Receptor protein-tyrosine kinase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004568 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 266.544 bits (680), Expect = 7.051e-72 Identity = 205/621 (33.01%), Postives = 299/621 (48.15%), Query Frame = 2
Query: 2012 PGIGGCNKCERILLSRKADIVSCVKTC--HEGTY-AFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFT 3778
PG C C R R C+++C ++G + F N G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++IV +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L +++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F
Sbjct: 489 PGPDQCLSCRRFSRGR-----ICIESCNLYDGEFREFEN------------GSICVECDPQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFV 1023 HSP 2 Score: 148.673 bits (374), Expect = 3.390e-35 Identity = 159/665 (23.91%), Postives = 259/665 (38.95%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F S+ E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W ++ +P L ++ S C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + S PN+ + F+ + + + L +SLKEI+ G N LCY + I LF + I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C P+C L TC GP P+ C K C + ++ CV C + + + C PCHPNC++ C GP+S
Sbjct: 2 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQDIVRNPWPSNL--------TLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLN--------------------IQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI----CVECDPQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG----CNGPTS 604 HSP 3 Score: 63.929 bits (154), Expect = 3.025e-9 Identity = 82/294 (27.89%), Postives = 128/294 (43.54%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL--GI-----TKLESKERE-LN-FDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK-----CSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L GI +E+ + E LN F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ T+ + +++RD C+ + + + + CWGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 299 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQC----LSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 567
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 266.159 bits (679), Expect = 1.142e-71 Identity = 205/621 (33.01%), Postives = 299/621 (48.15%), Query Frame = 2
Query: 2012 PGIGGCNKCERILLSRKADIVSCVKTC--HEGTY-AFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFT 3778
PG C C R R C+++C ++G + F N G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++IV +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L +++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F
Sbjct: 515 PGPDQCLSCRRFSRGR-----ICIESCNLYDGEFREFEN------------GSICVECDPQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFV 1049 HSP 2 Score: 148.288 bits (373), Expect = 4.361e-35 Identity = 159/665 (23.91%), Postives = 259/665 (38.95%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F S+ E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W ++ +P L ++ S C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + S PN+ + F+ + + + L +SLKEI+ G N LCY + I LF + I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C P+C L TC GP P+ C K C + ++ CV C + + + C PCHPNC++ C GP+S
Sbjct: 28 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQDIVRNPWPSNL--------TLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLN--------------------IQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI----CVECDPQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG----CNGPTS 630 HSP 3 Score: 63.5438 bits (153), Expect = 3.365e-9 Identity = 82/294 (27.89%), Postives = 128/294 (43.54%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL--GI-----TKLESKERE-LN-FDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK-----CSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L GI +E+ + E LN F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ T+ + +++RD C+ + + + + CWGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 325 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQC----LSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 593
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 264.233 bits (674), Expect = 4.369e-71 Identity = 204/616 (33.12%), Postives = 298/616 (48.38%), Query Frame = 2
Query: 2012 PGIGGCNKCERILLSRKADIVSCVKTC--HEGTY-AFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRD 3763
PG C C R R C+++C ++G + F N G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++IV +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L +++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID +
Sbjct: 515 PGPDQCLSCRRFSRGR-----ICIESCNLYDGEFREFEN------------GSICVECDPQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRARIDSN 1044 HSP 2 Score: 147.902 bits (372), Expect = 5.417e-35 Identity = 159/665 (23.91%), Postives = 259/665 (38.95%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F S+ E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W ++ +P L ++ S C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + S PN+ + F+ + + + L +SLKEI+ G N LCY + I LF + I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C P+C L TC GP P+ C K C + ++ CV C + + + C PCHPNC++ C GP+S
Sbjct: 28 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQDIVRNPWPSNL--------TLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLN--------------------IQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI----CVECDPQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG----CNGPTS 630 HSP 3 Score: 63.929 bits (154), Expect = 3.181e-9 Identity = 82/294 (27.89%), Postives = 128/294 (43.54%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL--GI-----TKLESKERE-LN-FDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK-----CSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L GI +E+ + E LN F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ T+ + +++RD C+ + + + + CWGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 325 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQC----LSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 593
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 246.514 bits (628), Expect = 5.448e-66 Identity = 136/345 (39.42%), Postives = 205/345 (59.42%), Query Frame = 2
Query: 2615 YLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
+++R+ I + + L EP + + PN L I+ + + + K LG GAFG VYKG W IP+ E+ +PVAIK ++ + + + ++ EA +MASV + H R +G+CL+ LI+ + G L ++ +K+ I S +L+W QIA GM YL R ++HRDLAARNVLV + V+ITDFGL+K+L ++KE + GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ +I + KG RL QP IC++DVY+IMV CW+ + RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 622 FMRRRHIVRKRTLRRLLQERELVEPLTPS----GEAPNQALLRILKETEF---KKIKVLGSGAFGTVYKGLW-IPEGEKV---------KIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSP 947 HSP 2 Score: 137.502 bits (345), Expect = 6.864e-32 Identity = 165/656 (25.15%), Postives = 253/656 (38.57%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRS-KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPA-MMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG-----YIVLTEDSFVKHNITVEMLYENLNKLQELEGGF--SYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN-----TCVGPNPNQCIKGCKNKRENGTCVASCSKN--------FYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGC 2029
+CQ + ++ L + + LS+ R NC + G++ I + + +L+F +I+E+ G+++I N +E+I +NL+IIRG N N ++L V N +D+N T K+L +R+ +C + CWG CQ+ T +C + S C CC++QC GC G S C C+ +E C + C Y+ N E +Y G C K+CP ++ ++ CV C ++ + + C KC G CN I D + A ++ KNC I G + DSF + L ++E+ G + +N F + H A+ + LGL+SLKEI +G N+ LCY N I +LF I SN T ++CH CS +GCWGP + C CR CV C+ +G P + N +C++CHPECL TC G P+ CI+ C + + CV +C + + C CHPNC+ Y CTG PG+ GC
Sbjct: 30 VCQGTSNKLTQLGTFEDHF--LSLQRMFNNCEVVLGNLEITYV----QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRG-NMYYEN-------SYALAVLSN--------------------YDANK--------------------------TGLKELPMRNLQGQKCD--PSCPNGSCWGAGEENCQKLTKIICAQQCSGRCR-----GKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC----RKVCNGIGIGEFKD---SLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQF-------SLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEG--EP--REFVENSECIQCHPECLPQAMNITCTGRGPDNCIQ-CAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT-YG---CTG----PGLEGC 591
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 247.284 bits (630), Expect = 5.656e-66 Identity = 136/345 (39.42%), Postives = 205/345 (59.42%), Query Frame = 2
Query: 2615 YLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
+++R+ I + + L EP + + PN L I+ + + + K LG GAFG VYKG W IP+ E+ +PVAIK ++ + + + ++ EA +MASV + H R +G+CL+ LI+ + G L ++ +K+ I S +L+W QIA GM YL R ++HRDLAARNVLV + V+ITDFGL+K+L ++KE + GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ +I + KG RL QP IC++DVY+IMV CW+ + RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 622 FMRRRHIVRKRTLRRLLQERELVEPLTPS----GEAPNQALLRILKETEF---KKIKVLGSGAFGTVYKGLW-IPEGEKV---------KIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSP 947 HSP 2 Score: 137.887 bits (346), Expect = 7.057e-32 Identity = 167/660 (25.30%), Postives = 254/660 (38.48%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRS-KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRD----KCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPA-MMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG-----YIVLTEDSFVKHNITVEMLYENLNKLQELEGGF--SYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN-----TCVGPNPNQCIKGCKNKRENGTCVASCSKN--------FYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGC 2029
+CQ + ++ L + + LS+ R NC + G++ I + + +L+F +I+E+ G+++I N +E+I +NL+IIRG N N ++L V N +D+N T K+L +R+ KC C + CWG CQ+ T +C + S C CC++QC GC G S C C+ +E C + C Y+ N E +Y G C K+CP ++ ++ CV C ++ + + C KC G CN I D + A ++ KNC I G + DSF + L ++E+ G + +N F + H A+ + LGL+SLKEI +G N+ LCY N I +LF I SN T ++CH CS +GCWGP + C CR CV C+ +G P + N +C++CHPECL TC G P+ CI+ C + + CV +C + + C CHPNC+ Y CTG PG+ GC
Sbjct: 30 VCQGTSNKLTQLGTFEDHF--LSLQRMFNNCEVVLGNLEITYV----QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRG-NMYYEN-------SYALAVLSN--------------------YDANK--------------------------TGLKELPMRNLQGQKCDPSCPNGS------CWGAGEENCQKLTKIICAQQCSGRCR-----GKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC----RKVCNGIGIGEFKD---SLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQF-------SLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEG--EP--REFVENSECIQCHPECLPQAMNITCTGRGPDNCIQ-CAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT-YG---CTG----PGLEGC 591
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 416.772 bits (1070), Expect = 9.598e-123 Identity = 339/1136 (29.84%), Postives = 526/1136 (46.30%), Query Frame = 2
Query: 338 FDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQ-GCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKS---NHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNI----TVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYM-----NIPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGT-------CVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPD--ISRF--YPVTGFTCLPCPELCSKCK--GKSPKNDECEVCKGVWHK-----NTCRLRCPRDESYGTKIIDSISYCKTCHSSCKG---CYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
FD++EEI G LII +++KI+F LR+I G D+ D +L + N + ++ R LR I +V NPKM Y+ I W EL DP Q + + + K +C N CWG N CQ+ +++C C+ C Y N CC+ CLGGC G G C AC + C+E C R ++ G + N + RY G C K+CP +L EN CV CS+G+ + + C KC + C + + GH L + L L+ C++I G++++ E +F + TV+++ E + +Q+ + K+ L LH+ L Y +LE L L SLK I G KN +LCY+ + + K+ K I N ++C K+C+++GCWG + C EC+ + + GTCV C K N ++ KC RC PEC TC G C+ C++K + CV C + +P C CHP C + CTGP S G GGC +C + + + D + C+++ ND P+ IS + V C C C C G++ ++C VCK V ++ C +CP + +++ CK CH C C C +CKN ++ C CP K++ +G+ CL + +R V + + ++ + ++VY + + I ++++ LT ++ S PNM R+ ++ +L + + K LG GAFG V+ G + K + + +PVAIKV + + + +++EA M + H + L+ IG C+ + +++ Y G+L FL +K + + + + QIA GM YL K+ ++HRDLA RNVLV + V+ITDFGLSK+L+ D I IK+GKV I+WLAIE + Y+H +DVWA+GVT WEI TFG+ PY+ +T I +F+ G RLSQP CS D+Y ++ CW+ P RP F+ L + F ++CK P +L
Sbjct: 48 FDNLEEIRGSLIIYRANIQKISFPRLRVIYG---------DEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDK---CWGSGDNDCQRVYRSVC----PKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCP------KICTVDGH--------LTNETLKNLEGCEQIDGHLII-EHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKN-----------LQIIEGRKLHNVRWALAIYQC-----DDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQ------TSMKCERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFP--TQKNVCEKCHPTCYDNG---CTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTV--CKKCHHECDQNYHCANGQSTGCQKCKNFTVF-KGDIAQCVSECP--KNLPFSNPANGE--CLDY-----DIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDA------SVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIY---------YPKRAKNVKIPVAIKVFQT-DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDAD-SITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL 1091
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 416.387 bits (1069), Expect = 4.456e-122 Identity = 339/1136 (29.84%), Postives = 526/1136 (46.30%), Query Frame = 2
Query: 338 FDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQ-GCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKS---NHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNI----TVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYM-----NIPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGT-------CVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPD--ISRF--YPVTGFTCLPCPELCSKCK--GKSPKNDECEVCKGVWHK-----NTCRLRCPRDESYGTKIIDSISYCKTCHSSCKG---CYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
FD++EEI G LII +++KI+F LR+I G D+ D +L + N + ++ R LR I +V NPKM Y+ I W EL DP Q + + + K +C N CWG N CQ+ +++C C+ C Y N CC+ CLGGC G G C AC + C+E C R ++ G + N + RY G C K+CP +L EN CV CS+G+ + + C KC + C + + GH L + L L+ C++I G++++ E +F + TV+++ E + +Q+ + K+ L LH+ L Y +LE L L SLK I G KN +LCY+ + + K+ K I N ++C K+C+++GCWG + C EC+ + + GTCV C K N ++ KC RC PEC TC G C+ C++K + CV C + +P C CHP C + CTGP S G GGC +C + + + D + C+++ ND P+ IS + V C C C C G++ ++C VCK V ++ C +CP + +++ CK CH C C C +CKN ++ C CP K++ +G+ CL + +R V + + ++ + ++VY + + I ++++ LT ++ S PNM R+ ++ +L + + K LG GAFG V+ G + K + + +PVAIKV + + + +++EA M + H + L+ IG C+ + +++ Y G+L FL +K + + + + QIA GM YL K+ ++HRDLA RNVLV + V+ITDFGLSK+L+ D I IK+GKV I+WLAIE + Y+H +DVWA+GVT WEI TFG+ PY+ +T I +F+ G RLSQP CS D+Y ++ CW+ P RP F+ L + F ++CK P +L
Sbjct: 114 FDNLEEIRGSLIIYRANIQKISFPRLRVIYG---------DEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDK---CWGSGDNDCQRVYRSVC----PKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCP------KICTVDGH--------LTNETLKNLEGCEQIDGHLII-EHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKN-----------LQIIEGRKLHNVRWALAIYQC-----DDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQ------TSMKCERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFP--TQKNVCEKCHPTCYDNG---CTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTV--CKKCHHECDQNYHCANGQSTGCQKCKNFTVF-KGDIAQCVSECP--KNLPFSNPANGE--CLDY-----DIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDA------SVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIY---------YPKRAKNVKIPVAIKVFQT-DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDAD-SITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL 1157
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 416.001 bits (1068), Expect = 4.766e-122 Identity = 339/1136 (29.84%), Postives = 526/1136 (46.30%), Query Frame = 2
Query: 338 FDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQ-GCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKS---NHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNI----TVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYM-----NIPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGT-------CVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPD--ISRF--YPVTGFTCLPCPELCSKCK--GKSPKNDECEVCKGVWHK-----NTCRLRCPRDESYGTKIIDSISYCKTCHSSCKG---CYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
FD++EEI G LII +++KI+F LR+I G D+ D +L + N + ++ R LR I +V NPKM Y+ I W EL DP Q + + + K +C N CWG N CQ+ +++C C+ C Y N CC+ CLGGC G G C AC + C+E C R ++ G + N + RY G C K+CP +L EN CV CS+G+ + + C KC + C + + GH L + L L+ C++I G++++ E +F + TV+++ E + +Q+ + K+ L LH+ L Y +LE L L SLK I G KN +LCY+ + + K+ K I N ++C K+C+++GCWG + C EC+ + + GTCV C K N ++ KC RC PEC TC G C+ C++K + CV C + +P C CHP C + CTGP S G GGC +C + + + D + C+++ ND P+ IS + V C C C C G++ ++C VCK V ++ C +CP + +++ CK CH C C C +CKN ++ C CP K++ +G+ CL + +R V + + ++ + ++VY + + I ++++ LT ++ S PNM R+ ++ +L + + K LG GAFG V+ G + K + + +PVAIKV + + + +++EA M + H + L+ IG C+ + +++ Y G+L FL +K + + + + QIA GM YL K+ ++HRDLA RNVLV + V+ITDFGLSK+L+ D I IK+GKV I+WLAIE + Y+H +DVWA+GVT WEI TFG+ PY+ +T I +F+ G RLSQP CS D+Y ++ CW+ P RP F+ L + F ++CK P +L
Sbjct: 109 FDNLEEIRGSLIIYRANIQKISFPRLRVIYG---------DEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDK---CWGSGDNDCQRVYRSVC----PKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCP------KICTVDGH--------LTNETLKNLEGCEQIDGHLII-EHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKN-----------LQIIEGRKLHNVRWALAIYQC-----DDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQ------TSMKCERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFP--TQKNVCEKCHPTCYDNG---CTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTV--CKKCHHECDQNYHCANGQSTGCQKCKNFTVF-KGDIAQCVSECP--KNLPFSNPANGE--CLDY-----DIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDA------SVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIY---------YPKRAKNVKIPVAIKVFQT-DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDAD-SITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL 1152
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 416.387 bits (1069), Expect = 4.784e-122 Identity = 339/1136 (29.84%), Postives = 525/1136 (46.21%), Query Frame = 2
Query: 338 FDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQ-GCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKS---NHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNI----TVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYM-----NIPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKR-------ENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPD--ISRF--YPVTGFTCLPCPELCSKCK--GKSPKNDECEVCKGVWHK-----NTCRLRCPRDESYGTKIIDSISYCKTCHSSCKG---CYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
FD++EEI G LII +++KI+F LR+I G D+ D +L + N + ++ R LR I +V NPKM Y+ I W EL DP Q + + + K +C N CWG N CQ+ +++C C+ C Y N CC+ CLGGC G G C AC + C+E C R ++ G + N + RY G C K+CP +L EN CV CS+G+ + + C KC + C + + GH L + L L+ C++I G++++ E +F + TV+++ E + +Q+ + K+ L LH+ L Y +LE L L SLK I G KN +LCY+ + + K+ K I N ++C K+C+++GCWG + C EC+ + + GTCV C K N ++ KC RC PEC TC G C+ C++K CV C + +P C CHP C + CTGP S G GGC +C + + + D + C+++ ND P+ IS + V C C C C G++ ++C VCK V ++ C +CP + +++ CK CH C C C +CKN ++ C CP K++ +G+ CL + +R V + + ++ + ++VY + + I ++++ LT ++ S PNM R+ ++ +L + + K LG GAFG V+ G + K + + +PVAIKV + + + +++EA M + H + L+ IG C+ + +++ Y G+L FL +K + + + + QIA GM YL K+ ++HRDLA RNVLV + V+ITDFGLSK+L+ D I IK+GKV I+WLAIE + Y+H +DVWA+GVT WEI TFG+ PY+ +T I +F+ G RLSQP CS D+Y ++ CW+ P RP F+ L + F ++CK P +L
Sbjct: 121 FDNLEEIRGSLIIYRANIQKISFPRLRVIYG---------DEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDK---CWGSGDNDCQRVYRSVC----PKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCP------KICTVDGH--------LTNETLKNLEGCEQIDGHLII-EHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKN-----------LQIIEGRKLHNVRWALAIYQC-----DDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQ------TSMKCERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFP--TQKNVCEKCHPTCYDNG---CTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTV--CKKCHHECDQNYHCANGQSTGCQKCKNFTVF-KGDIAQCVSECP--KNLPFSNPANGE--CLDY-----DIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDA------SVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIY---------YPKRAKNVKIPVAIKVFQT-DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS-ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL 1164
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 177.563 bits (449), Expect = 2.279e-47 Identity = 109/303 (35.97%), Postives = 166/303 (54.79%), Query Frame = 2
Query: 2699 DEDLLSKPPN------MGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIK-NMGNEEIESVMQEAKMMASVS-HMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFL--IRNKNKITSLI----MLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLM 3565
+ ++L +PPN G +I ++ ++ +G GAFG V+KG + P + +PVA+K +K N +EE E ++E +MM +V H + + G C+ + C+I YV G L +L +R + S I LS++ QIA GM +L IIHRDLAARN+LV + ++I+DFG+S+ I + G +P+RWL+ E + D YS+++DVWA+GV LWEI T G PY + A DI + + +G RL QP CS D+YI+M +CW RP F ++
Sbjct: 163 ETNILYRPPNEVNGGTTGEWLIRGQDIVV----GAVIGEGAFGQVFKGILRGPNGQ-----------VIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR-----PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAIL 445
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653) HSP 1 Score: 441.81 bits (1135), Expect = 1.121e-130 Identity = 347/1184 (29.31%), Postives = 554/1184 (46.79%), Query Frame = 2
Query: 254 RSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF-----VKHNITVEMLY--------ENLNKLQELEG------------GFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYM-NIPVNELFKNVKNFYYIPSNCTDKICHKD-------CSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCV---KTCHEG---TYAFPNDRPDISRFYPVTG-FTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKI--------YLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMG----RLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIK-VIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPY 3628
R NCT++ G+ L +T L ++ +L+F D+I E+ G+++I D++K+ F L+IIRG ++ ++ ++L V+ + + L+ LR + V F +N + ++ +I+W+E+ ++ ++ T KC + C CWG CQ+ + C S +C R + + CC+ C GGC G C ACKN +E C E C Y+ TN E +Y G C K+CP +L +N CV C + +K C+ C G PC G T L A ++ +NC I G I + + +F V N T+ Y E + ++E+ G SYF++ +H + AI ++ L L +++LK+I+ G N+ LCY+ NI + K + ++ N +C K+ C+E GCWG G C C+ ++ GTC++DC G+ + N+ N+ C CHPEC TC G + C + C + R+ CV+ C KN Y ND C CH C CTGP GIG C C +++ A + C+ C +G Y P ++ + P+ G C C LC C C C + C CP D + + C CH C GC G +C C+N K+ Y++ F C CP + + C + +K+ ++ + +L+ I ++ + ++K A++ ++ S +D + L +P N+G +L IV +L + LG GAFG VYKG W +P+ E + +PVAIK ++K+ G E E ++EA +MASV H++ L+ + VC+S + LI+ + G L ++ N++KI S +L+WS QIA GM YL ++ ++HRDLAARNVLV V+ITDFGL+K+L S+ E GK+PI+WLA+E + + ++ ++DVWA+GVT+WE+ TFG+ P+E+ DI D + G +L QP+ICSLD+Y +++CW +RP F+ L F ++ ++PGRYL+I GD +
Sbjct: 76 RYTNCTYVDGN---LELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEE---KYALFVT-YSKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSN-GTDAYYNYDFTAPERECPKCHESCTHG-------CWGEGPKNCQKFSKLTC----SPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM-DKGGECVPCNG--------PCPK-TCPGVT------VLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRN----------------LETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYIS--NAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKY---NDRGVCRECHATCDG-----CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLK---PLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSG-----CEDSEPL-RPSNIGANLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGE---------NVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLL-SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKF 1163
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654) HSP 1 Score: 442.58 bits (1137), Expect = 1.512e-130 Identity = 347/1184 (29.31%), Postives = 554/1184 (46.79%), Query Frame = 2
Query: 254 RSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF-----VKHNITVEMLY--------ENLNKLQELEG------------GFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYM-NIPVNELFKNVKNFYYIPSNCTDKICHKD-------CSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCV---KTCHEG---TYAFPNDRPDISRFYPVTG-FTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKI--------YLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMG----RLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIK-VIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPY 3628
R NCT++ G+ L +T L ++ +L+F D+I E+ G+++I D++K+ F L+IIRG ++ ++ ++L V+ + + L+ LR + V F +N + ++ +I+W+E+ ++ ++ T KC + C CWG CQ+ + C S +C R + + CC+ C GGC G C ACKN +E C E C Y+ TN E +Y G C K+CP +L +N CV C + +K C+ C G PC G T L A ++ +NC I G I + + +F V N T+ Y E + ++E+ G SYF++ +H + AI ++ L L +++LK+I+ G N+ LCY+ NI + K + ++ N +C K+ C+E GCWG G C C+ ++ GTC++DC G+ + N+ N+ C CHPEC TC G + C + C + R+ CV+ C KN Y ND C CH C CTGP GIG C C +++ A + C+ C +G Y P ++ + P+ G C C LC C C C + C CP D + + C CH C GC G +C C+N K+ Y++ F C CP + + C + +K+ ++ + +L+ I ++ + ++K A++ ++ S +D + L +P N+G +L IV +L + LG GAFG VYKG W +P+ E + +PVAIK ++K+ G E E ++EA +MASV H++ L+ + VC+S + LI+ + G L ++ N++KI S +L+WS QIA GM YL ++ ++HRDLAARNVLV V+ITDFGL+K+L S+ E GK+PI+WLA+E + + ++ ++DVWA+GVT+WE+ TFG+ P+E+ DI D + G +L QP+ICSLD+Y +++CW +RP F+ L F ++ ++PGRYL+I GD +
Sbjct: 125 RYTNCTYVDGN---LELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEE---KYALFVT-YSKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSN-GTDAYYNYDFTAPERECPKCHESCTHG-------CWGEGPKNCQKFSKLTC----SPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM-DKGGECVPCNG--------PCPK-TCPGVT------VLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRN----------------LETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYIS--NAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKY---NDRGVCRECHATCDG-----CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLK---PLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSG-----CEDSEPL-RPSNIGANLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGE---------NVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLL-SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKF 1212
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0301285) HSP 1 Score: 179.104 bits (453), Expect = 4.396e-45 Identity = 102/303 (33.66%), Postives = 160/303 (52.81%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIE-SVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQF 3694
+G G FG V +G+ KIP N ++ + VAIK +K +E+ + EA +M H + + GV +I+ Y++ GSLD FL N K +L ++ IA GM YL+ N +HRDLAARNVLV+ +I DFGLS+ +E+ D + GK+P+RW A E + K++ +DVW+YGV LWE+ ++G+ PY + + D+ + KG RL P C +Y +M++CW + RP F +++ T + + P L+ + PSP S + G++ F
Sbjct: 714 IGGGEFGDVCRGRLKIPPN---FVQD------IDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR------PSPESDGNHILDGQRGQNIF 1000
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0089083) HSP 1 Score: 178.333 bits (451), Expect = 7.207e-45 Identity = 102/303 (33.66%), Postives = 160/303 (52.81%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIE-SVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQF 3694
+G G FG V +G+ KIP N ++ + VAIK +K +E+ + EA +M H + + GV +I+ Y++ GSLD FL N K +L ++ IA GM YL+ N +HRDLAARNVLV+ +I DFGLS+ +E+ D + GK+P+RW A E + K++ +DVW+YGV LWE+ ++G+ PY + + D+ + KG RL P C +Y +M++CW + RP F +++ T + + P L+ + PSP S + G++ F
Sbjct: 698 IGGGEFGDVCRGRLKIPPN---FVQD------IDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR------PSPESDGNHILDGQRGQNIF 984
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0089082) HSP 1 Score: 178.333 bits (451), Expect = 8.047e-45 Identity = 102/303 (33.66%), Postives = 160/303 (52.81%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIE-SVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQF 3694
+G G FG V +G+ KIP N ++ + VAIK +K +E+ + EA +M H + + GV +I+ Y++ GSLD FL N K +L ++ IA GM YL+ N +HRDLAARNVLV+ +I DFGLS+ +E+ D + GK+P+RW A E + K++ +DVW+YGV LWE+ ++G+ PY + + D+ + KG RL P C +Y +M++CW + RP F +++ T + + P L+ + PSP S + G++ F
Sbjct: 731 IGGGEFGDVCRGRLKIPPN---FVQD------IDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR------PSPESDGNHILDGQRGQNIF 1017
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 269.626 bits (688), Expect = 5.685e-73 Identity = 203/602 (33.72%), Postives = 317/602 (52.66%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKS-----PKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVE-EIEKGSGDIVCLSL-WESKAKLEE----TKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
KN P SK C P CSE C GP G C C+ SR +CVK+C+ Y D+ F G C+ C C K K P D C C + C +CP S+ K ++ + C CH +C GS N RC+ + +Y + C++ P++S +++ D + L++ + + ++++ RT + ++ L +++I+ + + VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ ++ G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +++ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L+ T +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+
Sbjct: 461 KNNREPRECSKEQKICDPLCSEAG---CWGP----GPDQCLSCK--YFSRGK---TCVKSCNL-YYG------DVREF--ANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCT--QGSVACNRFRCRTRILY----RTSCDN---PMQSYNCSLDRNMFDAMFLNVTYCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GAAPNQAQLRILKETEL---KRVKILGAGAFGMVYKGIW-VPEGETV---------KIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLD-TDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN 1006 HSP 2 Score: 155.221 bits (391), Expect = 2.222e-37 Identity = 160/621 (25.76%), Postives = 260/621 (41.87%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELE--GGFSYFKD--NHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLC-YMNIPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSE 1975
+NC + G++ I I + R L+F SI E+ G++++ N + + +NLRIIRG + +G ++ ++ G L L ++L I V D N K+L H+ I W+++ +P++++L P+ + + CK CWG +QCQ +T+C + C N CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC K+CP + +++ CV C +N++ CI C ++C D + ++A D +N + + NC KI G ++ F+ I +M + + LN + + GF + ++ +L NL L+S I L ++ S L +SL+EI+ G N +LC Y + LF+ I P C+ KIC CSE GCWGPG C C+ + TCV C+ +Y + + C+ C +C TC GP P+ C+K C + ++ CV C + + C PCHPNC++
Sbjct: 27 ENCEVVMGNLEITSI----ERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK------LYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQN---KFLCHADTIHWHDIIKNPRSELLVVPS--------NNSGNTCKRCHRSCNGRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSN-----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCT-DICPKVCDGIGTGSLQMAQTVDSSN--------IEKFVNCTKINGNLI-----FLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITS------LQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNL---YYGDVR-EFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVK-CLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQ 596 HSP 3 Score: 60.8474 bits (146), Expect = 1.385e-8 Identity = 77/298 (25.84%), Postives = 120/298 (40.27%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSECTTC------------RYINGEEQGCCNDQCLGG------CNGGGASKCTACKNMLNEKKCVELCRGPYSGG 958
P T IC D + SL + + + +I + NCT I G++ L GI L+ +R F ++ EI G L ++ N + F NL I G R+L ++ SL++ + L F+SLR I+A NV +N ++ + ++ W LF + L K+ +CS + K+ ++ CWGP +QC KY S TC + NG C+ QC C+G G C C ++ + CVE C G
Sbjct: 298 PCTDICPKVCDGIGTGSLQMA-QTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDP-DRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGG-----RSL----YSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFY-STVNWTSLFRTSTQRALI-----KNNREPRECSKEQKICDPLCSEAGCWGPGPDQC-----LSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGA 573
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 264.618 bits (675), Expect = 1.234e-71 Identity = 202/596 (33.89%), Postives = 293/596 (49.16%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKS-----PKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
KN P SK C P CSE C GP G C C+ SR +CVK+C+ Y D+ F G C+ C C K K P D C C + C +CP S+ K ++ + C CH +C +GC G I +C LD+ PL + I G IV ++L + VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ ++ G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +++ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L+ T +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP
Sbjct: 283 KNNREPRECSKEQKICDPLCSEAG---CWGP----GPDQCLSCK--YFSRGK---TCVKSCNL-YYG------DVREF--ANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDCVG------ILDRT---------PLIAAGLI-GGLFVIVIIAL--------------------------------GVAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GAAPNQAQLRILKETEL---KRVKILGAGAFGMVYKGIW-VPEGETV---------KIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLD-TDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSP 783 HSP 2 Score: 110.923 bits (276), Expect = 8.715e-24 Identity = 117/431 (27.15%), Postives = 177/431 (41.07%), Query Frame = 2
Query: 836 CCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFK---NKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELE--GGFSYFKD--NHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLC-YMNIPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC K+CP + +++ CV C + N++ CI C ++C D + ++A D +N + + NC KI G ++ F+ I +M + + LN + + GF + ++ +L NL L+S I L ++ S L +SL+EI+ G N +LC Y + LF+ I P C+ KIC CSE GCWGPG C C+ + TCV C+ +Y + + C+ C +C TC GP P+ C+K C + ++ CV C Y N+ C PCHPNC++ CTGP
Sbjct: 24 CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCT-DICPKVCDGIGTGSLQMAQTVDSSN--------IEKFVNCTKINGNLI-----FLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITS------LQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNL---YYGDVR-EFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVK-CLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNE--CHPCHPNCTQG----CTGP 423 HSP 3 Score: 61.6178 bits (148), Expect = 9.876e-9 Identity = 68/257 (26.46%), Postives = 105/257 (40.86%), Query Frame = 2
Query: 263 NCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSECTTC------------RYINGEEQGCCNDQCLGG------CNGGGASKCTACKNMLNEKKCVELC 937
NCT I G++ L GI L+ +R F ++ EI G L ++ N + F NL I G R+L ++ SL++ + L F+SLR I+A NV +N ++ + ++ W LF + L K+ +CS + K+ ++ CWGP +QC KY S TC + NG C+ QC C+G G C C ++ + CVE C
Sbjct: 153 NCTKINGNLIFLITGIKGDMFHGIRALDP-DRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGG-----RSL----YSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFY-STVNWTSLFRTSTQRALI-----KNNREPRECSKEQKICDPLCSEAGCWGPGPDQC-----LSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKC 388
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 265.003 bits (676), Expect = 2.853e-71 Identity = 195/587 (33.22%), Postives = 288/587 (49.06%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTC--HEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKS-----PKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
P S+ + C P CS + C GP G C C+ R +CV++C + G D+ F G TC+ C C K + KS P D C C + C +CP S+ K ++ + C CH +C +GC G I +C LD+ PL + I G V + + A K K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ ++ G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +++ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++LE T +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP
Sbjct: 492 PRECSQQRMVCDPLCS---VSGCWGP----GPNQCLSCKYFSRGR-----TCVRSCNLYNG---------DVREF--ANGSTCVECDSQCEKAEDKSLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQGCTGPRIQDCIG------ILDRT---------PLIAAGVI---GGMFVVVIVALGFAIFFRRKSIK------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGTGAFGTVYKGIW-VPEGETV---------KIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLE-TNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSP 987 HSP 2 Score: 163.31 bits (412), Expect = 8.361e-40 Identity = 174/663 (26.24%), Postives = 275/663 (41.48%), Query Frame = 2
Query: 170 GTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNH---CIKCY---GNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELEGGFSYFK----DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLC-YMNIPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
G +C + ++ +L ++ K L +NC + G++ I I + R L+F SI E+ G++++ N + + +NLRIIRG + +G ++ ++ G L L R+L I V D N K+L H+ I W ++ +P++++L P+ R +C C CWGP +QCQ +T+C + C N CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC K+CP + +++ CV C + + N+ CI+C MC D + + A D +N + + NC KI G ++ F+ I +M + E LN + + Y ++ +L+ NL+ L+S I L ++ S L +SL+EI+ G N +LC Y + LF+ I P C+ + +C CS GCWGPG C C+ + TCV C+ YN + C+ C +C TC GP P+ C+K C + ++ CV C YP N+ C PCHPNC++ CTGP
Sbjct: 24 GQSVCPGTDNKLSTLSDLDQQYKTLRKFY-ENCEVVMGNLEITSI----ERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK------LYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVDQN---KFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTCR-RCHRSCN-------GRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSN-----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIKMCIQCTEICPKMC--DGIGTGSLQSAQTVDSSN--------IEKFVNCTKINGNLI-----FLITGIKGDMYHGIRALDPERLNVFRTVREITGYLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWITS------LQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQKAKIKDNRDPRECSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCN----LYNGDVREFANGSTCVECDSQCEKAEDKSLTCHGPGPDHCVK-CLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNE--CHPCHPNCTQG----CTGP 627
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 255.373 bits (651), Expect = 2.933e-71 Identity = 133/309 (43.04%), Postives = 197/309 (63.75%), Query Frame = 2
Query: 2723 PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ ++ G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +++ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++LE T +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP
Sbjct: 12 PNQAQLRILKETEL---KRVKILGTGAFGTVYKGIW-VPEGETV---------KIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLE-TNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSP 305
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 264.618 bits (675), Expect = 3.437e-71 Identity = 202/597 (33.84%), Postives = 294/597 (49.25%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKS-----PKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
KN P SK C P CSE C GP G C C+ SR +CVK+C+ Y D+ F G C+ C C K K P D C C + C +CP S+ K ++ + C CH +C +GC G I +C LD+ PL + I G IV ++L + VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ ++ G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +++ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L+ T +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+
Sbjct: 461 KNNREPRECSKEQKICDPLCSEAG---CWGP----GPDQCLSCK--YFSRGK---TCVKSCNL-YYG------DVREF--ANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDCVG------ILDRT---------PLIAAGLI-GGLFVIVIIAL--------------------------------GVAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GAAPNQAQLRILKETEL---KRVKILGAGAFGMVYKGIW-VPEGETV---------KIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLD-TDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN 962 HSP 2 Score: 157.532 bits (397), Expect = 4.605e-38 Identity = 165/630 (26.19%), Postives = 264/630 (41.90%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELE--GGFSYFKD--NHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLC-YMNIPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
+NC + G++ I I + R L+F SI E+ G++++ N + + +NLRIIRG + +G ++ ++ G L L ++L I V D N K+L H+ I W+++ +P++++L P+ R +C C CWG +QCQ +T+C + C N CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC K+CP + +++ CV C +N++ CI C ++C D + ++A D +N + + NC KI G ++ F+ I +M + + LN + + GF + ++ +L NL L+S I L ++ S L +SL+EI+ G N +LC Y + LF+ I P C+ KIC CSE GCWGPG C C+ + TCV C+ +Y + + C+ C +C TC GP P+ C+K C + ++ CV C + + C PCHPNC++ CTGP
Sbjct: 27 ENCEVVMGNLEITSI----ERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK------LYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQN---KFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTCR-RCHRSCN-------GRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSN-----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCT-DICPKVCDGIGTGSLQMAQTVDSSN--------IEKFVNCTKINGNLI-----FLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITS------LQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNL---YYGDVR-EFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVK-CLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQG----CTGP 601
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 264.618 bits (675), Expect = 2.625e-71 Identity = 211/647 (32.61%), Postives = 303/647 (46.83%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCK-GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFT 3778
P N + + C P CS C GP G C C SR SCV++C N SR + V G C+ C C K C G P D C C C +CP S+ K D C CH +C GC T +C LW L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GV LS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP +C++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F
Sbjct: 468 PENCTAEGMVCDPLCSNAG---CWGP----GANQCLSCR--YFSRGK---SCVRSC--------NLYKGESREF-VNGSVCVMCDSQCEKMEDSIVTCYGPGP--DHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCNNPTSHDC-----------------------------------------LWNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLG-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRNQFV 1021 HSP 2 Score: 156.762 bits (395), Expect = 9.746e-38 Identity = 172/656 (26.22%), Postives = 274/656 (41.77%), Query Frame = 2
Query: 176 IICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLN---KLQELEGGFSYFK-DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
++C ++ SL ++ K L +NC + G+ L IT +E R L+F SI E+ G++++ N + + +NLRIIRG I ++L + GN L +L R+L I V N + Y +I W ++ P A ++ + +C C CWGPS CQ+ +T+C + C Y++ CC+ +C GGC G + C +C + CV C P Y+ N + +Y G FC +CP + +++ CV C + + N C C G +C D + + A D +N + + NC KI G ++V D HNI + + LN ++E+ G + ++ +L+ NL+ L+S I L + + L L +SLKEI+ G N+ LCY + + LF+ I P NCT + +C CS GCWGPG C CR + +CV C+ KG + ++ C+ C +C + TC GP P+ C K C N ++ CV C + + ++ K C PCHPNC++ C P+S
Sbjct: 9 VMCAGTENKLSSLSDLEQQYKALRKYY-ENCEVVMGN---LEITSIEPG-RNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG--------IKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYA-DTIHWQDIVRTPNATLV--------PMSSGRCPKSC-------MGRCWGPSDQHCQRLTKTVCAEQCDGRCYG-SYVSD----CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAG-ICPKVCDGIGTGSLQSAQTVDSSN--------IDKFINCTKINGNLHFLVTGIDGDPYHNIAA-LEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLL------ILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE----SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTK-CSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDG----CNNPTS 605
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 264.233 bits (674), Expect = 3.386e-71 Identity = 211/647 (32.61%), Postives = 303/647 (46.83%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCK-GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFT 3778
P N + + C P CS C GP G C C SR SCV++C N SR + V G C+ C C K C G P D C C C +CP S+ K D C CH +C GC T +C LW L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GV LS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP +C++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F
Sbjct: 463 PENCTAEGMVCDPLCSNAG---CWGP----GANQCLSCR--YFSRGK---SCVRSC--------NLYKGESREF-VNGSVCVMCDSQCEKMEDSIVTCYGPGP--DHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCNNPTSHDC-----------------------------------------LWNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLG-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRNQFV 1016 HSP 2 Score: 155.606 bits (392), Expect = 2.141e-37 Identity = 172/655 (26.26%), Postives = 273/655 (41.68%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLN---KLQELEGGFSYFK-DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ K L +NC + G+ L IT +E R L+F SI E+ G++++ N + + +NLRIIRG I ++L + GN L +L R+L I V N + Y +I W ++ P A ++ + +C C CWGPS CQ+ +T+C + C Y++ CC+ +C GGC G + C +C + CV C P Y+ N + +Y G FC +CP + +++ CV C + + N C C G +C D + + A D +N + + NC KI G ++V D HNI + + LN ++E+ G + ++ +L+ NL+ L+S I L + + L L +SLKEI+ G N+ LCY + + LF+ I P NCT + +C CS GCWGPG C CR + +CV C+ KG + ++ C+ C +C + TC GP P+ C K C N ++ CV C + + ++ K C PCHPNC++ C P+S
Sbjct: 5 LCAGTENKLSSLSDLEQQYKALRKYY-ENCEVVMGN---LEITSIEPG-RNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG--------IKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYA-DTIHWQDIVRTPNATLV--------PMSSGRCPKSC-------MGRCWGPSDQHCQRLTKTVCAEQCDGRCYG-SYVSD----CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAG-ICPKVCDGIGTGSLQSAQTVDSSN--------IDKFINCTKINGNLHFLVTGIDGDPYHNIAA-LEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLL------ILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE----SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTK-CSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDG----CNNPTS 600
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 264.233 bits (674), Expect = 3.879e-71 Identity = 211/647 (32.61%), Postives = 303/647 (46.83%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCK-GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFT 3778
P N + + C P CS C GP G C C SR SCV++C N SR + V G C+ C C K C G P D C C C +CP S+ K D C CH +C GC T +C LW L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GV LS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP +C++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F
Sbjct: 494 PENCTAEGMVCDPLCSNAG---CWGP----GANQCLSCR--YFSRGK---SCVRSC--------NLYKGESREF-VNGSVCVMCDSQCEKMEDSIVTCYGPGP--DHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCNNPTSHDC-----------------------------------------LWNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLG-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRNQFV 1047 HSP 2 Score: 156.377 bits (394), Expect = 1.393e-37 Identity = 172/655 (26.26%), Postives = 273/655 (41.68%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLN---KLQELEGGFSYFK-DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ K L +NC + G+ L IT +E R L+F SI E+ G++++ N + + +NLRIIRG I ++L + GN L +L R+L I V N + Y +I W ++ P A ++ + +C C CWGPS CQ+ +T+C + C Y++ CC+ +C GGC G + C +C + CV C P Y+ N + +Y G FC +CP + +++ CV C + + N C C G +C D + + A D +N + + NC KI G ++V D HNI + + LN ++E+ G + ++ +L+ NL+ L+S I L + + L L +SLKEI+ G N+ LCY + + LF+ I P NCT + +C CS GCWGPG C CR + +CV C+ KG + ++ C+ C +C + TC GP P+ C K C N ++ CV C + + ++ K C PCHPNC++ C P+S
Sbjct: 36 VCAGTENKLSSLSDLEQQYKALRKYY-ENCEVVMGN---LEITSIEPG-RNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG--------IKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYA-DTIHWQDIVRTPNATLV--------PMSSGRCPKSC-------MGRCWGPSDQHCQRLTKTVCAEQCDGRCYG-SYVSD----CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAG-ICPKVCDGIGTGSLQSAQTVDSSN--------IDKFINCTKINGNLHFLVTGIDGDPYHNIAA-LEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLL------ILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKG----ESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTK-CSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDG----CNNPTS 631
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 262.307 bits (669), Expect = 5.750e-71 Identity = 208/642 (32.40%), Postives = 301/642 (46.88%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCK-GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRD 3763
P N + + C P CS C GP G C C + SCV++C N SR + V G C+ C C K C G P D C C C +CP S+ K D C CH +C GC T +C LW L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GV LS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP +C++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID +
Sbjct: 314 PENCTAEGMVCDPLCSNAG---CWGP----GANQCLSCRYFSRGK-----SCVRSC--------NLYKGESREF-VNGSVCVMCDSQCEKMEDSIVTCYGPGP--DHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCNNPTSHDC-----------------------------------------LWNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLG-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSN 862 HSP 2 Score: 126.331 bits (316), Expect = 2.140e-28 Identity = 127/464 (27.37%), Postives = 197/464 (42.46%), Query Frame = 2
Query: 731 CWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLN---KLQELEGGFSYFK-DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
CWGPS CQ+ +T+C + C Y++ CC+ +C GGC G + C +C + CV C P Y+ N + +Y G FC +CP + +++ CV C + + N C C G +C D + + A D +N + + NC KI G ++V D HNI + + LN ++E+ G + ++ +L+ NL+ L+S I L + + L L +SLKEI+ G N+ LCY + + LF+ I P NCT + +C CS GCWGPG C CR + +CV C+ KG + ++ C+ C +C + TC GP P+ C K C N ++ CV C + + ++ K C PCHPNC++ C P+S
Sbjct: 18 CWGPSDQHCQRLTKTVCAEQCDGRCYG-SYVSD----CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAG-ICPKVCDGIGTGSLQSAQTVDSSN--------IDKFINCTKINGNLHFLVTGIDGDPYHNIAA-LEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLL------ILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE----SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTK-CSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDG----CNNPTS 451 HSP 3 Score: 67.781 bits (164), Expect = 1.670e-10 Identity = 74/281 (26.33%), Postives = 115/281 (40.93%), Query Frame = 2
Query: 191 DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANF-TQVFCWGPSANQCQQQTLCGSKYSSECTTC------------RYINGEEQGCCNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
D + SL S+ + + +I + NCT I G+++ L I LE ++ + F ++ EI G L I+ N + F NL I G R L ++ SL++ L L F+SL+ I+A NV N + Y H++ W LF + T ++ + C+ + + + CWGP ANQC +Y S +C ++NG C+ QC + C G G CT C N + CVE C
Sbjct: 156 DGIGTGSLQSA-QTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFF-TVREITGFLNIQSWPRNMTDLSVFSNLVNIGG-----RVL----YSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYY-HTVNWTSLFRTSNQR-----TTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQC-----LSCRYFSRGKSCVRSCNLYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKC 414
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 263.077 bits (671), Expect = 8.092e-71 Identity = 210/642 (32.71%), Postives = 302/642 (47.04%), Query Frame = 2
Query: 1925 PLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSCK-GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRD 3763
P N + + C P CS C GP G C C SR SCV++C N SR + V G C+ C C K C G P D C C C +CP S+ K D C CH +C GC T +C LW L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GV LS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP +C++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID +
Sbjct: 467 PENCTAEGMVCDPLCSNAG---CWGP----GANQCLSCR--YFSRGK---SCVRSC--------NLYKGESREF-VNGSVCVMCDSQCEKMEDSIVTCYGPGP--DHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCNNPTSHDC-----------------------------------------LWNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLG-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSN 1015 HSP 2 Score: 156.377 bits (394), Expect = 1.244e-37 Identity = 172/656 (26.22%), Postives = 273/656 (41.62%), Query Frame = 2
Query: 176 IICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLN---KLQELEGGFSYFK-DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ K L +NC + G+ L IT +E R L+F SI E+ G++++ N + + +NLRIIRG I ++L + GN L +L R+L I V N + Y +I W ++ P A ++ + +C C CWGPS CQ+ +T+C + C Y++ CC+ +C GGC G + C +C + CV C P Y+ N + +Y G FC +CP + +++ CV C + + N C C G +C D + + A D +N + + NC KI G ++V D HNI + + LN ++E+ G + ++ +L+ NL+ L+S I L + + L L +SLKEI+ G N+ LCY + + LF+ I P NCT + +C CS GCWGPG C CR + +CV C+ KG + ++ C+ C +C + TC GP P+ C K C N ++ CV C + + ++ K C PCHPNC++ C P+S
Sbjct: 8 FVCAGTENKLSSLSDLEQQYKALRKYY-ENCEVVMGN---LEITSIEPG-RNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG--------IKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYA-DTIHWQDIVRTPNATLV--------PMSSGRCPKSC-------MGRCWGPSDQHCQRLTKTVCAEQCDGRCYG-SYVSD----CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAG-ICPKVCDGIGTGSLQSAQTVDSSN--------IDKFINCTKINGNLHFLVTGIDGDPYHNIAA-LEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLL------ILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE----SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTK-CSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDG----CNNPTS 604
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 269.24 bits (687), Expect = 8.618e-73 Identity = 197/596 (33.05%), Postives = 290/596 (48.66%), Query Frame = 2
Query: 2156 GFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRT 3856
G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID + F + ++ P+P R+ T
Sbjct: 549 GSICVECDSQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRNQFV----YQDGGFATQQGMPMPYRATTST 1071 HSP 2 Score: 145.591 bits (366), Expect = 2.169e-34 Identity = 159/665 (23.91%), Postives = 259/665 (38.95%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F SI E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W + I+ +P + ++ S C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + S PN+ + F+ + + + L +SLKEI+ G N LCY + I LF + I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C +C L TC GP P+ C K C + ++ CV C + + + C PCHPNC++ C GP+S
Sbjct: 28 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQD--------IVRNPWPSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLN--------------------IQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG----CNGPTS 630 HSP 3 Score: 62.7734 bits (151), Expect = 3.867e-9 Identity = 81/294 (27.55%), Postives = 126/294 (42.86%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL--GI-----TKLESKERE-LN-FDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRD-KCSDQCKLWANFTQVFC-----WGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L GI +++ + E LN F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ T+ + +++RD + ++ C C WGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 325 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQC----LSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 593
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 264.233 bits (674), Expect = 3.637e-71 Identity = 192/565 (33.98%), Postives = 280/565 (49.56%), Query Frame = 2
Query: 2156 GFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRD 3763
G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID +
Sbjct: 549 GSICVECDSQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSN 1044 HSP 2 Score: 144.821 bits (364), Expect = 3.981e-34 Identity = 159/665 (23.91%), Postives = 259/665 (38.95%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F SI E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W + I+ +P + ++ S C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + S PN+ + F+ + + + L +SLKEI+ G N LCY + I LF + I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C +C L TC GP P+ C K C + ++ CV C + + + C PCHPNC++ C GP+S
Sbjct: 28 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQD--------IVRNPWPSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLN--------------------IQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG----CNGPTS 630 HSP 3 Score: 62.7734 bits (151), Expect = 4.328e-9 Identity = 81/294 (27.55%), Postives = 126/294 (42.86%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL--GI-----TKLESKERE-LN-FDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRD-KCSDQCKLWANFTQVFC-----WGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L GI +++ + E LN F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ T+ + +++RD + ++ C C WGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 325 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQC----LSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 593
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]) HSP 1 Score: 249.21 bits (635), Expect = 1.085e-66 Identity = 174/520 (33.46%), Postives = 265/520 (50.96%), Query Frame = 2
Query: 2174 CPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCK------GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEE----IEKGSGDIVC------------------LSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
C LCS P+ +C C+ V C +C E + +++ S C CH C C G NC +C + Y+D +C TCP E + + VC +W S K+ +V L+ +++V + I ++++R+ I + + L EP + + PN L I+ + + + K LG GAFG VYKG W IP+ E+ +PVAIK ++ + + + ++ EA +MASV + H R +G+CL+ LI+ + G L ++ +K+ I S +L+W QIA GM YL R ++HRDLAARNVLV + V+ITDFGL+K+L ++KE + GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ DI + KG RL QP IC++DVY+IMV CW+ + RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 506 CNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVEN-SECIQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGP--HCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIA------TGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPS----GEAPNQAHLRILKETEF---KKIKVLGSGAFGTVYKGLW-IPEGEKV---------KIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSP 994 HSP 2 Score: 150.214 bits (378), Expect = 7.812e-36 Identity = 170/661 (25.72%), Postives = 272/661 (41.15%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRS-KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGN-----AHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPA-MMLPENTGCVHKCSEGYFKNKSN---HCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG-----YIVLTEDSFVKHNITVEMLYENLNKLQELEGGF--SYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDK-------ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN-----TCVGPNPNQCIKGCKNKRENGTCVASCSKNF--------YPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGC 2029
+CQ + ++ L + + LS+ R NC + G++ I + + +L+F +I+E+ G+++I N +E+I +NL+IIRG N++ N ++L + N L +L R+L+ I V F +NP + + +I+W ++ Q +F ++ DL +C + CWG CQ+ T +C + S C CC++QC GC G S C C+ +E C + C Y+ N E +Y G C K+CP ++ ++ CV C Y++ + + C KC G CN I D + A ++ K C I G + DSF + E L ++E+ G + DN F + H A+ + LGL+SLKEI +G N+ LCY N I +LF I +N +K +C+ CS +GCWGP + C C+ CV C+ +G P + N +C++CHPECL TC G P+ CI+ C + + CV +C + + + C CH NC+ Y C G PG+ GC
Sbjct: 30 VCQGTSNRLTQLGTFEDHF--LSLQRMYNNCEVVLGNLEITYV----QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRG-NALYEN-------TYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNM-DTIQWRDI-----VQNVFMSNMSMDLQSHPSSCPKCD--PSCPNGSCWGGGEENCQKLTKIICAQQCSHRCR-----GRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPC----RKVCNGIGIGEFKD---TLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQF-------SLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEG--EP--REFVENSECIQCHPECLPQAMNITCTGRGPDNCIQ-CAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCT-YG---CAG----PGLQGC 636
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410]) HSP 1 Score: 227.254 bits (578), Expect = 1.110e-59 Identity = 120/308 (38.96%), Postives = 186/308 (60.39%), Query Frame = 2
Query: 2723 PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIK-NMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSP 3643
PN ++ I+ + +L + K LG GAFG VYKG W IP E + +PVAIKV++ N + + ++ EA +MA V + R +G+CL+ L++ + G L + ++ ++ S +L+W QIA GM YL + ++HRDLAARNVLV V+ITDFGL+++L+ + E GKVPI+W+A+E++ +++H++DVW+YGVT+WE+ TFG PY+ +I D + KG RL QP IC++DVY+IMV CW+ RP F+ L+ F+ ++P R++ IQ + SP
Sbjct: 708 PNQAQMRILKETEL---RKLKVLGSGAFGTVYKGIW-IPDGE---------NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQ-LVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD-IDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSP 1000 HSP 2 Score: 142.51 bits (358), Expect = 1.954e-33 Identity = 155/651 (23.81%), Postives = 257/651 (39.48%), Query Frame = 2
Query: 170 GTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIK----------RNLIDKGHTDFSLVVSGNA--HLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRG--PYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTG-CVHKC----SEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLR------AQDLVQLKNCKKILGYIVLTEDSFVKH--NITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDK-------ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECL-----NTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPL---------NDSKACLPCHPNCS 1972
GT +C ++++ S L +L + + C +QG+ L +T L + I+E+ G+++I N ++ + + LRI+RG + R+ +D + + G L +L RSL I V+ NP++ Y + W ++ Q+ T C+ CK CWG S CQ L G+ +S C C+ CC++QC GC G S C AC + + C C Y+ ++ N E RY G C CP L G C C E ++ + C KC PC AG G +LR + ++ + CKKI G + +SF + + + E+L + LE Y + ++ + + + + + + LGL+SL+E+ +G +N LC++N +P ++LF+N N ++ +C+ C+ CWGPG C C ++ CV +C KG + + + CL CHPEC TC G +QC + C + +++ +CVA C P L ++ C PC NC+
Sbjct: 22 GTQVCTGTDMKLRLPASPETHLDMLRHLY-QGCQVVQGN---LELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLD----NVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQ-DMVLWKDVLRK-NNQLAPVDMDTNRSRACPPCAPTCK------DNHCWGESPEDCQ--ILTGTICTSGCARCK--GRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSK--------PC-----AGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHD--GAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKG----LPREYVRGKHCLPCHPECQPQNSSETCYGSEADQC-EACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCT 632
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411]) HSP 1 Score: 227.254 bits (578), Expect = 1.576e-59 Identity = 110/279 (39.43%), Postives = 171/279 (61.29%), Query Frame = 2
Query: 2783 KPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKN-MGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQ 3616
K LG G FG V+KG W IP+ E +PV IKVI++ G + ++V + S+ H H +R +G+C L++ Y+ GSL + +++ + ++L+W QIA GM YL + +++HRDLA RNV++ VQ+ DFG++ +L DK+++ K PI+W+A+E++ GKY+H++DVW+YGVT+WE+ TFG PY +I D + KG RL+QP IC++DVY++MV CW+ N+RP F+ L FT ++P RYL I+
Sbjct: 711 KVLGSGVFGTVHKGIW-IPEGE---------SIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQ-LVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLL-PPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIK 977 HSP 2 Score: 146.747 bits (369), Expect = 9.448e-35 Identity = 153/619 (24.72%), Postives = 236/619 (38.13%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLV---VSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQ--QQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILG---YIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCY---------MNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC-----LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
+ C + G++ I+ L +L+F I E+ G++++ N+ + NLR++RG + D F ++ + + L L F L I V + N K+ ++ +I W ++ P A+I+ V + C + CK CWGP CQ +T+C + + C CC+D+C GGC+G + C AC++ + CV C P Y+ N +Y G C CP + + T CV C KN C C G +C G G+ + + ++ NC KILG +++ + H I + E LN + + Y ++ + N + + + LG +SLKEI+ G NQ+LCY + P E N K+C CS GCWGPG C CR Y G CV+ C+ +G P + C CHPEC +TC G + C + C + R+ CV SC YP + C PCH NC++ C GP
Sbjct: 54 EKCEVVMGNLEIV----LTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQ-----VYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHM-DTIDWRDIVRVPDAEIV----VKNNGGNCPPCHEVCK-------GRCWGPGPEDCQILTKTICAPQCNGRC-----FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRG-LCPK--------ACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPA-LDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNR-GFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQG--EP--REFVHEAHCFSCHPECQPMEGTSTCNGSGSDACAR-CAHFRDGPHCVNSCPHGILGAKGPIYKYP--DAQNECRPCHENCTQG----CKGP 624
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3) HSP 1 Score: 432.18 bits (1110), Expect = 5.887e-126 Identity = 344/1184 (29.05%), Postives = 551/1184 (46.54%), Query Frame = 2
Query: 254 RSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF-----VKHNITVEMLY--------ENLNKLQELEG------------GFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYM-NIPVNELFKNVKNFYYIPSNCTDKICHKD-------CSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCV---KTCHEG---TYAFPNDRPDISRFYPVTG-FTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKI--------YLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMG----RLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIK-VIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPY 3628
R NCT++ G+ L +T L ++ +L+F D+I E+ G+++I D++K+ F L+IIRG ++ ++ ++L V+ + + L+ LR + V F +N + ++ +I+W+E+ ++ ++ T KC + C CWG CQ+ + C S +C R + + CC+ C GGC G C ACKN +E E C Y+ TN E +Y G C K+CP +L +N CV C + +K C+ C G PC G T L A ++ +NC I G I + + +F V N T+ Y E + ++E+ G SYF++ +H + AI ++ L L +++LK+I+ G N+ LCY+ NI + K + ++ N +C K+ C+E GCWG G C C+ ++ GTC++DC G+ + N+ N+ C CHPEC TC G + C + C + R+ CV+ C KN Y ND C CH C CTGP GIG C C +++ A + C+ C +G Y P ++ + P+ G C C LC C C C + C CP D + + C H C GC G +C C+N K+ Y++ F C CP + + C + +K+ ++ + +L+ I ++ + ++K A++ ++ S +D + L +P N+G +L IV +L + LG GAFG VYKG W +P+ E + +PVAIK ++K+ G E E ++EA +MAS H++ L+ + VC+S + LI+ + G L ++ N++KI S +L+WS QIA GM YL ++ ++HRDLAARNVLV V+ITDFGL+K+L S+ E GK+PI+WLA+E + + ++ ++DVWA+GVT+WE+ TFG+ P+E+ DI D + G +L QP+ICSLD+Y +++CW +RP F+ L F ++ ++PGRYL+I GD +
Sbjct: 125 RYTNCTYVDGN---LKLTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEE---KYALFVT-YSKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSN-GTDAYYNYDFTAPERECPKCHESCTHG-------CWGEGPKNCQKFSKLTC----SPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM-DKGGECVPCNG--------PCPK-TCPGVT------VLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRN----------------LETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYIS--NAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKY---NDRGVCRECHATCDG-----CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLK---PLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSG-----CEDSEPL-RPSNIGANLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGE---------NVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLL-SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKF 1212
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1) HSP 1 Score: 417.542 bits (1072), Expect = 9.912e-122 Identity = 313/1056 (29.64%), Postives = 487/1056 (46.12%), Query Frame = 2
Query: 593 HSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF-----VKHNITVEMLYENLN--------KLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCY-MNIPVNELFKNVKNFYYIPSNCTDKICHKD-------CSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVK---TCHEGTYAFPNDRPDISRFYPVTG-FTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKK------KFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKP----PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKN-MGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPY-EIPS 3640
+I W E+ T P A + T C C + CWG CQ+ + + S +C R + CC+ C GGC G S C ACKN ++ C + C Y+ N + +Y G C ++CP +L +N CV C K + C+ C G PC G + + ++ K+C I G I + + SF V N + YE ++ L+E+ G + D+ L ++ + + +T L GL SLK+I +G +N+ LCY +I + K+ ++ + +N + C KD CS++GCWGPG C C+ + C+ DC+ G Y + C CH EC +C+GPN + C K CK+ R+ CV C + Y ND+ C CH NC C GP + G GC+ C++ +L+ C++ +C +G Y + P+ C C C KC G C+ C C CP D D+ C C S C+GC+G C +C+N KIY+D+ F C +TC P + S L A L E + + V + ++V I+ + + +A A+ ++ + L D++ +P PN+ +L I+ +E++ + LG+GAFG VYKG W +P+ E + +PVAIKV+ + G + + EA +MASV H + L+ + VC++ + L++ + G L F+ R K+KI S +L+W QIA GM YL +R ++HRDLAARNVLV CV+ITDFGL+K+L+ +++ GK+PI+WLA+E + ++H++DVWA+GVT+WE+ T+G PYE+ ++ + + KG RL QP IC++DVY+IM+ CW+ RP F+ L + F ++PGRYL+I+GD Y +PS
Sbjct: 11 RTINWEEIITGPSAMYSYVYNFTSPERACTPCDKSC-------EQGCWGEGPENCQKYS--KTNCSPQCWQGRCFGPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCPPKK-KALNGECVPCDG--------PC-----PKTCKGVEKVH--SGNIDSFKDCTIIEGSITILDQSFQGFQHVYRNFSFGKRYEKMHPDKLEVFSTLKEITGFLNIQGDHKDFKNLSYFRNLEVIGGRTLTEY-----FASLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDEGCWGPGPAQCLSCKNFILGNDCLQDCT-APGIYQ------ADEKTCKVCHEECDGSCIGPNTDHC-KKCKHARDGPFCVPECPASKY---NDNGVCKSCHGNCV----GGCEGPENNIGPNGCHSCDKAILNDHVP-EGCLQKKESCPDGYYYEWVSPLEQGPLKPLASKAVCRKCHSRCKKCTGYGFHEHVCQECTKYKRGEQCEDECPAD-----YFADANKLCIPCFSECRGCFGPGPNQCYKCRNYKIYIDEDTDGNTTSFNCTETCTPEYPHKIFNPDSEPYCSLE----TAGLIENELQPAILAGVAVFALAFLVVAAIIMYFWRVRAKAKENTVKMTMALTGL------DDNEPLRPTGVKPNLAKLRIIKEEEM---RKGGILGYGAFGNVYKGVW-VPEGE---------NVKIPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMTSQM-MLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLLD-INEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFGVTIWEVLTYGGRPYENVPARNVPELLEKGERLPQPAICTIDVYMIMIKCWMLDAESRPSFKELAEDFAKMSRDPGRYLAIKGDKYMRLPS 990 HSP 2 Score: 67.781 bits (164), Expect = 9.222e-10 Identity = 69/266 (25.94%), Postives = 114/266 (42.86%), Query Frame = 2
Query: 221 SVEKLKILSIIRSKNCTHIQGSIYILGIT------------------KLESKERELNFDSIEEIDGHLIIEGN--DLEKIT-FKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK--CSDQCKLWANFTQVFCWGPSANQCQ--QQTLCGSKYSSECTTCRYINGEEQGC--CNDQCLGGCNGGGASKCTACKNMLNEKKCVELC 937
VEK+ +I K+CT I+GSI IL + K+ + E+ F +++EI G L I+G+ D + ++ F+NL +I G R L + F+ + LV SL+ I + ++ N + Y SI W + + + L S + ++D C +QC + CWGP QC + + G+ +CT +E+ C C+++C G C G C CK+ + CV C
Sbjct: 186 GVEKVHSGNIDSFKDCTIIEGSITILDQSFQGFQHVYRNFSFGKRYEKMHPDKLEV-FSTLKEITGFLNIQGDHKDFKNLSYFRNLEVIGG-----RTLTEY----FASLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYA-QSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQC------SDEGCWGPGPAQCLSCKNFILGNDCLQDCTAPGIYQADEKTCKVCHEECDGSCIGPNTDHCKKCKHARDGPFCVPEC 434
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P24348|LET23_CAEEL (Receptor tyrosine-protein kinase let-23 OS=Caenorhabditis elegans OX=6239 GN=let-23 PE=1 SV=3) HSP 1 Score: 416.001 bits (1068), Expect = 6.062e-121 Identity = 339/1136 (29.84%), Postives = 526/1136 (46.30%), Query Frame = 2
Query: 338 FDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQ-GCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKS---NHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNI----TVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYM-----NIPVNELFKNVKNFYYIPSN-------CTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGT-------CVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPD--ISRF--YPVTGFTCLPCPELCSKCK--GKSPKNDECEVCKGVWHK-----NTCRLRCPRDESYGTKIIDSISYCKTCHSSCKG---CYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
FD++EEI G LII +++KI+F LR+I G D+ D +L + N + ++ R LR I +V NPKM Y+ I W EL DP Q + + + K +C N CWG N CQ+ +++C C+ C Y N CC+ CLGGC G G C AC + C+E C R ++ G + N + RY G C K+CP +L EN CV CS+G+ + + C KC + C + + GH L + L L+ C++I G++++ E +F + TV+++ E + +Q+ + K+ L LH+ L Y +LE L L SLK I G KN +LCY+ + + K+ K I N ++C K+C+++GCWG + C EC+ + + GTCV C K N ++ KC RC PEC TC G C+ C++K + CV C + +P C CHP C + CTGP S G GGC +C + + + D + C+++ ND P+ IS + V C C C C G++ ++C VCK V ++ C +CP + +++ CK CH C C C +CKN ++ C CP K++ +G+ CL + +R V + + ++ + ++VY + + I ++++ LT ++ S PNM R+ ++ +L + + K LG GAFG V+ G + K + + +PVAIKV + + + +++EA M + H + L+ IG C+ + +++ Y G+L FL +K + + + + QIA GM YL K+ ++HRDLA RNVLV + V+ITDFGLSK+L+ D I IK+GKV I+WLAIE + Y+H +DVWA+GVT WEI TFG+ PY+ +T I +F+ G RLSQP CS D+Y ++ CW+ P RP F+ L + F ++CK P +L
Sbjct: 109 FDNLEEIRGSLIIYRANIQKISFPRLRVIYG---------DEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDK---CWGSGDNDCQRVYRSVC----PKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCP------KICTVDGH--------LTNETLKNLEGCEQIDGHLII-EHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKN-----------LQIIEGRKLHNVRWALAIYQC-----DDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQ------TSMKCERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFP--TQKNVCEKCHPTCYDNG---CTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTV--CKKCHHECDQNYHCANGQSTGCQKCKNFTVF-KGDIAQCVSECP--KNLPFSNPANGE--CLDY-----DIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDA------SVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIY---------YPKRAKNVKIPVAIKVFQT-DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDAD-SITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL 1152
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q62956|ERBB4_RAT (Receptor tyrosine-protein kinase erbB-4 OS=Rattus norvegicus OX=10116 GN=Erbb4 PE=1 SV=3) HSP 1 Score: 267.314 bits (682), Expect = 2.669e-71 Identity = 194/565 (34.34%), Postives = 281/565 (49.73%), Query Frame = 2
Query: 2156 GFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPR----DESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAER------IETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETML---------PLLNGRDSIDRD 3763
G C+ C C K C G P D C C C +CP S+ K D C CH +C +GC G T +C IY W + L + RT + V+ L +++I+ +T VY++RK+I ++ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MASV H H +R +GVCLS L++ + G L +++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++LE +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVYI+MV CW+ + RP F+ L F+ ++P RYL IQGD ++PSP+ + F N E+ M AE L P+ R ID +
Sbjct: 549 GSICVECDSQCEKMEDGLLTCHGPGP--DNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDC-------IYYP-------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYIVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF--FQNLLDEEDLE-DMMDAEEYLVPQAFNIPPPIYTSRTRIDSN 1044 HSP 2 Score: 143.665 bits (361), Expect = 5.448e-33 Identity = 160/666 (24.02%), Postives = 261/666 (39.19%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDP-KAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHA----GFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTN------DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV--LTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA------------------ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASC-------SKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSS 2008
+C ++ SL ++ + L +NC + G++ I I R+L+F SI E+ G++++ N + +NLRIIRG + ++ GN L +L ++L I V D N + Y +I W ++ +P + + T+ R C C CWGP+ N CQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P + T E ++A G FC K+CP + +++ CV C + + N C CT+ D + A D +N + + NC KI G ++ +T +N + E LN + + + + + PN+ + F+ + + + L +SLKEI+ G N LCY + I LF V I NCT + +C+ CS GCWGPG C CR++ C+ C+ G + + + C+ C +C L TC GP P+ C K C + ++ CV C + + + + C PCHPNC++ C GP+S
Sbjct: 28 VCAGTENKLSSLSDLEQQYRALRKYY-ENCEVVMGNLEITSI----EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR--KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYA-DTIHWQDIVRNPWPSNMTLVSTIGSSGCGR--CHKSCT-------GRCWGPTENHCQTLTRTVCAEQCDGRCYG-PYVSD----CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC--PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMC--KPCTDICPKACDGIGTGSLMSAQTVDSSN--------IDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLN--------------------IQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCTK-CSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQG----CNGPTS 630 HSP 3 Score: 62.7734 bits (151), Expect = 2.830e-8 Identity = 78/295 (26.44%), Postives = 123/295 (41.69%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRD-KCSDQCKLWANFTQVFC-----WGPSANQCQQQTLCGSKYSSE---CTTCRYINGE----EQGC----CNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL S+ + + +I + NCT I G++ L I ++ ++ + F ++ EI G L I+ N + F NL I G R L ++ SL++ + L F+SL+ I+A N+ N + Y H+I W LF+ TV + +++RD + ++ C C WGP +QC L ++S +C +GE E G C+ QC L C+G G CT C + + CVE C
Sbjct: 325 PCTDICPKACDGIGTGSLMSA-QTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNV-FRTVREITGFLNIQTWPPNMTDFSVFSNLVTIGG-----RVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY-HTINWTTLFS----------TVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQC----LSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC 593
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P11273|ERBB_AVIEU (Tyrosine-protein kinase transforming protein erbB OS=Avian erythroblastosis virus (strain ts167) OX=103898 GN=V-ERBB PE=3 SV=1) HSP 1 Score: 250.751 bits (639), Expect = 1.796e-70 Identity = 139/345 (40.29%), Postives = 206/345 (59.71%), Query Frame = 2
Query: 2615 YLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
YL+R+ I + + L EP + + PN L I+ + + + K LGFGAFG VYKG W IP+ E+ + PVAIK ++ + + + ++ EA +MASV + H R +G+CL+ LI+ + G L ++ +K+ I S +L+W QIA GM YL +R+++HRDLAARNVLV + V+ITDFGL+K L +KE + GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ +I + KG RL QP IC++DVY+IMV CW+ + RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 87 YLRRRHIVRKRTLRRLLQERELVEPLTPS----GEAPNQAHLRILKETEF---KKVKVLGFGAFGTVYKGLW-IPEGEKVTI---------PVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT-STVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERHMVHRDLAARNVLVKTPQHVKITDFGLAKQL-GADEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMSDADSRPKFRELIAEFSKMARDPPRYLVIQGDERMHLPSP 412
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1B1ACY5 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 2855.86 bits (7402), Expect = 0.000e+0 Identity = 1478/1479 (99.93%), Postives = 1478/1479 (99.93%), Query Frame = 2
Query: 86 MTHKTYXXXXXXXXXXXXNNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSXXXXXXXXXXXXXXXXXXXXXVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNNVXXXXXXXXXXXXDDYLEPNAPGPKNTSLVDTGDPEGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR 4522
MTHKTYLILFLFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSQNPQNLNTRNNNTNNNNTPRLVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNNVSASQSPQISQISDDYLEPNAPG KNTSLVDTGDPEGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR
Sbjct: 1 MTHKTYLILFLFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSQNPQNLNTRNNNTNNNNTPRLVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNNVSASQSPQISQISDDYLEPNAPGSKNTSLVDTGDPEGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR 1479
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1B1ACX9 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 707.983 bits (1826), Expect = 0.000e+0 Identity = 440/1192 (36.91%), Postives = 640/1192 (53.69%), Query Frame = 2
Query: 140 NNATFEEEYPGTIICQNDNVQIESLHSSVEKLKIL--SIIRSKNCTHIQGSIYILGITKLES-KERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQV---FCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMC---TNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSY--FKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDKICHKDCS---EKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKA---CLPCHPNCSEYNSTI-----CTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYP--VTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCK-GCY-GSTIFNCTRCKNKKIYLD--KKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEET---KRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKD--EDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
N + F +YP IC S + E L ++ + CTHI G++ I +++ ++ + +L+F +SI EI G L I ND+++I NL++IRG RN D + + +G L ++D R+LR+I + NVI NP ++YL ++ W+++ DP Q L + KC +C+ W V FC+GPS N+CQ+QT C + + C++ E C + +C GGC+G + CT C ++ + CV C P I G + + RY G C+ QCPA +L +N CV++C + N CI+C C T + CN+ I N Y L Q L+QL NC ILG + + + SF K+ +TV MLY +L ++E+ G FS F+ + H+ + + K+ +EFLGLK LK++ G CY++ IP E+ P N C+K C CWGPGN++CY C Y A +CV CS G++ + + KC CHP C C GP P C C+ E TCV +CS +F+P N+ A C CH +C + + CTGPS++ G GGC+KCE+++ + + +C +G Y ++ +IS + V +C PC +C C G + + C CKG + N C C ++ K+ + C CH C+ GC + CTRC N K+++D K KF C CP ++ E + GD +CL K EET K+ ++ ++ +I V+Y + +A RI E+KA YSN EP+ K+ ED +++PPNM R+ ++ DL+F+ SKPLG GAFG VY+G WK+P+ + + L V IKVI N + ++EAK+MASVSH HCL IGVCLS EKPCL+S Y + GSLDK+L +N KI+S ML W++QIADGM YL KR IIHRDLAARNVLV+ + +QITDFGL+++++ T D I+IK+GKVPIRWLAIETL YS TDVWAYGVTLWEIFT+ K PYE+ AT +I F+ +G RL QP+I +L+VY++M+ CWL+ P++RP F L+ TF + ++P R+L
Sbjct: 17 NGSNFNPDYPNFRICVVSEAH-GSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVT--LRNEPDALNIIHNHSENG-TFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVK--NKDLKWCKFTKTGEIPC-SHECAGGCDGRTSKDCTVCNKLVKDSDCVSSC-APRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKY------IEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEIS---------PDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF--ASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQ-NISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKL-EIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQ--DGDFICL-------KFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYIN-------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDET-DDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 1164
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1B1ACY2 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 671.774 bits (1732), Expect = 0.000e+0 Identity = 433/1202 (36.02%), Postives = 635/1202 (52.83%), Query Frame = 2
Query: 152 FEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSK-------NCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRY--INGE-EQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCY-GNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKH--NITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA---ISETELEFLGLKSLKEINGPFRFFKNQKLCY---MNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQK-------CLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSE--YNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGF-TCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRC-------PRDESYGTKIIDSISYCKTCHSSC-KGCYGS--TIFNCTRCKNKKIYLDK--KKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKP-PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKD--KEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGD 3622
F+EEYPG IC++ S+ S + S++ K NCTH++G++ I + + + +L F SI E+ G + ++ N ++ I NL++IRG NS+ ++K + + + F LR I ++V F + K K+LP SIKW ELF +PK Q L +T + + +C C L +F +CW SAN CQ+Q+ C + C + NGE ++G C++QC GGCNG S C CK +N CVE C + G T N F+ G+ C+ CP +L E C++ C+ +F N CI+C ++C N+ KI + + FY+ A L + + ++G T SF K IT+ MLY++L +Q + G N L +I +L + A I T+LEFLGL+ L+ I G F + LCY +N N L N + Y P N K C C +GCWGPG+ +CY CR + A CV C + GFY N+S + C RCHP CL C GP P CI GC+ +EN CV +CS+ ++ + +K C+ CH C E N +CTG SS+ G+GGC+ C +++ R C Y D ++ + C PC E C +C G CE C G W + C +C PR+ S C C+ +C + C + F C C K++YLD K F C CP + + DI+C++ + + E K ++++++ + +I V I K ++ LKA YSN+ EP+S+ K PNM RL+++ DLIF +KP+G GAFG VY+G WK P N++ L+K+ D L VA+KVI+ N +I+ +M+EAK+MASV H HCLR IG+CL YE PCLI+ +V+ GSLDK+L ++K+ + S +LSW EQIADGM YL R IIHRDLA RNVL++ LE +QITDFGL+ +++ T+D EI+I G+VPIRWLA+ETL +G YSH+TDVW++G+TLWEIFT+G+ PY++ +I ++++G RL+QP+ICS+D+Y +M CW E+ N RP F+ LM T + + + P YL+I D
Sbjct: 23 FDEEYPGVTICES------SMTSGFQYFMPHSLMFLKGELGGNHNCTHVEGNLVIQNVWP-DQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLA---LEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC-LRNDFP--YCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCPVNLLQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAKKEF--NINKIINE-ENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSN--------IVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN---KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYT--NTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYF---SFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNAS-----------CPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSFQCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWK-PSNKD--LEKSDRD-SLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 1173
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A564YLA1 (Receptor protein-tyrosine kinase OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6873 PE=4 SV=1) HSP 1 Score: 631.713 bits (1628), Expect = 0.000e+0 Identity = 444/1252 (35.46%), Postives = 617/1252 (49.28%), Query Frame = 2
Query: 266 CTHIQGSIYILGITKLES-KERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVD-----LDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQ--ILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTIT----NKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQ-LKNCKKILGYIVLTEDSF--VKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISE-TELEFLGLKSLKEINGPFRFFKNQKLCYMN-----IPVNELFKNVKNFYYIPSNCTDK--ICHKDC-SEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQ------------------------------KCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNC-----SEY---NSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKT----CHEGTYAFPNDRP--------DISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESY--GTKIIDSISY----------CKTCHSSCKGCYGSTIFN---CTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKL---EETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKN------------------------------------MGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEI 3634
CTHI G++ + I +LE+ + +L+F SI E+ G++ I ND+++I +LRIIRG +G D SL ++ NA +D LD R+L I HNVIF NP + + ++ N LF +P Q IL S T D C T CWGP A+QCQ CG S CR+ +E C+D C+GGC +S C AC+N LN C+ C P + + N EF+Y C K+CP ML T CV +C + C+ C + C N + ++F N F L + K C G I +++DSF + + +E L+ NL L+E+ G + Y + L L I + T LEFLG+KSL+ ++ LCY + +P+ +NVK+ P+ C + +CH +C E GCWGPG +C C Y+A G CV+DC+ GF+ P N+S + KC +CH EC TC GP NQCI CKN R TCV CS++ Y + K CLPC P C SE + C+G G+GGC C + + C+ T H G + D ++ + C+PC C C G C+ CK +++ C CP D++Y IID +S C CH C G G T F C C+ KI +D KF CN TCPP E+ + +CL+ + + L R + + +L L+I ++ +V+ KA RI+ LK+ Y+N+ P+ KD S+ PNMGR +++ +DL F++ +G GAFG VY+GKW++PK A G L VAIKVI++ ++ ++ EAK+MASV H +CL IGVCL+ + C++S +V+EGSLD++L +K+ + S +LSW+EQIADGM YL +R IIHRDLAARNVLV E VQITDFGL+KMLE+ + ++++TG+VPIRWLAIETL G YSH+TDVW+YGVTLWEIFTFGK PYE+ AT DI D V+KG RLSQP+IC+LD Y++MV CW+E RP F LM+ F YC+ PGRYL I+GD Y I
Sbjct: 62 CTHIIGNLVLCYIKRLENGSDPDLSFLSSIREVSGYVFISDNDVKRIPLTSLRIIRGRVPYHY----EGKGDISLYIARNAKSLDYGLEILDLRNLTVIQQHNVIFWDNPFLCHFQFTVDINSLFANPSKQRRILVSKNDTISSYGCDYEKTHCH--KECTSGHCWGPDADQCQMIAKCGQGSSK---YCRF--DKEDAFCDDACIGGCTNS-SSNCWACRNKLNGDTCISSC--PPKHQVNQVTSRQELNPEFKYDVHDICVKECPEPMLKMETVCVIECDFKTTMPVNGTCVPCTTSPCANHCVQKSIF--------GNGFPLMTSKTAKKFKECYYYSGAIYISKDSFNLKRDPLKLEDLW-NLYNLREIVG-YIYIDLSDKDIPLQNLTFLENLYKVTTEFSGGLSLQSSLTIHDATNLEFLGMKSLRYMDFSAILNGLPSLCYTSGLEKVLPIRR--QNVKD----PAQCEKEGHVCHSECLPEAGCWGPGPAMCARCCTYEADGVCVADCADAPGFFLPPNTSAIIRSGFRCPTLPLTPEQVDAMSSEEIMAAIKPALKCAKCHEECAETCTGPEANQCIGECKNFRSGDTCVRRCSQDHY---TEDKICLPCSPKCLPPLKSELIPEGVSACSGLGEFLGLGGCTFCHFVQKDKATSKYQCLNTRCPPQHFGNSTYLKHLSLEKEELSMDNTQVANIAFQECIPCHPECEICAGPGNHISVCQKCKNWMYRSECVSTCPPDDTYMPDPSIIDQLSEREKKMLEKRECLRCHEQCSG--GCTAFGPEFCNNCRYAKIMIDGNKFICNSTCPP-----ELYRMENTNLCLNSEQYEKMLGANATRARNQALIAAGIVLLFLLIFSLIFVVLCFNYKAKRSRIKEALKSTYTNVKAPDMKDAKS-SREPNMGRWEMINIDDLSFDENKTLIGKGAFGEVYRGKWRVPKRVLNQFNLARGT-SLDVAIKVIRSSASGPSQGGPATNPGVNASDSSSNASQVDANTIDRITARSNLQDMLAEAKVMASVQHKNCLPLIGVCLTRKMQCMVSMFVEEGSLDRYLRLHKDDLNSFTLLSWAEQIADGMAYLEERGIIHRDLAARNVLVQSREHVQITDFGLAKMLENGDEDSVVVRTGRVPIRWLAIETLQSGIYSHKTDVWSYGVTLWEIFTFGKQPYENIATADIKDHVMKGVRLSQPEICTLDTYMVMVRCWMEEQESRPTFLELMKCFHKYCQTPGRYLYIEGDEYAI 1271
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A0X3PH98 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1) HSP 1 Score: 613.609 bits (1581), Expect = 0.000e+0 Identity = 436/1303 (33.46%), Postives = 630/1303 (48.35%), Query Frame = 2
Query: 149 TFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLES-KERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAH-----LVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKC-----SDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPY--SGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYE-----NLNKLQELEGGFSY--FKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAIS---ETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDK--ICHKDCSE-KGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPIN---------------------------------------------SSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSE--------YNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCV-KTCHEGTYAFP-----------NDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSIS----------YCKTCHSSCKG-CYGSTIFNCTRCKNKKIYLDKK--KFYCNDTCPPLKSVEEIEKGSGDIVCLSL--WESKAKLEETK-RTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKN--EETLLKKASGDFYLPVAIKVIKNMGN-------------------------------EEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEI 3634
+ EYP IC++ NV ++ +L+ S+ CTHI G++ + + + ++ + +L+F SI E+ G++ I ND+ +I +LRIIRG + + G++ +LV+S NA L LD R L I HNV NP++ Y+ + ++ LF +PK Q DLI + C S T +CWGP +QCQ ++ C S C Y G C+D C+GGC G +S C AC++ LN + C C Y S N EF+Y C K CPA L +T CV +C + C C + C +F G N + + ++K C+ G I L +F K L NL L+E+ G + Y F + + ++ SD +L A+S + LEFLG KSL+ ++ LCY++ + ++ P+ C ++ +CH +C GCWGPG +C C + A CVS C + GFY P S ++ + C RCH EC TC + CI CK+ +E CV++CS+N+Y +K CL CHP CS + C+GP S G GGC C I + + C+ + C Y P N PD + C PC LC C+G S C C+G +K C CP D++Y +++ C CH C G CY + +C C+ +KI +D++ KF CN TCPP + +CL +E + T+ R I +G + + + ++ ++ IV KA +I LK+ Y+N P+ K + S+ PNMGRL I++ +DL F++ S PLG GAFG VY+GKW++PK E +++ L VA+KVI++ + ++ EAK+MASVSH++CL IGVCL+ C++SA+V+ GS+D++L NK+ + S +LSW+EQIADGM YL R IIHRDLAARNVL+ E VQITDFGL+KML+S + +++++G+VPIRWLAIETL G YSH+TDVW+YGVTLWEIFTFGK PYE+ T DI D V+KGGRL+QPDIC+LD Y++MV CW+E + RP F LM+ F D+C+ PGRYL IQGD + I
Sbjct: 24 SLTPEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQYSE-CTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGM--VPYYIPSLGNS--ALVISRNAFNKTVGLEVLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALR-VSNSDLISQSGCDFDNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDTSRYCLMDGYNLGTT---CDDACIGGCTGH-SSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIF-------GTNFPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVG-YIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSL----GIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPSLCYLS-GLKQILPMRTKAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYAD-ETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCHFIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVCEGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNENATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNTN----LCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQ-AASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRILAEYNWPRSTN---LDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYLYIQGDEFAI 1294
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 266.544 bits (680), Expect = 1.503e-72 Identity = 175/508 (34.45%), Postives = 251/508 (49.41%), Query Frame = 2
Query: 2159 FTCLPCPELCSKCKGK----SPKNDECEVCKGVWHKNTCRLRCPRD-----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGS-GDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
TCL C C G P D C C C RCP+ ++ K DS+ C+ CH +C +GC G + +C K P + I G G I+ + + +R ++KRK R+ E L EP + + PN L I+ + + + K LG GAFG VYKG W +P+ E D +PVAIKV++ + + + ++ EA +MASV H H R +G+CL+ L+S + G L ++ NK+ I S +L+W QIA GM YL R+++HRDLAARNVLV + V+ITDFGL+K+L S +KE GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ +I + KG RL QP IC++DVY+IMV CW+ RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 495 MTCLECDPECRPLNGSLTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYK------------------PFSGMSVIAAGVVGGILAFVILSLGVAVLVRRR------------------------HIKRKRTLRRLLQE-----RELVEPLTPS----GEAPNQSLLRILKETEF---KKIKVLGSGAFGTVYKGLW-VPEGE---------DVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQ-LVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLL-SADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSP 936 HSP 2 Score: 124.79 bits (312), Expect = 3.591e-28 Identity = 164/651 (25.19%), Postives = 261/651 (40.09%), Query Frame = 2
Query: 182 CQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPA-MMLPENTGCVHKCSEGYFK---NKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV-----LTEDSFVKHNITVEMLYENLN---KLQELEGGF--SYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMNIPVN--ELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC--LN---TCVGPNPNQCIKGCKNKRENGTCVASCSKNF----------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
CQ N ++ L + E + + + S NCT I ++ I S E +L+F SIEE+ G+++I N +I NLR I +GHT + D +L ++ +N ++ ++ LP L S T C C + CW P CQ T C + S C + CCN C GC G + C AC++ ++ C + C Y+ N + +Y+ G C K CP ++ ++ CV CS G ++ + C KC G +C C+ + G+ G + + ++ +NC I G ++ L D+F K T +M LN ++E+ G Y+ N F + + I + + LGL++L+EI +G N KLCY N P + LF++ P+ C ++ C + C+ +GCWGPG +C+ C+ Y +CV+ C+ +G + N CL C PEC LN TC P P+ C++ C + R+ CVA C + YP + + C CH NC++ CTGP
Sbjct: 20 CQGGNNRMTLLSTVDEHYQNMVKMYS-NCTVILENLEI----TYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLR------------IIRGHTLY-------------DGLALAVLSNYN----NSKGLRELP----------------LISLT-------GKMCHSDCYNGS------CWAPGRANCQTFTKLTCAEQCSGRCK-----GPKPSDCCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEG-LCPKV---CSGLGV-GNLVGV--MSINSSNIDSFENCTTINGDVLILKTTLNGDTFTK---TPKMDPAKLNVFRTVKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTKHQGTV-------SLGIGKLPITHLGLRALREISDGDVSISANAKLCY-NSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE----VNMTCLECDPECRPLNGSLTCSKPGPDGCVE-CAHFRDGPHCVARCPQGIPGEKDTLVWKYP--DSMRVCQLCHQNCTQG----CTGP 573
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 266.544 bits (680), Expect = 2.620e-72 Identity = 175/508 (34.45%), Postives = 252/508 (49.61%), Query Frame = 2
Query: 2159 FTCLPCPELCSKCKGK----SPKNDECEVCKGVWHKNTCRLRCPRD-----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGS-GDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
TCL C C G P D C C C RCP+ ++ K DS+ C+ CH +C +GC G + +C K P + I G G I+ + + +R ++KRK R+ E + L EP + + PN L I+ + + + K LG GAFG VYKG W +P+ E D +PVAIKV++ + + + ++ EA +MASV H H R +G+CL+ L+S + G L ++ NK+ I S +L+W QIA GM YL R+++HRDLAARNVLV + V+ITDFGL+K+L S +KE GKVPI+W+A+E++ Y+H++DVW+YGVT+WE+ TFG PY+ +I + KG RL QP IC++DVY+IMV CW+ RP F+ L+ F+ ++P RYL IQGD +PSP
Sbjct: 555 MTCLECDPECRPLNGSLTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYK------------------PFSGMSVIAAGVVGGILAFVILSLGVAVLVRRR------------------------HIKRKRTLRRLLQERE-----LVEPLTPS----GEAPNQSLLRILKETEF---KKIKVLGSGAFGTVYKGLW-VPEGE---------DVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQ-LVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLL-SADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSP 996 HSP 2 Score: 155.606 bits (392), Expect = 1.294e-37 Identity = 177/658 (26.90%), Postives = 278/658 (42.25%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAH----LVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFT--DPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRG--PYSGGIGGTITNKEFRYHAGFFCSKQCPA-MMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV-----LTEDSFVKHNITVEMLYENLN---KLQELEGGF--SYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEI-NGPFRFFKNQKLCYMNIPVN--ELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC--LN---TCVGPNPNQCIKGCKNKRENGTCVASCSKNF----------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
+CQ N ++ L + E + + + S NCT I ++ I S E +L+F SIEE+ G+++I N +I NLRIIRG L D +L V N + L +L SL I V F NP + + +I+W ++ + D + F T +KD + C C + CW P CQ T C + S C + CCN C GC G + C AC++ ++ C + C Y+ N + +Y+ G C K CP ++ ++ CV CS G + ++ C KC G +C C+ + G+ G + + ++ +NC I G ++ L D+F K T +M LN ++E+ G Y+ N F + + I + + LGL++L+EI +G N KLCY N P + LF++ P+ C ++ C + C+ +GCWGPG +C+ C+ Y +CV+ C+ +G + N CL C PEC LN TC P P+ C++ C + R+ CVA C + YP + + C CH NC++ CTGP
Sbjct: 34 VCQGGNNRMTLLSTVDEHYQNMVKMYS-NCTVILENLEI----TYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRG-----HTLYD----GLALAVLSNYNNSKGLRELPLISLTEILKGGVKFAHNPYLCNV-ETIQWADIMSSKDSSQFVKFESTTSKDCKM---CHSDCYNGS------CWAPGRANCQTFTKLTCAEQCSGRCK-----GPKPSDCCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEG-LCPKV---CSGLGV-GNLVGV--MSINSSNIDSFENCTTINGDVLILKTTLNGDTFTK---TPKMDPAKLNVFRTVKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTKHQGTV-------SLGIGKLPITHLGLRALREISDGDVSISANAKLCY-NSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE----VNMTCLECDPECRPLNGSLTCSKPGPDGCVE-CAHFRDGPHCVARCPQGIPGEKDTLVWKYP--DSMRVCQLCHQNCTQG----CTGP 633
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: ENSAMXT00000002946.2 (pep primary_assembly:Astyanax_mexicanus-2.0:12:28119056:28308465:-1 gene:ENSAMXG00000002862.2 transcript:ENSAMXT00000002946.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 262.692 bits (670), Expect = 5.540e-71 Identity = 187/557 (33.57%), Postives = 274/557 (49.19%), Query Frame = 2
Query: 2012 PGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKS-----PKNDECEVCKGVWHKNTCRLRCPRDESYGTKII----DSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
PG C C R +CV++C+ Y R DI F G C+ C C K K+ P D+C C + C +CP T I +S + C CH +C +GC G I +C LD+ PL + I G V + + A K K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L++ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F ++P RYL IQGD ++PSP+
Sbjct: 469 PGPDQCLSCRFYSRGR-----TCVRSCN--LY-----RGDIREF--ANGSVCMECDSQCEKAGDKTMTCHGPGPDQCTKCLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQGCTGPRIQDCIG------MLDRT---------PLIAAGVI---GGMFVAVIVALGFAIYVRRKSIK------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGTGAFGTVYKGIW-VPEGESV---------KIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVRSPNHIKITDFGLARLLDA-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFCRMARDPQRYLVIQGDDCMKLPSPN 943 HSP 2 Score: 154.836 bits (390), Expect = 2.045e-37 Identity = 167/631 (26.47%), Postives = 254/631 (40.25%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQ-ELEGGFSYFKD--NHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFA---ISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSN-----CTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPEC------LNTCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERI 2047
+NC + G++ I I + R LNF SI E+ G++++ N + + +NLRIIRG + G L+ L ++L I V D N K+L H+ I W ++ +P+A++L P+ R +C C CWG +QCQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P Y+ N + +Y G FC K+CP + +++ CV +N+ CI C ++C P + H +L L+ K L+ D F +Y + L E F K+ L ++ N+ + I Y + + + + L +SLKEI+ G N +LCY N + LF+ I SN CT + +C K CSE GCWGPG C CR Y TCV C+ +G + C+ C +C TC GP P+QC K C + ++ CV C + + C PCHPNC++ CTGP IG ++ I
Sbjct: 28 ENCEVVMGNLEITSI----ERNRNLNFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK----------------LYEGRYALLGL--KNLTEILNGGVYVDQN---KFLCHADTIHWQDILKNPRAELLVVPSNNSGSTCR-RCHRSC-------NGRCWGHQEDQCQTLTKTVCAEQCDGRCFG-PYVSD----CCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPKAKYTYGAFCVKKCPHNFVVDHSSCVR-------ENRIKMCIPCT-DICPKGKDPSSF-----HCHTLLKPFLSPLSLISKKTLNSFF-LSFLSSDLFPAQFSPNRDMYHGIGALDPERLNVFRTVKEITGFLNIQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITALQFQSLKEISAGNVYITNNSQLCYYNTVNWTGLFRTGGQRALIKSNKDPRECTQERMVCDKLCSEDGCWGPGPDQCLSCRFYSRGRTCVRSCNLYRGDIR----EFANGSVCMECDSQCEKAGDKTMTCHGPGPDQCTK-CLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQG----CTGPRIQDCIGMLDRTPLI 597
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: erbb4b (erb-b2 receptor tyrosine kinase 4b [Source:ZFIN;Acc:ZDB-GENE-030918-5]) HSP 1 Score: 262.307 bits (669), Expect = 7.149e-71 Identity = 196/592 (33.11%), Postives = 284/592 (47.97%), Query Frame = 2
Query: 1934 DSKAC----LPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTC--HEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGT-----KIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
D K C + C P CS+ C GP G C C R +CV++C H+G D+ F G CL C C K C G P D C C C +CP D GT K ++ + C CH++C +GC G + +C +D+ L V I G V +S+ K K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L+ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F ++P RYL IQGD ++PSP+
Sbjct: 441 DPKECIMEKMICDPLCSDGG---CWGP----GPDQCLSCRFFSRGR-----TCVESCNLHQG---------DVREF--ANGSVCLECDAQCQKADDDGLTCTGPGP--DHCVKCLHFKDGPNCVEKCP-DGLQGTNSFIFKYAEANNECHPCHANCTQGCTGPRLQDCIG------MIDRTPLIAAGVIGGLFVVVIIALG----VAVSVRRKSIK--------------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGAGAFGTVYKGIW-VPEGETV---------KIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDG-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYLVIQGDDRMKLPSPN 938 HSP 2 Score: 159.458 bits (402), Expect = 9.161e-39 Identity = 165/632 (26.11%), Postives = 253/632 (40.03%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDK-------ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERI 2047
+NC + G++ I I + R+L+F SI E+ G++++ N + + +NLRIIRG + ++ GN L L ++L I V D N K+L H+ I W ++ + ++ L P+ S C+ CWGP NQCQ +T+C + C Y++ CC+ +C GGC+G + C AC N + CV C P Y+ N +Y G FC K+CP + +++ CV C +NK CI C ++C D + + A D +N + + NC KI G +V F+ I + +Y N+ L + + F+ L + + + L L+S++EI+ G N +LCY N I LF+ I +N K IC CS+ GCWGPG C CR + TCV C+ +G + CL C +C TC GP P+ C+K C + ++ CV C Y N+ C PCH NC++ CTGP IG ++ I
Sbjct: 23 ENCEVVMGNLEITSI----DRSRDLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGTRLYEDRYALAIFLNYRR--DGNFGLRQLGLKNLTEILHGGVYVDQN---KFLCHADTIHWQDIVKNARSDHLVVPS---------NSSSSCQRCHRACNGRCWGPKENQCQSLTKTVCAEQCDGRCFG-PYVSD----CCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPRAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENKIKMCIPC-TDICPKACDGIGTASLQTAQTVDSSN--------IDKFINCTKINGNLV-----FLITGIKGD-VYHNIEALDPEK--LNVFRTVREITGKTRSILTFSGR-----------GISLLVLKQQWITSLQLQSMREISAGNVYITNNSQLCYYNTINWTSLFRIPTQKALIRNNRDPKECIMEKMICDPLCSDGGCWGPGPDQCLSCRFFSRGRTCVESCNLHQGDVR----EFANGSVCLECDAQCQKADDDGLTCTGPGPDHCVK-CLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANNE--CHPCHANCTQG----CTGPRLQDCIGMIDRTPLI 592 HSP 3 Score: 59.3066 bits (142), Expect = 3.543e-8 Identity = 75/295 (25.42%), Postives = 115/295 (38.98%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKI-TFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPT------VTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTC------------RYINGEEQGCCNDQCLGG------CNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGT 970
P T IC D + SL ++ + + +I + NCT I G++ L IT ++ D + IE D EK+ F+ +R I G R+++ SL+V + L +S+R I+A NV +N ++ Y ++I W LF P + L + + +I CSD CWGP +QC ++ S TC + NG C+ QC C G G C C + + CVE C G+ GT
Sbjct: 293 PCTDICPKACDGIGTASLQTA-QTVDSSNIDKFINCTKINGNLVFL-ITGIKG-------------DVYHNIEALDPEKLNVFRTVREITGKT---RSILTFSGRGISLLVLKQQWITSLQLQSMREISAGNVYITNNSQLCYY-NTINWTSLFRIPTQKALIRNNRDPKECIMEKMICDPLCSDG----------GCWGPGPDQC-----LSCRFFSRGRTCVESCNLHQGDVREFANGSVCLECDAQCQKADDDGLTCTGPGPDHCVKCLHFKDGPNCVEKC----PDGLQGT 549
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: ENSAMXT00000030092.1 (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:103038099]) HSP 1 Score: 254.603 bits (649), Expect = 4.922e-68 Identity = 176/537 (32.77%), Postives = 267/537 (49.72%), Query Frame = 2
Query: 2075 SCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKII----DSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
+CVK+C+ Y+ D+ F G C+ C C K C G P D+C C + C +CP T I +S + C CH +C +GC G I +C LD+ T L V I G +++ + ++ K++ + +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVA+K++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L+ T +KE GK+ I+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ +I + + KG RL QP IC++DVY++MV CW+ + RP F+ L+ F ++P RYL IQGD ++PSP
Sbjct: 547 TCVKSCN--LYSG-----DVREF--ANGSVCVECDGQCEKTGDRTVTCHGPGP--DQCTKCLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQGCTGPRIQDCIG------LLDRTPLIVAGTIGGLFVVVIIALG------FAIFARRKSIK------------------------------KKRCLRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGTGAFGTVYKGIW-VPEGESV---------KIPVAVKILSETTGPKASVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLD-TNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPPCEIPEILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELVAEFCRMARDPQRYLVIQGDDCMKLPSP 1004 HSP 2 Score: 158.303 bits (399), Expect = 2.194e-38 Identity = 176/655 (26.87%), Postives = 273/655 (41.68%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQT--LCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNH---CIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELE--GGFSYFKD--NHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSN-----CT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF-------YPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVS 2077
+NC + G++ I I + R LNF SI E+ G++++ N + + +NLRIIRG + +G ++ ++ G L L ++L I V D N K+L H+ I W ++ +P+A++L P+ + + C+ CWG +QCQ T +C + C Y++ CC+ +C GGC+G + C AC N + CV C P Y+ N + +Y G FC K+CP + + + CV C + + N CI C ++C D + ++A D +N + + NC KI G ++ F+ I +M + E LN + + GF + ++ N NL L+S I L ++ IS L +SL+EI+ G N +LCY N + LF+ I SN C+ +C K CSE+GCWG G C C+ Y TCV C+ Y+ + C+ C +C TC GP P+QC K C + ++ CV C + + C PCHPNC++ CTGP IG LL R IV+
Sbjct: 70 ENCEVVMGNLEITSI----ERNRNLNFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK------LYEGRYALAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQN---KFLCHADTIHWQDIVYNPRAELLVVPS--------NNSGNSCRRCHRSCNGRCWGHQEDQCQSLTKMVCAEQCDGRCFG-PYVSD----CCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPKAKYTYGAFCVKKCPHNFVVDQSSCVRACPSNKMEVEENQVKMCIPCT-DICPKVCDGIGTGSLQMAQTVDSSN--------IHKFVNCTKINGNLI-----FLITGIKGDMYHGIAALDPERLNVFRTVREITGFLNIQSWPENMTNFGVFSNLATIGGRSLYSGISLLILKLRWIIS------LQFQSLQEISAGNVYITNNSQLCYYNTVNWTGLFRTRGQRAVIKSNKDLRECSQLQMVCDKLCSEEGCWGSGPDQCLSCKFYSRGKTCVKSCN----LYSGDVREFANGSVCVECDGQCEKTGDRTVTCHGPGPDQCTK-CLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQG----CTGPRIQDCIG--------LLDRTPLIVA 661 HSP 3 Score: 56.6102 bits (135), Expect = 2.612e-7 Identity = 78/294 (26.53%), Postives = 120/294 (40.82%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDL----ILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTC------------RYINGEEQGCCNDQC------LGGCNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL + + + +I + NCT I G++ L GI L+ ER F ++ EI G L I+ N F NL I G R+L ++ SL++ ++ L F+SL+ I+A NV +N ++ Y +++ W LF + + KDL L+ C C ++ CWG +QC K+ S TC + NG C+ QC C+G G +CT C ++ + CVE C
Sbjct: 341 PCTDICPKVCDGIGTGSLQMA-QTVDSSNIHKFVNCTKINGNLIFLITGIKGDMYHGIAALDP-ERLNVFRTVREITGFLNIQSWPENMTNFGVFSNLATIGG-----RSL----YSGISLLILKLRWIISLQFQSLQEISAGNVYITNNSQLCYY-NTVNWTGLFRTRGQRAVIKSN--KDLRECSQLQMVCDKLC------SEEGCWGSGPDQC-----LSCKFYSRGKTCVKSCNLYSGDVREFANGSVCVECDGQCEKTGDRTVTCHGPGPDQCTKCLHLKDGPNCVEKC 609
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 250.751 bits (639), Expect = 3.019e-69 Identity = 138/343 (40.23%), Postives = 208/343 (60.64%), Query Frame = 2
Query: 2621 KRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
+++A+ IE EL EP + PN +L I+ + +L + K LG GAFG V+KG W P+ E D +PVAIKV++ + + + ++ EA +MASVSH H +R +G+CL+ L++ + G L ++ +K I S ++L+W+ QIA GM+YL ++ ++HRDLAARNVLV + V+ITDFGL+++L+ + E GK+PI+WLA+E++ ++H++DVW+YGVT+WE+ TFG PYE DI + + KG RL QP IC++DVY+IMV CW+ RP F+ L F+ ++P RYL IQGD +PSP
Sbjct: 538 RKRAMRRYIEKEL-------VEPLTPS----GAAPNQAQLRILKETEL---RKGKMLGSGAFGTVHKGIWT-PEGE---------DVKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQ-LVTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLD-INEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKMARDPQRYLVIQGDDRMTLPSP 854 HSP 2 Score: 125.176 bits (313), Expect = 4.135e-29 Identity = 124/468 (26.50%), Postives = 184/468 (39.32%), Query Frame = 2
Query: 731 CWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQG-----CCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEG------YFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIV-----LTEDSFVKHNITVEMLYENLNKLQELEG------------GFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKN-QKLCYMN-IPVNELFKNVKNFYYIPSNCTDKICHKD-------CSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN-----TCVGPNPNQCIKGCKNKRENGTCVASCSKNF----------YPPLNDSKACLPCHPNCS 1972
CWG CQ+ T + T R +G G CC+ QC GC+G + C ACKN + CV C P Y+ N + +Y G C K+CP + + CV C G + K K C C G + + + A ++ +NC KI G I + D ++K ++E+ G F+ F +N + + + L + IPN+ + LGL SL+E++ + KN ++LCY N I +F + + Y+ N + C+ D CSE GCWGPG C CR + A +CV C +G Y + + C C PECL TC GP N C++ C + ++ CV++C YP N++ C PCHPNCS
Sbjct: 56 CWGNGMKYCQKCT--------KLTCARQCDGRCHGPTPSECCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKFGKKKCETCTDVCPKACDG----------IGTGNLSRSQTVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMIQAWPENMTDFAVF-ENLTTIRGRVLQSVGRTFSLLVARIPNITA-------------LGLASLQEVSAGNVYLKNNERLCYYNTIKWPAVFVSEQQTSYVHDNKPEADCNADGAVCDLLCSEHGCWGPGPDQCISCRFFRRARSCVESCYITEGPYR----EHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVR-CAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNT--CQPCHPNCS 484 HSP 3 Score: 63.5438 bits (153), Expect = 3.341e-10 Identity = 68/251 (27.09%), Postives = 110/251 (43.82%), Query Frame = 2
Query: 260 KNCTHIQGSIYILG----------ITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQC-------QQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLG-----GCNGGGASKCTACKNMLNEKKCVELC 937
+NCT I G+I L I L+ + + F SI+EI GHL+I+ N + F+NL IRG R L G T FSL+V+ ++ L SL+ ++A NV +N ++ Y ++IKW +F + + V + D +D ++ CWGP +QC + ++ S Y +E ++ C+ +CL C G G++ C C + + CV C
Sbjct: 216 ENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNV-FRSIKEITGHLMIQAWPENMTDFAVFENLTTIRG-----RVLQSVGRT-FSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYY-NTIKWPAVFVSEQQ----TSYVHDNKPEADCNADGAVCDLLCSEHGCWGPGPDQCISCRFFRRARSCVESCYITEGPYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSAC 454 HSP 4 Score: 50.8322 bits (120), Expect = 2.783e-6 Identity = 42/137 (30.66%), Postives = 57/137 (41.61%), Query Frame = 2
Query: 1514 INGPFRFFKNQKLCYMNIPVNELFKNVKNFYYI------PSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASC 1906
++G +N+ LCY N + + VK + + CT CHK C K CWG G K C +C K A C C + P S CH +C C GP C CKN ++G+CV+ C
Sbjct: 5 LHGGVYIKENKHLCYHN--TVDWWDIVKEGSIVNIDMDNSTTCTS--CHKGC-HKHCWGNGMKYCQKCTKLTCARQCDGRC------HGPTPSEC--------CHSQCAAGCDGPRDTHCF-ACKNFNDSGSCVSHC 121
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 203.756 bits (517), Expect = 1.406e-53 Identity = 151/520 (29.04%), Postives = 246/520 (47.31%), Query Frame = 2
Query: 2174 CPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCK------GCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCP---PLKSVEEIEK-GSGDIVC------------------LSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEI-ESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGD-PYEIPSP 3643
C LCS P +C CK TC C + + + S + C CH+ C C+G NCTRC+N + + +C CP P +S E I K D VC W + K+ ++ V +L+L + + L+++ + + +E E LT ++ PN +L I+ + +L + K LG GAFG VYKG W +P+ E + VA+KV+++ + + + ++ EA +MASV H H +R +G+C+S L++ + G L +++ ++ ++ S ++L+W QIA + ++ DL LV L + + +S D + +PI+W+A+E++ K++H++DVW+YGVT+WE+ TFG PY+ + DI + KG RL QP +C++DVY+IMV CW+ RP F L F+ ++P RYL IQGD P +PSP
Sbjct: 476 CDALCSAEGCWGPGPMQCLSCKFHKRGKTCVESCSVLDGDEREFV-SGALCIACHAECMLINGSLTCHGPGPDNCTRCRNYR-----EGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGEIGERHKGAPYWANVNKVPVIAAGVVSGLFAVFLLLLALFIYKRHQNALRKRTLRKYVENERPQLVQPLTPSGAQ--------PNQAQLRILKETEL---KKGKVLGSGAFGTVYKGIW-VPEGESV---------KIAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQ-LVTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVR---LVMSLRTPPRITLASANLFQSIDDAKHW-HDRDMPIKWMALESIQYRKFTHQSDVWSYGVTVWELMTFGGKPYDGISARDIPGLLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPRFSELATDFSKMARDPSRYLVIQGDEPMALPSP 963 HSP 2 Score: 75.485 bits (184), Expect = 8.581e-14 Identity = 43/127 (33.86%), Postives = 58/127 (45.67%), Query Frame = 2
Query: 1634 ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECL-----NTCVGPNPNQCIKGCKNKRENGTCVASCSKN--------FYPPLNDSKACLPCHPNCSE 1975
+C CS +GCWGPG C C+ + TCV CS G +S C+ CH EC+ TC GP P+ C + C+N RE CV C + Y ++ C PCH NC++
Sbjct: 475 VCDALCSAEGCWGPGPMQCLSCKFHKRGKTCVESCSVLDG----DEREFVSGALCIACHAECMLINGSLTCHGPGPDNCTR-CRNYREGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQ 596 HSP 3 Score: 51.2174 bits (121), Expect = 2.255e-6 Identity = 48/217 (22.12%), Postives = 87/217 (40.09%), Query Frame = 2
Query: 263 NCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVD--LDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDL----ILRDKCSDQCKLWANFTQVFCWGPSANQCQ--QQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKC 889
NC + G+ L IT + + +I E+ G+++I N+++ + +NLR++RG L D+ + +++++ N + + L + LR + I ++ P W+++ + F P V D + C CK FCWG CQ T+C + C + CC+ C GC G + C
Sbjct: 27 NCEVVMGN---LEITYIRNGSDLSFLRTIREVSGYVLIALNEVDHVPLENLRVVRGT-----RLYDQRYA-LTVLLNYNDSVPEERLGLKELR-LTRLTEILRGGVYVRKEPGLPSWDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSCK-------NFCWGSGPQYCQTFTSTICAKQCDGRC-----YGLDPNQCCHKHCASGCTGPRETDC 221
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005822.1 (pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 gene:ENSPMAG00000005273.1 transcript:ENSPMAT00000005822.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 178.333 bits (451), Expect = 3.431e-51 Identity = 84/170 (49.41%), Postives = 117/170 (68.82%), Query Frame = 2
Query: 3137 GMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
GM YL R ++HRDLAARNVLV V+ITDFGL+K+L+ + E + GK+PI+WLA+E++ ++H++DVW+YGVTLWE+ TFG PY+ DI + + KG RL+QP IC++DVY+IMV CW+ RP F+ L F+ ++P RYL IQGD ++PSP
Sbjct: 1 GMNYLEDRRLVHRDLAARNVLVKAPNHVKITDFGLAKLLD-LNETEYHSEGGKLPIKWLALESIQQRIFTHQSDVWSYGVTLWELMTFGGKPYDGVPARDIPELLEKGERLTQPPICTIDVYMIMVKCWMIDAESRPKFRELAAEFSKMARDPTRYLVIQGDERMKLPSP 169
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: EPHB2 (EPH receptor B2 [Source:HGNC Symbol;Acc:HGNC:3393]) HSP 1 Score: 174.866 bits (442), Expect = 1.522e-44 Identity = 104/342 (30.41%), Postives = 167/342 (48.83%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNE-EIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLES--TKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESL 3805
+G G FG V +G+ ++P E + VAIK +K+ E + + EA +M H + +R GV +++ +++ GSLD FL +N + T + ++ IA GM YL+ N +HRDLAARN+LV+ +++DFGLS+ LE+ T GK+PIRW A E + K++ +DVW+YG+ +WE+ ++G+ PY D D+ + V + RL P C ++ +M++CW +S N RP F ++ T +NP ++ +T+ LPLL DR + DFT +DE L
Sbjct: 586 IGSGEFGEVCRGRLRMPGKRE-----------MYVAIKTLKSAYTEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENDPTDPTYTSGMGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNEDVINAVEQDYRLPAPMDCPAALHQLMLDCWQKSRNDRPKFGQIVSTLDKMIRNPASLKAMS-----------------------------CVTSAPSLPLL------DRTMPDFTSFASVDEWL 881
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 164.466 bits (415), Expect = 1.964e-44 Identity = 96/292 (32.88%), Postives = 155/292 (53.08%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWK-IPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFL-IRNKNKI-------------TSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQG 3619
LG GAFG VY + + +E +L VA K +K++ + + +EA+++ ++ H H +RF GVC+ E ++ Y+K G L+KFL +R + + + ML+ QIA GM YL ++ +HRDLA RN LV V+I DFG+S+ + ST + T +PIRW+ E++ K++ ++DVW+ GV LWEIFT+GK P+ + ++ D + +G L +P C ++VY +M+ CW P R ++++ K YL I G
Sbjct: 82 LGEGAFGKVYLAECSSLDVGQEPML----------VAAKTLKDLSDGARKDFYREAELLTNLQHEHIVRFYGVCVEGEPLIMVFEYMKNGDLNKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVYSTDYYRVGGHT-MLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRVLERPRSCPMEVYELMLGCWHREPQHRLGIKDILARLESLAKMSPVYLDILG 362
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 88.5817 bits (218), Expect = 5.489e-18 Identity = 71/282 (25.18%), Postives = 131/282 (46.45%), Query Frame = 2
Query: 2837 PKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSH-ETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQ---TFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFN 3670
PKNE+ +L++ K+ K + ++ ++EA + + H H R +C ++ YV G L ++I++ I ++ IA ++YL NI+HRDL N+++S ++I DFGLS + +S K + + + A E L Y+ E DVW++GV L+ + GKVP++D+ + + +K G++ P S++V ++ + P R + +++ + P YL P +P +IEM + N
Sbjct: 168 PKNEQDVLERQK---------KLEKEISRDK--RTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQH-GSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGS----LYFAAPELLKANPYTGPEVDVWSFGVVLF-VLVCGKVPFDDENS-SVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYL-----PKRVPL--TIEMLDIN 424
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 86.2705 bits (212), Expect = 2.205e-17 Identity = 53/197 (26.90%), Postives = 98/197 (49.75%), Query Frame = 2
Query: 2900 KVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICS 3490
K +N+ + ++++ E ++ + H + + + G + YV GS+ L N ++ +++ QI G+ YL K+NIIHRD+ N+L+ CV+ITDFG+SK L K+ + + + W++ E + + + D+W+ G + E+FT GK P+ D + + K G + P+I S
Sbjct: 488 KTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSML-NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-GKHPFPDFSQ---MQAIFKIGTNTTPEIPS 679
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 83.5741 bits (205), Expect = 1.540e-16 Identity = 66/261 (25.29%), Postives = 127/261 (48.66%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIG-VCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQ 3568
+G G++G VYK I K+ + + VAIK + +EE+ +M E ++ +++H + +++ G + SYE L+ Y GSL + + R+ ++ ++ Q G+ YL +IHRD+ A N+L+S V++ DFG+S ++ S+ T + W+A E L + S +D+W+ G T+ E+ T PY + +I+ + ++ P S + + C++++ RP L++
Sbjct: 31 IGRGSYGVVYKA---INKHTDQV-----------VAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLE-YCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSA------LTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDANIY-YAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLK 268
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086]) HSP 1 Score: 83.1889 bits (204), Expect = 2.196e-16 Identity = 53/211 (25.12%), Postives = 102/211 (48.34%), Query Frame = 2
Query: 2939 VMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSH-ETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQ 3568
++EA + + H H R +C ++ YV G L ++I++ + ++ IA + YL NI+HRDL N+++S ++I DFGLS + + K + + + A E L Y+ E D+W++G+ L+ + GKVP++D+ + I +K G++ P S++V ++ + P R +N+++
Sbjct: 170 TVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQH-GSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGS----LYFAAPELLKAQPYTGPEVDIWSFGIVLY-VLVCGKVPFDDENS-SILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVE 373
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 80.8777 bits (198), Expect = 1.143e-15 Identity = 65/228 (28.51%), Postives = 107/228 (46.93%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIK-NMGNEEIESVMQEAKMMASVSHM-HCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNK--NKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGK-YSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLK 3457
+G G FG VYKG +G Y AIKV+ + ++E+E V +E + +AS+ + + R+ G L +I + GSL L K K +IM ++ + + K N+IHRD+ A NVL++ V++ DFG++ + T + +T W+A E + +G Y + D+W+ G+T +EI T G PY D ++K
Sbjct: 29 IGRGKFGVVYKG-----------YNVKTGRVY---AIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIM----RELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRR---QTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPPYCDVEALRAMQLIIK 234
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO47094 (Predicted protein; Vascular endothelial growth factor receptor-like protein [Source:UniProtKB/TrEMBL;Acc:A7RN88]) HSP 1 Score: 166.392 bits (420), Expect = 1.607e-45 Identity = 102/284 (35.92%), Postives = 159/284 (55.99%), Query Frame = 2
Query: 2789 LGFGAFGYVYKGKWK--IPKNEETLLKKASGDFYLPVAIKVIKNMGNE-EIESVMQEAKMMASV-SHMHCLRFIGVCLSYEKPCL--ISAYVKEGSLDKFLIRNKN---------------KITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKT-GKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTF 3574
LG GAFG VY G+ + I + + + VAIK +K E E + ++ E K++ V SH + + +G C + L I + G L +L + ++ + T + ++S + Q+A GM +L R IHRDLAARNVL++ +++ DFGL++ + K++E + T G VPI+W+AIE+LTD YS ++DVW+YGV LWEIFT G PY D D+F+++L G R+ +P C+ ++Y IM +CW+ SP RP F L++
Sbjct: 22 LGSGAFGQVYLGETEGGIDYRRPSAISMRGN---IKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLAR--DVYKNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTELVKKL 300
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 169.088 bits (427), Expect = 1.867e-45 Identity = 101/296 (34.12%), Postives = 162/296 (54.73%), Query Frame = 2
Query: 2729 MGRLMIVSKEDLIFEDESK---PLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIK-NMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLEST---KDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNP 3595
M LM V+KE I +D+ K +G G F VY+G + NE+ +K VA+K++K ++ E EA +M H + + GV +I+ +++ GSLD FL N ++T+L ++ +A GM YL++ N IHRDLAARN+LVS +++DFGLS+ L+ + + E + GK+P+RW A E + K+S +DVW+YG+ LWEI +FG+ PY + D V G RL P C ++ +M++CW + RP F ++++ F + ++P
Sbjct: 12 MEALMSVAKE--INKDDLKLEIIIGGGEFADVYRG---VLTNEDKTQEK--------VAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFDEVIRSP 294
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 169.474 bits (428), Expect = 2.021e-45 Identity = 106/333 (31.83%), Postives = 165/333 (49.55%), Query Frame = 2
Query: 2783 KPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIES-VMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLS----IQGDP----YEIPSPH----SIEMTNFNNHYGEDQFNFPSMTAETMLPLLNG 3742
K +G G FG VYKG K P G+ +PVAIK +K + + EA +M + + GV +++ ++ GSLD FL + +K++ + ++ + IA GM YL++ N +HRDLAARN+LV+ ++ DFGLS+ LE D GK+P+RW A E + K+S +DVW+YG+ LWE F+F + PY D + ++ D V G RL P C ++ IM+ CW RP F +++ ++P + IQ P EI + SI+M + H+ + + AE+ P L+G
Sbjct: 62 KVIGGGEFGDVYKGTLKRP-----------GENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLKKMDSKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELE---DSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPPMSCPKVIHQIMLECWDADRTKRPSFALIVKQLDSLIRSPEKLKDNQSVIQSKPNIDYSEITTVEEWLGSIKMGQYTEHFKQAGYRDLQTIAESEEPDLDG 380
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO35594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SL46]) HSP 1 Score: 164.081 bits (414), Expect = 2.285e-45 Identity = 93/252 (36.90%), Postives = 141/252 (55.95%), Query Frame = 2
Query: 2903 VIKNMGNEEIESVMQEAKMMASV-SHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNK------------ITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKML--ESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSI 3613
++ G E+ E ++E +M + SH + + F+ E L+ ++ +G L +L RN++K IT +LS+S QIA GM YL+K+ +HRDLAARNVLV+ + V++ DFGL++ L ES K+PI+W++ E + D ++ E+DVW+YGV LWEI T G PY +T D+F + G R+ +PDICS +VY IM +CW + P RP F +L F + YL +
Sbjct: 2 LVDTAGPEQGEEFLKEISLMKKLGSHKNIVNFLCCSTVKEPFMLVVEFLPKGDLLDYLRRNRSKQNDETGEQEDEMITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLTRDLYEESAYQGH---SNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTISTRDVFVMLRSGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTFSDLRMKFEYMLEADNPYLDL 250
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8]) HSP 1 Score: 163.31 bits (412), Expect = 4.513e-44 Identity = 95/279 (34.05%), Postives = 154/279 (55.20%), Query Frame = 2
Query: 2789 LGFGAFGYVYK----GKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGN-EEIESVMQEAKMMASVS-HMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFL--IRNK-------------NKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNL 3562
+G GAFG V K G P+N+ET+ VA+K + M E+ + + E +MM + H++ + +G + CLI+ Y G L +L IR+K ++T +LS++ QIA GM YL+++ +HRDLAARN+L+ V+I+DFGL++ + + + + TGK+P++W+A E + ++ ++DVWA+GV LWEI T G PY Q+ + + + G R+ +PD+CS ++Y +M +CW SP RP F L
Sbjct: 24 VGSGAFGKVTKATIVGLPGGPENKETV-----------VAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKL 291
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111]) HSP 1 Score: 260.766 bits (665), Expect = 3.158e-70 Identity = 191/595 (32.10%), Postives = 294/595 (49.41%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTC--HEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
+N PL ++ + C P CS+ + +GP C C+ R SC+K+C ++G +I + G C+ C C + C G P + C C C +CP S+ K ++ + C CH +C +GC G + +C ++D+ PL + I G +V ++L + + + + K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W IP+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++L+ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ +T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L FT ++P RYL IQGD ++PSP+
Sbjct: 445 RNNRNPLECARGHMVCDPLCSD-DGCWGSGPDQ------CLSCKFFSRGR-----SCIKSCNLYQG---------EIREY--ANGSVCVECDSQCEQGDDNTLTCHGSGP--EHCVKCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG------WMDRT---------PLIAAGVI-GGLFMVVIMALSVAVSVRRKNIK--------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-IPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLD-VNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYLVIQGDDRMKLPSPN 946 HSP 2 Score: 136.732 bits (343), Expect = 7.840e-32 Identity = 158/635 (24.88%), Postives = 249/635 (39.21%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAM-MLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGA--NDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKG-FYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASC-------SKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERI 2047
+NC + G++ I I + R L F SI E+ G++++ N + + +NLRIIRG + +SL + GN L L +L I V D N K+L H+ I W ++ +P + PT + + KC C CWGP NQCQ +T+C + C+ Y++ CC+ +C GGC G + C AC N + CV C P Y+ N RY G FC K+CP + T + + +K +C K GN+ +F I G N L + L ++ ++I GY+ + N+T +++ NL + GG + + + + + L+SLKEI+ G +N++LCY N + LF++ + P C +C CS+ GCWG G C C+ + +C+ C+ +G N S+ C+ C +C TC G P C+K C + ++ CV C S + + C PCHPNC++ C GP IG ++ I
Sbjct: 50 ENCEVVMGNLEITSI----DRSRNLTFLRSIREVTGYVLVALNQFDHLPLENLRIIRGTKLYEDR--------YSLAIFLNYRRDGNFGLRHLGLINLAEILYGGVYVDQN---KFLCHADTIHWQDIVKNPGFHPVVVPTNSS--VTCPKCHRSC-------NGRCWGPKDNQCQSLTKTVCAEQCDGRCSG-PYVSD----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPPCDGIGTGTLQAAQTVDSSNIDKFVNCTKINGNL---------VFLITGIKGDVYHNIEALDPEKLNVFRSVREITGYLNIQS---WPDNMTDLIVFSNLATI----GGRALYS-----------------------------GISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSPNQKVLVRNNRNPLECARGHMVCDPLCSDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIREYANGSV-----CVECDSQCEQGDDNTLTCHGSGPEHCVK-CLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQG----CIGPRLQDCIGWMDRTPLI 600
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111]) HSP 1 Score: 260.381 bits (664), Expect = 4.670e-70 Identity = 191/594 (32.15%), Postives = 293/594 (49.33%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTC--HEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSP 3643
+N PL ++ + C P CS+ + +GP C C+ R SC+K+C ++G +I + G C+ C C + C G P + C C C +CP S+ K ++ + C CH +C +GC G + +C ++D+ PL + I G +V ++L + + + + K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W IP+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++L+ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ +T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L FT ++P RYL IQGD ++PSP
Sbjct: 483 RNNRNPLECARGHMVCDPLCSD-DGCWGSGPDQ------CLSCKFFSRGR-----SCIKSCNLYQG---------EIREY--ANGSVCVECDSQCEQGDDNTLTCHGSGP--EHCVKCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG------WMDRT---------PLIAAGVI-GGLFMVVIMALSVAVSVRRKNIK--------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-IPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLD-VNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYLVIQGDDRMKLPSP 983 HSP 2 Score: 152.91 bits (385), Expect = 1.054e-36 Identity = 171/644 (26.55%), Postives = 262/644 (40.68%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNH---CIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF---VKHNITVEMLYENLNKLQELEGGFSYFK----DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKG-FYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASC-------SKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERI 2047
+NC + G++ I I + R L F SI E+ G++++ N + + +NLRIIRG + +SL + GN L L +L I V D N K+L H+ I W ++ +P + PT + + KC C CWGP NQCQ +T+C + C+ Y++ CC+ +C GGC G + C AC N + CV C P Y+ N RY G FC K+CP + ++ CV C + + NH CI C ++C D + + A D +N + + NC KI G +V V HNI + E LN + + Y +++ +L NL L+S I L + + + L+SLKEI+ G +N++LCY N + LF++ + P C +C CS+ GCWG G C C+ + +C+ C+ +G N S+ C+ C +C TC G P C+K C + ++ CV C S + + C PCHPNC++ C GP IG ++ I
Sbjct: 50 ENCEVVMGNLEITSI----DRSRNLTFLRSIREVTGYVLVALNQFDHLPLENLRIIRGTKLYEDR--------YSLAIFLNYRRDGNFGLRHLGLINLAEILYGGVYVDQN---KFLCHADTIHWQDIVKNPGFHPVVVPTNSS--VTCPKCHRSC-------NGRCWGPKDNQCQSLTKTVCAEQCDGRCSG-PYVSD----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPHNFVVDHNSCVRACPTNKMEVEDNHIKMCIPCT-DICPKACDGIGTGTLQAAQTVDSSN--------IDKFVNCTKINGNLVFLITGIKGDVYHNIEA-LDPEKLNVFRSVREITGYLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLL------VLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSPNQKVLVRNNRNPLECARGHMVCDPLCSDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIREYANGSV-----CVECDSQCEQGDDNTLTCHGSGPEHCVK-CLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQG----CIGPRLQDCIGWMDRTPLI 638
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111]) HSP 1 Score: 260.381 bits (664), Expect = 5.930e-70 Identity = 191/595 (32.10%), Postives = 294/595 (49.41%), Query Frame = 2
Query: 1910 KNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTC--HEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
+N PL ++ + C P CS+ + +GP C C+ R SC+K+C ++G +I + G C+ C C + C G P + C C C +CP S+ K ++ + C CH +C +GC G + +C ++D+ PL + I G +V ++L + + + + K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W IP+ E +PVAIK++ + G + M EA +MAS+ H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV V+ITDFGL+++L+ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ +T DI D + KG RL QP IC++DVY++MV CW+ + RP F+ L FT ++P RYL IQGD ++PSP+
Sbjct: 483 RNNRNPLECARGHMVCDPLCSD-DGCWGSGPDQ------CLSCKFFSRGR-----SCIKSCNLYQG---------EIREY--ANGSVCVECDSQCEQGDDNTLTCHGSGP--EHCVKCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG------WMDRT---------PLIAAGVI-GGLFMVVIMALSVAVSVRRKNIK--------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-IPEGETV---------KIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLD-VNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYLVIQGDDRMKLPSPN 984 HSP 2 Score: 152.91 bits (385), Expect = 1.092e-36 Identity = 168/629 (26.71%), Postives = 257/629 (40.86%), Query Frame = 2
Query: 260 KNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVV------SGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNH---CIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSF---VKHNITVEMLYENLNKLQELEGGFSYFK----DNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCT--DKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKG-FYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASC-------SKNFYPPLNDSKACLPCHPNCSEYNSTICTGP 2002
+NC + G++ I I + R L F SI E+ G++++ N + + +NLRIIRG + +SL + GN L L +L I V D N K+L H+ I W ++ +P + PT + + KC C CWGP NQCQ +T+C + C+ Y++ CC+ +C GGC G + C AC N + CV C P Y+ N RY G FC K+CP + ++ CV C + + NH CI C ++C D + + A D +N + + NC KI G +V V HNI + E LN + + Y +++ +L NL L+S I L + + + L+SLKEI+ G +N++LCY N + LF++ + P C +C CS+ GCWG G C C+ + +C+ C+ +G N S+ C+ C +C TC G P C+K C + ++ CV C S + + C PCHPNC++ C GP
Sbjct: 50 ENCEVVMGNLEITSI----DRSRNLTFLRSIREVTGYVLVALNQFDHLPLENLRIIRGTKLYEDR--------YSLAIFLNYRRDGNFGLRHLGLINLAEILYGGVYVDQN---KFLCHADTIHWQDIVKNPGFHPVVVPTNSS--VTCPKCHRSC-------NGRCWGPKDNQCQSLTKTVCAEQCDGRCSG-PYVSD----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPHNFVVDHNSCVRACPTNKMEVEDNHIKMCIPCT-DICPKACDGIGTGTLQAAQTVDSSN--------IDKFVNCTKINGNLVFLITGIKGDVYHNIEA-LDPEKLNVFRSVREITGYLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLL------VLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSPNQKVLVRNNRNPLECARGHMVCDPLCSDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIREYANGSV-----CVECDSQCEQGDDNTLTCHGSGPEHCVK-CLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQG----CIGP 623
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 258.84 bits (660), Expect = 1.474e-69 Identity = 174/511 (34.05%), Postives = 260/511 (50.88%), Query Frame = 2
Query: 2156 GFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
G CL C C K C G+ P D+C C C +CP S+ K + + C CH +C +GC G I +C ++ PL + I G IV ++L + ++ + K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MASV H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L++ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F ++P RYL IQGD ++PSP+
Sbjct: 492 GSVCLECDSQCEKMDGNSLTCLGQGP--DQCVKCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMMDRT---------------PLIAAGII-GGLFIIVIVALTVAIYARRKSIK--------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDA-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYLVIQGDDRMKLPSPN 932 HSP 2 Score: 161.77 bits (408), Expect = 1.910e-39 Identity = 159/616 (25.81%), Postives = 252/616 (40.91%), Query Frame = 2
Query: 296 LGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
L IT ++ + R L+F SI E+ G++++ N E + +NLRIIRG + +G ++ ++ GN L L RSL I V D N K+L H+ I W ++ +P+A++L P+ + ++ C+ CWG +QCQ +T+C + C Y++ CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC ++CP + +++ CV C +N+ CI C ++C D + + A D +N + + NC KI G ++ F+ I +M + E LN + ++ + ++ + + + + + +SL EI+ G F N +LC+ N I LF+ I P C + IC + CSE GCWGPG C CR + TCV C+ +N + CL C +C TC+G P+QC+K C N ++ CV C Y N+ C PCH NC++ C GP
Sbjct: 4 LEITSID-RNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGTT------LYEGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQN---KFLCHADTIHWQDVIKNPQAELLVVPS--------NNSNNGCRRCHRSCNGRCWGHQEDQCQTLTKTVCAEQCDGRCFG-PYVSD----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCT-DICPKVCDGIGTGSLQTAQTVDASN--------IDKFVNCTKINGNLI-----FLITGIKGDMYHGIGPLDPERLNVFRTVKEITGFLNIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMCSEDGCWGPGPDQCLSCRYFKRGRTCVESCN----LFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVK-CLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNE--CHPCHVNCTQG----CIGP 571 HSP 3 Score: 60.8474 bits (146), Expect = 1.206e-8 Identity = 78/289 (26.99%), Postives = 119/289 (41.18%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK--CSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECT-TCRYINGEEQGC--------CNDQC--LGG----CNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL ++ + + +I + NCT I G++ L GI L+ ER F +++EI G L I+ N + F NL I G R+L + SL++ + F+SL I+A NV +N ++ + ++I W LF P ++L L+ + C C ++ CWGP +QC K C +C NGE + C+ QC + G C G G +C C N + CVE C
Sbjct: 266 PCTDICPKVCDGIGTGSLQTA-QTVDASNIDKFVNCTKINGNLIFLITGIKGDMYHGIGPLDP-ERLNVFRTVKEITGFLNIQSWPENMTDLSVFSNLVTIGG-----RSLYSG--SGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFY-NTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMC------SEDGCWGPGPDQCLSCRY--FKRGRTCVESCNLFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKC 536
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 258.455 bits (659), Expect = 2.878e-69 Identity = 174/511 (34.05%), Postives = 260/511 (50.88%), Query Frame = 2
Query: 2156 GFTCLPCPELCSK-------CKGKSPKNDECEVCKGVWHKNTCRLRCPRD----ESYGTKIIDSISYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVI-KNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDP-YEIPSPH 3646
G CL C C K C G+ P D+C C C +CP S+ K + + C CH +C +GC G I +C ++ PL + I G IV ++L + ++ + K++A+ +ETEL EP + PN +L I+ + +L K LG GAFG VYKG W +P+ E +PVAIK++ + G + M EA +MASV H H +R +GVCLS L++ + G L ++ +K+ I S ++L+W QIA GM+YL +R ++HRDLAARNVLV ++ITDFGL+++L++ +KE GK+PI+W+A+E + K++H++DVW+YGVT+WE+ TFG PY+ T +I D + KG RL QP IC++DVY++MV CW+ + RP F+ L F ++P RYL IQGD ++PSP+
Sbjct: 641 GSVCLECDSQCEKMDGNSLTCLGQGP--DQCVKCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMMDRT---------------PLIAAGII-GGLFIIVIVALTVAIYARRKSIK--------------------------KKRALRRFLETEL-------VEPLTPS----GTAPNQAQLRILKETEL---KRVKILGSGAFGTVYKGIW-VPEGETV---------KIPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDA-DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYLVIQGDDRMKLPSPN 1081 HSP 2 Score: 166.777 bits (421), Expect = 6.911e-41 Identity = 166/655 (25.34%), Postives = 268/655 (40.92%), Query Frame = 2
Query: 179 ICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVS----GNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHS--IKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQ--QTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGP--YSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYF---KNKSNHCIKCYGNMCTN--DHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLY-------ENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEIN-GPFRFFKNQKLCYMN-IPVNELFKNVKNFYYI-----PSNCTDK--ICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLN------TCVGPNPNQCIKGCKNKRENGTCVASCSKNF---------YPPLNDSKACLPCHPNCSEYNSTICTGP 2002
+C + ++ +L ++ + L + +NC + G++ I I + R L+F SI E+ G++++ N E + +NLRIIRG + +G ++ ++ GN L L RSL I V D N K+L H+ I W ++ +P+A++L P+ + R +C C CWG +QCQ +T+C + C Y++ CC+ +C GGC G + C AC N + CV C P Y+ N +Y G FC ++CP + +++ CV C +N+ CI C ++C D + + A D +N + + NC KI G ++ F+ I +M + E LN + ++ + ++ + + + + + +SL EI+ G F N +LC+ N I LF+ I P C + IC + CSE GCWGPG C CR + TCV C+ +N + CL C +C TC+G P+QC+K C N ++ CV C Y N+ C PCH NC++ C GP
Sbjct: 118 VCPGTDNKLSTLSDLDQQYRTLRKLY-ENCEVVMGNLEITSI----DRNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGTT------LYEGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQN---KFLCHADTIHWQDVIKNPQAELLVVPSNNSNNGCR-RCHRSC-------NGRCWGHQEDQCQTLTKTVCAEQCDGRCFG-PYVSD----CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCT-DICPKVCDGIGTGSLQTAQTVDASN--------IDKFVNCTKINGNLI-----FLITGIKGDMYHGIGPLDPERLNVFRTVKEITGFLNIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMCSEDGCWGPGPDQCLSCRYFKRGRTCVESCN----LFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVK-CLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNE--CHPCHVNCTQG----CIGP 720 HSP 3 Score: 61.2326 bits (147), Expect = 1.007e-8 Identity = 78/289 (26.99%), Postives = 119/289 (41.18%), Query Frame = 2
Query: 167 PGTIICQN--DNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYIL----------GITKLESKERELNFDSIEEIDGHLIIEG---NDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK--CSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECT-TCRYINGEEQGC--------CNDQC--LGG----CNGGGASKCTACKNMLNEKKCVELC 937
P T IC D + SL ++ + + +I + NCT I G++ L GI L+ ER F +++EI G L I+ N + F NL I G R+L + SL++ + F+SL I+A NV +N ++ + ++I W LF P ++L L+ + C C ++ CWGP +QC K C +C NGE + C+ QC + G C G G +C C N + CVE C
Sbjct: 415 PCTDICPKVCDGIGTGSLQTA-QTVDASNIDKFVNCTKINGNLIFLITGIKGDMYHGIGPLDP-ERLNVFRTVKEITGFLNIQSWPENMTDLSVFSNLVTIGG-----RSLYSG--SGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFY-NTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMC------SEDGCWGPGPDQCLSCRYF--KRGRTCVESCNLFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKC 685
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000005947.1 (SMESG000005947.1) HSP 1 Score: 2849.31 bits (7385), Expect = 0.000e+0 Identity = 1474/1479 (99.66%), Postives = 1478/1479 (99.93%), Query Frame = 2
Query: 86 MTHKTYXXXXXXXXXXXXNNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSXXXXXXXXXXXXXXXXXXXXXVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNNVXXXXXXXXXXXXDDYLEPNAPGPKNTSLVDTGDPEGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR 4522
MTHKTYLILFLFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLN+KKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCP+DESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWA+GVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSQNPQNLNTRNNNTNNNNTPRLVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNN+SASQSPQISQISDDYLEPNAPGPKNTSLVDTGD EGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR
Sbjct: 1 MTHKTYLILFLFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNKKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFKDNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPKDESYGTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAFGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIPSPHSIEMTNFNNHYGEDQFNFPSMTAETMLPLLNGRDSIDRDVKDFTDNNEIDESLLSSTDKEPLPTRSMNRTSNIFKLFQDNKQSQNPQNLNTRNNNTNNNNTPRLVSLASQEEPTFRNQPLITDDDPRYVADPTEKSIKMRQQLPLQSQFLQETPRFHSNISRENHTPFNNISASQSPQISQISDDYLEPNAPGPKNTSLVDTGDSEGYLEPINPSNKSSLLNQDDYVVPSLTNTPRESMLNSKPPRNSNAFKQSKQYISMDDGNPHFSNSIDDDDGYLEPEPKSRLLNSSNR 1479
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000016935.1 (SMESG000016935.1) HSP 1 Score: 711.064 bits (1834), Expect = 0.000e+0 Identity = 442/1192 (37.08%), Postives = 641/1192 (53.78%), Query Frame = 2
Query: 140 NNATFEEEYPGTIICQNDNVQIESLHSSVEKLKIL--SIIRSKNCTHIQGSIYILGITKLES-KERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQV---FCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMC---TNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSY--FKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDKICHKDCS---EKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKA---CLPCHPNCSEYNSTI-----CTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYP--VTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCK-GCY-GSTIFNCTRCKNKKIYLD--KKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEET---KRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKD--EDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 3607
N + F +YP IC S + E K L ++ + CTHI G++ I +++ ++ + +L+F +SI EI G L I ND+++I NL++IRG RN D + + +G L ++D R+LR+I + NVI NP ++YL ++ W+++ DP Q L + KC +C+ W V FC+GPS N+CQ+QT C + + C++ E C + +C GGC+G + CT C ++ + CV C P I G + + RY G C+ QCPA +L +N CV++C + N CI+C C T + CNL I N Y L Q L+QL NC ILG + + + SF K+ +TV MLY +L ++E+ G FS F+ + H+ + + K+ +EFLGLK LK++ G CY++ IP E+ P N C+K C CWGPGN++CY C Y A +CV CS G++ + + KC CHP C C GP P C C+ E TCV +CS +F+P N+ A C CH +C + + CTGPS++ G GGC+KCE+++ + + +C +G Y ++ +IS + V +C PC +C C G + + C CKG + N C C ++ K+ + C CH C+ GC + CTRC N K+++D K KF C CP ++ E + GD +CL K EET K+ ++ ++ +I V+Y + +A RI E+KA YSN EP+ K+ ED +++PPNM R+ ++ DL+F+ SKPLG GAFG VY+G WK+P+ + + L V IKVI N + ++EAK+MASVSH HCL IGVCLS EKPCL+S Y + GSLDK+L +N KI+S ML W++QIADGM YL KR IIHRDLAARNVLV+ + +QITDFGL+++++ T D I+IK+GKVPIRWLAIETL YS TDVWAYGVTLWEIFT+ K PYE+ AT +I F+ +G RL QP+I +L+VY++M+ CWL+ P++RP F L+ TF + ++P R+L
Sbjct: 17 NGSNFNPDYPNFRICVVSEAH-GSFKTPAEAYKYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVT--LRNEPDALNIIHNHSENG-TFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTGEDGVRSQFCFGPSKNECQKQTKCVK--NKDLKWCKFTKTGEIPC-SHECAGGCDGRTSKDCTVCNKLVKDSDCVSSC-APRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNLATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTFRTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKY------IEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEIS---------PDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF--ASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTSNNQYLCHKGSCPKGFYQSVINQ-NISHLHKKIVHQSSCEPCHSMCRTCSGPTNEKRMCHQCKGYFLDNKCVKECDNMKNVTMKL-EIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQ--DGDFICL-------KFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYIN-------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDET-DDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 1164
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 567.385 bits (1461), Expect = 7.008e-177 Identity = 402/1175 (34.21%), Postives = 588/1175 (50.04%), Query Frame = 2
Query: 263 NCTHIQGSIYILGI-TKLESKERELNFDS-IEEIDGHLIIEGNDLEKITFKNLRIIRGANSI-KRNLIDKGHTDFSLVVSGNAHLVD-----LDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYEN-----LNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQ-KLCYMNIPVNELFKNV-------------KNFYYIPSNCTDK--ICHKDC-SEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFY-NPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLND-SKACLPCHPNCSEYNST---ICTGPSSVPGIGGCNKCERILLSRKADIVSCVK-TCHEGTYAF----PNDRPDISRFYPVTGFTCL--PCPELCSKC------KGKSPKND--ECEVCKGVWHKNTCRLRCPRDESY--GTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKK--KFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKN--EETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLS 3610
NCTH+ G+I+I + ++ E +L F S I+EI G L I +++ + +NLR+IRG + + + + F + + + + + +D RSLRSI + N+ S + +++WNEL DP Q + + KC + K FCWGP +QCQ + C + + C ++ CCN QCLGGC +S C AC+ +L+ C C + + G NK FR C +CP +L + C +C+ ++ + + C+ C +C C L +I D ++ L L +L NC G++ + +SFVKH + + + L L+ + G S + D + S +P + + I T + +LGLKSLK I FFKN KLCY +I + FKN+ N P C + +C C S+ GCWGPG C C C +C + G+ NP ++S + CL+CH EC TC G +QCI GCK+ EN CV CS+ + LN +K C PCH +C + T +CTGPS+ PG GGCNKC+ ++L R + C + T G ++ N P + T + PC +LCS+C + K D C CKG W + C CP+ ++ + S+ C CH C GCYG +C C N K+ ++ F C ++CP + +E S + +C+ ++ S +L + ++ + I VII + TI+ +R +LKA +SN E +S+ PPNM L+++S ++L F + LG G FG VY GKWK+ ++ + D + V IKV+ + ++ M E ++MASV H HCLR IGV + LIS+Y+ GS++K+L +NK +T I+L W+EQIA+GMLYL +IIHRDLA RNVL+ + VQITDFGLSK++ KD E+ I G VP+RWLAIETL DG YSH+TDVWAY VTLWEIFTF VPYE H+I D ++KG RL QPDICSLD+YI+M+ CW P RP+F+ L F +Y N YLS
Sbjct: 69 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGK------SGFCWGPLTSQCQIFSKCRKRMCA--NRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPC-KILCEQ---ICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISG--SVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST--SLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDI---KKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTS----KVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCP--SNYKETSGNSNENICVFVFLSGWEL--------ALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPS----PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ--NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKD-EMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLS 1199
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 566.614 bits (1459), Expect = 9.448e-177 Identity = 402/1175 (34.21%), Postives = 588/1175 (50.04%), Query Frame = 2
Query: 263 NCTHIQGSIYILGI-TKLESKERELNFDS-IEEIDGHLIIEGNDLEKITFKNLRIIRGANSI-KRNLIDKGHTDFSLVVSGNAHLVD-----LDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELC--RGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYEN-----LNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQ-KLCYMNIPVNELFKNV-------------KNFYYIPSNCTDK--ICHKDC-SEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFY-NPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLND-SKACLPCHPNCSEYNST---ICTGPSSVPGIGGCNKCERILLSRKADIVSCVK-TCHEGTYAF----PNDRPDISRFYPVTGFTCL--PCPELCSKC------KGKSPKND--ECEVCKGVWHKNTCRLRCPRDESY--GTKIIDSISYCKTCHSSCKGCYGSTIFNCTRCKNKKIYLDKK--KFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKN--EETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLS 3610
NCTH+ G+I+I + ++ E +L F S I+EI G L I +++ + +NLR+IRG + + + + F + + + + + +D RSLRSI + N+ S + +++WNEL DP Q + + KC + K FCWGP +QCQ + C + + C ++ CCN QCLGGC +S C AC+ +L+ C C + + G NK FR C +CP +L + C +C+ ++ + + C+ C +C C L +I D ++ L L +L NC G++ + +SFVKH + + + L L+ + G S + D + S +P + + I T + +LGLKSLK I FFKN KLCY +I + FKN+ N P C + +C C S+ GCWGPG C C C +C + G+ NP ++S + CL+CH EC TC G +QCI GCK+ EN CV CS+ + LN +K C PCH +C + T +CTGPS+ PG GGCNKC+ ++L R + C + T G ++ N P + T + PC +LCS+C + K D C CKG W + C CP+ ++ + S+ C CH C GCYG +C C N K+ ++ F C ++CP + +E S + +C+ ++ S +L + ++ + I VII + TI+ +R +LKA +SN E +S+ PPNM L+++S ++L F + LG G FG VY GKWK+ ++ + D + V IKV+ + ++ M E ++MASV H HCLR IGV + LIS+Y+ GS++K+L +NK +T I+L W+EQIA+GMLYL +IIHRDLA RNVL+ + VQITDFGLSK++ KD E+ I G VP+RWLAIETL DG YSH+TDVWAY VTLWEIFTF VPYE H+I D ++KG RL QPDICSLD+YI+M+ CW P RP+F+ L F +Y N YLS
Sbjct: 61 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGK------SGFCWGPLTSQCQIFSKCRKRMCA--NRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPC-KILCEQ---ICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISG--SVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST--SLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDI---KKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTS----KVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCP--SNYKETSGNSNENICVFVFLSGWEL--------ALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQT----PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ--NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKD-EMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLS 1191
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1) HSP 1 Score: 543.117 bits (1398), Expect = 6.699e-167 Identity = 397/1243 (31.94%), Postives = 632/1243 (50.84%), Query Frame = 2
Query: 155 EEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRS--KNCTHIQGSIYILGITKLESKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDK---CSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYING--EEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTE-----DSFVKHNITVE---MLYENLNKLQELEGGFSYFKDNHXXXXXXXXXXXXXXXXXXHSDIPNLPSYHKFAI---SETELEFLGLKSLKEI-NGPFRFFKNQKLCYMNIPVNELFKNVKNFYYI----PSNCTDKICHKDCSEK-GCWGPGNKLCYECRKY--DAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECL---NTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSEYNS---TICTGPSSVPGIGGCNKCERILLSRKA----------DIVSCVKT---CHEGTY--------------AFPNDRPDISRFYPV-------TGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSI---SYCKTCHSSC-KGCYGSTIFNCTRCKNKKIYLD-KKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHXXXXXXXXXXXXXXXXXXXXXXYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWK-----IPKNEETL---LKKASGD--FYLPVAIKVIKNMGN-EEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGDPYEIP 3637
++ Y +C++ QI+ +S E LK R+ KNC++I G + I IT E +SIE+I G+L+I N +E I+ L++IRG N L+ KG FSL+V N+ L ++ F +L+ I HNV F++NPK+ Y I WN L + +++ T KD L ++ C + C+ A+ + +CWG S++ CQ+ C ++ + T C YIN + + CC+++C+GGC G S+C ACKN N CVE C + I N + + C +CP E+ CV +CS + C+ C C + + D Y+ + L +L+NC G I++ D+F HN++ + + ++L KL+ LE + Y + H+ + + L F N+ S+ I L++LGL++LKE+ NG F N +LC+ N N+ + F NC+ K CH +C ++ GCWGP C +C+ + + TC+S CS + G++ +S N+ C RCH ECL NTC G N N+C GCKN + +C+ C +Y ++ K C PCH NC+E + ++C GP G GC+ C I++S +I+ C+K C +G Y A + + ++ + C PC CS+C G S + C +CK N C +CP++ Y + ++ S CK CH C +GC GST ++C RCK+ KIY++ +F+CN TC + + + +I+C R ++ + + I++ V + + L K ++ +T+L + + +L PNM L+++++ L ++ +G GAFG VYKG W+ I K+ L + K S D L VA+K++ ++ + +++EAK+MASV H CLR + VCL+ P LI+ ++ GSL +F+ RN++ I S+ +L W++QIA GM YL + IIH DLAARNVL+ V+ITDFGL+KML+ ++ ++ K G++PI+WLA+E + + +S ++DVW+YGVTLWE+F++G+ P+ D +DI + + KG RL+QP ICS+D Y I+V CWL P+ RP F L +TF NP RYL +Q + P
Sbjct: 70 DKRYRHGKVCKSTQTQIDVSKNSYESLK-----RNFDKNCSYIIGDVVIAHITN----ENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENP----LLIKG-LKFSLIVGYNSMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQ-EVVIVETNEKDCGLNNEELSCHESCQ--AHLNKTYCWGNSSSACQKINDCANRTCYDSTKC-YINEILKTEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPK------ICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNF--HNLSKQNDGIRKQDLKKLENLEEIYGYLRI-HVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYY--VDSMKNCYPCHTNCTENSQNKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKVNAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWH--CSLCKYFRSDNKCIQKCPKE--YFITVNETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGSTQFFCNSTCGDRIQLFQ----TSEIICTDHLI-------YSRFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVL---PNMATLLLITESQLTRQE---IIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLT-AHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQ-QQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQDEDSNEP 1260 The following BLAST results are available for this feature:
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004568 ID=SMED30004568|Name=Receptor protein-tyrosine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4710bpback to top protein sequence of SMED30004568-orf-1 >SMED30004568-orf-1 ID=SMED30004568-orf-1|Name=SMED30004568-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1480bp MTHKTYLILFLFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
