Placenta-specific gene 8 protein

Overview
NamePlacenta-specific gene 8 protein
Smed IDSMED30004562
Length (bp)830
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Placenta-specific gene 8 protein (SMED30004562) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Placenta-specific gene 8 protein (SMED30004562) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004562

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30004562h1SMcG0005183 SmedASXL_067535SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30004562h1SMcG0005183 dd_Smed_v4_20106_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30004562h1SMcG0005183 dd_Smed_v6_20106_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Human
Match: PLAC8L1 (PLAC8 like 1 [Source:HGNC Symbol;Acc:HGNC:31746])

HSP 1 Score: 47.7506 bits (112), Expect = 3.419e-6
Identity = 36/120 (30.00%), Postives = 57/120 (47.50%), Query Frame = 1 
Query:  112 LPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            +P + V+ QP     G  T+    Q         WS+ LF  C D   C+  L    C  C +   + E +C PL   S+  L R   R RH+I+GT+  D   ++CC+  ++CQ+ R++
Sbjct:   43 VPASAVVKQPVRGASGRTTITAIVQTGG-----GWSTGLFSVCRDRRICFCGLFCPMCLECDIARHYGECLCWPLLPGSTFAL-RIGTRERHKIQGTLCEDWLAVHCCWAFSICQVAREL 156
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Match: CU499336.2 (pep chromosome:GRCz11:16:36095663:36099492:-1 gene:ENSDARG00000114387.1 transcript:ENSDART00000180905.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CU499336.2)

HSP 1 Score: 47.7506 bits (112), Expect = 9.993e-7
Identity = 37/117 (31.62%), Postives = 52/117 (44.44%), Query Frame = 1 
Query:  121 NTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            N VI QPG  +YG     +Q          +WS+ L  CC D   C L         CY  +K+ E VC     P  +  +RT  R  + I+GTI  DA    CC +   C++ R++
Sbjct:    3 NPVITQPGAGSYGTN---VQTG--------EWSTGLCSCCSDLLVCALGFFCPIALGCYTANKYGENVC-LACVPGGMAAMRTHMRLTYGIQGTICNDALMTCCCGMFETCRMAREI 107
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Match: plac8.2 (placenta associated 8, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-070424-12])

HSP 1 Score: 46.9802 bits (110), Expect = 1.274e-6
Identity = 30/100 (30.00%), Postives = 49/100 (49.00%), Query Frame = 1 
Query:  175 IQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMD 474
            +  QP     P+++ + L  CCED + C   L    C  C + S  NE            + +R+ +R ++ I+G++  D C +Y C  C  CQLKRD++
Sbjct:    3 VTSQPAAFG-PQEFQTGLMSCCEDMSICCCGLFCLPCMGCSIASDMNE-----CCLCGLGMPMRSVYRTKYNIQGSMCTDFCIVYNCMPCAACQLKRDIE 96
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Match: plac8.2 (placenta associated 8, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-070424-12])

HSP 1 Score: 46.9802 bits (110), Expect = 1.274e-6
Identity = 30/100 (30.00%), Postives = 49/100 (49.00%), Query Frame = 1 
Query:  175 IQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMD 474
            +  QP     P+++ + L  CCED + C   L    C  C + S  NE            + +R+ +R ++ I+G++  D C +Y C  C  CQLKRD++
Sbjct:    3 VTSQPAAFG-PQEFQTGLMSCCEDMSICCCGLFCLPCMGCSIASDMNE-----CCLCGLGMPMRSVYRTKYNIQGSMCTDFCIVYNCMPCAACQLKRDIE 96
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Match: ponzr5 (plac8 onzin related protein 5 [Source:ZFIN;Acc:ZDB-GENE-081104-325])

HSP 1 Score: 45.8246 bits (107), Expect = 4.414e-6
Identity = 35/114 (30.70%), Postives = 54/114 (47.37%), Query Frame = 1 
Query:  172 IIQQQPNQRNLPR---DWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-----XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEET 489
            +  QQP Q  + +    WSS +  CC++   C  S     C+ C    KH E +C PL        +  L +R   R+R+ IKG+I  D      C  C+ CQ+ R+M+  E++
Sbjct:    1 MTTQQPGQFMIAQTNDQWSSGICDCCDNVPECCFSFWCFPCFACSTARKHGECLCLPLLDGFGFIPAITLAMRVSVRSRYGIKGSICKDCAYSTFCGACSWCQISREMNIREQS 114
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Match: ponzr5 (plac8 onzin related protein 5 [Source:ZFIN;Acc:ZDB-GENE-081104-325])

HSP 1 Score: 45.8246 bits (107), Expect = 4.713e-6
Identity = 35/114 (30.70%), Postives = 54/114 (47.37%), Query Frame = 1 
Query:  172 IIQQQPNQRNLPR---DWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-----XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEET 489
            +  QQP Q  + +    WSS +  CC++   C  S     C+ C    KH E +C PL        +  L +R   R+R+ IKG+I  D      C  C+ CQ+ R+M+  E++
Sbjct:    4 MTTQQPGQFMIAQTNDQWSSGICDCCDNVPECCFSFWCFPCFACSTARKHGECLCLPLLDGFGFIPAITLAMRVSVRSRYGIKGSICKDCAYSTFCGACSWCQISREMNIREQS 117
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Xenopus
Match: pskh2 (protein serine kinase H2 [Source:Xenbase;Acc:XB-GENE-957157])

HSP 1 Score: 53.5286 bits (127), Expect = 1.553e-7
Identity = 30/93 (32.26%), Postives = 50/93 (53.76%), Query Frame = 1 
Query:  202 LPRDWSSELFGCCEDCTSCWLSL---CFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            +P  W+++ F C  D  +C L     C   CYL  L+++     C   F P ++  +RT  R RH+I+G+++ D   I CC +C  CQ+ R++
Sbjct:  340 VPVSWTTDFFNCFADLKTCLLGTVCPCIMPCYLSKLFNE----TCFLGFLPGAMCSMRTGIRERHKIQGSLLQDYGAICCCPLCATCQVAREI 428
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Mouse
Match: Plac8l1 (PLAC8-like 1 [Source:MGI Symbol;Acc:MGI:1916651])

HSP 1 Score: 51.9878 bits (123), Expect = 1.070e-7
Identity = 39/120 (32.50%), Postives = 57/120 (47.50%), Query Frame = 1 
Query:  112 LPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            +P   V+ QP     G  TV    Q        DWS+ LF  C D   C+  L    C  C +   + E +C PL   S+  L R   R RHRI+GT+  D   ++CC+  ++CQ+ R++
Sbjct:   43 VPARVVVKQPIRGAIGRTTVAAIVQTGG-----DWSTGLFSVCRDRKICFWGLLCPMCLECDIARHYGECLCWPLLPGSTFAL-RIGTRERHRIQGTLCEDCVVVHCCWPFSICQVAREL 156
[Close]
BLAST of Placenta-specific gene 8 protein vs. UniProt/SwissProt
Match: sp|Q08EJ0|PL8L1_MOUSE (PLAC8-like protein 1 OS=Mus musculus OX=10090 GN=Plac8l1 PE=2 SV=2)

HSP 1 Score: 51.9878 bits (123), Expect = 7.481e-7
Identity = 39/120 (32.50%), Postives = 57/120 (47.50%), Query Frame = 1 
Query:  112 LPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            +P   V+ QP     G  TV    Q        DWS+ LF  C D   C+  L    C  C +   + E +C PL   S+  L R   R RHRI+GT+  D   ++CC+  ++CQ+ R++
Sbjct:   43 VPARVVVKQPIRGAIGRTTVAAIVQTGG-----DWSTGLFSVCRDRKICFWGLLCPMCLECDIARHYGECLCWPLLPGSTFAL-RIGTRERHRIQGTLCEDCVVVHCCWPFSICQVAREL 156
[Close]
BLAST of Placenta-specific gene 8 protein vs. UniProt/SwissProt
Match: sp|Q3ZCB2|PLAC8_BOVIN (Placenta-specific gene 8 protein OS=Bos taurus OX=9913 GN=PLAC8 PE=3 SV=1)

HSP 1 Score: 47.7506 bits (112), Expect = 7.335e-6
Identity = 34/111 (30.63%), Postives = 54/111 (48.65%), Query Frame = 1 
Query:  157 GNQTVIIQQQPNQRNLP----RDWSSELFGCCEDCTSCWL-SLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMD 474
             +  V+I  QP   + P     +W + L  C  DC  C   + CF  C  C + S  NE          + + +RT +R R+ I G+I  D    +CC +C++CQ+KRD++
Sbjct:    4 ASSPVVIVTQPGVGSGPAPQNSNWQTGLCDCFSDCGVCLCGTFCFT-CLACQVASDMNE-----CCLCGTSVAMRTLYRTRYGIPGSICDDFMVTHCCPLCSLCQIKRDIN 108
[Close]
BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Match: A0A074Z7Z6 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_08775 PE=4 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 2.678e-20
Identity = 51/119 (42.86%), Postives = 69/119 (57.98%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            P Y  +  ++ +QP +    RDW   L+ C  DC SCW  LC   CY+C +Y ++ E   TP+      L+LR+ HRA+H I+GT+ GD    YCC +C  CQL RDM YVE T G L+
Sbjct:   45 PNYSLKFEMVTEQPRKVLPKRDWIDGLYSCTNDCRSCWCVLCCYPCYMCSMYRRYGECCGTPMGIVFPGLVLRSYHRAKHNIQGTLCGDCAVDYCCTLCAACQLDRDMKYVESTTGILN 163
[Close]
BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Match: A0A1S8WL90 (Putative Cys-rich domain protein OS=Opisthorchis viverrini OX=6198 GN=X801_09003 PE=4 SV=1)

HSP 1 Score: 91.6633 bits (226), Expect = 1.270e-19
Identity = 49/111 (44.14%), Postives = 66/111 (59.46%), Query Frame = 1 
Query:  172 IIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            ++ +QP +    RDW   L+ C  DC SCW  LC   CY+C +Y ++ E   TP+      L+LR+ HRA+H I+GT+ GD    YCC +C  CQL RDM YVE T G L+
Sbjct:    1 MVTEQPRKVLPKRDWIDGLYSCTNDCRSCWCVLCCYPCYMCSMYRRYGECCGTPMGIVFPGLVLRSYHRAKHNIQGTLCGDCAVDYCCTLCAACQLDRDMKYVESTTGILN 111
[Close]
BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Match: A0A504YXV3 (Placenta-specificprotein 8 protein OS=Fasciola gigantica OX=46835 GN=FGIG_07833 PE=4 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 2.361e-19
Identity = 51/110 (46.36%), Postives = 63/110 (57.27%), Query Frame = 1 
Query:  175 IQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            +  QP    + RDW   LF C  DC SCW  LC   CY+C +YS+++E   TPL      L LR  HRA+H I+GTI  D    YCC  C  CQL RDM +VE+T G L+
Sbjct:    5 VTTQPGFPVIKRDWHDGLFDCTNDCHSCWCILCCYPCYMCQMYSRYDECCGTPLAMIFPGLTLRVYHRAKHNIEGTIFNDCLVDYCCTPCAACQLDRDMTFVEQTKGLLN 114
[Close]
BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Match: A0A2H1CXP3 (Placenta-specificprotein 8 protein OS=Fasciola hepatica OX=6192 GN=D915_000062 PE=4 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 2.361e-19
Identity = 51/110 (46.36%), Postives = 63/110 (57.27%), Query Frame = 1 
Query:  175 IQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            +  QP    + RDW   LF C  DC SCW  LC   CY+C +YS+++E   TPL      L LR  HRA+H I+GTI  D    YCC  C  CQL RDM +VE+T G L+
Sbjct:    5 VTTQPGFPVIKRDWHDGLFDCTNDCHSCWCILCCYPCYMCQMYSRYDECCGTPLAMIFPGLTLRVYHRAKHNIEGTIFNDCLVDYCCTPCAACQLDRDMTFVEQTKGLLN 114
[Close]
BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Match: Q5DB80 (Placenta-specific 8 protein isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_009191 PE=2 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 2.371e-19
Identity = 49/99 (49.49%), Postives = 60/99 (60.61%), Query Frame = 1 
Query:  208 RDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            RDW   LF C  DC SCWL  C   CY+CY+Y +++E   TP       L LR  HRA+H I GT+  D  K YCC +C+ CQL RDM YVE T+G L+
Sbjct:   15 RDWHDGLFDCTNDCASCWLIFCCYPCYMCYMYRRYDECWATPCLILFPGLTLRAYHRAKHNIHGTLCKDWLKDYCCPLCSACQLDRDMKYVEATSGILN 113
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Match: ponzr6 (cornifelin homolog [Source:NCBI gene;Acc:103028345])

HSP 1 Score: 51.6026 bits (122), Expect = 4.858e-8
Identity = 38/117 (32.48%), Postives = 52/117 (44.44%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-------XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            PT   Q V  Q   NQR +   WSS +  CCED   C        C +C    K+ E +C PL               +R+  R R+ I+G++  D C   CC IC  CQ+ R++ Y
Sbjct:    4 PTVIVQPVAFQPPDNQRIV--QWSSGICDCCEDMGICCFGFWCPYCLMCNTTKKYGECMCLPLVELCFGGLIPPVTYSMRSSMRERYHIQGSMCDDCCVSTCCGICAWCQIARELKY 118
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Match: ponzr6 (cornifelin homolog [Source:NCBI gene;Acc:103028345])

HSP 1 Score: 51.9878 bits (123), Expect = 5.089e-8
Identity = 38/117 (32.48%), Postives = 52/117 (44.44%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-------XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            PT   Q V  Q   NQR +   WSS +  CCED   C        C +C    K+ E +C PL               +R+  R R+ I+G++  D C   CC IC  CQ+ R++ Y
Sbjct:    4 PTVIVQPVAFQPPDNQRIV--QWSSGICDCCEDMGICCFGFWCPYCLMCNTTKKYGECMCLPLVELCFGGLIPPVTYSMRSSMRERYHIQGSMCDDCCVSTCCGICAWCQIARELKY 118
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Match: ponzr6 (cornifelin homolog [Source:NCBI gene;Acc:103028345])

HSP 1 Score: 51.9878 bits (123), Expect = 5.089e-8
Identity = 38/117 (32.48%), Postives = 52/117 (44.44%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-------XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            PT   Q V  Q   NQR +   WSS +  CCED   C        C +C    K+ E +C PL               +R+  R R+ I+G++  D C   CC IC  CQ+ R++ Y
Sbjct:    4 PTVIVQPVAFQPPDNQRIV--QWSSGICDCCEDMGICCFGFWCPYCLMCNTTKKYGECMCLPLVELCFGGLIPPVTYSMRSSMRERYHIQGSMCDDCCVSTCCGICAWCQIARELKY 118
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Match: ponzr6 (cornifelin homolog [Source:NCBI gene;Acc:103028345])

HSP 1 Score: 51.2174 bits (121), Expect = 5.855e-8
Identity = 38/117 (32.48%), Postives = 52/117 (44.44%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-------XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            PT   Q V  Q   NQR +   WSS +  CCED   C        C +C    K+ E +C PL               +R+  R R+ I+G++  D C   CC IC  CQ+ R++ Y
Sbjct:    4 PTVIVQPVAFQPPDNQRIV--QWSSGICDCCEDMGICCFGFWCPYCLMCNTTKKYGECMCLPLVELCFGGLIPPVTYSMRSSMRERYHIQGSMCDDCCVSTCCGICAWCQIARELKY 118
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Match: ponzr6 (cornifelin homolog [Source:NCBI gene;Acc:103028345])

HSP 1 Score: 48.1358 bits (113), Expect = 1.072e-6
Identity = 39/119 (32.77%), Postives = 53/119 (44.54%), Query Frame = 1 
Query:  148 PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCED--CTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXX-------XXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            PT   Q V  Q   NQR +   WSS +  CCED  C   W   C     +C    K+ E +C PL               +R+  R R+ I+G++  D C   CC IC  CQ+ R++ Y
Sbjct:    4 PTVIVQPVAFQPPDNQRIV--QWSSGICDCCEDMGCFGFWCPYCL----MCNTTKKYGECMCLPLVELCFGGLIPPVTYSMRSSMRERYHIQGSMCDDCCVSTCCGICAWCQIARELKY 116
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009354.1 (pep scaffold:Pmarinus_7.0:GL483774:7229:14014:-1 gene:ENSPMAG00000008464.1 transcript:ENSPMAT00000009354.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 43.8986 bits (102), Expect = 4.503e-6
Identity = 28/88 (31.82%), Postives = 42/88 (47.73%), Query Frame = 1 
Query:  214 WSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDY 477
            WSS +  C +D   C           C + S   E  C P+   + + L RT  R RH I+GT+  D   ++CC  CT CQ+ R++ +
Sbjct:   23 WSSHMMDCFQDTEICVCGFFCLPLLQCKVASDFGECFCVPMLPGALMAL-RTGIRERHHIEGTVFDDFVSLWCCNHCTTCQMARELRH 109
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Nematostella
Match: EDO42647 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0V8])

HSP 1 Score: 50.8322 bits (120), Expect = 2.672e-8
Identity = 36/117 (30.77%), Postives = 53/117 (45.30%), Query Frame = 1 
Query:  139 PGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXX-XXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEE 486
            PG  TY      I QQ       RDWSS LF C +D   C ++       LC +  +  E +         +   LR K R    I+G++  DA  + CC  C +CQ+ R++D+V +
Sbjct:   17 PGTTTY-----TIGQQ-------RDWSSGLFECTKDIGGCLVTFLCPCVTLCQISQRMGEGLAYGCCCADIAAFTLRAKLRTEQNIQGSLCNDAIHVSCCMHCALCQMSRELDHVGK 121
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Nematostella
Match: EDO42612 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0W1])

HSP 1 Score: 48.9062 bits (115), Expect = 2.187e-7
Identity = 33/92 (35.87%), Postives = 50/92 (54.35%), Query Frame = 1 
Query:  208 RDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKH-NEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYV 480
            RDW S + GC +D  SC L   F  C+L    S+   E  C P   P +L+ LR K R    I+G+++ D C + C  +C +CQL R++ ++
Sbjct:   52 RDWHSGMCGCFDDIGSCLLGY-FCPCFLLIDVSQRMGEGCCFPCCCPGALVGLRVKLRVEQNIQGSLINDYCAVQCLPLCVLCQLSRELKHL 142
[Close]
BLAST of Placenta-specific gene 8 protein vs. Ensembl Medaka
Match: ENSORLT00000028572.1 (cornifelin homolog [Source:NCBI gene;Acc:101172524])

HSP 1 Score: 48.521 bits (114), Expect = 3.888e-7
Identity = 34/115 (29.57%), Postives = 49/115 (42.61%), Query Frame = 1 
Query:  127 VIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM 471
            V  QPG   YG     +Q          +WS+ L  C  DC  C L         CY   K+ E  C          + RT  R  + I+GT+  DA  ++CC +C MC++ R++
Sbjct:    6 VTHQPGAGGYGTN---VQTG--------EWSTGLCSCFNDCLICALGFFCPAGLSCYTAHKYGENFCLGCVPGGMTAM-RTHMRLTYGIQGTVCNDAIMVFCCGLCEMCRMAREI 108
[Close]
BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Match: SMESG000050175.1 (SMESG000050175.1)

HSP 1 Score: 261.151 bits (666), Expect = 5.218e-89
Identity = 137/138 (99.28%), Postives = 138/138 (100.00%), Query Frame = 1 
Query:   91 MQYDNNGLPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            MQYDNNGLPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCTPLFTPSSLLLLRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDM+YVEETNGSLD
Sbjct:    1 MQYDNNGLPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCTPLFTPSSLLLLRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMNYVEETNGSLD 138
[Close]
BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Match: SMESG000050177.1 (SMESG000050177.1)

HSP 1 Score: 149.828 bits (377), Expect = 3.064e-45
Identity = 84/141 (59.57%), Postives = 100/141 (70.92%), Query Frame = 1 
Query:   91 MQYDNNGLPCNTVIIQPGV---PTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
            MQYDN G     V++QPGV   P   NQT +I QQP   N PR WSS + GCCEDCTSC L++ F  CY CYL+  ++EF+CTP+    S+L LRTKHRARH I+GTI+ D CK Y CY C +CQLKRDMDYVE+T GSLD
Sbjct:    1 MQYDNRGFLPTPVLVQPGVMANPMNINQTTVIIQQP-VANGPRLWSSGICGCCEDCTSCCLTMFFTHCYTCYLFHIYDEFLCTPICMYDSVLQLRTKHRARHGIRGTIIEDCCKTYWCYWCAICQLKRDMDYVEDTKGSLD 140
[Close]
BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Match: SMESG000050244.1 (SMESG000050244.1)

HSP 1 Score: 123.25 bits (308), Expect = 3.746e-35
Identity = 76/128 (59.38%), Postives = 90/128 (70.31%), Query Frame = 1 
Query:  121 NTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
              +I QPG   + NQ VI +Q    R   R+WSS LF CC+DCTSC L     ECYLCY+Y  + EFVCTPLFTP+S LLLRTKHR+R+ IKG+I+ D C  Y CY C MCQLKRDMDYVE+ NG L+
Sbjct:    3 TVIITQPG---HKNQ-VITRQDQIPRTTYRNWSSGLFDCCDDCTSCVLIAFCPECYLCYMYHIYYEFVCTPLFTPASTLLLRTKHRSRNHIKGSIIADCCLTYWCYFCAMCQLKRDMDYVEDKNGYLE 126
[Close]
BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Match: SMESG000050244.1 (SMESG000050244.1)

HSP 1 Score: 122.865 bits (307), Expect = 5.355e-35
Identity = 76/130 (58.46%), Postives = 90/130 (69.23%), Query Frame = 1 
Query:  121 NTVIIQPGVPTYGNQT--VIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
              +I QPG   + NQ   VI +Q    R   R+WSS LF CC+DCTSC L     ECYLCY+Y  + EFVCTPLFTP+S LLLRTKHR+R+ IKG+I+ D C  Y CY C MCQLKRDMDYVE+ NG L+
Sbjct:    3 TVIITQPG---HKNQVAPVITRQDQIPRTTYRNWSSGLFDCCDDCTSCVLIAFCPECYLCYMYHIYYEFVCTPLFTPASTLLLRTKHRSRNHIKGSIIADCCLTYWCYFCAMCQLKRDMDYVEDKNGYLE 129
[Close]
BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Match: SMESG000050245.1 (SMESG000050245.1)

HSP 1 Score: 122.094 bits (305), Expect = 1.233e-34
Identity = 73/128 (57.03%), Postives = 87/128 (67.97%), Query Frame = 1 
Query:  121 NTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCCEDCTSCWLSLCFAECYLCYLYSKHNEFVCXXXXXXXXXXXXRTKHRARHRIKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD 504
               + QPG    GNQ +  Q Q  +    R+WSS LF CC+DC SCW      ECYLCY+Y  + EFVCTPLFTP+S LLLRTKHR+R+ IKG+I+ D C  Y CY C MCQLKRDMDYVE+ NG L+
Sbjct:    3 TVFVTQPGQ---GNQAITRQNQIAEPTY-RNWSSGLFDCCDDCASCWCVTFCPECYLCYMYHIYYEFVCTPLFTPASTLLLRTKHRSRNHIKGSIIADCCLTYWCYFCAMCQLKRDMDYVEDKNGYLE 126
The following BLAST results are available for this feature:
BLAST of Placenta-specific gene 8 protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
PLAC8L13.419e-630.00PLAC8 like 1 [Source:HGNC Symbol;Acc:HGNC:31746][more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CU499336.29.993e-731.62pep chromosome:GRCz11:16:36095663:36099492:-1 gene... [more]
plac8.21.274e-630.00placenta associated 8, tandem duplicate 2 [Source:... [more]
plac8.21.274e-630.00placenta associated 8, tandem duplicate 2 [Source:... [more]
ponzr54.414e-630.70plac8 onzin related protein 5 [Source:ZFIN;Acc:ZDB... [more]
ponzr54.713e-630.70plac8 onzin related protein 5 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pskh21.553e-732.26protein serine kinase H2 [Source:Xenbase;Acc:XB-GE... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Plac8l11.070e-732.50PLAC8-like 1 [Source:MGI Symbol;Acc:MGI:1916651][more]
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BLAST of Placenta-specific gene 8 protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q08EJ0|PL8L1_MOUSE7.481e-732.50PLAC8-like protein 1 OS=Mus musculus OX=10090 GN=P... [more]
sp|Q3ZCB2|PLAC8_BOVIN7.335e-630.63Placenta-specific gene 8 protein OS=Bos taurus OX=... [more]
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BLAST of Placenta-specific gene 8 protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A074Z7Z62.678e-2042.86Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A1S8WL901.270e-1944.14Putative Cys-rich domain protein OS=Opisthorchis v... [more]
A0A504YXV32.361e-1946.36Placenta-specificprotein 8 protein OS=Fasciola gig... [more]
A0A2H1CXP32.361e-1946.36Placenta-specificprotein 8 protein OS=Fasciola hep... [more]
Q5DB802.371e-1949.49Placenta-specific 8 protein isoform 1 OS=Schistoso... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ponzr64.858e-832.48cornifelin homolog [Source:NCBI gene;Acc:103028345... [more]
ponzr65.089e-832.48cornifelin homolog [Source:NCBI gene;Acc:103028345... [more]
ponzr65.089e-832.48cornifelin homolog [Source:NCBI gene;Acc:103028345... [more]
ponzr65.855e-832.48cornifelin homolog [Source:NCBI gene;Acc:103028345... [more]
ponzr61.072e-632.77cornifelin homolog [Source:NCBI gene;Acc:103028345... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000009354.14.503e-631.82pep scaffold:Pmarinus_7.0:GL483774:7229:14014:-1 g... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO426472.672e-830.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO426122.187e-735.87Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Placenta-specific gene 8 protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSORLT00000028572.13.888e-729.57cornifelin homolog [Source:NCBI gene;Acc:101172524... [more]
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BLAST of Placenta-specific gene 8 protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000050175.15.218e-8999.28SMESG000050175.1[more]
SMESG000050177.13.064e-4559.57SMESG000050177.1[more]
SMESG000050244.13.746e-3559.38SMESG000050244.1[more]
SMESG000050244.15.355e-3558.46SMESG000050244.1[more]
SMESG000050245.11.233e-3457.03SMESG000050245.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004562 ID=SMED30004562|Name=Placenta-specific gene 8 protein|organism=Schmidtea mediterranea sexual|type=transcript|length=830bp
TGAATCTATAGTAAATATTAATGCAAGCTTGATACTATAAATTTTGGAGT
CTCGTATCAAAATTAAAACGCCTATAAAAATTTATACAGAATGCAATACG
ATAACAATGGATTACCTTGCAATACTGTAATTATTCAACCCGGCGTTCCA
ACATATGGAAATCAGACTGTTATTATACAGCAACAACCAAACCAAAGAAA
CCTTCCTAGAGACTGGAGTTCTGAACTTTTTGGATGCTGCGAAGATTGTA
CATCATGTTGGCTCTCACTATGCTTCGCCGAGTGCTATTTGTGTTATTTG
TATAGTAAACACAATGAGTTTGTTTGTACACCTTTATTCACACCTTCCTC
ACTATTACTATTGAGAACTAAGCACCGAGCTCGGCATCGGATTAAAGGTA
CAATAATGGGGGATGCTTGCAAAATATATTGTTGCTATATATGCACAATG
TGCCAACTGAAACGAGATATGGATTATGTGGAAGAAACAAATGGATCACT
TGACTAAGAAATAGACGAAATAACTAGAAATTCGCTACAATGACTTTATT
ATAGTTACAATTCTAAATTTTAAATAATTTTTTGTGTGTTTTGATATTCC
ATTTAAACAAAATTATAATAATAATATTGATAATCGAATATCTCAGGATA
AATATTAATTCGAATAAAATGTGTCCATGAGGTCTAAGGTGTCTCATAAG
TAAAATTCTTAAAACAAAAATGTTTATTTTTCATTCGGATTTTATTTATT
TTAATTTTATAATTTAATGTTTATTTTAGCGTTTGCAATTTCTGTAGGAC
AATTTTATTATCTTGGCTTAATACTACTTT
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protein sequence of SMED30004562-orf-1

>SMED30004562-orf-1 ID=SMED30004562-orf-1|Name=SMED30004562-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=139bp
MQYDNNGLPCNTVIIQPGVPTYGNQTVIIQQQPNQRNLPRDWSSELFGCC
EDCTSCWLSLCFAECYLCYLYSKHNEFVCTPLFTPSSLLLLRTKHRARHR
IKGTIMGDACKIYCCYICTMCQLKRDMDYVEETNGSLD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR006461PLAC_motif_containing
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006461PLAC8 motif-containing proteinPFAMPF04749PLAC8coord: 42..125
e-value: 7.4E-10
score: 39.7
IPR006461PLAC8 motif-containing proteinTIGRFAMTIGR01571TIGR01571coord: 40..128
e-value: 5.9E-12
score: 44.3
IPR006461PLAC8 motif-containing proteinPANTHERPTHR15907FAMILY NOT NAMEDcoord: 26..132
NoneNo IPR availablePANTHERPTHR15907:SF93PLACENTA-SPECIFIC 8, TANDEM DUPLICATE 1-RELATEDcoord: 26..132