early endosome antigen 1-like

Overview


Name	early endosome antigen 1-like
Smed ID	SMED30004587
Length (bp)	1758

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of early endosome antigen 1-like (SMED30004587) t-SNE clustered cells

Violin plots show distribution of expression levels for early endosome antigen 1-like (SMED30004587) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of early endosome antigen 1-like (SMED30004587) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for early endosome antigen 1-like (SMED30004587) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30004587

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30004587	SMESG000008512.1	dd_Smed_v4_5283_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30004587	SMESG000008512.1	dd_Smed_v4_5283_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30004587	SMESG000008512.1	dd_Smed_v4_5283_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30004587	SMESG000008512.1	dd_Smed_v6_5283_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
glial cell	SMED30004587	SMESG000008512.1	dd_Smed_v6_5283_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Human
Match: EEA1 (early endosome antigen 1 [Source:HGNC Symbol;Acc:HGNC:3185])

HSP 1 Score: 116.701 bits (291), Expect = 2.122e-26
Identity = 45/89 (50.56%), Postives = 61/89 (68.54%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            ++ D   +A+ +LGRENQSLQI   +  NR+W  D +   C  C K FS+T+R+HHCR CG + C +CS+K+A    S+KPVRVCDACF
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACF 1406

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Human
Match: RUFY2 (RUN and FYVE domain containing 2 [Source:HGNC Symbol;Acc:HGNC:19761])

HSP 1 Score: 79.337 bits (194), Expect = 7.128e-15
Identity = 31/57 (54.39%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D +A  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  537 WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 593

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Human
Match: RUFY2 (RUN and FYVE domain containing 2 [Source:HGNC Symbol;Acc:HGNC:19761])

HSP 1 Score: 79.337 bits (194), Expect = 8.541e-15
Identity = 31/57 (54.39%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D +A  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  551 WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 607

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Human
Match: RUFY1 (RUN and FYVE domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19760])

HSP 1 Score: 78.9518 bits (193), Expect = 9.496e-15
Identity = 41/95 (43.16%), Postives = 53/95 (55.79%), Query Frame = 2

Query: 1292 KKCKEFDQ-LQSAILDLGRENQSLQISKE---KLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            K C+E +Q LQ   L L +    ++  KE    L    W+ D +A  C  C K FS++ RKHHCRNCG + C  CSS   +L    KPVRVCD+C
Sbjct:  493 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 587

[Close]

Query: 1292 KKCKEFDQ-LQSAILDLGRENQSLQISKE---KLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            K C+E +Q LQ   L L +    ++  KE    L    W+ D +A  C  C K FS++ RKHHCRNCG + C  CSS   +L    KPVRVCD+C
Sbjct:  493 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 587

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Match: eea-1 (EEA1 (Early Endosome Antigen, Rab effector) homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC45])

HSP 1 Score: 119.013 bits (297), Expect = 1.313e-27
Identity = 45/89 (50.56%), Postives = 63/89 (70.79%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            + FD   SA+ +LGR NQSLQI  ++ ++R+W+ D +A+ C  C K FSLT+RKHHCR CG++ C  CSSKS  +A ++ PVR C+ CF
Sbjct: 1112 RRFDDALSAMHELGRANQSLQIDADRYSSRKWLDDAEAINCTECGKVFSLTVRKHHCRVCGKIYCNPCSSKSVRIASAKNPVRACNTCF 1200

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Match: eea-1 (EEA1 (Early Endosome Antigen, Rab effector) homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC45])

HSP 1 Score: 119.013 bits (297), Expect = 1.323e-27
Identity = 45/89 (50.56%), Postives = 63/89 (70.79%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            + FD   SA+ +LGR NQSLQI  ++ ++R+W+ D +A+ C  C K FSLT+RKHHCR CG++ C  CSSKS  +A ++ PVR C+ CF
Sbjct: 1110 RRFDDALSAMHELGRANQSLQIDADRYSSRKWLDDAEAINCTECGKVFSLTVRKHHCRVCGKIYCNPCSSKSVRIASAKNPVRACNTCF 1198

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Match: ZK632.12 (pep chromosome:WBcel235:III:9830802:9832378:1 gene:WBGene00014019.1 transcript:ZK632.12.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.12)

HSP 1 Score: 74.3294 bits (181), Expect = 1.340e-14
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKP-FSLTLRKHHCRNCGQVLCQDCSSKSASL-AVSRKPVRVCDACF 1567
            W+ D +AV+C  C K  F+L  R+HHCRNCG+V+C  CSS++  +  V +KPVRVCD CF
Sbjct:  149 WVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCF 208

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Match: ZK632.12 (pep chromosome:WBcel235:III:9830792:9832430:1 gene:WBGene00014019.1 transcript:ZK632.12.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.12)

HSP 1 Score: 74.3294 bits (181), Expect = 1.340e-14
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKP-FSLTLRKHHCRNCGQVLCQDCSSKSASL-AVSRKPVRVCDACF 1567
            W+ D +AV+C  C K  F+L  R+HHCRNCG+V+C  CSS++  +  V +KPVRVCD CF
Sbjct:  149 WVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKKPVRVCDHCF 208

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Match: lst-2 (Lateral signaling target protein 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9TZD0])

HSP 1 Score: 65.4698 bits (158), Expect = 6.400e-11
Identity = 26/63 (41.27%), Postives = 38/63 (60.32%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASL---AVSRKPVRVCDACFI 1570
            +W+ D D  +C  C  PF+   R+HHCRNCG++ C  CS  + S+      RK VRVC+ C++
Sbjct:  562 RWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNTISIPEHGYDRK-VRVCNLCYV 623

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Match: CG31064 (gene:FBgn0051064 transcript:FBtr0085125)

HSP 1 Score: 70.0922 bits (170), Expect = 2.844e-12
Identity = 33/77 (42.86%), Postives = 43/77 (55.84%), Query Frame = 2

Query: 1352 QSLQISKEKLTNRQ-WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASL----AVSRKPVRVCDACF 1567
            QSLQ   E + +   W  D  A  C  C + F+LT RKHHCR+CG++ C+ CS  +  L        KPVRVCD C+
Sbjct:  650 QSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 726

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Match: CG31064 (gene:FBgn0051064 transcript:FBtr0339249)

HSP 1 Score: 70.4774 bits (171), Expect = 2.875e-12
Identity = 33/77 (42.86%), Postives = 43/77 (55.84%), Query Frame = 2

Query: 1352 QSLQISKEKLTNRQ-WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASL----AVSRKPVRVCDACF 1567
            QSLQ   E + +   W  D  A  C  C + F+LT RKHHCR+CG++ C+ CS  +  L        KPVRVCD C+
Sbjct:  798 QSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCY 874

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Match: CG6051 (gene:FBgn0039492 transcript:FBtr0339264)

HSP 1 Score: 68.9366 bits (167), Expect = 7.667e-12
Identity = 30/66 (45.45%), Postives = 36/66 (54.55%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDACFI 1570
            L+   WI D  A  C  C  PF+   R+HHCRNCG V C  CS+ SA L      K VRVC  C++
Sbjct:  900 LSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCYV 965

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Match: CG6051 (gene:FBgn0039492 transcript:FBtr0305050)

HSP 1 Score: 68.9366 bits (167), Expect = 7.670e-12
Identity = 30/66 (45.45%), Postives = 36/66 (54.55%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDACFI 1570
            L+   WI D  A  C  C  PF+   R+HHCRNCG V C  CS+ SA L      K VRVC  C++
Sbjct:  901 LSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCYV 966

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Match: CG6051 (gene:FBgn0039492 transcript:FBtr0113297)

HSP 1 Score: 68.9366 bits (167), Expect = 7.670e-12
Identity = 30/66 (45.45%), Postives = 36/66 (54.55%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDACFI 1570
            L+   WI D  A  C  C  PF+   R+HHCRNCG V C  CS+ SA L      K VRVC  C++
Sbjct:  901 LSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCYV 966

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 106.686 bits (265), Expect = 1.666e-25
Identity = 44/91 (48.35%), Postives = 62/91 (68.13%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D   +A+ +LGRENQSLQI + +   R+W  D +   C  C K FS+T+RKHHCR+CG + C +CS+++A    S+KPVRVCD CF E
Sbjct:  162 RKLDDTTAAMQELGRENQSLQIKQSQSLTRKWTEDHEVQNCMACGKGFSVTVRKHHCRHCGNIFCAECSARNALTPSSKKPVRVCDNCFDE 252

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 112.079 bits (279), Expect = 3.381e-25
Identity = 44/91 (48.35%), Postives = 62/91 (68.13%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D   +A+ +LGRENQSLQI + +   R+W  D +   C  C K FS+T+RKHHCR+CG + C +CS+++A    S+KPVRVCD CF E
Sbjct: 1305 RKLDDTTAAMQELGRENQSLQIKQSQSLTRKWTEDHEVQNCMACGKGFSVTVRKHHCRHCGNIFCAECSARNALTPSSKKPVRVCDNCFDE 1395

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 83.1889 bits (204), Expect = 2.643e-16
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  547 IEDIKEANKALQ------GGQVWLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 619

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 83.1889 bits (204), Expect = 2.987e-16
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  547 IEDIKEANKALQ------GGQVWLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 619

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 83.1889 bits (204), Expect = 2.987e-16
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  547 IEDIKEANKALQ------GGQVWLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 619

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Match: ovol1 (ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE-5964939])

HSP 1 Score: 108.997 bits (271), Expect = 5.186e-24
Identity = 43/89 (48.31%), Postives = 60/89 (67.42%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            K+ D+   A+ +LGRENQSLQI   +  +R+W  D +   C +C + FS+T+R+HHCR CG + C +CSSK+A    S+K VRVCD CF
Sbjct: 1174 KKVDESSYAMEELGRENQSLQIKHNQALSRKWTEDHEVQNCMSCGRGFSVTIRRHHCRQCGNIFCHECSSKNALTPSSKKAVRVCDTCF 1262

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Match: ovol1 (ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE-5964939])

HSP 1 Score: 108.612 bits (270), Expect = 7.290e-24
Identity = 43/89 (48.31%), Postives = 60/89 (67.42%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            K+ D+   A+ +LGRENQSLQI   +  +R+W  D +   C +C + FS+T+R+HHCR CG + C +CSSK+A    S+K VRVCD CF
Sbjct: 1269 KKVDESSYAMEELGRENQSLQIKHNQALSRKWTEDHEVQNCMSCGRGFSVTIRRHHCRQCGNIFCHECSSKNALTPSSKKAVRVCDTCF 1357

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Match: ovol1 (ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE-5964939])

HSP 1 Score: 108.227 bits (269), Expect = 7.732e-24
Identity = 43/89 (48.31%), Postives = 60/89 (67.42%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            K+ D+   A+ +LGRENQSLQI   +  +R+W  D +   C +C + FS+T+R+HHCR CG + C +CSSK+A    S+K VRVCD CF
Sbjct: 1319 KKVDESSYAMEELGRENQSLQIKHNQALSRKWTEDHEVQNCMSCGRGFSVTIRRHHCRQCGNIFCHECSSKNALTPSSKKAVRVCDTCF 1407

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Match: ovol1 (ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE-5964939])

HSP 1 Score: 108.227 bits (269), Expect = 8.031e-24
Identity = 43/89 (48.31%), Postives = 60/89 (67.42%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            K+ D+   A+ +LGRENQSLQI   +  +R+W  D +   C +C + FS+T+R+HHCR CG + C +CSSK+A    S+K VRVCD CF
Sbjct: 1214 KKVDESSYAMEELGRENQSLQIKHNQALSRKWTEDHEVQNCMSCGRGFSVTIRRHHCRQCGNIFCHECSSKNALTPSSKKAVRVCDTCF 1302

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Match: ovol1 (ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE-5964939])

HSP 1 Score: 107.842 bits (268), Expect = 9.793e-24
Identity = 43/89 (48.31%), Postives = 60/89 (67.42%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            K+ D+   A+ +LGRENQSLQI   +  +R+W  D +   C +C + FS+T+R+HHCR CG + C +CSSK+A    S+K VRVCD CF
Sbjct: 1088 KKVDESSYAMEELGRENQSLQIKHNQALSRKWTEDHEVQNCMSCGRGFSVTIRRHHCRQCGNIFCHECSSKNALTPSSKKAVRVCDTCF 1176

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Match: Eea1 (early endosome antigen 1 [Source:MGI Symbol;Acc:MGI:2442192])

HSP 1 Score: 114.39 bits (285), Expect = 7.785e-26
Identity = 45/89 (50.56%), Postives = 62/89 (69.66%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            ++ D   +A+ +LGRENQSLQI   +  NR+W  D +   C +C K FS+T+R+HHCR CG + C +CS+K+A    S+KPVRVCDACF
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCAECSTKNALTPSSKKPVRVCDACF 1406

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Match: Rufy2 (RUN and FYVE domain-containing 2 [Source:MGI Symbol;Acc:MGI:1917682])

HSP 1 Score: 81.2629 bits (199), Expect = 1.155e-15
Identity = 32/57 (56.14%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D DA  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  537 WLKDKDATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 593

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Match: Rufy1 (RUN and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:2429762])

HSP 1 Score: 78.1814 bits (191), Expect = 1.475e-14
Identity = 41/95 (43.16%), Postives = 53/95 (55.79%), Query Frame = 2

Query: 1292 KKCKEFDQ-LQSAILDLGRENQSLQISKE---KLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            K C+E +Q LQ   L L +    ++  KE    L    W+ D +A  C  C K FS++ RKHHCRNCG + C  CSS   +L    KPVRVCD+C
Sbjct:  605 KVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKGHTWLKDDEATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 699

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Match: Zfyve28 (zinc finger, FYVE domain containing 28 [Source:MGI Symbol;Acc:MGI:2684992])

HSP 1 Score: 67.781 bits (164), Expect = 3.012e-11
Identity = 28/62 (45.16%), Postives = 38/62 (61.29%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLA--VSRKPVRVCDACFI 1570
            +W+ D     C +C  PF++  RKHHCR+CG++ C  CSS SA L      KPVRVC  C++
Sbjct:  831 EWVPDEACGFCTSCKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYM 892

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Match: Fgd6 (FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419])

HSP 1 Score: 63.5438 bits (153), Expect = 5.852e-10
Identity = 28/61 (45.90%), Postives = 36/61 (59.02%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASL-AVSRKPVRVCDACFIE 1573
            WI D  A  C  C   F+LT R+HHCR CG+++CQ CSS    L  +  +  RVC+ CF E
Sbjct: 1188 WIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVCEHCFQE 1248

[Close]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Match: sp|Q15075|EEA1_HUMAN (Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2)

HSP 1 Score: 116.701 bits (291), Expect = 1.019e-25
Identity = 45/89 (50.56%), Postives = 61/89 (68.54%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            ++ D   +A+ +LGRENQSLQI   +  NR+W  D +   C  C K FS+T+R+HHCR CG + C +CS+K+A    S+KPVRVCDACF
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACF 1406

[Close]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Match: sp|Q8BL66|EEA1_MOUSE (Early endosome antigen 1 OS=Mus musculus OX=10090 GN=Eea1 PE=1 SV=2)

HSP 1 Score: 114.39 bits (285), Expect = 5.445e-25
Identity = 45/89 (50.56%), Postives = 62/89 (69.66%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            ++ D   +A+ +LGRENQSLQI   +  NR+W  D +   C +C K FS+T+R+HHCR CG + C +CS+K+A    S+KPVRVCDACF
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMSCGKCFSVTVRRHHCRQCGNIFCAECSTKNALTPSSKKPVRVCDACF 1406

[Close]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Match: sp|Q8R4C2|RUFY2_MOUSE (RUN and FYVE domain-containing protein 2 OS=Mus musculus OX=10090 GN=Rufy2 PE=1 SV=2)

HSP 1 Score: 81.2629 bits (199), Expect = 8.080e-15
Identity = 32/57 (56.14%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D DA  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  537 WLKDKDATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 593

[Close]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Match: sp|Q5R5R4|RUFY2_PONAB (RUN and FYVE domain-containing protein 2 OS=Pongo abelii OX=9601 GN=RUFY2 PE=2 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 3.423e-14
Identity = 31/57 (54.39%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D +A  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  537 WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 593

[Close]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Match: sp|Q8WXA3|RUFY2_HUMAN (RUN and FYVE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RUFY2 PE=1 SV=3)

HSP 1 Score: 79.337 bits (194), Expect = 3.423e-14
Identity = 31/57 (54.39%), Postives = 37/57 (64.91%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D +A  C  C K FSL+ RKHHCRNCG++ C  CS     L  S KPVRVCD+C
Sbjct:  537 WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 593

[Close]

BLAST of early endosome antigen 1-like vs. TrEMBL
Match: V3ZP83 (Uncharacterized protein (Fragment) OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_132243 PE=4 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 1.078e-30
Identity = 52/91 (57.14%), Postives = 69/91 (75.82%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D  ++A+ +LGRENQ+LQI+  K+TNR+W  D +A +C  C K FS+T R+HHCRNCG + C DCSSK+  LA S+KPVRVCDACF E
Sbjct:  203 RKLDDTEAALQELGRENQTLQITSTKVTNRKWTDDTEATDCSACRKAFSVTNRRHHCRNCGHIFCNDCSSKTVPLAASKKPVRVCDACFTE 293

[Close]

BLAST of early endosome antigen 1-like vs. TrEMBL
Match: A0A0V0J4C2 (FYVE-type domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR149303 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 2.452e-28
Identity = 50/91 (54.95%), Postives = 69/91 (75.82%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            +E + LQ  +LDLGR+NQ+LQI+++++T+RQW+ D  A  C  C + FSL+LRKHHCR CG V CQ CS+K A++  S+ P+RVCDACF E
Sbjct:  369 QELESLQRIVLDLGRQNQTLQIAQQRMTSRQWVADESASACSNCQREFSLSLRKHHCRRCGDVFCQTCSTKKATMPASKSPLRVCDACFTE 459

[Close]

BLAST of early endosome antigen 1-like vs. TrEMBL
Match: A0A3P7ESH3 (FYVE-type domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS3550 PE=4 SV=1)

HSP 1 Score: 125.561 bits (314), Expect = 3.659e-28
Identity = 50/90 (55.56%), Postives = 67/90 (74.44%), Query Frame = 2

Query: 1304 EFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            E + LQ  +LDLGR+NQ+LQI++++LTNRQWI D     C  C K FS+++RKHHCR+CG+V CQ CSSK  + + S+ P+RVCD CF E
Sbjct:  218 EMEGLQRIVLDLGRQNQALQITQDRLTNRQWISDDSVQSCSNCQKDFSISVRKHHCRHCGKVFCQACSSKKTATSASKDPLRVCDGCFAE 307

[Close]

BLAST of early endosome antigen 1-like vs. TrEMBL
Match: A0A0R3WS25 (FYVE-type domain-containing protein OS=Hydatigena taeniaeformis OX=6205 PE=4 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 4.115e-28
Identity = 50/90 (55.56%), Postives = 67/90 (74.44%), Query Frame = 2

Query: 1304 EFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            E + LQ  +LDLGR+NQ+LQI++++LTNRQWI D     C  C K FS+++RKHHCR+CG+V CQ CSSK  + + S+ P+RVCD CF E
Sbjct:  218 EMEGLQRIVLDLGRQNQALQITQDRLTNRQWISDDSVQSCSNCQKDFSISVRKHHCRHCGKVFCQACSSKKTATSASKDPLRVCDGCFAE 307

[Close]

BLAST of early endosome antigen 1-like vs. TrEMBL
Match: A0A1S3KAC2 (early endosome antigen 1-like OS=Lingula unguis OX=7574 GN=LOC106179935 PE=4 SV=1)

HSP 1 Score: 130.954 bits (328), Expect = 7.101e-28
Identity = 48/91 (52.75%), Postives = 70/91 (76.92%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++F++  +A+ +LGRENQ LQI   K+  R+W  D + +EC  C KPFS+T+R+HHCRNCGQ+ C +CSS++A++A S+KPVRVCD C+ E
Sbjct: 1570 RKFEETTAALQELGRENQVLQIQTTKVVTRKWADDSEVLECQACSKPFSVTVRRHHCRNCGQIFCHECSSRNATIASSKKPVRVCDTCYGE 1660

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 109.768 bits (273), Expect = 1.719e-24
Identity = 44/91 (48.35%), Postives = 64/91 (70.33%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D   +A+ +LGRENQSLQI + +   R+W  D +   C +C K FS+T+RKHHCR+CG + C +CS+++A    S+KPVRVC+ACF E
Sbjct: 1271 RKLDDTTAAMQELGRENQSLQIKQSQSLTRKWAEDNEVQNCMSCGKGFSVTIRKHHCRHCGNIFCAECSARNALTPSSKKPVRVCEACFEE 1361

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 109.768 bits (273), Expect = 1.815e-24
Identity = 44/91 (48.35%), Postives = 64/91 (70.33%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D   +A+ +LGRENQSLQI + +   R+W  D +   C +C K FS+T+RKHHCR+CG + C +CS+++A    S+KPVRVC+ACF E
Sbjct: 1306 RKLDDTTAAMQELGRENQSLQIKQSQSLTRKWAEDNEVQNCMSCGKGFSVTIRKHHCRHCGNIFCAECSARNALTPSSKKPVRVCEACFEE 1396

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 77.411 bits (189), Expect = 4.549e-16
Identity = 31/57 (54.39%), Postives = 36/57 (63.16%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  112 WLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 168

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 80.1073 bits (196), Expect = 1.931e-15
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  513 IEDIKEANKALQ------GGQVWLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 585

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Match: rufy2 (RUN and FYVE domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070424-66])

HSP 1 Score: 80.4925 bits (197), Expect = 2.016e-15
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  572 IEDIKEANKALQ------GGQVWLKDKDATHCKLCEKEFSISRRKHHCRNCGEIFCNACSDNELPLPASPKPVRVCDTC 644

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Match: eea1 (early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE-041111-270])

HSP 1 Score: 107.842 bits (268), Expect = 1.443e-24
Identity = 41/91 (45.05%), Postives = 65/91 (71.43%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ + + +A+ +LGRENQSLQI   ++ +R+W  D +   C  C K FS+T+RKHHCR+CG + C +CS++++ +  ++KPVRVCD CF E
Sbjct: 1276 RKLEDVTAAMQELGRENQSLQIKHTQVLSRKWAEDGEVQNCMGCGKGFSVTVRKHHCRHCGNIFCGECSARNSMIPSAKKPVRVCDTCFEE 1366

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001934.1 (pep scaffold:Pmarinus_7.0:GL488632:1056:3278:1 gene:ENSPMAG00000001758.1 transcript:ENSPMAT00000001934.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 77.0258 bits (188), Expect = 3.160e-17
Identity = 32/62 (51.61%), Postives = 38/62 (61.29%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            L  + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:   50 LQGQVWLKDQDATNCKLCEKEFSISRRKHHCRNCGEIFCNSCSDNELPLPSSPKPVRVCDLC 111

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005437.1 (pep scaffold:Pmarinus_7.0:GL486528:10206:16522:1 gene:ENSPMAG00000004933.1 transcript:ENSPMAT00000005437.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.855 bits (159), Expect = 4.676e-12
Identity = 29/62 (46.77%), Postives = 39/62 (62.90%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFS-LTLRKHHCRNCGQVLCQDCSSKSASLAV-SRKPVRVCDACFIE 1573
            W+ D++   C TC  PF+ LT R+HHCR CG+V+C  CS     LA   RK  RVC+AC+ +
Sbjct:  228 WVRDVNVTLCMTCQDPFTTLTRRRHHCRACGKVVCWKCSDHRVLLAYEPRKLQRVCEACYAQ 289

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Match: ankfy1 (ankyrin repeat and FYVE domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-041222-1])

HSP 1 Score: 63.929 bits (154), Expect = 7.848e-11
Identity = 27/55 (49.09%), Postives = 34/55 (61.82%), Query Frame = 2

Query: 1409 DAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVS--RKPVRVCDACF 1567
            D   C+ C   F +T RKHHCR+CG++LC  CS+K   +      KPVRVCD CF
Sbjct: 1105 DGSNCYECAAKFGVTTRKHHCRHCGRLLCNRCSAKEIPIIKFDLNKPVRVCDICF 1159

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Match: zfyve1 (zinc finger, FYVE domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-131205-1])

HSP 1 Score: 55.8398 bits (133), Expect = 8.705e-9
Identity = 26/68 (38.24%), Postives = 35/68 (51.47%), Query Frame = 2

Query: 1373 EKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASL---AVSRKPVRVCDACF 1567
            +++    W  +   + C  C+K F     KHHCR CG+  C  CSS+S  +        PVRVCDACF
Sbjct:  114 DQIAPAYWRPNAVVIACHNCNKQFEEKDTKHHCRACGEGFCGACSSRSRPVPERGWGPNPVRVCDACF 181

HSP 2 Score: 47.7506 bits (112), Expect = 3.324e-6
Identity = 28/76 (36.84%), Postives = 38/76 (50.00%), Query Frame = 2

Query: 1349 NQSLQISKEKLTNRQWIGDLDAVECFTCHKPF-SLTLRKHHCRNCGQVLCQDCSSKSASLAVSRK---PVRVCDAC 1564
            N  L + K+      W+ D +   C  C+K   S  L KHHCR CG+  C +CS+    +  SR    PVRVC+ C
Sbjct:  225 NYPLGLVKDVARPTYWVPDHEIASCQDCNKDMTSGKLAKHHCRACGKGFCNECSTARRPVP-SRGWDHPVRVCNTC 299

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Match: VPS27 (Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289])

HSP 1 Score: 68.5514 bits (166), Expect = 1.391e-12
Identity = 35/64 (54.69%), Postives = 39/64 (60.94%), Query Frame = 2

Query: 1382 TNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLA--VSRKPVRVCDACF 1567
            T   WI D DA  C  C K FSL  RKHHCR+CG V CQ+ SS S  L      +PVRVCD+CF
Sbjct:  166 TPADWI-DSDA--CMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCF 226

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Match: PIB2 (Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 [Source:SGD;Acc:S000002991])

HSP 1 Score: 58.151 bits (139), Expect = 2.323e-9
Identity = 22/40 (55.00%), Postives = 25/40 (62.50%), Query Frame = 2

Query: 1382 TNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQD 1501
            T   WI D     C  CHKPF+L  RKHHCR+CG + CQD
Sbjct:  445 TKDHWIPDSKRNSCRYCHKPFTLWERKHHCRHCGDIFCQD 484

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Match: FAB1 (1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [Source:SGD;Acc:S000001915])

HSP 1 Score: 53.1434 bits (126), Expect = 1.050e-7
Identity = 20/43 (46.51%), Postives = 27/43 (62.79%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCS 1507
            L+   W+ D  + ECF+C K F+   RKHHCR CGQ+ C  C+
Sbjct:  232 LSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCT 274

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Match: PEP7 (Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance [Source:SGD;Acc:S000002731])

HSP 1 Score: 51.6026 bits (122), Expect = 2.556e-7
Identity = 22/49 (44.90%), Postives = 29/49 (59.18%), Query Frame = 2

Query: 1361 QISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCS 1507
            ++SK + T   W  D   + C  C +PF L LRKHHCR CG V+C D +
Sbjct:  201 EMSKLERTVTPWRDDRSVLFCNICSEPFGLLLRKHHCRLCGMVVCDDAN 249

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Match: PIB1 (RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain [Source:SGD;Acc:S000002721])

HSP 1 Score: 49.2914 bits (116), Expect = 6.061e-7
Identity = 22/72 (30.56%), Postives = 32/72 (44.44%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLA-------------VSRKPVRVCDACF 1567
            +W  D +A  CF C   FS  +R+HHCR CG++ C  C+    +               V   P R C+ C+
Sbjct:   13 RWQADEEAHSCFQCKTNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKKRVHALQKKNSDVESPPYRTCNECY 84

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Match: EDO44969 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU81])

HSP 1 Score: 84.3445 bits (207), Expect = 7.102e-18
Identity = 32/58 (55.17%), Postives = 41/58 (70.69%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            +W  D +A+ C  C +PFSL+ RKHHCR+CG + CQ CSS +  L  S KPVRVCD+C
Sbjct:  248 KWTDDKEALNCQQCEQPFSLSRRKHHCRSCGGIFCQPCSSNTMPLPSSAKPVRVCDSC 305

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Match: EDO44615 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVB5])

HSP 1 Score: 68.9366 bits (167), Expect = 1.363e-12
Identity = 25/59 (42.37%), Postives = 38/59 (64.41%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            +W    DA EC  C KP +    K+HC +CG++ C+ C SK+ S + +R+P +VCDAC+
Sbjct:  311 RWEHKDDARECRNCQKPLNTNKDKYHCHHCGKIFCEGCRSKTFSNSSTRRPHQVCDACY 369

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Match: EDO38501 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCW3])

HSP 1 Score: 60.8474 bits (146), Expect = 2.003e-10
Identity = 28/60 (46.67%), Postives = 39/60 (65.00%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKP-FSLTLRKHHCRNCGQVLCQDCSSKSASL-AVSRKPVRVCDACF 1567
            W+ D +A  C +C K  F+   R+HHCR CG V+C  CS+K   L A S KP+RVC++C+
Sbjct:  151 WVPDSEASTCMSCMKTKFTAINRRHHCRKCGAVVCGACSTKKFLLPAQSSKPLRVCNSCY 210

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Match: EDO39875 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8S0])

HSP 1 Score: 58.9214 bits (141), Expect = 3.337e-10
Identity = 27/55 (49.09%), Postives = 33/55 (60.00%), Query Frame = 2

Query: 1409 DAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVS--RKPVRVCDACF 1567
            D   C+ C   FS+  RKHHCR+CG++LC  CS K   +      KPVRVCD CF
Sbjct:  111 DGDSCYECGMKFSIKHRKHHCRHCGRLLCAKCSCKQIPIIKYELAKPVRVCDVCF 165

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Match: EDO48232 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKE8])

HSP 1 Score: 61.2326 bits (147), Expect = 5.553e-10
Identity = 25/59 (42.37%), Postives = 32/59 (54.24%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLA-VSRKPVRVCDACF 1567
            WI D     C  C   F++T R+HHCR CG+V+C  CS   A L  +     RVCD C+
Sbjct:  341 WIPDARVTMCMLCTDDFTVTNRRHHCRGCGKVVCGSCSDNLAPLTYLDYAQARVCDMCY 399

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Match: eea1 (early endosome antigen 1 [Source:NCBI gene;Acc:101175647])

HSP 1 Score: 111.694 bits (278), Expect = 3.598e-25
Identity = 44/91 (48.35%), Postives = 62/91 (68.13%), Query Frame = 2

Query: 1301 KEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            ++ D   +A+ +LGRENQSLQI + +   R+W  D +   C  C K FS+T+RKHHCR+CG + C +CSS++A    S+KPVRVC+ CF E
Sbjct: 1261 RKLDDTTAAMQELGRENQSLQIKQSQSLTRKWAEDHEVQNCMACGKGFSVTVRKHHCRHCGNIFCAECSSRNALTPSSKKPVRVCETCFEE 1351

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Match: rufy2 (RUN and FYVE domain containing 2 [Source:NCBI gene;Acc:101165874])

HSP 1 Score: 83.9593 bits (206), Expect = 1.679e-16
Identity = 36/79 (45.57%), Postives = 45/79 (56.96%), Query Frame = 2

Query: 1328 ILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            I D+   N++LQ        + W+ D DA  C  C K FS++ RKHHCRNCG++ C  CS     L  S KPVRVCD C
Sbjct:  618 IEDIKEANKALQ------GGQVWLKDKDATHCKMCEKEFSISRRKHHCRNCGEIFCNSCSDNELPLPASPKPVRVCDTC 690

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Match: rufy1 (RUN and FYVE domain-containing protein 1 [Source:NCBI gene;Acc:101155857])

HSP 1 Score: 77.0258 bits (188), Expect = 1.896e-14
Identity = 30/62 (48.39%), Postives = 37/62 (59.68%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            L    W+ D +A +C  C K FS+  RKHHCRNCG + C  CSS   +L    +PVRVCD C
Sbjct:  495 LKGHAWLKDDEATQCKQCQKEFSIARRKHHCRNCGDIYCNSCSSNELALPSYPRPVRVCDVC 556

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Match: rufy1 (RUN and FYVE domain-containing protein 1 [Source:NCBI gene;Acc:101155857])

HSP 1 Score: 76.6406 bits (187), Expect = 3.055e-14
Identity = 30/62 (48.39%), Postives = 37/62 (59.68%), Query Frame = 2

Query: 1379 LTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            L    W+ D +A +C  C K FS+  RKHHCRNCG + C  CSS   +L    +PVRVCD C
Sbjct:  687 LKGHAWLKDDEATQCKQCQKEFSIARRKHHCRNCGDIYCNSCSSNELALPSYPRPVRVCDVC 748

[Close]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Match: FGD6 (FYVE, RhoGEF and PH domain-containing protein 6 [Source:NCBI gene;Acc:101155348])

HSP 1 Score: 70.4774 bits (171), Expect = 2.969e-12
Identity = 29/58 (50.00%), Postives = 34/58 (58.62%), Query Frame = 2

Query: 1394 WIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACF 1567
            WI D     C  C   F+LT R+HHCR CG+V+CQ CSS    L   +K  RVCD CF
Sbjct:  976 WIPDPRTTMCMICTSEFTLTWRRHHCRACGKVICQGCSSNKHYLQYMKKSDRVCDLCF 1033

[Close]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Match: SMESG000008512.1 (SMESG000008512.1)

HSP 1 Score: 792.727 bits (2046), Expect = 0.000e+0
Identity = 470/474 (99.16%), Postives = 472/474 (99.58%), Query Frame = 2

Query:  152 NHKEKMQSENESNVLLIENLKANIDEQNAKIIHQAQCISQNELRMNQFSEQNAINQNMILNQSNEISNLKIRVSELENEKKHSENTVTELNELINEIESKKKTLLQEKSLLTTEMDLMKKNLFEIEELNTNLKNKNQLMENELLKIKETLKTSNENFETLKKENDKMNNELFICKSQVDNAQELYENSMKLQNEYLHKLDKVTLEYDNTKKRLKEIEEKYSYLQIENSXXXXXXXXXXXXXXNKVSALTKTLNESSENYKQERLEAAEKEFSLISSCEELKTELASLTKSLHRTEEDLETEKNLRESERNNMTEKISQLSXXXXXXXXXXXXXXXKLEIIETENIXXXXXXXXXXXXXXXXXXXXXXXXXSFKKQTDLYSKKCKEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1573
            NHKEKMQSENESNVLLIENLKANIDEQNAKIIHQAQCI QNELRMNQFSEQNAIN+NMILNQSNEISNLKIRVSELE EKKHSENTVTELNELINEIESKKKTLLQEKSLLTTEMDLMKKNLFEIEELNTNLKNKNQLMENELLKIKETLKTSNENFETLKKENDKMNNELFICKSQVDNAQELYENSMKLQNEYLHKLDKVTLEYDNTKKRLK+IEEKYSYLQIENSKELELLKKEEGQLKNKVSALTKTLNESSENYKQERLEAAEKEFSLISSCEELKTELASLTKSLHRTEEDLETEKNLRESERNNMTEKISQLSEQVVVVENVRNECEQKLEIIETENIENKLRLELANEEKEKLLEKIIQLENSFKKQTDLYSKKCKEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE
Sbjct:  616 NHKEKMQSENESNVLLIENLKANIDEQNAKIIHQAQCIIQNELRMNQFSEQNAINKNMILNQSNEISNLKIRVSELEKEKKHSENTVTELNELINEIESKKKTLLQEKSLLTTEMDLMKKNLFEIEELNTNLKNKNQLMENELLKIKETLKTSNENFETLKKENDKMNNELFICKSQVDNAQELYENSMKLQNEYLHKLDKVTLEYDNTKKRLKDIEEKYSYLQIENSKELELLKKEEGQLKNKVSALTKTLNESSENYKQERLEAAEKEFSLISSCEELKTELASLTKSLHRTEEDLETEKNLRESERNNMTEKISQLSEQVVVVENVRNECEQKLEIIETENIENKLRLELANEEKEKLLEKIIQLENSFKKQTDLYSKKCKEFDQLQSAILDLGRENQSLQISKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDACFIE 1089

[Close]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Match: SMESG000050873.1 (SMESG000050873.1)

HSP 1 Score: 81.6481 bits (200), Expect = 5.251e-16
Identity = 31/58 (53.45%), Postives = 39/58 (67.24%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSRKPVRVCDAC 1564
            +W  D +  +C  C KPF+++ RKHHCR CG V C +CSS   SLA S KP+RVCD C
Sbjct:  543 RWTDDKEVNQCIQCAKPFNVSRRKHHCRRCGGVYCHECSSNRMSLASSSKPMRVCDTC 600

[Close]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Match: SMESG000069357.1 (SMESG000069357.1)

HSP 1 Score: 65.855 bits (159), Expect = 5.532e-11
Identity = 26/60 (43.33%), Postives = 34/60 (56.67%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDAC 1564
            +WI D     C  C   F+ +LRKHHCRNCG++ C  CS+    +   +   PVRVCD C
Sbjct:  609 RWIPDHAVTHCSNCKIIFTFSLRKHHCRNCGRIFCHPCSNNRCPIPKQKLNYPVRVCDTC 668

[Close]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Match: SMESG000039846.1 (SMESG000039846.1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.661e-10
Identity = 31/61 (50.82%), Postives = 34/61 (55.74%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDACF 1567
             WI D +A  C  C   FSLT R+HHCRNCG V C  CS     +   R  KPVRVC  CF
Sbjct: 1919 HWIRDENAEVCIGCKIRFSLTERRHHCRNCGLVFCNKCSKHETEIHRLRLFKPVRVCAKCF 1979

[Close]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Match: SMESG000039846.1 (SMESG000039846.1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.884e-10
Identity = 31/61 (50.82%), Postives = 34/61 (55.74%), Query Frame = 2

Query: 1391 QWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKSASLAVSR--KPVRVCDACF 1567
             WI D +A  C  C   FSLT R+HHCRNCG V C  CS     +   R  KPVRVC  CF
Sbjct: 3701 HWIRDENAEVCIGCKIRFSLTERRHHCRNCGLVFCNKCSKHETEIHRLRLFKPVRVCAKCF 3761

The following BLAST results are available for this feature:

BLAST of early endosome antigen 1-like vs. Ensembl Human
BLAST of early endosome antigen 1-like vs. Ensembl Celegans
BLAST of early endosome antigen 1-like vs. Ensembl Fly
BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
BLAST of early endosome antigen 1-like vs. Ensembl Mouse
BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
BLAST of early endosome antigen 1-like vs. TrEMBL
BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
BLAST of early endosome antigen 1-like vs. Ensembl Yeast
BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
BLAST of early endosome antigen 1-like vs. Ensembl Medaka
BLAST of early endosome antigen 1-like vs. Planmine SMEST

BLAST of early endosome antigen 1-like vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
EEA1	2.122e-26	50.56	early endosome antigen 1 [Source:HGNC Symbol;Acc:H...	[more]
RUFY2	7.128e-15	54.39	RUN and FYVE domain containing 2 [Source:HGNC Symb...	[more]
RUFY2	8.541e-15	54.39	RUN and FYVE domain containing 2 [Source:HGNC Symb...	[more]
RUFY1	9.496e-15	43.16	RUN and FYVE domain containing 1 [Source:HGNC Symb...	[more]
RUFY1	9.496e-15	43.16	RUN and FYVE domain containing 1 [Source:HGNC Symb...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eea-1	1.313e-27	50.56	EEA1 (Early Endosome Antigen, Rab effector) homolo...	[more]
eea-1	1.323e-27	50.56	EEA1 (Early Endosome Antigen, Rab effector) homolo...	[more]
ZK632.12	1.340e-14	53.33	pep chromosome:WBcel235:III:9830802:9832378:1 gene...	[more]
ZK632.12	1.340e-14	53.33	pep chromosome:WBcel235:III:9830792:9832430:1 gene...	[more]
lst-2	6.400e-11	41.27	Lateral signaling target protein 2 [Source:UniPro...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG31064	2.844e-12	42.86	gene:FBgn0051064 transcript:FBtr0085125	[more]
CG31064	2.875e-12	42.86	gene:FBgn0051064 transcript:FBtr0339249	[more]
CG6051	7.667e-12	45.45	gene:FBgn0039492 transcript:FBtr0339264	[more]
CG6051	7.670e-12	45.45	gene:FBgn0039492 transcript:FBtr0305050	[more]
CG6051	7.670e-12	45.45	gene:FBgn0039492 transcript:FBtr0113297	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eea1	1.666e-25	48.35	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
eea1	3.381e-25	48.35	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
rufy2	2.643e-16	45.57	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]
rufy2	2.987e-16	45.57	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]
rufy2	2.987e-16	45.57	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ovol1	5.186e-24	48.31	ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE...	[more]
ovol1	7.290e-24	48.31	ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE...	[more]
ovol1	7.732e-24	48.31	ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE...	[more]
ovol1	8.031e-24	48.31	ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE...	[more]
ovol1	9.793e-24	48.31	ovo like zinc finger 1 [Source:Xenbase;Acc:XB-GENE...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Eea1	7.785e-26	50.56	early endosome antigen 1 [Source:MGI Symbol;Acc:MG...	[more]
Rufy2	1.155e-15	56.14	RUN and FYVE domain-containing 2 [Source:MGI Symbo...	[more]
Rufy1	1.475e-14	43.16	RUN and FYVE domain containing 1 [Source:MGI Symbo...	[more]
Zfyve28	3.012e-11	45.16	zinc finger, FYVE domain containing 28 [Source:MGI...	[more]
Fgd6	5.852e-10	45.90	FYVE, RhoGEF and PH domain containing 6 [Source:MG...	[more]

BLAST of early endosome antigen 1-like vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q15075\|EEA1_HUMAN	1.019e-25	50.56	Early endosome antigen 1 OS=Homo sapiens OX=9606 G...	[more]
sp\|Q8BL66\|EEA1_MOUSE	5.445e-25	50.56	Early endosome antigen 1 OS=Mus musculus OX=10090 ...	[more]
sp\|Q8R4C2\|RUFY2_MOUSE	8.080e-15	56.14	RUN and FYVE domain-containing protein 2 OS=Mus mu...	[more]
sp\|Q5R5R4\|RUFY2_PONAB	3.423e-14	54.39	RUN and FYVE domain-containing protein 2 OS=Pongo ...	[more]
sp\|Q8WXA3\|RUFY2_HUMAN	3.423e-14	54.39	RUN and FYVE domain-containing protein 2 OS=Homo s...	[more]

BLAST of early endosome antigen 1-like vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
V3ZP83	1.078e-30	57.14	Uncharacterized protein (Fragment) OS=Lottia gigan...	[more]
A0A0V0J4C2	2.452e-28	54.95	FYVE-type domain-containing protein OS=Schistoceph...	[more]
A0A3P7ESH3	3.659e-28	55.56	FYVE-type domain-containing protein OS=Hydatigena ...	[more]
A0A0R3WS25	4.115e-28	55.56	FYVE-type domain-containing protein OS=Hydatigena ...	[more]
A0A1S3KAC2	7.101e-28	52.75	early endosome antigen 1-like OS=Lingula unguis OX...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eea1	1.719e-24	48.35	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
eea1	1.815e-24	48.35	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
rufy2	4.549e-16	54.39	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]
rufy2	1.931e-15	45.57	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]
rufy2	2.016e-15	45.57	RUN and FYVE domain containing 2 [Source:ZFIN;Acc:...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eea1	1.443e-24	45.05	early endosome antigen 1 [Source:ZFIN;Acc:ZDB-GENE...	[more]
ENSPMAT00000001934.1	3.160e-17	51.61	pep scaffold:Pmarinus_7.0:GL488632:1056:3278:1 gen...	[more]
ENSPMAT00000005437.1	4.676e-12	46.77	pep scaffold:Pmarinus_7.0:GL486528:10206:16522:1 g...	[more]
ankfy1	7.848e-11	49.09	ankyrin repeat and FYVE domain containing 1 [Sourc...	[more]
zfyve1	8.705e-9	38.24	zinc finger, FYVE domain containing 1 [Source:ZFIN...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
VPS27	1.391e-12	54.69	Endosomal protein that forms a complex with Hse1p;...	[more]
PIB2	2.323e-9	55.00	Protein of unknown function; contains FYVE domain;...	[more]
FAB1	1.050e-7	46.51	1-phosphatidylinositol-3-phosphate 5-kinase; vacuo...	[more]
PEP7	2.556e-7	44.90	Adaptor protein involved in vesicle-mediated vacuo...	[more]
PIB1	6.061e-7	30.56	RING-type ubiquitin ligase of the endosomal and va...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO44969	7.102e-18	55.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44615	1.363e-12	42.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38501	2.003e-10	46.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39875	3.337e-10	49.09	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48232	5.553e-10	42.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of early endosome antigen 1-like vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eea1	3.598e-25	48.35	early endosome antigen 1 [Source:NCBI gene;Acc:101...	[more]
rufy2	1.679e-16	45.57	RUN and FYVE domain containing 2 [Source:NCBI gene...	[more]
rufy1	1.896e-14	48.39	RUN and FYVE domain-containing protein 1 [Source:N...	[more]
rufy1	3.055e-14	48.39	RUN and FYVE domain-containing protein 1 [Source:N...	[more]
FGD6	2.969e-12	50.00	FYVE, RhoGEF and PH domain-containing protein 6 [S...	[more]

BLAST of early endosome antigen 1-like vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000008512.1	0.000e+0	99.16	SMESG000008512.1	[more]
SMESG000050873.1	5.251e-16	53.45	SMESG000050873.1	[more]
SMESG000069357.1	5.532e-11	43.33	SMESG000069357.1	[more]
SMESG000039846.1	1.661e-10	50.82	SMESG000039846.1	[more]
SMESG000039846.1	1.884e-10	50.82	SMESG000039846.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30004587 ID=SMED30004587|Name=early endosome antigen 1-like|organism=Schmidtea mediterranea sexual|type=transcript|length=1758bp
CGATCTGTGAATTGTATTTATACATTTTTATTTGAAGTTTTTTATCGATG
TTTCATTAAGATTTTCAATTTTTTCTTTTTATCTCATAAATGATAGGAAA
AAAATATTCCTTATAAAGTTTTGCTTAATGTTGAAAGATTTTTGCTAATA
GAATCACAAGGAAAAAATGCAATCTGAAAACGAATCAAATGTACTTTTGA
TTGAAAATCTTAAAGCTAATATTGATGAACAAAATGCAAAAATTATTCAT
CAAGCACAATGTATTAGTCAAAACGAGTTACGAATGAATCAATTTTCGGA
ACAAAACGCAATTAATCAAAACATGATTTTGAACCAATCAAACGAAATAT
CAAATTTGAAAATTAGAGTGAGTGAGTTAGAAAATGAGAAAAAACATTCA
GAAAATACAGTCACAGAATTAAATGAATTGATAAATGAAATAGAAAGTAA
GAAGAAAACACTTTTACAAGAAAAATCTTTGTTGACAACGGAGATGGATC
TCATGAAGAAAAATCTTTTTGAAATAGAAGAATTGAATACTAATCTTAAA
AATAAGAATCAATTAATGGAAAATGAACTCCTTAAAATTAAGGAAACTTT
GAAAACTTCCAATGAAAATTTTGAAACATTAAAAAAGGAAAACGATAAAA
TGAATAACGAATTGTTCATATGTAAAAGTCAAGTGGACAATGCTCAAGAA
CTGTATGAGAATTCTATGAAATTGCAGAATGAATACCTGCACAAGTTGGA
CAAGGTCACTTTAGAATATGATAATACTAAAAAGCGTCTAAAAGAGATTG
AAGAAAAATATTCGTACTTGCAAATAGAAAACTCTAAGGAACTTGAGTTA
TTAAAAAAAGAAGAAGGTCAATTGAAAAATAAAGTGTCAGCTCTGACAAA
GACTTTAAATGAAAGTTCCGAAAATTACAAACAGGAACGCTTGGAAGCCG
CAGAAAAGGAATTCTCCTTAATAAGTTCATGTGAAGAGCTTAAAACTGAA
TTGGCCAGTCTAACAAAATCTCTTCATCGAACTGAGGAGGATTTAGAAAC
AGAGAAAAATCTTCGTGAATCAGAACGCAACAATATGACGGAAAAAATCT
CTCAATTATCTGAACAGGTTGTTGTCGTAGAAAATGTTAGAAATGAATGT
GAACAGAAATTGGAAATCATTGAAACGGAAAATATTGAAAACAAACTCCG
ACTGGAACTGGCAAATGAAGAAAAAGAAAAACTGTTAGAGAAAATAATTC
AGCTAGAAAATAGTTTTAAAAAACAAACAGATTTATATTCGAAAAAATGT
AAGGAATTCGATCAACTGCAATCGGCGATTTTAGATCTTGGGAGAGAAAA
TCAAAGTTTGCAAATTTCAAAAGAAAAGCTAACTAATCGTCAGTGGATTG
GAGATTTAGATGCTGTAGAGTGTTTCACTTGTCATAAACCATTTTCACTC
ACATTACGGAAGCATCACTGTCGAAATTGTGGCCAAGTTTTGTGTCAAGA
TTGTTCTTCCAAATCTGCAAGTTTAGCAGTTTCTAGAAAACCAGTTCGTG
TTTGTGATGCATGCTTCATTGAAGTGCAATCTCAAAGAAGAAATAGCAGC
GTGAGCTCATCGAATATGAGTCTGCAGATATGAGCCTACAGTTGTTTTTT
ATCTCGCAAAATACATAGTCGCTGTTAAAATTGATTGTGCTGTAAATTAT
TATGCAGAATATTCAAATCATTTTTAAAAAATTAAATCTTTAAGAAGAAT
ATGAATGA

protein sequence of SMED30004587-orf-1

>SMED30004587-orf-1 ID=SMED30004587-orf-1|Name=SMED30004587-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=489bp
MQSENESNVLLIENLKANIDEQNAKIIHQAQCISQNELRMNQFSEQNAIN
QNMILNQSNEISNLKIRVSELENEKKHSENTVTELNELINEIESKKKTLL
QEKSLLTTEMDLMKKNLFEIEELNTNLKNKNQLMENELLKIKETLKTSNE
NFETLKKENDKMNNELFICKSQVDNAQELYENSMKLQNEYLHKLDKVTLE
YDNTKKRLKEIEEKYSYLQIENSKELELLKKEEGQLKNKVSALTKTLNES
SENYKQERLEAAEKEFSLISSCEELKTELASLTKSLHRTEEDLETEKNLR
ESERNNMTEKISQLSEQVVVVENVRNECEQKLEIIETENIENKLRLELAN
EEKEKLLEKIIQLENSFKKQTDLYSKKCKEFDQLQSAILDLGRENQSLQI
SKEKLTNRQWIGDLDAVECFTCHKPFSLTLRKHHCRNCGQVLCQDCSSKS
ASLAVSRKPVRVCDACFIEVQSQRRNSSVSSSNMSLQI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0003116	parenchymal cell
PLANA:0007528	glial cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000306	Znf_FYVE
IPR013083	Znf_RING/FYVE/PHD
IPR017455	Znf_FYVE-rel
IPR011011	Znf_FYVE_PHD

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 226..246
None	No IPR available	COILS	Coil	Coil	coord: 194..221
None	No IPR available	COILS	Coil	Coil	coord: 272..373
None	No IPR available	COILS	Coil	Coil	coord: 54..165
None	No IPR available	COILS	Coil	Coil	coord: 388..408
None	No IPR available	GENE3D	G3DSA:1.20.5.390		coord: 348..409 e-value: 2.4E-10 score: 42.3
None	No IPR available	PANTHER	PTHR23164:SF17	EARLY ENDOSOME ANTIGEN 1	coord: 158..467
None	No IPR available	PANTHER	PTHR23164	EARLY ENDOSOME ANTIGEN 1	coord: 158..467
None	No IPR available	CDD	cd15730	FYVE_EEA1	coord: 408..470 e-value: 2.61532E-30 score: 110.181
None	No IPR available	SUPERFAMILY	SSF69979	Eea1 homodimerisation domain	coord: 351..408
IPR000306	FYVE zinc finger	SMART	SM00064	fyve_4	coord: 405..472 e-value: 5.8E-25 score: 98.9
IPR000306	FYVE zinc finger	PFAM	PF01363	FYVE	coord: 409..471 e-value: 6.3E-18 score: 64.7
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 410..472 e-value: 1.3E-20 score: 75.2
IPR017455	Zinc finger, FYVE-related	PROSITE	PS50178	ZF_FYVE	coord: 413..471 score: 13.706
IPR011011	Zinc finger, FYVE/PHD-type	SUPERFAMILY	SSF57903	FYVE/PHD zinc finger	coord: 409..477