Dual specificity tyrosine phosphorylation regulated kinase 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004648 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 513.072 bits (1320), Expect = 3.200e-173 Identity = 249/460 (54.13%), Postives = 326/460 (70.87%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ + + +K + I G +IS + P L+ Q+ N N
Sbjct: 73 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------TGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGN 516
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 515.383 bits (1326), Expect = 4.825e-173 Identity = 249/460 (54.13%), Postives = 326/460 (70.87%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ + + +K + I G +IS + P L+ Q+ N N
Sbjct: 146 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------TGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGN 589
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 479.559 bits (1233), Expect = 2.562e-159 Identity = 227/393 (57.76%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TPE A++ +LT +E+ EI +P+IYF+G NA+K +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS +P+YC+V + L G +RRG RGPP SK + LK D+ F++FL RC+ +P+ R+ P +A++HPWI +
Sbjct: 141 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALK-GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 478.404 bits (1230), Expect = 3.597e-159 Identity = 227/393 (57.76%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TPE A++ +LT +E+ EI +P+IYF+G NA+K +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS +P+YC+V + L G +RRG RGPP SK + LK D+ F++FL RC+ +P+ R+ P +A++HPWI +
Sbjct: 121 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALK-GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 506
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Match: DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094]) HSP 1 Score: 478.404 bits (1230), Expect = 3.597e-159 Identity = 227/393 (57.76%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TPE A++ +LT +E+ EI +P+IYF+G NA+K +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RSS KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS +P+YC+V + L G +RRG RGPP SK + LK D+ F++FL RC+ +P+ R+ P +A++HPWI +
Sbjct: 121 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV--LVGGRSRRGKKRGPPGSKDWGTALK-GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 506
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 473.396 bits (1217), Expect = 4.741e-159 Identity = 222/394 (56.35%), Postives = 297/394 (75.38%), Query Frame = 2
Query: 152 SFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
F PE A++ L E++EI + +++F+G +A+K +I G N G+DD+ GSY +V+DHIAYRYEV K+IGKGSFG+VIKA+D+K+ +YVALK+++++ RF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NLYELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+ I ELLG+P + L+ KR TF S P+YCT P S + L G+ ++RG RGPP S+ + LK N D F+DFL RC++ +P TR+ P +A+KH W+R ++
Sbjct: 65 GFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI----GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALK-NMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRL 451
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 473.396 bits (1217), Expect = 4.741e-159 Identity = 222/394 (56.35%), Postives = 297/394 (75.38%), Query Frame = 2
Query: 152 SFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
F PE A++ L E++EI + +++F+G +A+K +I G N G+DD+ GSY +V+DHIAYRYEV K+IGKGSFG+VIKA+D+K+ +YVALK+++++ RF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NLYELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+ I ELLG+P + L+ KR TF S P+YCT P S + L G+ ++RG RGPP S+ + LK N D F+DFL RC++ +P TR+ P +A+KH W+R ++
Sbjct: 65 GFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI----GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALK-NMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRL 451
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 473.396 bits (1217), Expect = 4.741e-159 Identity = 222/394 (56.35%), Postives = 297/394 (75.38%), Query Frame = 2
Query: 152 SFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
F PE A++ L E++EI + +++F+G +A+K +I G N G+DD+ GSY +V+DHIAYRYEV K+IGKGSFG+VIKA+D+K+ +YVALK+++++ RF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NLYELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+ I ELLG+P + L+ KR TF S P+YCT P S + L G+ ++RG RGPP S+ + LK N D F+DFL RC++ +P TR+ P +A+KH W+R ++
Sbjct: 65 GFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI----GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALK-NMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRL 451
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 473.781 bits (1218), Expect = 5.889e-159 Identity = 222/394 (56.35%), Postives = 297/394 (75.38%), Query Frame = 2
Query: 152 SFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
F PE A++ L E++EI + +++F+G +A+K +I G N G+DD+ GSY +V+DHIAYRYEV K+IGKGSFG+VIKA+D+K+ +YVALK+++++ RF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NLYELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+ I ELLG+P + L+ KR TF S P+YCT P S + L G+ ++RG RGPP S+ + LK N D F+DFL RC++ +P TR+ P +A+KH W+R ++
Sbjct: 65 GFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI----GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALK-NMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRL 451
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 473.781 bits (1218), Expect = 5.889e-159 Identity = 222/394 (56.35%), Postives = 297/394 (75.38%), Query Frame = 2
Query: 152 SFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
F PE A++ L E++EI + +++F+G +A+K +I G N G+DD+ GSY +V+DHIAYRYEV K+IGKGSFG+VIKA+D+K+ +YVALK+++++ RF RQA EEIRIL+HL++ D + NI+H+ ++F FRNH CITFELL+ NLYELIK+NKF+GFSL+LVRKFA S+L CLD L+KN++IHCDLKPEN+LL+ RS IKVIDFGSSC+++QR+YTYIQSRFYRAPEVILG KYG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+ I ELLG+P + L+ KR TF S P+YCT P S + L G+ ++RG RGPP S+ + LK N D F+DFL RC++ +P TR+ P +A+KH W+R ++
Sbjct: 65 GFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVI----GGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVV--LAGARSKRGKMRGPPASRSWSTALK-NMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLRRRL 451
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100406) HSP 1 Score: 468.774 bits (1205), Expect = 2.409e-152 Identity = 230/392 (58.67%), Postives = 298/392 (76.02%), Query Frame = 2
Query: 158 TPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+P+ + + LT +E++EI +PQIYF+G NA+K + +Y G N +D++QG+YIH+ +DH+AYRYE+ KIIGKGSFG+VIKAYD+K H +VALKI++++ RF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NLYELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++GH LFPGENESDQL+CI E+LG+P+ +L KR +FF+ P+YCTV ++ + L G +RRG RGPP SK + L D FL+F+ C+E + R+ P EA+KHPW+R ++
Sbjct: 210 SPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKK-RPGVY----GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTV--RTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRL 593
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100404) HSP 1 Score: 468.774 bits (1205), Expect = 2.409e-152 Identity = 230/392 (58.67%), Postives = 298/392 (76.02%), Query Frame = 2
Query: 158 TPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+P+ + + LT +E++EI +PQIYF+G NA+K + +Y G N +D++QG+YIH+ +DH+AYRYE+ KIIGKGSFG+VIKAYD+K H +VALKI++++ RF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NLYELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++GH LFPGENESDQL+CI E+LG+P+ +L KR +FF+ P+YCTV ++ + L G +RRG RGPP SK + L D FL+F+ C+E + R+ P EA+KHPW+R ++
Sbjct: 210 SPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKK-RPGVY----GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTV--RTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRL 593
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Match: Dyrk3 (gene:FBgn0027101 transcript:FBtr0100402) HSP 1 Score: 468.774 bits (1205), Expect = 2.409e-152 Identity = 230/392 (58.67%), Postives = 298/392 (76.02%), Query Frame = 2
Query: 158 TPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+P+ + + LT +E++EI +PQIYF+G NA+K + +Y G N +D++QG+YIH+ +DH+AYRYE+ KIIGKGSFG+VIKAYD+K H +VALKI++++ RF RQA EEIRIL HL+++DK + NI+H++++FTFRNH CITFELL+ NLYELIKKN F+GFSL LVRKFA S+LQCLDAL KN IIHCD+KPEN+LL+ RS IKVIDFGSSC+ENQR+YTYIQSRFYRAPEVILGGKYG IDMWS GCILAEL++GH LFPGENESDQL+CI E+LG+P+ +L KR +FF+ P+YCTV ++ + L G +RRG RGPP SK + L D FL+F+ C+E + R+ P EA+KHPW+R ++
Sbjct: 210 SPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKK-RPGVY----GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTV--RTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALD-GCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRL 593
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100447) HSP 1 Score: 364.385 bits (934), Expect = 8.850e-114 Identity = 187/394 (47.46%), Postives = 259/394 (65.74%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCK---TKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLK-LNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIR 1324
TP ++ + LT E E++ + ++++ GQ+A K Y K T N G+DDD G+Y I +DHIA+RYE+ ++IGKGSFG+VI+A D+K + +VA+KII++ RF QA E+ IL+ L++ D + N++H+ ++ FR H+CITFEL++ NLYELIKKN + GFS+ L+R+F SI++CL L K IIHCDLKPENILL+ SSIKVIDFGSSCY ++++YTYIQSRFYR+PEVILG +YG IDMWS GCILAEL TG PLFPGENE +QL+CI E+LG+P ++ +R+ FF+S P+ T K G +S G KS L+ D F+DFL RC+E +P R+ P+EA H +++
Sbjct: 127 MTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASK----NYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK---------------------GRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089289) HSP 1 Score: 364.385 bits (934), Expect = 8.850e-114 Identity = 187/394 (47.46%), Postives = 259/394 (65.74%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCK---TKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLK-LNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIR 1324
TP ++ + LT E E++ + ++++ GQ+A K Y K T N G+DDD G+Y I +DHIA+RYE+ ++IGKGSFG+VI+A D+K + +VA+KII++ RF QA E+ IL+ L++ D + N++H+ ++ FR H+CITFEL++ NLYELIKKN + GFS+ L+R+F SI++CL L K IIHCDLKPENILL+ SSIKVIDFGSSCY ++++YTYIQSRFYR+PEVILG +YG IDMWS GCILAEL TG PLFPGENE +QL+CI E+LG+P ++ +R+ FF+S P+ T K G +S G KS L+ D F+DFL RC+E +P R+ P+EA H +++
Sbjct: 127 MTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASK----NYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK---------------------GRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 502.286 bits (1292), Expect = 2.292e-168 Identity = 247/466 (53.00%), Postives = 327/466 (70.17%), Query Frame = 2
Query: 113 STINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
++I S + TPE A++ L++ E EI + +IYF+G NA+K + ++ G + DDDQGSYIH+ +DHIAYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ E+LG+PS ++L+ KR F +S P+YCTV P S + L G +RRG RGPP S+ + LK D FLDFL +C+E +P+ R+ P +A++HPW+R ++ + ++K I G +IS + P L+ Q+ N N
Sbjct: 127 TSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGY----DDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALK-GCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRL----------PKPPTEKTTVKRITEGTGAITSISKLPPPSGSATKLRTNLAQMTDANGN 575
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 501.13 bits (1289), Expect = 3.990e-168 Identity = 247/466 (53.00%), Postives = 327/466 (70.17%), Query Frame = 2
Query: 113 STINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
++I S + TPE A++ L++ E EI + +IYF+G NA+K + ++ G + DDDQGSYIH+ +DHIAYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ E+LG+PS ++L+ KR F +S P+YCTV P S + L G +RRG RGPP S+ + LK D FLDFL +C+E +P+ R+ P +A++HPW+R ++ + ++K I G +IS + P L+ Q+ N N
Sbjct: 117 TSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGY----DDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALK-GCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRL----------PKPPTEKTTVKRITEGTGAITSISKLPPPSGSATKLRTNLAQMTDANGN 565
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 500.745 bits (1288), Expect = 1.197e-167 Identity = 247/466 (53.00%), Postives = 327/466 (70.17%), Query Frame = 2
Query: 113 STINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
++I S + TPE A++ L++ E EI + +IYF+G NA+K + ++ G + DDDQGSYIH+ +DHIAYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCL++L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ E+LG+PS ++L+ KR F +S P+YCTV P S + L G +RRG RGPP S+ + LK D FLDFL +C+E +P+ R+ P +A++HPW+R ++ + ++K I G +IS + P L+ Q+ N N
Sbjct: 138 TSIKSTESKPKPAPLTPEQAMKQYMSKLSVFEHQEILSYTEIYFIGPNAKKRQGVVGGSNNGGY----DDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVV--LNGGRSRRGKLRGPPGSRDWVTALK-GCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWLRRRL----------PKPPTEKTTVKRITEGTGAITSISKLPPPSGSATKLRTNLAQMTDANGN 586
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 492.271 bits (1266), Expect = 1.480e-164 Identity = 230/389 (59.13%), Postives = 299/389 (76.86%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
TPE A++ +T EQ EI + +IYFLG NA+K + + G N G+DDDQG YIH+ +DH+AYRYE K+IGKGSFG+V K YD+K ++VALKI++++ RF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TG+PLFPGE+E DQL+C+ ELLG+P ++L+ KR F +S P+YCTV + +++ L GS +RRG RG P SK + LK D F+DFL +C++ +P+TR+ P +A++HPW+
Sbjct: 132 MTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAV----AGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTV--STLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALK-GCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWL 513
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Match: dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3 [Source:ZFIN;Acc:ZDB-GENE-080219-31]) HSP 1 Score: 492.271 bits (1266), Expect = 1.530e-164 Identity = 230/389 (59.13%), Postives = 299/389 (76.86%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
TPE A++ +T EQ EI + +IYFLG NA+K + + G N G+DDDQG YIH+ +DH+AYRYE K+IGKGSFG+V K YD+K ++VALKI++++ RF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TG+PLFPGE+E DQL+C+ ELLG+P ++L+ KR F +S P+YCTV + +++ L GS +RRG RG P SK + LK D F+DFL +C++ +P+TR+ P +A++HPW+
Sbjct: 133 MTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAV----AGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTV--STLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALK-GCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWL 514
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:100485120]) HSP 1 Score: 525.013 bits (1351), Expect = 1.362e-176 Identity = 251/439 (57.18%), Postives = 325/439 (74.03%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP 1447
I ++ S S TPE A++ LT E EI +P+IYFLG NA+K + +I G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILGG+YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR FF+S P+YCTV P S + L G +RRG RGPP S+ + LK D FLDFL +C+E +P+ R+ P +A++H W+R ++ + + +KI++ I G +IS + P
Sbjct: 170 ITKLKSSSLTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVI----GGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVV--LNGGRSRRGKLRGPPGSRDWVTALK-GCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLPKPP---------TGEKISTKRITESTGAITSISKLPP 592
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 478.789 bits (1231), Expect = 9.656e-160 Identity = 232/429 (54.08%), Postives = 310/429 (72.26%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEIN-DKKENSTQLSSDKINSNGIQSKNGKCVNISD 1438
TP+ A++ L+ +E EI F +IYF+G NA+K + ++ G + DDDQG Y + +DH+AYRYEV K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TG+PLFPGE+E DQL+C+ ELLG P ++L+ KR F NS P+YCTV P +++ L GS +RRG RG P SK + LK D F+DFL C+ +P R+ P +A++H WI ++ + + +K + ++SS + GI SK V +++
Sbjct: 100 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGY----DDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALK-GCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVAN 521
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 478.019 bits (1229), Expect = 1.449e-159 Identity = 232/429 (54.08%), Postives = 310/429 (72.26%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEIN-DKKENSTQLSSDKINSNGIQSKNGKCVNISD 1438
TP+ A++ L+ +E EI F +IYF+G NA+K + ++ G + DDDQG Y + +DH+AYRYEV K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TG+PLFPGE+E DQL+C+ ELLG P ++L+ KR F NS P+YCTV P +++ L GS +RRG RG P SK + LK D F+DFL C+ +P R+ P +A++H WI ++ + + +K + ++SS + GI SK V +++
Sbjct: 83 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGY----DDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALK-GCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVAN 504
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 478.789 bits (1231), Expect = 2.286e-159 Identity = 232/429 (54.08%), Postives = 310/429 (72.26%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEIN-DKKENSTQLSSDKINSNGIQSKNGKCVNISD 1438
TP+ A++ L+ +E EI F +IYF+G NA+K + ++ G + DDDQG Y + +DH+AYRYEV K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TG+PLFPGE+E DQL+C+ ELLG P ++L+ KR F NS P+YCTV P +++ L GS +RRG RG P SK + LK D F+DFL C+ +P R+ P +A++H WI ++ + + +K + ++SS + GI SK V +++
Sbjct: 122 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGY----DDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALK-GCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVAN 543
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 477.633 bits (1228), Expect = 2.670e-159 Identity = 232/429 (54.08%), Postives = 310/429 (72.26%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEIN-DKKENSTQLSSDKINSNGIQSKNGKCVNISD 1438
TP+ A++ L+ +E EI F +IYF+G NA+K + ++ G + DDDQG Y + +DH+AYRYEV K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +N+IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCIL EL+TG+PLFPGE+E DQL+C+ ELLG P ++L+ KR F NS P+YCTV P +++ L GS +RRG RG P SK + LK D F+DFL C+ +P R+ P +A++H WI ++ + + +K + ++SS + GI SK V +++
Sbjct: 93 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGY----DDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTV--LNGSRSRRGKMRGAPGSKDWVAALK-GCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVAN 514
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:MGI Symbol;Acc:MGI:1330301]) HSP 1 Score: 516.924 bits (1330), Expect = 6.222e-174 Identity = 240/401 (59.85%), Postives = 309/401 (77.06%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RSSIKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++
Sbjct: 144 MGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRL 537
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]) HSP 1 Score: 482.641 bits (1241), Expect = 9.961e-161 Identity = 228/389 (58.61%), Postives = 295/389 (75.84%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
TPE A++ +LT +E+ EI +P+IYF+G NA+K + +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RS+ KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS LP+YC+V + L G +RRG RGPP SK + LK G D+ F++FL RC++ +P+ R+ P +A++HPWI
Sbjct: 140 LTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVV--LLGGRSRRGKKRGPPGSKDWATALKGCG-DYLFIEFLKRCLQWDPSARLTPAQALRHPWI 521
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:MGI Symbol;Acc:MGI:1330292]) HSP 1 Score: 383.259 bits (983), Expect = 7.928e-122 Identity = 196/386 (50.78%), Postives = 263/386 (68.13%), Query Frame = 2
Query: 170 AIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLI--YCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
A++ + L+ +EQSEI + +++FLG A+KL + + KT FDD+ GSY+ +++DHIAYRYEV ++IGKGSFG+V K D+K + VALKII++ RF QA E++ILE L++ DK++ N+VH+ + F FRNH+CITFELL NLYEL+K N F GF+L +VR+F SIL+CL L +IIHCDLKPENI+L + ++KVIDFGSSCYE+Q+VYTYIQSRFYR+PEVILG Y + IDMWS GCI+AEL TG+PLFPGENE +QL+CI E+LG+P + R+ FF+S LPK +N++ RG R P SK + +K D FLDFL RC+ P+ R+ PE+A+KH WI
Sbjct: 156 ALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKT------SFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKN-------INNN----------RGGKRY-PDSKDLTMVVKT--YDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI 515
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 297.36 bits (760), Expect = 2.035e-89 Identity = 166/372 (44.62%), Postives = 213/372 (57.26%), Query Frame = 2
Query: 287 KTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPK-LTGSYTRR-----GTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSS 1378
K K N G+DDD YI + RYE+ +IGKGSFG+V+KAYD++ VA+KIIK+ F QA E+R+LE + Q+D E K IVH+ HF FRNH+C+ FELL+ NLY+L++ FRG SL L RK A + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G NE DQ+S I E+LGIP ML+ + +F LP ++ L K G TRR G G P + F D +LR +E P RI P A++H + R E + + S+
Sbjct: 83 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFER--LPGGGWTLRR--TKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 450
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 297.36 bits (760), Expect = 8.423e-89 Identity = 166/372 (44.62%), Postives = 213/372 (57.26%), Query Frame = 2
Query: 287 KTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPK-LTGSYTRR-----GTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSS 1378
K K N G+DDD YI + RYE+ +IGKGSFG+V+KAYD++ VA+KIIK+ F QA E+R+LE + Q+D E K IVH+ HF FRNH+C+ FELL+ NLY+L++ FRG SL L RK A + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G NE DQ+S I E+LGIP ML+ + +F LP ++ L K G TRR G G P + F D +LR +E P RI P A++H + R E + + S+
Sbjct: 143 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFER--LPGGGWTLRR--TKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 510
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5U4C9|DYRK2_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Mus musculus OX=10090 GN=Dyrk2 PE=2 SV=1) HSP 1 Score: 516.924 bits (1330), Expect = 4.353e-173 Identity = 240/401 (59.85%), Postives = 309/401 (77.06%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RSSIKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++
Sbjct: 144 MGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRL 537
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q92630|DYRK2_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3) HSP 1 Score: 515.383 bits (1326), Expect = 2.317e-172 Identity = 249/460 (54.13%), Postives = 326/460 (70.87%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ + + +K + I G +IS + P L+ Q+ N N
Sbjct: 146 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------TGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGN 589
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q5ZIU3|DYRK2_CHICK (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus OX=9031 GN=DYRK2 PE=2 SV=1) HSP 1 Score: 508.064 bits (1307), Expect = 1.077e-170 Identity = 248/458 (54.15%), Postives = 327/458 (71.40%), Query Frame = 2
Query: 137 RIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIPGET----LKNGTHQLNGINYN 1498
++ + TPE A++ LT E +EI + +IYFLG NA+K + +I G N G+DDDQGSYI + +DHIAYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFR+H+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCT+ S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ + + +K ++ I G +IS + P + L+ Q+ N N
Sbjct: 73 KVKASVMTPEQAMKQYMQKLTTFEHNEIFGYTEIYFLGPNAKKRQGVI----GGPNNCGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNNMNVIHMLENFTFRSHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSPKLLDSSKRAKNFVSSKGYPRYCTITTLSDGSII--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAIRMTPSQALRHPWLRRRLPK---------PPTGEKASAKRITESTGAITSISKLPPTSSSASKLRTNLAQMTDANGN 514
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q922Y0|DYRK3_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Mus musculus OX=10090 GN=Dyrk3 PE=1 SV=1) HSP 1 Score: 482.641 bits (1241), Expect = 6.968e-160 Identity = 228/389 (58.61%), Postives = 295/389 (75.84%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
TPE A++ +LT +E+ EI +P+IYF+G NA+K + +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RS+ KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS LP+YC+V + L G +RRG RGPP SK + LK G D+ F++FL RC++ +P+ R+ P +A++HPWI
Sbjct: 140 LTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVV--LLGGRSRRGKKRGPPGSKDWATALKGCG-DYLFIEFLKRCLQWDPSARLTPAQALRHPWI 521
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Match: sp|Q4V8A3|DYRK3_RAT (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Rattus norvegicus OX=10116 GN=Dyrk3 PE=2 SV=1) HSP 1 Score: 481.485 bits (1238), Expect = 1.894e-159 Identity = 231/416 (55.53%), Postives = 303/416 (72.84%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGI 1402
TPE A++ +LT +E+ EI +P+IYF+G NA+K + +I G N G+DD G+YIH+ DH+AYRYEV KIIGKGSFG+V + YD+K +YVALK+++++ RF RQAAEEIRILEHL++ DK N++H+ E FTFRNHVC+ FELL+ +LYELIKKNKF+GFS+ LVRKFA SILQ LDAL KN+IIHCDLKPENILL+H RS+ KVIDFGSSC+E Q++YTYIQSRFYRAPE+ILG +Y PID+WSFGCILAEL+TG PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS LP+YC+V + L G +RRG RGPP SK + LK D+ F++FL RC++ +P+ R+ P +A++HPWI K L++DK++ +
Sbjct: 140 LTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVI----GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVTTQTDGRVV--LLGGRSRRGKKRGPPGSKDWAAALK-GCDDYLFIEFLKRCLQWDPSARLTPAQALRHPWI---------SKSAPRPLTTDKVSGKRV 539
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Match: F6WIM3 (Dual specificity tyrosine phosphorylation regulated kinase 2 OS=Xenopus tropicalis OX=8364 GN=tsg101 PE=4 SV=2) HSP 1 Score: 525.013 bits (1351), Expect = 2.138e-173 Identity = 251/439 (57.18%), Postives = 325/439 (74.03%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP 1447
I ++ S S TPE A++ LT E EI +P+IYFLG NA+K + +I G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILGG+YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR FF+S P+YCTV P S + L G +RRG RGPP S+ + LK D FLDFL +C+E +P+ R+ P +A++H W+R ++ + + +KI++ I G +IS + P
Sbjct: 170 ITKLKSSSLTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVI----GGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVV--LNGGRSRRGKLRGPPGSRDWVTALK-GCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLPKPP---------TGEKISTKRITESTGAITSISKLPP 592
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Match: A0A3Q2PIW0 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Fundulus heteroclitus OX=8078 PE=4 SV=1) HSP 1 Score: 523.857 bits (1348), Expect = 2.718e-173 Identity = 248/433 (57.27%), Postives = 319/433 (73.67%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSN--GIQSKNGKCVNISDIIP 1447
TPE A++ L+ E E+ +P++YF+GQNA+K ++ G N G+DDDQGSYI + +DHIAYRYEV K+IGKGSFG+V+KA+D+K +VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ EHF FRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+CI ELLG+PS ++L KR F +S P+YCTV P +++ L G +RRG RGPP SK + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ K S + DK +S G + +G +IS + P
Sbjct: 136 MTPELAMKQFMSKLSSFEHHEVFNYPEVYFVGQNAKKRSGVL----GGANNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMLEHFNFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSPKLLDASKRAKNFVSSKGYPRYCTVTTKPDGTAV--LNGGRSRRGKTRGPPGSKDWSAALK-GCDDPAFLDFLKQCLEWDPVLRMTPSQALRHPWLRRRL-----PKPPSGTTTGDKTSSTKRGTTTTDGAITSISKLAP 556
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Match: A0A3Q2QQS6 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Fundulus heteroclitus OX=8078 PE=4 SV=1) HSP 1 Score: 522.316 bits (1344), Expect = 9.047e-173 Identity = 248/433 (57.27%), Postives = 319/433 (73.67%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSN--GIQSKNGKCVNISDIIP 1447
TPE A++ L+ E E+ +P++YF+GQNA+K ++ G N G+DDDQGSYI + +DHIAYRYEV K+IGKGSFG+V+KA+D+K +VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ EHF FRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+CI ELLG+PS ++L KR F +S P+YCTV P +++ L G +RRG RGPP SK + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ K S + DK +S G + +G +IS + P
Sbjct: 129 MTPELAMKQFMSKLSSFEHHEVFNYPEVYFVGQNAKKRSGVL----GGANNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSSMNVIHMLEHFNFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSPKLLDASKRAKNFVSSKGYPRYCTVTTKPDGTAV--LNGGRSRRGKTRGPPGSKDWSAALK-GCDDPAFLDFLKQCLEWDPVLRMTPSQALRHPWLRRRL-----PKPPSGTTTGDKTSSTKRGTTTTDGAITSISKLAP 549
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Match: A0A3Q2GQ47 (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 OS=Cyprinodon variegatus OX=28743 PE=4 SV=1) HSP 1 Score: 518.85 bits (1335), Expect = 2.002e-171 Identity = 251/446 (56.28%), Postives = 324/446 (72.65%), Query Frame = 2
Query: 110 QSTINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP 1447
+ + +S ++ IP TPE A++ L+ E E+ FP++YF+GQNA+K ++ G N G+DDDQGSYI + +DHIAYRYEV K+IGKGSFG+V+KA+D+K +VALK+++++ RF RQAAEEIRILEHL++ DKES N++H+ EHF FRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+ESDQL+CI ELLG+PS ++L KR F +S P+YCTV P +++ L G +RRG RGPP SK + LK D FLDFL +C+E +P R+ P +A++H W+R ++ K S + DK +S + +G ++S P
Sbjct: 120 KKSADSKMKPIP---MTPEMAMKQFMSKLSAFEHHEVFNFPEVYFVGQNAKKRSGVL----GGANNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTLTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKESNMNVIHMLEHFNFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDESDQLACIIELLGMPSPKVLDGAKRAKNFVSSKGYPRYCTVTTMPDGTTV--LNGGRSRRGKTRGPPGSKDWSAALK-GCDDPLFLDFLKQCLEWDPALRMTPSQALRHSWLRRRL-----PKPPSGTTAGDKPSSTKRGTTDGAITSLSKHAP 550
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Match: A0A1S3FKV2 (dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Dipodomys ordii OX=10020 GN=Dyrk2 PE=4 SV=1) HSP 1 Score: 518.85 bits (1335), Expect = 2.273e-171 Identity = 250/460 (54.35%), Postives = 328/460 (71.30%), Query Frame = 2
Query: 131 IERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
+ ++ + TPE A++ LT E EI +P+IYFLG NA+K + + T G N G+DDDQGSY+ + +DH+AYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK++ N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RSSIKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR +F +S P+YCTV S + L G +RRG RGPP+S+ + LK D FLDFL +C+E +P R+ P +A++HPW+R ++ + + +K + I G +IS + P L+ Q+ N N
Sbjct: 144 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICLTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKSFVSSKGYPRYCTVTTLSDGSVV--LNGGRSRRGKLRGPPESREWGNALK-GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------TGEKTSVKRIPESTGAITSISKLPPPSSSASKLRTNLAQMTDANGN 587
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:103042530]) HSP 1 Score: 505.753 bits (1301), Expect = 8.445e-170 Identity = 250/466 (53.65%), Postives = 324/466 (69.53%), Query Frame = 2
Query: 113 STINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIP----GETLKNGTHQLNGINYN 1498
++I S + TPE A++ L+ E EI +P+I+F+G NA+K ++ G + DDDQGSYIH+ +DHIAYRYEV K+IGKGSFG+V+KAYD+K H++VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLD+L KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E DQL+C+ ELLG+PS ++L KR F +S P+YCTV P + L G +RRG RGPP SK + LK D FLDFL +C+E +PT R+ P +A++HPW+R ++ + + +K I G +IS + P L+ Q+ N N
Sbjct: 125 TSIKSTDSKPKPAPLTPEQAMKQYLSKLSTFEHQEIFNYPEIFFVGPNAKKRPGVVGGSNNGGY----DDDQGSYIHVPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDSLHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIELLGMPSQKLLDSSKRAKNFISSKGYPRYCTVTSLPDGTV--ALNGGRSRRGKLRGPPGSKDWVTALK-GCDDPLFLDFLKQCLEWDPTLRMTPSQALRHPWLRRRLPKPP---------TGEKTTVKRITEGTGAITSISKLPPTSGSASKLRTNLAQMTDANGN 574
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 491.886 bits (1265), Expect = 1.627e-164 Identity = 231/405 (57.04%), Postives = 304/405 (75.06%), Query Frame = 2
Query: 119 INSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+ PI+ P E A++ LT EQ E+ + +I+F+G NA+K + + G N G+DDDQG YIH+ +DHIAYRYE K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL++++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TG+PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS P+YCTV +++ L GS +RRG RGPP SK + LK D F+DFL +C++ P+TR+ P A++HPW+ ++
Sbjct: 126 VTKPIK--PGGPLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAV----AGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTT--LSNGTLVLNGSRSRRGKMRGPPGSKEWVTALK-GCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRL 521
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 491.5 bits (1264), Expect = 2.216e-164 Identity = 231/405 (57.04%), Postives = 304/405 (75.06%), Query Frame = 2
Query: 119 INSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
+ PI+ P E A++ LT EQ E+ + +I+F+G NA+K + + G N G+DDDQG YIH+ +DHIAYRYE K+IGKGSFG+V K YD+K H+++ALK+++++ RF RQAAEEIRILEHL++ DK N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL++++IIHCDLKPENILL+ RS IKVIDFGSSC+++QRVYTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TG+PLFPGE+E DQL+C+ ELLG+P ++L+ KR F NS P+YCTV +++ L GS +RRG RGPP SK + LK D F+DFL +C++ P+TR+ P A++HPW+ ++
Sbjct: 118 VTKPIK--PGGPLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAV----AGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTT--LSNGTLVLNGSRSRRGKMRGPPGSKEWVTALK-GCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWLYKRL 513
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 399.438 bits (1025), Expect = 4.463e-128 Identity = 198/396 (50.00%), Postives = 278/396 (70.20%), Query Frame = 2
Query: 134 ERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
+R+P +P A+++ LT +EQ EI + +I++LG + +K++ C+ + N G+DD+ GSY+ +++DHIAYRYEV ++IGKGSFG+V+K D+K + VA+KII++ RF +QA E++IL+ +++ D++S N++H+ E+F FRNH+CI+FELL NLYELIKKN F+GFSL L+R+FA S+L+CL L + +IIHCDLKPENILL + +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TG+PLFPGE+E +Q++CI E++G+P + ++ R+ FF+S P +N NS K RR P SK + S LK N D FLDF+ RC+ +PT R+ P+E M+H WI
Sbjct: 127 QRLP---MSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEG---CQGSPQ-NSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNP------RNVTNSKGKK------RR------PNSKELASVLKTN--DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 495
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 399.438 bits (1025), Expect = 4.659e-128 Identity = 198/396 (50.00%), Postives = 278/396 (70.20%), Query Frame = 2
Query: 134 ERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
+R+P +P A+++ LT +EQ EI + +I++LG + +K++ C+ + N G+DD+ GSY+ +++DHIAYRYEV ++IGKGSFG+V+K D+K + VA+KII++ RF +QA E++IL+ +++ D++S N++H+ E+F FRNH+CI+FELL NLYELIKKN F+GFSL L+R+FA S+L+CL L + +IIHCDLKPENILL + +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TG+PLFPGE+E +Q++CI E++G+P + ++ R+ FF+S P +N NS K RR P SK + S LK N D FLDF+ RC+ +PT R+ P+E M+H WI
Sbjct: 135 QRLP---MSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIE---GCQGSPQ-NSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRDSCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNP------RNVTNSKGKK------RR------PNSKELASVLKTN--DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWI 503
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 486.108 bits (1250), Expect = 2.933e-163 Identity = 232/396 (58.59%), Postives = 297/396 (75.00%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIK-VIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHK 1330
S + +PE A+R L+M E EI + ++YF+G +A+K + + G N+GFDD+QGSYIH+ +DH+AYRYEV ++IGKGSFG+V+KAYD++ H+YVALK+++++ RF RQAAEEIRILEHL++ DKE+ N++H+ E F FRNH+C+TFELL+ NLYELIKKNKF+GFSL +VRKFA SIL CL+AL KN+IIHCDLKPENILLR RS IK +IDFGSSCYE+QRVYTYIQSRFYRAP GG+YGLPIDMWS GCILAEL+TG PL PGE+E DQL+C EL G P +L+ KR FF+S P+YCTV P + L G TRRG RGPP S+ + LK DH F+DFL +C++ +P TR+ P +A+KHPW+R +
Sbjct: 101 STAMSPEQAMRKYMHRLSMFEHHEIFNYHEVYFVGPSAKKRQATL----SGVNNNGFDDEQGSYIHVPHDHVAYRYEVLRVIGKGSFGQVVKAYDHRTHQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKENTMNVIHMLESFNFRNHICMTFELLSMNLYELIKKNKFQGFSLQVVRKFAHSILLCLNALHKNRIIHCDLKPENILLRQQGRSGIKIIIDFGSSCYEHQRVYTYIQSRFYRAP----GGRYGLPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELTGSPPARLLEQSKRARQFFSSLGHPRYCTVTTLPGGPVV--LNGGRTRRGKLRGPPSSRDWTTALK-GCDDHLFIDFLKKCLDWDPATRLTPSQALKHPWLRRR 485
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 481.1 bits (1237), Expect = 2.783e-161 Identity = 224/387 (57.88%), Postives = 288/387 (74.42%), Query Frame = 2
Query: 158 TPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPW 1318
+P+ A+R LT +E EI + +IYF+G NA+K ++ G N G+DD+QGSY+H+ +DH+AYRYEV K+IGKGSFG+V+KA+D+K +VALK+++++ RF RQAAEEIRILEHL++ D+E+ NI+H+ E FTFR HVC+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLD L +N+IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEV+LG +YG PIDMWS GCILAEL+TG PL PGE+E DQL+C ELLG+P +L KR F +S P+YC V + P + + L +RRG RGPP S+ + + L+ D LDFL C+E P+ R+ P +A++HPW
Sbjct: 95 SPDQAVRLYGQKLTAYEHQEIYNYAEIYFVGHNAKKRPGVV----GGASNCGYDDEQGSYVHVAHDHVAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRENSMNIIHLLESFTFRGHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILLKQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLGMPPQRLLAQGKRSRNFVSSRGHPRYCGVTEAPDGAVV--LNAGRSRRGKPRGPPGSRELPAALR-GCDDPLLLDFLRGCLEWEPSERLTPAQALRHPW 474
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 280.796 bits (717), Expect = 1.383e-82 Identity = 152/331 (45.92%), Postives = 203/331 (61.33%), Query Frame = 2
Query: 368 RYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQ--IIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFN--SDCLPKYCTVIKNPVNSSLPKLTGSYTRR---GTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQE 1339
RYE+ +IGKGSFG+V+KAYD++ +VA+KIIK+ F QA E+R+LE + ++D + K IVH+ HF FRNH+C+ FELL+ NLY+L++ FRG SL L RKFA + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G NE DQ++ I E+LG+P ML+ + +F SD TV K + K GS G G P + + +F D +LR ++ +P TRI P A++H + + E
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTDMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKARKYFERLSD---GSWTVKKTKDSKREYKTAGSRKLHDIIGVESGGPGGRRMGEAGHTVADYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDE 488
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007958.1 (pep scaffold:Pmarinus_7.0:GL476685:157443:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 240.35 bits (612), Expect = 7.605e-73 Identity = 129/327 (39.45%), Postives = 185/327 (56.57%), Query Frame = 2
Query: 344 IVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIR 1324
+ ++H+ YRYEV +++G+GSFG+V+K D+K +VA+K++ EI IL+ LQ + SK I+ + EHF+FR C+ FELLN NL +K +GF L +VR FAIS+L+ L+ L +IH DLKP NI + +K+ DFG SC++++ +T IQ+R YRAPEVIL Y P DMWS GC LAEL +G LFPG DQL I E+ G+P +M+++ + + FF I P + + RG R P S+ + L L TD F DF+ C++ +P R+ P AM H W+R
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVLNRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFF----------AITKPTHWDIN------NHRGLVR-VPGSRALP--LALRTTDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVR 307
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007952.1 (pep scaffold:Pmarinus_7.0:GL476685:157428:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007952.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 238.81 bits (608), Expect = 3.368e-72 Identity = 128/327 (39.14%), Postives = 187/327 (57.19%), Query Frame = 2
Query: 344 IVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIR 1324
+ ++H+ YRYEV +++G+GSFG+V+K D+K +VA+K++ EI IL+ LQ + SK I+ + EHF+FR C+ FELLN NL +K +GF L +VR FAIS+L+ L+ L +IH DLKP NI + +K+ DFG SC++++ +T IQ+R YRAPEVIL Y P DMWS GC LAEL +G LFPG DQL I E+ G+P +M+++ + + FF + + ++ +N L ++ GS R P L L TD F DF+ C++ +P R+ P AM H W+R
Sbjct: 2 VWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVLNRARFNESVHRREIEILKRLQTARESSK--IIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFACK---DFSSNVR--LNRGLVRVPGS-------RALP--------LALRTTDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVR 306
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 262.307 bits (669), Expect = 5.908e-76 Identity = 149/389 (38.30%), Postives = 222/389 (57.07%), Query Frame = 2
Query: 242 FLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAY----RYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHL-QQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNS---------------DCLPKYC---TVIKNPVNS-----SLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHE-FLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
F Q ++ KR++ ++G+ N+GFD+ YI VND + +Y V I+G+G+FG+V+K + +A+K++KS + Q+ E +ILE L Q+ D +K + + +Y+ F +NH+C+ FELL+NNLYEL+K+NKF G S+ L+R F IL L L+++++IHCDLKPENILL ++ +K+IDFGSSC E + VYTYIQSRFYRAPE+ILG Y IDMWS GCI+AEL G P+FPG +E +QL+ I + LG P M+ K F + ++C +++ P LP + +Y R P + + + + E + FL + LNP R P++AM HP+I
Sbjct: 322 FTYQTSKNPKRVLTKPSEGKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNY------RYPKSIQNSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFI 704
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 153.68 bits (387), Expect = 7.730e-42 Identity = 100/320 (31.25%), Postives = 161/320 (50.31%), Query Frame = 2
Query: 389 IGKGSFGEVIKAYDYKFHRYVALKIIKSDNR--FTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKK----NKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTY---IQSRFYRAPEVILGGK-YGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPW 1318
+G G++ V K + YVALK +K D+ A EI +++ L+ NIV +Y+ N + + FE ++N+L + + N RG L LV+ F +LQ L +N+I+H DLKP+N+L+ R +K+ DFG + V T+ + + +YRAP+V++G + Y ID+WS GCILAE++TG PLFPG N+ +QL IF+++G P+ + + LPKY I+ L ++ +T+ D +DFL ++LNP R+ ++A+ HPW
Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK---------LPKYNPNIQQRPPRDLRQVLQPHTKE-------------------PLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 134.806 bits (338), Expect = 9.215e-35 Identity = 102/342 (29.82%), Postives = 162/342 (47.37%), Query Frame = 2
Query: 359 IAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIK--SDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYE-----HFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVL---VRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFG-SSCYENQR---------VYTYIQSRFYRAPEVILG-GKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
I +Y++ +IG+G++G V A VA+K I+ S F + EI++L + +++ NI+ I + N V + EL+ +L ++I N+ GFS + V+ F IL+ L ++ Q+IH D+KP N+LL + +KV DFG + C + + Y+ +R+YRAPE++L +Y +D+WS GCILAE+V+G PLFPG + QL I E+LG PS E K K Y R P + + S LN + +D L + ++ NP RI EA++HP++
Sbjct: 9 IPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDKVRPVSIDKLNAVYLVEELMETDLQKVIN-NQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLN--SNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKR--------------------------AKEYIANLPMRPPLPWETVWSKTDLNP---DMIDLLDKMLQFNPDKRISAAEALRHPYL 313
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 139.813 bits (351), Expect = 1.448e-34 Identity = 79/270 (29.26%), Postives = 136/270 (50.37%), Query Frame = 2
Query: 320 DDQGSYIHIVNDHIAY--RYEVCKIIGKGSFGEVIKAYDYKFH-RYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILL------------------------------RHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIP 1030
D G Y++ ND R+ V ++G+G+FG+V+K D K+ YVA+K+I++ +R+ A E+RIL+ + D + + + + E F ++NH+C+ +L ++Y+ + N F ++ A +++ + L IIH DLKPENIL+ + + IK+IDFGS+ + + I +R YRAPE++LG + P D+WS C+L ELV G L+P + ++ + + G P
Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTP 563
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 124.02 bits (310), Expect = 1.343e-30 Identity = 95/326 (29.14%), Postives = 157/326 (48.16%), Query Frame = 2
Query: 359 IAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIK---SDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHF-TFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGG-KYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGP-PQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPW 1318
I RY +G G+FG V A D + VA+K I S ++ E+++L+HL+ N++ + + F + + EL +L+ L++ R V+ F IL+ L + +IH DLKP NIL+ +K+ DFG + ++ ++ Y+ +R+YRAPE++L KY + +D+WS GCI AE++ G PLFPG++ Q S I +LLG P +++ +NT K+ T SLP R P P S+ K+ + + +D L + + +P RI +A+ HP+
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHE------NLICLQDIFLSPLEDIYFVTELQGTDLHRLLQT---RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN--ENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTL-------KFVT--------SLPH-----------RDPIPFSERFKT------VEPDAVDLLEKMLVFDPKKRITAADALAHPY 301
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 494.582 bits (1272), Expect = 2.154e-166 Identity = 238/395 (60.25%), Postives = 299/395 (75.70%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHK 1330
S SFT E A++ L+ +E EI + QIYF+G+ A+K + ++ G N G+DD+QGSYIH+ DHIAYRYEV KIIGKGSFG+V+KA D+K + +VALK+++++ RF RQA EEIRILEHL++ DK++ NI+H+ EHFTFRNHVC+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSCYE+QR+YTYIQSRFYRAPEVILG +YG+PIDMWSFGCILAEL+TG+PLFPGE+E DQL+C ELLG ++ + KR F NS P+YCT+ P S ++G +RRG RG P SK LK D F+DFL RC+E +P+ R+ P +A++HPW+R +
Sbjct: 96 SRSFTAEVAMKQYMHKLSGYETHEIFNYSQIYFVGEAAKKRQGVV----GGANNCGYDDEQGSYIHVPKDHIAYRYEVLKIIGKGSFGQVVKALDHKTNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKDNTHNIIHMLEHFTFRNHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRAKNFINSKGYPRYCTITTLPDGSV--AVSGGRSRRGKTRGAPNSKTFVQALK-GCDDAMFIDFLKRCLEWDPSARMTPSQALRHPWLRRR 483
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 390.963 bits (1003), Expect = 1.904e-129 Identity = 195/360 (54.17%), Postives = 264/360 (73.33%), Query Frame = 2
Query: 188 DNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIE 1267
D +T EQSEI +P+++FLG +A+K+ + N+ +DDD GSY+ ++DH+AYRYEV +++GKGSFG+V+KA D+K ++VA+KII++ RF +QA E++IL++L++ DK++ N++H+ EHF FRNH+CITFEL+ NLYELIKKN F+GFSL L+R+FA ++L CL + K +IIHCDLKPENILLR ++SIKVIDFGSSCYE+QRVYTYIQSRFYR+PEVILG Y + IDMWSFGCILAEL TG+PLFPGENE +QL+CI E+LG+PS ++++ R+ FF+S +P+ T NS K RR P S+ I + LK N D FLDFL +C+E
Sbjct: 3 DRITTFEQSEILDYPEVWFLGLDAKKIDGV----PGAPQNNNYDDDNGSYLKALHDHLAYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKDNTHNLIHMIEHFYFRNHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILLRQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASRRRLFFDSKGIPRCIT------NSKGKK------RR------PSSRDISAALKTN--DALFLDFLKQCLE 338
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 276.174 bits (705), Expect = 3.275e-84 Identity = 159/373 (42.63%), Postives = 221/373 (59.25%), Query Frame = 2
Query: 287 KTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDAL--EKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPK---YCTVIKNPVNSSL-PKLTGSYTRRGTFRGPPQSK-------GIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENST 1366
K ++NDG+DD+ YI + RYE+ +IGKGSFG+V KAYD++ ++A+KIIK+ F QA E+++LE + + D + K IV + HF +RNH+C+ FELL+ NLY+L++ FRG SL L RKFA + L L + IIHCDLKPENILL + RS+IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y L IDMWS GCIL E+ TG PLF G NE DQ+ I E+LG+P ++L + + FF D LP C +K+ V L P + G G P + ++ YLK F D +LR ++ + TRI P A+ H + + +E + ++T
Sbjct: 51 KRPPQYNDGYDDENYDYIVKAGEKWFDRYEIESLIGKGSFGQVCKAYDHQEKEHIAVKIIKNKKPFLNQAQIEVKLLELMNKNDPDGKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLCSPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFF--DRLPDGSYQCLKVKDGVKEYLSPGSRKLHDILGCETGGPGGRRLGEAGHTLQDYLK-------FKDLILRMLDYDRKTRIVPYAALHHCFFKKTAEEGTNTTHSAT 414
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 193.356 bits (490), Expect = 8.820e-55 Identity = 114/331 (34.44%), Postives = 178/331 (53.78%), Query Frame = 2
Query: 377 VCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSS--IKVIDFGSSCYENQRV-YTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSS-----LPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTD--------HEFLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
V + +G+G+FG+V+K + + VA+KI+K + RQ EI IL L + E+ N V E F +NH C+ FE+L NLY+ +K++KF L +R +L L L +IH DLKPENI+L ++ +KVIDFGS+ + ++ V TY+QSR+YRAPEVILG + IDMWS GC++AEL G PL+PG +E DQ+ I + G+P +L + + + FF + + V++ + ++ K+ R+ F + L G + +EF+ L R + ++ RI PEEA+ H ++
Sbjct: 1 VLEFLGRGTFGQVVKCWKKGTNELVAIKILKDHPSYARQGQIEISILAKLSAENSEAY-NFVRAIECFQHKNHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIMLVDPDKQPFRVKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQGLPYDHLLNNATKTSRFFKK-AINTHTGVLEWKLKNANEHERETKIPSKEARKYIFNSLDDIAQVNLSSSLTGNERIAEKIDRYEFVSLLKRMLTIDQEKRITPEEALSHQFV 329
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 176.022 bits (445), Expect = 1.081e-47 Identity = 108/370 (29.19%), Postives = 188/370 (50.81%), Query Frame = 2
Query: 278 IYCKTKGE---FNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILL-----------------RHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLG-IPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHE-FLDFLLRCIELNPTTRIKPEEAMKHPWI 1321
IY ++ E ++ DD+ G I+ D + RYEV ++G+G+FG+V++ YD K VA+K+IK+ ++ A EI++LE + Q ++ K + + + F H+C+ FE + ++++ +K N + + L VR + ++ + L + ++ H DLKPEN+L R++ S +++IDFGS+ +E++ T + +R YRAPEVIL + P D+WS GCI+ EL TG LF + L+ + ++G IPS + K ++ F+ K + +G Y R K +K Y+ + H+ F + L +E +P RI +EAM+HP+
Sbjct: 91 IYTRSHAEERCYSTSRDDEDGHLIYHKGDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDVVAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSLCIKMLDWFNHHGHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPS-DFAKKSRKTKYFY------------KGKLEWDEKSSSGKYVRENC-------KPLKKYMLSDSEGHQLFFNLLDYLLEYDPEKRITAKEAMQHPFF 440
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Match: dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:101170635]) HSP 1 Score: 501.901 bits (1291), Expect = 2.306e-168 Identity = 242/440 (55.00%), Postives = 318/440 (72.27%), Query Frame = 2
Query: 113 STINSPIERIP-SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDK-INSNGIQSKNGKCV 1426
+T N P + P ++ T E A++ ++ E E+ F ++YF+G +A+K ++ G N G+DDDQGSYI + +DHIAYRYEV K+IGKGSFG+V+KA+D+K +VALK+++++ RF RQAAEEIRILEHL++ DK+S N++H+ E+FTFRNH+C+TFELL+ NLYELIKKNKF+GFSL LVRKFA SILQCLDAL KN+IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YG+PIDMWS GCILAEL+TG+PL PGE+E+DQL+CI ELLG+PS ++L KR F +S P+YCTV ++ L G +RRG RGPP SK + LK D FLDFL +C+E +P R+ P +A++H W+R ++ + + SS K ++G + N K V
Sbjct: 110 ATSNKPADSKPKTNPLTAEQAMKQFMSKMSSFEHHEVFSFSEVYFIGPSAKKRSGVL----GGPNNGGYDDDQGSYIQVPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSSMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRAKNFVSSKGYPRYCTVTT--LSDGTTVLNGGRSRRGKVRGPPGSKVWSTALK-GCDDPLFLDFLKQCLEWDPAHRMTPSQALRHSWLRRRLPKPPTGTTPGDKTSSSKRATTDGTITSNSKLV 542
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 489.574 bits (1259), Expect = 4.580e-164 Identity = 229/393 (58.27%), Postives = 297/393 (75.57%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TP+ A+R L+ E SEI +P +YF+G NA+K + G N G+DD+QG YIH+ +DH+AYRYE KIIGKGSFG+V K YD+K +++ALK+++++ RF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TG+PLFPGE+ESDQL+C ELLG+P L++L+ KR F NS P+YC P +++ LTGS +RRG RGPP SK LK D F+DF+ +C++ +P +R+ P +A++HPW+ ++
Sbjct: 92 LTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAV----AGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALK-GCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRL 477
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 490.345 bits (1261), Expect = 1.458e-163 Identity = 229/393 (58.27%), Postives = 297/393 (75.57%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TP+ A+R L+ E SEI +P +YF+G NA+K + G N G+DD+QG YIH+ +DH+AYRYE KIIGKGSFG+V K YD+K +++ALK+++++ RF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TG+PLFPGE+ESDQL+C ELLG+P L++L+ KR F NS P+YC P +++ LTGS +RRG RGPP SK LK D F+DF+ +C++ +P +R+ P +A++HPW+ ++
Sbjct: 150 LTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAV----AGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALK-GCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRL 535
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 490.345 bits (1261), Expect = 1.458e-163 Identity = 229/393 (58.27%), Postives = 297/393 (75.57%), Query Frame = 2
Query: 155 FTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKI 1333
TP+ A+R L+ E SEI +P +YF+G NA+K + G N G+DD+QG YIH+ +DH+AYRYE KIIGKGSFG+V K YD+K +++ALK+++++ RF RQA EEIRILEHL + D+ N+VH+ E+FTFRNH+C+TFELL+ NLYELIK+NKF+GFSL LVRKFA SILQCL+AL +++IIHCDLKPENILL+ RS IKVIDFGSSC+E+QRVYTYIQSRFYRAPEVILG +YGLPIDMWSFGCILAEL+TG+PLFPGE+ESDQL+C ELLG+P L++L+ KR F NS P+YC P +++ LTGS +RRG RGPP SK LK D F+DF+ +C++ +P +R+ P +A++HPW+ ++
Sbjct: 150 LTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAV----AGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRNGTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATV--LTGSRSRRGKMRGPPASKDWNVALK-GCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWLYRRL 535
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 394.045 bits (1011), Expect = 2.401e-126 Identity = 204/435 (46.90%), Postives = 285/435 (65.52%), Query Frame = 2
Query: 134 ERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWI-RHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNIS 1435
+R+P +P A+ N + LT EQ EI + +++FLG +QK I N G+DD+ GSYI +++DHIAYR+EV ++IGKGSFG+V+K D+K + VA+K+I++ RF QA E++ILE +++ DK++ N++H+ E+F FRNH+CI+FELL NLYELIKKN F+GFSL L+R+FA ++L+CL L K +IIHCDLKPENILL +IKV+DFGSSCYE QRVYTYIQSRFYR+PEVILG Y + IDMWS GCILAEL TG+PLFPGE+E +Q++CI E+LG+P + ++ R+ FF+S P +N NS K RR P SK + + LK TD FL+F+ C+ +PT R+ P+E ++H WI + + + + + +SD S Q+ N K +S
Sbjct: 128 QRLP---MSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQK----IEGSQGAPHNSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNLHNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNP------RNITNSKGKK------RR------PNSKELSAALKT--TDPLFLEFIKGCLTWDPTKRMTPDEGLQHQWILEGNFNRVRSRAKTTVKKTSDTSTSADRQA-NSKSEKVS 534
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076583.1 (SMESG000076583.1) HSP 1 Score: 972.23 bits (2512), Expect = 0.000e+0 Identity = 470/473 (99.37%), Postives = 472/473 (99.79%), Query Frame = 2
Query: 107 MQSTINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIPGETLKNGTHQLNGINYNQTIFTNISQ 1525
MQSTINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKT+GEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNL+ELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKN VNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIPGETLKNGTHQLNGINYNQTIFTNISQ
Sbjct: 1 MQSTINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTEGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNSVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHKIQEINDKKENSTQLSSDKINSNGIQSKNGKCVNISDIIPGETLKNGTHQLNGINYNQTIFTNISQ 473
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 489.96 bits (1260), Expect = 3.772e-164 Identity = 235/395 (59.49%), Postives = 295/395 (74.68%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHK 1330
S +P+ A+R LT +E EI +P I+F+G NA+K ++ G N G+DDDQ SYIH+ +DHIAYRYEV K++GKGSFG+V+KA D+K VA+K+++++ RFTRQAAEEIR+LE L++ D +S CN++HI + F FRNHVC+TFELL+ NLYELIKKNKF+GFSL LVRKFA SIL CL+ L +N+IIHCDLKPENILL+ RS IKVIDFGSSC E+QR+YTYIQSRFYRAPEVILGGKYG+PIDMWSFGCILAEL TG+P+FPGE+E DQL+CI E+LG P ++ CKR FF S P+YC + S + L G ++RG FRGPP SK + + LK N D FLDF LRC+ P TR+ P+EA+KHPW+R K
Sbjct: 147 STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVL----GGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVI--LKGGRSKRGRFRGPPASKTLSTALK-NCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 534
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 489.189 bits (1258), Expect = 5.917e-164 Identity = 235/395 (59.49%), Postives = 295/395 (74.68%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIYCKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTGHPLFPGENESDQLSCIFELLGIPSLEMLKDCKRKNTFFNSDCLPKYCTVIKNPVNSSLPKLTGSYTRRGTFRGPPQSKGIKSYLKLNGTDHEFLDFLLRCIELNPTTRIKPEEAMKHPWIRHK 1330
S +P+ A+R LT +E EI +P I+F+G NA+K ++ G N G+DDDQ SYIH+ +DHIAYRYEV K++GKGSFG+V+KA D+K VA+K+++++ RFTRQAAEEIR+LE L++ D +S CN++HI + F FRNHVC+TFELL+ NLYELIKKNKF+GFSL LVRKFA SIL CL+ L +N+IIHCDLKPENILL+ RS IKVIDFGSSC E+QR+YTYIQSRFYRAPEVILGGKYG+PIDMWSFGCILAEL TG+P+FPGE+E DQL+CI E+LG P ++ CKR FF S P+YC + S + L G ++RG FRGPP SK + + LK N D FLDF LRC+ P TR+ P+EA+KHPW+R K
Sbjct: 144 STCLSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVL----GGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPDSNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVI--LKGGRSKRGRFRGPPASKTLSTALK-NCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLRRK 531
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076586.1 (SMESG000076586.1) HSP 1 Score: 464.922 bits (1195), Expect = 3.518e-158 Identity = 223/280 (79.64%), Postives = 247/280 (88.21%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIY--------CKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 961
S+ P A++ + +T+ EQ EI +PQ+Y+LGQNAQK +RL C EFN+GFDD+QGSYIH+++DHIAYRYEV K+IGKGSFG+V+KAYD+K YVALKI++++ RFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNL+ELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG
Sbjct: 19 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 298
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Match: SMESG000076586.1 (SMESG000076586.1) HSP 1 Score: 464.537 bits (1194), Expect = 4.167e-158 Identity = 223/280 (79.64%), Postives = 247/280 (88.21%), Query Frame = 2
Query: 146 SDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNAQKLKRLIY--------CKTKGEFNDGFDDDQGSYIHIVNDHIAYRYEVCKIIGKGSFGEVIKAYDYKFHRYVALKIIKSDNRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLYELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 961
S+ P A++ + +T+ EQ EI +PQ+Y+LGQNAQK +RL C EFN+GFDD+QGSYIH+++DHIAYRYEV K+IGKGSFG+V+KAYD+K YVALKI++++ RFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNL+ELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG
Sbjct: 18 SEPLNPRLAMKYFMNKITLFEQHEIFYYPQVYYLGQNAQKSRRLTQQKNNYPESCSNLEEFNNGFDDEQGSYIHVLSDHIAYRYEVVKLIGKGSFGQVVKAYDHKLGNYVALKIVRNEKRFTRQAAEEIRILEHLQQYDKESKCNIVHIYEHFTFRNHVCITFELLNNNLFELIKKNKFRGFSLVLVRKFAISILQCLDALEKNQIIHCDLKPENILLRHMNRSSIKVIDFGSSCYENQRVYTYIQSRFYRAPEVILGGKYGLPIDMWSFGCILAELVTG 297 The following BLAST results are available for this feature:
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity tyrosine phosphorylation regulated kinase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004648 ID=SMED30004648|Name=Dual specificity tyrosine phosphorylation regulated kinase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2602bpback to top protein sequence of SMED30004648-orf-1 >SMED30004648-orf-1 ID=SMED30004648-orf-1|Name=SMED30004648-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=474bp MQSTINSPIERIPSDSFTPEYAIRNLFDNLTMHEQSEIRKFPQIYFLGQNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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