Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004608 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 13
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CAMK4 (calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464]) HSP 1 Score: 170.629 bits (431), Expect = 3.378e-48 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 32 YWI-DGSNRDALSDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVRKLIVLDPKKRLTTFQALQHPW 299
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CAMK4 (calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464]) HSP 1 Score: 170.629 bits (431), Expect = 3.378e-48 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 32 YWI-DGSNRDALSDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVRKLIVLDPKKRLTTFQALQHPW 299
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PSKH1 (protein serine kinase H1 [Source:HGNC Symbol;Acc:HGNC:9529]) HSP 1 Score: 152.525 bits (384), Expect = 8.663e-42 Identity = 94/286 (32.87%), Postives = 148/286 (51.75%), Query Frame = 2
Query: 47 RRKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKV--GYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHY--DIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNC-ESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
RR ++ Y K + V YDI I R G+ S V +R TR+ +A+ +I+ K G +++ + ++ N+++++EVFET + ++ E TG +LF+ G +TE R+ + +L G+RYLH I H ++K ENL+ G + I+ I D ++ D + P PEVL+ + T ++DMWA+GV +ILL G PF + T LYR ++ YSY+ S SN KDF++ LL DP +RM + AL+HPW
Sbjct: 79 RRARVAKYRAK---FDPRVTAKYDIKALIGR------GSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKII-ITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPW 354
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CAMK1 (calcium/calmodulin dependent protein kinase I [Source:HGNC Symbol;Acc:HGNC:1459]) HSP 1 Score: 145.591 bits (366), Expect = 1.441e-39 Identity = 83/271 (30.63%), Postives = 145/271 (53.51%), Query Frame = 2
Query: 89 KNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+ +++ +IYD FR GA S V ++ T+K A+ I K+ + N+I + K+ N++ + +++E+ H+ +I + ++G +LF+ + G YTE R+ Q+L ++YLH+ I+H ++K ENL+ E + I+ I D S + + P PEVL + + A+D W+IGV +ILLCGY PFY E +L+ ++ A+Y ++ + S++ KDF+ HL++ DP+ R AL+HPW
Sbjct: 12 QAEDIRDIYD-----FRDVLGT-GAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIM-ISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: CAMK1G (calcium/calmodulin dependent protein kinase IG [Source:HGNC Symbol;Acc:HGNC:14585]) HSP 1 Score: 144.436 bits (363), Expect = 2.492e-38 Identity = 83/247 (33.60%), Postives = 132/247 (53.44%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN--NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
GA S V R T K FA+ IKK + + N+I + K+ N++ + +++E+ TH ++ + ++G +LF+ + G YTE + +Q+LS ++YLHE I+H ++K ENL+ + E + I+ I D S + I + P PEVL + + A+D W+IGV +ILLCGY PFY E ++L+ + Y + + S + KDF+ HLL+ DP R AL HPW
Sbjct: 32 GAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIM-ITDFGLSKMEQNGIMS-TACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPW 276
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: cmk-1 (Calcium/calmodulin-dependent protein kinase type 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TXJ0]) HSP 1 Score: 131.724 bits (330), Expect = 4.438e-35 Identity = 74/249 (29.72%), Postives = 130/249 (52.21%), Query Frame = 2
Query: 158 GALSVVSACYNRT-TRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
GA S V +++ + +AV I KK + N+I + KL N++++ + ++ + ++ E +TG +LF+ G YTE + +Q+L + ++H+ ++H ++K ENL+ + E + I+ I D S + + P PEVL + A+D+W+IGV +ILLCGY PFY E L+ +I +Y ++ + S++ KDF+ HL+ DP++R +AL HPW
Sbjct: 31 GAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIM-ISDFGLSKTEDSGVM-ATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPW 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: R06A10.4 (pep chromosome:WBcel235:I:1089666:1095796:-1 gene:WBGene00019911.1 transcript:R06A10.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R06A10.4) HSP 1 Score: 122.479 bits (306), Expect = 2.954e-31 Identity = 75/255 (29.41%), Postives = 128/255 (50.20%), Query Frame = 2
Query: 140 CPFQV-----EGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
C ++V +G+ S V +R TRK FAV V+ G NN++ I +L+ ++R+ EVF++ + + ++ + +G ++++ G Y+E + K +L+G+ YLH + H ++K ENL+ DS +L + + P PE+LL T +DMWA+GV +IL+ G PF + + LY +ITA+Y Y S S K F++ LL+ + R++ A+KH W
Sbjct: 69 CKYEVLAVVGKGSFSQVLRVQHRVTRKYFAVKVVNGDCGAV--NNELNILSRLSHPFVIRLEEVFKSSSKLFIVMQMASGGEMYDRVVAKGRYSEEEARNALKMLLTGLTYLHSIRVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKPNETMTETCGTPEYIAPELLLRVPYTQKVDMWAVGVIAYILMSGIMPFDDDCRSRLYTHIITANYVYYPQFWSGSELAKQFVDSLLETNSVERLSSSAAMKHEW 321
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 114.775 bits (286), Expect = 3.546e-29 Identity = 83/299 (27.76%), Postives = 134/299 (44.82%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMD 994
YD+ E+ + GA SVV C ++TT FA +I K D + I KL N++R+ + + + ++ + +TG +LF Y+E+ +QIL I Y H I+H ++K ENL++ +G + K+ D + ++ P PEVL + +D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K ++ +L +PK R+ ALK PW IC + Q V C+ R KV+D
Sbjct: 12 YDVKEELGK------GAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPW--ICNRERVASAIHRQDTVDCLKKFNARRKLKVVD 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 114.775 bits (286), Expect = 3.546e-29 Identity = 83/299 (27.76%), Postives = 134/299 (44.82%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMD 994
YD+ E+ + GA SVV C ++TT FA +I K D + I KL N++R+ + + + ++ + +TG +LF Y+E+ +QIL I Y H I+H ++K ENL++ +G + K+ D + ++ P PEVL + +D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K ++ +L +PK R+ ALK PW IC + Q V C+ R KV+D
Sbjct: 12 YDVKEELGK------GAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPW--ICNRERVASAIHRQDTVDCLKKFNARRKLKVVD 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 114.775 bits (286), Expect = 3.546e-29 Identity = 83/299 (27.76%), Postives = 134/299 (44.82%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMD 994
YD+ E+ + GA SVV C ++TT FA +I K D + I KL N++R+ + + + ++ + +TG +LF Y+E+ +QIL I Y H I+H ++K ENL++ +G + K+ D + ++ P PEVL + +D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K ++ +L +PK R+ ALK PW IC + Q V C+ R KV+D
Sbjct: 12 YDVKEELGK------GAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPW--ICNRERVASAIHRQDTVDCLKKFNARRKLKVVD 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: CaMKI (gene:FBgn0016126 transcript:FBtr0333670) HSP 1 Score: 122.865 bits (307), Expect = 2.074e-31 Identity = 81/284 (28.52%), Postives = 142/284 (50.00%), Query Frame = 2
Query: 53 KKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNR-TTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
KK +K+ K ++EE Y++ H + GA S V ++ + + FAV +I KK + N+I + +L N+++++E +E + + ++ E +TG +LF+ + G YTE + +QIL + Y+HE ++H ++K ENL+ + + I+ I D S + I + P PEVL + A+D+W+IGV +ILLCGY PFY E L+ ++ D+ ++ + S + K F+ +L+ + R AL H W
Sbjct: 11 KKAKAKDLKELNKQVSIEEKYNL-HGLLGT-----GAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIM-ISDFGLSKMEDSGIM-ATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAW 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0333675) HSP 1 Score: 114.39 bits (285), Expect = 8.249e-28 Identity = 78/293 (26.62%), Postives = 134/293 (45.73%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYR-LSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDR 973
YDI E+ + GA S+V C ++T FA +I K D + I KL+ N++R+ + + + ++ + +TG +LF Y+E+ +QIL + + H+ ++H ++K ENL++ +G + K+ D + + D P PEVL + ++D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K+ +N +L +P R+ ALKHPW IC + Q+ V C+ R
Sbjct: 14 YDIKEELGK------GAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW--ICQRERVASVVHRQETVDCLKKFNAR 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0300377) HSP 1 Score: 114.39 bits (285), Expect = 8.254e-28 Identity = 78/293 (26.62%), Postives = 134/293 (45.73%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYR-LSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDR 973
YDI E+ + GA S+V C ++T FA +I K D + I KL+ N++R+ + + + ++ + +TG +LF Y+E+ +QIL + + H+ ++H ++K ENL++ +G + K+ D + + D P PEVL + ++D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K+ +N +L +P R+ ALKHPW IC + Q+ V C+ R
Sbjct: 14 YDIKEELGK------GAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW--ICQRERVASVVHRQETVDCLKKFNAR 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0089217) HSP 1 Score: 114.39 bits (285), Expect = 8.254e-28 Identity = 78/293 (26.62%), Postives = 134/293 (45.73%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYR-LSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDR 973
YDI E+ + GA S+V C ++T FA +I K D + I KL+ N++R+ + + + ++ + +TG +LF Y+E+ +QIL + + H+ ++H ++K ENL++ +G + K+ D + + D P PEVL + ++D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K+ +N +L +P R+ ALKHPW IC + Q+ V C+ R
Sbjct: 14 YDIKEELGK------GAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW--ICQRERVASVVHRQETVDCLKKFNAR 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0089218) HSP 1 Score: 114.39 bits (285), Expect = 8.254e-28 Identity = 78/293 (26.62%), Postives = 134/293 (45.73%), Query Frame = 2
Query: 113 YDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD----NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYR-LSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDR 973
YDI E+ + GA S+V C ++T FA +I K D + I KL+ N++R+ + + + ++ + +TG +LF Y+E+ +QIL + + H+ ++H ++K ENL++ +G + K+ D + + D P PEVL + ++D+WA GV ++ILL GY PF+ E LY + Y Y + ++ + K+ +N +L +P R+ ALKHPW IC + Q+ V C+ R
Sbjct: 14 YDIKEELGK------GAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAV-KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW--ICQRERVASVVHRQETVDCLKKFNAR 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: si:ch73-60h1.1 (si:ch73-60h1.1 [Source:ZFIN;Acc:ZDB-GENE-140106-152]) HSP 1 Score: 182.57 bits (462), Expect = 4.312e-53 Identity = 99/277 (35.74%), Postives = 158/277 (57.04%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YW+ S ++ VE+ Y++G E+ R GA SVV C + T K +AV V+KK + +IG+ L+L+ N++R+ E+FET T I +I E +TG +LF+ + G Y+E + KQIL + YLHE ++H ++K ENL+ D + LKI D S I+ + ++ P C PE+L +DMW++GV ++ILLCG+EPF+ ++ + +Y ++ DY + + E + NA KD +N L+ DP R+ + AL+HPW
Sbjct: 13 YWVDGSRRDATVEDFYNMGPELGR------GATSVVLRCEEKQTEKPYAVKVLKKTIDKKIVRTEIGVLLRLSHPNIIRLKEIFETETEIFLILELVTGGELFDRIVERGYYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSI-DAPLKIADFGLSKIIDEQVTMKTVCGTPGYCAPEILRGNAYGPEVDMWSVGVILYILLCGFEPFFDQRGDQYMYSRILNCDYEFVSPWWDEVSLNA-KDLVNKLIVLDPHKRLTVKQALEHPW 281
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:ZFIN;Acc:ZDB-GENE-050417-76]) HSP 1 Score: 168.318 bits (425), Expect = 1.739e-48 Identity = 90/276 (32.61%), Postives = 154/276 (55.80%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D K + + + Y++ E+ R GA SVV C + T+K +AV ++KK V +IG+ L+L+ N++++ E+FET I+++ E +TG +LF+ + G Y+E KQ+L + YLHE ++H ++K ENL+ S + LKI D S I+ + ++ P C PE+L +DMW++GV +ILLCG+EPF+ ++ + +++ ++ +Y + + ++ S KD + L+ DPK R+ AL+HPW
Sbjct: 15 YWI-DGSKKETLADFYELESELGR------GATSVVYRCRQKGTQKHYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPAEISLVLELVTGGELFDRVVEKGYYSERDAADAVKQVLEAVAYLHENGVVHRDLKPENLLYATSAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGVITYILLCGFEPFFDDRGDQYMFKRILNCEYEFVSPWWDNVSLNAKDLVKKLIVQDPKKRLTTQQALQHPW 282
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:ZFIN;Acc:ZDB-GENE-050417-76]) HSP 1 Score: 168.318 bits (425), Expect = 1.739e-48 Identity = 90/276 (32.61%), Postives = 154/276 (55.80%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D K + + + Y++ E+ R GA SVV C + T+K +AV ++KK V +IG+ L+L+ N++++ E+FET I+++ E +TG +LF+ + G Y+E KQ+L + YLHE ++H ++K ENL+ S + LKI D S I+ + ++ P C PE+L +DMW++GV +ILLCG+EPF+ ++ + +++ ++ +Y + + ++ S KD + L+ DPK R+ AL+HPW
Sbjct: 15 YWI-DGSKKETLADFYELESELGR------GATSVVYRCRQKGTQKHYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPAEISLVLELVTGGELFDRVVEKGYYSERDAADAVKQVLEAVAYLHENGVVHRDLKPENLLYATSAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGVITYILLCGFEPFFDDRGDQYMFKRILNCEYEFVSPWWDNVSLNAKDLVKKLIVQDPKKRLTTQQALQHPW 282
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: pnck (pregnancy up-regulated nonubiquitous CaM kinase [Source:ZFIN;Acc:ZDB-GENE-081105-127]) HSP 1 Score: 157.532 bits (397), Expect = 7.892e-45 Identity = 89/276 (32.25%), Postives = 148/276 (53.62%), Query Frame = 2
Query: 74 IKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
++D K ++ +Y++ ++ EG+ S V +R T+K AV I+K+ ++ N++ + ++N N++ + E FET T + ++ LTG +L N + G YTE R+ Q+L ++YLH+ ++H ++K ENLI E + I+ I D S + + P+ PE+L + +D+WAIGV FILLCGY PFY + T+LY+ +I A+Y ++ S++ KDF+ HLL+ DP R N A +HPW
Sbjct: 4 LRDLRKKDDINAVYELKEKLG------EGSFSEVRVAQHRCTQKLVAVKCIRKRALKGKESMLENEVAVLRRINHENIVSLEETFETPTKLYLVMTLLTGGELLNRILERGSYTEKDASRVIYQVLQAVKYLHQLGVVHRDLKPENLIFETPLEDSKIV-ISDFGLSKMEEQGALS-TACGTPAYVAPELLQQKTYGKEVDLWAIGVITFILLCGYPPFYDDNDTQLYKLIIKAEYEFDSPYWNDISDSAKDFIVHLLQKDPAKRFNCEQASQHPW 271
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: camk1b (calcium/calmodulin-dependent protein kinase Ib [Source:ZFIN;Acc:ZDB-GENE-141014-1]) HSP 1 Score: 156.762 bits (395), Expect = 6.537e-44 Identity = 89/271 (32.84%), Postives = 146/271 (53.87%), Query Frame = 2
Query: 89 KNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
K N+++IYD E+ GA S V + TRK AV I KK +N N+I + K+ N++ + ++FE+ +H+ ++ + ++G +LF+ + G YTE ++ +QIL ++YLH+ I+H ++K ENL+ E + I+ I D S I + P PEVL + + A+D W+IGV +ILLCGY PFY E +L+ ++ A+Y ++ + S++ KDF+ HL++ DP R AL+HPW
Sbjct: 13 KTANIKDIYDF-KEVLGT-----GAFSEVMLAEEKRTRKLVAVKCIAKKALEGKENSIENEIAVLHKIKHANIVSLEDIFESKSHLYLVMQLVSGGELFDRIVEKGFYTEKDASKLIQQILDAVKYLHDMGIVHRDLKPENLLYYSMDEESKIM-ISDFGLSKIEGSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILRAEYEFDSPYWDDISDSAKDFIVHLMEKDPNQRYTCEQALQHPW 276
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: foxf2 (forkhead box F2 [Source:Xenbase;Acc:XB-GENE-484646]) HSP 1 Score: 167.933 bits (424), Expect = 9.715e-49 Identity = 93/276 (33.70%), Postives = 152/276 (55.07%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI S K+ + Y++ E+ R GA SVV C + T++ +AV ++KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + +++ ++ DY + + + S KD + L+ DPK R+ AL+HPW
Sbjct: 10 YWIDGSNKD-TLAHYYELESELGR------GATSVVYRCRQKGTQRPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPWWDDVSLNAKDLVKKLIVFDPKKRLTTQQALQHPW 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: foxf2 (forkhead box F2 [Source:Xenbase;Acc:XB-GENE-484646]) HSP 1 Score: 167.933 bits (424), Expect = 4.897e-48 Identity = 93/276 (33.70%), Postives = 152/276 (55.07%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI S K+ + Y++ E+ R GA SVV C + T++ +AV ++KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + +++ ++ DY + + + S KD + L+ DPK R+ AL+HPW
Sbjct: 22 YWIDGSNKD-TLAHYYELESELGR------GATSVVYRCRQKGTQRPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPWWDDVSLNAKDLVKKLIVFDPKKRLTTQQALQHPW 289
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: foxf2 (forkhead box F2 [Source:Xenbase;Acc:XB-GENE-484646]) HSP 1 Score: 167.548 bits (423), Expect = 5.008e-48 Identity = 93/276 (33.70%), Postives = 152/276 (55.07%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI S K+ + Y++ E+ R GA SVV C + T++ +AV ++KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + +++ ++ DY + + + S KD + L+ DPK R+ AL+HPW
Sbjct: 18 YWIDGSNKD-TLAHYYELESELGR------GATSVVYRCRQKGTQRPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPWWDDVSLNAKDLVKKLIVFDPKKRLTTQQALQHPW 285
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: foxf2 (forkhead box F2 [Source:Xenbase;Acc:XB-GENE-484646]) HSP 1 Score: 167.548 bits (423), Expect = 1.016e-47 Identity = 93/276 (33.70%), Postives = 152/276 (55.07%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI S K+ + Y++ E+ R GA SVV C + T++ +AV ++KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + +++ ++ DY + + + S KD + L+ DPK R+ AL+HPW
Sbjct: 9 YWIDGSNKD-TLAHYYELESELGR------GATSVVYRCRQKGTQRPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPWWDDVSLNAKDLVKKLIVFDPKKRLTTQQALQHPW 276
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: foxf2 (forkhead box F2 [Source:Xenbase;Acc:XB-GENE-484646]) HSP 1 Score: 167.548 bits (423), Expect = 1.016e-47 Identity = 93/276 (33.70%), Postives = 152/276 (55.07%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI S K+ + Y++ E+ R GA SVV C + T++ +AV ++KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + +++ ++ DY + + + S KD + L+ DPK R+ AL+HPW
Sbjct: 9 YWIDGSNKD-TLAHYYELESELGR------GATSVVYRCRQKGTQRPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQYMFKRILNCDYDFVSPWWDDVSLNAKDLVKKLIVFDPKKRLTTQQALQHPW 276
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk4 (calcium/calmodulin-dependent protein kinase IV [Source:MGI Symbol;Acc:MGI:88258]) HSP 1 Score: 170.629 bits (431), Expect = 2.540e-48 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 28 YWI-DGSNRDPLGDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVKKLIVLDPKKRLTTFQALQHPW 295
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk4 (calcium/calmodulin-dependent protein kinase IV [Source:MGI Symbol;Acc:MGI:88258]) HSP 1 Score: 170.629 bits (431), Expect = 2.540e-48 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 28 YWI-DGSNRDPLGDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVKKLIVLDPKKRLTTFQALQHPW 295
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk4 (calcium/calmodulin-dependent protein kinase IV [Source:MGI Symbol;Acc:MGI:88258]) HSP 1 Score: 170.629 bits (431), Expect = 2.540e-48 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 28 YWI-DGSNRDPLGDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVKKLIVLDPKKRLTTFQALQHPW 295
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Pskh1 (protein serine kinase H1 [Source:MGI Symbol;Acc:MGI:3528383]) HSP 1 Score: 151.754 bits (382), Expect = 1.434e-41 Identity = 94/286 (32.87%), Postives = 147/286 (51.40%), Query Frame = 2
Query: 47 RRKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKV--GYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHY--DIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
RR ++ Y K + V YDI I R G+ S V +R TR+ +A+ +I+ K G +++ + ++ N+++++EVFET + ++ E TG +LF+ G +TE R+ + +L G+RYLH I H ++K ENL+ G + I+ I D ++ D + P PEVL+ + T ++DMWA+GV +ILL G PF + T LYR ++ YSY S SN KDF++ LL DP +RM + AL+HPW
Sbjct: 79 RRARVAKYRAK---FDPRVTAKYDIKALIGR------GSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKII-ITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYLGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPW 354
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk1 (calcium/calmodulin-dependent protein kinase I [Source:MGI Symbol;Acc:MGI:1098535]) HSP 1 Score: 147.132 bits (370), Expect = 2.899e-40 Identity = 84/271 (31.00%), Postives = 145/271 (53.51%), Query Frame = 2
Query: 89 KNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+ +++ +IYD FR GA S V ++ T+K A+ I KK + N+I + K+ N++ + +++E+ H+ +I + ++G +LF+ + G YTE R+ Q+L ++YLH+ I+H ++K ENL+ E + I+ I D S + + P PEVL + + A+D W+IGV +ILLCGY PFY E +L+ ++ A+Y ++ + S++ KDF+ HL++ DP+ R AL+HPW
Sbjct: 12 QAEDIRDIYD-----FRDVLGT-GAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIM-ISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P13234|KCC4_RAT (Calcium/calmodulin-dependent protein kinase type IV OS=Rattus norvegicus OX=10116 GN=Camk4 PE=1 SV=3) HSP 1 Score: 172.94 bits (437), Expect = 2.701e-48 Identity = 94/277 (33.94%), Postives = 155/277 (55.96%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D K + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 28 YWI-DGSKRDPLSDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVKKLIVLDPKKRLTTFQALQHPW 295
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q16566|KCC4_HUMAN (Calcium/calmodulin-dependent protein kinase type IV OS=Homo sapiens OX=9606 GN=CAMK4 PE=1 SV=1) HSP 1 Score: 170.629 bits (431), Expect = 1.622e-47 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 32 YWI-DGSNRDALSDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVRKLIVLDPKKRLTTFQALQHPW 299
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P08414|KCC4_MOUSE (Calcium/calmodulin-dependent protein kinase type IV OS=Mus musculus OX=10090 GN=Camk4 PE=1 SV=2) HSP 1 Score: 169.474 bits (428), Expect = 4.875e-47 Identity = 93/277 (33.57%), Postives = 154/277 (55.60%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YWI D + + +++ E+ R GA S+V C + T+K +A+ V+KK V +IG+ L+L+ N++++ E+FET T I+++ E +TG +LF+ + G Y+E KQIL + YLHE I+H ++K ENL+ + LKI D S I+ + + ++ P C PE+L +DMW++G+ +ILLCG+EPFY E+ + ++R ++ +Y + + E + NA KD + L+ DPK R+ AL+HPW
Sbjct: 28 YWI-DGSNRDPLGDFFEVESELGR------GATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP-DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNA-KDLVKKLIVLDPKKRLTTFQALQHPW 295
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P25323|MYLKA_DICDI (Myosin light chain kinase A OS=Dictyostelium discoideum OX=44689 GN=mlkA PE=1 SV=2) HSP 1 Score: 158.303 bits (399), Expect = 1.688e-44 Identity = 91/268 (33.96%), Postives = 149/268 (55.60%), Query Frame = 2
Query: 101 VEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVI-KKKVGYCPDNN---DIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
VE+IY+ E+ R GA S+V N+ T++ +A+ VI K ++G + N ++ I K+N N++ + E+F+T + ++ E +TG +LF+ + G Y+E+ + K+I+S + YLH NI+H ++K ENL++ S E +L + I D S I+ + + PS PEVL + +DMW+IGV +ILLCG+ PFY + + E++ ++ A+Y + S KDF+ LL D R+N NAL HPW
Sbjct: 4 VEKIYEFKEELGR------GAFSIVYLGENKQTKQRYAIKVINKSELGKDYEKNLKMEVDILKKVNHPNIIALKELFDTPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHGLNIVHRDLKPENLLL-KSKENHLEVAIADFGLSKIIGQTLVMQTACGTPSYVAPEVLNATGYDKEVDMWSIGVITYILLCGFPPFYGDTVPEIFEQIMEANYEFPEEYWGGISKEAKDFIGKLLVVDVSKRLNATNALNHPW 264
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0V7M1|KPSH1_BOVIN (Serine/threonine-protein kinase H1 OS=Bos taurus OX=9913 GN=PSKH1 PE=2 SV=1) HSP 1 Score: 152.91 bits (385), Expect = 3.751e-41 Identity = 94/286 (32.87%), Postives = 148/286 (51.75%), Query Frame = 2
Query: 47 RRKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKV--GYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHY--DIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNC-ESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
RR ++ Y K + V YDI I R G+ S V +R TR+ +A+ +I+ K G +++ + ++ N+++++EVFET + ++ E TG +LF+ G +TE R+ + +L G+RYLH I H ++K ENL+ G + I+ I D ++ D + P PEVL+ + T ++DMWA+GV +ILL G PF + T LYR ++ YSY+ S SN KDF++ LL DP +RM + AL+HPW
Sbjct: 79 RRARVAKYRAK---FDPRVTAKYDIKALIGR------GSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKII-ITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPW 354
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267GGV5 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011758g1 PE=3 SV=1) HSP 1 Score: 204.142 bits (518), Expect = 4.128e-59 Identity = 102/275 (37.09%), Postives = 164/275 (59.64%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YW+K+SIK+ E +Y++G E+ R GA S+V C + + +AV +I+KKV + +IG+ L ++ N++R+ E+FET +HI ++ EH+TG +LF+ G Y+E +Q+L ++YLHE +IIH ++K ENL + +S + LK+ D S I+ D+ L++ P C PEVLLS+ +DMW++GV +ILLCGYEPFY E +++YR ++ Y ++ + S KD ++ L+ DP R+ AL+HPW
Sbjct: 5 YWVKESIKDTPFESVYELGSELGR------GATSIVYECRLIGSNQKWAVKIIQKKVDKKIVSTEIGVLLSVSHPNIIRLKELFETASHIYMVLEHVTGGELFDRIVSRGSYSEKDAAICVQQLLQALKYLHEKDIIHRDLKPENL-LYESESDDACLKVADFGLSKIVSDDVQTLTVCGTPGYCAPEVLLSRDYGTPVDMWSVGVITYILLCGYEPFYAENESDMYRRILRGQYEFDSPWWDEISRNAKDLVSRLMLLDPAKRLTASQALRHPW 272
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1S3I026 (calcium/calmodulin-dependent protein kinase type IV OS=Lingula unguis OX=7574 GN=LOC106159758 PE=3 SV=1) HSP 1 Score: 196.438 bits (498), Expect = 3.042e-56 Identity = 103/280 (36.79%), Postives = 160/280 (57.14%), Query Frame = 2
Query: 53 KKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+KM YWI+DSIK++ E+ Y+I E+ + GA SVV C + + +AV ++ KKV + G+ LKL N++R+ E++ET T I ++ E +TG +LF+ G Y+E KQ+L +++LH+ ++ H ++K ENL+ DS + +L LK+ D S I +I ++ P C PEVL + A+DMW++GV +ILLCGYEPFY + E+Y+ +I DY ++ + S KD + LLK DP R+ AL+HPW
Sbjct: 4 EKMQDYWIEDSIKDKKFEDYYNIVKELGK------GATSVVYRCEQKGLAQPWAVKILTKKVDKKIVRTECGVLLKLKHSNVIRLKEIYETPTQIYLVLELVTGGELFDRIVTRGCYSEKDAANCVKQMLDAVKFLHQNDVAHRDLKPENLLYQDSSDESL-LKVADFGLSKICESNIQMSTVCGTPGYCAPEVLQGNPYSTAVDMWSVGVITYILLCGYEPFYCDNEKEMYKKIIKGDYMFDAPWWDDVSENAKDLVRQLLKVDPAERLTSSQALEHPW 276
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267GU18 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig020174g1 PE=3 SV=1) HSP 1 Score: 194.897 bits (494), Expect = 1.762e-55 Identity = 105/275 (38.18%), Postives = 156/275 (56.73%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCEST-SNALKDFLNHLLKADPKSRMNIINALKHPW 889
YW+ +SIK+ E++YD+G E+ + G SVV C + + +A VI+KKV +IGI L ++ N++R+ EVFET H ++ E +TG +LF+ G Y E + +Q+L G+RYLHE IIH ++K ENL+ D E LKI D S I D++ S+ P C PEVLL + A+DMW++GV FILL GYEPFY + +++YR ++ A Y+++ S S +D + LL D +R+ AL+HPW
Sbjct: 5 YWLYESIKDIRFEDVYDLGKELGK------GGTSVVHECNRIGSSEKWAAKVIQKKVDKRIVTAEIGILLSVSHENIIRLKEVFETPNHFFMVLELVTGGELFDRIVSRGSYNEKDASQCIRQLLDGLRYLHERGIIHRDLKPENLLYEDERE-EAKLKIADFGLSKIADSDVHTRSVCGTPGYCAPEVLLRRGCGTAMDMWSVGVIAFILLGGYEPFYADNDSDMYRRILRAQYTFDQRWWSGISKNARDLIERLLVLDADARLTAGQALRHPW 272
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A4D6Q5Z3 (Calcium/calmodulin-dependent protein kinase type IV-like OS=Onchidium struma nom. nud. OX=643549 GN=MKIV PE=2 SV=1) HSP 1 Score: 192.586 bits (488), Expect = 1.413e-54 Identity = 103/278 (37.05%), Postives = 158/278 (56.83%), Query Frame = 2
Query: 59 MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
M YWI +SIK+ E++YD+G E+ R GA SVV C + T +++AV ++ K+V +IGI LKLN N++R+ EVFET H ++ E +TG +LF Y+E + + I++G+ YLH ++++H ++K EN I+ +S N LKI D STI+ + ++ P C PEVL + + DMW++GV +ILLCGYEPFY E +++ ++ DY ++ + S+ KD + LL DPK R+ ALKH W
Sbjct: 5 MQEYWIAESIKDTKFEDVYDLGKELGR------GATSVVHKCCVKGTDQAWAVKIMDKRVELKTIVTEIGILLKLNHPNIVRMKEVFETLDHDYIVLELVTGSELFERIITQEYYSEEQAATAIRDIITGVEYLHNHDVVHRDLKPEN-ILYESLSLNSKLKIADFGLSTIVSGKVALTTVCGTPGYCAPEVLKGEKYFKSCDMWSVGVIAYILLCGYEPFYAENEATMFKKILKGDYKFDSPWWDDVSDNAKDLVRKLLVVDPKKRLTPAAALKHVW 275
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1I8GVX7 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 188.348 bits (477), Expect = 2.076e-53 Identity = 102/289 (35.29%), Postives = 162/289 (56.06%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESI 931
+W+K+SIK+ + +YD+ E+ R GA SVV AC R T + +AV VI+KKV +IGI L ++ N++R+ E+FET THI+ + E++TG +LF+ G Y+E + +Q+L ++YLHE +IIH ++K ENL + ++ + LKI D S I+ D+ ++ P C PEVLL + L LCGYEPFY E +E+YR ++ A Y ++ + S +D ++ L++ DP R+ AL+HPW K +PL+++
Sbjct: 5 FWLKESIKDVPFDSVYDLCSELGR------GATSVVFACQKRGTNEKWAVKVIQKKVDKKIVATEIGILLTISHPNIIRLKELFETSTHIHTVLEYVTGGELFDRIVSRGNYSEQDAAQCVRQLLEALKYLHEKDIIHRDLKPENL-LYENERDDACLKIADFGLSKIISQDVQTATVCGTPGYCAPEVLLGKGYGTPL----FSPTASPRLCGYEPFYAENDSEMYRKILRAQYEFDSPWWDGISRNARDLVSGLMQLDPAKRLTAAQALQHPWVSGQAAKTEPLQAV 282
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: si:ch73-60h1.1 (calcium/calmodulin-dependent protein kinase type IV-like [Source:NCBI gene;Acc:103036728]) HSP 1 Score: 179.874 bits (455), Expect = 5.966e-52 Identity = 97/277 (35.02%), Postives = 159/277 (57.40%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
YW++ S ++ ++EE Y +G E+ R GA SVV C + T K +A V+KK + +IG+ L+L+ N++R+ E+FET T I++I E +TG +LF+ + G Y+E + KQIL + YLHE ++H ++K ENL+ D + LKI D S I+ + ++ P C PE+L +DMW++GV ++ILLCG+EPF+ + + +Y ++ DY + + E + NA KD ++ L+ DP R+++ AL+HPW
Sbjct: 13 YWVEGSRRDASMEEFYTMGPELGR------GATSVVFRCEEKQTEKPYAAKVLKKTIDKKIVRTEIGVLLRLSHPNIIRLKEIFETETEISLILELVTGGELFDRIVERGYYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSI-DAPLKIADFGLSKIIDEQVTMKTVCGTPGYCAPEILRGNAYGPEVDMWSVGVILYILLCGFEPFFDPRGDQYMYSRILNCDYEFVSPWWDEVSLNA-KDLVSKLIVLDPHKRLSVQQALEHPW 281
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: camk4 (calcium/calmodulin dependent protein kinase IV [Source:NCBI gene;Acc:103044753]) HSP 1 Score: 171.014 bits (432), Expect = 1.756e-49 Identity = 93/284 (32.75%), Postives = 159/284 (55.99%), Query Frame = 2
Query: 44 SRRKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
SR YWI DS K + + + Y++ E+ R GA SVV C + T+K +AV ++KK V +IG+ L+L+ N++++ E+FET I+++ E +TG +LF+ + G Y+E KQ+L + YLHE+ ++H ++K ENL+ S + LKI D S I+ + ++ P C PE+L +DMW++GV +ILLCG+EPF+ ++ + +++ ++ +Y + + ++ S KD + L+ DPK R+ + AL+HPW
Sbjct: 9 SRPGAAPEYWIDDS-KRETLADFYELECELGR------GATSVVFRCRQKGTQKPYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPLEISLVLELVTGGELFDRVVEKGYYSERDAADAIKQVLEAVAYLHEHGVVHRDLKPENLLYATSAP-DAPLKIADFGLSKIIDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGVITYILLCGFEPFFDDRGDQYMFKRILNCEYEFVSPWWDNVSLNAKDLVKKLIVQDPKKRLTTLQALQHPW 284
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: si:ch73-60h1.1 (calcium/calmodulin-dependent protein kinase type IV-like [Source:NCBI gene;Acc:103036728]) HSP 1 Score: 163.696 bits (413), Expect = 9.673e-46 Identity = 89/251 (35.46%), Postives = 143/251 (56.97%), Query Frame = 2
Query: 146 FQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
F GA SVV C + T K +A V+KK + +IG+ L+L+ N++R+ E+FET T I++I E +TG +LF+ + G Y+E + KQIL + YLHE ++H ++K ENL+ D + LKI D S I+ + ++ P C PE+L +DMW++GV ++ILLCG+EPF+ + + +Y ++ DY + + E + NA KD ++ L+ DP R+++ AL+HPW
Sbjct: 37 FFSRGATSVVFRCEEKQTEKPYAAKVLKKTIDKKIVRTEIGVLLRLSHPNIIRLKEIFETETEISLILELVTGGELFDRIVERGYYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSI-DAPLKIADFGLSKIIDEQVTMKTVCGTPGYCAPEILRGNAYGPEVDMWSVGVILYILLCGFEPFFDPRGDQYMYSRILNCDYEFVSPWWDEVSLNA-KDLVSKLIVLDPHKRLSVQQALEHPW 285
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: pnck (calcium/calmodulin-dependent protein kinase type 1B-like [Source:NCBI gene;Acc:103046554]) HSP 1 Score: 154.066 bits (388), Expect = 2.014e-43 Identity = 84/249 (33.73%), Postives = 137/249 (55.02%), Query Frame = 2
Query: 155 EGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
EG+ S V +R T K AV I+K+ ++ N+I + ++ N++ + E FET T + ++ +TG +L + + G YTE R+ Q+L ++YLH+ I+H ++K ENL+ E + I+ I D S + + P+ PE+L + +D+WA+GV FILLCGY PFY E T+LY+ +I A++ ++ + S++ KDF+ HLL+ DP+ R N AL+HPW
Sbjct: 26 EGSFSEVRVAQHRKTHKLVAVKCIRKRALKGKESMLENEIAVLRRIKHENIISLEETFETPTKLYLVMTLVTGGELLDRILERGSYTEKDASRVILQVLEAVKYLHQLGIVHRDLKPENLLYETPLEDSKIV-ISDFGLSKMEEQGALS-TACGTPAYVAPELLQQKTYGKGVDLWALGVISFILLCGYPPFYDENDTQLYKQIIKAEFEFDSPYWDDISDSAKDFIVHLLQKDPERRFNCEQALQHPW 272
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: pnck (calcium/calmodulin-dependent protein kinase type 1B-like [Source:NCBI gene;Acc:103046554]) HSP 1 Score: 154.066 bits (388), Expect = 2.014e-43 Identity = 84/249 (33.73%), Postives = 137/249 (55.02%), Query Frame = 2
Query: 155 EGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
EG+ S V +R T K AV I+K+ ++ N+I + ++ N++ + E FET T + ++ +TG +L + + G YTE R+ Q+L ++YLH+ I+H ++K ENL+ E + I+ I D S + + P+ PE+L + +D+WA+GV FILLCGY PFY E T+LY+ +I A++ ++ + S++ KDF+ HLL+ DP+ R N AL+HPW
Sbjct: 26 EGSFSEVRVAQHRKTHKLVAVKCIRKRALKGKESMLENEIAVLRRIKHENIISLEETFETPTKLYLVMTLVTGGELLDRILERGSYTEKDASRVILQVLEAVKYLHQLGIVHRDLKPENLLYETPLEDSKIV-ISDFGLSKMEEQGALS-TACGTPAYVAPELLQQKTYGKGVDLWALGVISFILLCGYPPFYDENDTQLYKQIIKAEFEFDSPYWDDISDSAKDFIVHLLQKDPERRFNCEQALQHPW 272
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003135.1 (pep scaffold:Pmarinus_7.0:GL491838:799:5626:1 gene:ENSPMAG00000002863.1 transcript:ENSPMAT00000003135.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 125.946 bits (315), Expect = 3.008e-34 Identity = 76/255 (29.80%), Postives = 130/255 (50.98%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREH----LTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCP---PEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
GA S V R+T + A+ I K DN N++ + ++ N++ + +++ET +H+ +I + + G +LF+ + G YTE + +Q+L + +LH ++H ++K ENL+ S E + + I D S + + P PEVL + T A+D W+IGV +ILLCGY PFY E + L+ ++ A+Y ++ + S++ KDF+ HL++ D R AL+HPW
Sbjct: 2 GAFSEVVLAEERSTGRHVAIKCIAKTALRGKDNTVENEVCVLSRIKHENIIALEDIYETDSHLYLIMQLVLLLIRGGELFDRIVERGFYTERDASALIRQVLRAVSHLHGQGVVHRDLKPENLLYY-SAEDDSKIMISDFGLSKVEAPGSVMSTACGTPGYVACEAPEVLAQKPYTRAVDCWSIGVISYILLCGYPPFYDEVDSRLFDQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDVAERFTCEQALQHPW 255
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001278.1 (pep scaffold:Pmarinus_7.0:GL476529:253165:339525:-1 gene:ENSPMAG00000001147.1 transcript:ENSPMAT00000001278.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 114.005 bits (284), Expect = 1.478e-29 Identity = 74/255 (29.02%), Postives = 126/255 (49.41%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKV------GYCPDN--NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDH-IQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNAL-KDFLNHLLKADP-KSRMNIINALKHPW 889
G +VV C + + FA IKK+ G P++ ++ I +L N++ + EV+E T + +I E ++G +LF+ +E + KQIL G+ YLH I H ++K EN++++++ +KI D + +I+ +R I P PE++ + DMW+IGV +ILL G PF + E + +Y ++ ++AL K+F+ LL P + RMN+ A+ HPW
Sbjct: 4 GQFAVVKKCCEKKSGLEFAAKFIKKRRSRSSRRGVVPEDIKREVSILRELRHPNIISLHEVYENDTDVTLILELVSGGELFDFLAHKESLSEDEATEFLKQILDGVSYLHCRRIAHFDLKPENIMLLENRAPKAHVKIIDFGLAQSIVDGVEFR-HIFGTPEFVVPEIVNYEPLGVQADMWSIGVMTYILLSGASPFLGDTKEETLSNISAVEYKFDEEYFKQTSALAKNFIQRLLLKSPNRERMNVEEAIHHPW 257
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: dapk1 (death-associated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-060526-177]) HSP 1 Score: 116.316 bits (290), Expect = 1.255e-28 Identity = 72/254 (28.35%), Postives = 122/254 (48.03%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKV-------GYCPDN--NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
G +VV C +T+ + FA +I+K G ++ ++ + L N++ + +VFE+ + +I E ++G +LF+ K +E + KQIL G+ YLH +I H ++K ++++ + N +K+ D + I+ I +I P PEV+ + DMW+IGV +ILL G PF + E + Y ++ + TS DF+ LL DPK RM + + L HPW
Sbjct: 2 GHFAVVKRCREKTSGEEFAAKLIRKSRSARSSRRGVVREDIEREVNVLRGLRHPNVIALHDVFESKADVILILELVSGGELFDFLAKKDALSEEEATEFIKQILDGVHYLHSKHIAHFDLKKPFFMLLECNQPNPRIKLIDFGLAHIIEEGIEFRNIFGTPEFVAPEVVNYEPLGLEADMWSIGVITYILLSGASPFLGDSKQETLTNITGVKYEFDEEYFDQTSQLAMDFIRRLLVKDPKKRMTVKDCLSHPW 255
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008748.1 (pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 gene:ENSPMAG00000007907.1 transcript:ENSPMAT00000008748.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 110.153 bits (274), Expect = 1.324e-27 Identity = 76/279 (27.24%), Postives = 127/279 (45.52%), Query Frame = 2
Query: 155 EGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIG----IFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYR-LSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDR 973
+GA SVV C +T + FA +I K D+ + I L N++R+ E ++ + +TG +LF Y+E+ +QIL + + H++ I+H ++K ENL++ +G + K+ D + + D P PEVL +DMWA GV ++ILL GY PF+ E +LY+ + Y + + ++ + K+ +N +L +P R+ ALKHPW IC Q+ V+C+ R
Sbjct: 22 KGAFSVVRRCVKVSTGQEFAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHESIAEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHQHGIVHRDLKPENLLLASKMKGAAV-KLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTAEAKNLINQMLTINPAKRITAAEALKHPW--ICQRSTVASCMHRQETVECLRKFNAR 297
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010548.1 (pep scaffold:Pmarinus_7.0:GL477749:266235:284843:-1 gene:ENSPMAG00000009555.1 transcript:ENSPMAT00000010548.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 106.686 bits (265), Expect = 1.356e-25 Identity = 73/277 (26.35%), Postives = 125/277 (45.13%), Query Frame = 2
Query: 95 QNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSF--AVNVIKKKVGYCPDN---NDIGIFLKLND-VNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPF--YREKITELYRAVITADYS----YNFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
Q++E Y+IG I F VS+ + A+ +I K + +++ + +L N++R++E E+ + ++ E + G LF+ +S +TE + + ++YLH NI+H ++K ENL++ + +G LK+ D + + IY ++ P+ PE+L +DMWA GV +ILLCG+ PF EL+ + +Y Y + A KD ++ LL D R AL HPW
Sbjct: 357 QDIESRYEIGRTIGDGNFATVKECRRVSSGDGSAGEAEWDLAMKIIDKAKLVGREEMLRSEVALTTRLGQHPNVVRLVEAMESPSDAYLVLERVRGGDLFDAITESVRFTERHAAAMVADLCRALQYLHANNIVHRDVKPENLLVQRNADGGTTLKLADLGLAMEVTGPIY--TVCGTPTYVAPEILAETGYGLEVDMWAAGVITYILLCGFPPFRSLERDQEELFEIIQLGEYEFLSPYWDHISDGHEAAKDLVSRLLVVDTARRYTARQALHHPW 631
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910]) HSP 1 Score: 111.309 bits (277), Expect = 1.015e-27 Identity = 78/259 (30.12%), Postives = 122/259 (47.10%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNV-IKK-----KVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVD-SGEGNLILK---ICDHIQS--TIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN---CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
G VV N T + AV + IKK KV +++ I +L+ N++ + FE+ +I + G +LF+ K G +TE RI +ILS ++Y+H NI+H ++K ENL+ +D S E L++ I ++S +++ L +A PEVL D+W+IGV + LLCGY F E++ + T +Y F+ +S SN K F+ L DP R L+ PW
Sbjct: 46 GTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVA------PEVLTQDGHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLEDPW 298
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: RAD53 (DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]) HSP 1 Score: 105.531 bits (262), Expect = 2.961e-25 Identity = 67/271 (24.72%), Postives = 127/271 (46.86%), Query Frame = 2
Query: 155 EGALSVVSACYNRTTRKSFAVNVIKKK--VGYCPD-NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFA-------------LDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYN-FNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQ 916
+GA + V RTT K+FAV +I K+ +G ++ + KLN ++R+ +E ++ E ++G L + G E I++QIL+ I+Y+H I H ++K +N++I + +++KI D + + + + + PEV+ + + + +DMW++G V+++L G+ PF +LY+ + Y S +DF++ LL+ DP +R AL HPW ++ + +Q
Sbjct: 206 QGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILI--EQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ 474
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK2 (Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005376]) HSP 1 Score: 98.5969 bits (244), Expect = 2.731e-23 Identity = 73/260 (28.08%), Postives = 116/260 (44.62%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNN--------DIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYD---IYRLSIIALPSL--CPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNC---ESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
G+ VV +T + A+ ++ KK NN ++ I KL+ N++ + FE+ ++ + TG +LF+ G +TE I QIL + Y+H N++H ++K EN++ VD E N L I D + + + IY+ A SL PEVL D+W+IGV + LLCGY PF E + + Y F+ ++ S +K F+ L+ +P R L PW
Sbjct: 56 GSFGVVRQARKLSTNEDVAIKILLKKA--LQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSE-NSPLVIADFGIAKQLKGEEDLIYK----AAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPW 308
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130]) HSP 1 Score: 94.7449 bits (234), Expect = 2.495e-22 Identity = 65/221 (29.41%), Postives = 104/221 (47.06%), Query Frame = 2
Query: 260 DIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPL 922
++ I LN NL + F + ++ E+L +++ + GP+ + QI + + Y+H+ NIIH +IK EN++I G N+I K+ D S I + R ++ PE++ S+ +D WA+GV F LL G PF E Y+ + D N S +D + LLK DPK RM + + HPW I++N+P
Sbjct: 152 EVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILI---GFNNVI-KLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNI---SQDAQDLILKLLKYDPKDRMRLGDVKMHPW----ILRNKPF 361
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: DUN1 (Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role [Source:SGD;Acc:S000002259]) HSP 1 Score: 92.8189 bits (229), Expect = 3.553e-21 Identity = 65/271 (23.99%), Postives = 126/271 (46.49%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNN-----DIGIFLKLNDVNLMRVIEVF-----ETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIV---------------DSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYRE-KITELYRAVITADYS-YNFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
G ++V N+ T + AV + + N + I +++ N++ +++ F ++ ++ E + +LF + + + + KQ+L+G++YLHE NIIH +IK EN+++ D E ++ +KI D + + ++ PS PEVL + T +D+W+ GV +++ LCG+ PF + L ++ A Y+ Y+ + +++ +++LL +P R NI AL HPW
Sbjct: 209 GHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPW 479
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO42276 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1X1]) HSP 1 Score: 179.874 bits (455), Expect = 6.570e-54 Identity = 95/275 (34.55%), Postives = 151/275 (54.91%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
Y+ +D + + +E+ YDIG E+ R GA SVV C + T K FAV ++KK V + GI ++N N++ + E+FET TH+ ++ E +TG +LF+ + G Y E K IL + +LH+ +I+H ++K ENL+ + E + LKI D S I+ ++ ++ P C PEVL + +DMWAIGV +ILLCG+EPFY E ++++ ++ DY + + + S+ KD + L+ D R+ AL HPW
Sbjct: 3 YFFEDLSRKEPIEDFYDIGKELGR------GASSVVKLCRQKGTNKEFAVKIMKKTVDKKIIQTETGILFRINHPNIIHMKELFETHTHLFMVLELVTGGELFDRVVEKGYYCEKDAADAIKMILEAVGHLHKNDIVHRDLKPENLLYANERE-DSPLKIADFGLSKILPQEVMTSTVCGTPGYCAPEVLKGESYDTGVDMWAIGVIAYILLCGFEPFYDETDQQMFQRILKCDYDFVSPWWDDVSSGAKDLVKRLITGDKNKRLTAKQALDHPW 270
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36253 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ85]) HSP 1 Score: 142.895 bits (359), Expect = 7.295e-40 Identity = 82/248 (33.06%), Postives = 126/248 (50.81%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
GA S V + T FAV I KK + N+I I K+ N++ + ++F+ +H+ ++ + + G +LF+ + G YTE + +QIL YLH I+H ++K ENL+ E + I+ I D S I + + P PEVL Q A+D W+IGV +ILLCGY PFY + L+ ++ A+Y ++ + S + KDF+ HL++ DPK R AL HPW
Sbjct: 26 GAFSEVVLAEEKATGSLFAVKCISKKELKGKEESVENEIAILKKVRHKNIIGLKDIFDNKSHLYLVMDLVQGGELFDRIVEKGNYTEQDASALVQQILEAADYLHSLGIVHRDLKPENLLYYSPDEDSKIM-ISDFGLSKIEAQGSFMDTACGTPGYVAPEVLKQQPYGKAVDCWSIGVITYILLCGYPPFYDDSDANLFAQIMRAEYEFDSPYWDEISESAKDFIRHLMELDPKLRYTCRQALSHPW 272
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO44488 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVP7]) HSP 1 Score: 121.324 bits (303), Expect = 2.737e-32 Identity = 71/249 (28.51%), Postives = 123/249 (49.40%), Query Frame = 2
Query: 155 EGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+G +VV C +R T K +A+ +I K ++ N+I I ++ +++ +IE +ET I ++ E + G LF ++ YTE + + + S + YLH +I+H +IK ENL++++ G LK+ D M + P+ PE+L +D+WA GV +ILLCG+ PF EL+ ++ ++ Y + S++ KD ++H+L D R + L HPW
Sbjct: 9 DGNFAVVRECKHRKTNKEYALKIINKAKVKGKEHMIENEISILRRVKHNHIVELIEEYETPREIFLVMELVKGGDLFEAIVEATKYTEVHASHMVRDLASALDYLHCNSIVHRDIKPENLLVLNLPNGRKSLKLADF--GLAMEVKSPMFLVCGTPTYVAPEILDESGYGLKVDIWAAGVISYILLCGFPPFRSPDQDELFDLILAGEFEYLSPFWNDISSSAKDLIDHMLVVDANQRYSAKQVLAHPW 255
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO35611 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SL08]) HSP 1 Score: 120.553 bits (301), Expect = 5.814e-31 Identity = 82/293 (27.99%), Postives = 145/293 (49.49%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHY--DIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNC-ESTSNALKDFLNHLLKADPKSRMNIINALKHPW----NEICIMKNQPLESIYQQYVKCVG-SIEDRMHEKVMDDIRRAN 1012
G+ S V + T++ +A+ +++ + G +++ + ++ ++R+ EVFE + ++ E TG L + G +TE R+ +L G+RYLH I H ++K ENL+ G + I+ I D S + + D + P PEVLLS+ T ++D+W+IGV F +L G PF + + LY+ ++ +S++ + ++ KDF+N L+ +P+ R+ +KHPW +KN +SI Q +K G S + +K IR AN
Sbjct: 79 GSFSRVVRVEHYQTKQPYAIKMMEIEQGKDEFQSELAVLRRVKHEFVVRLYEVFECRNRVYLVMELATGGVLLDRILSKGFFTERDATRVIYMVLEGVRYLHSLGITHRDLKPENLLYYHPGNDSKIM-ITDFGLSNLRKHPDDRTMETTCGTPGYMAPEVLLSKPYTNSVDIWSIGVITFNVLSGQMPFADDHRSRLYKKILRGKFSFSGEPWDDVTDMAKDFINKLIVYEPEMRLTAEQGIKHPWIASSAATSSLKNLH-KSISQNLLKSRGNSAKSNRSQKSNRSIRIAN 369
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33022 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STC5]) HSP 1 Score: 116.316 bits (290), Expect = 5.000e-30 Identity = 80/274 (29.20%), Postives = 134/274 (48.91%), Query Frame = 2
Query: 104 EEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVI--------KKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDI---YRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSY-NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
E++Y+I F +GA VS C N TR+ FAV I KKK N+ I L+ +++ + +VF T + ++ E+L G LF+ ++E +Q+L +RYL IIH ++K ENL++ + + DH I D +L P PE +L + T+A+D+WA GV +++LL GY PF+ E+ L +++ ++Y++ + ++ S KD + +L DP+ R+ + ALKH W
Sbjct: 4 EDVYEITD------FIGKGAFGQVSKCVNLQTREVFAVKEIDFSGSEEDKKKA-----QNEAKICGLLDHPSIVHLEDVFFTPRRMLLVLEYLPGGDLFDGVVTRTQFSEKDACACVRQVLKALRYLTRKGIIHRDLKPENLLLSE--------RPSDHRPPIIKLTDFGIAKQLKGNGSPLYLAPETILEEGLTYAVDIWACGVILYLLLVGYPPFWNEQTEFLLLSILQSNYTFPSPYWDTVSEPAKDLIRKMLVVDPRDRITAVEALKHEW 258
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: si:ch73-60h1.1 (calcium/calmodulin-dependent protein kinase type IV [Source:NCBI gene;Acc:101155594]) HSP 1 Score: 175.252 bits (443), Expect = 7.340e-50 Identity = 94/277 (33.94%), Postives = 157/277 (56.68%), Query Frame = 2
Query: 68 YWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITE-LYRAVITADYSY--NFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+W+ S ++ VE+ Y +G E+ R GA S+V C + T+K +AV V+KK + +IG+ L+L+ N++++ E+FET T I ++ E +TG +LF+ + G Y+E + KQIL + YLHE ++H ++K ENL+ D + LKI D S I+ + ++ P C PE+L +DMW++GV ++ILLCG+EPF+ + + +Y ++ DY + + E + NA KD + L+ DP R+++ AL+HPW
Sbjct: 13 FWVDGSRRDGTVEDFYTLGSELGR------GATSIVYRCEEKQTQKPYAVKVLKKTIDKKIVRTEIGVLLRLSHPNIIQLKEIFETDTDIALVLELVTGGELFDRIVERGYYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSL-DASLKIADFGLSKIIDDQVTMKTVCGTPGYCAPEILRGNAYGPEVDMWSVGVILYILLCGFEPFFDPRGDQYMYSRILNCDYEFVSPWWDEVSLNA-KDLVGKLIVLDPHKRLSVREALQHPW 281
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000012877.2 (calcium/calmodulin-dependent protein kinase type 1D [Source:NCBI gene;Acc:101157124]) HSP 1 Score: 147.902 bits (372), Expect = 1.869e-40 Identity = 81/282 (28.72%), Postives = 153/282 (54.26%), Query Frame = 2
Query: 50 RKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKK-VGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
RK++ C W K + N+++++D ++ G+ S V + T + +A+ +KKK + + N+I I ++ N++ + + +E+ TH ++ + ++G +LF+ G YTE R+ KQ+L + YLH+ +I+H ++K ENL+ ++ E I+ + D S + + + P PEVL + + A+D W+IGV +ILLCGY PF+ E T L+ ++ A+Y+++ + S + KDF+ ++++ +P R AL+HPW
Sbjct: 3 RKEITCSWKKST---SNIKDVFDFEGKMG------SGSFSEVFMVREKKTGRLYALKCLKKKHLAHSNLENEINILRRIKHENVVGLEDFYESRTHYYLVMQLVSGGELFDRILDKGVYTEKDASRVIKQVLQAVSYLHQNSIVHRDLKPENLLFFNTDENAKIM-VSDFGLSKTPEHGVMS-TACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFFEENETRLFSKIMRAEYAFHSPFWDDISESAKDFVRNMMEKNPLKRFTTEQALRHPW 273
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk1gb (calcium/calmodulin-dependent protein kinase type 1D [Source:NCBI gene;Acc:101164726]) HSP 1 Score: 146.747 bits (369), Expect = 7.618e-40 Identity = 88/282 (31.21%), Postives = 151/282 (53.55%), Query Frame = 2
Query: 50 RKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPD-NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
R++ D W K + +N++EI+D+ E+ GA S V R T K FA+ IKKK + N++ + ++ N++ + +++E+ TH +I + ++G +LF+ G YTE R+ +Q+L + YLH+ I+H ++K EN++ E + I+ I D S + I + P PEVL + + A+D W+IGV +ILLCGY PFY E T+L+ ++ A Y ++ + S + KDF+ ++++ P R + AL+HPW
Sbjct: 3 RQESDHMWKKST---ENIQEIFDLMEELG------SGAFSEVFMVRERKTGKKFAMKCIKKKKKRDINLENEMAVLRRIKHENVVGLEDIYESRTHYYLIMQLVSGGELFDRILDRGMYTEKDASRVIQQVLQAVSYLHQNGIVHRDLKPENILYYSQDEDSKIM-ISDFGLSKMTDTGIMS-TACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEESETKLFSKIMKAQYEFDSPFWDDISESAKDFIRNMMQKTPSMRYSTEQALRHPW 273
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk1db (calcium/calmodulin-dependent protein kinase type 1D [Source:NCBI gene;Acc:101175563]) HSP 1 Score: 145.976 bits (367), Expect = 9.546e-40 Identity = 86/284 (30.28%), Postives = 145/284 (51.06%), Query Frame = 2
Query: 50 RKKMDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
R + C K ++ V E F P +V GA S V + T K A+ I KK + N+I + K+ N++ + +++E+ H+ +I + ++G +LF+ + G YTE R+ +Q+L + YLH I+H ++K ENL+ + + I+ I D S + + P PEVL + + A+D W+IGV +ILLCGY PFY E ++L+ ++ ADY ++ + S++ KDF++ L++ DP+ R AL+HPW
Sbjct: 2 RSRQRCKSSKLNVAPHGVSE--------FTSP-EVSGAFSEVVMAREKATGKMVAIKCIPKKALKGKETSIENEIAVLRKIKHENIVALEDIYESSNHLYLIMQLVSGGELFDRIVEKGFYTEMDASRLIRQVLDAVNYLHSMGIVHRDLKPENLLYFSPHDDSKIM-ISDFGLSKMEGTGGVMATACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKADYEFDAPYWDDISDSAKDFISCLMEKDPEKRFTCDQALEHPW 275
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk1b (calcium/calmodulin-dependent protein kinase type 1 [Source:NCBI gene;Acc:101170017]) HSP 1 Score: 145.206 bits (365), Expect = 1.226e-39 Identity = 87/271 (32.10%), Postives = 143/271 (52.77%), Query Frame = 2
Query: 89 KNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDN---NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
+ +V+E YD EI GA S V + T K A+ I KK +N N+I + K+ N++ + ++FE+ +H+ +I + ++G +LF+ + G YTE ++ +QIL ++YLH+ I+H ++K ENL+ E + I+ I D S I + P PEVL + + A+D W+IGV +ILLCGY PFY E +L+ ++ A+Y ++ + S++ KDF+ HL++ D +R AL HPW
Sbjct: 13 RTTDVKEQYDF-KEILGT-----GAFSEVVLAEEKRTHKLVAIKCIPKKALEGKENSIENEIAVLHKIKHPNIVSLEDIFESKSHLYLIMQLVSGGELFDRIIEKGFYTEKDASKLIQQILDAVKYLHDMGIVHRDLKPENLLYYSMDEDSKIM-ISDFGLSKIEGSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVISYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIVHLMEKDSNTRYTCDQALLHPW 276
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000030766.1 (SMESG000030766.1) HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0 Identity = 292/333 (87.69%), Postives = 295/333 (88.59%), Query Frame = 2
Query: 59 MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMDDIRRANDIFDKLILRNPYRTY 1057
MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLND+NLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTE+ R NLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNALKDFLNHLLKA+PKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMDDIRRANDIFDKLILRNPYRTY
Sbjct: 1 MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDINLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTENIFTR-----------------------------------NLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFNCESTSNALKDFLNHLLKANPKSRMNIINALKHPWNEICIMKNQPLESIYQQYVKCVGSIEDRMHEKVMDDIRRANDIFDKLILRNPYRTY 298
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000042100.1 (SMESG000042100.1) HSP 1 Score: 186.808 bits (473), Expect = 6.930e-56 Identity = 103/290 (35.52%), Postives = 164/290 (56.55%), Query Frame = 2
Query: 59 MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKKVGYCPDNNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPWNEICIMKNQPLE 925
M+ YWIKDSIKN+ E+ Y+I ++I G+ V C + T FA VI KKV +++G+ LKL N++R+ EV+E+ T ++++ E+++G +LF+ G Y+E R +++L + YLHE +IIH ++K ENL+ E N LK+ D + I+ D++ +++ P C PE+LL +D+W+IGV +ILLCGYEPFY EK ++++ +I YS++ ++ S KD ++ LL DP R+ AL H W + K LE
Sbjct: 1 MEEYWIKDSIKNEPFEKYYEILNKIGN------GSTCTVYCCVRKRTDIKFAAKVISKKVNKKLIKSEVGVLLKLTHPNIIRLYEVYESATDVHMVLEYVSGGELFDRIVSRGFYSEKDASRCVREMLQAVSYLHENDIIHRDLKPENLLYESQEESN--LKLADFGIAKILEDDVHTMTVCGTPGYCAPEILLGVSYGKPVDLWSIGVITYILLCGYEPFYNEKDNQMFKNIIKGIYSFSSPWWDNVSLNAKDIISKLLVVDPHKRLTANQALNHVWVKGEGAKTSSLE 282
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000078937.1 (SMESG000078937.1) HSP 1 Score: 137.117 bits (344), Expect = 4.444e-37 Identity = 81/265 (30.57%), Postives = 131/265 (49.43%), Query Frame = 2
Query: 158 GALSVVSACYNRTTRKSFAVNVIKKKVGYCPD-----------------NNDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVL-LSQIRTFA--LDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYNFN-CESTSNALKDFLNHLLKADPKSRMNIINALKHPW 889
GA S V + R AV IKKK N+I + KL N++++++V E+ ++ E +TG +LF+ + G YTE + +Q+L Y+HE ++H ++K ENL+ + + I+ I D S + D + P PEVL ++ R++ +D WA+GV +ILLCGY PFY E EL+R + A Y ++ + S++ KDF+ HL++ +PK R + +L HPW
Sbjct: 19 GAFSEVRLAEDTEKRSFVAVKCIKKKAITASSRASNKDKQEAQAREDSLKNEISVLRKLKHENIVQLLDVLESDDTYYLVMELVTGGELFDRIVEKGSYTEKDASNLIRQVLEATDYMHEQGVVHRDLKPENLLYYSPDDDSKIM-ISDFGLSKMDDADSAMATACGTPGYVAPEVLEVNSGRSYGKEVDCWAVGVIAYILLCGYPPFYDENDQELFRQIKEAQYEFDSPYWDEISDSAKDFIKHLMEKNPKKRYSCKESLAHPW 282
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000011366.1 (SMESG000011366.1) HSP 1 Score: 114.005 bits (284), Expect = 1.629e-28 Identity = 79/269 (29.37%), Postives = 129/269 (47.96%), Query Frame = 2
Query: 104 EEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKK------VGYCPDN--NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYN-FNCESTSNALKDFLNHLLKADPKSRMNIINALKH 883
E+ Y +G I + G + V C N T +A IKKK +G D+ + I KL+ N++++ E F+ +I E +TG +LF + +E + + +QIL G+ ++H NI+H ++K EN+++ D +KI D S ++ D L + P PEV+ TFA DMW+IG+ +I+L G PFY E +E++ + N C S+ K FL+ L+ P R++ + LKH
Sbjct: 9 EQKYILGQHIGK------GHYATVKMCTNIETNIDYAAKFIKKKRIAMSRIGTKTDDIVREARILSKLSHPNIIQIYEAFDRKDMSVLILELVTGGELFEYISNKVTLSEEEASKFMRQILLGVHHMHSKNILHLDLKPENILVEDPDTQK--IKIIDFGFSKEIN-DAPILELQGTPEFVAPEVINYDPLTFATDMWSIGIIAYIMLTGNSPFYHETQSEVFNRITRCQLDLNDSTCSMMSDLAKSFLSSLIVKTPSKRLSCEDCLKH 268
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000011366.1 (SMESG000011366.1) HSP 1 Score: 113.62 bits (283), Expect = 2.445e-28 Identity = 79/269 (29.37%), Postives = 129/269 (47.96%), Query Frame = 2
Query: 104 EEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSFAVNVIKKK------VGYCPDN--NDIGIFLKLNDVNLMRVIEVFETWTHINVIREHLTGDQLFNHFKKSGPYTESKVGRITKQILSGIRYLHEYNIIHGNIKSENLIIVDSGEGNLILKICDHIQSTIMHYDIYRLSIIALPSLCPPEVLLSQIRTFALDMWAIGVCVFILLCGYEPFYREKITELYRAVITADYSYN-FNCESTSNALKDFLNHLLKADPKSRMNIINALKH 883
E+ Y +G I + G + V C N T +A IKKK +G D+ + I KL+ N++++ E F+ +I E +TG +LF + +E + + +QIL G+ ++H NI+H ++K EN+++ D +KI D S ++ D L + P PEV+ TFA DMW+IG+ +I+L G PFY E +E++ + N C S+ K FL+ L+ P R++ + LKH
Sbjct: 9 EQKYILGQHIGK------GHYATVKMCTNIETNIDYAAKFIKKKRIAMSRIGTKTDDIVREARILSKLSHPNIIQIYEAFDRKDMSVLILELVTGGELFEYISNKVTLSEEEASKFMRQILLGVHHMHSKNILHLDLKPENILVEDPDTQK--IKIIDFGFSKEIN-DAPILELQGTPEFVAPEVINYDPLTFATDMWSIGIIAYIMLTGNSPFYHETQSEVFNRITRCQLDLNDSTCSMMSDLAKSFLSSLIVKTPSKRLSCEDCLKH 268 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004608 ID=SMED30004608|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1094bpback to top protein sequence of SMED30004608-orf-1 >SMED30004608-orf-1 ID=SMED30004608-orf-1|Name=SMED30004608-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=337bp MDCYWIKDSIKNQNVEEIYDIGHEIFRCPFQVEGALSVVSACYNRTTRKSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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