Mitogen-activated protein kinase kinase 6

Overview
NameMitogen-activated protein kinase kinase 6
Smed IDSMED30004633
Length (bp)1363
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitogen-activated protein kinase kinase 6 (SMED30004633) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase 6 (SMED30004633) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase 6 (SMED30004633) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase 6 (SMED30004633) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30004633

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30004633h1SMcG0011360 Contig5250GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30004633h1SMcG0010047 Contig5250GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Smed sexual biotypeSMED30004633h1SMcG0011360 Contig5250GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30004633h1SMcG0010047 Contig5250GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
parenchymal cellSMED30004633h1SMcG0011360 dd_Smed_v4_1286_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30004633h1SMcG0011360 dd_Smed_v4_1286_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
gutSMED30004633h1SMcG0011360 SMED30004633smed_20140614PMID:27441386
Arnold et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
anterior region of the whole animalSMED30004633h1SMcG0011360 SMED30004633smed_20140614PMID:27441386
Arnold et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30004633h1SMcG0011360 SMED30004633smed_20140614PMID:27441386
Arnold et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K6 (mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846])

HSP 1 Score: 312.768 bits (800), Expect = 1.957e-103
Identity = 164/330 (49.70%), Postives = 214/330 (64.85%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVLLG 1136
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K   +R +Y  L++H   T       L ESK         ++LG
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT-------LHESKGTDVASFVKLILG 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K3 (mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843])

HSP 1 Score: 302.368 bits (773), Expect = 1.424e-99
Identity = 154/311 (49.52%), Postives = 209/311 (67.20%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ DK+    IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV  +  P LP D  +S     F +QCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   14 NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKN--MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV-EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 314
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K3 (mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843])

HSP 1 Score: 302.368 bits (773), Expect = 1.424e-99
Identity = 154/311 (49.52%), Postives = 209/311 (67.20%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ DK+    IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV  +  P LP D  +S     F +QCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   14 NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKN--MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV-EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 314
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K3 (mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843])

HSP 1 Score: 302.368 bits (773), Expect = 1.424e-99
Identity = 154/311 (49.52%), Postives = 209/311 (67.20%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ DK+    IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV  +  P LP D  +S     F +QCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   14 NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKN--MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV-EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 314
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K3 (mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843])

HSP 1 Score: 302.753 bits (774), Expect = 2.585e-99
Identity = 154/311 (49.52%), Postives = 209/311 (67.20%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ DK+    IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV  +  P LP D  +S     F +QCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   43 NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKN--MTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV-EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 343
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-1 (Dual specificity mitogen-activated protein kinase kinase sek-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDF7])

HSP 1 Score: 269.24 bits (687), Expect = 7.005e-87
Identity = 139/332 (41.87%), Postives = 214/332 (64.46%), Query Frame = 3 
Query:  141 PTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFY-HKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            PT  +T ++    L  + +  L++ +E      +I +A  D+  + +LG+G YG+VEKM+H+ S +I AVK+I+ S+ND+ Q+++LN+L+   RS  CP +V  YGAMF+ GDVWICME++D+SLDKFY H  K       IPE  +  +   ++  L ++  +L++IHRDVKPSN L+++ G+VK+CDFGISG L NSMAKT   G +PY+ PERI+ + + S Y +R+DVWSLG++++E+A+   PY+ W + F+QLK VV  + PP LP +S +S   ++F+ +CL K  ++R  Y  L+    +   +NEK  Q S  RF     D +
Sbjct:   18 PTPVETPTMN---LEDRCLIKLTNESE------EIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKI---GKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGE-TKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVV-KEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEK--QFSMARFINEILDTV 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-1 (Dual specificity mitogen-activated protein kinase kinase sek-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDF7])

HSP 1 Score: 269.24 bits (687), Expect = 7.005e-87
Identity = 139/332 (41.87%), Postives = 214/332 (64.46%), Query Frame = 3 
Query:  141 PTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFY-HKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            PT  +T ++    L  + +  L++ +E      +I +A  D+  + +LG+G YG+VEKM+H+ S +I AVK+I+ S+ND+ Q+++LN+L+   RS  CP +V  YGAMF+ GDVWICME++D+SLDKFY H  K       IPE  +  +   ++  L ++  +L++IHRDVKPSN L+++ G+VK+CDFGISG L NSMAKT   G +PY+ PERI+ + + S Y +R+DVWSLG++++E+A+   PY+ W + F+QLK VV  + PP LP +S +S   ++F+ +CL K  ++R  Y  L+    +   +NEK  Q S  RF     D +
Sbjct:   18 PTPVETPTMN---LEDRCLIKLTNESE------EIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKI---GKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGE-TKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVV-KEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEK--QFSMARFINEILDTV 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: mkk-4 (MAP kinase kinase mkk-4 [Source:UniProtKB/Swiss-Prot;Acc:Q20347])

HSP 1 Score: 241.891 bits (616), Expect = 6.826e-76
Identity = 127/269 (47.21%), Postives = 171/269 (63.57%), Query Frame = 3 
Query:  246 TVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCS-MNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALP--NDSTYSNTVRHFISQCLIKKDSDRASYDVL 1040
            T +  +++ +  +G G +G V KMRHK +  + AVK+IRC+ +  +EQ RLL + +  ++S K P +V  YGA+F  GD WICMEL+D S+D  Y ++      + + E ++ +IT C V AL+YL +EL +IHRDVKPSN L+D  G VK+CDFGI G L  S AKT + G QPYLAPERI    S   Y +RSDVWSLG+++ E+A  KFPY  WNSLFDQ+  VV+ D P   P  +D  YS  +  FI+ CL K    R  YD L
Sbjct:   60 TFSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVY-MVKNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERIT---SSDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTL 324
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-6 (SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:O01706])

HSP 1 Score: 208.379 bits (529), Expect = 4.697e-63
Identity = 114/260 (43.85%), Postives = 161/260 (61.92%), Query Frame = 3 
Query:  261 DMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASY 1031
            ++  + ++G G YG V KM+H  S  + AVKKIR + N  +Q RLL + +  M+S   P +V  +GA F  GD WICMEL+D S+D  Y ++     K+ + E ++ +IT C+V AL+YL R+L+ IHRDVKPSN LI+  G VK+CDFGI GDL+ S A T   G   YLAPERI    +   Y IRSDVWSLG+++ E+A   +PY  W++  + ++ VV  D+P  L N  +  Y++ +  FI+ CL K   DR  Y
Sbjct:   63 NLRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN-NICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSV-KKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIE---NMDKYDIRSDVWSLGITLYEIATGVYPYRGWSNQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKY 317
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-3 (SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:Q8MPS3])

HSP 1 Score: 207.223 bits (526), Expect = 1.802e-62
Identity = 113/282 (40.07%), Postives = 174/282 (61.70%), Query Frame = 3 
Query:  264 MESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMN------DKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNS--LFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKY 1082
            ++ +  LG G +GVV KM H+PS++  AVK+I    N      +K  +R   ++  +  ++ C  +V  YG  F  G  W+CMEL+D SLDK Y    D   K  IPE++L  +    + ALE+L    H+IHRD+KPSN L+D+ G VK+CDFGI G L NS+A++ ++G +PY+APER+ P+  G GY I+S+VWSLG++++E+A  K+PY  +    + DQ++ VV  D PP L +D   S +++ FI+ C IK  + RAS+D L +  +   +  E++
Sbjct:   71 LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDIQ-KVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPN--GDGYDIKSEVWSLGITMVEVANGKYPYDGFMDAPILDQVRMVVYGD-PPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIYRDYIQEEH 348
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: lic (gene:FBgn0261524 transcript:FBtr0073720)

HSP 1 Score: 281.567 bits (719), Expect = 1.589e-91
Identity = 142/311 (45.66%), Postives = 208/311 (66.88%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +L     +Q+      +    +E I  LG G YG+V+KMRHK +  + AVK+I  ++N +EQ RL+ DL+ISMRS+ CPY V  YGAM++ GDVWICME++ +SLDKFY K+   D +  + E +L  I   +V+AL YLH +L VIHRDVKPSN LI++ G+VK+CDFGISG L++S+AKT + G +PY+APERI+P  + + Y IRSDVWSLG+ ++E+A  ++PY  W + F+QL+ VV  D+PP LP + T+S     FI+ CL K+   R +Y+ L++H  +      ++LQ + T  +E+   +L
Sbjct:   25 NLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLR--MEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVV-EDSPPRLP-EGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIV-----EHLQRN-TDISEFVARIL 325
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0334320)

HSP 1 Score: 277.33 bits (708), Expect = 8.272e-89
Identity = 143/303 (47.19%), Postives = 197/303 (65.02%), Query Frame = 3 
Query:  231 NGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALP--NDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
              N  T    D+E   ++G G +G V KM  K    + AVK+IR ++++KEQ++LL DL + M+S +C Y+V  YGA+F+ GD WICMEL+D+SLDKFY  I +K  +  IPE +LA IT   V AL YL  EL +IHRDVKPSN L+ +RG +K+CDFGISG L++S+AKT + G +PY+APERI+P+    GY +RSDVWSLG++++E+A   FPY +W+S+F+QL  VV  + P  L   N   +S     F++ CLIKK+SDR  Y  L+E     PF      + S T  A Y  D+L
Sbjct:  111 GANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQR-HIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE----MPFIRRG--ETSHTDVAVYVADIL 405
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0081892)

HSP 1 Score: 277.33 bits (708), Expect = 8.272e-89
Identity = 143/303 (47.19%), Postives = 197/303 (65.02%), Query Frame = 3 
Query:  231 NGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALP--NDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
              N  T    D+E   ++G G +G V KM  K    + AVK+IR ++++KEQ++LL DL + M+S +C Y+V  YGA+F+ GD WICMEL+D+SLDKFY  I +K  +  IPE +LA IT   V AL YL  EL +IHRDVKPSN L+ +RG +K+CDFGISG L++S+AKT + G +PY+APERI+P+    GY +RSDVWSLG++++E+A   FPY +W+S+F+QL  VV  + P  L   N   +S     F++ CLIKK+SDR  Y  L+E     PF      + S T  A Y  D+L
Sbjct:  111 GANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQR-HIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE----MPFIRRG--ETSHTDVAVYVADIL 405
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0300443)

HSP 1 Score: 277.33 bits (708), Expect = 8.272e-89
Identity = 143/303 (47.19%), Postives = 197/303 (65.02%), Query Frame = 3 
Query:  231 NGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALP--NDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
              N  T    D+E   ++G G +G V KM  K    + AVK+IR ++++KEQ++LL DL + M+S +C Y+V  YGA+F+ GD WICMEL+D+SLDKFY  I +K  +  IPE +LA IT   V AL YL  EL +IHRDVKPSN L+ +RG +K+CDFGISG L++S+AKT + G +PY+APERI+P+    GY +RSDVWSLG++++E+A   FPY +W+S+F+QL  VV  + P  L   N   +S     F++ CLIKK+SDR  Y  L+E     PF      + S T  A Y  D+L
Sbjct:  111 GANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQR-HIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLE----MPFIRRG--ETSHTDVAVYVADIL 405
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: hep (gene:FBgn0010303 transcript:FBtr0330397)

HSP 1 Score: 220.32 bits (560), Expect = 5.691e-66
Identity = 121/290 (41.72%), Postives = 171/290 (58.97%), Query Frame = 3 
Query:  219 EVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTY--SNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEK 1079
            ++ +NG +    I D++ +  LG G  G V KM H  S+ I AVK++R + N +E +R+L DL++ ++S  C Y+V   G   +  DVWICMEL+    DK       K  K  +PE++L  +T   V AL YL  +  VIHRDVKPSN LID+RG +K+CDFGISG L++S A T + G   Y+APERI  DP    Y IR+DVWSLG++++ELA  + PY   N+ F+ L  V+ S+ PP LP    Y  S   R F+ +CL K   DR  Y  L+    +  +++ K
Sbjct:  182 KLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLL-----KLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERI--DPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSE-PPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAK 463
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239])

HSP 1 Score: 303.908 bits (777), Expect = 7.743e-100
Identity = 149/287 (51.92%), Postives = 200/287 (69.69%), Query Frame = 3 
Query:  204 LSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            L     V +      V   D+E I +LG G YGVV+KMRH PS +I AVK+IR ++N +EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY ++ +K     IPE +L  IT  +V ALE+LH  L VIHRDVKPSN LI+ +G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K  ++R +Y  L++H   T
Sbjct:   62 LDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADR-FSADFVDFTSQCLRKNSTERPTYTELMQHPFFT 344
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239])

HSP 1 Score: 303.908 bits (777), Expect = 8.272e-100
Identity = 149/287 (51.92%), Postives = 200/287 (69.69%), Query Frame = 3 
Query:  204 LSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            L     V +      V   D+E I +LG G YGVV+KMRH PS +I AVK+IR ++N +EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY ++ +K     IPE +L  IT  +V ALE+LH  L VIHRDVKPSN LI+ +G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K  ++R +Y  L++H   T
Sbjct:   60 LDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADR-FSADFVDFTSQCLRKNSTERPTYTELMQHPFFT 342
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4a (mitogen-activated protein kinase kinase 4a [Source:ZFIN;Acc:ZDB-GENE-060512-98])

HSP 1 Score: 281.182 bits (718), Expect = 2.279e-90
Identity = 132/274 (48.18%), Postives = 191/274 (69.71%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            +D++ + ++G G YG V KM HKPS  I AVK+IR +++++EQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY  +     +  IPE +L  IT   V AL +L   L +IHRD+KPSN L+D++G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L +  +  +S    +F++ CL K +S R  Y  L++H  +  ++
Sbjct:  105 EDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSSLDEV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMYE 376
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4a (mitogen-activated protein kinase kinase 4a [Source:ZFIN;Acc:ZDB-GENE-060512-98])

HSP 1 Score: 280.026 bits (715), Expect = 2.822e-90
Identity = 136/294 (46.26%), Postives = 196/294 (66.67%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +D++ + ++G G YG V KM HKPS  I AVK+IR +++++EQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY  +     +  IPE +L  IT   V AL +L   L +IHRD+KPSN L+D++G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L +  +  +S    +F++ CL K +S R  Y  L++H  +  +      +E     A Y   +L
Sbjct:   79 EDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSSLDEV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMY------EERSVDVATYVCRIL 364
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4b (mitogen-activated protein kinase kinase 4b [Source:ZFIN;Acc:ZDB-GENE-080721-13])

HSP 1 Score: 279.256 bits (713), Expect = 2.138e-89
Identity = 141/322 (43.79%), Postives = 203/322 (63.04%), Query Frame = 3 
Query:  105 FRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNK-ITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPAL--PNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            F N   +P    P T    + Q   +      S+    +++++  +      +D++ + ++G G YG V  M HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +SLDKFY  +        IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY RWNS+FDQL  VV  + PP L    D  +S+    F++ CL K +S R  Y  L++H  +
Sbjct:   66 FANPPVKPAARLPITSTAPAFQNPHIERLRTHSIESSGKLKISPEQHCDFTAEDLKDLGEIGRGAYGSVNNMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKYVYCASDDV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPRWNSVFDQLTQVVKGE-PPQLCSSEDRQFSHKFIQFVNLCLTKDESKRPKYRELLKHPFI 385
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132])

HSP 1 Score: 301.982 bits (772), Expect = 2.884e-99
Identity = 161/343 (46.94%), Postives = 214/343 (62.39%), Query Frame = 3 
Query:  108 RNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            +    +P   SPT P+    +   L G+                   V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  C + V  YGA+F+ GDVWICMEL+D+SLDKFY  + DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F S+CL K   +R +Y  L++H           L ESK T  A +   +L
Sbjct:   16 KEAFDQPQVSSPTPPRDLDSKACILIGE---------------KNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKG--LTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSAEFVDFTSKCLKKNSKERPTYPELMQHHFFV-------LHESKNTDVASFVKRIL 332
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132])

HSP 1 Score: 301.597 bits (771), Expect = 4.078e-99
Identity = 161/343 (46.94%), Postives = 214/343 (62.39%), Query Frame = 3 
Query:  108 RNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            +    +P   SPT P+    +   L G+                   V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  C + V  YGA+F+ GDVWICMEL+D+SLDKFY  + DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F S+CL K   +R +Y  L++H           L ESK T  A +   +L
Sbjct:   17 KEAFDQPQVSSPTPPRDLDSKACILIGE---------------KNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKG--LTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSAEFVDFTSKCLKKNSKERPTYPELMQHHFFV-------LHESKNTDVASFVKRIL 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132])

HSP 1 Score: 300.056 bits (767), Expect = 5.457e-99
Identity = 154/296 (52.03%), Postives = 202/296 (68.24%), Query Frame = 3 
Query:  249 VAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  C + V  YGA+F+ GDVWICMEL+D+SLDKFY  + DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV  +  P LP D  +S     F S+CL K   +R +Y  L++H           L ESK T  A +   +L
Sbjct:   11 VKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKG--LTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVV-EEPSPQLPADK-FSAEFVDFTSKCLKKNSKERPTYPELMQHHFFV-------LHESKNTDVASFVKRIL 295
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132])

HSP 1 Score: 301.212 bits (770), Expect = 9.336e-99
Identity = 161/343 (46.94%), Postives = 214/343 (62.39%), Query Frame = 3 
Query:  108 RNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            +    +P   SPT P+    +   L G+                   V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  C + V  YGA+F+ GDVWICMEL+D+SLDKFY  + DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV  +  P LP D  +S     F S+CL K   +R +Y  L++H           L ESK T  A +   +L
Sbjct:   37 KEAFDQPQVSSPTPPRDLDSKACILIGE---------------KNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKG--LTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVV-EEPSPQLPADK-FSAEFVDFTSKCLKKNSKERPTYPELMQHHFFV-------LHESKNTDVASFVKRIL 353
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132])

HSP 1 Score: 299.286 bits (765), Expect = 9.799e-99
Identity = 154/296 (52.03%), Postives = 202/296 (68.24%), Query Frame = 3 
Query:  249 VAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  C + V  YGA+F+ GDVWICMEL+D+SLDKFY  + DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV  +  P LP D  +S     F S+CL K   +R +Y  L++H           L ESK T  A +   +L
Sbjct:   11 VKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKG--LTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVV-EEPSPQLPADK-FSAEFVDFTSKCLKKNSKERPTYPELMQHHFFV-------LHESKNTDVASFVKRIL 295
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k6 (mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870])

HSP 1 Score: 310.457 bits (794), Expect = 1.137e-102
Identity = 157/305 (51.48%), Postives = 206/305 (67.54%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL++SMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K   +R +Y  L++H   T
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSADFVDFTSQCLKKNSKERPTYPELMQHPFFT 315
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k3 (mitogen-activated protein kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346868])

HSP 1 Score: 305.834 bits (782), Expect = 8.945e-101
Identity = 164/357 (45.94%), Postives = 227/357 (63.59%), Query Frame = 3 
Query:   63 RGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +G S R++  R     + +S+P   +PT P+               +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ +K+ K  IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   16 KGKSKRKKDLR----ISCVSKPPVSNPTPPR---------------NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMK--IPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPS-PQLPADQ-FSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 343
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k6 (mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870])

HSP 1 Score: 293.123 bits (749), Expect = 1.900e-96
Identity = 149/283 (52.65%), Postives = 194/283 (68.55%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQ 995
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL++SMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQ
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSADFVDFTSQ 293
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k4 (mitogen-activated protein kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346869])

HSP 1 Score: 280.796 bits (717), Expect = 2.342e-90
Identity = 135/273 (49.45%), Postives = 190/273 (69.60%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFY---HKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            +D++ + ++G G YG V KM HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY   + + D      IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S +  +F++ CL K +S R  Y  L++H  +
Sbjct:   98 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD----VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 365
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k7 (mitogen-activated protein kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346871])

HSP 1 Score: 231.106 bits (588), Expect = 1.063e-71
Identity = 119/305 (39.02%), Postives = 184/305 (60.33%), Query Frame = 3 
Query:  162 SIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERIN-PDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            S++ + +  K    +     + + G +    I D+E++ ++G G  G V KMR + +  I AVK++R S N +E +R+L DL++ ++S  CPY+V  +G      DV+I MEL+ +  +K   +++       IPER+L  +T  +V AL YL  +  VIHRDVKPSN L+D+RG++K+CDFGISG L++S AKT + G   Y+APERI+ PDP+   Y IR+DVWSLG+S++ELA  +FPY    + F+ L  V+  + PP LP    +S   + F+  CL K    R  Y+ L+EH  +  ++
Sbjct:   13 SMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP-----IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEE-PPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYE 311
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|Q5E9X2|MP2K6_BOVIN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Bos taurus OX=9913 GN=MAP2K6 PE=2 SV=1)

HSP 1 Score: 313.538 bits (802), Expect = 5.235e-103
Identity = 165/329 (50.15%), Postives = 215/329 (65.35%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K   +R +Y  L++H   T       L ESK T  A +   +L
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIVELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSEEFVDFTSQCLKKNSKERPTYPELMQHPFFT-------LHESKATDVASFVKSIL 332
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|P52564|MP2K6_HUMAN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1)

HSP 1 Score: 312.768 bits (800), Expect = 9.400e-103
Identity = 164/330 (49.70%), Postives = 214/330 (64.85%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVLLG 1136
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K   +R +Y  L++H   T       L ESK         ++LG
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT-------LHESKGTDVASFVKLILG 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|P70236|MP2K6_MOUSE (Dual specificity mitogen-activated protein kinase kinase 6 OS=Mus musculus OX=10090 GN=Map2k6 PE=1 SV=1)

HSP 1 Score: 310.457 bits (794), Expect = 7.950e-102
Identity = 157/305 (51.48%), Postives = 206/305 (67.54%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            PQT S  P  L  KA  S+ +            V   D+E I +LG G YGVVEKMRH PS  I AVK+IR ++N +EQ+RLL DL++SMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY ++ DK     IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K   +R +Y  L++H   T
Sbjct:   23 PQTSSTPPRDLDSKACISIGNQN--------FEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADK-FSADFVDFTSQCLKKNSKERPTYPELMQHPFFT 315
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|O09110|MP2K3_MOUSE (Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus OX=10090 GN=Map2k3 PE=1 SV=2)

HSP 1 Score: 305.834 bits (782), Expect = 6.257e-100
Identity = 164/357 (45.94%), Postives = 227/357 (63.59%), Query Frame = 3 
Query:   63 RGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +G S R++  R     + +S+P   +PT P+               +L   T + +      V   D+ +I +LG G YGVVEK+RH  S  I AVK+IR ++N +EQ+RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ +K+ K  IPE +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K  ++R SY  L+EH   T  K +      KT  A +  ++L
Sbjct:   16 KGKSKRKKDLR----ISCVSKPPVSNPTPPR---------------NLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMK--IPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPS-PQLPADQ-FSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTK------KTDIAAFVKEIL 343
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|Q9DGE0|MP2K6_DANRE (Dual specificity mitogen-activated protein kinase kinase 6 OS=Danio rerio OX=7955 GN=map2k6 PE=1 SV=2)

HSP 1 Score: 303.908 bits (777), Expect = 6.244e-99
Identity = 149/287 (51.92%), Postives = 200/287 (69.69%), Query Frame = 3 
Query:  204 LSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            L     V +      V   D+E I +LG G YGVV+KMRH PS +I AVK+IR ++N +EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY ++ +K     IPE +L  IT  +V ALE+LH  L VIHRDVKPSN LI+ +G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP D  +S     F SQCL K  ++R +Y  L++H   T
Sbjct:   60 LDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-PQLPADR-FSADFVDFTSQCLRKNSTERPTYTELMQHPFFT 342
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A0X3PTZ8 (Dual specificity mitogen-activated protein kinase kinase 6 OS=Schistocephalus solidus OX=70667 GN=MP2K6 PE=3 SV=1)

HSP 1 Score: 335.109 bits (858), Expect = 8.425e-109
Identity = 164/324 (50.62%), Postives = 227/324 (70.06%), Query Frame = 3 
Query:   87 KNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            K RPPA +N     G  +P       I PV +       L++ T+V V   ++T+   +M  + +LG+GQ+  V+KM H PS  +FAVK++       ++ R+LND NISMR++KCPY ++SYGA+   G++WI MEL+D+SLDKF  K+ +K+    IPE LLAYITFC+VTALEYLH++LHVIHRDVKPSN L+D+ GRVKVCDFGISG+L NS+AK+NIG+  YLAPERI+P     G+ I+SDVWSLGL++LELA  +FPY  + ++F QL+ VV  + PP LP+DS YS  +R FI+ CL+K ++ RA+Y  L+E + +
Sbjct:   11 KKRPPALKNFAI--GHHAPGI-----ILPVEIAPGT--KLTNETDVIVGEKQVTIRANEMRLVSELGQGQFAYVQKMVHDPSGCVFAVKRLPFHSETPDRSRILNDYNISMRTSKCPYAIMSYGALSYVGEIWIVMELMDASLDKFLEKVYEKE--EIIPENLLAYITFCVVTALEYLHKDLHVIHRDVKPSNILVDRLGRVKVCDFGISGELTNSLAKSNIGTHNYLAPERIDPLQGTQGFRIQSDVWSLGLTLLELATGEFPYGNFPNVFSQLQQVVKQE-PPKLPSDSPYSEDLRSFIADCLVKDETQRANYVTLLESKFI 322
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: D6WX74 (Dual specificity mitogen-activated protein kinase kinase hemipterous-like Protein OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC005618 PE=3 SV=1)

HSP 1 Score: 326.635 bits (836), Expect = 8.497e-106
Identity = 163/314 (51.91%), Postives = 219/314 (69.75%), Query Frame = 3 
Query:  192 AVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            A A+L   T + +      V   D+E I  LG G YG+VEKMRH PS  I AVK+I  ++N +EQ+RLL DL++SMRS+ CPY V  YGA+F+ GDVWICME++D+SLDKFY K+     +  IPE +L  ITF +V+AL YLH  L VIHRDVKPSN LI+++G VK+CDFGISG L++S+AKT + G +PY+APERI+P  + S Y IRSDVWSLG+S++ELA  +FPY RW S F+QLK VV +D PP LP+   ++     FIS+CL KK +DR++Y+ L+ HE L   K      E+ T F+ + +++L
Sbjct:   25 APANLDKRTTITIGDRTFDVEADDLEKIADLGRGAYGIVEKMRHVPSGTIMAVKRIAATVNTQEQKRLLTDLDVSMRSSDCPYTVQFYGALFREGDVWICMEVMDTSLDKFYAKVYKHGRR--IPEEMLGRITFAVVSALHYLHTRLRVIHRDVKPSNILINRQGEVKMCDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPSQYDIRSDVWSLGISLIELATGQFPYPRWGSPFEQLKQVV-TDDPPRLPS-GQFTAEFEDFISRCLQKKYTDRSNYEQLLNHEFLLKHK------ETNTDFSSFISEIL 328
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A1A8J4T1 (Mitogen-activated protein kinase kinase 6 OS=Nothobranchius kuhntae OX=321403 GN=MAP2K6 PE=3 SV=1)

HSP 1 Score: 318.931 bits (816), Expect = 1.168e-102
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3 
Query:  138 SPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTP-PALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
             P  P+   I P A+       L     V++    + V   D+E I +LG G YGVVEKMRH PS +I AVK+IR ++N  EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ +K     IPE +L  IT  +V ALE+LH  L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINPD +  GYS++SD+WSLG++++ELAI KFPY  W + F QLK VV  D P P LP +  YS     FISQCL K  S+R +Y  L++H+  T       L +SK T  A +  D+L
Sbjct:   13 GPKLPRDAFIPPEAVPAPP-RDLDTKARVKIGDRNVVVEADDLEQIEELGRGAYGVVEKMRHVPSGVIMAVKRIRATVNTLEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKKVIEKG--KTIPEDILGKITVAIVKALEHLHHNLAVIHRDVKPSNVLINTEGQVKMCDFGISGHLVDSVAKTMDAGCKPYMAPERINPDLNQKGYSVKSDIWSLGITMVELAILKFPYDSWRTPFQQLKQVV--DEPSPQLPAEC-YSPEFVDFISQCLRKTPSERPAYTELMKHQFFT-------LHDSKETNVASFVKDIL 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A1D2MGN2 (Dual specificity mitogen-activated protein kinase kinase 6 OS=Orchesella cincta OX=48709 GN=Ocin01_14611 PE=3 SV=1)

HSP 1 Score: 318.546 bits (815), Expect = 1.844e-102
Identity = 158/288 (54.86%), Postives = 204/288 (70.83%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            +L   T + +    + VA  D+E I +LG G YGVVEKMRH+PS  I AVK+I  + N  EQ+R+L DL+ISMRS  CP+ V  YGA+F+ GDVWICME++D SLDK Y  +  ++    IPE +L+ ITF +V AL+YLH EL VIHRDVKPSN LI + GR+K+CDFGISG L NS+AKT ++G +PY+APERI+     S Y +RSDVWSLG+S++ELA   FPY RW + FDQLK VV  D PP+LPND  YS  ++ FI QCL K  +DR SY VL++H  ++
Sbjct:   27 NLDKSTTITIEDRTVAVAADDLEVISELGRGAYGVVEKMRHRPSGTIMAVKRIPATDNYIEQKRVLMDLDISMRSANCPFTVQFYGALFREGDVWICMEVMDISLDKLYPAVFRQNNTG-IPEDILSKITFAVVKALQYLHTELKVIHRDVKPSNILISRDGRIKLCDFGISGYLQNSVAKTIDVGCKPYMAPERIDVMGDTSNYDVRSDVWSLGISLVELATANFPYERWGTPFDQLKQVVTGD-PPSLPNDMGYSPEIQDFIRQCLKKCYTDRPSYSVLLQHPFIS 312
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A1A8V7U9 (Mitogen-activated protein kinase kinase 6 OS=Nothobranchius furzeri OX=105023 GN=MAP2K6 PE=3 SV=1)

HSP 1 Score: 317.775 bits (813), Expect = 3.271e-102
Identity = 169/334 (50.60%), Postives = 220/334 (65.87%), Query Frame = 3 
Query:  138 SPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTP-PALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK-TRFAEYATDVL 1130
             P  P+   I P A+       L     V++    + V   D+E I +LG G YGVVEKMRH PS +I AVK+IR ++N  EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY K+ +K     IPE +L  IT  +V ALE+LH  L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINPD +  GYS++SD+WSLG++++ELAI KFPY  W + F QLK VV  D P P LP +  +S     FISQCL K  S+R +Y  L++H+  T       L +SK T  A +  D+L
Sbjct:   13 GPKLPRDAFIPPEAVPAPP-RDLDTKARVKIGDQNVVVEADDLEQIEELGRGAYGVVEKMRHVPSGVIMAVKRIRATVNTLEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKKVIEKG--KTIPEDILGKITVAIVKALEHLHHNLAVIHRDVKPSNVLINTEGQVKMCDFGISGHLVDSVAKTMDAGCKPYMAPERINPDLNQKGYSVKSDIWSLGITMVELAILKFPYDSWRTPFQQLKQVV--DEPSPQLPAEC-FSPEFVDFISQCLRKTPSERPAYTELMKHQFFT-------LHDSKETNVASFVKDIL 333
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940])

HSP 1 Score: 280.796 bits (717), Expect = 9.156e-91
Identity = 143/326 (43.87%), Postives = 207/326 (63.50%), Query Frame = 3 
Query:  105 FRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNK-ITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            F N   +P T  P    T S Q   +      S+    +++++  +      +D++ + ++G G YG V KM HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY  +        IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S    +F++ CL K +S R  Y  L++H  +  ++
Sbjct:   13 FANPPIKPNTRLPIASSTPSFQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVY-CSLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFIQMYE 336
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103045018])

HSP 1 Score: 282.337 bits (721), Expect = 1.281e-90
Identity = 139/294 (47.28%), Postives = 196/294 (66.67%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +D++ + ++G G YG V KM HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +SLDKFY  +     +  IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S    +F++ CL K +S R  Y  L++H  +  +      +E     A Y   +L
Sbjct:  123 EDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVEFYGALFREGDCWICMELMSTSLDKFYKYVYST-LEDVIPEEILGKITLVTVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLSNSEERQFSPKFINFVNLCLTKDESKRPKYRELLKHPFILMY------EERSVDVASYVCRIL 408
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940])

HSP 1 Score: 280.796 bits (717), Expect = 3.336e-90
Identity = 143/326 (43.87%), Postives = 207/326 (63.50%), Query Frame = 3 
Query:  105 FRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNK-ITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            F N   +P T  P    T S Q   +      S+    +++++  +      +D++ + ++G G YG V KM HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY  +        IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S    +F++ CL K +S R  Y  L++H  +  ++
Sbjct:   63 FANPPIKPNTRLPIASSTPSFQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVY-CSLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFIQMYE 386
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940])

HSP 1 Score: 280.796 bits (717), Expect = 4.284e-90
Identity = 143/326 (43.87%), Postives = 207/326 (63.50%), Query Frame = 3 
Query:  105 FRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNK-ITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            F N   +P T  P    T S Q   +      S+    +++++  +      +D++ + ++G G YG V KM HKPS  I AVK+IR ++++KEQ++LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY  +        IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S    +F++ CL K +S R  Y  L++H  +  ++
Sbjct:   74 FANPPIKPNTRLPIASSTPSFQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVY-CSLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGD-PPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFIQMYE 397
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239])

HSP 1 Score: 271.166 bits (692), Expect = 2.041e-87
Identity = 133/245 (54.29%), Postives = 178/245 (72.65%), Query Frame = 3 
Query:  249 VAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLA--------YITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPND 956
            V   D+E I +LG G YGVV+KMRH PS +I AVK+IR ++N +EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY ++ +K     IPE +L          +   +V ALE+LH  L VIHRDVKPSN LI+ +G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI +FPY  W + F QLK VV  +  P LP D
Sbjct:   48 VKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGRCVISVTVLLNVQIVKALEHLHSRLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV-EEPSPQLPAD 289
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239])

HSP 1 Score: 296.59 bits (758), Expect = 8.456e-98
Identity = 152/308 (49.35%), Postives = 206/308 (66.88%), Query Frame = 3 
Query:  138 SPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            SPT P      P  L  KA  ++ D            V   D+ESI +LG G YGVVE++RH PS  I AVK+IR ++N +EQ+RLL DL+ISMR+  CPY V  YGA+F+ GDVWICMEL+D+SLDKFY K+ +K     IPE +L  I+  +V ALE+LH +L VIHRDVKPSN LI+ +G VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI KFPY  W + F QLK VV   +P   P +  +S     F + CL K  ++R +Y  L+++   
Sbjct:   38 SPTRP------PRDLDSKACITIDDKN--------FEVKADDLESICELGRGAYGVVERVRHTPSGTIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPYTVTFYGALFREGDVWICMELMDTSLDKFYKKVIEKG--LTIPEDILGKISVAIVKALEHLHSKLSVIHRDVKPSNVLINTQGHVKMCDFGISGYLVDSVAKTLDAGCKPYMAPERINPEINQKGYNVKSDIWSLGITMIELAILKFPYESWGTPFQQLKQVVEEPSPQLPPEN--FSPEFVDFSTLCLKKNPNERPTYAELMDNTFF 327
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k4b (mitogen-activated protein kinase kinase 4b [Source:ZFIN;Acc:ZDB-GENE-080721-13])

HSP 1 Score: 278.87 bits (712), Expect = 8.065e-91
Identity = 145/327 (44.34%), Postives = 206/327 (63.00%), Query Frame = 3 
Query:   96 PPAFR---NLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            PP+ +    +I  P    P  P  E ++  ++       LS        G +      D++ + ++G G YG V KM+H  S+ I AVK+IR ++++KEQ++LL DL++ M S+ CPY+V  +GA+F+ GD WICMEL+ +S DKFY K         IPE +L  IT   V AL YL   L +IHRDVKPSN L+D+RG +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG++++ELA  KFPY +WNS+FDQL  VV  D PP L N  +  +S +  +F++ CL K +S R  Y  L++H  +
Sbjct:   15 PPSCKAAPKIIFNPQQVVPNNPHIERLRTHSMESAGKLKLSP-------GQQYDFTADDLKDLGEIGRGAYGSVNKMQHNHSAHIMAVKRIRSTVDEKEQKQLLMDLDVVM-SSDCPYIVQFFGALFREGDCWICMELMSTSFDKFY-KFVYCTSDDVIPEEILGKITLATVKALNYLKENLKIIHRDVKPSNILLDRRGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLIELATGKFPYPKWNSVFDQLTQVVKGD-PPQLSNSEERQFSASFINFVNSCLTKDESRRPKYRELLKHPFI 331
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k7 (mitogen-activated protein kinase kinase 7 [Source:ZFIN;Acc:ZDB-GENE-090312-186])

HSP 1 Score: 248.054 bits (632), Expect = 1.107e-78
Identity = 134/330 (40.61%), Postives = 198/330 (60.00%), Query Frame = 3 
Query:   75 GRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERIN-PDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            G  Q    P FR  +  P +   +TP+  S++ V +  K    ++    + ++G +    I ++E++ ++G G  G V KMR+KP+S I AVK++R S N  E +R+L DL++ ++S  CPY+V  +G+     DV+I MEL+ +  +K   +I+       IPE +L  +T  +V AL YL  +  VIHRDVKPSN L+D RGR+K+CDFGISG L++S AKT   G   Y+APERI+ PDP+   Y IR+DVWSLG+S++ELA  +FPY    + F+ L  V+  D PP LP+D  +S   + F+  CL K    R  Y+ L+EH  L
Sbjct:   15 GHTQHGTVPRFRQTLQLPPSSYGSTPR--SLESVEIDQKLQEIMNQTGFLTLDGKRYRADISELETLGEMGSGTCGQVWKMRYKPTSHILAVKQMRRSGNKDENKRILMDLDVVLKSHDCPYIVQCHGSFITNTDVFIAMELMGTCAEKLKKRIQGP-----IPENILGKMTVAIVKALSYLKEKHGVIHRDVKPSNILLDSRGRIKLCDFGISGRLVDSKAKTRGAGCAAYMAPERIDPPDPTHPDYDIRADVWSLGISLVELATGQFPYQNCKTDFEVLTKVLQED-PPLLPSDMGFSLDFQAFVKDCLTKDHRKRPKYNKLLEHAFL 336
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004725.1 (pep scaffold:Pmarinus_7.0:GL477683:141377:157028:-1 gene:ENSPMAG00000004255.1 transcript:ENSPMAT00000004725.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 172.94 bits (437), Expect = 1.712e-50
Identity = 84/207 (40.58%), Postives = 132/207 (63.77%), Query Frame = 3 
Query:  261 DMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFP 878
            D E + +LG G  GVV K+ HKPS+LI A K I   +    + +++ +L + +     PY+V  YGA +  G++ ICME +D  SLD    K         IPE +L  ++  ++  L YL  +  ++HRDVKPSN L++ RG +K+CDFG+SG LI+SMA + +G++ Y++PER+     G+ YS++SD+WS+GLS++E+AI ++P
Sbjct:   45 DFEKLSELGAGNGGVVTKVLHKPSALIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDLVLKK------AGRIPEEILGKVSIAVIKGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ----GTHYSVQSDIWSMGLSLVEMAIGRYP 240
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 114.39 bits (285), Expect = 1.860e-27
Identity = 79/267 (29.59%), Postives = 129/267 (48.31%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTN--IGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEH 1049
            +D E   +LG G YG V K R+  +  + A+K I+    D     ++    + M+  K   +V  YG+  +   +WICME     SL   YH          + ER +AY+T   +  L YLH E   +HRD+K +N L+   G VK+ DFG+S  +  ++AK    IG+  ++APE    +  G GY+ + DVW++G++ +ELA  + P    + +        +   PP L +   +S    +FI   L K    R + + ++ H
Sbjct:   12 EDFELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFS--VIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGP------LTERQIAYVTRETLQGLAYLHSE-GKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKG-GYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTH 268
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: PBS2 (MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003664])

HSP 1 Score: 220.705 bits (561), Expect = 1.942e-65
Identity = 119/305 (39.02%), Postives = 189/305 (61.97%), Query Frame = 3 
Query:  231 NGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLID-KRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINP-DPSGSGYSIRSDVWSLGLSVLELAICKFPY--SRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            NG+   + + ++E + +LG G YG V K+ HKP+++I A K++R  +++ + R++L +L + +     PY+V  YGA F  G V++CME +D  SLDK Y +  +      I E  LA+I   ++  L+ L  + ++IHRDVKP+N L    +G VK+CDFG+SG+L+ S+AKTNIG Q Y+APERI   +P  + Y+++SD+WSLGLS+LE+A+ ++PY    ++++F QL  +V    PP LP+D  +S+  + F+S CL K    R +Y  L EH  L  ++N+          +EY T+ L
Sbjct:  349 NGSSSRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEV-LHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEI---GGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIV-DGPPPRLPSDK-FSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQ------DVHMSEYITERL 641
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: STE7 (Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway [Source:SGD;Acc:S000002318])

HSP 1 Score: 178.333 bits (451), Expect = 6.757e-51
Identity = 112/330 (33.94%), Postives = 177/330 (53.64%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQ-RRLLNDLNISMRSTKCPYVVISYGAMFQ---GGDVWICMELLD-SSLDK-------FYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDV---VASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML----TPFKNEKY 1082
            P  ES+ P A      A L D      NGN I   ++D+  + K+G G  G V K  H P S I A K I    N+     +L+ +L+I         ++  YGA +      ++ I ME  D  SLDK       F  +      K +  E  ++ I + ++  L++L+R+  +IHRD+KPSN LI+ +G++K+CDFG+S  LINS+A T +G+  Y++PERI     G+ YSI+ DVWSLGL ++EL   +FP    N   D + D+   + ++  P LP D  YS  +  F+++C IK + +R+S   L+ H+++    +P K++K+
Sbjct:  161 PLEESLSPAA------ADLKDTLSGTSNGNYI--QLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERI----QGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKF 478
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 158.303 bits (399), Expect = 1.488e-43
Identity = 111/303 (36.63%), Postives = 161/303 (53.14%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKE-QRRLLNDLNISMRSTKCPYVVISYGAMF---QGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSR--------------WNSLFD-QLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEH 1049
            S+ D  ++  NG K       +E++  LGEG  G V K + K  S IFA+K I     D E Q+++  +L  + RS +  Y+V  YG MF   +   ++I ME +   SLD  Y  + ++  +  I E++L  I   ++  L YLH E  VIHRD+KP N L+++ G+VK+CDFG+SG+ +NS+A T  G+  Y+APERI   P    YS+ SDVWSLGL++LE+A  KFP S               W   F  +LKD   S+          +S + + FI  CL K   +R S   +I H
Sbjct:  200 SVRDVDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFN-RSFQSEYIVRYYG-MFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR--ISEKVLGKIAEAVLRGLSYLH-EKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQP----YSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNI--------IWSPSFKSFIDYCLKKDSRERPSPRQMINH 485
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061])

HSP 1 Score: 154.451 bits (389), Expect = 3.717e-42
Identity = 101/277 (36.46%), Postives = 155/277 (55.96%), Query Frame = 3 
Query:  261 DMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKE-QRRLLNDLNISMRSTKCPYVVISYGAMF---QGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSR----WNSLFDQLKDVVASDTP-----PALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEH 1049
            ++ ++  LGEG  G V K R K    +FA+K I     D E Q+++  +L  + +S K  Y+V  YG MF   Q   ++I ME +   SL+  Y  +  +  +  I ER++  I   ++  L YLH E  VIHRD+KP N L++++G +K+CDFG+SG+ +NS+A T  G+  Y+APERI   P    YS+  DVWSLGL++LE+A  +FP+       N    +L  ++ + +P     P L  D ++S T R FI  CL K   +R S   +++H
Sbjct:  213 EITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFN-KSFKSDYIVQYYG-MFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR--ISERVIGKIAESVLRGLSYLH-ERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQP----YSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPEL--DISWSKTFRSFIDYCLKKDARERPSPRQMLKH 478
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 108.997 bits (271), Expect = 9.699e-26
Identity = 78/277 (28.16%), Postives = 136/277 (49.10%), Query Frame = 3 
Query:  261 DMESIHK----LGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICME-LLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDL-INSMAKTNIGSQPY-LAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFK 1070
            D+ S+ K    +G G++GVV K  +  +  ++A+K +    +  E   +  ++       +   +   YG+  +   +WI ME     SL       K       I E+ +  I   L+ AL+ +H++ +VIHRD+K +N LI   G VK+CDFG++  +   S+ +  +   PY +APE I     G  Y  + D+WSLG++  E+A    PY    +L  +   ++    PP L  D +YS +++ FI+ CL +   +R S D L++ + +   K
Sbjct:   18 DVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-------IDEKYIGVIMRELLVALKCIHKD-NVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIM---EGVYYDTKVDIWSLGITTYEIATGNPPYCDVEAL--RAMQLIIKSKPPRL-EDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHK 280
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO38062 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDX6])

HSP 1 Score: 295.049 bits (754), Expect = 3.909e-97
Identity = 146/287 (50.87%), Postives = 199/287 (69.34%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            +LSD T + V G +      D++ I +LG G YG V +M H P+S + AVKKIR ++N  EQ+RLL DL+ISMR +  PY V  YGA+F+ GDVWICMEL+ +SL   Y ++  K P   IPE +L  I   +V+ALEYLH  L VIHRDVKPSN L+D+RG  K+CDFGISG L++S+AKT + G +PY+APERINPD    GY IRSD+WSLG++++ELA  KFPY++W + F+QLK VV   + P+LP +  +S   R F+++ LIK   +R +Y+ L+EH  +
Sbjct:   37 NLSDKTTITVGGQEFDCQADDLQEIRELGHGAYGYVYEMLHVPTSTVMAVKKIRANVNSTEQKRLLMDLDISMRVSDYPYTVHFYGALFREGDVWICMELMKTSLYDLYKQVFSK-PDRRIPEEVLGKIAVSVVSALEYLHSNLKVIHRDVKPSNILVDERGNFKLCDFGISGQLVDSLAKTVDAGCKPYMAPERINPDRDMKGYDIRSDIWSLGITMIELATGKFPYTQWKTPFEQLKQVVHEPS-PSLP-EGPFSLNFRDFVTKSLIKNYKERPNYNQLLEHPFI 320
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO48408 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJN6])

HSP 1 Score: 264.233 bits (674), Expect = 1.272e-85
Identity = 131/285 (45.96%), Postives = 191/285 (67.02%), Query Frame = 3 
Query:  261 DMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNE-----KYLQE 1091
            D+    ++G G YG V KM H  S+   AVK+IR +++ K+Q++LL DL++ MRS+ CP++V  YGA+F  GD WICMEL++ S DK Y K+     +  IPE +L+ + + +V AL+YL REL++IHRDVKPSN L+D+ G +K+CDFGISG L++S+AKT + G +PY+APERI+P     GY IRSDVWS G++++EL+   FPY +WNS+FDQL  VV  D PP L N  +   S  + +F++ CL K+   R  Y+ L+ H+ +  ++        +LQE
Sbjct:    8 DLVDCGEIGRGAYGTVNKMLHPNSNTFMAVKRIRSTVDQKDQKQLLMDLDVVMRSSNCPFIVRFYGALFTEGDAWICMELMEISFDKCY-KLVYGSIEQIIPEEILSKVAYAVVKALDYLKRELNIIHRDVKPSNILLDRNGAIKLCDFGISGHLVDSIAKTRDAGCKPYMAPERIDPSSCRQGYDIRSDVWSFGITMIELSTGVFPYPKWNSVFDQLSQVVDGD-PPQLSNTPEMMRSPELLNFVNICLSKEVEKRPKYNELLNHQFIQLYQERPVDVGAWLQE 290
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO43384 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYU8])

HSP 1 Score: 229.565 bits (584), Expect = 5.406e-72
Identity = 122/298 (40.94%), Postives = 182/298 (61.07%), Query Frame = 3 
Query:  222 VQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERIN-PDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEK-----YLQES 1094
            +++   K   ++ D+E   ++G G  G V KM+HK S  + AVK++  S N +EQ+R+L DL + M+S  CPY+V   GA+    DV+ICMEL+ + LDK   ++++      IPE +L  +   +V AL YL  E  V+HRDVKPSN L+D  G VK+CDF ISG L++S AKT + G   Y+APERI+ PDP    Y +R+DVWSLG+S++ELA  +FPY    + F+ L  V+  D PP+LP    +S+    F+ +CL K    R  Y+ L+ H  +T + +++     +L+ES
Sbjct:   29 LKLGDKKYDFSLDDLEMSGEIGYGTCGQVCKMKHKKSGQVLAVKRMARSHNKEEQKRILMDLEVVMKSHDCPYIVTCMGALISKSDVFICMELMATCLDKLLKRLQNP-----IPEHILGKMAVAIVKALHYLKEEHGVMHRDVKPSNMLLDSAGCVKLCDFSISGRLVDSKAKTKSAGCAAYMAPERIDPPDPMNPNYDVRADVWSLGISLVELATGEFPYRNCTTEFEVLTRVMGED-PPSLPGSKGFSHDFSSFVDECLTKDFHYRPKYNKLLVHPFITSYDSKEVDVAGWLKES 320
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO45553 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSF4])

HSP 1 Score: 175.637 bits (444), Expect = 6.376e-51
Identity = 111/333 (33.33%), Postives = 175/333 (52.55%), Query Frame = 3 
Query:  261 DMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELH-VIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPY-----------------------------------------SRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            D E I +LG G  GVV K+ HKP+ LI A K I   +    + +++ +L + +     PY+V  +GA +  G++ ICME +D  SLD    K         IPE +L  I+  ++  L YL RE+H +IHRDVKPSN L++ RG +K+CDFG+SG LI+SMA + +G++ Y++PER+     G+ Y+I+SD+WS GLS++E+AI ++P                                          +R  ++F+ L D + ++ PP LP  + +S     F+ +CL+K    RA    L+ H+ +   K +K    S   FA++ +  L
Sbjct:   38 DFEKITELGAGNGGVVTKVLHKPTGLIMARKLIHLEVKPAIRTQIIRELKV-LHDCNSPYIVGFFGAFYSDGEISICMEHMDGGSLDLILKK------AGRIPEDILGKISIAVLKGLCYL-REIHQIIHRDVKPSNILVNSRGEIKMCDFGVSGQLIDSMANSFVGTRSYMSPERLQ----GNQYTIQSDIWSFGLSLVEMAIGRYPIPPPDPQEIEKVLSREPSSMASPMSVGRLPPGVRPPSGVNNETRPMAIFELL-DYIVNEPPPILPG-AHFSPEFCEFVQKCLVKNPKQRADLTYLMTHKFIA--KADK----SNVDFAKWISQFL 350
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO40740 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6F5])

HSP 1 Score: 166.007 bits (419), Expect = 2.485e-46
Identity = 108/321 (33.64%), Postives = 165/321 (51.40%), Query Frame = 3 
Query:  132 TDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDS-SLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSR-----------WNSLF---DQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEH 1049
            T +P +P  ++  P  +        +    +   G      I+ +E    LG G  G V K  H  +  I AVK I   +  + QR++++++ IS +    PY++  YGA F    + +C E +D  SLD +            IPE +L  I   +V  L YL   L ++HRDVKPSN L++ RG+VK+CDFG+S  L+NS+A T +G+  Y+APERI     G  YSI S+VWSLG+S+LE+A  +FPY +            N  F    +L   +  + PP LP D  +S     F++QC+ K  S R + + +++H
Sbjct:  112 TRAPLSPSGQTSMPAPMNSHLQHQPTTAPSILAGGQLNQEQIQHLE---ILGYGNGGTVYKAIHLTTRRIIAVKVIPLDVTPEVQRQIISEMEISFQCAS-PYIIEFYGAFFVENRISMCTEYMDGGSLDMY----------GSIPEPVLGRIAVAVVKGLAYLW-GLKIMHRDVKPSNILVNTRGQVKLCDFGVSRQLVNSIATTYVGTNAYMAPERI----LGDEYSILSEVWSLGVSLLEMASGRFPYLKVSIQLASYFFFGNHCFLVPIELLQCIVHEAPPRLP-DHLFSPVFVDFVAQCMQKSPSTRLTPEAVLDH 412
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: MAP2K6 (dual specificity mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:101170843])

HSP 1 Score: 305.834 bits (782), Expect = 5.328e-101
Identity = 156/310 (50.32%), Postives = 203/310 (65.48%), Query Frame = 3 
Query:  138 SPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTP-PALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
             P  P+   + P          L     V +      V   D+E I +LG G YGVV+KM+H P+++I AVK+IR ++N  EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY  + +K     IPE +L  I   +V ALE+LHR L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT + G +PY+APERINPD +  GYS++SD+WSLG++++ELAI KFPY  W + F QLK VV  D P P LP D  +S     FISQCL K   +R +Y  L+ H   T
Sbjct:   13 GPKLPKEVFMSPQPTAAAPPRDLDSKACVTIGDQNFVVKADDLEQIEELGRGAYGVVDKMKHVPTNVIMAVKRIRATVNTLEQKRLLMDLDISMRTVDCHYTVTFYGALFREGDVWICMELMDTSLDKFYKNVIEKGKT--IPEDILGKIAVAIVKALEHLHRNLSVIHRDVKPSNVLINTLGQVKMCDFGISGHLVDSVAKTMDAGCKPYMAPERINPDLNQKGYSVKSDIWSLGITMIELAILKFPYDSWGTPFQQLKQVV--DEPSPQLPADR-FSPEFVDFISQCLRKAPRERPAYTELMNHSFFT 317
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k6 (dual specificity mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:101163933])

HSP 1 Score: 301.212 bits (770), Expect = 6.073e-99
Identity = 152/305 (49.84%), Postives = 205/305 (67.21%), Query Frame = 3 
Query:  150 PQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLT 1061
            P   ++ P  L  KA  ++ +         K  V   D+E I +LG G YGVV+KMRH PS LI AVK+IR ++N +EQ+RLL DL+ISMR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY ++ +K     IPE +L  I   +V ALE+LH  L VIHRDVKPSN LI+ +G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ +  GY+++SD+WSLG++++ELAI +FPY  W + F QLK VV   + P LP    +S     F SQCL K   +R +Y  L++H   T
Sbjct:   47 PAPAAVPPRDLDSKACVTIGE--------KKCEVKADDLEQICELGRGAYGVVDKMRHVPSGLIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVIEKG--LTIPEDILGKIAVSIVKALEHLHSNLQVIHRDVKPSNVLINTQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYESWGTPFQQLKQVVEEPS-PQLPA-GQFSPEFVDFTSQCLRKVSKERPTYTELMQHPFFT 339
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101174917])

HSP 1 Score: 275.789 bits (704), Expect = 2.753e-88
Identity = 134/265 (50.57%), Postives = 187/265 (70.57%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLI 1043
            +D++ + ++G G YG V KM HKPS+ I AVK+IR ++++KEQ++LL DL++ +RS+ CPY+V  YGA+F+ GD WICMEL+ +SLDKFY K         IPE +L  IT   V AL +L   L +IHRD+KPSN L+D++G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S     F++ CL K++S R  Y  L+
Sbjct:  112 EDLKDLGEIGRGAYGSVNKMVHKPSNQIMAVKRIRSTVDEKEQKQLLMDLDVVVRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFY-KFVYCSLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVRGD-PPQLSNSDERRFSPKFISFVNVCLTKEESKRPKYRELL 374
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101161098])

HSP 1 Score: 275.789 bits (704), Expect = 3.008e-88
Identity = 133/270 (49.26%), Postives = 186/270 (68.89%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEML 1058
            +D+  + ++G G YG V KM HKP+  I AVK+IR ++ +KEQ++LL DL++ MRS+ C Y+V  YGA+F+ GD WICMEL+ +SLDKFY  +        IPE +L  IT   V AL +L   L +IHRD+KPSN L+D+RG +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  + PP L N  +  +S    +F++ CL K +S R  Y  L++H  +
Sbjct:  108 EDLRDLGEIGRGAYGSVNKMVHKPTGQIMAVKRIRSTVEEKEQKQLLMDLDVVMRSSDCLYIVQFYGALFREGDCWICMELMSTSLDKFYKYVYCALDDV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILMDRRGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGE-PPQLSNSEERQFSPKFINFVNLCLTKDESKRPKYRELLKHSFI 375
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101174917])

HSP 1 Score: 275.789 bits (704), Expect = 3.581e-88
Identity = 134/265 (50.57%), Postives = 187/265 (70.57%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPN--DSTYSNTVRHFISQCLIKKDSDRASYDVLI 1043
            +D++ + ++G G YG V KM HKPS+ I AVK+IR ++++KEQ++LL DL++ +RS+ CPY+V  YGA+F+ GD WICMEL+ +SLDKFY K         IPE +L  IT   V AL +L   L +IHRD+KPSN L+D++G +K+CDFGISG L++S+AKT + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV  D PP L N  +  +S     F++ CL K++S R  Y  L+
Sbjct:  118 EDLKDLGEIGRGAYGSVNKMVHKPSNQIMAVKRIRSTVDEKEQKQLLMDLDVVVRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFY-KFVYCSLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVRGD-PPQLSNSDERRFSPKFISFVNVCLTKEESKRPKYRELL 380
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000041446.1 (SMESG000041446.1)

HSP 1 Score: 738.413 bits (1905), Expect = 0.000e+0
Identity = 357/362 (98.62%), Postives = 357/362 (98.62%), Query Frame = 3 
Query:   51 MATERGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVLLG 1136
            MATERGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMES     EGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVLLG
Sbjct:    1 MATERGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMES-----EGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVLLG 357
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000040748.1 (SMESG000040748.1)

HSP 1 Score: 434.106 bits (1115), Expect = 2.292e-151
Identity = 206/348 (59.20%), Postives = 267/348 (76.72%), Query Frame = 3 
Query:   87 KNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            K +PP F+    + G           I+PV +    V  L+DHTEVQVNG KIT+++ D+E++++LG+GQ+G+VE+M HKPS+L+FAVK++RCS +DK+Q R+LNDLNISMRST+CPYVV+SYGAM +GGDVWICME+LDSSLDKFY  +     ++FIPE +LAYITFC+VTALEYLH+ L VIHRDVKPSN LIDK GRVKVCDFGISG L+NS+A+TN+G+Q YLAPERI  + S SG++IRSDVWSLGLS+LELAI KFPY    SL++ L   V    PP+LP +S+YSNTVR+FIS+CL+    DRASY  L++H++L  F  + +L+  +  FA Y T +L
Sbjct:    5 KKKPPNFKTFNLKSGI----------IEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYN-LITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 341
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000057661.1 (SMESG000057661.1)

HSP 1 Score: 265.388 bits (677), Expect = 4.297e-85
Identity = 134/292 (45.89%), Postives = 193/292 (66.10%), Query Frame = 3 
Query:  258 KDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 1130
            +D++ + ++G G YG V +M H+ +  + AVK+IR ++++ +Q   LNDL++ M+S  CP++V  YGA+F+ GD WICMEL+ +SLDKFY  +     K  IPE++L  +    V AL+YL  EL VIHRDVKPSN LID+ G +K+CDFGISG LI+S+AK+ + G +PY+APERI+P  S  GY IRSDVWSLG++++EL   KFPY  W S+F+QL  V+  D PP++ +   +S   ++FI +CL K  S R  YD L +H     F N ++ Q      +EY   +L
Sbjct:   52 EDLQDLGEIGRGAYGSVNRMIHRKTDQLMAVKRIRSTLDESQQYSTLNDLDVIMKSANCPFIVRFYGALFREGDCWICMELMSTSLDKFYRYVY-VHLKEKIPEKILGKVAVGTVKALDYLKVELRVIHRDVKPSNVLIDRDGNIKLCDFGISGQLIDSIAKSRDAGCKPYMAPERIHPKLSAKGYDIRSDVWSLGITMIELGTGKFPYPAWESVFEQLTCVLHGD-PPSVNDSMGFSRQFQNFIERCLEKDYSKRPRYDELKQHPF---FINSEFDQ---INVSEYFCKIL 335
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000035167.1 (SMESG000035167.1)

HSP 1 Score: 202.216 bits (513), Expect = 3.740e-61
Identity = 116/302 (38.41%), Postives = 173/302 (57.28%), Query Frame = 3 
Query:  201 SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFIS--QC-LIKKDSDRASYDVLIEHEMLTPFKNEKYLQESK 1097
            +LS+  + +       + + ++  I  LGEG +  V+ M+   + + FAVK    ++ D   + ++ND+ +  +S   P+ +  YG +     +WI ME +D S+  FY KI  KD     P  +L Y ++C V  LE LH +  VIHRDVKPSN LI++ G+ K+CDFGISG L +S+ ++ +G+  YLAPE+I+P   G  YSI SDVWSLGLS+LE+A  KFP+S   +L  QL ++V S +PP LP DS Y       I   QC L+K    R  YD L +  +L  F ++    E++
Sbjct:   10 NLSNRLQCRYKNEDSYIEMDNLLFIKHLGEGNFSTVQLMKDPVTEIEFAVKMFN-NVADNVMKDIMNDIEVG-KSISSPFKIDYYGGLKDPYRIWILMEPMDLSVRLFYEKIISKDKDYRFPGIILGYFSYCSVYVLEDLHLK-QVIHRDVKPSNMLINRSGKFKLCDFGISGKLKDSLVQSAVGTNAYLAPEKIDPKSHGDKYSIISDVWSLGLSILEIADMKFPFSNCKTLMSQLYNIVQS-SPPTLPLDSPYHKQYPDLIKFFQCTLVKDPKQRYRYDKLKKLPLLQSFSDQSKFNEAQ 307
[Close]
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000007331.1 (SMESG000007331.1)

HSP 1 Score: 189.119 bits (479), Expect = 2.116e-53
Identity = 106/277 (38.27%), Postives = 159/277 (57.40%), Query Frame = 3 
Query:  222 VQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKP-SSLIFAVKKIRCSMND-KEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKT-NIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLI 1043
            + +N  KIT  + + E    LG G  G V +MR K   S+  AVK++R S +  +E +R+  DL++  R   CP++V  YG      +VWICME + + LDK    +         PE ++  ++  ++ AL+YL  +  ++HRD+KPSN L+  RG VK+CDFGIS  L +S+A +   G   Y+APER+N     S Y +R+DVWSLG+S++ELAI KFP     S F+ +  ++    PP+LP +  YS     F+S CL K  ++R  YD L+
Sbjct:   59 LTINNEKITTKMDEFEIESSLGHGTCGNVYRMRLKRLPSIPMAVKQMRRSSHSVEENKRIFRDLDVVTRCHDCPFIVTCYGIFISPSEVWICMEEMSTCLDKLLKFLN-----CPFPEYVIGKVSCAIIKALQYLKTKHDIMHRDIKPSNMLLSDRGEVKLCDFGISAKLKDSIANSRQPGCIGYMAPERLN----SSTYDVRADVWSLGMSLVELAIGKFPIDGLKSEFEIMARII-DGKPPSLP-EGVYSEAFNKFVSSCLQKDFNNRPKYDKLV 324
The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP2K61.957e-10349.70mitogen-activated protein kinase kinase 6 [Source:... [more]
MAP2K31.424e-9949.52mitogen-activated protein kinase kinase 3 [Source:... [more]
MAP2K31.424e-9949.52mitogen-activated protein kinase kinase 3 [Source:... [more]
MAP2K31.424e-9949.52mitogen-activated protein kinase kinase 3 [Source:... [more]
MAP2K32.585e-9949.52mitogen-activated protein kinase kinase 3 [Source:... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sek-17.005e-8741.87Dual specificity mitogen-activated protein kinase ... [more]
sek-17.005e-8741.87Dual specificity mitogen-activated protein kinase ... [more]
mkk-46.826e-7647.21MAP kinase kinase mkk-4 [Source:UniProtKB/Swiss-P... [more]
sek-64.697e-6343.85SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:O017... [more]
sek-31.802e-6240.07SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:Q8MP... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lic1.589e-9145.66gene:FBgn0261524 transcript:FBtr0073720[more]
Mkk48.272e-8947.19gene:FBgn0024326 transcript:FBtr0334320[more]
Mkk48.272e-8947.19gene:FBgn0024326 transcript:FBtr0081892[more]
Mkk48.272e-8947.19gene:FBgn0024326 transcript:FBtr0300443[more]
hep5.691e-6641.72gene:FBgn0010303 transcript:FBtr0330397[more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map2k67.743e-10051.92mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k68.272e-10051.92mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k4a2.279e-9048.18mitogen-activated protein kinase kinase 4a [Source... [more]
map2k4a2.822e-9046.26mitogen-activated protein kinase kinase 4a [Source... [more]
map2k4b2.138e-8943.79mitogen-activated protein kinase kinase 4b [Source... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map2k62.884e-9946.94mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k64.078e-9946.94mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k65.457e-9952.03mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k69.336e-9946.94mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k69.799e-9952.03mitogen-activated protein kinase kinase 6 [Source:... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map2k61.137e-10251.48mitogen-activated protein kinase kinase 6 [Source:... [more]
Map2k38.945e-10145.94mitogen-activated protein kinase kinase 3 [Source:... [more]
Map2k61.900e-9652.65mitogen-activated protein kinase kinase 6 [Source:... [more]
Map2k42.342e-9049.45mitogen-activated protein kinase kinase 4 [Source:... [more]
Map2k71.063e-7139.02mitogen-activated protein kinase kinase 7 [Source:... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5E9X2|MP2K6_BOVIN5.235e-10350.15Dual specificity mitogen-activated protein kinase ... [more]
sp|P52564|MP2K6_HUMAN9.400e-10349.70Dual specificity mitogen-activated protein kinase ... [more]
sp|P70236|MP2K6_MOUSE7.950e-10251.48Dual specificity mitogen-activated protein kinase ... [more]
sp|O09110|MP2K3_MOUSE6.257e-10045.94Dual specificity mitogen-activated protein kinase ... [more]
sp|Q9DGE0|MP2K6_DANRE6.244e-9951.92Dual specificity mitogen-activated protein kinase ... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0X3PTZ88.425e-10950.62Dual specificity mitogen-activated protein kinase ... [more]
D6WX748.497e-10651.91Dual specificity mitogen-activated protein kinase ... [more]
A0A1A8J4T11.168e-10250.90Mitogen-activated protein kinase kinase 6 OS=Notho... [more]
A0A1D2MGN21.844e-10254.86Dual specificity mitogen-activated protein kinase ... [more]
A0A1A8V7U93.271e-10250.60Mitogen-activated protein kinase kinase 6 OS=Notho... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map2k4b9.156e-9143.87dual specificity mitogen-activated protein kinase ... [more]
map2k4a1.281e-9047.28mitogen-activated protein kinase kinase 4 [Source:... [more]
map2k4b3.336e-9043.87dual specificity mitogen-activated protein kinase ... [more]
map2k4b4.284e-9043.87dual specificity mitogen-activated protein kinase ... [more]
map2k62.041e-8754.29mitogen-activated protein kinase kinase 6 [Source:... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map2k68.456e-9849.35mitogen-activated protein kinase kinase 6 [Source:... [more]
map2k4b8.065e-9144.34mitogen-activated protein kinase kinase 4b [Source... [more]
map2k71.107e-7840.61mitogen-activated protein kinase kinase 7 [Source:... [more]
ENSPMAT00000004725.11.712e-5040.58pep scaffold:Pmarinus_7.0:GL477683:141377:157028:-... [more]
MAP4K31.860e-2729.59mitogen-activated protein kinase kinase kinase kin... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
PBS21.942e-6539.02MAP kinase kinase of the HOG signaling pathway; ac... [more]
STE76.757e-5133.94Signal transducing MAP kinase kinase; involved in ... [more]
MKK11.488e-4336.63MAPKK involved in the protein kinase C signaling p... [more]
MKK23.717e-4236.46MAPKK involved in the protein kinase C signaling p... [more]
KIC19.699e-2628.16Protein kinase of the PAK/Ste20 family, required f... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO380623.909e-9750.87Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO484081.272e-8545.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO433845.406e-7240.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO455536.376e-5133.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO407402.485e-4633.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP2K65.328e-10150.32dual specificity mitogen-activated protein kinase ... [more]
map2k66.073e-9949.84dual specificity mitogen-activated protein kinase ... [more]
map2k4a2.753e-8850.57mitogen-activated protein kinase kinase 4 [Source:... [more]
map2k4b3.008e-8849.26dual specificity mitogen-activated protein kinase ... [more]
map2k4a3.581e-8850.57mitogen-activated protein kinase kinase 4 [Source:... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000041446.10.000e+098.62SMESG000041446.1[more]
SMESG000040748.12.292e-15159.20SMESG000040748.1[more]
SMESG000057661.14.297e-8545.89SMESG000057661.1[more]
SMESG000035167.13.740e-6138.41SMESG000035167.1[more]
SMESG000007331.12.116e-5338.27SMESG000007331.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004633 ID=SMED30004633|Name=Mitogen-activated protein kinase kinase 6|organism=Schmidtea mediterranea sexual|type=transcript|length=1363bp
TATACAAAATCTTTAATTTGAATTTTTATTAGCTTAAATAGACTCTTCAG
ATGGCTACCGAGAGAGGAGATAGCGGCCGTCGACAGAAAAATCGACCACC
AGCTTTTAGAAATTTAATCTCTGAACCGGGTACAGATTCACCCACGACTC
CTCAAACTGAAAGCATCCAGCCAGTTGCTTTGACTGGAAAGGCAGTTGCA
AGTTTAAGCGATCACACTGAAGTTCAGGTTAATGGAAATAAAATTACAGT
AGCAATCAAAGACATGGAAAGTATCCATAAACTTGGTGAAGGTCAATATG
GAGTAGTGGAAAAAATGAGACACAAACCTTCCAGTTTGATTTTCGCTGTT
AAAAAAATTAGATGTTCGATGAATGATAAAGAACAACGGCGCTTATTAAA
TGACTTAAATATTAGTATGCGCAGTACCAAGTGCCCATATGTCGTTATTA
GTTATGGTGCCATGTTTCAAGGCGGCGACGTTTGGATATGCATGGAATTA
TTAGATTCAAGTCTTGATAAATTTTATCATAAGATCAAAGACAAAGATCC
AAAAGCTTTTATTCCAGAAAGATTATTGGCTTATATTACTTTCTGTCTTG
TTACGGCACTAGAATATTTACATCGAGAACTTCATGTAATCCACAGGGAC
GTTAAGCCCAGTAATACTCTCATTGACAAACGCGGTCGTGTTAAAGTTTG
TGATTTCGGAATATCGGGAGATCTAATAAACTCTATGGCTAAAACAAATA
TCGGCAGTCAACCATATTTGGCACCAGAACGCATAAATCCAGATCCCAGT
GGATCTGGATACAGTATTCGTTCAGATGTTTGGTCTCTTGGTTTATCCGT
GCTTGAATTGGCAATATGCAAATTTCCATATTCGCGATGGAATTCTTTGT
TTGACCAATTGAAAGACGTGGTGGCCAGTGATACACCACCAGCACTTCCA
AATGATTCGACTTATTCGAATACGGTGCGCCATTTTATATCTCAGTGCCT
TATCAAAAAGGATAGTGACCGTGCATCGTATGATGTTCTGATTGAGCATG
AGATGCTGACGCCGTTCAAAAATGAGAAATACTTGCAAGAAAGTAAGACC
CGGTTTGCTGAATATGCAACTGATGTCTTGCTAGGGTAATGGAATTATTT
TGATTAGGAACCATCTATGACTCTGACTGTGTGATTATTTTATGTATGAC
CATCATTCTTCATTGGTCGTCTTCATTGATCGATCACCCGTGACTATTTG
AGAATCAAGTATATATAATAAAATATGATTTTACACTTTTTTAATATAAA
AATATGTTTTAGATCTGTTTTTGAAAATTCAAATTTAAATTTATTAAAAT
AATTTGTCATTTG
back to top

protein sequence of SMED30004633-orf-1

>SMED30004633-orf-1 ID=SMED30004633-orf-1|Name=SMED30004633-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=363bp
MATERGDSGRRQKNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVA
SLSDHTEVQVNGNKITVAIKDMESIHKLGEGQYGVVEKMRHKPSSLIFAV
KKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMEL
LDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRD
VKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPS
GSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALP
NDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKT
RFAEYATDVLLG*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000140anterior region of the whole animal
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 72..336
e-value: 1.3E-57
score: 207.4
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 73..335
e-value: 3.3E-50
score: 170.9
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 72..336
score: 39.085
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 63..150
e-value: 1.4E-32
score: 113.7
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 153..353
e-value: 8.3E-47
score: 161.0
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..37
NoneNo IPR availablePANTHERPTHR44305FAMILY NOT NAMEDcoord: 54..339
NoneNo IPR availablePANTHERPTHR44305:SF4coord: 54..339
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 196..208
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 78..102
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 63..343