Cytochrome P450 2K1-like protein

Query:  157 ITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFEN 1560
            + LG   + +   F  +   KN     GP   P +GN    + E   + +  + K YG+LF   +G    V+++   ++ + L     NF  R    + +   + +G++ +  + W  QR F L  LR+FG GK+  +E +  E   L + I+EE G+          A  N+I  +    RFE     F +L KL+++        L   +   + +  P+I  FL    G ++T     K    F++++ID H+K +N   E  DFID +LKE  K         +F ++ LI   L+LFFAG ETTSTTL W++L +A +PEIQEKV  EI  ++G  + P+ A ++ + YT AV+ E+ R+  ++PL++   V  +T + G ++PK ++I  NL A HRD   W  P  F P+HFL    +GQ K   R+  +PFSIGKR CLGE LAR E FIF T ++QKF  R  N
Sbjct:   21 LLLGTVAFLLAADFLKRRRPKNYP--PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVT-----YLEASKTCQLYNVFPWIMKFL---PGPHQTLFSNWKKLKLFVSHMIDKHRKDWN-PAETRDFIDAYLKEMSKHTGNPTS--SFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL---ENGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPN 475          

Query:  229 LLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSKFINNIID---DHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            L  GPT  P IGN    N E ++  L K S+ YG +F   +G R +V+L     + + L +Q   FSGR +        +  G+ F+  E     R F++  LR FG GK+  +E +  E   L+  +    G  +       +   NVI+ +V   RF+ + K+F  L +++  + Q        L++M+  ++ ++P          G  + A    + + + I    +H +R    N   DFID FL    +  EEK  N  F  + L+   L LFFAG ET STTL +  LLL KHPE++ KV++EI  ++G  + P F D+  + YT+AV+ EI R   ++P+ ++HRV ++T+    ++PK + +FP L +  RD   +  P +F P+HFL  +  GQ K +  D  VPFSIGKR C GEGLAR+E F+F T I+Q F+ +
Sbjct:   33 LPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLP----------GPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE--EEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFL--DKKGQFKKS--DAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFK 463          

Query:  205 QSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSKFINNIID---DHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            Q  SK   L  GPT  P IGN    N E ++  L K S+ YG +F   +G R +V+L     + + L +Q   FSGR +        +  G++F+  E     R F++  LRDFG GK+  +E +  E   L+  +    G  +       +   NVI+ +V   RF+   K+F  L +++    Q  +     L++M+  ++ ++P          G  + A    + + + I    +H +R    N   DFID FL    +  EEK  N  F  + L+   L LF  G ET STTL +  LLL KHPE++ KV++EI  ++G  + P F D+  + Y +AV+ EI R   V+P+S++ RV ++T+    ++PK + ++P L +  RD + +  P +F P+HFL  N  GQ K +  D  VPFSIGKR C GEGLAR+E F+F T ++Q F+++
Sbjct:   26 QRKSKG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLP----------GPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE--EEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL--NEKGQFKKS--DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463          

Query:  238 GPTGWPLIGNINSFNEPLWM------------------------VLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNN-NFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFL---KEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            GPT WPL+GN      P ++                        +L   ++ YGS+F + +G   +V+LS    + + L +Q   FS R +  LI   T+  G++F      W  QR F+   LR FG GK   +  +  E   +  ++++         S+   A  N+I  L    RF+  + +F ++   + + ++   N  + L  + P L  +PF  PF        +  K  + F+  II DH++  + EN  +DFID++L   +E+ K N     N +F ++ L  ++ +LF AG +TT+ +L W +L ++ +P++QEKV++EI  ++G  + P+  DK  + YT+A + E+ R++ VVPL+I H   ENT + G  IPK ++I PNL++ HRD  +WEKP +FYP  FL  ++ GQL    ++  +PF IGKR C+GE LA++E F+    ++Q F
Sbjct:   62 GPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPF-GPF----KELRQIEKDITSFLKKIIKDHQESLDRENP-QDFIDMYLLHMEEERKNNS----NSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFL--DDQGQL--IKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511          

Query:  229 LLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSKFINNIID---DHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            L  GPT  P IGN    N E +   + K+S+ YG +F   +G R +V+L     + + L +Q   FSGR +        +  G+ F+  E       FA+  LRDFG GK+  +E +  E   L++ I    G  +       +   NVI+ +V   RF+ + K+F  L  ++    Q  +     L++M+  ++ ++P          G  + A    + + + I    +H +R    N  +DFID FL   H   EEK  N  F  + L+   L LF AG ET STTL +  LLL KHPE++ KV++EI  ++G  + P F D+  + Y +AV+ EI R   V+P+S++ RV ++T+    ++PK + +FP L +  RD + +  P +F P+HFL  ++ GQ K +  D  VPFSIGKR C GEGLAR+E F+F T ++Q F+++
Sbjct:   33 LPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLP----------GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLI--HMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFL--DDKGQFKKS--DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKAR-TRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKD-FTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWS-----GRNKTAKITSK------FINNIIDDHKKRFNIEN-EGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            +L+ I   I LYF   F +     K  NL  GP   P +GN+ S    +P +     + K YG +F + M  +  VI++S + + +T  + G+ +  +      K R   N G+L T    W   R F L  LRD G GK   QE +  E   L K+++   G+ +    L  ++  NVI   + N RF+ D +D F  L  LI+              M  +     ++  +L+ W+     G   + K+ +K      F  + ID+H+   + +N E  DF++ +LKEQ K  EE     TF ++QL  ++ +L+ AG  TT+ T++W +     +PE+Q K+ +E+  ++G ++L + ADK  L Y QA + E  R + ++PL++ H    +T +DG  I K + +   +     DE V+ +P++F PE F  I N    K+   DE++PFSIGKRQCLGEGLARIE F+F   I  ++ +
Sbjct:    2 LLLLIFSSIFLYFFYHFHW-----KRRNLPPGPRPLPFLGNLLSLKTLKPGYEAFSNWKKEYGPIFTFWMANKPFVIIASYEKMKETFVKDGDTYVDKQLTHTEKERLGENYGVLDTNGHMWKEHRRFTLTQLRDLGLGKDLMQEKILMEVEELFKELDAHGGEEIDLPKLIDRSVGNVINLTLFNKRFDMDKRDEFAHLKSLIDG-------------MRNVTSQFRYLIQYLVPWTSTVLPGPTLSEKVRAKREELDDFFYSQIDEHRNEIDFDNTENLDFVEAYLKEQKK-REEDGDFKTFCNKQLCAMLFDLWIAGLMTTTMTMTWGLSYYLYNPEVQRKIREELDKVIGNDRLISTADKNDLPYLQAFVTETQRTANIIPLNLIHMTTRDTVIDGFPIQKGTGVIAQISTVMYDEKVFPEPYKFKPERF--IENG---KFKKVDEVIPFSIGKRQCLGEGLARIELFLFFANIFNRYDV 461          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPL--WMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIK-ARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSK-DFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLL--WWSGRNKTAKITS-KFINNIIDDHKKRFNIEN---EGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAP 1623
            ++I +   + +YF+ + ++     K  N   GP   P+ GN+ S   P   +    +++K YG ++ + +G    +++++   + +T     + ++ +    ++  +R    GI+ +    W   R FAL  +RDFG GK   QE +  E   +   ++ + G       +F  A  NV+ +L+   RF    + ++ EL  +I+   +    +     M     N+P  A  L    + G  KT + T+  F N  I+ H+ R + E+   E  DF++ FLKEQ K  E +  + T+++ QL+ V ++L+FAG  TT+ T++W++  +  HPE+Q+K+++E+  ++G+++L   ADK  L Y  A ++E  R   ++PL++ H    +T +DG  IPK + +   +     +E V+  P+ F P+ F  I+ +G+LK    DEL PFS+GKR C GEGLAR+E F+F+   + ++KI      S+E    + +G+ G + AP
Sbjct:    2 IIILLLTFLTIYFVYELYW-----KRRNFPPGPCPLPVFGNLLSIANPPPGYKAFERWTKKYGDVYTFWIGNTPHIMINTWDKIKETFIRDADTYTNKVVLPMVTLSRGGEYGIIDSNGAMWREHRRFALSTMRDFGLGKNLMQENILMEVQDVFARLDAKLGSETDVPEVFDHAVANVVNQLLFGYRFMGPKENEYQELKHIIDSPAEIFGKLHIFLAM-----NIPIFAKLLPESLYEGPIKTFRDTTLAFFNKQIEAHRHRIDFEDLNSESTDFVETFLKEQ-KRRESEGDSETYSNIQLLNVCIDLWFAGLNTTTNTITWAISYVLHHPEVQDKIHEELDKVIGSDRLITTADKNDLPYFNASINESQRGINILPLNLQHATTRDTVIDGFKIPKGTGVVAQISTVMNNEEVFPDPYTFNPDRF--IDENGKLKKV--DELAPFSVGKRSCPGEGLARMELFLFIANFLNRYKI----HPSKEGLPSMAKGS-GPVVAP 484          

Query:  193 FFFNQSASKNLNLLQGPTGWPLIGNINSFNEPL--WMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGR-FQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRF-ESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIE-NEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            F F+    K  N   GPT  PLIGN+ S   P   +    +++  YG ++ + +G R  +++SS + L +T  + G  ++ +    F    R  + G++ T   +W   R FA+   RDFG GK R ++ +  E   +  + ++  G+ V    +F +A  NVI +++   RF E+ + +F  +         +  F     ++   L  M +I P         K  K  ++F    I++HKK  + E  E  D+++ FLKEQ K  E      +F+ +QL  + L+L+FA   TTS T++W       + + Q+K+++E+  ++G+E+  N ADK  L YT A ++EI R + +VPL++ H    +T + G  IPK + +   +     DENV+ +P+ F PE FL  ++ G+LK    ++LVPFS+GKRQCLGEGLAR+E F+F+     ++++
Sbjct:   13 FLFHHLYWKRRNWPAGPTPLPLIGNLLSLRNPAPGYKAFARWTAKYGDIYTFWLGTRPYILVSSYEALKETFIKDGETYADKKPMAFQESFRGGSYGVVETNGPFWREHRRFAIHQFRDFGLGKDRMEQRIMLEVEDIFNNCDKTIGEGVDLTDIFDRAVGNVINQMLFGYRFDETRADEFRTIRAFFN--FNSGEFASFSMRVQFFLPWMGYIMPGPTILDRFKKYQKGFTEFFGTQIENHKKEIDFELEENSDYVEAFLKEQRK-REASGDFESFSTKQLSNMCLDLWFAALMTTSNTMTWCFAYTLNYLDAQQKLHEELDRVIGSERHINTADKPNLPYTNAYINEIQRTANLVPLNLLHMTTRDTVLKGYNIPKGTGVVAQISTVMYDENVFPEPYIFKPERFL--DDDGKLKKV--EQLVPFSVGKRQCLGEGLARMELFLFIANFFNRYRV 462          

Query:  142 FVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINS--FNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQ-NFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRF-ESDSKDFTELTKLIEKAIQNNNFI---LTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSK------FINNIIDDHKKRFNIENEGE-DFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            F+ IF  L    YF           K  NL  GPT  P +GN  S  +  P +    ++++ YG +F + +G    V++SS + + +T  + G  +  + Q +F  K R    G++ T    W+T R FA+   RD G GK   QE +  E   + + ++   G       +   A  NVI +++   RF ES+  +F +L  LI+  IQ  +F    L +    PI++ +           G++    I  K      F    I DH+ + N + E   D+ + +LKEQ    +  + +  F+DQQL  +  +L+FAG  TT+TT++W++  +  HPE+Q+K+ +E+  ++G+++L   +DK  L Y  AV++E  R   ++P ++ H    +T ++G  IPK + +   +     DE ++  P++F PE F  I+ +G LK    ++L+PFS+GKRQCLGEGLAR+E F+ +  +  ++ I
Sbjct:    7 FIAIFFWLAHCFYF-----------KRRNLPPGPTPLPFLGNSLSMIWENPGYECFRRWTRIYGDVFTFWLGDTPYVVISSLEKMKETFIKDGETYQDKIQFSFTEKFRGGRFGVIETTGHMWSTHRRFAISTFRDLGLGKNLMQEKILAEVEAVFQILDANLGAEQDVPEVIYNAVANVINQMIFGYRFDESNQNEFEKLKDLID--IQEKSFASFKLCVQAFVPIMNKL---------LPGKSLEDLIAEKRHDYYNFFYAQIQDHRAKINYQAEEYLDYAEAYLKEQKNQEQGGLGSDLFSDQQLANMCFDLWFAGLTTTNTTINWTISYVLNHPEVQDKMQEELDKVVGSDRLVTISDKSSLPYMNAVINESQRCVNLLPCNLFHATTRDTVINGNIIPKGTGVIAQISTVMLDEKIFPDPYKFQPERF--IDENGALKKI--EQLIPFSVGKRQCLGEGLARMELFLIVANLFNRYFI 463          

Query:  193 FFFNQSASKNLNLLQGPTGWPLIGNINS--FNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRF-QNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESD-SKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITS------KFINNIIDDHKKRFNIEN-EGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            F F++   K  NL  GP   P +GNI +   N+P +      +K YG ++ + MG+   V++SS  +L  T    G+ +  ++ Q    K R  N GI+ +    W+T R FAL  LRDFG GK   QE +  E   + K  + + G       +   A  NVI + +   RFE D  +DF +L +L+E   Q   F    F++Y +   +P +   L    GR+    +         F +  I++H+K+ + ++ E  D+ + +LKEQ K  E   +   F+++QL    L+L+ AG  TT+TT++W++  +  HP++ +K+ +E   ++G+++L    DK  L Y  AV++E  R + +VP+++ H   ++T ++G  + K + +   +     DE ++  P++F P+ F++ N     K    ++L+PFSIGKRQC GEGLAR+E F+FL     ++KI
Sbjct:   13 FLFHELYWKRRNLPPGPIPLPFMGNILTMLLNKPGYECFRNCTKKYGDVYTFWMGKTPFVMISSYDLLKDTFVRDGDTYKDKYPQPLNQKIRGGNYGIVESNGHLWSTHRRFALTTLRDFGLGKDLMQEKILIEVEDIFKKFDAQLGLEQDVSVVMNNAIANVINQNIFGYRFEGDKEEDFKKLRELME--YQETAF--ATFKVY-VEAFIPKVGALL---PGRSLNELLEEWRDNFYTFFDTQIENHRKKIDFDSQESLDYAEAYLKEQRK-QEALGEFELFSNKQLSNTCLDLWLAGLSTTNTTVNWTICYVLNHPDVLQKMNEEFDQVVGSDRLVTMGDKNNLPYFNAVLNESQRCANIVPINLFHATTKDTVINGYPVKKGTGVIAQISTVMLDEKIFPDPYKFNPDRFIDENG----KPIKIEQLIPFSIGKRQCPGEGLARMEMFLFLANFFNRYKI 462          

Query:  229 LLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGF-----GKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITS---KFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKV-------KNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            L  GP G P+IG +            + +K YGSLF   +G +  V++S  KM+ +  + +   F+GR     ++      GI+ +  + W  QR F    LR FG      GKQ+ Q+ +  E    +  +    G+ V    +   A  NVI  L+M+ RF  D   F     LIE+ ++       LF     +D +P +  F    + +NK A+  +   +F  ++IDDHK+ F+  N   D +D +L E  K   E         KNH   ++QL++V+++LF AG ET  TTL W  + + ++P+   +V  E+  ++G  +LP   D + L  T++ + E +R S++VPL+ +H    + E++G  IP  S + P + + H D N+WEKP EF P  F  I+  G+++    +  +PF +G+R CLG+ LAR+E F+F    +  F I     + E +     +G  G    P S  V  + R
Sbjct:   53 LPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQT-LNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMR-------LFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFD-PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH---EEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRF--IDTEGKVRKP--EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDI----ALPEGQPLPSLKGNVGATITPESFKVCLKRR 520          

Query:  229 LLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGF-----GKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITS---KFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKV-------KNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            L  GP G P+IG +            + +K YGSLF   +G +  V++S  KM+ +  + +   F+GR     ++      GI+ +  + W  QR F    LR FG      GKQ+ Q+ +  E    +  +    G+ V    +   A  NVI  L+M+ RF  D   F     LIE+ ++       LF     +D +P +  F    + +NK A+  +   +F  ++IDDHK+ F+  N   D +D +L E  K   E         KNH   ++QL++V+++LF AG ET  TTL W  + + ++P+   +V  E+  ++G  +LP   D + L  T++ + E +R S++VPL+ +H    + E++G  IP  S + P + + H D N+WEKP EF P  F  I+  G+++    +  +PF +G+R CLG+ LAR+E F+F    +  F I     + E +     +G  G    P S  V  + R
Sbjct:   53 LPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQT-LNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMR-------LFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFD-PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH---EEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRF--IDTEGKVRKP--EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDI----ALPEGQPLPSLKGNVGATITPESFKVCLKRR 520          

Query:  238 GPTGWPLIGN----------INSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNS--GILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKV------VSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFA-DKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENV----WEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFK-IRFENEISEE 1575
            GP  +P++G+          +  F + + +   +Y   YG  +   +G+  +VI  ++  + + +  +  +  GR      + RT NS  G+L T+ E W  QR F L+ L++FGF +    +IV NE   LL+D++++  K       +    L     +N +  ++   R+E  S + T+L +   +  +N + +  LF  +P+L    FIAP    ++G  ++ +    F++  I+ H+  +   +E  D +D +L+ Q + N+EK     F+DQ L+ + L++F AG ETT+ +L +  + L   PEIQE+ +QEI +++G E++P ++ D+  L Y +A+  E +R+  +    I HR   +T + G  IPKD+++     AC R   +    +  P  F P+ +L     G LK    +   PF  G+ +C+G+ L R   F+F T ++Q FK +    ++ EE
Sbjct:   30 GPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAISEMMTNE--DIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLR---FIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEK---GMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMV----IACFRGMLINPVDFPDPESFNPDRYL---FDGHLKLP--EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEE 481          

Query:  238 GPTGWPLIGN----------INSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNS--GILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKV------VSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFA-DKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENV----WEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFK-IRFENEISEE 1575
            GP  +P++G+          +  F + + +   +Y   YG  +   +G+  +VI  ++  + + +  +  +  GR      + RT NS  G+L T+ E W  QR F L+ L++FGF +    +IV NE   LL+D++++  K       +    L     +N +  ++   R+E  S + T+L +   +  +N + +  LF  +P+L    FIAP    ++G  ++ +    F++  I+ H+  +   +E  D +D +L+ Q + N+EK     F+DQ L+ + L++F AG ETT+ +L +  + L   PEIQE+ +QEI +++G E++P ++ D+  L Y +A+  E +R+  +    I HR   +T + G  IPKD+++     AC R   +    +  P  F P+ +L     G LK    +   PF  G+ +C+G+ L R   F+F T ++Q FK +    ++ EE
Sbjct:   30 GPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAISEMMTNE--DIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLR---FIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEK---GMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMV----IACFRGMLINPVDFPDPESFNPDRYL---FDGHLKLP--EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEE 481          

Query:  238 GPTGWPLIGNINSFNEPLWMVL--YKY--------SKHYGS-LFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNS---GILFTEKEWWATQRSFALKVLRDFGFGKQRSQ-EIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDS------------KDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAK---ITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            GP   PL G+       L+M++  +KY        S+ Y S +    +G   + ++ S+  + + L  Q   F GR Q F+   R       GI F +   W  QR F L+ LRDFGFG++  Q E+V  E +  + D+     K      +       V+  L+ N  F +++            ++  +L KL +  IQ         +M  I+   P+I      WSG NK  +      +F  + +D +   +  E    +F+D+++ E       +   + F   QLI  +++  F  +      LS  +  L  +P +  +V  EI +++G  +LPN  D+K L +T+A + E LR+ T+VP  + H+  E+TE+ G  IPKD+I+ P+L+A H D  +W  P +F PE FL+ +    LK    D  +PF  GKR C GE  AR   F+    + Q F
Sbjct:   32 GPPKIPLFGSY------LFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREILNNQ--VFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFN-PFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSII---PWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYE-EGVERNFMDVYIAEM-----RRGPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKL---DVSLPFGAGKRLCAGETFARNMLFLVTATMCQHF 475          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNE--PLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGK----QRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEK--AIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
             L+ + LG  L +++         +  +   GP   P  GN+   N   P+   L K+++HYGS++   +G +  V+L+  KM+ + L  Q   F+GR  + +I   TR+ G++  +  E W   R FAL  LR+FG GK    QR  E V + C++L    EE  GK +  + L+ +A  N+IA ++   RF    + F  L + +EK   I    + + L+++ P+L   P   PF   W   +   KIT ++   ++++HKK F +  E +D ID +L+E  K  +++    TF + Q++ ++ +LF AG ETTS TL    L L  H  IQE+  +EI ++LG      + D+  + + QAV+ E  RV+ +VPL++ H    +T++ G  IPK +II P L +  R+E+ W+ P EF P++FLN       ++   +  +PFS G R CLGE LAR+E F+ L  +++KF++ +  +  E +F  I  GT      P+    + ELR
Sbjct:    4 ALVLLCLGAILLYLQV-----RIRRPKDFPPGPAPVPFFGNLLQLNRINPI-KDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLL----EESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDEYFQTLIQTMEKLTKIAIGTWAM-LYEIAPVLRIFPL--PF---WKAFHYFEKIT-RYSLKVVEEHKKSF-VAGEPKDLIDCYLEEMKKRADQRT---TFDEAQMVTLLFDLFLAGTETTSNTLRTLTLYLMTHTHIQEQCQREIDEVLGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQLRGYSIPKGTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKG----EFVKNEAFMPFSAGPRVCLGENLARMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPM----IVELR 486          

Query:  238 GPTGWPLIGNINSFNE--PLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGK----QRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEK--AIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            GP   P  GN+   N   P+   L K+++HYGS++   +G +  V+L+  KM+ + L  Q   F+GR  + +I   TR+ G++  +  E W   R FAL  LR+FG GK    QR  E V + C++L    EE  GK +  + L+ +A  N+IA ++   RF    + F  L + +EK   I    + + L+++ P+L   P   PF   W   +   KIT   +  ++++HKK F +  E +D ID +L+E  K  +++    TF + Q++ ++ +LF AG ETTS TL    L L  H  IQE+  +EI ++LG      + D+  + + QAV+ E  RV+ +VPL++ H    +T++ G  IPK +II P L +  R+E+ W+ P EF P++FLN       ++   +  +PFS G R CLGE LAR+E F+ L  +++KF++ +  +  E +F  I  GT      P+    + ELR
Sbjct:   30 GPAPVPFFGNLLQLNRINPI-KDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLL----EESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDEYFQTLIQTMEKLTKIAIGTWAM-LYEIAPVLRIFPL--PF---WKAFHYFEKITRHSLK-VVEEHKKSF-VAGEPKDLIDCYLEEMKKRADQRT---TFDEAQMVTLLFDLFLAGTETTSNTLRTLTLYLMTHTHIQEQCQREIDEVLGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQLRGYSIPKGTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKG----EFVKNEAFMPFSAGPRVCLGENLARMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPM----IVELR 486          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNE--PLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGK----QRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEK--AIQNNNFILTLFQMYPILD--NMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGT 1602
             L+ + LG  L +++         +  N   GP   P+ GN+   N   P+   L K+++HYGS++   +G +  V+L+  KM+ + L  QG  F+GR    ++   TR+ G++  +  E W   R FAL  LR+FG GK    QR  E V + C++L    EE  GK +  + L+ +A  N+IA ++   RF+   + F  L   +EK   I    + + L+++ P+L    +PF   F  +    N   K+        +++HK    +  E  D ID +L+E   +N    K+ TF + Q++ ++ +LF AG ETTS TL    L L  +  IQE+  +EI ++LG      + D+  + + QAV+ E  RV+ +VPLS+ H    +T++ G  IPK +II P L +  R+E  W+ P EF P++FLN       ++   D  +PFS G R CLGE LAR+E F+ L  +++KF++ +  +  E +F  I  GT
Sbjct:    4 ALVLLCLGAFLLYLQ-----LRIRRPRNFPPGPAPVPIFGNLLQLNHINPI-KDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVSHVTRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLL----EESAGKPIDPQHLYHQAASNIIASIIFRSRFDYQDEYFQTLITTMEKLTKIAIGPWAM-LYEIAPVLRIFPLPFHKAFQYFEQITNHVLKV--------VEEHKTS-RVAGEPRDLIDCYLEE---MNRRSDKHTTFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIVPLSMFHTARTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKG----EFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVLRKFRLVWPKDAEEPDFTYIYGGT 473          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNE--PLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGK----QRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEK--AIQNNNFILTLFQMYPILD--NMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
             L+ + LG  L +++         +  N   GP   P+ GN+   N   P+   L K+++HYGS++   +G +  V+L+  KM+ + L  QG  F+GR    ++   TR+ G++  +  E W   R FAL  LR+FG GK    QR  E V + C++L    EE  GK +  + L+ +A  N+IA ++   RF+   + F  L   +EK   I    + + L+++ P+L    +PF   F  +    N   K+        +++HK    +  E  D ID +L+E   +N    ++ TF + Q++ ++ +LF AG ETTS TL    L L  +  IQE+  +EI ++LG      + D+  + + QAV+ E  RV+ +VPLS+ H    +T++ G  IPK +II P L +  R+E  W+ P EF P++FLN       ++   D  +PFS G R CLGE LAR+E F+ L  +++KF++ +  +  E +F  I  GT      P+    + ELR
Sbjct:    4 ALVLLCLGAFLLYLQ-----LRIRRPRNFPPGPAPVPIFGNLLQLNHINPI-KDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVSHVTRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLL----EESAGKPIDPQHLYHQAASNIIASIIFRSRFDYQDEYFQTLITTMEKLTKIAIGPWAM-LYEIAPVLRIFPLPFHKAFQYFEQITNHVLKV--------VEEHKTS-RVAGEPRDLIDCYLEE---MNRRSDQHTTFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIVPLSMFHTARTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKG----EFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPM----IVELR 486          

Query:  142 FVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMV-----------------------LYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMIL---LKDIEEECGKV-VSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQ-HKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            FVL+F       Y ++++ ++Q+ +   N+  GP  WP++GN   F  P +++                       L + SK YG++F   +G + +V+L+    +   +      FS R    L+   T+  GI+F      W T R F    LR FGFG+   +  +     I+   L+ + E  G   +    L   A  N+I+ + +  RF  + K+F  +  L+   ++ + N  + L  ++P L    +  PF ++   R     IT+ F+  II  H+   + EN   DFID++L E   K  E   + + F++  L  ++ +LF AG +TT+ ++ WS+L ++ +P++QEKV +EI  ++G+E++P+  DK  L YT+A + E++R++ VVPLSI H   E TE  G  IPK ++I PNL++ HRD  VWE P +F P  FL+     Q K   +D  +PF +G+R C+GE LA++E F+  T ++Q F  RF     E   A    G  G   AP    V  + R
Sbjct:   24 FVLVF-------YVLQEYQWHQTYA---NIPPGPKPWPIVGNFGGFLVPPFILKRFVKNSKEFAKVVSNPLSPQAGLIEMSKLYGNIFSIFVGPQLMVVLTGYDAVRDAMLNHTETFSDRPHIPLVTIITKRKGIVFAPYGPLWRTNRRFCHSTLRSFGFGRMSLEPCIHEGLAIIKTELQSLIETAGPSGIDLTPLISNAVSNIISLMSLGQRFHHEDKEFRNMRDLMSHGLEISVNTSILLVNVFPWL----YYLPFGVFKELRRAELDITA-FLKRIIARHRATLDPENP-RDFIDMYLVEMLAKQKEGSSEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAVVGSERVPSLTDKSSLPYTEATIMEVIRMTVVVPLSIPHMASETTEFRGFTIPKGTVIIPNLWSVHRDPTVWENPDDFNPSRFLD----DQGKILRKDCFIPFGLGRRVCMGEQLAKMELFLMFTSLMQTFTFRF----PEGATAPSMHGRFGLTLAPCPFTVCVKTR 533          

Query:  226 NLLQGPTGWPLIGNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSK----FINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            N   GP GWPL+GN+ S +       Y + SK YG +F   MGR+ +VIL   + +   L      F GR    + K   +  G++F+  E W   R F +  L+DFG GK   +E +++EC  L++      GK     ++   +  N+I  +++  R E +   F  L  L  + ++   + ++T++ M+P L  +P          G +KT K   K    F+     +++K+F+I ++   FID+FL  Q +  +       F ++ L+R+V  LF AG ETTST L W++LL+ K+P+IQEKV+ EI  ++G+   P ++ +  + +T AV+ EILR + +VPLS+ H    +    G +IPK + I P L +  +D+  ++ P +F P HFL+     +  +  ++  +PFS G+R C GE LAR+E FIF T ++QKF  R
Sbjct:   31 NFPPGPKGWPLVGNVFSIDLKKPQRTYIELSKKYGPVFSVQMGRKKMVILVGYETVKDALVTHAEEFGGRAYIPVTKDLEKGLGMIFSNGENWKAMRRFTITTLKDFGMGKSTIEETIAHECSYLVQYFASFKGKPFDNSTILITSVANIIVAILLGHRMEYEDPVFLRLVNLNSEYVKLLGSPMVTIYNMFPALGFLP----------GCHKTVKKNLKELYAFLKRTFVEYQKKFDIHDQ-RSFIDVFLARQKEEAKHPETYSYFHNENLVRLVRNLFSAGMETTSTALRWALLLMIKYPDIQEKVHDEISRVIGSVH-PTYSHRTQMPFTNAVIHEILRFADIVPLSVPHETTRDVHFKGYFIPKGTYIIPLLTSVLKDKTQFDAPEQFNPNHFLD----SEGNFLKKEAFMPFSAGRRACPGEILARMELFIFFTSLLQKFSFR 462          

Query:  109 KIWKTTKFMDNFVLIFITLGIAL--YFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFE-SDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            K+   T F+   +L+++   I L  Y +K F      +  L +  GP  +P IGN+N  N  +P   ++    ++Y  +F    G + +V+L+  K +   L  Q ++F  R +  +    T  +GI+F+  E W   R F L  LRDFG GK+  +  + +E   L+K  +   GK    + +   A  NVI  ++   RFE +D+   T L  L E A       L LF  YP+L ++      +L  + R K       F  N I++H+  FN  N    FID +L +Q +      K H F D+ L+  VL+LF AG ET+STTL W  LL+ K+PEIQ+KV +EI +++   +LP   D++ + YT AV+ EI R + +VP+++S     +    G  IP+ + + P L +   D N W+ P EF P+HFL+ N     K+  RD  +PFS G+R C+GE LA++E F+F TG++Q F +
Sbjct:    2 KMSYITHFVSTDILVYLATCITLLLYLLKGF-----KNSALKMPPGPAPFPFIGNLNILNLKKPFQSLMK--VRYYLKIFTVHFGPKKMVVLAGYKAVKDALVTQADDFGERAEMPIFSKLTHGNGIVFSNGESWKVIRRFTLSTLRDFGMGKRTIETRIQDELRPLIKLFKSHAGKPFDPKIILNSAVSNVICSIIFGKRFEYNDTTFLTLLQLLNENARLFGTPPLLLFNFYPLLGSILGAHKRVLRNTERLK------HFFQNYINEHRAEFNANNI-TGFIDAYLLKQEQ-ESSNAKTH-FHDENLVYSVLDLFAAGTETSSTTLRWGFLLMMKYPEIQKKVQKEIKEVVRPGQLPKVEDRRNMPYTDAVIHEIQRFANIVPMNVSRATVRDVNFRGFLIPRGTEVIPMLTSVLYDNNHWKTPHEFNPQHFLDANG----KFVQRDAFLPFSTGRRACVGESLAKMELFLFFTGLLQSFTL 466          

Query:  124 TKFMDNFVLIFITLGIAL--YFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKI 1548
            T F+   +L+++   I L  Y +K F      +  L +  GP  +P IGN+N  N  L        K YG +F    G + +V+L+  K +   L  Q ++F  R +  +    T  +GI+F+  E W   R F L  LRDFG GK+  +  + +E   L+K  +   GK    + +   A  NVI  ++   RFE     + + T L    + N N    LF   P+L                     +T  F  N I++H+  FN  N    FID +L +Q +      K H F D+ L+  VL+LF AG ET+STTL W  LL+ K+PEIQ+KV +EI +++   +LP   D++ + YT AV+ EI R + +VP+++S     +    G  IP+ + + P L +   D N W+ P EF P+HFL+ N     K+  RD  +PFS G+R C+GE LA++E F+F TG++Q F +
Sbjct:    5 THFVSTDILVYLATCITLLLYLLKGF-----KNSALKMPPGPAPFPFIGNLNILN--LKKPFQSLMKKYGEVFTVHFGPKKMVVLAGYKAVKDALVTQADDFGERAEMPIFSKLTHGNGIVFSNGESWKVIRRFTLSTLRDFGMGKRTIETRIQDELRPLIKLFKSHAGKPFDPKIILNSAVSNVICSIIFGKRFE-----YNDTTFLTLLQLLNEN--ARLFGTPPLL---------------------VTLHFFQNYINEHRAEFNANNI-TGFIDAYLLKQEQ-ESSNAKTH-FHDENLVYSVLDLFAAGTETSSTTLRWGFLLMMKYPEIQKKVQKEIKEVVRPGQLPKVEDRRNMPYTDAVIHEIQRFANIVPMNVSRATVRDVNFRGFLIPRGTEVIPMLTSVLYDNNHWKTPHEFNPQHFLDANG----KFVQRDAFLPFSTGRRACVGESLAKMELFLFFTGLLQSFTL 439          

Query:  226 NLLQGPTGWPLIGNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSK----FINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            N   GP GWPL+GN+ S +       Y + SK YG +F   MGR+ +VIL   + +   L      F GR    + K   +  GI F+  E W   R F +  L+DFG GK   +E +++EC  L++      GK     ++   +  N+IA ++   R E +   F  L  L  + ++   + ++T++ M+P L  +P          G +KT +   K    F+     +H+K  +I ++   FID+FL  Q +  +       F ++ L+R+V  +F AG ETTST+L W++LL+ K+P+IQEKV+ EI  ++G+   P ++ +  + +T AV+ EILR + +VPLS+ H    +    G +IPK + I P L +  +D+  ++ P EF P HFL+     +  +  ++  +PFS G+R C GE LAR+E FIF T ++QKF
Sbjct:   31 NFPPGPKGWPLVGNVFSIDLKKPQRTYIELSKKYGPVFSVQMGRKKMVILVGYETVKDALVTHAEEFGGRASIPVNKNLEKGLGITFSNGENWKAMRRFTITTLKDFGMGKSTIEETIAHECSYLVQYFASFKGKPFDNSTILSTSVANIIAPILFGHRMEYEDPVFLRLVNLNSEYVKLLGSPMVTIYNMFPALGFLP----------GCHKTIEKNLKELYAFVRRTFVEHQKHLDIHDQ-RSFIDVFLARQKEEAKHPETKSYFHNENLVRLVRNVFSAGMETTSTSLRWALLLMIKYPDIQEKVHDEISRVIGSAH-PTYSHRTQMPFTNAVIHEILRFADIVPLSVPHETTRDVHFKGYFIPKGTYIIPLLSSVLKDKTQFDAPEEFNPNHFLD----SEGNFLKKEAFMPFSAGRRACPGEILARMELFIFFTSLLQKF 459          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSK----FINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHT-FTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            V + +++ I ++  K F+  +   +N     GP   PLIGN++  N +   +   + ++ YGS++   +G RD+V+L  +  +   L      FSGR +  +    +   GI+F   E W   R F L  LRDFG GK+  ++ +S E   L+   +   GK      +   A  N+I  +++N RFE       +L K++ + I+   + I+ L+  YP +         + W  GR+KT    +     F+      H++  ++ N+  D ID+FL +Q    EEK+ +   F D+ L  ++  LF AG ETTSTTL W +LL+ K+PE+Q+KV  +I  ++G+ + P    +K + YT AV+ EI R + + P ++ H   ++    G +IPK + I P L +  RD+  ++KP EFYPEHFL+ + +    +   +  +PFS GKR C GE LA++E F+F T ++Q F
Sbjct:    4 VSVLLSVVICIFLYKIFYGGKETPENSP--PGPKPLPLIGNLHMINMKKPHLTFMELAEKYGSVYSVKLGTRDVVVLCGTDTVRDALINHAEEFSGRAKIPVFDEVSNGHGIVFAHGENWKVMRRFTLSTLRDFGMGKKTIEDRISEESDCLVGVFKSYEGKPFDNTMIMNAAVANIIVHILLNHRFEYQDPTLLKLIKIVSENIRIGGSPIVMLYNTYPSI---------MRWIPGRHKTVGANTAKLYDFLKETFTRHREHLDV-NDQRDLIDVFLVKQQ---EEKLSSTKFFHDENLTVLLGNLFGAGMETTSTTLRWGLLLMMKYPEVQKKVQDDIDRVIGSAE-PRLEHRKLMPYTDAVIHEIQRFANIAPTNVPHATTKDVTFRGFFIPKGTQIMPLLTSVLRDKAYFKKPEEFYPEHFLDSDGN----FVKNEACLPFSAGKRSCAGETLAKMELFLFFTKLLQNF 456          

Query:  154 FITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNI--NSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSK---FINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRG 1599
             +   +    +  +F N+      N   GP G P +GNI    F +P  + +    K YG++F   +G    V+++   ++ + L +   N   R  + + +  +  +G++F+  + W  QR FAL  LR+FG GK+  +E +  E   L++ I EE GK  +       A  N+I  +    RF+     F E+ +L+++ +      I  L+ ++P I+  +P             K  +   K   F++ +IDDH+K +N  +E  DFID FLKE  K  E   K  +F ++ LI   L+LFFAG ETTSTTL W++L +A +PE+QEKV  EI  ++G ++    AD++ + YT AV+ E+ R+  ++PL++   V  +T ++G ++PK +++  NL A HRD   W  P  F PEHFL    +GQ K   R+  +PFS+GKR CLGE LAR E FIF T ++QKF   F   I+E+   K   G
Sbjct:   21 LLVAAVTFLLLADYFKNRRPK---NYPPGPWGLPFVGNIFQLDFGQP-HLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIP---------GSHQKVFRNWEKLKLFVSCMIDDHRKDWN-PDEPRDFIDAFLKEMTKYPE---KTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFL---ENGQFKK--RESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFT--FNPPINEKLSPKFRNG 485          

Query:  241 PTGWPLIGNINSFNEPL---WMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKA--IQNNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKIT----SKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            P   P +GN  SF   L    + + K+ K YG++     G +  VI+SS  ++ +       NF  R    L +     +G++F+  + W  QR FAL  LR+FG GK+  +  +  E   L++ I EE G+          A  N+I  +    RFE     F EL +L++KA  +   + ++ L+ ++P I  ++P          G+++T   T      +I +IID+H+K +N  +E  DFID FL E  K   +     +F ++ LI   L+LF AG ETTS+TL W++L +A +PE+QE V  EI  ++G  K P+ AD+  + YT AV+ EILR+   VPL+I   V  +T + G ++PK S++  NL A H D   W  P  F PEHFL    +GQ K   R+  +PFS+GKR CLGE LAR E FIF T ++QKF  +
Sbjct:   47 PPRLPFVGN--SFQMDLTQSHLAVQKFVKKYGNVISLDFGIKSAVIISSLPLIKEAFSHLDENFINRRIFPLQRQIFNGNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEHRIQEEASHLVEAIGEEEGQPFDPHFKIYSAVSNIICSITFGERFEYHDSQFQELLQLLDKAMYLGTTSLMVHLYNIFPWITKHLP----------GQHQTLLATWRKLKSYIADIIDNHRKDWN-PDEPRDFIDAFLNEMAKYPGKTTT--SFNEENLICSTLDLFLAGTETTSSTLRWALLYMALYPEVQENVQAEIDRVIGQSKHPSLADRDSMPYTNAVVHEILRMGNSVPLNIPREVAVDTTLAGFHLPKRSVVMTNLTALHMDPKEWATPDIFNPEHFL---ENGQFKK--RESFLPFSMGKRACLGEQLARSELFIFFTALVQKFTFK 473          

Query:  226 NLLQGPTGWPLIGNINSFN---EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKART---RNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            N   GP   P +GN+  F+     L + +  + K YG+L     G    VI+S   ++ + L   G NF  R    ++ AR    +N+GI+ +  + W  QR F L +L++FG GK+  ++ + +E   L++ I EE G+      +   A  N+I  + +  RFE +   F EL KL ++ +    + +L L+ ++P I   +P   P    +S   K       F ++++D H+K +N  +   DFID FL E  K +++     +F ++ LI   L+LFFAG ETTST L W++L +  +PE+QEKV+ EI  ++G  + P   D+  + YT AV+ E+LR+  ++PL++   V  +  + G ++PK +++  NL A HRD   W  P  F PEHFL    +GQ K   R+  +PFS+GKR C GE LAR E F F T ++QKF  +
Sbjct:   42 NYPPGPWRLPFVGNLFQFDLDVSHLHLGIQPFVKKYGNLISLDFGTIPSVIISGEPLIKEALTCMGQNFLKRP---ILAARQHIFKNNGIISSSGQTWKEQRRFTLMILKNFGLGKKSLEQRIQDEAHHLVEAIAEEKGRPFDPHFMINNAVSNIICSITIGERFEYEDNQFQELLKLADETLCLEASKVLMLYNVFPSIFKYLP--GPHQKLFSNWEKL----KLFFSHVMDSHRKDWN-PSAPRDFIDAFLTEMAKYSDKTTT--SFNEENLICTTLDLFFAGTETTSTALRWALLYITVNPEVQEKVHSEIDRVIGQGRHPTIDDRDSMPYTNAVIHEVLRMGNIIPLNVPREVEADITLAGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFL---ENGQFKK--RESFLPFSVGKRGCPGEQLARSELFTFFTALMQKFTFK 474          

Query:  151 IFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            I +   +   F+  F  N+      N   GP   P +G +   +  +P  + L ++ K YG++          V+++   ++ +   +  +NF  R    L K     +G++F+  + W  QR FAL  LR+FG GK+  +E +  E   L++ I +E G+          A  N+I  +    RF+     F E+ +L+++A+   ++ +  L+ ++P IL  +P          G ++T     +    F+++I+++H++ ++  +E  DFID FL E  K  ++     +F ++ LI   L+LFFAG ETTSTTL W++L +A +PE+QEK+  EI  ++G  + PN AD+  + YT AV+ E+ R+  ++P ++   V  +T++ G  +PK  ++  NL A HRD + W  P  F PEHFL    +GQ K   R+  +PFS+GKR CLGE LAR E FIF+T + QKF  +
Sbjct:   20 ILLLSAVTFLFLADFLKNRRPK---NYPPGPMRLPFVGCLFHLDPKQP-HLSLQQFVKKYGNVLSLDFANIPSVVITGMPLIKEIFTQMEHNFMNRPVTLLRKHLFNKNGLIFSSDQTWKEQRRFALMTLRNFGLGKRSLEERIQEEAHYLVEAIRDEGGQPFDPHFNISNAVSNIICSITFGERFDYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLP----------GSHQTLFRNWRKLQLFVSDIVNNHRRDWD-PDEPRDFIDAFLTEMTKYPDKTTT--SFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRVIGQARQPNLADRDSMPYTNAVIHEVQRMGNIIPFNVPREVAVDTQLAGFNLPKGIMVLSNLTALHRDPSEWTTPDTFNPEHFL---ENGQFKK--RESFLPFSMGKRACLGEQLARSELFIFITTLFQKFTFK 472          

Query:  226 NLLQGPTGWPLIGNINSFN---EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILT-LFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRG 1599
            N   GP   P +GN+  F+     L + +  + K YG++     G    VI+S   ++ + +     NF  R      +   +N+GI+F+  + W  QR FAL +L++FG GK+  ++ +  E   L+K I EE G+          A  N+I  ++   RFE D   F EL KL ++ I +   +++ L+ ++P I   +P   P    +S   K       F++ ++D H++ +N  +   DFID FL E  K  ++     +F ++ LI   L+LFFAG ETTS TL W++L +  +PE+QEKV+ EI  ++G  + P   D+  + YT AV+ E+LR+  ++PL++   V  ++ + G Y+PK +++  NL   HRD   W+ P  F PEHFL    +GQ K   ++  +PFS+GKR C GE LA  E FIF T ++QKF   F++ I+E+   K   G
Sbjct:   42 NYPPGPRRLPFVGNLFQFDLDVSRLHLGIQPFVKKYGNVISVNFGYISSVIISGLPLIKEAITGMEQNFLKRPSLAARQHVFKNNGIVFSSGQTWKEQRKFALTILKNFGLGKKSLEQCIQEEAYHLVKAIGEEKGQPFDPHFRINNAVGNIICSIIFGERFEYDDNQFQELLKLADEIICSEASMMSVLYNVFPSIFKYLP--GPQQKLFSNWEKL----KLFVSRMMDSHREDWN-PSAPRDFIDAFLTEMTKYPDKTTT--SFNEENLICTALDLFFAGTETTSNTLRWALLYITVNPEVQEKVHSEIDRVIGHGRHPTLDDQDSMPYTNAVIHEVLRMGNIIPLNVPREVTADSTLAGFYLPKGTMVLINLTDLHRDPKEWDTPNVFNPEHFL---ENGQFKK--KESFLPFSMGKRACPGEQLASCELFIFFTALMQKFT--FKSPINEKPSLKFRMG 488          

Query:  154 FITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNI--NSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTAKITSK---FINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRG 1599
             +   +    +  +F N+      N   GP G P +GNI    F +P  + +    K YG++F   +G    V+++   ++ + L +   N   R  + + +  +  +G++F+  + W  QR FAL  LR+FG GK+  +E +  E   L++ I EE GK  +       A  N+I  +    RF+     F E+ +L+++ +      I  L+ ++P I+  +P             K  +   K   F++ +IDDH+K +N  +E  DFID FLKE  K  E   K  +F ++ LI   L+LFFAG ETTSTTL W++L +A +PE+QEKV  EI  ++G ++    AD++ + YT AV+ E+ R+  ++PL++   V  +T ++G ++PK +++  NL A HRD   W  P  F PEHFL    +GQ K   R+  +PFS+GKR CLGE LAR E FIF T ++QKF   F   I+E+   K   G
Sbjct:   21 LLVAAVTFLLLADYFKNRRPK---NYPPGPWGLPFVGNIFQLDFGQP-HLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIP---------GSHQKVFRNWEKLKLFVSCMIDDHRKDWN-PDEPRDFIDAFLKEMTKYPE---KTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFL---ENGQFKK--RESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFT--FNPPINEKLSPKFRNG 485          

Query:  238 GPTGWPLIGN---INSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGR-----FQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAI-QNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKE--QHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFK 1545
            GP  WP++GN   ++  N P  M  YK    YG +F   MG + +V+++  K + + L   G + + R     FQ+     + +   +L      W  QR F++  LR+FG GK+  ++ V++E   L   +  E G+ +   +L  KA  NVIA L+   RF+    DF ++ K++++++ +       +  M+P+L  +P +A  +          K     ++N++ +HKK ++ +    D  D FL E  + K N E     +F D  L  VV +LF AG  TTS TL+W++LL+  HP++Q +V QEI +++G  + P  AD+  + +T AV+ E+ R + +VP+++ H+   + EV G  IPK + + PNL +  +DE VWEKP  F+PEHFL+     Q  +   +  +PFS G+R CLGE LAR+E F+F T ++Q+F 
Sbjct:   39 GPVPWPVLGNLLQVDLCNMPYSM--YKLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTADRPEMPIFQHIGYGHKAKGV-VLAPYGPEWREQRRFSVSTLRNFGVGKKSLEQWVTDEASHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKESMGEQTGLFPEVLNMFPVLLRIPGLADKVF------PGQKTFLTMVDNLVTEHKKTWDPDQPPRDLTDAFLAEIEKAKGNPES----SFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRVQQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLD----AQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFS 468          

Query:  226 NLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQM-YPILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
             L  GPT  P IGN    N E ++  L K S+ YG +F   +G R IV+L   + + + L +Q  +FSGR +        +  G++F+  E     R FA+  LRDFG GK+  +E +  E   L++   +  G  +       +   NVI+ +V   RF+ + K+F  L +++  + Q        L++M Y ++ ++P          G  + A    +    FI   ++ +++  +  N   DFID FL    +  E+K     F  + L+   L LFFAG ET STT+ +  LLL KHP+++ KV++EI  ++G  + P F D+  + YT+AV+ EI R + ++P+ ++HRV  +T+     +PK + +FP L +  +D   + KP EFYP+HFL  +  GQ K +  D  +PFS+GKR CLGEGLAR+E F+F T I+Q F+ R
Sbjct:   32 KLPPGPTPLPFIGNYLQLNTEQMYDSLMKISERYGPVFTIHLGPRRIVVLCGQEAVKEALVDQAEDFSGRGELATFDWLFKGYGVVFSSWERARPLRRFAISTLRDFGVGKRGIEERIQEEAGFLIEAFRDTRGAFIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATPTGQLYEMFYSVMKHLP----------GPQQQAFKELEGLRDFIAKKVERNQRTLD-PNSPRDFIDSFLIRMQE--EKKDPKSEFHMKNLVMTTLNLFFAGTETVSTTMRYGFLLLMKHPDVEAKVHEEIDRVIGRNRQPKFEDRAKMPYTEAVIHEIQRFTDMIPMGLAHRVTRDTKFRDFLLPKGAEVFPMLGSVLKDPKFFSKPREFYPQHFL--DEKGQFKKS--DAFMPFSVGKRYCLGEGLARMELFLFFTTIMQNFRFR 463          

Query:  151 IFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYP-ILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            I +   +   F+  F  ++      N   GP   PL+G +   +  +P  + L ++ K YG++          V+++   ++ +   +  +NF  R    L K     +G++F+  + W  QR FAL  LR+FG GK+  ++ +  E   L++ I++E G          KA  N+I  +    RFE     F E+ +L+++A+   ++ +  L+ ++P IL  +P          G ++T     +    FI++II +H++ ++  +E  DFID FLKE  K  ++     +F ++ LI   L+LFFAG ETTSTTL W++L +A +PE+QEK+  EI  ++G  + PN AD+  + YT AV+ E+ R+  ++P ++   V  +T + G  +PK ++I  NL A HRD   W  P  F PEHFL    +GQ K   R+  +PFS+GKR CLGE LAR E FIF+T +IQKF  +
Sbjct:   20 ILLLAAVTFLFLADFLKHRRPK---NYPPGPWRLPLVGCLFHLDPKQP-HLSLQQFVKKYGNVLSLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQEEAYHLVEAIKDEGGLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLP----------GSHQTLFSNWRKLKLFISDIIKNHRRDWD-PDEPRDFIDAFLKEMAKYPDKTTT--SFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFNLPKGTMILTNLTALHRDPKEWATPDTFNPEHFL---ENGQFKK--RESFLPFSMGKRACLGEQLARSELFIFITSLIQKFTFK 472          

Query:  157 ITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            + LG   +    +F      KN     GP   P +GN+ + + E   + L ++ K YG+LF   +  + IVI++   ++ + L     NF  R    + +   + +G++ +  + W  QR FAL  LR+FG GK+  +E +  E   L + +E+E G+   A      A  N+I  +    RFE     F EL KL ++ +     +L   Q+Y I    P+I  FL    G ++T     K    F++ ++++HKK +N   E  DFID +LKE  K         +F ++ LI   L+LF AG ETTS      + + A +PEIQEKV+ EI  ++G  + P+ A ++ L YT AV+ E+ R+  ++PL++   V  +T + G ++PK +++  NL A H+D   W  P  F PEHFL    +GQ K   ++  +PFSIGKR CLGE LA+ E FIF T ++QKF  +
Sbjct:   21 LLLGAVAFLFFAYFLKTRRPKNYP--PGPWRLPFLGNLFTLDMEKSHLQLQQFVKKYGNLFCLDLAGKSIVIVTGLPLIKEVLVHMDQNFINRPVPPIRERSFKKNGLIMSSGQLWKEQRRFALMTLRNFGLGKKSLEERIQEEARHLTEAMEKEGGQPFDAHFKINNAVSNIICSITFGERFEYHDGQFQELLKLFDEVMYLEASMLC--QLYNIF---PWIMKFL---PGAHQTLFSNWKKLELFVSRMLENHKKDWN-PAETRDFIDAYLKEMSKYPGSATS--SFNEENLICSTLDLFLAGTETTSDMRWGLLFM-ALYPEIQEKVHAEIDSVIGQWQQPSMASRESLPYTNAVIHEVQRMGNILPLNVPREVTVDTTLAGYHLPKGTVVLTNLTALHKDPEEWATPDTFNPEHFL---ENGQFKK--KEAFIPFSIGKRACLGEQLAKSELFIFFTSLMQKFTFK 471          

Query:  247 GWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVF 1644
            G P++G I+   EP+   L K SK +G +F+  +G RD++ILS+  ++ K L + G NFSGR++  LI   T +SGI+F + + W+TQRSF LKVLRDFG GK +S ++V NEC  LL+++E   GK++    + P  T N+I+K +MN RFE ++     + K++ + I+  + I  L  M+P  D        ++ ++ + K       +    ID+H K  +  +EGED +D FL +Q++L ++ +   +F D QLIR  LELF+AGYETTSTTL WS L ++KH +IQ+KV+ EI++++G E+LP   DKK + YTQAVMDEI R+S+V PL++ HR   +  +DG +IPK+++IFPNL+ACH D ++WEKP  FYPEHFL  +++G LKYTPRDEL+ FSIGKRQCLGE LAR+EFFIF T I+Q+F+++   E++E+E+ +   G DG IR  + +D +F
Sbjct:   38 GLPILGIIHKIKEPMHNYLLKLSKKHGPIFRIKLGMRDVLILSNYDIIKKALVDDGQNFSGRWRMKLISLITHDSGIIFKDGQDWSTQRSFVLKVLRDFGLGKSKSVDLVQNECSFLLEELESLEGKIIDFSKIIPIYTANIISKFIMNKRFERENPKIARIEKMLSEEIKKKDIIQLLHIMFPKCDTSGLFCELIINFTSKWKEFLEIQNYFKEEIDEHLKTIDFNSEGEDLMDRFLIKQNQLKQQNIDVGSFNDWQLIRSSLELFYAGYETTSTTLCWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLALIHRTLNDANIDGYFIPKNTLIFPNLYACHFDRDIWEKPMIFYPEHFLTEDDNGNLKYTPRDELILFSIGKRQCLGESLARMEFFIFFTSILQRFRVKLVKELNEKEYEEALLGKDGIIRGSIVNDFIF 503          

Query:  142 FVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFE-SDSKDFTELTKLIEKAI----QNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFE 1647
            F+L    L I  Y   + F  +S    L       GWP++G I     P+   L + S+ +G +F+  +G RD+VIL + + + K L +    FSGR++  L+   T +SGI+F +   W+TQRSF LKVLRDFG GK  SQ+IV  EC+ LL +++   G+++    + P  T N+I+K +MN RF+ SD +      K IE AI    + ++ +  L  M+PI D    I+ F LW + + +      +  ++ I++HK   +  +EG+D ID FL EQ++L++      +FTD+QLI +  E+F AGYETTSTTL WSML ++++ +IQ+KVY+EI++++G E++P   DKK L YTQAVMDEILR+S+V PL I HR F +T VD  +IPK+S++F N +ACH D ++W KP EFYPEHFL    + +LKY+PR+EL+PF IGKRQC+GE LAR+E+FIF   I+Q++++ F   IS+  F +  RG +G IR     + +F+
Sbjct:    3 FILSIFGLFIIWYCFSRVFKRRSIPNGLKETPIEYGWPILGIIPKIKGPMQNYLLELSRKHGPIFRIRLGMRDVVILGNYQTIRKALVDDAQIFSGRWKMKLVSVVTHDSGIVFKDGPVWSTQRSFILKVLRDFGMGKSISQDIVQGECLFLLNELDSLQGEIIDFSKIIPIYTANIISKFIMNKRFDRSDPR-----IKFIEYAIFQTSKQSDIVQRLHLMFPIFDKSTIISKFNLWITSKLQLFSKVERVFHDEIEEHKTNLDYNSEGDDLIDRFLLEQNRLSQSTGIVESFTDKQLIFMTFEMFGAGYETTSTTLGWSMLFMSRYKDIQKKVYEEILNVIGEERMPTMNDKKSLNYTQAVMDEILRLSSVAPLGIFHRTFNDTSVDNYFIPKNSLVFANYYACHTDPDIWLKPVEFYPEHFLIKCENDELKYSPREELIPFGIGKRQCIGESLARMEYFIFFVSILQRYQVDFSENISDSLFEETLRGNEGIIRYSKIKNFIFK 504          

Query:  262 GNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLK--EQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRN-----KTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            GN+ +   P ++V + K+ + YG L  +T G R  VIL+S  ++ + L   E    FSGR  +  I + T   GI+  E E W   R FALKVLRDFGF +  ++E +  E   L + ++ E  ++V      P+A  NVI+ L+ N R  +  + FT+     ++ +Q NN    +   +P L ++P     LL   G +     +  ++T +F  + ID H++     +E  DF+D FL EQ +LN ++  +H+F D QL+R + ELF AG +TTS T+ W++L  A HPE Q+++  E+    G  +LP + DKK + +T A +DE+ R ST+ P S+ HR   +    G  I  + +I  NL+  H D  +W++P +F PE F  IN+SG+  Y   + LVPFSIGKR CLGE LAR E F+FL+GI Q +++    +   ++   I  G+ G + AP    ++F  R
Sbjct:   52 GNLFNLERPTFLVAHSKWRRQYGDLVSFTFGSRRFVILNSYAVIKEALTSPEWAEVFSGRINSPFILSMTHGKGIVSAEGELWREHRRFALKVLRDFGFARSGTEEAIHAELAELQQTLDAEPAELV------PRAIANVISVLLFNYRAGTQDEGFTDFMLASQENLQGNNIGRFIPTAFPGLYSIPGFMR-LLQLIGVDVFVFKRNIEVTHRFCRDQIDRHRRNLAEVSEPADFLDAFLLEQQRLNSKR-SDHSFDDFQLVRTLTELFIAGTDTTSNTIRWALLYAALHPECQDRIAAEVEAATGNSRLPVYRDKKAMHFTMAFIDEVQRYSTLAPFSVGHRCTRDIRFKGYDISSNDLIMVNLYGVHHDPELWDQPEQFRPERF--INSSGE--YETSEFLVPFSIGKRACLGESLARQELFLFLSGIFQAYRVELHKDCY-KDLKDIEVGSAGLVHAPGKHQIIFHRR 510          

Query:  262 GNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLK--EQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRN-----KTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            GN+ +   P ++V + K+ + YG L  +T G R  VIL+S  ++ + L   E    FSGR  +  I + T   GI+  E E W   R FALKVLRDFGF +  ++E +  E   L + ++ E  ++V      P+A  NVI+ L+ N R  +  + FT+     ++ +Q NN    +   +P L ++P     LL   G +     +  ++T +F  + ID H++     +E  DF+D FL EQ +LN ++  +H+F D QL+R + ELF AG +TTS T+ W++L  A HPE Q+++  E+    G  +LP + DKK + +T A +DE+ R ST+ P S+ HR   +    G  I  + +I  NL+  H D  +W++P +F PE F  IN+SG+  Y   + LVPFSIGKR CLGE LAR E F+FL+GI Q +++    +   ++   I  G+ G + AP    ++F  R
Sbjct:   83 GNLFNLERPTFLVAHSKWRRQYGDLVSFTFGSRRFVILNSYAVIKEALTSPEWAEVFSGRINSPFILSMTHGKGIVSAEGELWREHRRFALKVLRDFGFARSGTEEAIHAELAELQQTLDAEPAELV------PRAIANVISVLLFNYRAGTQDEGFTDFMLASQENLQGNNIGRFIPTAFPGLYSIPGFMR-LLQLIGVDVFVFKRNIEVTHRFCRDQIDRHRRNLAEVSEPADFLDAFLLEQQRLNSKR-SDHSFDDFQLVRTLTELFIAGTDTTSNTIRWALLYAALHPECQDRIAAEVEAATGNSRLPVYRDKKAMHFTMAFIDEVQRYSTLAPFSVGHRCTRDIRFKGYDISSNDLIMVNLYGVHHDPELWDQPEQFRPERF--INSSGE--YETSEFLVPFSIGKRACLGESLARQELFLFLSGIFQAYRVELHKDCY-KDLKDIEVGSAGLVHAPGKHQIIFHRR 541          

Query:  262 GNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLK--EQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRN-----KTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            GN+ +   P ++V + K+ + YG L  +T G R  VIL+S  ++ + L   E    FSGR  +  I + T   GI+  E E W   R FALKVLRDFGF +  ++E +  E   L + ++ E  ++V      P+A  NVI+ L+ N R  +  + FT+     ++ +Q NN    +   +P L ++P     LL   G +     +  ++T +F  + ID H++     +E  DF+D FL EQ +LN ++  +H+F D QL+R + ELF AG +TTS T+ W++L  A HPE Q+++  E+    G  +LP + DKK + +T A +DE+ R ST+ P S+ HR   +    G  I  + +I  NL+  H D  +W++P +F PE F  IN+SG+  Y   + LVPFSIGKR CLGE LAR E F+FL+GI Q +++    +   ++   I  G+ G + AP    ++F  R
Sbjct:   52 GNLFNLERPTFLVAHSKWRRQYGDLVSFTFGSRRFVILNSYAVIKEALTSPEWAEVFSGRINSPFILSMTHGKGIVSAEGELWREHRRFALKVLRDFGFARSGTEEAIHAELAELQQTLDAEPDELV------PRAIANVISVLLFNYRAGTQDEGFTDFMLASQENLQGNNIGRFIPTAFPGLYSIPGFMR-LLQLIGVDVFVFKRNIEVTHRFCRDQIDRHRRNLAEVSEPADFLDAFLLEQQRLNSKR-SDHSFDDFQLVRTLTELFIAGTDTTSNTIRWALLYAALHPECQDRIAAEVEAATGNSRLPVYRDKKAMHFTMAFIDEVQRYSTLAPFSVGHRCTRDIRFKGYDISSNDLIMVNLYGVHHDPELWDQPEQFRPERF--INSSGE--YETSEFLVPFSIGKRACLGESLARQELFLFLSGIFQAYRVELHKDCY-KDLKDIEVGSAGLVHAPGKHQIIFHRR 510          

Query:  220 NLNLLQGPTGWPLIGNINSFNEPLWMV-LYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGR-FQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILT-LFQMYP-ILDNMPFIAPFLLWWSGRNKTA----KITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEF 1581
            +LN   GP   P +GNI     P   + L K  K Y ++F   +G++ +++L+  KM+ + L  Q +NF  R +     +  + N G+  +    W  QR FAL  LR+FG GK+  +  +  E   LL +++   G+      LF  A  N+I +LV   R++    DF ++ K   +AI     I   L++ +P I+ ++P          GR+       +  S+FI   +D HK   +  N   D++D FL E+   ++       F+D+ L+R  L+LF AG ETT+T+L W+++ LAK+PEIQ+KV +EI  ++G  + P  ADK  + YT+AV+ EILR   +VPLS      ++T + G  IPK + I P L +   DE+ WE P  F P+HFL+       K+  RD  + FS GKR CLGE LAR+E F+F T + QKF+    +E+  EE 
Sbjct:   34 SLNFPSGPLALPFLGNILDIASPQPHIYLTKLGKAYNNIFSMRIGQQKMILLTGYKMVKEALVNQTDNFVDRPYSPLAERIYSGNGGLFTSNGNLWKKQRRFALSTLRNFGLGKKTMELAICEESHFLLDEMDRHKGQAFDPSGLFNNAVSNIICQLVFGQRYDYADYDFQQMLKYTSEAIHLEGSIWGRLYESFPNIMKHLP----------GRHNVIFSNYEHISEFIKKNLDKHKANLDPSNP-RDYMDSFLIEKENSHDPA---DGFSDKNLVRCTLDLFLAGTETTTTSLGWALIYLAKNPEIQDKVQEEIDRVIGQSRQPGMADKPNMPYTEAVIHEILRRGDIVPLSGPRVAAKDTTLGGYAIPKGTTIMPILHSVLFDEDEWETPNSFNPQHFLDKEG----KFVRRDAFLAFSAGKRVCLGEQLARMELFLFFTCLFQKFRF---SEVEGEEL 474          

Query:  133 MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTE-LTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKI 1590
            + + VL++I + +   FIK         +  N   GP   P+ GN+   N   PL     + ++ YG+++    G R  VIL+  K + + L  +  +FSGR QN L+   T   GI F +   +W  QR FAL  LR+FG GKQ  ++ +  E   L+  +++  G  ++  +LF +A  N+I  ++  +R+E   +   + +T  +E     N F   ++  +P L  +P   PF    +  +    I +    N++  HK    +  E ++F+D +L E  K  E      +FT+ QL+R +++L  AG +TTS TL  + L L  HP+IQEK  +EI + L  +   +F D+  + YTQAV+ E LR++  VPLS+ H    +TE+ G  IPKD+++FPNL +   +E  W+ P EF P++FL  N+ GQ +    +  +PFS G R CLGEGLAR+E F+ L  ++++F+  +  +  E +F  +
Sbjct:    2 LGSLVLVWIFICLLFLFIK-------IQRPKNFPPGPRPVPIFGNVFQLNISNPL-KDFERIAERYGNVYSLYFGGRPAVILTGFKAVKEALVTKAADFSGRPQNVLVSHITEGKGIAFVDYGPYWKEQRRFALMSLRNFGLGKQSMEDRILGEIQHLVVCMDKSVGGFMNPDTLFHEAASNIIYLVLFGIRYEYGDETLKQYVTSFVESTKIANGFWGMIYDTFPALRGLPL--PFRKAITHFDIVKNINA----NMVSKHKPS-RVPGEPKNFVDCYLDELEKQKEND--GSSFTEGQLVRTIMDLHAAGTDTTSNTLRTAFLYLITHPDIQEKCQREIDEALKGKAHASFEDRHDMPYTQAVIHESLRIAKTVPLSVPHCTTRDTELMGYSIPKDTLVFPNLASVLSEEGQWKFPHEFNPDNFL--NDHGQFEKP--EAFLPFSAGPRVCLGEGLARMELFLILVTLLRRFQFFWPEDAGEPDFTPV 470          

Query:  133 MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTE-LTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKI 1590
            + + VL++I + +   FIK         +  N   GP   P+ GN+   N   PL     + ++ YG+++    G R  VIL+  K + + L  +  +FSGR QN L+   T   GI F +   +W  QR FAL  LR+FG GKQ  ++ +  E   L+  +++  G  ++  +LF +A  N+I  ++  +R+E   +   + +T  +E     N F   ++  +P L  +P   PF    +  +    I +    N++  HK    +  E ++F+D +L E  K  E      +FT+ QL+R +++L  AG +TTS TL  + L L  HP+IQEK  +EI + L  +   +F D+  + YTQAV+ E LR++  VPLS+ H    +TE+ G  IPKD+++FPNL +   +E  W+ P EF P++FL  N+ GQ +    +  +PFS G R CLGEGLAR+E F+ L  +++ F+  +  +  E +F  +
Sbjct:    2 LGSLVLVWIFICLLFLFIK-------IQRPKNFPPGPRPVPIFGNVFQLNISNPL-KDFERIAERYGNVYSLYFGGRPAVILTGFKAVKEALVTKAADFSGRPQNVLVSHITEGKGIAFVDYGPYWKEQRRFALMSLRNFGLGKQSMEDRILGEIQHLVVCMDKSVGGFMNPDTLFHEAASNIIYLVLFGIRYEYGDETLKQYVTSFVESTKIANGFWGMIYDTFPALRGLPL--PFRKAITHFDIVKNINA----NMVSKHKPS-RVPGEPKNFVDCYLDELEKQKEND--GSSFTEGQLVRTIMDLHAAGTDTTSNTLRTAFLYLITHPDIQEKCQREIDEALKGKAHASFEDRHDMPYTQAVIHESLRIAKTVPLSVPHCTTRDTELMGYSIPKDTLVFPNLASVLSEEGQWKFPHEFNPDNFL--NDHGQFEKP--EAFLPFSAGPRVCLGEGLARMELFLILVTLLRCFQFFWPEDAGEPDFTPV 470          

Query:  133 MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTE-LTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKI 1590
            + + VL++I + +   FIK         +  N   GP   P+ GN+   N   PL     + ++ YG+++    G R  VIL+  K + + L  +  +FSGR QN L+   T   GI F +   +W  QR FAL  LR+FG GKQ  ++ +  E   L+  +++  G  ++  +LF +A  N+I  ++  +R+E   +   + +T  +E     N F   ++  +P L  +P   PF    +  +    I +    N++  HK    +  E ++F+D +L E  K  E      +FT+ QL+R +++L  AG +TTS TL  + L L  HP+IQEK  +EI + L  +   +F D+  + YTQAV+ E LR++  VPLS+ H    +TE+ G  IPKD+++FPNL +   +E  W+ P EF P +FL  N+ GQ +    +  +PFS G R CLGEGLAR+E F+ L  ++++F+  +  +  E +F  +
Sbjct:    2 LGSLVLVWIFICLLFLFIK-------IQRPKNFPPGPRPVPIFGNVFQLNISNPL-KDFERIAERYGNVYSLYFGGRPAVILTGFKAVKEALVTKAADFSGRPQNVLVSHITEGKGIAFVDYGPYWKEQRRFALMSLRNFGLGKQSMEDRILGEIQHLVVCMDKSVGGFMNPDTLFHEAASNIIYLVLFGIRYEYGDETLKQYVTSFVESTKIANGFWGMIYDTFPALRGLPL--PFRKAITHFDIVKNINA----NMVSKHKPS-RVPGEPKNFVDCYLDELEKQKEND--GSSFTEGQLVRTIMDLHAAGTDTTSNTLRTAFLYLITHPDIQEKCQREIDEALKGKAHASFEDRHDMPYTQAVIHESLRIAKTVPLSVPHCTTRDTELMGYSIPKDTLVFPNLASVLSEEGQWKFPHEFNPVNFL--NDQGQFEKP--EAFLPFSAGPRVCLGEGLARMELFLILVTLLRRFQFFWPEDAGEPDFTPV 470          

Query:  181 FIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTE-LTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKI 1590
            FI   FF     +  N   GP   P+ GN+   N   PL     K+++ YG+++    G +  VIL+  K + + L  +  +FSGR QN L+   +   GI+F +   +W  QR FAL  LR+FG GKQ  ++ +  E   L+  +++  G  ++  +LF +A  N+I  ++  +R+E   +   + +T  +E     N F   ++  +P L  +P      L +    K + +  K   N+++ HK    +  E ++F+D FL E  K   +     +F+++QL+  V++L  AG +TTS TL  ++L L  +P+IQEK  +EI + L  +   +F D+  + YTQAV+ E LR++  VPLS+ H    +TE+ G  IPKD+++FPNL +   +E  W+ P EF P +FL  N+ GQ +    +  +PFS G R CLGEGLAR+E F+ L  ++++F+  +  +  E +F  +
Sbjct:   11 FICLLFFFIRIQRPKNFPPGPRPVPIFGNLFQVNISNPL-KDFEKFAERYGNVYSVYFGGKPAVILTGFKAVKEALVTKSADFSGRPQNVLVSHVSEGKGIIFVDYGHFWKEQRRFALMSLRNFGLGKQSMEDRILGEIQHLVARMDKSVGGFMNPDTLFHEAASNIIFLVLFGIRYEYGDETLKQYVTSFVETTKIANGFWGMIYDTFPALRWLP------LPYRKALKHSALVRKINANLVNKHKPT-RVPKEPKNFVDCFLDEMDKAPND---GSSFSEKQLVSSVMDLHAAGTDTTSNTLRTALLYLITNPDIQEKCQREIDEALKGKAHASFEDRHDMPYTQAVIHESLRIAKTVPLSVPHCTTRDTELMGFSIPKDTLVFPNLASVLSEEGQWKFPHEFNPVNFL--NDQGQFEKP--EAFLPFSAGPRVCLGEGLARMELFLILVTLLRRFQFFWPEDAGEPDFTPV 469          

Query:  142 FVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFIL-TLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDD-HKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            F +IF+ L   L  +K      +  + L+   GP   P +GN++ F +P  + L + +K YG +    +G+  +V +S  + + + L  QG+ F+ R      K      GI+F    ++W   R F L  LR+FG GK   ++ +  E   L++  +++ G           A  N+I  +V   R+E   K F +   L+E  +Q  + +L TL  ++P L  M F  P  + +    K+     +FI +II + H  R  I+      ID +L +   L +E   N +F++Q LI + L+LF AG ETTSTTL W +L +  HPEIQ + ++EI  ++G+++LP   D+  L Y  AV+ EI R S +VP    H    + +     IPK +II  N+ +   DEN W+ P+EF PE+FL+ +     K+   D  +PFS G R CLGE LA++E F+F   ++Q F+  + + +S      I + T    +AP S  +   LR
Sbjct:   30 FCIIFLVLRAILQEVK------ATKRPLDFPPGPKVIPFLGNVSLFKKP-DVALDEVTKQYGEVCSVMVGKISMVFVSGYQAVKEVLVHQGHEFADRPNTPFNKKVNGGLGIIFAPYGKYWMQHRRFTLSTLRNFGLGKSSIEQTIQAEVGFLIEAFKQK-GSAFDPHYDLNSAVGNIICSMVKGKRYEYSDKQFQDFLHLVENNLQLQSGLLGTLCNIFPFL--MDFPGPQQIIFKSMAKS----KQFIRDIISERHATRDPIKPMC--LIDAYLSQ---LEKEDNPNSSFSEQSLIMLALDLFIAGAETTSTTLRWGLLYMMMHPEIQAQCHEEIDKIVGSDRLPCMEDRHSLPYLDAVIHEIQRFSNIVPFGAPHATTADVKFRQYLIPKGTIIMVNMKSVLSDENHWKTPYEFSPENFLDEDG----KFVKPDAFLPFSAGPRVCLGENLAKMELFLFFASLLQHFEFYWPDLVSAPTLGYILQIT----KAPKSYKLGLHLR 509          

Query:  238 GPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRN-SGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFS-IGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            GP G PL+GN+   + + L   L K S+ YG ++  ++G+  +V+L  ++++ + L  Q   F  R +  + K    N  G+L +    W  +R F L +LR+FG G +  +E ++ E   L++ IE +  K   A S   K+  NVI  +    R++ ++K F +L  +I + ++ + N    +F  +P+L   P   P        NK   + + FI   I++H     I+ E  D++D F+ +  ++ +    +  F+D  LI     LF AG ETTS TL W +LL+  +P++QE+V +EI  ++G+ + P  AD+ C+ YT A + EI R + ++P++  H    +T++ G ++PK + +   + +  R++++WE P +F P HFL+I+ +    +  R++ + FS +G R CLG+ LAR+E F+F T ++Q+F
Sbjct:   43 GPRGLPLVGNLFQLDLKALPASLDKLSETYGPIYSVSLGQTRVVVLVGNEIIKEALVTQAEMFIDRPEIPVFKKSLGNYEGLLLSHGWQWRARRRFTLMMLRNFGMGTKSIEEKIAEEAEFLVRAIENKQEKPFDAHSEINKSAANVICSITFGDRYDWNNKTFVKLMDIITENVELSGNDWSQIFNSFPVLKYFP--GPH----QRINKNKVVLNAFIQARIEEHDMA-RIQGEPRDYLDAFIDK--RIEDSMNPDTAFSDIALINTTANLFVAGSETTSATLKWGILLMLTYPKVQEQVQEEIDRVVGSNRRPACADRACMPYTNATVHEIQRYANILPMAFPHATTCDTKLRGYFLPKGTQVIALIHSALREKSLWEAPEQFNPGHFLDIDGN----FYNRNDFMAFSAVGPRICLGKNLARMEVFLFFTALLQRF 468          

Query:  265 NINSF--NEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGI-LFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYP--ILDNMPFIAPFLLWWSGR-NKTAKITSKF---INNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFA 1584
            NI +F  N P  + + + +K YG +    +G   +V++S  + + + L  +G+ F+ R    +    T+N GI L    + W  QR FAL  LR+FGFGK    + +S E   L++  ++E        +L   A  N+I  L+   R++ D++ F +LT L+E  +Q         Q  P  IL N   + PFLL   G   K   I SK    +N+I+ +H+   +  N   D ID +L +  K  E+   N +FT Q LI++++ELF  G ETTS TL W +L +  +P+IQ + + EI  ++G+E+ P   D++ L Y  AV+ EI R   V+PL + H   ++ + +    PK + +  NL +   D+  W+ P +F P+HFL  +  GQ   +  D  +PFS G R CLGE LA++E F+F T ++Q F+  + N +S    A
Sbjct:   50 NITAFICNNP-HIAMQELAKKYGEVCTIMLGSTPVVLVSGYEAVKEVLVNRGHEFADRPITPIFTKLTQNIGIALAPYGDPWKQQRRFALSTLRNFGFGKATIADKISIEAKYLIETFKQETSAFDPHLNL-NNALGNIICCLLNRNRYDYDNEQFQKLTHLLEYLVQ--------LQAEPLVILCN---VFPFLLKLPGPWQKVFHIHSKLQCLLNDIVSEHRATKDQHNP-RDLIDSYLAQIDK--EKDNPNSSFTHQSLIQILIELFIGGLETTSNTLRWGLLFMMMNPDIQARCHGEIDRVVGSERPPCMTDRRSLPYLDAVIHEIQRFGNVLPLGVLHATSKDVQFNDYLFPKGTHVMVNLMSALHDDIHWKTPNKFNPDHFL--DKDGQCIQS--DAFLPFSAGPRVCLGESLAKMEIFLFFTSLLQHFEFYWPNSVSPPTLA 478          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGI-LFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGT 1602
             ++F+T+  AL  +       S    +    GP   PL+GNI +F+ +   + + + +K YG +    +G   +V++S  + + + L  +G+ F+ R    L    T N GI L    + W  QR FAL  LR+FGFGK    + +S E   L++  ++E  +    + +   A  N+I  L+  +R++ +++ F +LT L+E  +Q     ++ L  ++P L  +P   P   W    +   K+    + +I+ +H+   +  N   D ID +L   H   E+   N +FTDQ LI +++ELF  G ETTS TL W +L +  +P+IQ + ++EI  ++G+++ P   D++ L Y  AV+ EI R   ++P  + H   ++ + +    PK + +  NL +   D+  W+ P +F P++FL  +  GQ   +  D  +PF  G   C GE LA++E F+F T ++Q F+  + N  S    A   R T
Sbjct:   12 CMVFLTVRAALQVVG------STICPVGFSPGPKPLPLLGNITAFSCKNPHIGMQELAKKYGEVCTIMLGSTPVVLVSGYQAVKEVLVNRGHEFADRPITPLFTKLTHNIGIALAPYGDTWKQQRGFALSTLRNFGFGKATITDKISIEARYLIETFKQETSEF-DPKFILNSAVGNIICSLLNGIRYDYNNEQFQKLTHLLEHLVQLQAEPLVILCNVFPFLIKLP--GP---WQKVFHIHTKLQC-LLKDIVSEHRATKDQHNP-RDLIDSYLA--HIDKEKDNPNRSFTDQTLILLLIELFIGGMETTSNTLCWGLLFMMMNPDIQARCHEEIDKVVGSQRPPCMKDRRSLPYLDAVIHEIQRFGNILPFGVLHPTSKDVQFNEYVFPKGTHVMVNLMSAFYDDIHWKTPHKFNPDNFL--DKDGQCIKS--DAFLPFPAGPCVCFGESLAKMELFLFFTSLLQHFEFYWPNSASPPTLAAKFRTT 480          

Query:  301 LYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSG---ILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQN-NNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLK-EQHKLNEEK--VKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIR 1551
            L + ++ YG+++   +G  DIV+L++ + + + L ++  +F+GR Q +    +    G    L      W  QR  AL  L     G  R++EIV  E   L++D+ +  G+     +       NVI  +    +++    +F ++   ++  ++   +  +     +P+L   P  A     W       +   + +   I  HK + +      D  D  LK  +H  NEE+   +    T++++   +++ F AG ETT+T + W++  L  HPE+Q+++Y+E+   L     P+ AD+  L Y  A + EILR+  V PL+I HR   ++ V G +I K S +  NL+A HRD   W+ P  F P  FL  +     +  P   L+PF  GKR CLGE LA+ E F+FL  ++++ +++
Sbjct:   68 LTQLARTYGAVYCLRVGGEDIVVLNNVESIKEMLIKKSADFAGRPQTY-AGGKITGGGKDIALGDYSAVWRRQRRAALSALH--CVGTARTEEIVQGEAQRLVEDLTQYIGRPTDIHTDISMRVCNVICSVAFGTKYDKHDTEFLDIHCCLDSLVRLWGSPAIRALDCFPVLRLFPNPA-----WRDLMAAVRKRDEVVWRQILLHKAKPSSSPS-SDMTDFLLKFTRHSRNEEESEARGGILTEERVHLSIMDTFIAGVETTATLIEWALAYLVLHPEVQDQIYEEMEQKLQPGLGPSLADRDKLLYLDATIKEILRLCPVAPLAIPHRALRDSSVGGFFICKGSTVIANLWAAHRDHAHWDNPSVFQPGRFLGESLE---RRNPASLLLPFGAGKRVCLGESLAKAEIFLFLGHVLRRLRLQ 479          

Query:  802 LDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKL-----NEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDL----LGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYI-PKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFL 1521
            L N P I P+   W G+ KTA +  K   N     K       +    +D + K  H       ++ ++ +  FT++++   V    FA  + +S+   W   ++A  P++  K+ +E + +    + TE   +  +K  ++YT  V+ E LR    V L + + V +N  V   Y  PK +++ P L+    D  V+E P EF PE ++  + + + K   ++ LV F  G   CLG+    I F   L
Sbjct:  249 LVNFPIIIPYTKTWYGK-KTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEK--MKYTNMVIKETLRYRPPV-LMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAK---KNWLV-FGCGPHVCLGQTYVMITFAALL 490          

Query:  652 PKATVNVIAKLVMN--MRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLL-GTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYP-EHFLNI---NNSGQLKYTPRDEL---------------VPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRF 1554
            P+ T+   ++ ++   MR + D+ DF  L   ++K     NF+           N+P     L  +  R+   K  S    ++I + +K  +I++   D ID  +K     N         TDQ++  +++ +   G  T++ T +W +L LA+ P++Q+++Y+E + +L G +K   +   + +      + E LR+    PL   H +F     D +++P  S + P  +             E++P  H  NI   N      Y+  +E+               +PF  G+ +C+GE  A  +  + ++  I+  K  +
Sbjct:  201 PEMTIFTASRSLLGKEMRAKLDT-DFAYLYSDLDKGFTPINFVFP---------NLP-----LEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDR--DLIDSLMK-----NSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHH--PL---HSLFRKVMKD-MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHY 495          

Query:  226 NLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYG-SLFKYTMGRRDIVILSSSKMLFKTL-KEQGNNFSGRFQNFLIKARTRN--SGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEK----AIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNK-TAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTF-TDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEE 1578
            N   GP  +P +GN       L   L    K YG  +F+  +  +  VI+ + K+  + L K+ G + + R   ++I A +RN  S I       W  QR      LR +G G +  + ++  E   L        G  V  +     + +NVI  LV   R+  D  +FT++    E     A   N  I            MP++  F L    + K T     + I   I +H++ +  E E  D  D  LK      +E     +  T+  L+  + ++F AG+ETT+T L W  L +A +PE+Q +++QE+ D++   + P  AD+K L Y +A + E+LR+S V PL I  +  +   + G  IP+++ ++ NL+A H DE  W  P++F P  FL   NS    Y+    ++PF  G R C+GE LA++E F+F++ ++ +FK+  + +  + E
Sbjct:   27 NAPPGPPLYPFVGNFPQIGPVLHKSLTSLGKQYGRGVFQVQLLGKRFVIIDNIKLARQVLLKKNGRDVADRTSAYVIDAISRNGCSVIFGKYSPTWKLQRRVVHSALRMYGSGVRILEALILQEVDNLCDIFANSQGAPVDTKLPLTLSVMNVICALVFGKRYGLDDAEFTDIVATTESMAKLASPENPLIY-----------MPWLRFFPLQVVKKMKETVTARDRLIQRKITEHRETYK-EGEIRDLTDALLKSLEDAKQEDNNAMSLLTEDHLLIAINDVFMAGFETTTTALRWIFLYVAAYPEVQARIHQELDDVISFGRDPLIADRKSLPYLEATILEVLRISPVFPL-IRRKARKQLNIGGYCIPEETFVYVNLWAIHHDEAEWVDPYKFRPSRFLEGTNSAS-AYS----MLPFGAGVRVCVGESLAKMELFLFVSRLLHRFKLNLKGQCPDME 469          

Query:  238 GPTGWPLIGNINSFNEP-LWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTL-KEQGNNFSGRFQNFLIKARTRNSGIL----FTEKEWWATQRSFALKVLRDF--GFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGR-NKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKL-NEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGT 1602
            GPT  PLIGN+ S     +   L   +K +G +    +    IV+++S  +  + L  +  N+F+GR + F  +  ++    +    ++    W  +R      LR +    G     + ++ E   L   +  + G  V ++  F    +N+I   +    F+ +  +F+E  +L+ K +       TL     ILD  PF+  F L  S    + A++  K + NI+  HK+ FN EN   D  D FLK +  +  E+K      TD+++  ++++++ AG ETT T+L W +  L  + E+Q +V   I D++G ++ P  +D++ L Y +A++ E+LR+S  +PL + H+   +T +DG  IPK + +  NL+A H D   W +P +F P+ F  IN  G+ +       +PF  G+R CLGE LA++E F+ +T ++Q+F           E   I+  T
Sbjct:    4 GPTPLPLIGNLLSIKSSNIHFELANLAKTHGDIMMIELFGMKIVVVTSGPLAREVLMGKHINDFAGRPKRFTFEYMSKGYKDIALNDYSPGLVW--KRKIVHSGLRKYFPSLG-----DTIAKELAKLEDKLNSDVGVPVDSKDEFFLLVLNIICSFLSGKAFDKEDPEFSETLELVTKTVD------TLSMSASILDAFPFLIHFPLQASKNFKRIAELRDKLMGNILTFHKETFN-ENHIRDLTDAFLKAKLDIEREDKKAAGEVTDEEVALMMMDVYLAGLETTVTSLRWIIAYLMNNQEVQSRVQSRIDDVIG-DRRPLMSDRQGLPYMEALVAEVLRLSPPIPLGLPHKSILDTTIDGYTIPKGTTVLFNLWAIHHDPREWPEPDKFDPDRF--INEDGKFEVPGDRNFLPFMAGRRVCLGESLAKMELFLIMTRLLQQFTFEPPTGHPPPELTGISAAT 451          

Query:  238 GPTGWPLIGNINSFNEP-LWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTL-KEQGNNFSGRFQNFLIKARTRNSGIL----FTEKEWWATQRSFALKVLRDF--GFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGR-NKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKL-NEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKF 1542
            GPT  PLIGN+ S     +   L   +K +G +    +    IV+++S  +  + L  +  N+F+GR + F  +  ++    +    ++    W  +R      LR +    G   ++E+   E       +  + G  V ++  F    +N+I   +    F+ +  +F+E  + +   +       T+     ILD  PF+  F L  S    + A++  K + NI+  HK+ FN EN   D  D FLK +  +  E+K      TD+++  ++++++ AG ETT T+L W +  L  + E+Q +V   I D++G ++ P  +D++ L Y +A++ E+LR+S  +PL + H+   +T +DG  IPK + +  NL+A H D   W +P +F P+ F  IN  G+ +       +PF  G+R CLGE LA++E F+ +T ++Q+F
Sbjct:    4 GPTPLPLIGNLLSIKSSNIHFELANLAKTHGDIMMIELFGMKIVVVTSGPLAREVLMGKHINDFAGRPKRFTFEYMSKGYKDIALNDYSPGLVW--KRKIVHSGLRKYFPSLGDTIAKELAKLE-----DKLNSDVGVPVDSKDEFFLLVLNIICSFLTGKAFDKEDPEFSETLEFVTMTVD------TISMSASILDAFPFLIHFPLQASKNFKRIAELRDKLMGNILTFHKETFN-ENHIRDLTDAFLKAKLDIEREDKKAAEEVTDEEVALMMMDVYLAGLETTVTSLRWIIAYLMNNQEVQSRVQSRIDDVIG-DRRPLMSDRQGLPYMEALVAEVLRLSPPIPLGLPHKSILDTTIDGYTIPKGTTVLFNLWAIHHDPREWPEPDKFDPDRF--INEDGKFEVPGDRNFLPFMAGRRVCLGESLAKMELFLIMTRLLQQF 431          

Query:  301 LYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRN-SGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFK 1545
            L + +K YG +F+  +G   IV+++S +   + L  + N+F+GR   +     +RN + I F +    W  QR  A   LR FG G +  +E ++ E   L+K +    G+  + +     A +N+I   V   R++ D  +F  +    E+ +Q      +L   +P L ++P      +  + +N+   +  K+  +++              D  D  L   +K ++E+      T+  +I  + ++F AG ETT+T++ WS++ L ++P++QE+++Q+I +++G ++ P  +D++ L   +A + E+LR S++VPL   H    +T + G  +PKD+I+  N++  H D   W  P EF P  FL  ++ G+         +PFS G+R CL E L +++ F+F++ ++ KF+
Sbjct:   12 LTELAKSYGEVFRLKVGSHRIVVVNSIEAAREALVRRANDFAGRPMLYTASLISRNGTDIAFGDFGPLWKQQRKIAHSALRMFGSGLKPLEEKITVEADELIKRLSLVEGRAHNPKDDVNLAVLNIICSFVFGSRYDMDDPEFHTVVDYTEQFVQGFR-AASLVDYFPWLRHLPNKGLRQIKEACQNRDVVLQKKYQEHLVTYEHGVI------RDLTDALLS-ANKASQEESAYLPMTEDHIIMTMNDIFSAGLETTATSILWSLVYLIRNPKVQEQLHQQIDEVVGRDRAPELSDRENLPLIEATIAEVLRSSSLVPLLFPHSTTTDTHLRGYEVPKDTIVLFNVWNMHHDPQRWSNPDEFDPTRFL--DDKGKFICPATLSYLPFSAGRRVCLAESLGKMQLFLFISRLLHKFR 418          

Query:  259 IGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGR--FQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ---NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEE--KVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFK 1545
            IGN+N  ++ + +   +  K YG +++  +G +  ++LS   +  + L  Q  NF+GR      L  A  R  G+   +  E W   R      ++ +G  + R Q+++ +E + L   +E   GK          A  NVI   +   R++ D  +F  + ++ +K  +     N +  +F       ++  I PF        +  +   + +     +H K F+ EN   D+ D  LK +    +E    K H      ++  +  LF AG ETTSTTL W+++ L  +P++QE++++EI D++G +  P  + +K L   +A   E LR++ + PL+I H+  E + + G  IP+ + +F NL++ H D  VW+ PF F  + FL  +  G+ K       +PF  G R CLGE LAR E F+FL+ ++Q+F+
Sbjct:   37 IGNLNLLSKQMHLSFTELEKTYGKVYRLYLGHKLAIVLSGDAIK-EALVRQPRNFAGRPVLNPQLKSALNRGPGLTVMDYGETWKLFRKLGHSTIKVYG--ENRLQDVIKDEVLELCNRLESSAGKPFDITQQSGIAVTNVICTKLFGTRYQIDDPEFLRVYEIHDKLSRIGFGGNLVTNIFP------SLASILPFSEKQRDLIQIGQERYEILERKYQEHVKTFDPENI-RDYTDALLKAKQDAEQEDKSSKEHLQESTIIMAGLATLFIAGSETTSTTLGWAVIYLLHNPDVQERLHKEIDDVIGRDAFPQLSKRKELPVLEAFTAETLRLANLAPLAIPHKARERSTLQGFEIPEGTTVFANLWSLHHDPTVWKDPFTFNLDRFL--DEEGKFKAPVGGTFLPFGAGPRVCLGEVLARSELFLFLSRMLQRFE 461          

Query:  217 KNLNLLQGPTGWPLIGNINSFNEPLWMVLY-KYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGR-FQNFLIKARTRNS-GILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILT-LFQMYP-ILDNMPFIAPFLLWWSGRNK---TAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            K  N   GP G P +GN  + +     + + K ++ YG++F   +G +  V +S  KM+ + L  Q  NF  R F     +    NS G+ F+  E W  QR FAL  LR FG GK   ++ +  E   L + IE E G   S   LF  A  N+I +LVM  RF+ D  +F  + K I +A+Q    I   L++ +P ++ ++P            NK     KI   F+   I  HK+  +  N   D+ID F+ E  K     +    F D  L    L+LF AG ETTSTTL W+++ L KHP++Q KV QEI  ++G  +LP+ AD+  L YT AV+ EI R+  +VPL+      ++T + G +IPK + + P L +   D+  WE P  F PEHFL+ +     K+  ++  +PFS GKR CLGEGLAR+E F+FL G++QKF       +        T G  G  R P    V  ++R
Sbjct:   33 KPANFPPGPLGLPFVGNFLTIDGKHPHIYFSKMAESYGNVFSVRLGSQATVFVSGYKMVKEALVTQAENFVDRPFSEIGGRFYEGNSNGLFFSNGEKWKKQRRFALSTLRTFGLGKNTMEQSICEEIRHLQQQIENEKGGPFSPAGLFNNAVSNIICQLVMGKRFDYDDNNFQVMMKYISEAVQLEGSIWGILYESFPGLMKHLP---------GSHNKIFRNYKIVQDFLAQEIKIHKQDLDPNNP-RDYIDSFIIEMEKHQNSDLG---FNDANLAFCSLDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRLPSMADRPNLPYTDAVVHEIQRIGNIVPLNGLRVAAKDTTLGGYFIPKGTALMPMLTSVLFDKTEWETPDTFNPEHFLDADG----KFVKKEAFLPFSAGKRVCLGEGLARMELFLFLVGLLQKFSFSVPEGVELS-----TEGITGTTRVPHPYKVYAKVR 497          

Query:  148 LIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN-EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQ-NNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITS--KFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRG 1599
            L+ I   + LYFI +F FN  + ++     GP   P+IGN+   + +  +  L ++SK YG +F    G   +V+L+  K +   L      F  R    +I+   +  G+L++  + W   R FAL  LRDFG GK+  ++ ++ EC  LL+  ++  G           A  N+I  +V   RFE D   FT +     + IQ + +  L  + M P L           W + R +  +  +  +  N  I  H K          F+D FL +   L +  V N  F D+ L+  V+ LF AG ETTSTTL W +LL+AK+P+IQ++V  E+  ++G +++   +D+K L +T AV+ EI R++++VP ++ H+  ++    G +I K + +FP L +   D N WEKP  FYP HFL+ +     K+  R+  +PFS G+R CLGE LAR+E F+F T ++Q F       +S+EE +    G
Sbjct:   15 LVGILAVLVLYFISQFIFN--SEQHGQEPPGPRPLPIIGNLMQIDLKRPYKTLEEFSKTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHDEEFGERAIPPIIQELNKGLGVLWSNGDIWRDIRRFALTNLRDFGMGKKACEDKITEECQYLLEVFKKFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPTLQAYNMVPWL---------FKWVASRREVHECAAANRKQNQSIFSHLKETLNPQMCRGFVDAFLVKGQTLEKSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIG-DRMVQVSDRKNLPFTDAVIHEIQRLASIVPTALPHKTSKDVTFQGYFIKKGTTVFPLLTSVLHDANEWEKPHTFYPAHFLDKDG----KFVKREAFIPFSAGRRICLGESLARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCG 486          

Query:  142 FVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFN--EPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFIN---NIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGT 1602
            FV IF+ L +  +FI    F     +  N   GP   P++GN+   N   PL +   K  + YG+++ + +G R  V+++  + + + +  +  +FSGR Q+  +   T+  G++  +    W   R FAL  LR+FG GK   +E +  E    +  +EE  GK +S + +F  A  N+I K++ N R++ +    +E+ +   + +Q  N    +  MY   D  P+I  F L +   NK  +    F+N    ++++HK    +  E  DF+D +L E  K  ++      F++QQL+R+  +L+ AG +TTS T+    L L  +P IQEK  +EI  +L  +   +F D+  + Y QAV+ E+ R + +VPLS+ H   +++E+ G  IPK ++I  N+ +  R+E  W+ P EF PE+FLN     Q ++   +  +PFS G R CLGEGLAR+E FI +  +++KFK  +  +  + + + +   T
Sbjct:    2 FVSIFL-LWLCFFFI---LFQFKLWRPKNFPPGPLSLPVLGNLLHLNLKNPL-VDFEKMKESYGNVYSFFIGSRPAVVVNGLQAMKEAIMIKATDFSGRPQDMFVSDLTQRKGVILVDYGSVWRDHRRFALMTLRNFGLGKISMEERIHEEIQFTISKLEENIGKTLSPKFMFHNAASNIICKVLFNTRYDYEDGKISEIVQGFVEMLQIANGPWAM--MY---DAFPWIRSFPLPF---NKAFRNMENFLNLAKRLVNEHKMS-RVAGEPRDFVDSYLDELEKNKKD------FSEQQLLRMTFDLYIAGTDTTSNTMLAGFLYLMVYPHIQEKCQREIDQMLERKDRVSFEDRHKMPYMQAVIHEVQRFANIVPLSVFHCTTKDSELSGYTIPKGTLIIQNMVSVLREEGQWKFPHEFNPENFLN----DQGEFIKPEAFMPFSAGPRMCLGEGLARMELFIIMVTLLRKFKFTWPEDAGQPDLSPVFGAT 470          

Query:  217 KNLNLLQGPTGWPLIGNINSFNEPLWMVLYK-YSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTE-LTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLS 1629
            K  N   GP   P IG+++     +  + +K ++  YG++F   +     V+L+ +K+L + L ++G++F  R Q  L      N GI+ T    W  QR FAL  LR+FG GK+  ++ +  EC  + +   E  GK   A+ L   A  N+I  LV   RFE   K++ + L  L E      +F    + ++P L    F  P    ++  +K       F+   I++HK+  +     +D+ID FL E  K   E   +  F  + L    L+LF AG ETT+TTL W +L +  +P+IQE+V+ EI  ++G+ + P+ ADK+ + YT AV+ EI R+  +VP+ ++     +T +D   IPK ++I P L     DE+VWE P  F P+HFLN + +    +  R+   PF  GKR CLGE LAR+E F+F T  +Q+F   F     E+       G  G IR+P S
Sbjct:   36 KPKNFPPGPRSLPFIGDLHRIRPTILHLQFKEFAAKYGNVFSLNIFGGKTVVLNGTKLLKEALIQKGDDFVDRPQIPLFSDLIENKGIVMTNGIQWKHQRRFALHTLRNFGLGKKTMEKYIQEECHYITQAFAEHQGKPFDAQPLLNSAVSNIICCLVFGERFEYSDKEYQQILQDLTEVVKLQGSFSALAYNVFPWLMKR-FPGPLQKLFTLVDKIMD----FVKIKIEEHKENLDPACP-KDYIDSFLIEMEKNQGE---DFGFDIKNLCACTLDLFGAGSETTTTTLYWGLLFMIHYPDIQEEVHAEIDAVIGSSRQPSMADKENMPYTDAVIHEIQRMGDIVPIGVARMASRDTMLDNYTIPKGTMIMPALHTVLHDESVWETPHSFNPQHFLNQDGT----FKKREAFFPFGAGKRVCLGEQLARMELFLFFTSFLQRFS--FSTAGGEK---PPLEGRMGTIRSPKS 490          

Query:  151 IFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNIN--SFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTE-KEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILT-LFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKI 1590
            +F++L +    I   F      +  N   GP   P++GN+   S + PL     +    YG+++   +G +  VI++  K + + +  +  +F+GR Q+  +   ++  G++  +  E W   R FAL  LR+FG GK+  +E +S E    +K +E   GK+ S + +F  A  N+I +++   RFE D     E+ K I +    N+ I    + M  I D++P I    L +    K A+I      +++++HK+   I  +  DF+D +L E  K  ++     +F++ QLI   L+L FAG +TTS TL      L  +P IQ+K  QEI  +L  ++   F D+  + Y QAV+ E+ R++  VPLS+ H   + TE+ G  IPK ++I  N+ +  R++  W+ P +F PE+FLN       ++   +  +PFS G R CLGEGLAR+E FI +  +++KFK  +  +  E +F  +
Sbjct:    1 MFVSLILLWLCICILFLQLKPRRPKNFPPGPPVLPMLGNLLHLSLDNPL-KDFDRLRNSYGNVYSLFLGPKPAVIINGFKAMKEAMVIKATDFAGRPQDLFVNDVSKRKGVILADYGESWRDHRRFALMTLRNFGLGKKSMEERISEEIQHTIKTLENNIGKLFSPQIMFHNAASNIICQVLFGKRFEYDD----EIIKTIVQCFTRNSKIANGPWAM--IYDSIPLIRKLPLPFREAFKNAEICVDVGTHLVNEHKET-RIPGKPRDFVDCYLDEMEKRGDDS----SFSEDQLIIYALDLHFAGTDTTSNTLLTGFFYLINYPHIQDKCQQEIDRVLEEKQQVTFEDRHNMPYMQAVIHEVQRIANTVPLSVFHSTTKETELMGYTIPKGTMIIQNMGSVLREDGQWKFPHDFNPENFLNEKG----EFVKPEAFMPFSAGPRMCLGEGLARMELFIIMVTLLRKFKFTWPEDAGEPDFTPV 468          

Query:  133 MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELRI 1656
            MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYETTSTTLSWSMLLLAKHP IQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELRI
Sbjct:    1 MDNFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYETTSTTLSWSMLLLAKHPNIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELRI 508          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            V++ I L + +YF+ K     S  K L  LQGP+GWPLIGN+ +  EPLW  LYK +  YG LFK+TMG RDIV++SS+K+L K LKE+G  FSGR++N +      NSGILFT+ EWWATQRSFALKVL+DFGFGKQRS EI+S+EC  LLK+IEE CGKV+SARSLFPK TVNVIAKL MNMRFE D+ +F  LT  +E+  QN NFI+T+  MYPIL+  P IA  LL +SGR +  +        II++HKKRFN+ENEGEDFID+FL+E+++L+ EKV NHTFTD QL+RV+ ELF AGYETTSTTL+W+M+L+AK+ EIQ+KV++EIV+++G+E++PN +DKK L YTQAVMDEI RV++VVPLS+ HR+ EN+E++G +IPK+SIIFPNL+ACHRD  VW++PFEFYPEHFL   ++G +KY+P DELVPFSIGKRQCLGE LAR+EFFIF T I+Q+FK++FE EIS + +AK+T GTDG IRAPLSSDVVFE+R
Sbjct:    7 VIVVIALALPIYFLSKLMTRPSIPKGLKPLQGPSGWPLIGNLFTIKEPLWSFLYKQTFKYGPLFKFTMGCRDIVVISSNKILSKALKEKGIPFSGRWKNIIAITLVHNSGILFTDGEWWATQRSFALKVLKDFGFGKQRSTEIISHECAFLLKEIEESCGKVISARSLFPKCTVNVIAKLAMNMRFERDTPNFKFLTANVERVAQNKNFIVTILLMYPILEEYPRIAKLLLRFSGREQEFEEMHAHFRAIIEEHKKRFNVENEGEDFIDMFLREKYELDNEKVLNHTFTDWQLVRVIFELFVAGYETTSTTLTWTMILMAKNLEIQDKVHKEIVNIIGSERIPNVSDKKSLPYTQAVMDEIFRVTSVVPLSLPHRLLENSEINGTFIPKNSIIFPNLYACHRDAEVWKRPFEFYPEHFLTEESNGSIKYSPMDELVPFSIGKRQCLGEALARMEFFIFFTSIMQRFKVKFEKEISVDAYAKMTMGTDGTIRAPLSSDVVFEIR 509          

Query:  145 VLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMP-FIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            VLI I L I LYF+ + F        L  LQGP+GWPL+GN+ S  EPLW + YK++K YG +FK+ +G R++VI++SSK+LFKTLK+QG NFSGR QN LIK  T + GI+F EKEWW+TQRSFALKVLRDFG GKQRS EIV+NEC ILL+++EE  GK +  +S FP  TVN+IAKL+MNMRFE +S +F E  K+IE+   N +F++ LFQ+Y     +P F  PF+  +SG          F+ NII++ KK F+ ENEG+DFID+FL E+HKL  E VKNHTFTD QLIR+V+ELF AG+E+TSTTLSW+M+LLA+H EIQ+KV+QEI++L+G +K+P+  +KK L YTQAVMDEILR+STV PL++ HRVF + EV+G YIPKDS IF NL+ACHRDE VWEKPF+FYPEHFL   ++G++KYTPR+ELVPFS GKRQC GE LAR+E+F+FLT I+QKFKI+F   I +  + KITRGTDG +RAPL  D++FE+R
Sbjct:    7 VLISIFLVIILYFLSRKFSTNPIPIGLRPLQGPSGWPLVGNLFSIKEPLWSIFYKHAKTYGEIFKFKLGNRELVIINSSKILFKTLKDQGVNFSGRQQNDLIKYITHDCGIVFKEKEWWSTQRSFALKVLRDFGLGKQRSIEIVNNECSILLQELEETSGKNICTKSCFPSVTVNIIAKLLMNMRFEKNSSEFFEFRKIIEQTTHNRSFLVILFQIY----TLPHFTIPFIARFSGLRNHIDAVHNFVINIINERKKTFSHENEGQDFIDMFLIEKHKLESENVKNHTFTDWQLIRMVVELFGAGFESTSTTLSWAMVLLARHTEIQDKVHQEIINLIGVDKIPDLNNKKFLHYTQAVMDEILRISTVAPLAVPHRVFNDAEVEGFYIPKDSTIFTNLYACHRDEKVWEKPFDFYPEHFLTKLDNGEMKYTPREELVPFSTGKRQCPGESLARLEYFVFLTSILQKFKIKFNKAIDDITYEKITRGTDGTVRAPLDVDLIFEMR 506          

Query:  139 NFVLIFITLGIALYFIKKFFFNQSASKNLNLLQGPTGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
             F+LIF      LYF+          K L  +   +G P+IG I+    P+   L K  +  G +F+  +G R IV+L++ +M+ K L +  NNFSGR+    IK  T +SGI+F + + WATQRSF LKVLRDFG GK +S EIV NEC   L +++   G++V    L P  T N+I++ +MN RF  D  +   + + I  + +N + I  +  M+P  DN   I   +   + + K+      +    I++H+   ++ +EGED +D FL +QH+L +      +F D QLIR  +ELF AGYETTSTTL+W  L ++K+P+IQEKV++EI +++G E+LP   DKK L YTQAVMDE+LR+S+V P+ + HR F++  ++G YIPKDS+IFPNL+ACH D  +WE P  FYPEHFL+++++G  KY PR+EL+PFS+GKRQCLGE LAR E+FIF   ++Q+F+I F  EISE+++++   G +G IR     + +F+ R
Sbjct:    8 TFILIF------LYFLYWVCRKPPIPKGLKEIPMESGLPIIGAIHKIEPPMHHYLLKLGRKLGPIFRIKLGMRKIVVLNNYEMIKKALIDDANNFSGRWSQRFIKEITHDSGIIFKDGKIWATQRSFILKVLRDFGLGKSKSIEIVQNECFNFLDELDTLSGQIVDFSELIPIYTTNIISRFIMNKRFTRDDPNIQLIEETINNSTKNKDIIQLILLMFPCFDNSSLICQLIYLLTSKWKSFVKIQNYFGEEIEEHRTNLDLTSEGEDLMDRFLIKQHELKQSTGNVESFVDWQLIRTSVELFIAGYETTSTTLNWCCLFMSKYPDIQEKVHKEISEIIGKERLPTMNDKKALNYTQAVMDEVLRLSSVAPMGLIHRTFDDANINGFYIPKDSLIFPNLYACHMDPEIWESPTTFYPEHFLSLDSNGISKYQPREELIPFSVGKRQCLGESLARSEYFIFFVSMVQRFQISFAEEISEDKYSQTIIGNEGVIRTSDIKNFLFKRR 506          

Query:  154 FITLGIALYFIKKFFFNQSASKNLNLLQGP--TGWPLIGNINSFNEPLWMVLYKYSKHYGSLFKYTMGRRDIVILSSSKMLFKTLKEQGNNFSGRFQNFLIKARTRNSGILFTEKEWWATQRSFALKVLRDFGFGKQRSQEIVSNECMILLKDIEEECGKVVSARSLFPKATVNVIAKLVMNMRFESDSKDFTELTKLIEKAIQNNNFILTLFQMYPILDNMPFIAPFLLWWSGRNKTAKITSKFINNIIDDHKKRFNIENEGEDFIDIFLKEQHKLNEEKVKNHTFTDQQLIRVVLELFFAGYEXXXXXXXXXXXXXAKHPEIQEKVYQEIVDLLGTEKLPNFADKKCLQYTQAVMDEILRVSTVVPLSISHRVFENTEVDGVYIPKDSIIFPNLFACHRDENVWEKPFEFYPEHFLNINNSGQLKYTPRDELVPFSIGKRQCLGEGLARIEFFIFLTGIIQKFKIRFENEISEEEFAKITRGTDGGIRAPLSSDVVFELR 1653
            F  + I  YF K++   Q   +N    Q P   G PLIG++     PL + L   S+ YG +++  +G R+I++ +S ++L +T K  GN+FSGR+   L K  T +SGI+FT+ E WA QR+F  KVLRDFG G+ +S EIV  EC   L +I++  GK V    L P  T+N+I+K +MN RF  +      + K++  +++  +F+L  + ++P  +N   +  F +  +   K        +N  I+ H+K  ++ ++GED ID FL EQ K+ E+     TFT+ QLIR   E+  AGYETTSTTL WS++ +++H +IQEKVY+EIV ++G EKLP+  DKK + YTQA+MDEILR+S+V PL+  HR   +    G ++PKD++IFPNL+ACH D +VW  P EFYP HFL+ +++  +KY PR+EL+PF IGKRQCLGE LAR+E+FIF   I+Q+FK+RF  E++E  + ++ RG DG IR  L ++ +FE R
Sbjct:    8 FCIILILYYFGKRWRSRQRILRN----QAPLVKGLPLIGSLLDIKLPLHIYLKDLSQIYGPVYRIKLGFREILVFNSFEILKQTFKLDGNSFSGRWSTCLFKVLTHDSGIIFTDGEVWAKQRAFMQKVLRDFGVGRSKSSEIVQFECESCLDEIKQLAGKKVDFSQLIPIYTLNIISKFIMNKRFCREDPKLKFMQKMMLDSLKKIDFVLIFYLVFPYFENSSLVFKFFMKLTTHLKMVLKIYDSLNEEIETHQKLLDLNSDGEDMIDRFLLEQKKVMEKTGSVDTFTEWQLIRNSFEMLVAGYETTSTTLVWSLMFMSRHQDIQEKVYKEIVSVIGKEKLPSINDKKDMDYTQAIMDEILRMSSVTPLASFHRAMIDCSAKGFFVPKDTLIFPNLYACHFDPDVWSNPSEFYPNHFLSTDDNIPMKYCPREELIPFGIGKRQCLGESLARMEYFIFFCSILQRFKVRFAEEMTEMRYQEVLRGNDGVIRICLETNFIFEER 505