2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Overview
Name2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Smed IDSMED30004597
Length (bp)1355
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (SMED30004597) t-SNE clustered cells

Violin plots show distribution of expression levels for 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (SMED30004597) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (SMED30004597) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (SMED30004597) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004597

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30004597SMESG000039807.1 SmedASXL_007125SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30004597SMESG000039807.1 SmedASXL_007125SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Match: DPH1 (diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003])

HSP 1 Score: 437.187 bits (1123), Expect = 1.110e-150
Identity = 209/374 (55.88%), Postives = 274/374 (73.26%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN 1174
            N+IP  I+ N  L  AI ++LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCL+P+D S    +  YVFV I ID  H +DS+ + F   + L LV+TIQF+STLQA   EL  ++ V++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPYSK ++RE YDH  MQ+ R  AI TAR AK++G+ILGTLGRQGS  +L+ + + ++  GL+ V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH 
Sbjct:   35 NQIPPEILKNPQLQAAI-RVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHG 399
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Match: DPH1 (diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003])

HSP 1 Score: 396.741 bits (1018), Expect = 4.756e-135
Identity = 200/374 (53.48%), Postives = 263/374 (70.32%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN 1174
            N+IP  I+ N  L  AI ++LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCL+P+D S    +  YVFV I ID  H +DS+ + F   + L L A             EL  ++ V++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPYSK ++RE YDH  MQ+ R  AI TAR AK++G+ILGTLGRQGS  +L+ + + ++  GL+ V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH 
Sbjct:   34 NQIPPEILKNPQLQAAI-RVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALAAA-----------QELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHG 387
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Match: DPH1 (diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003])

HSP 1 Score: 387.497 bits (994), Expect = 2.129e-132
Identity = 186/336 (55.36%), Postives = 244/336 (72.62%), Query Frame = 2 
Query:  209 LPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKH 1201
            +PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCL+P+D S    +  YVFV I ID  H +DS+ + F   + L LV+TIQF+STLQA   EL  ++ V++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPYSK ++RE YDH  MQ+ R  AI TAR AK++G+ILGTLGRQGS  +L+ + + ++  GL+ V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH      RR H
Sbjct:    1 MPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHGQD---RRPH 325
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Match: DPH1 (diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003])

HSP 1 Score: 123.25 bits (308), Expect = 6.977e-33
Identity = 63/115 (54.78%), Postives = 79/115 (68.70%), Query Frame = 2 
Query:  857 LGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKH 1201
            LGRQGS  +L+ + + ++  GL+ V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH      RR H
Sbjct:    2 LGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHG---QDRRPH 110
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Match: DPH1 (diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003])

HSP 1 Score: 89.7373 bits (221), Expect = 3.242e-21
Identity = 44/69 (63.77%), Postives = 47/69 (68.12%), Query Frame = 2 
Query:  995 FIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKH 1201
            ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH      RR H
Sbjct:    2 WVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHGQD---RRPH 65
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Celegans
Match: dph-1 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:P49958])

HSP 1 Score: 404.445 bits (1038), Expect = 5.085e-139
Identity = 202/399 (50.63%), Postives = 282/399 (70.68%), Query Frame = 2 
Query:   47 ANKKSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPL---DCSKTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSK---KFTVTIPKSAPLSFGEILGCTAPTV--ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN---PAKLIRRKHIVV 1210
            A + +  + + + I NN  L + + ++LP NY FE+ KTI +IR   +K +ALQ PEGL ++ACV++DIL K+        D +IMGDVTYGACC+DDYT++++ CDLL+HYGHSCLVP+   D     YVFV I+I++ H ID V  NF  G  LV+V+T+QFI +LQ +RT  +K      + IP+  PLS GE+LGCT+P +  +  D I+YLGDGRFHLE++M+ NP + AF+YDPYS+++TRE YDH LM+ NR+ +I  ARK  TFG+I GTLGRQG+  V++ + A ++++G   + +LLSE+FP KL MF + +D ++Q+ACPRLSIDWGT F KPLL P+E AVAL     +P+DH+PMD+Y++DSLG WT N+    P +  R+ HIVV
Sbjct:    2 ATRATQISTLVEEIANNPNLKEDL-KILPSNYTFEVPKTIWKIRSTESKYVALQFPEGLIMYACVIADILEKYT-----GCDTVIMGDVTYGACCVDDYTAKSMGCDLLVHYGHSCLVPIQNTDGIAMLYVFVNIHINLSHLIDCVKENFQ-GKRLVVVSTVQFIPSLQTLRTTFNKDDSSIRIDIPQCKPLSPGEVLGCTSPRLDASKYDAIVYLGDGRFHLESIMIHNPEIEAFQYDPYSRKLTREFYDHDLMRKNRIGSIEIARKCTTFGLIQGTLGRQGNLKVVEELEAQLERKGKKFLRVLLSEIFPEKLAMFPE-VDCWVQVACPRLSIDWGTQFPKPLLYPFELAVALDNIS-VPSDHWPMDYYSNDSLGPWTNNNEANRPKREKRKPHIVV 391
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Celegans
Match: dph-2 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q09454])

HSP 1 Score: 71.2478 bits (173), Expect = 4.414e-13
Identity = 83/356 (23.31%), Postives = 155/356 (43.54%), Query Frame = 2 
Query:  146 FEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDIL-SKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSC-LVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDD------GSHLVLVATIQFISTLQAVRTELSKKFTVT-------IPKSAPLSFGE---ILGCTAPTV----ADADFILYLGDGRFHLEAVMMANPNLPAF-RYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACP-RLSIDWGTFFQKPLLTPYEAAVALGIAQ-WMPNDHYPMDFYA 1138
            FEI  T   I+  N +RIALQ P+ L  ++  ++ ++ S+F  E+++     ++ D +Y +CC+D+  +   DC  L+H+G +C   P D     YV   + I    FID   + F +        H+VL+    F    + V   + +            +P    L        LG   P+        D I         L   +++ P+      ++P +K I  E    S +   RL  +   + A T G+++G++G       +  +    ++ G    +I + ++   KL  F   ID F+ ++CP  + +D   +F +P+++ +EA +AL  A+ W  +  +  +F A
Sbjct:   42 FEIDATSEWIKQGNHQRIALQFPDSLLPYSEKVTKLIESRFRSESAK--KTFVLADTSYRSCCVDEVAAAHADCTALVHFGEACHSAPTDKIDVKYVLGSMPI----FIDQFRMEFQNVADQLTAEHIVLLMDSCFSHEQEKVAAVIKEVLPGNRHVECSLLPSEDVLKQNRQNIYLGREIPSCLRNNQPTDLIFCGFPNSPLLPIWLLSYPSCSTVSHFNPINKTIQHESTRSSRLLRKRLFLVEKLKDADTVGLVVGSVGVDKHREAVKRMREMCKKAGKKIYVISVGKINVPKLSNFSTDIDVFVLLSCPFGVVLDSSDYF-RPVVSYFEAEIALNPAKTWAADFGWSAEFAA 390
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Fly
Match: Dph1 (gene:FBgn0036194 transcript:FBtr0076131)

HSP 1 Score: 433.335 bits (1113), Expect = 2.432e-149
Identity = 215/386 (55.70%), Postives = 280/386 (72.54%), Query Frame = 2 
Query:   56 KSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFD-DGSHLVLVATIQFISTLQAVRTEL-SKKFTVTIPKSAPLSFGEILGCTAPTVADA-DFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMP------NDHYPMDFYAHDSLGKWTPNHNP 1177
            K+  N+IP  ++++ LL QAI++L P NYNFE+HKTI RIR + AKR+ALQLPEGL ++A V+SDI+ +F        D +IMGDVTYGACC+DDYT++AL  DLL+HYGHSCL+P+D +   K  Y+FV I ID  HF+DSV +NF  +   + LV+TIQF++TLQA  TEL +  + V +P++ PLS GEILGCT+P + +    I+YLGDGRFHLE+ M+ANP L A++YDPY K+ T E+YDHS MQ+ RL+A+  A+KA+  GIILGTLGRQGSS V   +   +  +G+    +LLSE+FP KL +F D IDAF+QIACPRLSIDWG+ F +PLL PYE +V LG  +W P      N+ YPMDFYA  SLG WTPN  P
Sbjct:   33 KARINRIPQELLDDPLLQQAIDRL-PSNYNFEMHKTIWRIREMKAKRVALQLPEGLLMYAMVISDIVERFTS-----ADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTCGIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKAAGYDVIVPQAKPLSPGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFAD-IDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPNFKP 411
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Fly
Match: Dph1 (gene:FBgn0036194 transcript:FBtr0332766)

HSP 1 Score: 433.335 bits (1113), Expect = 2.432e-149
Identity = 215/386 (55.70%), Postives = 280/386 (72.54%), Query Frame = 2 
Query:   56 KSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFD-DGSHLVLVATIQFISTLQAVRTEL-SKKFTVTIPKSAPLSFGEILGCTAPTVADA-DFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMP------NDHYPMDFYAHDSLGKWTPNHNP 1177
            K+  N+IP  ++++ LL QAI++L P NYNFE+HKTI RIR + AKR+ALQLPEGL ++A V+SDI+ +F        D +IMGDVTYGACC+DDYT++AL  DLL+HYGHSCL+P+D +   K  Y+FV I ID  HF+DSV +NF  +   + LV+TIQF++TLQA  TEL +  + V +P++ PLS GEILGCT+P + +    I+YLGDGRFHLE+ M+ANP L A++YDPY K+ T E+YDHS MQ+ RL+A+  A+KA+  GIILGTLGRQGSS V   +   +  +G+    +LLSE+FP KL +F D IDAF+QIACPRLSIDWG+ F +PLL PYE +V LG  +W P      N+ YPMDFYA  SLG WTPN  P
Sbjct:   33 KARINRIPQELLDDPLLQQAIDRL-PSNYNFEMHKTIWRIREMKAKRVALQLPEGLLMYAMVISDIVERFTS-----ADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTCGIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKAAGYDVIVPQAKPLSPGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFAD-IDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPNFKP 411
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Fly
Match: Dph1 (gene:FBgn0036194 transcript:FBtr0076130)

HSP 1 Score: 433.335 bits (1113), Expect = 2.432e-149
Identity = 215/386 (55.70%), Postives = 280/386 (72.54%), Query Frame = 2 
Query:   56 KSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFD-DGSHLVLVATIQFISTLQAVRTEL-SKKFTVTIPKSAPLSFGEILGCTAPTVADA-DFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMP------NDHYPMDFYAHDSLGKWTPNHNP 1177
            K+  N+IP  ++++ LL QAI++L P NYNFE+HKTI RIR + AKR+ALQLPEGL ++A V+SDI+ +F        D +IMGDVTYGACC+DDYT++AL  DLL+HYGHSCL+P+D +   K  Y+FV I ID  HF+DSV +NF  +   + LV+TIQF++TLQA  TEL +  + V +P++ PLS GEILGCT+P + +    I+YLGDGRFHLE+ M+ANP L A++YDPY K+ T E+YDHS MQ+ RL+A+  A+KA+  GIILGTLGRQGSS V   +   +  +G+    +LLSE+FP KL +F D IDAF+QIACPRLSIDWG+ F +PLL PYE +V LG  +W P      N+ YPMDFYA  SLG WTPN  P
Sbjct:   33 KARINRIPQELLDDPLLQQAIDRL-PSNYNFEMHKTIWRIREMKAKRVALQLPEGLLMYAMVISDIVERFTS-----ADTVIMGDVTYGACCVDDYTAKALGADLLVHYGHSCLIPVDQTCGIKVLYIFVDIKIDPLHFLDSVKLNFRPEVGQIALVSTIQFVTTLQAASTELKAAGYDVIVPQAKPLSPGEILGCTSPQLPETTKMIIYLGDGRFHLESAMIANPLLKAYKYDPYEKKFTTEQYDHSAMQNLRLDAVQRAKKARRIGIILGTLGRQGSSRVHRFLEKRLHAKGIETTTLLLSEIFPQKLALFAD-IDAFVQIACPRLSIDWGSAFSQPLLNPYELSVVLGDVEWTPHNSSPRNNAYPMDFYASGSLGPWTPNFKP 411
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Fly
Match: CG7265 (gene:FBgn0038272 transcript:FBtr0083009)

HSP 1 Score: 74.3294 bits (181), Expect = 5.708e-14
Identity = 76/342 (22.22%), Postives = 146/342 (42.69%), Query Frame = 2 
Query:  116 IEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVM----VNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFI-LYLGDGRFHLEAVMMANPNLPAFR-YDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYP 1123
            +EQ+   N+      ++  IR    KR+ LQ P+     +  +S  L +      E V + I+ D TYG+CC+D+  +  +D D +IH+G++C          Y++  + +D+   +  +      + D    + L    Q +   + ++ +LS+               E    T     + + I +++G        + +  P    +  YD  S  ++ +    +     R   I   + A+T G+I+ TL  +G   V+  +    + RG+   +I +  + P KL  F + ID F+ I CP  ++     + KP+++ +EA +AL  A  M    YP
Sbjct:   31 LEQIWNENHR---RSSVDWIRKSGYKRVCLQFPDDYLPHSNAISVGLKELL--APEDVKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNACRSRAARLPVLYLYPELPLDVNVLLSKLQGLRAESIDRQVCVYLDIGYQHVYG-EKLKKQLSEILEPKELLLELFPPIEAESTTTRETTNLERICIFIGADNQRFANLSLTAPAAVQWHIYDGSSDSLSSKNPLTAQFIRRRYFHIEKCKDAQTLGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLE-IDCFVLIGCPFNNMYDSKEYYKPIVSVFEAEMALNPAWHM---RYP 362
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Zebrafish
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:550559])

HSP 1 Score: 338.576 bits (867), Expect = 6.889e-113
Identity = 165/313 (52.72%), Postives = 227/313 (72.52%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDA 994
            N+IP+ I+ +  LN+AI+ L P NYNFEIHKTI R+R   AKR+ALQLPEGLQ+FACV++DI+ +F        D ++MGDVTYGACC+DD+T+RAL  D ++HYGHSCL+P+D +   K  YVFV I ID  HF+D++  NF  G  L LV+TIQF++ LQA    L   + V +P+  PLS GEILGCT+P +    + ++YLGDGRFHLE++M+ANP+ PA+RYDPYSK  +RE YDH  M++ RL AI +AR A+ +G+ILGTLGRQG+  +L+ + + ++  G +   +LLSE+FP KL++  D +DA
Sbjct:   45 NQIPEEILKDSDLNEAIKAL-PANYNFEIHKTIWRVRQAKAKRVALQLPEGLQMFACVIADIIERFTE-----ADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTEGIKMLYVFVDIQIDTAHFLDTLRFNFPPGRSLALVSTIQFVAALQAASAALKPDYEVLVPQCRPLSPGEILGCTSPRLDKHVNAVIYLGDGRFHLESIMIANPDTPAYRYDPYSKVFSREYYDHDAMRATRLKAIESARSAQRWGLILGTLGRQGNPKILEHLESQLKSLGRSFTRVLLSEIFPRKLELLAD-VDA 350
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Zebrafish
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:550559])

HSP 1 Score: 88.9669 bits (219), Expect = 2.939e-21
Identity = 41/71 (57.75%), Postives = 55/71 (77.46%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENS 280
            N+IP+ I+ +  LN+AI + LP NYNFEIHKTI R+R   AKR+ALQLPEGLQ+FACV++DI+ +  +  S
Sbjct:   28 NQIPEEILKDSDLNEAI-KALPANYNFEIHKTIWRVRQAKAKRVALQLPEGLQMFACVIADIIERVLFRMS 97
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Zebrafish
Match: dph2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:562538])

HSP 1 Score: 91.2781 bits (225), Expect = 2.555e-19
Identity = 83/343 (24.20%), Postives = 147/343 (42.86%), Query Frame = 2 
Query:  191 KRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDD-GSHLVLVATIQFISTLQAVRT----------------------ELSKKFTVTIPKSAP---LSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPN--LPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGI-AQWMPNDHYPMDF 1132
            K++ALQ P+ L   A  +S  +     E+       I+GD +YG+CC+D+  +  +  D ++HYG SCL P       YVF    ID+     S    + +  SH++++  + +   +  +RT                      EL +   V +  +       FG           +   I Y+G     L   MM+  N    +F  +  +  +   + + +LM+  R  AI  A+ A   GI++GTLG      +++ +   IQ+ G    +  + ++   KL  F + ID ++ +ACP  S+   + F +P++TP+E  +A     +W     Y  DF
Sbjct:   48 KKVALQFPDELLPDAVRVSAEI-----EDKTKAKTYILGDTSYGSCCVDEVAAEHVGADCIVHYGSSCLSPCRRLPLLYVFGKRPIDVHQCASSFKELYPNLQSHIIVLFDVTYSHAIDDLRTLLCDVYPNVVVSRLKTDHSCGAELIQDSCVDLQSNDDGVIFKFGRQFRIKEGQTVNDYSIFYIGQEGLTLTNFMMSWNNCVFSSFNPETSTGRVESVQINKALMK--RYYAIERAKDASVVGILVGTLGVANYLIIIEQLKDTIQRAGKKSYMFAMGKINVPKLANFLE-IDIYVLVACPENSLLDSSEFYRPVVTPFEMELACNKHREW--TGEYVTDF 380
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Zebrafish
Match: dph2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:562538])

HSP 1 Score: 56.9954 bits (136), Expect = 4.556e-9
Identity = 37/126 (29.37%), Postives = 62/126 (49.21%), Query Frame = 2 
Query:  191 KRIALQLPEGLQLFACVLSDILSKFAY-ENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDD-GSHLVLVATIQFISTLQAVRTEL 562
            K++ALQ P+ L      L D +   A  E+       I+GD +YG+CC+D+  +  +  D ++HYG SCL P       YVF    ID+     S    + +  SH++++  + +   +  +RT L
Sbjct:   48 KKVALQFPDEL------LPDAVRVSAEIEDKTKAKTYILGDTSYGSCCVDEVAAEHVGADCIVHYGSSCLSPCRRLPLLYVFGKRPIDVHQCASSFKELYPNLQSHIIVLFDVTYSHAIDDLRTLL 167
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Match: cenpj (centromere protein J [Source:Xenbase;Acc:XB-GENE-1013036])

HSP 1 Score: 432.95 bits (1112), Expect = 6.684e-149
Identity = 205/379 (54.09%), Postives = 276/379 (72.82%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            N+IPD I +N LL +A+ ++LP NYNFEI KTI RI+  +AKR+ALQ+PEGL +FAC ++DI+ +F        + ++MGDVTYGACC+DDYT++AL  D ++HYGHSCL+P+D +   +  YVFV I ID  HF+D++  NF  G+ L LV+T+QF+S LQA    L   + VT+P+  PLS GEILGCT+P +    D ++YLGDGRFHLE+VM++NP+  A+RYDPYSK  +RE YDHS M  +R  AI  A  AKT+G+ILGTLGRQGS  +L+ + + +Q  G  +V +LLSE+FPNKL +F + ++ ++Q+ACPRLSIDWGT F +PLLTPYEA+VAL  A+W     YPMDFYA++SLG WT NH   +  R
Sbjct:   52 NQIPDEISHNPLLLEAM-KVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACTIADIIERFTS-----AETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQPGASLALVSTVQFVSALQAAHQALRMDYKVTVPQCKPLSPGEILGCTSPKLDKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSAMLKHRGEAISAAAGAKTWGLILGTLGRQGSPKILEHLESRLQALGCRYVRLLLSEIFPNKLKLFPE-VEVWVQVACPRLSIDWGTAFSRPLLTPYEASVALKEAEW--QHTYPMDFYANESLGPWTVNHESHRPTR 421
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Match: cenpj (centromere protein J [Source:Xenbase;Acc:XB-GENE-1013036])

HSP 1 Score: 431.409 bits (1108), Expect = 1.034e-148
Identity = 205/379 (54.09%), Postives = 276/379 (72.82%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            N+IPD I +N LL +A+ ++LP NYNFEI KTI RI+  +AKR+ALQ+PEGL +FAC ++DI+ +F        + ++MGDVTYGACC+DDYT++AL  D ++HYGHSCL+P+D +   +  YVFV I ID  HF+D++  NF  G+ L LV+T+QF+S LQA    L   + VT+P+  PLS GEILGCT+P +    D ++YLGDGRFHLE+VM++NP+  A+RYDPYSK  +RE YDHS M  +R  AI  A  AKT+G+ILGTLGRQGS  +L+ + + +Q  G  +V +LLSE+FPNKL +F + ++ ++Q+ACPRLSIDWGT F +PLLTPYEA+VAL  A+W     YPMDFYA++SLG WT NH   +  R
Sbjct:   21 NQIPDEISHNPLLLEAM-KVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACTIADIIERFTS-----AETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQPGASLALVSTVQFVSALQAAHQALRMDYKVTVPQCKPLSPGEILGCTSPKLDKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSAMLKHRGEAISAAAGAKTWGLILGTLGRQGSPKILEHLESRLQALGCRYVRLLLSEIFPNKLKLFPE-VEVWVQVACPRLSIDWGTAFSRPLLTPYEASVALKEAEW--QHTYPMDFYANESLGPWTVNHESHRPTR 390
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Match: cenpj (centromere protein J [Source:Xenbase;Acc:XB-GENE-1013036])

HSP 1 Score: 429.098 bits (1102), Expect = 1.569e-147
Identity = 205/379 (54.09%), Postives = 276/379 (72.82%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            N+IPD I +N LL +A+ ++LP NYNFEI KTI RI+  +AKR+ALQ+PEGL +FAC ++DI+ +F        + ++MGDVTYGACC+DDYT++AL  D ++HYGHSCL+P+D +   +  YVFV I ID  HF+D++  NF  G+ L LV+T+QF+S LQA    L   + VT+P+  PLS GEILGCT+P +    D ++YLGDGRFHLE+VM++NP+  A+RYDPYSK  +RE YDHS M  +R  AI  A  AKT+G+ILGTLGRQGS  +L+ + + +Q  G  +V +LLSE+FPNKL +F + ++ ++Q+ACPRLSIDWGT F +PLLTPYEA+VAL  A+W     YPMDFYA++SLG WT NH   +  R
Sbjct:   27 NQIPDEISHNPLLLEAM-KVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACTIADIIERFTS-----AETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQPGASLALVSTVQFVSALQAAHQALRMDYKVTVPQCKPLSPGEILGCTSPKLDKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSAMLKHRGEAISAAAGAKTWGLILGTLGRQGSPKILEHLESRLQALGCRYVRLLLSEIFPNKLKLFPE-VEVWVQVACPRLSIDWGTAFSRPLLTPYEASVALKEAEW--QHTYPMDFYANESLGPWTVNHESHRPTR 396
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Match: cenpj (centromere protein J [Source:Xenbase;Acc:XB-GENE-1013036])

HSP 1 Score: 418.313 bits (1074), Expect = 4.501e-144
Identity = 196/361 (54.29%), Postives = 263/361 (72.85%), Query Frame = 2 
Query:  122 QLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            ++LP NYNFEI KTI RI+  +AKR+ALQ+PEGL +FAC ++DI+ +F        + ++MGDVTYGACC+DDYT++AL  D ++HYGHSCL+P+D +   +  YVFV I ID  HF+D++  NF  G+ L LV+T+QF+S LQA    L   + VT+P+  PLS GEILGCT+P +    D ++YLGDGRFHLE+VM++NP+  A+RYDPYSK  +RE YDHS M  +R  AI  A  AKT+G+ILGTLGRQGS  +L+ + + +Q  G  +V +LLSE+FPNKL +F + ++ ++Q+ACPRLSIDWGT F +PLLTPYEA+VAL  A+W     YPMDFYA++SLG WT NH   +  R
Sbjct:    2 KVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACTIADIIERFTS-----AETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQPGASLALVSTVQFVSALQAAHQALRMDYKVTVPQCKPLSPGEILGCTSPKLDKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSAMLKHRGEAISAAAGAKTWGLILGTLGRQGSPKILEHLESRLQALGCRYVRLLLSEIFPNKLKLFPE-VEVWVQVACPRLSIDWGTAFSRPLLTPYEASVALKEAEW--QHTYPMDFYANESLGPWTVNHESHRPTR 354
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Match: DPH2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:100135719])

HSP 1 Score: 111.694 bits (278), Expect = 4.282e-26
Identity = 107/444 (24.10%), Postives = 190/444 (42.79%), Query Frame = 2 
Query:   86 IINNVLLNQAIEQLLP---INYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNF-DDGSHLVLVATIQFISTLQAVRTELSKKFTVTI--------PKSAP---LSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIA-QW-----------MPNDHYPMDFYAHDSLGKWTPNHNPAKLI----RRKHIVVGE---KKMPETLVQMPTVS-----RSGAPACAEHEWEN 1300
            I  N+ + QA  Q  P   ++  +E  KT+  I+   A+++ALQ P+ L + +  ++  L     E +      I+GD +YG+CC+D+  +  +  ++L+HYG +CL P      FYVF    +++    ++ +  + D   H+V+++ + +   L  ++  +   +T  I          ++P   + FG           ++  I Y+G     L  +M+  P    F ++P + E   E    +     R   I  AR A   GI++GTLG       +  +   I   G    +  + ++ P KL  F + ID F+ +ACP  ++   + F KP++TP E  VA   A +W           +P     ++F   D       +H    LI    R  H+ V E   K +  +LVQ  + +      S A   A   W+ 
Sbjct:   14 ISRNIDIAQADIQSSPEKELDEFYETEKTVEFIQRNAAQKVALQFPDDLLVDSVTVARKL-----EEATGAKTYILGDTSYGSCCVDEVAAEHVKANVLVHYGRACLSPCCRLPVFYVFGRKAVNVDLCAEAFLSQYLDTDCHVVVLSDVVYDHALGELKKRIESAYTNVIFSKLSLCGGTASPDEIVKFGRRFSPDLSLWPESYSIFYVGGEGSTLSNLMLTWPRCTFFSFNPDTGEGRTEGLHINRALMKRFYLIERARDANVVGILVGTLGVSDYLLAIKHLQNIIHLAGKKSYMFSVGKLNPAKLANFPE-IDVFVLVACPENAMLDSSEFYKPVVTPDEMEVACNPAREWHGYCITNFRELLPGGSAYVEFPETDPSDA---HHTDVSLITGNLRSSHLTVTETPQKDLETSLVQRNSTTALTQMNSAASYLASRSWQG 448
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Mouse
Match: Dph1 (diphthamide biosynthesis 1 [Source:MGI Symbol;Acc:MGI:2151233])

HSP 1 Score: 438.728 bits (1127), Expect = 1.479e-151
Identity = 220/427 (51.52%), Postives = 289/427 (67.68%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPETLVQ-----MPTVSRSGAPACAEHEWENCTNCTC 1318
            N+IP  ++NN  L  A+ Q+LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCLVP+D S    +  YVFV I ID  H +DSV + F  GS L LV+TIQF+STLQA   EL   + +++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPY K ++RE YDH  MQ+ R  AI  AR AK++G+ILGTLGRQGS  +L+ + + ++  GL  V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWG+ F KPLLTPYEAAVAL    W     YPMDFY+  SLG WT N+             G  + P  L Q     +   SR G+PA A      C +C C
Sbjct:   30 NQIPPEVLNNPQLQAAV-QVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPGSSLALVSTIQFVSTLQAAAQELKADYHISVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNIPAYRYDPYGKVLSREYYDHQRMQATRQEAIAAARSAKSWGLILGTLGRQGSPKILEHLESQLRNLGLPFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISW--QQPYPMDFYSGSSLGPWTVNY-------------GRDRAPRGLCQPASDKVQQGSRGGSPAPA------CESCNC 428
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Mouse
Match: Dph1 (diphthamide biosynthesis 1 [Source:MGI Symbol;Acc:MGI:2151233])

HSP 1 Score: 313.153 bits (801), Expect = 1.080e-104
Identity = 148/266 (55.64%), Postives = 195/266 (73.31%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIIL 850
            N+IP  ++NN  L  A+ Q+LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCLVP+D S    +  YVFV I ID  H +DSV + F  GS L LV+TIQF+STLQA   EL   + +++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPY K ++RE YDH  MQ+ R  AI  AR AK++G+IL
Sbjct:   16 NQIPPEVLNNPQLQAAV-QVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPGSSLALVSTIQFVSTLQAAAQELKADYHISVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNIPAYRYDPYGKVLSREYYDHQRMQATRQEAIAAARSAKSWGLIL 275
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Match: sp|A7SLX5|DPH1_NEMVE (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Nematostella vectensis OX=45351 GN=dph1 PE=3 SV=1)

HSP 1 Score: 443.351 bits (1139), Expect = 3.924e-152
Identity = 226/422 (53.55%), Postives = 282/422 (66.82%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN---PAKLIRRKHIVVGEKKMPETLVQMPTVSRSGAPACAEHEWENCTNCT 1315
            N+IP+ I+ +  L +A    LP NYNFEIHKTI RI+ + AKR+ALQ PEGL LFAC ++DIL  F        + +IMGDVTYGACC+DDY++RAL CDLL+HYGHSCLVP+D +   K  YVFV I ID  HF++SV  N   GS L LV+TIQF++ LQA   ELSK + V IP+  PLS GEILGCTAP + D D ++YLGDGRFHLEAVM+ANP + A+RYDPY K  ++E YD   M   R  AI  A  A  +G+ILGTLGRQGS  VL ++   +Q   ++++I+LLSEVFP+KL +F D +DA++Q+ACPRLSIDWGT F KPLL+PYEA+VAL    W     YPMDFYA+ SLG WTPN+    P    RRK  +  E  +       P +  S    C   E   C  CT
Sbjct:   50 NQIPEEILKDTKLQEA----LPENYNFEIHKTIWRIQQVKAKRVALQFPEGLLLFACTIADILESFT-----GCETVIMGDVTYGACCVDDYSARALGCDLLVHYGHSCLVPIDATAGIKMLYVFVDIKIDTAHFVESVRFNLGAGSCLALVSTIQFVAALQAASNELSKDYQVEIPQCKPLSPGEILGCTAPMLKDKDAVIYLGDGRFHLEAVMIANPAIQAYRYDPYDKTFSKEYYDIDKMHEARQTAIKQASLASKYGLILGTLGRQGSPKVLQTLEKQLQSLNMDYIIVLLSEVFPDKLKLFKD-VDAWVQVACPRLSIDWGTAFPKPLLSPYEASVALQSVAW--QQSYPMDFYAYSSLGGWTPNNESNRPTPANRRKKNLHTEVIIDNVSDSKPVIKES---ECGSGE-TCCGKCT 455
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Match: sp|Q3SYT1|DPH1_BOVIN (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Bos taurus OX=9913 GN=DPH1 PE=2 SV=1)

HSP 1 Score: 441.81 bits (1135), Expect = 6.939e-152
Identity = 214/380 (56.32%), Postives = 277/380 (72.89%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            N+IP  I+NN  L  AI Q+LP NYNFE+ KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCLVP+D S    +  YVFV I ID  H +DS+ + F   S L LV+TIQF+STLQA   EL  ++ V++P+  PLS GEILGCT+P +  + + ++YLGDGRFHLE+VM+ANPN+ A+RYDPYSK ++RE YDH  MQ+NR  AI TAR AK++G+ILGTLGRQGS  +L+ + + +Q  GL  V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH   +L++
Sbjct:   30 NQIPAEILNNPQLQAAI-QVLPSNYNFEVPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLVPMDTSAQDFRVLYVFVDIRIDTAHLLDSIRLTFPPASALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPCLPKEVEAVVYLGDGRFHLESVMIANPNISAYRYDPYSKVLSREHYDHQRMQANRQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLQALGLPFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYASSSLGPWTVNHGRDRLLQ 400
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Match: sp|Q5NCQ5|DPH1_MOUSE (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Mus musculus OX=10090 GN=Dph1 PE=1 SV=1)

HSP 1 Score: 438.728 bits (1127), Expect = 1.034e-150
Identity = 220/427 (51.52%), Postives = 289/427 (67.68%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPETLVQ-----MPTVSRSGAPACAEHEWENCTNCTC 1318
            N+IP  ++NN  L  A+ Q+LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCLVP+D S    +  YVFV I ID  H +DSV + F  GS L LV+TIQF+STLQA   EL   + +++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPY K ++RE YDH  MQ+ R  AI  AR AK++G+ILGTLGRQGS  +L+ + + ++  GL  V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWG+ F KPLLTPYEAAVAL    W     YPMDFY+  SLG WT N+             G  + P  L Q     +   SR G+PA A      C +C C
Sbjct:   30 NQIPPEVLNNPQLQAAV-QVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPGSSLALVSTIQFVSTLQAAAQELKADYHISVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNIPAYRYDPYGKVLSREYYDHQRMQATRQEAIAAARSAKSWGLILGTLGRQGSPKILEHLESQLRNLGLPFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISW--QQPYPMDFYSGSSLGPWTVNY-------------GRDRAPRGLCQPASDKVQQGSRGGSPAPA------CESCNC 428
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Match: sp|Q9BZG8|DPH1_HUMAN (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=2)

HSP 1 Score: 437.187 bits (1123), Expect = 5.332e-150
Identity = 209/374 (55.88%), Postives = 274/374 (73.26%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS----KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVA-DADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN 1174
            N+IP  I+ N  L  AI ++LP NYNFEI KTI RI+   AK++ALQ+PEGL LFAC + DIL +F        ++++MGDVTYGACC+DD+T+RAL  D L+HYGHSCL+P+D S    +  YVFV I ID  H +DS+ + F   + L LV+TIQF+STLQA   EL  ++ V++P+  PLS GEILGCT+P ++ + + ++YLGDGRFHLE+VM+ANPN+PA+RYDPYSK ++RE YDH  MQ+ R  AI TAR AK++G+ILGTLGRQGS  +L+ + + ++  GL+ V +LLSE+FP+KL +  + +D ++Q+ACPRLSIDWGT F KPLLTPYEAAVAL    W     YPMDFYA  SLG WT NH 
Sbjct:   35 NQIPPEILKNPQLQAAI-RVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTE-----AEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPE-VDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISW--QQPYPMDFYAGSSLGPWTVNHG 399
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Match: sp|Q6GPQ5|DPH1_XENLA (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Xenopus laevis OX=8355 GN=dph1 PE=2 SV=2)

HSP 1 Score: 436.802 bits (1122), Expect = 5.544e-150
Identity = 209/391 (53.45%), Postives = 283/391 (72.38%), Query Frame = 2 
Query:   41 LNANKKSDR---NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADA-DFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR 1192
            +NA +   R   N+IPD I +N LL +A+ ++LP NYNFEI KTI RI+  +AKR+ALQ+PEGL +FAC ++DI+ +F        + ++MGDVTYGACC+DDYT++AL  D ++HYGHSCL+P+D +   +  YVFV I ID  HF+D++  NF  G+ L LV+T+QF+S LQA R  L   + VT+P+  PLS GEILGCT+P +  + D ++YLGDGRFHLE+VM++NP+  A+RYDPYSK  +RE YDHS M  +R  AI  A  AKT+G+ILGTLGRQGS  +++ + + +Q  G  +V +LLSE+FPNKL +F + ++ ++Q+ACPRLSIDWGT F KPLLTPYEA+VAL  A+W     YPMDFYA++SLG WT NH   +  R
Sbjct:   21 INAGRAPVRRVANQIPDEIAHNPLLLEAM-KVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACAIADIIERFTS-----AETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQAGASLALVSTVQFVSALQAARQALQTDYNVTVPQCKPLSPGEILGCTSPRLNKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSTMLRHRGEAISVATNAKTWGLILGTLGRQGSPKIMEHLESRLQALGCRYVRLLLSEIFPNKLKLFAE-VEVWVQVACPRLSIDWGTAFSKPLLTPYEASVALKEAEWQLT--YPMDFYANESLGPWTVNHESHRPTR 402
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Match: A0A0A1MWA0 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Rhizopus microsporus OX=58291 GN=BCV71DRAFT_214311 PE=3 SV=1)

HSP 1 Score: 483.411 bits (1243), Expect = 6.255e-166
Identity = 236/389 (60.67%), Postives = 295/389 (75.84%), Query Frame = 2 
Query:   56 KSDR--NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS--KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVV 1210
            +S+R  N++PD I+ + LLN+AIEQ+ P NYNFEIHKT+ R+R  NAKR+ALQLPEGL +FAC++SDIL  F   N+E    +IMGDVTYGACCIDDYT+RAL CD L+HYGHSCLVP+D +  +T YVFV I ID +HFID+V  NF+ G  L LV TIQF + LQA +  L + FTVTIP+S PLS GEILGCT+P + D D I+ +GDGRFHLE++++ NP+LPAF+Y+PY+K  TRE+YDH  M S R +AI TA+ AK +G+ILGTLGRQG   +L+ +   I+ +G + V +LLSE+FP KL+ F D +DA+IQIACPRLSIDWG  F KPLLTPYEA+VALG A W   D YPMDFYA+DSLG WTPNH      RR+  VV
Sbjct:   46 RSNRVANQVPDEILQDPLLNKAIEQI-PSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFC--NAE---TLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKASLEQDFTVTIPQSKPLSPGEILGCTSPKLTDTDVIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIRDQGKDSVNVLLSEIFPGKLEQF-DDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALGKADW--QDVYPMDFYANDSLGPWTPNHGRGVQGRRRQPVV 425
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Match: A0A1X0R8S8 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Rhizopus microsporus var. microsporus OX=86635 GN=BCV72DRAFT_323779 PE=3 SV=1)

HSP 1 Score: 480.715 bits (1236), Expect = 6.548e-165
Identity = 233/376 (61.97%), Postives = 291/376 (77.39%), Query Frame = 2 
Query:   56 KSDR--NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS--KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH 1171
            +S+R  N++PD I+ + LLN+AIEQ+ P NYNFEIHKT+ R+R  NAKR+ALQLPEGL +FAC++SDIL  F   N+E    +IMGDVTYGACCIDDYT+RAL CD L+HYGHSCLVP+D +  +T YVFV I ID +HFID+V  NF+ G  L LV TIQF + LQA +T L + FTVTIP+S PLS GEILGCT+P + D D I+ +GDGRFHLE++++ NP+LPAF+Y+PY+K  TRE+YDH  M S R +AI TA+ AK +G+ILGTLGRQG   +L+ +   I+ +G + V +LLSE+FP KL+ F D +DA+IQIACPRLSIDWG  F KPLLTPYEA+VALG A W   D YPMDFYA+DSLG WTPNH
Sbjct:   46 RSNRVANQVPDEILQDPLLNKAIEQI-PSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFC--NAE---TLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKTSLEQDFTVTIPQSKPLSPGEILGCTSPKLTDTDAIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIKDQGKDSVNVLLSEIFPGKLEQF-DDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALGKADW--QDVYPMDFYANDSLGPWTPNH 412
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Match: A0A0C7B0B8 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Rhizopus microsporus OX=58291 GN=RMATCC62417_01411 PE=3 SV=1)

HSP 1 Score: 480.715 bits (1236), Expect = 6.548e-165
Identity = 233/376 (61.97%), Postives = 291/376 (77.39%), Query Frame = 2 
Query:   56 KSDR--NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS--KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH 1171
            +S+R  N++PD I+ + LLN+AIEQ+ P NYNFEIHKT+ R+R  NAKR+ALQLPEGL +FAC++SDIL  F   N+E    +IMGDVTYGACCIDDYT+RAL CD L+HYGHSCLVP+D +  +T YVFV I ID +HFID+V  NF+ G  L LV TIQF + LQA +T L + FTVTIP+S PLS GEILGCT+P + D D I+ +GDGRFHLE++++ NP+LPAF+Y+PY+K  TRE+YDH  M S R +AI TA+ AK +G+ILGTLGRQG   +L+ +   I+ +G + V +LLSE+FP KL+ F D +DA+IQIACPRLSIDWG  F KPLLTPYEA+VALG A W   D YPMDFYA+DSLG WTPNH
Sbjct:   46 RSNRVANQVPDEILQDPLLNKAIEQI-PSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFC--NAE---TLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKTSLEQDFTVTIPQSKPLSPGEILGCTSPKLTDTDAIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIKDQGKDSVNVLLSEIFPGKLEQF-DDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALGKADW--QDVYPMDFYANDSLGPWTPNH 412
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Match: A0A2G4SQS5 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Rhizopus microsporus ATCC 52813 OX=1340429 GN=RHIMIDRAFT_285453 PE=3 SV=1)

HSP 1 Score: 480.33 bits (1235), Expect = 9.010e-165
Identity = 233/376 (61.97%), Postives = 291/376 (77.39%), Query Frame = 2 
Query:   56 KSDR--NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS--KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH 1171
            +S+R  N++PD I+ + LLN+AIEQ+ P NYNFEIHKT+ R+R  NAKR+ALQLPEGL +FAC++SDIL  F   N+E    +IMGDVTYGACCIDDYT+RAL CD L+HYGHSCLVP+D +  +T YVFV I ID +HFID+V  NF+ G  L LV TIQF + LQA +T L + FTVTIP+S PLS GEILGCT+P + D D I+ +GDGRFHLE++++ NP+LPAF+Y+PY+K  TRE+YDH  M S R +AI TA+ AK +G+ILGTLGRQG   +L+ +   I+ +G + V +LLSE+FP KL+ F D +DA+IQIACPRLSIDWG  F KPLLTPYEA+VALG A W   D YPMDFYA+DSLG WTPNH
Sbjct:   42 RSNRVANQVPDEILQDPLLNKAIEQI-PSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFC--NAE---TLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKTSLEQDFTVTIPQSKPLSPGEILGCTSPKLTDTDAIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIKDQGKDSVNVLLSEIFPGKLEQF-DDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALGKADW--QDVYPMDFYANDSLGPWTPNH 408
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Match: A0A0A1NJ28 (2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Rhizopus microsporus OX=58291 GN=RMCBS344292_06009 PE=3 SV=1)

HSP 1 Score: 478.019 bits (1229), Expect = 7.463e-164
Identity = 232/376 (61.70%), Postives = 290/376 (77.13%), Query Frame = 2 
Query:   56 KSDR--NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS--KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH 1171
            +S+R  N++PD I+ + LLN+AIEQ+ P NYNFEIHKT+ R+R  NAKR+ALQLPEGL +FAC++SDIL  F   N+E    +IMGDVTYGACCIDDYT+RAL CD L+HYGHSCLVP+D +  +T YVFV I ID +HFID+V  NF+ G  L LV TIQF + LQA +T L + FTVTIP+S PLS GEILGCT+P +   D I+ +GDGRFHLE++++ NP+LPAF+Y+PY+K  TRE+YDH  M S R +AI TA+ AK +G+ILGTLGRQG   +L+ +   I+ +G + V +LLSE+FP KL+ F D +DA+IQIACPRLSIDWG  F KPLLTPYEA+VALG A W   D YPMDFYA+DSLG WTPNH
Sbjct:   46 RSNRVANQVPDEILQDPLLNKAIEQI-PSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFC--NAE---TLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKTSLEQDFTVTIPQSKPLSPGEILGCTSPKLTGTDAIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIKDQGKDSVNVLLSEIFPGKLEQF-DDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALGKADW--QDVYPMDFYANDSLGPWTPNH 412
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Cavefish
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:550559])

HSP 1 Score: 437.573 bits (1124), Expect = 1.846e-151
Identity = 208/384 (54.17%), Postives = 279/384 (72.66%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH---NPAKLIRRK 1198
            N+IP+ I+ +  L  AI  +LP NYNFEIHKT+ R+R   AKR+ALQLPEGLQ+FACV++DI+ +F        D ++MGDVTYGACC+DD+T+RAL  D ++HYGHSCL+P+D +   K  YVFV I +D  HF+D++  NF  G  L LV+TIQF+S LQAV  EL   + V +P+  PLS GEILGCT+P +    + I+YLGDGRFHLE++M+ANP++PA+RYDPY+K  +RE YDH  M++NRL AI  AR A+ +G+ILGTLGRQG+  +L+ +   ++  G +   +LLSE+FP+KL +  D +DA++QIACPRLSIDWGT F KPLL+PYEAAVAL   +W   + YPMDFY++ SLG W PNH    P +  R++
Sbjct:   38 NQIPEEILKDPELQDAIS-VLPANYNFEIHKTVWRVRQAKAKRVALQLPEGLQMFACVIADIIERFT-----GADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTAGIKMLYVFVDIQMDTAHFLDTLRFNFPQGHSLALVSTIQFVSALQAVSAELKPDYEVLVPQCRPLSPGEILGCTSPRLDKHVNAIIYLGDGRFHLESIMIANPDIPAYRYDPYNKVFSREHYDHEAMRANRLQAIEKARSAQRWGLILGTLGRQGNPKILEHLENKLEALGRSFTRVLLSEIFPSKLALMAD-VDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQKVEW--QEVYPMDFYSNQSLGPWAPNHPDNQPKRPTRKQ 412
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Cavefish
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:550559])

HSP 1 Score: 362.459 bits (929), Expect = 6.039e-123
Identity = 169/311 (54.34%), Postives = 227/311 (72.99%), Query Frame = 2 
Query:  287 VDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH---NPAKLIRRK 1198
             D ++MGDVTYGACC+DD+T+RAL  D ++HYGHSCL+P+D +   K  YVFV I +D  HF+D++  NF  G  L LV+TIQF+S LQAV  EL   + V +P+  PLS GEILGCT+P +    + I+YLGDGRFHLE++M+ANP++PA+RYDPY+K  +RE YDH  M++NRL AI  AR A+ +G+ILGTLGRQG+  +L+ +   ++  G +   +LLSE+FP+KL +  D +DA++QIACPRLSIDWGT F KPLL+PYEAAVAL   +W   + YPMDFY++ SLG W PNH    P +  R++
Sbjct:   23 ADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTAGIKMLYVFVDIQMDTAHFLDTLRFNFPQGHSLALVSTIQFVSALQAVSAELKPDYEVLVPQCRPLSPGEILGCTSPRLDKHVNAIIYLGDGRFHLESIMIANPDIPAYRYDPYNKVFSREHYDHEAMRANRLQAIEKARSAQRWGLILGTLGRQGNPKILEHLENKLEALGRSFTRVLLSEIFPSKLALMAD-VDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQKVEW--QEVYPMDFYSNQSLGPWAPNHPDNQPKRPTRKQ 330
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Cavefish
Match: dph2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:103024134])

HSP 1 Score: 96.6709 bits (239), Expect = 3.519e-21
Identity = 88/359 (24.51%), Postives = 155/359 (43.18%), Query Frame = 2 
Query:  146 FEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNF-DDGSHLVLVATIQFISTLQAVRTELSKK-----FTVTIPKSAP--------LSFGEILGCTAPTVAD--------------ADF-ILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGI-AQWMPNDHYPMDF 1132
            ++I  T   I+    K++ALQ P+ L + A  +S      A E    V   I+GD +YG+CC+D+  +  +  D ++HYG SCL P       YVF    +D++   ++    + +  S +V++ ++ +   +   R  +        F+V  P+ +         LS G+   C    V                 D+ + Y+G     L   MM         +DP +     E  + +     R  AI  A+ A   GI++GTLG      ++D +   I++ G    +  + ++   KL  F + ID ++ +ACP  S+   + F +P++TP+E  VA     +W  +  Y  DF
Sbjct:   35 YQISDTCHFIQSKGFKKVALQFPDELLVDAVGVS-----AAIEKETNVKTYILGDTSYGSCCVDEVAAEHVGADCIVHYGRSCLSPSRRLPLMYVFGKRPMDVQKCAETFRELYPESDSCVVVLYSVIYAHAIDDCRKLIGASYPNTVFSVLRPECSDGQEQVYGLLSDGDHSDCLGDRVVKKLGRYFRLKEGKSVEDYSMFYIGHEGLTLTNFMMTWNRCAFSSFDPETSTGRTESININKALMKRYYAIERAKDASVVGILVGTLGVANYLTIIDQLKESIRKAGKKSYMFAMGKINVAKLANFLE-IDVYVLVACPENSLLDSSEFYRPVVTPFEMEVACNKHREW--SGEYVTDF 385
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000442.1 (pep scaffold:Pmarinus_7.0:GL480751:2537:8520:1 gene:ENSPMAG00000000397.1 transcript:ENSPMAT00000000442.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 97.8265 bits (242), Expect = 2.455e-25
Identity = 47/84 (55.95%), Postives = 60/84 (71.43%), Query Frame = 2 
Query:  731 RYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGD 982
            RYDPYSK  TRE+YDH  M++ R +AI  A KAKT+G+ILGTLGRQGS  ++  V   +Q+ G   V +LLSE+FP KL +F D
Sbjct:    1 RYDPYSKMFTREEYDHGAMRAARKDAIAEAAKAKTWGLILGTLGRQGSPKIMQHVEDSLQRAGRKCVRLLLSEIFPCKLRLFQD 84
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Sea Lamprey
Match: dph2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:562538])

HSP 1 Score: 73.9442 bits (180), Expect = 5.155e-15
Identity = 50/160 (31.25%), Postives = 79/160 (49.38%), Query Frame = 2 
Query:  608 FGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLS-IDWGTFFQKPLLTPYEAAVA 1084
            FG +L   A +  +   + Y+G     L   MM+  N   F YDP S E  R     S +   R   +  AR A + GI++GTLG  G   +++ +   + + G    + ++ +  P KL  F + ID F+ +ACP  S +D   F+Q P++TP+E  VA
Sbjct:    1 FGRLLLVEAGSRLEDYSVFYIGRESITLTNFMMSWNNCEFFTYDPESGESQRASASTSRLVKRRYYLVERARDAGSVGILVGTLGVAGFLEIIEQLKRALARAGKRWQVFVVGKPNPAKLANFPE-IDVFVLVACPENSLLDCAEFYQ-PIVTPFEMEVA 158
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Yeast
Match: DPH1 (Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p [Source:SGD;Acc:S000001365])

HSP 1 Score: 375.555 bits (963), Expect = 6.379e-128
Identity = 189/377 (50.13%), Postives = 250/377 (66.31%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSK--TFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTEL----SKKFTVTIPKSAPLSFGEILGCTAPTV--ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKW-TPNH 1171
            N +P++I+N+  LN+AI +LLP NYNFEIHKT+  IR  NAKRIALQ+PEGL +++ ++SDIL +F       V+ ++MGDV+YGACCIDD+T+RALDCD ++HY HSCLVP+D +K    YVFV INI   H I ++  NF  GS +    TIQF   + +VR +L         +  P+  PLS GE+LGCT+  +     D ++++GDGRFHLE+ M+ NP +PAF+YDPY+++ TRE YD   +   R  AI  ARK K FG+ILG LGRQG+   + ++   +   G   V I+LSEVFP KL MF D ID F+Q+ACPRLSIDWG  F KPLLTPYEA+V L         +YPMD+Y     G+  TP H
Sbjct:   53 NHVPEDILNDKELNEAI-KLLPSNYNFEIHKTVWNIRKYNAKRIALQMPEGLLIYSLIISDILEQFC-----GVETLVMGDVSYGACCIDDFTARALDCDFIVHYAHSCLVPIDVTKIKVLYVFVTINIQEDHIIKTLQKNFPKGSRIATFGTIQFNPAVHSVRDKLLNDEEHMLYIIPPQIKPLSRGEVLGCTSERLDKEQYDAMVFIGDGRFHLESAMIHNPEIPAFKYDPYNRKFTREGYDQKQLVEVRAEAIEVARKGKVFGLILGALGRQGNLNTVKNLEKNLIAAGKTVVKIILSEVFPQKLAMF-DQIDVFVQVACPRLSIDWGYAFNKPLLTPYEASVLLKKDVMFSEKYYPMDYYEAKGYGRGETPKH 422
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Yeast
Match: DPH2 (Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p [Source:SGD;Acc:S000001674])

HSP 1 Score: 69.707 bits (169), Expect = 2.968e-13
Identity = 79/352 (22.44%), Postives = 143/352 (40.62%), Query Frame = 2 
Query:  191 KRIALQLPEGLQLFACVLSDIL-SKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDD-GSHLVLVATIQFISTL-------------------QAVRTELSKKF-----TVTIPKSA---------PLSFGEILGCTAPTVADADFILYLGDGRFHL---------------EAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSI--DWGTFFQKPLLTPYEAAVALG 1090
            + + LQ P+ L   + ++  +L SKF +   +F    ++ D  Y ACC+D+  +  +  ++++H+G +CL  +      Y F    +D+   +++    F D  S + L+A   F   L                   Q   + + +KF     T  +P+            + FG+     A  ++  D+ L      FHL               ++V + +P LP     P+   + R KY H             AR A   GI++ TL  + +   ++ ++  I+ R   H + ++ +    KL  F D ID +  + C +  I  D    F KP++TPYE  +AL 
Sbjct:   63 QNVTLQFPDDLIKDSSLIVRLLQSKFPHGKIKF---WVLADTAYSACCVDEVAAEHVHAEVVVHFGDACLNAIQNLPVVYSFGTPFLDLALVVENFQRAFPDLSSKICLMANAPFSKHLSQLYNILKGDLHYTNIIYSQVNTSAVEEKFVTILDTFHVPEDVDQVGVFEKNSVLFGQ--HDKADNISPEDYHL------FHLTTPQDPRLLYLSTVFQSVHIFDPALPGMVTGPFPSLMRRYKYMH------------VARTAGCIGILVNTLSLRNTRETINELVKLIKTREKKHYLFVVGKPNVAKLANFED-IDIWCILGCSQSGIIVDQFNEFYKPIITPYELNLALS 390
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Nematostella
Match: DPH1 (Diphthamide biosynthesis protein 1 [Source:UniProtKB/Swiss-Prot;Acc:A7SLX5])

HSP 1 Score: 443.351 bits (1139), Expect = 1.608e-153
Identity = 226/422 (53.55%), Postives = 282/422 (66.82%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHN---PAKLIRRKHIVVGEKKMPETLVQMPTVSRSGAPACAEHEWENCTNCT 1315
            N+IP+ I+ +  L +A    LP NYNFEIHKTI RI+ + AKR+ALQ PEGL LFAC ++DIL  F        + +IMGDVTYGACC+DDY++RAL CDLL+HYGHSCLVP+D +   K  YVFV I ID  HF++SV  N   GS L LV+TIQF++ LQA   ELSK + V IP+  PLS GEILGCTAP + D D ++YLGDGRFHLEAVM+ANP + A+RYDPY K  ++E YD   M   R  AI  A  A  +G+ILGTLGRQGS  VL ++   +Q   ++++I+LLSEVFP+KL +F D +DA++Q+ACPRLSIDWGT F KPLL+PYEA+VAL    W     YPMDFYA+ SLG WTPN+    P    RRK  +  E  +       P +  S    C   E   C  CT
Sbjct:   50 NQIPEEILKDTKLQEA----LPENYNFEIHKTIWRIQQVKAKRVALQFPEGLLLFACTIADILESFT-----GCETVIMGDVTYGACCVDDYSARALGCDLLVHYGHSCLVPIDATAGIKMLYVFVDIKIDTAHFVESVRFNLGAGSCLALVSTIQFVAALQAASNELSKDYQVEIPQCKPLSPGEILGCTAPMLKDKDAVIYLGDGRFHLEAVMIANPAIQAYRYDPYDKTFSKEYYDIDKMHEARQTAIKQASLASKYGLILGTLGRQGSPKVLQTLEKQLQSLNMDYIIVLLSEVFPDKLKLFKD-VDAWVQVACPRLSIDWGTAFPKPLLSPYEASVALQSVAW--QQSYPMDFYAYSSLGGWTPNNESNRPTPANRRKKNLHTEVIIDNVSDSKPVIKES---ECGSGE-TCCGKCT 455
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Nematostella
Match: DPH2 (Diphthamide biosynthesis protein 2 [Source:UniProtKB/Swiss-Prot;Acc:A7SKJ3])

HSP 1 Score: 89.7373 bits (221), Expect = 2.976e-19
Identity = 96/429 (22.38%), Postives = 183/429 (42.66%), Query Frame = 2 
Query:  110 QAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYG------------------------------ACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDI----KHFID-------SVMVNFDDGSHLVLVATIQFISTL-----------QAVRTELSKKFTVTIPKSAPLSFGEILGCT---------APTVADADF-ILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVA-LGIAQWMPNDHYPMDFYAHDSL-GK-----WTPNHNPAKLI 1189
            ++IE+++ +   +EI +++  I      ++ALQ P+ L   +  ++ ++ + A          I+ D +YG                              +CC+D+  +   D +L+IHYG +CL         YVF    I++    +HF          V+V +D   +  + A  + +S L           + + +E + + +   P+++ +   E+  C          A   + +D+ I Y+G+    L  +MM         YDP + E  RE  + +     R + I  A+ A+  GI++GTLG      +++ +   +   G    + ++ ++   KL  F + ID F+ ++CP  S+     F KP++TPYE  +A L   +W  +  Y  DF  H+ L GK     WT +++ +  I
Sbjct:   35 ESIERMVEV---YEIERSVQVITSSGFNKVALQFPDSLLADSASVARLIEQRAS-----CKAFILADTSYGRHPPLPANKTFLKLYNVRICFKLLAFLHFSSCCVDEIAAEHADAELIIHYGQACLSQTKRLPVLYVFGKNPINVIECSQHFRQLYPDTGIRVLVFYDVVYNHCIGALDEALSPLYPNMTISTIAPEGLPSEPTSQQSSRNPQASDVEGMEVNQCNRRFGRDFTLAANSSISDYQIFYIGEQSLTLRNLMMTYNKCQFSTYDPITNESRRETLNVNKALMKRYHMIQRAKDAQIVGIVVGTLGVADYLKIIERLKKVLAIAGKKSYVFVMGKLNVAKLANFLE-IDVFVLVSCPENSLIDSKEFYKPVVTPYEMEIACLRTQEWTGD--YVTDF--HELLPGKSINTFWTDDNDDSPYI 450
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Medaka
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:101164330])

HSP 1 Score: 438.728 bits (1127), Expect = 3.851e-152
Identity = 211/384 (54.95%), Postives = 279/384 (72.66%), Query Frame = 2 
Query:   68 NKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNH---NPAKLIRRK 1198
            N+IP++I+ +  L  A++ L P NYNFEIHKT+ R+R  NAKR+ALQLPEGLQ+FAC ++DI+ +F        D I+MGDVTYGACC+DD+T+RAL  D ++HYGHSCL+P+D     K  YVFV I +D  HF+D+V  NF  G  L LV+TIQF++ LQAV + L  ++ V +P+  PLS GEILGCT+P +    D ++YLGDGRFHLE++M+ANP++PA+RYDPYSK  +RE YDH  M++ RL AI  AR A+ +G+ILGTLGRQGS  VL+ + + +Q  G +   +LLSE+FP+KLD+  D +DA++QIACPRLSIDWGT F KPLL+PYEAAVAL    W   + YPMDFY++ S G W PNH    P +  RR+
Sbjct:   21 NQIPNDILQDPELQDAMKAL-PSNYNFEIHKTVWRVRQANAKRVALQLPEGLQMFACTIADIIERFTE-----ADTIVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSMAGIKMLYVFVDIQMDNVHFLDTVKFNFSPGQSLALVSTIQFVAALQAVSSALKPQYDVIVPQCRPLSPGEILGCTSPRLDRHVDALIYLGDGRFHLESIMIANPDIPAYRYDPYSKVFSREYYDHEAMRALRLQAIAEARLAQRWGLILGTLGRQGSPKVLEHLESRLQSVGKSFTRVLLSEIFPSKLDLMAD-VDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQEVDW--KEVYPMDFYSNQSSGPWAPNHPDNQPVRPARRQ 395
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Medaka
Match: dph1 (diphthamide biosynthesis 1 [Source:NCBI gene;Acc:101164330])

HSP 1 Score: 374.4 bits (960), Expect = 1.127e-127
Identity = 181/345 (52.46%), Postives = 242/345 (70.14%), Query Frame = 2 
Query:  227 LFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCS---KTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTV-ADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIR--RKHIVVGEKKMPETLVQ 1243
            +FAC ++DI+ +F        D I+MGDVTYGACC+DD+T+RAL  D ++HYGHSCL+P+D     K  YVFV I +D  HF+D+V  NF  G  L LV+TIQF++ LQAV + L  ++ V +P+  PLS GEILGCT+P +    D ++YLGDGRFHLE++M+ANP++PA+RYDPYSK  +RE YDH  M++ RL AI  AR A+ +G+ILGTLGRQGS  VL+ + + +Q  G +   +LLSE+FP+KLD+  D +DA++QIACPRLSIDWGT F KPLL+PYEAAVAL    W   + YPMDFY++ S G W PNH   + +R  R+     E K P   ++
Sbjct:    1 MFACTIADIIERFTE-----ADTIVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSMAGIKMLYVFVDIQMDNVHFLDTVKFNFSPGQSLALVSTIQFVAALQAVSSALKPQYDVIVPQCRPLSPGEILGCTSPRLDRHVDALIYLGDGRFHLESIMIANPDIPAYRYDPYSKVFSREYYDHEAMRALRLQAIAEARLAQRWGLILGTLGRQGSPKVLEHLESRLQSVGKSFTRVLLSEIFPSKLDLMAD-VDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQEVDW--KEVYPMDFYSNQSSGPWAPNHPDNQPVRPARRQTQQKESKEPSPPIK 337
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Medaka
Match: dph2 (diphthamide biosynthesis 2 [Source:NCBI gene;Acc:101167249])

HSP 1 Score: 93.2041 bits (230), Expect = 4.100e-20
Identity = 88/360 (24.44%), Postives = 152/360 (42.22%), Query Frame = 2 
Query:  146 FEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNF-DDGSHLVLVATIQF------------------ISTLQAVRTE----------LSKKFTVTIPKSAPLSFGEILGCTAPTVADADF-ILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIA-QWMPNDHYPMDF 1132
            +EI K    I   + +++ALQ P+ L   +  +++ + K        V   I+GD +YG+CC+D+  +  +  D ++HYG +CL P       Y+F    +D++    S    + D  SH+VL+  + +                  +++   V +E          LS   +    K     FG    C    +   D+ + Y+G     L   MM         +DP  ++   E    +     R  AI  A+ A   GI++GTLG      ++  +   I + G    +  + ++   KL  F + ID F+ IACP  S+   + F KP++TP+E  VA     +W  ++ Y  DF
Sbjct:   34 YEIKKCCKFITDHHFQKVALQFPDELLRDSVAVAEEIEKNCN-----VKTFILGDTSYGSCCVDEVAAEHVGADCIVHYGSACLSPSKRLPLMYIFEKRQLDVEMCACSFRELYPDKQSHVVLLYDVNYDHAIDDLVRILSPEYPNLLASKLVVESEQCFSHDRTDQLSSLLSDHDEKQLVYQFGRQF-CLKTGLTITDYSMFYVGQEGATLRNFMMTWNRCSFCSFDPEKRKGRVESISINRALMKRYYAIERAKDASVVGILVGTLGVADYLTIIQQLKENIHRAGKKSYVFAMGKLNVPKLANFLE-IDIFVLIACPENSLLDSSEFYKPVVTPFEMEVACNRKREW--SEEYVTDF 384
[Close]
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Planmine SMEST
Match: SMESG000039807.1 (SMESG000039807.1)

HSP 1 Score: 896.73 bits (2316), Expect = 0.000e+0
Identity = 429/431 (99.54%), Postives = 431/431 (100.00%), Query Frame = 2 
Query:   35 MTLNANKKSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVALGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPETLVQMPTVSRSGAPACAEHEWENCTNCTCMHN 1327
            MTLNANKKSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFF+KPLLTPYEAAVALGIA+WMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPETLVQMPTVSRSGAPACAEHEWENCTNCTCMHN
Sbjct:    1 MTLNANKKSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTAPTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFKKPLLTPYEAAVALGIAKWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPETLVQMPTVSRSGAPACAEHEWENCTNCTCMHN 431
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Planmine SMEST
Match: SMESG000022748.1 (SMESG000022748.1)

HSP 1 Score: 79.337 bits (194), Expect = 1.019e-15
Identity = 95/366 (25.96%), Postives = 161/366 (43.99%), Query Frame = 2 
Query:   80 DNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVLNAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCIDDYTSRALDCDLLIHYGHSCL------VPLDCSKTFYVFVYINID-----IKHFIDSVMVNFDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLS-------------FGEILGCTAPTVADADFILYLGDG-RFHLEAVMMANPNL--PAFRYDPYSKEITREKYDHSLMQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVIILLSEVFPNKLDMFGDSIDAFIQI----ACPRLSIDWGTFFQKPLLTPYEAAVA 1084
            D+I NN L   +IE       NFEI +T   I   N K++ LQ P+ L   A  +S  L K    N +F    IM D +YG+CCID+        D ++HYG++CL      VP       Y+     ++     IK  ++SV  N      + +V    +I   ++V  +L     +       LS             FG  L  +     + + IL++GD   +  + ++++  +L      Y P +KEI     +      +RL +I  A+ A   G+++GTL  +    + + +   +++ G     +++ ++  NKL  F D +DA + I    +C + S     +F KP++TPYE   A
Sbjct:   19 DSIYNNSL---SIE-------NFEIQETSKWINDNNFKKVGLQFPDELLKIAIPISLELKKTV--NCQFG---IMADTSYGSCCIDEVGGEHFSVDAIVHYGNACLSLTHRKVPSKFVFGKYMVNETEVETSVEIIKFHLNSVFKNEILKKCITVVYDFPYIHFCKSVEDKLKNVDFIVFNSFPNLSEYNYNLSVDEYKLFGSRLVQSNDNNDNENIILFIGDRYNYSTKTILLSMYHLYKTILLYSPKTKEIRDVSNEIQKFLRSRLYSIEVAKSAIRVGLLVGTLSIENYLEIYNYLYDTMRKSGKIVYPMVVGKINANKLANFAD-LDALVVINCADSCLQFSEKKDDYF-KPVVTPYEMICA 367
The following BLAST results are available for this feature:
BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DPH11.110e-15055.88diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc... [more]
DPH14.756e-13553.48diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc... [more]
DPH12.129e-13255.36diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc... [more]
DPH16.977e-3354.78diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc... [more]
DPH13.242e-2163.77diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dph-15.085e-13950.632-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
dph-24.414e-1323.312-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Dph12.432e-14955.70gene:FBgn0036194 transcript:FBtr0076131[more]
Dph12.432e-14955.70gene:FBgn0036194 transcript:FBtr0332766[more]
Dph12.432e-14955.70gene:FBgn0036194 transcript:FBtr0076130[more]
CG72655.708e-1422.22gene:FBgn0038272 transcript:FBtr0083009[more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
dph16.889e-11352.72diphthamide biosynthesis 1 [Source:NCBI gene;Acc:5... [more]
dph12.939e-2157.75diphthamide biosynthesis 1 [Source:NCBI gene;Acc:5... [more]
dph22.555e-1924.20diphthamide biosynthesis 2 [Source:NCBI gene;Acc:5... [more]
dph24.556e-929.37diphthamide biosynthesis 2 [Source:NCBI gene;Acc:5... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cenpj6.684e-14954.09centromere protein J [Source:Xenbase;Acc:XB-GENE-1... [more]
cenpj1.034e-14854.09centromere protein J [Source:Xenbase;Acc:XB-GENE-1... [more]
cenpj1.569e-14754.09centromere protein J [Source:Xenbase;Acc:XB-GENE-1... [more]
cenpj4.501e-14454.29centromere protein J [Source:Xenbase;Acc:XB-GENE-1... [more]
DPH24.282e-2624.10diphthamide biosynthesis 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Dph11.479e-15151.52diphthamide biosynthesis 1 [Source:MGI Symbol;Acc:... [more]
Dph11.080e-10455.64diphthamide biosynthesis 1 [Source:MGI Symbol;Acc:... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A7SLX5|DPH1_NEMVE3.924e-15253.552-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
sp|Q3SYT1|DPH1_BOVIN6.939e-15256.322-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
sp|Q5NCQ5|DPH1_MOUSE1.034e-15051.522-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
sp|Q9BZG8|DPH1_HUMAN5.332e-15055.882-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
sp|Q6GPQ5|DPH1_XENLA5.544e-15053.452-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0A1MWA06.255e-16660.672-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
A0A1X0R8S86.548e-16561.972-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
A0A0C7B0B86.548e-16561.972-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
A0A2G4SQS59.010e-16561.972-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
A0A0A1NJ287.463e-16461.702-(3-amino-3-carboxypropyl)histidine synthase subu... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dph11.846e-15154.17diphthamide biosynthesis 1 [Source:NCBI gene;Acc:5... [more]
dph16.039e-12354.34diphthamide biosynthesis 1 [Source:NCBI gene;Acc:5... [more]
dph23.519e-2124.51diphthamide biosynthesis 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000000442.12.455e-2555.95pep scaffold:Pmarinus_7.0:GL480751:2537:8520:1 gen... [more]
dph25.155e-1531.25diphthamide biosynthesis 2 [Source:NCBI gene;Acc:5... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
DPH16.379e-12850.13Protein required for synthesis of diphthamide; req... [more]
DPH22.968e-1322.44Protein required for synthesis of diphthamide; req... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
DPH11.608e-15353.55Diphthamide biosynthesis protein 1 [Source:UniPro... [more]
DPH22.976e-1922.38Diphthamide biosynthesis protein 2 [Source:UniPro... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dph13.851e-15254.95diphthamide biosynthesis 1 [Source:NCBI gene;Acc:1... [more]
dph11.127e-12752.46diphthamide biosynthesis 1 [Source:NCBI gene;Acc:1... [more]
dph24.100e-2024.44diphthamide biosynthesis 2 [Source:NCBI gene;Acc:1... [more]
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BLAST of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000039807.10.000e+099.54SMESG000039807.1[more]
SMESG000022748.11.019e-1525.96SMESG000022748.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004597 ID=SMED30004597|Name=2-(3-amino-3-carboxypropyl)histidine synthase subunit 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1355bp
ATAATTTGATGTGTATTTAAATAAAAATCTTAGCATGACATTAAATGCAA
ATAAAAAAAGTGATCGCAATAAGATCCCAGATAATATTATTAATAATGTC
CTATTAAATCAAGCTATCGAACAACTATTACCAATTAATTATAATTTTGA
AATTCATAAAACTATTGCAAGAATTCGAGTTTTGAATGCTAAGCGGATTG
CGTTACAACTTCCCGAAGGTCTTCAATTATTTGCTTGTGTGTTATCAGAT
ATATTGTCAAAATTTGCATATGAAAATTCTGAGTTCGTAGACATAATTAT
TATGGGAGATGTGACATATGGTGCATGTTGTATCGATGATTACACTTCAC
GAGCTTTAGATTGTGATTTATTAATTCATTATGGTCATAGTTGTTTAGTC
CCACTTGATTGTTCAAAAACATTTTATGTCTTCGTTTATATAAATATTGA
TATCAAGCATTTTATCGATTCTGTAATGGTGAATTTTGATGATGGTTCTC
ATTTGGTATTAGTCGCAACAATTCAGTTTATTTCTACATTACAAGCTGTA
AGAACAGAATTATCTAAAAAGTTCACTGTAACGATTCCAAAATCTGCACC
ATTATCATTTGGTGAAATTCTCGGTTGTACAGCCCCTACGGTAGCAGACG
CCGATTTCATTTTATACCTCGGTGATGGCCGTTTCCACCTTGAAGCTGTT
ATGATGGCAAATCCCAATTTACCTGCATTCAGGTACGATCCATATTCAAA
AGAAATTACCCGGGAAAAATACGACCATTCTTTGATGCAGTCAAATCGAT
TAAATGCAATTGTAACAGCTAGAAAAGCAAAAACTTTCGGAATAATTTTG
GGCACTCTTGGTCGCCAAGGTTCTTCGGCAGTGCTCGATTCTGTCATTGC
TTGCATTCAACAAAGAGGATTAAATCACGTCATCATATTGCTGTCGGAGG
TCTTCCCAAATAAATTGGACATGTTCGGTGATTCCATCGATGCTTTTATT
CAGATCGCCTGTCCTCGTTTATCCATCGATTGGGGAACATTTTTTCAGAA
ACCTTTACTGACTCCTTATGAAGCTGCGGTCGCGTTGGGTATCGCTCAAT
GGATGCCCAATGATCACTACCCGATGGATTTCTATGCACACGACAGTCTC
GGTAAATGGACTCCCAATCACAATCCCGCTAAGCTCATCAGAAGGAAACA
CATTGTCGTTGGCGAGAAGAAGATGCCGGAGACATTGGTGCAAATGCCGA
CAGTGAGCAGATCTGGGGCTCCGGCATGTGCCGAGCACGAATGGGAGAAT
TGTACCAATTGTACTTGCATGCATAATTAATTAAATTTTCTGATTTCTCT
TTATT
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protein sequence of SMED30004597-orf-1

>SMED30004597-orf-1 ID=SMED30004597-orf-1|Name=SMED30004597-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=432bp
MTLNANKKSDRNKIPDNIINNVLLNQAIEQLLPINYNFEIHKTIARIRVL
NAKRIALQLPEGLQLFACVLSDILSKFAYENSEFVDIIIMGDVTYGACCI
DDYTSRALDCDLLIHYGHSCLVPLDCSKTFYVFVYINIDIKHFIDSVMVN
FDDGSHLVLVATIQFISTLQAVRTELSKKFTVTIPKSAPLSFGEILGCTA
PTVADADFILYLGDGRFHLEAVMMANPNLPAFRYDPYSKEITREKYDHSL
MQSNRLNAIVTARKAKTFGIILGTLGRQGSSAVLDSVIACIQQRGLNHVI
ILLSEVFPNKLDMFGDSIDAFIQIACPRLSIDWGTFFQKPLLTPYEAAVA
LGIAQWMPNDHYPMDFYAHDSLGKWTPNHNPAKLIRRKHIVVGEKKMPET
LVQMPTVSRSGAPACAEHEWENCTNCTCMHN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016740transferase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR035435DPH1/DPH2_euk_archaea
IPR042263DPH1/DPH2_1
IPR042264DPH1/DPH2_2
IPR042265DPH1/DPH2_3
IPR016435DPH1/DPH2
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0005886plasma membrane
GO:0016020membrane
Vocabulary: biological process
TermDefinition
GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR035435Diphthamide synthesis DHP1/DPH2, eukaryotes and archaeaPIRSFPIRSF004967DPH1coord: 18..384
e-value: 2.1E-128
score: 425.8
IPR042263Diphthamide synthesis DPH1/DPH2, domain 1GENE3DG3DSA:3.40.50.11840coord: 51..134
e-value: 1.2E-105
score: 355.2
IPR016435Diphthamide synthesis DPH1/DPH2PFAMPF01866Diphthamide_syncoord: 59..357
e-value: 1.4E-108
score: 363.0
IPR016435Diphthamide synthesis DPH1/DPH2TIGRFAMTIGR00322TIGR00322coord: 36..351
e-value: 1.5E-104
score: 347.8
IPR016435Diphthamide synthesis DPH1/DPH2SFLDSFLDS00032Radical_SAM_3-amino-3-carboxycoord: 26..392
e-value: 0.0
score: 327.1
IPR016435Diphthamide synthesis DPH1/DPH2PANTHERPTHR10762DIPHTHAMIDE BIOSYNTHESIS PROTEINcoord: 5..386
IPR042264Diphthamide synthesis DPH1/DPH2, domain 2GENE3DG3DSA:3.40.50.11850coord: 135..247
e-value: 1.2E-105
score: 355.2
IPR042265Diphthamide synthesis DPH1/DPH2, domain 3GENE3DG3DSA:3.40.50.11860coord: 248..349
e-value: 1.2E-105
score: 355.2
NoneNo IPR availablePANTHERPTHR10762:SF12-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1coord: 5..386