQQSSENVKKLIDDWISEYNKWYKITFENEGNLTKEIGSIANVWSEY
SNNVCNQYYTDHNKYLSQNSVFQSSSYPSHFITNSIQQNVAIIPSPQTTK
TQRIKQSRVLMGYWGPLLRYGTYGVYTIYNSNVCFKKNIQSEKGLKSNVK
YRLQLKHPLDLPVRIRMPRQAMICTLQSKMKYHLHDLRKQERDPLLHMNI
NYSSVLEQVTSKCGTCPKYLFAKVSSLPATEREYFTSLDSIHCSPPDSFP
SMDGSLRIDIKSTNDFYGCELFIGDIIISQGFAIWKRRAREICARNAFRV
LERESYLVGAPRYWHGIDYMTACVTDNPSVVPLLPPFLTDPTEPLYKKDE
KINESDRNENFDVLNPKSIHDFWLYATTLKSIDHIKSIDPQMLLYLSAEF
SQMNLSFEIDSCWDESFSCTIMLDKSPAIRVDGLGSLEQACQAAALVLVD
KLVDSQPIVTLSEAYHQQYIDLETSIGAKDNSFLVRGLMWTQSDSSIDFE
DLSDSITPETFLSSDKLNQISSKTVITNQADLEYFLNVYAQSSLVSPLRL
NRKSLLEEIWPAVPHKVRKSGLVVMTKAAVGDGDEREGEAFLICKQVPHT
QLKAKLLRDKEFRTFRLLNEGNLPAEYLSNLNRFIGYDNIDQYQDDGDEH
GGSGGDNLHVDSDTNFLPEMSSLYSDIIRNVQRDSIPGFDC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003723RNA binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002111X2 cell