Mothers against decapentaplegic homolog

Overview


Name	Mothers against decapentaplegic homolog
Smed ID	SMED30004641
Length (bp)	1324

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Mothers against decapentaplegic homolog (SMED30004641) t-SNE clustered cells

Violin plots show distribution of expression levels for Mothers against decapentaplegic homolog (SMED30004641) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mothers against decapentaplegic homolog (SMED30004641) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mothers against decapentaplegic homolog (SMED30004641) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30004641

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30004641	h1SMcG0020761	dd_Smed_v4_8193_0_2	dd_Smed_v4	PMID:27063937 Scimone et al., 2016
epidermis	SMED30004641	h1SMcG0020761	dd_Smed_v4_8193_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30004641	h1SMcG0020761	dd_Smed_v4_8193_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
Match: SMAD3 (SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769])

HSP 1 Score: 253.062 bits (645), Expect = 8.606e-82
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:   31 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 230

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
Match: SMAD3 (SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769])

HSP 1 Score: 253.062 bits (645), Expect = 1.788e-80
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  121 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 320

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
Match: SMAD3 (SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769])

HSP 1 Score: 251.521 bits (641), Expect = 4.048e-79
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  182 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 381

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
Match: SMAD2 (SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768])

HSP 1 Score: 252.677 bits (644), Expect = 6.121e-79
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  244 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 437

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Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  244 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 437

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
Match: sma-2 (Dwarfin sma-2 [Source:UniProtKB/Swiss-Prot;Acc:Q02330])

HSP 1 Score: 197.208 bits (500), Expect = 2.913e-58
Identity = 91/186 (48.92%), Postives = 128/186 (68.82%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIK--GELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRL 1279
            W TV+YYELN+RVG+    ++  +TIDG+T P  + S+ SLG  +NV+R+A IE TR+ IG G K  Y++  G LF +C SD+AIFVQS   N  +G+H  TV+KI  KC++K+F+ + F+++L     RGF+A F L  +  IR+SFVKGWGA Y RQ +T+TPCW+E+HL+ PL  LD  L  +
Sbjct:  222 WATVSYYELNTRVGEQVKVSSTTITIDGFTDPCINGSKISLGLFSNVNRNATIENTRRHIGNGVKLTYVRSNGSLFAQCESDSAIFVQSSNCNYINGFHSTTVVKIANKCSLKIFDMEIFRQLLEDCSRRGFDASFDLQKMTFIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVLSTM 407

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Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIK--GELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRL 1279
            W TV+YYELN+RVG+    ++  +TIDG+T P  + S+ SLG  +NV+R+A IE TR+ IG G K  Y++  G LF +C SD+AIFVQS   N  +G+H  TV+KI  KC++K+F+ + F+++L     RGF+A F L  +  IR+SFVKGWGA Y RQ +T+TPCW+E+HL+ PL  LD  L  +
Sbjct:  222 WATVSYYELNTRVGEQVKVSSTTITIDGFTDPCINGSKISLGLFSNVNRNATIENTRRHIGNGVKLTYVRSNGSLFAQCESDSAIFVQSSNCNYINGFHSTTVVKIANKCSLKIFDMEIFRQLLEDCSRRGFDASFDLQKMTFIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVLSTM 407

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
Match: sma-3 (Dwarfin sma-3 [Source:UniProtKB/Swiss-Prot;Acc:P45896])

HSP 1 Score: 148.288 bits (373), Expect = 3.469e-40
Identity = 90/266 (33.83%), Postives = 133/266 (50.00%), Query Frame = 2

Query:  500 FICINPRHYLISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFC-----EWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECL--SDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQR 1276
            +ICINP HY      +  S P  L++ +        P T+               +     E+  ++   Q          W  +TY+ELNSRVG+ F      +T+DGYT+PS  ++R  LG LTNV+R+  IE TR  IGKG +    + ++ +     SD  +FVQS  +N+        V +IPP   + VF    F ++L Q      + +  L+  C IRISFVKGWG  Y RQ +T+TPCW+E+ LN PL  +D  +++
Sbjct:  122 YICINPYHY------QRLSRPQGLNSSMPSPQPISSPNTIWQSSGSSTASCASSPSPSVFSEDGGEVQVHQRPPPFRHPKSWAQITYFELNSRVGEVFKLVNLSITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKEDQMHIMITNNSDMPVFVQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNLFFQMLEQ-SCNDSDGLNELSKHCFIRISFVKGWGEDYPRQDVTSTPCWLELRLNVPLAYIDQKMKQ 380

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
Match: daf-8 (Dwarfin sma [Source:UniProtKB/TrEMBL;Acc:Q21733])

HSP 1 Score: 146.362 bits (368), Expect = 1.875e-38
Identity = 72/198 (36.36%), Postives = 112/198 (56.57%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHS---SRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W  + YYE  + +G+          IDG+T+    S   SRFSLG   N +RS      R  IGKG +FY + GE+++E L +  +FVQS  +N+ +G+   TV K+PP   +KVF+ + F + L     + ++ V+ L+ +C++R+SF KGWG  Y R T+  +P W + HLN P+  +D+ L  +  P   CSSR+
Sbjct:  349 WLKLIYYEEGTMIGEKADVEGHHCLIDGFTASRTDSETRSRFSLGWYNNPNRSPQTAEVRGLIGKGVRFYLLAGEVYVENLCNIPVFVQSIGANMKNGFQLNTVSKLPPTGTMKVFDMRLFSKQLRTAAEKTYQDVYCLSRMCTVRVSFCKGWGEHYRRSTVLRSPVWFQAHLNNPMHWVDSVLTCMGAPPRICSSRT 546

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
Match: daf-14 (Smad protein [Source:UniProtKB/TrEMBL;Acc:G5EEP2])

HSP 1 Score: 105.531 bits (262), Expect = 1.963e-25
Identity = 71/209 (33.97%), Postives = 101/209 (48.33%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRI-LHQHELRGFEAVFALTPLC-------------SIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W T+ YYEL  R+G AF +  P +TIDG T  S    R SL    + SR++   + R  +G G +  Y  GEL+L  L+D  +FVQ P  N T        +  P K   ++ N+ D KR+ +   E    E   AL PL              +IR+SF KG+G +YSR  +   PCW+E+ L++P    D    R+     +  SRS
Sbjct:   90 WCTIFYYELTVRLGKAFEAKVPTITIDGATGAS-DECRMSLTSQPS-SRNSKSSQIRNTVGAGIQLAYENGELWLTVLTDQIVFVQCPFLNQT--------LNKPLKYVFRLQNKGDQKRMKIFDKEQFEQEKTLALGPLTEKEVADERMRIFSNIRVSFCKGFGETYSRLKVVNLPCWIEIILHEPADEYDTVF-RINNERPEIGSRS 287

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Match: Smox (gene:FBgn0025800 transcript:FBtr0340159)

HSP 1 Score: 254.603 bits (649), Expect = 2.184e-79
Identity = 119/241 (49.38%), Postives = 170/241 (70.54%), Query Frame = 2

Query:  593 NSSVRPPT-LTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            N+   PP  ++ DG  ++    ++ + L    +A+ +   +  F  W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKG + YYI GE+F ECLSD++IFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:  249 NTGTPPPGYMSEDGDPIDPNDNMNMSRLTPPADAAPVMYHEPAF--WCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 486

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Match: Smox (gene:FBgn0025800 transcript:FBtr0071192)

HSP 1 Score: 254.603 bits (649), Expect = 2.184e-79
Identity = 119/241 (49.38%), Postives = 170/241 (70.54%), Query Frame = 2

Query:  593 NSSVRPPT-LTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            N+   PP  ++ DG  ++    ++ + L    +A+ +   +  F  W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKG + YYI GE+F ECLSD++IFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:  249 NTGTPPPGYMSEDGDPIDPNDNMNMSRLTPPADAAPVMYHEPAF--WCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 486

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Match: Mad (gene:FBgn0011648 transcript:FBtr0077616)

HSP 1 Score: 232.646 bits (592), Expect = 2.357e-71
Identity = 124/298 (41.61%), Postives = 184/298 (61.74%), Query Frame = 2

Query:  431 LKHHHSASGSILNPVSAELSNENFICINPRHYLISISAKSFSSPTNLSA---LLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKA-IENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            L+ +H A  S+  P +   SN  F       + +S S  S  SP+++++      +  +   PP  +P     ++       LL A + + +Q++  +  F  W ++ YYELN RVG+ F      V +DG+T+PS +S R  LG L+NV+R++ IE TR+ IGKG   YY+ GE++ ECLSD+AIFVQS   N   G+HP+TV KIPP C++K+FN ++F ++L Q    GFEAV+ LT +C+IR+SFVKGWGA Y RQ +T+TPCW+E+HL+ PL+ LD  L ++ +P N  SS S
Sbjct:  167 LQFNHVAEPSM--PHNVSYSNSGF-----NSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAF--WASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS 455

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Match: Mad (gene:FBgn0011648 transcript:FBtr0332372)

HSP 1 Score: 233.032 bits (593), Expect = 1.062e-70
Identity = 124/298 (41.61%), Postives = 184/298 (61.74%), Query Frame = 2

Query:  431 LKHHHSASGSILNPVSAELSNENFICINPRHYLISISAKSFSSPTNLSA---LLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKA-IENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            L+ +H A  S+  P +   SN  F       + +S S  S  SP+++++      +  +   PP  +P     ++       LL A + + +Q++  +  F  W ++ YYELN RVG+ F      V +DG+T+PS +S R  LG L+NV+R++ IE TR+ IGKG   YY+ GE++ ECLSD+AIFVQS   N   G+HP+TV KIPP C++K+FN ++F ++L Q    GFEAV+ LT +C+IR+SFVKGWGA Y RQ +T+TPCW+E+HL+ PL+ LD  L ++ +P N  SS S
Sbjct:  237 LQFNHVAEPSM--PHNVSYSNSGF-----NSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAF--WASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS 525

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Match: Med (gene:FBgn0011655 transcript:FBtr0085816)

HSP 1 Score: 137.887 bits (346), Expect = 8.949e-35
Identity = 83/218 (38.07%), Postives = 117/218 (53.67%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAF--ASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKF-YYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVI-KIPPKCNIKVFNEKDFKRILH----------------------QHELRGFEAVFA--------LTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRL 1279
            W ++ Y+EL+++VG+ F   SA P V IDGY  PS   +RF LG L+NV R+   ER R  IGKG +     +G+++L CLSDN++FVQS   +  +G  P   + KI P   IKVF+ +   + +H                      Q    G  ++ A        L  LC +R+SFVKGWG  Y RQ+I  TPCW+EVHL++ L+ LD  L  +
Sbjct:  472 WCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPS-GGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAM 688

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Zebrafish
Match: smad3a (SMAD family member 3a [Source:ZFIN;Acc:ZDB-GENE-000509-3])

HSP 1 Score: 252.292 bits (643), Expect = 4.765e-79
Identity = 140/328 (42.68%), Postives = 194/328 (59.15%), Query Frame = 2

Query:  395 VFHNKSNAESDALKHHHSASGSILNPVSAELSNENFICINPRHYLIS-----ISAKSFSSPTN-LSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSI-------------FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
             FH K +       H+      +L PV           + PRH  I      +   S S P N +    +E  S+  P T  P G    D  T D  + ++++  S   +   +             +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  111 AFHMKKDEVCVNPYHYQRVETPVLPPV-----------LVPRHTEIPSEFPPLDDYSHSIPENTIFPAGIEPQSNYIPET-PPPGYISEDGETSDHQMNRSMDTGSPNLSPNPVSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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Query:  395 VFHNKSNAESDALKHHHSASGSILNPVSAELSNENFICINPRHYLIS-----ISAKSFSSPTN-LSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSI-------------FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
             FH K +       H+      +L PV           + PRH  I      +   S S P N +    +E  S+  P T  P G    D  T D  + ++++  S   +   +             +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  111 AFHMKKDEVCVNPYHYQRVETPVLPPV-----------LVPRHTEIPSEFPPLDDYSHSIPENTIFPAGIEPQSNYIPET-PPPGYISEDGETSDHQMNRSMDTGSPNLSPNPVSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Zebrafish
Match: smad2 (SMAD family member 2 [Source:NCBI gene;Acc:30639])

HSP 1 Score: 252.677 bits (644), Expect = 1.038e-78
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  275 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 468

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Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  275 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 468

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Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  275 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 468

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Match: rgs19 (regulator of G-protein signaling 19 [Source:Xenbase;Acc:XB-GENE-5736048])

HSP 1 Score: 254.988 bits (650), Expect = 1.651e-80
Identity = 116/201 (57.71%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSDNAIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  181 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVEMTRRHIGRGVRLYYIGGEVFAECLSDNAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 380

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Match: rgs19 (regulator of G-protein signaling 19 [Source:Xenbase;Acc:XB-GENE-5736048])

HSP 1 Score: 254.988 bits (650), Expect = 5.192e-80
Identity = 116/201 (57.71%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSDNAIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVEMTRRHIGRGVRLYYIGGEVFAECLSDNAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Match: rgs19 (regulator of G-protein signaling 19 [Source:Xenbase;Acc:XB-GENE-5736048])

HSP 1 Score: 255.373 bits (651), Expect = 5.331e-80
Identity = 116/201 (57.71%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSDNAIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  230 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVEMTRRHIGRGVRLYYIGGEVFAECLSDNAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 429

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Match: rgs19 (regulator of G-protein signaling 19 [Source:Xenbase;Acc:XB-GENE-5736048])

HSP 1 Score: 255.373 bits (651), Expect = 6.440e-80
Identity = 116/201 (57.71%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSDNAIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  236 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVEMTRRHIGRGVRLYYIGGEVFAECLSDNAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 435

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Match: eif3m (eukaryotic translation initiation factor 3 subunit M [Source:Xenbase;Acc:XB-GENE-968605])

HSP 1 Score: 252.677 bits (644), Expect = 9.542e-80
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  178 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 371

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
Match: Smad2 (SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051])

HSP 1 Score: 252.677 bits (644), Expect = 4.202e-79
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  244 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 437

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
Match: Smad3 (SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674])

HSP 1 Score: 252.292 bits (643), Expect = 4.620e-79
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
Match: Smad2 (SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051])

HSP 1 Score: 253.062 bits (645), Expect = 7.915e-79
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  274 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467

[Close]

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  274 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
Match: Smad5 (SMAD family member 5 [Source:MGI Symbol;Acc:MGI:1328787])

HSP 1 Score: 228.024 bits (580), Expect = 2.741e-69
Identity = 103/195 (52.82%), Postives = 144/195 (73.85%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN+RVG+AF +++  V +DG+T PS + SRF LG L+NV+R++ IE TR+ IGKG   YY+ GE++ ECLSD++IFVQS   N   G+HP TV KIP  C++K+FN ++F ++L Q    GFEAV+ LT +C+IR+SFVKGWGA Y RQ +T+TPCW+E+HL+ PL+ LD  L ++ +P N  SS S
Sbjct:  271 WCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465

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BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Match: sp|P84025|SMAD3_RAT (Mothers against decapentaplegic homolog 3 OS=Rattus norvegicus OX=10116 GN=Smad3 PE=1 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 3.231e-78
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

[Close]

BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Match: sp|P84024|SMAD3_PIG (Mothers against decapentaplegic homolog 3 OS=Sus scrofa OX=9823 GN=SMAD3 PE=2 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 3.231e-78
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Match: sp|Q8BUN5|SMAD3_MOUSE (Mothers against decapentaplegic homolog 3 OS=Mus musculus OX=10090 GN=Smad3 PE=1 SV=2)

HSP 1 Score: 252.292 bits (643), Expect = 3.231e-78
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Match: sp|P84022|SMAD3_HUMAN (Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 3.231e-78
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  226 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Match: sp|P84023|SMAD3_CHICK (Mothers against decapentaplegic homolog 3 OS=Gallus gallus OX=9031 GN=SMAD3 PE=2 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 3.432e-78
Identity = 115/201 (57.21%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  227 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 426

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BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Match: V9ILI5 (Mothers against decapentaplegic 3 OS=Apis cerana OX=7461 GN=ACCB14854 PE=2 SV=1)

HSP 1 Score: 253.447 bits (646), Expect = 2.956e-79
Identity = 114/202 (56.44%), Postives = 156/202 (77.23%), Query Frame = 2

Query:  716 IFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            ++CE   W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKGA+ YYI GE+F ECLSD++IFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA+Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:    1 MYCEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNTVVEQTRRHIGKGARLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAAYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 201

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BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Match: E9G7J0 (Mothers against decapentaplegic homolog OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_314805 PE=3 SV=1)

HSP 1 Score: 260.381 bits (664), Expect = 3.257e-79
Identity = 133/287 (46.34%), Postives = 183/287 (63.76%), Query Frame = 2

Query:  503 ICINPRHY-----------LISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLAT---VDCNLLKAIENASQIATDQSIFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +C+NP HY           L+   A++  S  NLSA     N  +   T  P G    D  T    D   +  +  +  I     ++CE   W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKG + YYI GE+F ECLSD++IFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:  116 VCVNPYHYQRVETPVLPPILVPRQAETGVSSVNLSAPGTNNNHQIVTKT-PPPGYMSEDGDTQEPADLMNVSRVSPSPPIDAQPVMYCEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNPVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 400

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BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Match: S4NSR1 (Smad on X OS=Pararge aegeria OX=116150 PE=4 SV=1)

HSP 1 Score: 256.529 bits (654), Expect = 3.467e-79
Identity = 128/259 (49.42%), Postives = 177/259 (68.34%), Query Frame = 2

Query:  560 PTNLSALLMEKNSSVRPPT-LTPDGKRL--NDLATVDCNLLKAIENASQIATDQS--IFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            P N +  L   +    PP  ++ DG  +  ND    + NL +   +   IAT+ +  ++ E   W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKG + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAVF LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:   28 PGNTTVQLSASSVETPPPGYMSEDGDPMDHND----NMNLTRLTPSPGNIATEAAPVLYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVFQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPPLPCSSMS 281

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BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Match: A0A026WFV9 (Mothers against decapentaplegic homolog OS=Ooceraea biroi OX=2015173 GN=X777_04468 PE=3 SV=1)

HSP 1 Score: 259.996 bits (663), Expect = 4.643e-79
Identity = 132/282 (46.81%), Postives = 186/282 (65.96%), Query Frame = 2

Query:  503 ICINPRHYLISISAKSFSSPTNLSALLMEKNS------SVRPPTLTPD-GKRLNDLATVDCNLLKAIENASQIATDQS--IFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +C+NP HY      ++  +P ++ +L   + S      S+ PP  TP  G    D   +D N   ++   S    D    ++CE   W +++YYELN+RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E+TR+ IGKG + YYI GE+F ECLSD++IFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P   CSS S
Sbjct:  123 VCVNPYHYQ---RIQTPGTPASVGSLGSVQGSPHPAPGSMDPPADTPPPGYISEDGDNMDHNDNMSLSRLSPSPVDAQPVMYCEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNTVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 400

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BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Match: J9AUL3 (MH2 domain-containing protein OS=Wuchereria bancrofti OX=6293 GN=WUBG_10921 PE=4 SV=1)

HSP 1 Score: 254.218 bits (648), Expect = 4.953e-79
Identity = 118/221 (53.39%), Postives = 162/221 (73.30%), Query Frame = 2

Query:  653 TVDCNLLKAIENASQIATDQSIFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSS 1306
            T D ++ +   N + IA +   +CE   W +V+YYEL+ RVG+ F ++ P + +DGYT+PS  + RF LG L+NV+R+A++   RK IG+GA+FYYI  E+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN  +F  +L     +GFEAV+ALT +C+IR+SFVKGWGA Y RQTITATPCW+E +LN PL+ LD+ L+++ +P N+C+S
Sbjct:   16 TCDSSVTERANNLNLIAVE---YCEPPFWCSVSYYELSERVGETFHASQPSLIVDGYTAPS-DAERFCLGQLSNVNRTASVMEARKHIGRGARFYYIGSEVFCECLSDSAIFVQSPNCNQRHGWHPATVCKIPPNCNLKIFNNAEFAALLAASVPQGFEAVYALTRMCTIRVSFVKGWGAEYRRQTITATPCWIEAYLNGPLQWLDSVLKQMGSPPNRCTS 232

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Match: smad3b (mothers against decapentaplegic homolog 3 [Source:NCBI gene;Acc:103027004])

HSP 1 Score: 254.218 bits (648), Expect = 5.428e-80
Identity = 125/242 (51.65%), Postives = 170/242 (70.25%), Query Frame = 2

Query:  608 PPTLTPDG----KRLNDLATVDCNLLKAIENASQIATDQSIFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            P  L+ DG    +++N + T DC LL      S        +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS ++ RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  182 PGYLSEDGESSDQQMNHMDT-DCRLL------SHSHLQPVTYCESAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NAERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 415

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Match: smad3a (mothers against decapentaplegic homolog 3 [Source:NCBI gene;Acc:103027811])

HSP 1 Score: 252.292 bits (643), Expect = 4.399e-79
Identity = 139/329 (42.25%), Postives = 194/329 (58.97%), Query Frame = 2

Query:  395 VFHNKSNAESDALKHHHSASGSILNPVSAELSNENFICINPRHYLIS-----ISAKSFSSP--TNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSI-------------FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
             FH K +       H+      +L PV           + PRH  I      +   S S P  TN  A +  +++ +  P   P G    D  T D  +  +++  S   +   +             +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  111 AFHMKKDEVCVNPYHYQRVETPVLPPV-----------LVPRHTEIPSEFPPLDDYSHSIPENTNFPAGIEPQSNYI--PETPPPGYLSEDGETSDHQMNHSMDTGSPNLSPSPVSPANNNLDLQPVTYCEPAFWCSISYYELNQRVGEIFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Match: smad2 (SMAD family member 2 [Source:NCBI gene;Acc:103025750])

HSP 1 Score: 251.906 bits (642), Expect = 7.985e-79
Identity = 112/195 (57.44%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P+ +CSS S
Sbjct:  245 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPTVRCSSMS 438

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Match: smad3b (mothers against decapentaplegic homolog 3 [Source:NCBI gene;Acc:103027004])

HSP 1 Score: 251.136 bits (640), Expect = 1.007e-78
Identity = 114/201 (56.72%), Postives = 154/201 (76.62%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS ++ RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  225 YCESAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NAERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 424

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Match: smad2 (SMAD family member 2 [Source:NCBI gene;Acc:103025750])

HSP 1 Score: 251.521 bits (641), Expect = 2.066e-78
Identity = 112/195 (57.44%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +P+ +CSS S
Sbjct:  275 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPTVRCSSMS 468

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Match: SMAD3 (SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769])

HSP 1 Score: 248.825 bits (634), Expect = 1.339e-80
Identity = 113/202 (55.94%), Postives = 153/202 (75.74%), Query Frame = 2

Query:  716 IFCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            ++CE   W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+  +E TR+ IG+G + YYI GE+F ECLS++AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQTIT+TPCW+E+HLN PL+ LD  L ++ +P+ +CSS S
Sbjct:   63 MYCEPAFWCSIGYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNQVVEMTRRHIGRGVRLYYIGGEVFAECLSESAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVHQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTITSTPCWIELHLNGPLQWLDRVLTQMGSPTVRCSSIS 263

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Match: SMAD3 (SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769])

HSP 1 Score: 249.21 bits (635), Expect = 1.754e-78
Identity = 111/199 (55.78%), Postives = 152/199 (76.38%), Query Frame = 2

Query:  719 FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSS 1306
            +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+N++R+  +E TR+ IG+G + YYI GE+F ECLS++AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS
Sbjct:  235 YCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNINRNQTVEMTRRHIGRGVRLYYIGGEVFAECLSESAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSS 432

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Match: smad9 (SMAD family member 9 [Source:ZFIN;Acc:ZDB-GENE-031014-1])

HSP 1 Score: 216.853 bits (551), Expect = 8.847e-66
Identity = 107/242 (44.21%), Postives = 155/242 (64.05%), Query Frame = 2

Query:  608 PPTLTP-------DGKRLNDLATVDCNLLKAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            PP   P       DG +  + +T   + L    +   +  ++     W ++ YYEL +RVG+AF +++  V +DG+T PS + +RF LG L++V+R++ IE TR+ IGKG   YY+ GE+F ECLSD++IFVQS   N   G+HP TV KIP  C++K+FN ++F  +L +    GFEAV+ LT +C IR+SFVKGWGA Y RQ +T+TPCWVE+HL+ PL+ LD  L ++ +P    SS S
Sbjct:  224 PPAYVPPEDQNSQDGSQSMETSTTMVSTLPNTGDRQPVTYEEPK--HWCSIVYYELTNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSHVNRNSTIENTRRHIGKGVHLYYVGGEVFAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAGLLAESVNHGFEAVYELTKMCIIRMSFVKGWGAEYHRQDVTSTPCWVEIHLHGPLQWLDKVLTQMGSPHMPISSVS 463

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010406.1 (pep scaffold:Pmarinus_7.0:GL476769:63937:79511:-1 gene:ENSPMAG00000009414.1 transcript:ENSPMAT00000010406.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 129.798 bits (325), Expect = 4.970e-33
Identity = 78/222 (35.14%), Postives = 116/222 (52.25%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAF--ASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFY-YIKGELFLECLSDNAIFVQSPMSNITSGWHPATVI-KIPPKCNIKVFNEKDFKRILHQH-----------------ELRGFEAVFALTP-----------------LCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRL 1279
            W ++ Y+E++ +VG+ F   S+ PIVT+DGY  PS    RF LG L+NV R+   E+ R  IGKG +     +G++++ CLSD+A+FVQS   +  +G  P   + KI P   IKVF+ +   R + Q                   + G  +V  + P                 LC +R+SFVKGWG  Y R +I  TPCW+E+HL++ L+ LD  L  +
Sbjct:  338 WCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPS-GGDRFCLGQLSNVHRTDASEKARLHIGKGVQLECRGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRHSIKETPCWIEIHLHRALQLLDEVLHTM 558

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010514.1 (pep scaffold:Pmarinus_7.0:GL482855:12566:14836:-1 gene:ENSPMAG00000009525.1 transcript:ENSPMAT00000010514.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 83.5741 bits (205), Expect = 3.733e-19
Identity = 54/164 (32.93%), Postives = 80/164 (48.78%), Query Frame = 2

Query:  896 RKFIGKGAKFY-YIKGELFLECLSDNAIFVQSPMSNITSGWHPATVI-KIPPKCNIKVFNEKDFKRILHQH-----------------ELRGFEAVFALTP-----------------LCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRL 1279
            R  IGKG +     +G++++ CLSD+A+FVQS   +  +G  P   + KI P   IKVF+ +   R + Q                   + G  +V  + P                 LC +R+SFVKGWG  Y RQ+I  TPCW+E+HL++ L+ LD  L  +
Sbjct:    4 RLHIGKGVQLECRGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKQTPCWIEIHLHRALQLLDQVLHTM 167

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Match: EDO39594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L0])

HSP 1 Score: 249.98 bits (637), Expect = 1.101e-78
Identity = 112/195 (57.44%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W +++YYE+N+RVG+ F ++ P +T+DG+T PS  S RF LG L+N++R+  IE TRK IGKG + YYI GE+F ECLSD++IFVQSP  N    WHPATV KIPP CN+K+FN ++F ++L Q   +GFEAV+ALT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS  CSS S
Sbjct:  230 WCSISYYEMNTRVGETFHASQPSLTVDGFTDPS-SSDRFCLGLLSNINRNPPIEMTRKHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYNWHPATVCKIPPGCNLKIFNNQEFAQLLSQSVNQGFEAVYALTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSAPCSSVS 423

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Match: EDO47037 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNC1])

HSP 1 Score: 224.557 bits (571), Expect = 7.395e-69
Identity = 114/261 (43.68%), Postives = 166/261 (63.60%), Query Frame = 2

Query:  533 SISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSP-SPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            S  + SF    + +  + E   S RP     D   +N   ++     +A+ + + +   + +   W ++ YYELN+RVG+ F + +  + +DG+T P + +S RF LG L+NV+R++ IE TR+ IGKG   YY+ GE++ ECLSD+AIFVQS   N + G+HP TV KIP  C +K+FN ++F ++L Q    GFEAV+ LT +CSIRISFVKGWGA Y RQ +T+TPCW+EVHL+ PL+ LD  L ++ +P N  SS S
Sbjct:  178 SEQSPSFDMADSGAGYMSEDGGSPRPEPNAMDVDPVNSPPSIS-QSAEAMSHVTAVNYQEPL--SWCSIAYYELNNRVGELFHAKSTSLIVDGFTDPNTTNSERFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSAIFVQSRNCNHSHGFHPTTVCKIPSGCTLKIFNNQEFAQLLSQSVNYGFEAVYELTKMCSIRISFVKGWGAEYHRQDVTSTPCWIEVHLHGPLQWLDKVLSQMGSPRNPISSVS 435

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Match: EDO31382 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SY32])

HSP 1 Score: 136.732 bits (343), Expect = 4.852e-36
Identity = 77/185 (41.62%), Postives = 111/185 (60.00%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAF--ASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKF-YYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVI-KIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAAL 1270
            W ++ Y+EL+ +VG+ F   S  P VT+DGY  PS   +RF LG L+NV R+   ER R  IGKG +     +G++++ CLS++++FVQS   +  +G  P   + KI P   IKVF   D + +L Q        V  L  LC +R+SFVKGWG  Y R++I  TPCW+E+HL++ L+ LD  L
Sbjct:  209 WCSIAYFELDQQVGEIFKVTSNCPSVTVDGYVDPS-GGNRFCLGQLSNVHRTEASERARLHIGKGVQLDVRGEGDVWVRCLSEHSVFVQSYYLDREAGRCPGDAVHKIYPSAYIKVF---DLRALLPQMGQTSV-GVDDLRRLCILRLSFVKGWGPDYPRKSIKETPCWIEIHLHRALQLLDEIL 388

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Match: EDO39628 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9K9])

HSP 1 Score: 70.0922 bits (170), Expect = 2.724e-13
Identity = 70/259 (27.03%), Postives = 107/259 (41.31%), Query Frame = 2

Query:  503 ICINPRHYLISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLL--KAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLT-NVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSP----MSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHE---LRGFEAVFALTPLCSIRISFVKGWG----ASYSRQTITATPCWVEVHL 1237
            +CINP HY   I  +          LL   NS  +   L             DC  L  +  E+ S+  +       W  V Y+ELN  +G  +     ++ I   T P P    F L  L  N + S   +R R  +G G +    +  +++   S+ A+F        ++   S     TV K+PP  ++K+++        + H     R FE   +     S+RISF KGWG    ASY R  +T+ PCW+E+H 
Sbjct:   85 VCINPHHYSEIIQIR------KCKCLLKVNNSYNKFGCLYGHVLAHAKSYCSDCFFLPLELFESTSEWPS------AWCVVAYWELNECIGPFYHGHQDVINIYE-TLPKPKG--FCLAGLDRNQNVSDGTKRARNHVGFGLQLSREEDGIWIYNRSEYAVFANGTTFPYVTTTPSASQNITVTKVPPGFSLKIYD--------YNHSPATCRTFEGPQSWKVPESVRISFAKGWGNTSSASYRRPVVTSCPCWLEIHF 320

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Match: EDO25528 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DW81])

HSP 1 Score: 57.3806 bits (137), Expect = 6.173e-11
Identity = 29/63 (46.03%), Postives = 39/63 (61.90%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAF--ASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIG 910
            W ++ Y+EL+ +VG+ F   S  P VT+DGY  PS   +RF LG L+NV R+   ER R  IG
Sbjct:    5 WCSIAYFELDQQVGEIFKVTSNCPSVTVDGYVDPS-GGNRFCLGQLSNVHRTEASERARLHIG 66

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Match: ENSORLT00000014829.2 (SMAD family member 2 [Source:NCBI gene;Acc:101167556])

HSP 1 Score: 254.603 bits (649), Expect = 7.689e-80
Identity = 133/308 (43.18%), Postives = 182/308 (59.09%), Query Frame = 2

Query:  437 HHHSASGSILNPVSAELSNENFICINPRHYLISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCE----------------WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            H+      +L PV      E    + P    +     S    TN  A +   N+ +  P   P G    D  T D  + +++E+ S      S                    W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  143 HYQRVETPVLPPVLVPRHTEILTELPP----LDDFTNSIPENTNFPAGIEPPNNYI--PDTPPPGYMSEDGETSDQQMNQSMESGSPAEMSPSTLSPVTGMDLQPVTYSEPAFWCSIAYYELNQRVGENFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 443

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Match: ENSORLT00000002749.2 (mothers against decapentaplegic homolog 3 [Source:NCBI gene;Acc:101169523])

HSP 1 Score: 253.832 bits (647), Expect = 9.865e-80
Identity = 132/315 (41.90%), Postives = 189/315 (60.00%), Query Frame = 2

Query:  488 SNENFICINPRHYL------------------------ISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSI-------------FCE---WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            + ++ +C+NP HYL                        +   + S    TN  A +  +++ +  P   P G    D  T D  +  +++ +S   +   +             +CE   W +++YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS  CSS S
Sbjct:  114 TKKDEVCVNPYHYLRVETPVLPPVLVPRHTEIPSEFPPLDDYSHSIPENTNFPAGIEPQSNYI--PETPPPGYLSEDGETSDHQMTHSMDTSSPNLSPNPVSPTHSNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIHCSSVS 425

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Match: smad2 (mothers against decapentaplegic homolog 2 [Source:NCBI gene;Acc:101159109])

HSP 1 Score: 253.447 bits (646), Expect = 2.115e-79
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  244 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSARCSSMS 437

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Match: ENSORLT00000014832.2 (SMAD family member 2 [Source:NCBI gene;Acc:101167556])

HSP 1 Score: 253.832 bits (647), Expect = 3.778e-79
Identity = 133/308 (43.18%), Postives = 182/308 (59.09%), Query Frame = 2

Query:  437 HHHSASGSILNPVSAELSNENFICINPRHYLISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCE----------------WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            H+      +L PV      E    + P    +     S    TN  A +   N+ +  P   P G    D  T D  + +++E+ S      S                    W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  173 HYQRVETPVLPPVLVPRHTEILTELPP----LDDFTNSIPENTNFPAGIEPPNNYI--PDTPPPGYMSEDGETSDQQMNQSMESGSPAEMSPSTLSPVTGMDLQPVTYSEPAFWCSIAYYELNQRVGENFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 473

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BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Match: smad2 (mothers against decapentaplegic homolog 2 [Source:NCBI gene;Acc:101159109])

HSP 1 Score: 253.062 bits (645), Expect = 5.319e-79
Identity = 113/195 (57.95%), Postives = 150/195 (76.92%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYELN RVG+ F ++ P +T+DG+T PS +S RF LG L+NV+R+A +E TR+ IG+G + YYI GE+F ECLSD+AIFVQSP  N   GWHPATV KIPP CN+K+FN ++F  +L Q   +GFEAV+ LT +C+IR+SFVKGWGA Y RQT+T+TPCW+E+HLN PL+ LD  L ++ +PS +CSS S
Sbjct:  274 WCSIAYYELNQRVGETFHASQPSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSARCSSMS 467

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BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Match: SMESG000017169.1 (SMESG000017169.1)

HSP 1 Score: 229.565 bits (584), Expect = 9.456e-75
Identity = 107/107 (100.00%), Postives = 107/107 (100.00%), Query Frame = 2

Query:  992 MSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            MSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS
Sbjct:    1 MSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 107

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BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Match: SMESG000056334.1 (SMESG000056334.1)

HSP 1 Score: 233.802 bits (595), Expect = 2.787e-72
Identity = 125/297 (42.09%), Postives = 177/297 (59.60%), Query Frame = 2

Query:  488 SNENFICINPRHYLISISAKSFSSPTNLSALLMEKNSS-----------------VRPPTLT-PDGKRLNDLATVDCNLLKAIENASQIATDQSIFCE----WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            + E  ICINP HY      K   SP  L  +L+ ++S                  + P  +T P+G   +       +      +   ++  QS+  +    W TV YYELNSRVG+AF +  P + IDG+T PS ++ RF LG L+NV+R++ IE TR+ IGKG   YY+ GE+F ECLSD++IFVQS   N    +HP+TV KIPP C++K+F+ ++F   L +  + G+EA+F +T +C++R+SFVKGWGA Y RQ +T+TPCWVE+HLN PLK LD  L ++  P N  SS S
Sbjct:  121 AKEKEICINPYHY------KRIESPGILPPVLVPRHSEYPTFPSSINLLYPIPEPLMPFNVTYPNGFNSSKSTPNSLSDQSFSSSLDLLSGAQSVVYQEPRYWSTVVYYELNSRVGEAFHARLPSIIIDGFTDPSNNADRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVFAECLSDSSIFVQSRNCNYRHNFHPSTVCKIPPGCSLKIFSNREFAEQLSRTVVHGYEAIFEMTRMCTVRMSFVKGWGAEYHRQDVTSTPCWVEIHLNGPLKWLDRVLTKMGAPRNPISSVS 411

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BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Match: SMESG000056334.1 (SMESG000056334.1)

HSP 1 Score: 233.417 bits (594), Expect = 3.050e-72
Identity = 105/195 (53.85%), Postives = 142/195 (72.82%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W TV YYELNSRVG+AF +  P + IDG+T PS ++ RF LG L+NV+R++ IE TR+ IGKG   YY+ GE+F ECLSD++IFVQS   N    +HP+TV KIPP C++K+F+ ++F   L +  + G+EA+F +T +C++R+SFVKGWGA Y RQ +T+TPCWVE+HLN PLK LD  L ++  P N  SS S
Sbjct:  216 WSTVVYYELNSRVGEAFHARLPSIIIDGFTDPSNNADRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVFAECLSDSSIFVQSRNCNYRHNFHPSTVCKIPPGCSLKIFSNREFAEQLSRTVVHGYEAIFEMTRMCTVRMSFVKGWGAEYHRQDVTSTPCWVEIHLNGPLKWLDRVLTKMGAPRNPISSVS 410

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Match: SMESG000031386.1 (SMESG000031386.1)

HSP 1 Score: 234.572 bits (597), Expect = 1.852e-71
Identity = 104/195 (53.33%), Postives = 142/195 (72.82%), Query Frame = 2

Query:  728 WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            W ++ YYEL+   G+ F  +T  +T+DG+T P+  S RF LG ++NV+R+   E  R+ IGKG + YYI GE+F ECLS++AIFVQSP  N  +GWHPATV KIPP+CN+K+F+ + F ++L     +GFEAVF LT +CSIR+SFVKGWG+ Y RQT+T TPCW+E+HLN PL+ LD  L+ +E+P   C+S S
Sbjct:  315 WCSIRYYELSVAFGETFHCSTSCLTVDGFTDPA-QSDRFCLGLVSNVNRNPQTELARRHIGKGLRLYYIGGEVFAECLSESAIFVQSPNCNYLNGWHPATVCKIPPRCNLKIFDNQVFAQLLADSVSKGFEAVFTLTHMCSIRLSFVKGWGSDYRRQTVTNTPCWIEIHLNGPLQWLDRVLKEMESPLMPCNSVS 508

[Close]

BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Match: SMESG000011457.1 (SMESG000011457.1)

HSP 1 Score: 224.557 bits (571), Expect = 2.695e-68
Identity = 107/238 (44.96%), Postives = 159/238 (66.81%), Query Frame = 2

Query:  611 PTLTPDGKRLNDLATVDCNLLKAIENASQIATDQSIFCE----WGTVTYYELNSRVGDAFASATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYYIKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDFKRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEVHLNQPLKCLDAALQRLETPSNQCSSRS 1312
            P++  +G   +D    + +  + ++ +S     QS+  +    W ++ YYELN+RVG+AF ++   + +DG+T PS +S RF LG L+NV+R++ IE TR+ IGKG   YY+ G+++ ECLSD++IFVQS   N    +HP TV KIPP C++K+F+ ++F  +L +    GFEAV+ LT +C+IR+SFVKGWGA Y RQ +T+TPCW+E+HLN PL  LD  L ++ TP N  SS S
Sbjct:  218 PSINGNGNTSSDTPITNISQPQPMDVSSVPKNMQSVTYQEPKNWCSIVYYELNNRVGEAFFASKLSIIVDGFTDPSNNSDRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGDVYAECLSDSSIFVQSRNCNYHHNFHPTTVCKIPPGCSLKIFSNQEFAFLLSRTVHHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLNGPLHWLDKVLSQMGTPRNPISSVS 455

The following BLAST results are available for this feature:

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Zebrafish
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Yeast
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SMAD3	8.606e-82	57.21	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:...	[more]
SMAD3	1.788e-80	57.21	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:...	[more]
SMAD3	4.048e-79	57.21	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:...	[more]
SMAD2	6.121e-79	57.95	SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:...	[more]
SMAD2	6.121e-79	57.95	SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sma-2	2.913e-58	48.92	Dwarfin sma-2 [Source:UniProtKB/Swiss-Prot;Acc:Q0...	[more]
sma-2	2.913e-58	48.92	Dwarfin sma-2 [Source:UniProtKB/Swiss-Prot;Acc:Q0...	[more]
sma-3	3.469e-40	33.83	Dwarfin sma-3 [Source:UniProtKB/Swiss-Prot;Acc:P4...	[more]
daf-8	1.875e-38	36.36	Dwarfin sma [Source:UniProtKB/TrEMBL;Acc:Q21733]	[more]
daf-14	1.963e-25	33.97	Smad protein [Source:UniProtKB/TrEMBL;Acc:G5EEP2]	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Smox	2.184e-79	49.38	gene:FBgn0025800 transcript:FBtr0340159	[more]
Smox	2.184e-79	49.38	gene:FBgn0025800 transcript:FBtr0071192	[more]
Mad	2.357e-71	41.61	gene:FBgn0011648 transcript:FBtr0077616	[more]
Mad	1.062e-70	41.61	gene:FBgn0011648 transcript:FBtr0332372	[more]
Med	8.949e-35	38.07	gene:FBgn0011655 transcript:FBtr0085816	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
smad3a	4.765e-79	42.68	SMAD family member 3a [Source:ZFIN;Acc:ZDB-GENE-00...	[more]
smad3a	4.765e-79	42.68	SMAD family member 3a [Source:ZFIN;Acc:ZDB-GENE-00...	[more]
smad2	1.038e-78	57.95	SMAD family member 2 [Source:NCBI gene;Acc:30639]	[more]
smad2	1.038e-78	57.95	SMAD family member 2 [Source:NCBI gene;Acc:30639]	[more]
smad2	1.038e-78	57.95	SMAD family member 2 [Source:NCBI gene;Acc:30639]	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rgs19	1.651e-80	57.71	regulator of G-protein signaling 19 [Source:Xenbas...	[more]
rgs19	5.192e-80	57.71	regulator of G-protein signaling 19 [Source:Xenbas...	[more]
rgs19	5.331e-80	57.71	regulator of G-protein signaling 19 [Source:Xenbas...	[more]
rgs19	6.440e-80	57.71	regulator of G-protein signaling 19 [Source:Xenbas...	[more]
eif3m	9.542e-80	57.95	eukaryotic translation initiation factor 3 subunit...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Smad2	4.202e-79	57.95	SMAD family member 2 [Source:MGI Symbol;Acc:MGI:10...	[more]
Smad3	4.620e-79	57.21	SMAD family member 3 [Source:MGI Symbol;Acc:MGI:12...	[more]
Smad2	7.915e-79	57.95	SMAD family member 2 [Source:MGI Symbol;Acc:MGI:10...	[more]
Smad2	7.915e-79	57.95	SMAD family member 2 [Source:MGI Symbol;Acc:MGI:10...	[more]
Smad5	2.741e-69	52.82	SMAD family member 5 [Source:MGI Symbol;Acc:MGI:13...	[more]

BLAST of Mothers against decapentaplegic homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P84025\|SMAD3_RAT	3.231e-78	57.21	Mothers against decapentaplegic homolog 3 OS=Rattu...	[more]
sp\|P84024\|SMAD3_PIG	3.231e-78	57.21	Mothers against decapentaplegic homolog 3 OS=Sus s...	[more]
sp\|Q8BUN5\|SMAD3_MOUSE	3.231e-78	57.21	Mothers against decapentaplegic homolog 3 OS=Mus m...	[more]
sp\|P84022\|SMAD3_HUMAN	3.231e-78	57.21	Mothers against decapentaplegic homolog 3 OS=Homo ...	[more]
sp\|P84023\|SMAD3_CHICK	3.432e-78	57.21	Mothers against decapentaplegic homolog 3 OS=Gallu...	[more]

BLAST of Mothers against decapentaplegic homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
V9ILI5	2.956e-79	56.44	Mothers against decapentaplegic 3 OS=Apis cerana O...	[more]
E9G7J0	3.257e-79	46.34	Mothers against decapentaplegic homolog OS=Daphnia...	[more]
S4NSR1	3.467e-79	49.42	Smad on X OS=Pararge aegeria OX=116150 PE=4 SV=1	[more]
A0A026WFV9	4.643e-79	46.81	Mothers against decapentaplegic homolog OS=Oocerae...	[more]
J9AUL3	4.953e-79	53.39	MH2 domain-containing protein OS=Wuchereria bancro...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
smad3b	5.428e-80	51.65	mothers against decapentaplegic homolog 3 [Source:...	[more]
smad3a	4.399e-79	42.25	mothers against decapentaplegic homolog 3 [Source:...	[more]
smad2	7.985e-79	57.44	SMAD family member 2 [Source:NCBI gene;Acc:1030257...	[more]
smad3b	1.007e-78	56.72	mothers against decapentaplegic homolog 3 [Source:...	[more]
smad2	2.066e-78	57.44	SMAD family member 2 [Source:NCBI gene;Acc:1030257...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SMAD3	1.339e-80	55.94	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:...	[more]
SMAD3	1.754e-78	55.78	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:...	[more]
smad9	8.847e-66	44.21	SMAD family member 9 [Source:ZFIN;Acc:ZDB-GENE-031...	[more]
ENSPMAT00000010406.1	4.970e-33	35.14	pep scaffold:Pmarinus_7.0:GL476769:63937:79511:-1 ...	[more]
ENSPMAT00000010514.1	3.733e-19	32.93	pep scaffold:Pmarinus_7.0:GL482855:12566:14836:-1 ...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO39594	1.101e-78	57.44	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47037	7.395e-69	43.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31382	4.852e-36	41.62	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39628	2.724e-13	27.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO25528	6.173e-11	46.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000014829.2	7.689e-80	43.18	SMAD family member 2 [Source:NCBI gene;Acc:1011675...	[more]
ENSORLT00000002749.2	9.865e-80	41.90	mothers against decapentaplegic homolog 3 [Source:...	[more]
smad2	2.115e-79	57.95	mothers against decapentaplegic homolog 2 [Source:...	[more]
ENSORLT00000014832.2	3.778e-79	43.18	SMAD family member 2 [Source:NCBI gene;Acc:1011675...	[more]
smad2	5.319e-79	57.95	mothers against decapentaplegic homolog 2 [Source:...	[more]

BLAST of Mothers against decapentaplegic homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000017169.1	9.456e-75	100.00	SMESG000017169.1	[more]
SMESG000056334.1	2.787e-72	42.09	SMESG000056334.1	[more]
SMESG000056334.1	3.050e-72	53.85	SMESG000056334.1	[more]
SMESG000031386.1	1.852e-71	53.33	SMESG000031386.1	[more]
SMESG000011457.1	2.695e-68	44.96	SMESG000011457.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30004641 ID=SMED30004641|Name=Mothers against decapentaplegic homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1324bp
CTATATAAATCTTATATGATGATAAAATTATATGGTTGTTAAAATGGATG
TTAAAAGAAAGCTTTCTGTAAATAATGAAGAAAATCATGTAAGCGGGGAT
AGTTTTATAAATCGGGAATGCCAAAAAAAGATTTTTGAAGCTTATTTTTT
TATATTATTAGAATATTTAAATAATAAGAAAAAATTTGAAATCAAAGCAA
ATGATTTGATTTATTCAGATAGCTGTATATTAATTTCTCGATCGATTCAG
CCATATTTGATGAAACGTTTCCATAGCTATTGTAGGAAATTAAACATCGA
CTATAAATCTATGAATCATATCATTCCGGTGGATAACTCGTATTCCATCG
CATCGATTATTAGCGTTGTCAATAATTATCGCAACCCTGGTAAAGTGTTC
CACAATAAATCCAATGCTGAATCCGATGCATTGAAACATCACCACTCAGC
GTCCGGATCGATACTTAATCCCGTTTCCGCAGAATTATCAAATGAGAACT
TTATCTGTATTAATCCGCGCCATTATTTAATTTCAATCTCAGCAAAATCT
TTCTCGTCTCCCACAAACTTGTCTGCATTGCTGATGGAAAAGAACTCATC
CGTCCGGCCTCCAACGCTTACACCGGACGGGAAACGGCTGAATGACCTCG
CCACTGTCGACTGTAACCTGTTGAAAGCCATAGAAAACGCCAGCCAAATA
GCAACTGACCAATCGATATTCTGTGAATGGGGCACCGTGACGTACTACGA
GCTGAACTCGCGAGTCGGTGACGCGTTCGCGTCCGCAACTCCCATTGTCA
CCATTGACGGTTACACCTCACCGTCGCCTCACAGCAGCAGGTTCAGTCTC
GGCCATTTGACCAATGTTTCCAGGAGCGCCAATATCGAGAGGACCAGAAA
ATTTATCGGCAAAGGCGCTAAATTTTACTACATAAAAGGAGAATTGTTCC
TCGAATGTTTGAGTGACAATGCAATATTTGTCCAATCTCCCATGTCAAAT
ATCACATCTGGCTGGCATCCTGCTACGGTCATAAAAATACCTCCGAAATG
CAACATCAAGGTGTTTAATGAAAAAGATTTCAAGAGAATTTTGCATCAGC
ATGAATTACGCGGATTCGAAGCAGTTTTTGCTTTGACTCCTCTATGTTCT
ATCAGAATCAGCTTTGTCAAAGGTTGGGGTGCATCATACAGCCGTCAAAC
CATTACTGCAACACCATGTTGGGTAGAAGTGCATTTAAATCAACCATTAA
AGTGCCTAGATGCAGCTTTACAGCGGCTGGAAACTCCATCAAATCAGTGT
TCTTCAAGAAGTTGAAATTTTAAA

protein sequence of SMED30004641-orf-1

>SMED30004641-orf-1 ID=SMED30004641-orf-1|Name=SMED30004641-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=428bp
MVVKMDVKRKLSVNNEENHVSGDSFINRECQKKIFEAYFFILLEYLNNKK
KFEIKANDLIYSDSCILISRSIQPYLMKRFHSYCRKLNIDYKSMNHIIPV
DNSYSIASIISVVNNYRNPGKVFHNKSNAESDALKHHHSASGSILNPVSA
ELSNENFICINPRHYLISISAKSFSSPTNLSALLMEKNSSVRPPTLTPDG
KRLNDLATVDCNLLKAIENASQIATDQSIFCEWGTVTYYELNSRVGDAFA
SATPIVTIDGYTSPSPHSSRFSLGHLTNVSRSANIERTRKFIGKGAKFYY
IKGELFLECLSDNAIFVQSPMSNITSGWHPATVIKIPPKCNIKVFNEKDF
KRILHQHELRGFEAVFALTPLCSIRISFVKGWGASYSRQTITATPCWVEV
HLNQPLKCLDAALQRLETPSNQCSSRS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR013790	Dwarfin
IPR001132	SMAD_dom_Dwarfin-type
IPR017855	SMAD-like_dom_sf
IPR008984	SMAD_FHA_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007183	SMAD protein complex assembly
GO:0007352	zygotic specification of dorsal/ventral axis
GO:0007369	gastrulation
GO:0007389	pattern specification process
GO:0007492	endoderm development
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009749	response to glucose
GO:0009791	post-embryonic development
GO:0009880	embryonic pattern specification
GO:0009952	anterior/posterior pattern specification
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030073	insulin secretion
GO:0030324	lung development
GO:0030513	positive regulation of BMP signaling pathway
GO:0031016	pancreas development
GO:0032924	activin receptor signaling pathway
GO:0035265	organ growth
GO:0035556	intracellular signal transduction
GO:0038092	nodal signaling pathway
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048340	paraxial mesoderm morphogenesis
GO:0048589	developmental growth
GO:0048617	embryonic foregut morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0051098	regulation of binding
GO:0060021	palate development
GO:0060039	pericardium development
GO:0060395	SMAD protein signal transduction
GO:0070723	response to cholesterol
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0000790	nuclear chromatin
GO:0043234	protein complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0032444	activin responsive factor complex
GO:0071141	SMAD protein complex
GO:0071144	SMAD2-SMAD3 protein complex

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0042803	protein homodimerization activity
GO:0003690	double-stranded DNA binding
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0005160	transforming growth factor beta receptor binding
GO:0008134	transcription factor binding
GO:0019902	phosphatase binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0033613	activating transcription factor binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001132	SMAD domain, Dwarfin-type	SMART	SM00524	dwBultra2	coord: 231..403 e-value: 9.6E-79 score: 277.6
IPR001132	SMAD domain, Dwarfin-type	PFAM	PF03166	MH2	coord: 232..403 e-value: 1.6E-61 score: 207.8
IPR001132	SMAD domain, Dwarfin-type	PROSITE	PS51076	MH2	coord: 233..427 score: 59.892
IPR017855	SMAD-like domain superfamily	GENE3D	G3DSA:2.60.200.10		coord: 228..427 e-value: 3.1E-75 score: 254.1
IPR013790	Dwarfin	PANTHER	PTHR13703	SMAD	coord: 231..427
None	No IPR available	PANTHER	PTHR13703:SF42	MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2	coord: 231..427
IPR008984	SMAD/FHA domain superfamily	SUPERFAMILY	SSF49879	SMAD/FHA domain	coord: 228..415

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Mothers against decapentaplegic homolog

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

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