Receptor protein-tyrosine kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30004546 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 16
Homology
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB3 (erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431]) HSP 1 Score: 237.654 bits (605), Expect = 6.427e-64 Identity = 189/651 (29.03%), Postives = 292/651 (44.85%), Query Frame = 2
Query: 524 SFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGN--VIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVV--SNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS---NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
S R + Q C L + N + L + C V+GN +++TG N +LSFL I E+TG++ + N ++ L NL+++RG +Y + KF++ V+ N + L+ L L + IL + + N + + + I W I+ + + EIV N + CH C K CWG S CQ + + C +G QCCH+EC GGC GP +T C C+HFN+ GACV +CP+ LV+N + N K+ + CV CP + ++ CV C KNG + C PC G+CPK C + Q ++ + NCT GN+ I G G+ W K I + + L ++EI G L N+ S P + F NL I + N+ + L I +N ++ LG + LKE+ G + I N +LCY SL +L +++I +N C E + C LC GCWGP C+ CR++ + +C+++C+ F N E + HE +C CH +C + TC G G+D C C +++ +C CP G N C+ CH++CT+
Sbjct: 15 SLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTG-HNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQ--VY-DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHM-DTIDWRDIV-RDRDAEIVVKDNGRSCPP-------CHEVC-----KGRCWGPGSEDCQTLT---KTICAPQCNGHCFGP-NPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGL-----KMCEPC-GGLCPKAC--EGTGSGSRFQTVDSSNIDGFVNCTKILGNL---DFLITGLNGDPWHK-IPALDPEKLNVFRTVREITGYL--NIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFS-LLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCS-SGGCWGPGPGQCLSCRNY--SRGGVCVTHCN-----FLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCA-QCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQ 619 HSP 2 Score: 63.929 bits (154), Expect = 2.352e-9 Identity = 45/206 (21.84%), Postives = 92/206 (44.66%), Query Frame = 2
Query: 3284 ILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+L G F + KG W IP+ E + + V IKV+ + S + + I S D +R++ + + +L Q GSL++ ++Q+ + +L W Q+A G Y++ G+++ ++ N+ ++SP ++ ++D G++ L ++ E K I W E+ + ++ +S V +Y
Sbjct: 714 VLGSGVFGTVHKGVW---------------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYG 898
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB3 (erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431]) HSP 1 Score: 239.195 bits (609), Expect = 3.351e-63 Identity = 189/651 (29.03%), Postives = 293/651 (45.01%), Query Frame = 2
Query: 524 SFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGN--VIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVV--SNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGV--KHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS---NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
S R + Q C L + N + L + C V+GN +++TG N +LSFL I E+TG++ + N ++ L NL+++RG +Y + KF++ V+ N + L+ L L + IL + + N + + + I W I+ + + EIV N + CH C K CWG S CQ + + C +G QCCH+EC GGC GP +T C C+HFN+ GACV +CP+ LV+N + + N K+ + CV CP + ++ CV C KNG + C PC G+CPK C + Q ++ + NCT GN+ I G G+ W K I + + L ++EI G L N+ S P + F NL I + N+ + L I +N ++ LG + LKE+ G + I N +LCY SL +L +++I +N C E + C LC GCWGP C+ CR++ + +C+++C+ F N E + HE +C CH +C + TC G G+D C C +++ +C CP G N C+ CH++CT+
Sbjct: 15 SLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTG-HNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQ--VY-DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHM-DTIDWRDIV-RDRDAEIVVKDNGRSCPP-------CHEVC-----KGRCWGPGSEDCQTLTKTI---CAPQCNGHCFGP-NPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGL-----KMCEPC-GGLCPKAC--EGTGSGSRFQTVDSSNIDGFVNCTKILGNL---DFLITGLNGDPWHK-IPALDPEKLNVFRTVREITGYL--NIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFS-LLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCS-SGGCWGPGPGQCLSCRNY--SRGGVCVTHCN-----FLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCA-QCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQ 619 HSP 2 Score: 63.1586 bits (152), Expect = 4.615e-9 Identity = 45/206 (21.84%), Postives = 92/206 (44.66%), Query Frame = 2
Query: 3284 ILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+L G F + KG W IP+ E + + V IKV+ + S + + I S D +R++ + + +L Q GSL++ ++Q+ + +L W Q+A G Y++ G+++ ++ N+ ++SP ++ ++D G++ L ++ E K I W E+ + ++ +S V +Y
Sbjct: 714 VLGSGVFGTVHKGVW---------------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYG 898
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 231.491 bits (589), Expect = 5.061e-63 Identity = 201/654 (30.73%), Postives = 289/654 (44.19%), Query Frame = 2
Query: 548 SDHQNTCI-SKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKH--QFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLS--INQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTG 2425
SD Q+ C ++ + D Y + +NC V+GN+ IT I N +LSFL S+ E+TG++ + N + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + + IHW I+ L +V + SS G CH SC CWG + CQ + R C YG + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV KCP + +++ CV C + + V E C PC + +CPK C + Q ++ + + NCT +GN+I I GD N I I + L ++EI G L N+ S P + F NL I +GLS I + + L Q LKE+ G + I +N LCY ++ ++ + ++ I +N K C E C+ LC GCWGP C+ CR F + +CI +C+ G F EN C +C QC +TC+GPG D CT C ++K C EKCP G S C CH +CT+ + S C G
Sbjct: 23 SDSQSVCAGTENKLSSLSDLEQQY-RALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLY---EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNK-FLCYADTIHWQDIVRNPWPSNLTLVSTNGSS-------GCGRCHKSCTGR-----CWGPTENHCQTL---TRTVCAEQCDGRCYGPY-VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPS-SKMEVEENGIKMCKPCTD-ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA----IEAIDPEKLNVFRTVREITGFL--NIQSWPPNMTDFSVFSNLVTIGGRVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRF--SRGRICIESCNLYDGEFREFENGSI----CVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIG 635
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 225.713 bits (574), Expect = 7.619e-62 Identity = 184/609 (30.21%), Postives = 286/609 (46.96%), Query Frame = 2
Query: 644 NCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNI-IGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCH----SSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIK--NRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNET----CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLY-FRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSN--QMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCL--SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCT 2386
NC V+GN+ IT + N +LSFL +I+E+ G++ + N+VE I L+NL+IIRG +Y E ++L V+SN + LK L + Q IL + NNP + ++ I W I+ SS+F S D H C P CWG CQ + + + S +C CCH +C GC GP + CL+C+ F ++ C + CP +++N + N K++F TCV KCP Y + ++ CV C +Y + E C C G C K C + + + +N + +NCT G++ I ++ GD P + ++L+ L +KEI G L I P +T L+ F NLEIIR T + + ++ N + LGL+ LKE+ +G V I N LCY +++ K + ++ + I +N + C+A + C LC P+ GCWGP CV CR+ ++ C+ C+ G + +C +CH +CL + NITC G G D C C +Y +C + CP G+ +T ++C CH +CT
Sbjct: 57 NCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGN---MYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV-------------SSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQ-QCSGRCRGKSP---SDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRAC-GADSYEMEEDGVRKCKKC-EGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPP----LDPQELDILKTVKEITGFLLIQA---WPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLN--ITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPE-GCWGPEPRDCVSCRN--VSRGRECVDKCNLLEG----EPREFVENSECIQCHPECLPQAMNITCTGRGPDNC-IQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT 625
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 234.187 bits (596), Expect = 8.470e-62 Identity = 197/626 (31.47%), Postives = 281/626 (44.89%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKH--QFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLS--INQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTGPGNH 2437
+NC V+GN+ IT I N +LSFL S+ E+TG++ + N + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + + IHW I+ L +V + SS G CH SC G+ CWG + CQ + R C YG + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV KCP + +++ CV C + + V E C PC + +CPK C + Q ++ + + NCT +GN+I I GD N I I + L ++EI G L N+ S P + F NL I +GLS I + + L Q LKE+ G + I +N LCY ++ ++ + ++ I +N K C A C+ LC GCWGP C+ CR F + +CI +C+ G F EN C +C QC +TC+GPG D CT C ++K C EKCP G S C CH +CT+ C GP +H
Sbjct: 28 ENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLY---EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQN-KFLCYADTIHWQDIVRNPWPSNLTLVSTNGSS-------GCGRCHKSC---TGR--CWGPTENHCQTL---TRTVCAEQCDGRCYGPY-VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPS-SKMEVEENGIKMCKPCTD-ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA----IEAIDPEKLNVFRTVREITGFL--NIQSWPPNMTDFSVFSNLVTIGGRVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRF--SRGRICIESCNLYDGEFREFENGSI----CVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQ--------GCNGPTSH 605 HSP 2 Score: 112.849 bits (281), Expect = 2.770e-24 Identity = 93/426 (21.83%), Postives = 164/426 (38.50%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDC-----------KQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E++ G+IC+ C P C + DG + ++C +C + G CV C D NS ++ + C CH C +GC G T +DC Q R + F I G F ++V + + +K+ L+ S AP+ +L + E + +L G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L+E++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 518 REFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC-PDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSI------------------------------------------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 880
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 218.779 bits (556), Expect = 2.652e-57 Identity = 272/1169 (23.27%), Postives = 466/1169 (39.86%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGI-TNE----------------------NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSIL--GKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLS-SKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLV--HNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNG----ATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIII-NTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSN------QMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQC------TFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDG---TIESCHRCK-----SHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEG--CTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVC----VQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD---IESDFAPSSTK--LLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRII--------LVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
N ++ + + C V GN+ IT I NE +++F +++EEI G L ++ +++ IS L++I G+ ++ + +L + N + + +++ + +VI ++ + +NP M Y + I W +L Q +E H K + CH SC CWG+ CQ + R C S S+CF +CC C+GGC G C+ C + G C+E CP + + H + + N ++ N CV +CP + IEN+ CV C +G AT V E C C + CPK C + +L + L LE C G++II + + E Q K LE + + E ++ N L + +NL+II +N L+I Q DDL L L LK ++ G V I+ N +LCY + SI+ S + I N CE R C K C+ K GCWG C++C+ ++ C+ C + G+ N+ + M+C +C +C TC G G C T ++ C CP H+ + N+C+ CH +C + CTGP +++G GC++C Y ++ ++ C+ SS G + ++ P N+ + E C C C CS +++ CK + + C+ C + ++ +++N ++C KCH EC + C C++CK ++ C S C N + C + ++ K G +V+ + + + W+C +R KLK + + I++ P+ ++ L+P +E Q + L G F + G + K V + V IKV +D + + L++ + L+II L +V Y L G+L FLK + + +L+ +Q+ASG Y++ + +++ D+ T N+ ++ + I+D GLSK+ IK GK+ I W E + ++ S V +
Sbjct: 66 NILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDE--VFHD--NALYIHKN----DKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMA--KCHESCNDK-----CWGSGDNDCQRV---YRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRE-CEKCRSSSCPKICTVDG--------HLTNETLKNLEGCEQIDGHLIIEHAFTYE--------------QLKVLETVKIVSEYITIVQQN-------FYDLKFLKNLQIIEGRKLHNVRW-ALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCN-KRGCWGKEPEDCLECKTWKSV--GTCVEKCDTK-GFLRNQTS-----MKCERCSPECE----TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHF--PTQKNVCEKCHPTC-------YDNGCTGPDSNLGYGGCKQCKYA-----------VKYENDTIFCLQSS-----GMNNVCVENDLP---------------------NYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNN--TVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRC--------QRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKN-------------------VKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL-------GNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAF 1085
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 218.394 bits (555), Expect = 2.840e-57 Identity = 264/1119 (23.59%), Postives = 453/1119 (40.48%), Query Frame = 2
Query: 692 ENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSIL--GKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLS-SKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLV--HNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNG----ATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIII-NTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSN------QMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYN-DY-----CTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDG---TIESCHRCK-----SHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEG--CTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVC----VQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD---IESDFAPSSTK--LLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRII--------LVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
++++F +++EEI G L ++ +++ IS L++I G+ ++ + +L + N + + +++ + +VI ++ + +NP M Y + I W +L Q +E H K + CH SC CWG+ CQ + R C S S+CF +CC C+GGC G C+ C + G C+E CP + + H + + N ++ N CV +CP + IEN+ CV C +G AT V E C C + CPK C + +L + L LE C G++II + + E Q K LE + + E ++ N L + +NL+II +N L+I Q DDL L L LK ++ G V I+ N +LCY + SI+ S + I N CE R C K C+ K GCWG C++C+ ++ C+ C + G+ N+ + M+C +C +C TC G G C YN D+ C CP H+ + N+C+ CH +C + CTGP +++G GC++C Y ++ ++ C+ SS G + ++ P N+ + E C C C CS +++ CK + + C+ C + ++ +++N ++C KCH EC + C C++CK ++ C S C N + C + ++ K G +V+ + + + W+C +R KLK + + I++ P+ ++ L+P +E Q + L G F + G + K V + V IKV +D + + L++ + L+II L +V Y L G+L FLK + + +L+ +Q+ASG Y++ + +++ D+ T N+ ++ + I+D GLSK+ IK GK+ I W E + ++ S V +
Sbjct: 43 KSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDE--VFHDN--ALYIHKN----DKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMA--KCHESCNDK-----CWGSGDNDCQRV---YRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRE-CEKCRSSSCPKICTVDG--------HLTNETLKNLEGCEQIDGHLIIEHAFTYE--------------QLKVLETVKIVSEYITIVQQN-------FYDLKFLKNLQIIEGRKLHNVRW-ALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCN-KRGCWGKEPEDCLECKTWKSV--GTCVEKCDTK-GFLRNQTS-----MKCERCSPECE----TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHF--PTQKNVCEKCHPTC-------YDNGCTGPDSNLGYGGCKQCKYA-----------VKYENDTIFCLQSS-----GMNNVCVENDLP---------------------NYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNN--TVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRC--------QRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKN-------------------VKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL-------GNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAF 1012
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 218.009 bits (554), Expect = 4.167e-57 Identity = 274/1169 (23.44%), Postives = 467/1169 (39.95%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGI-TNE----------------------NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSIL--GKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLS-SKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLV--HNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNG----ATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIII-NTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSN------QMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYN-DY-----CTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDG---TIESCHRCK-----SHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEG--CTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVC----VQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD---IESDFAPSSTK--LLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRII--------LVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
N ++ + + C V GN+ IT I NE +++F +++EEI G L ++ +++ IS L++I G+ ++ + +L + N + + +++ + +VI ++ + +NP M Y + I W +L Q +E H K + CH SC CWG+ CQ + R C S S+CF +CC C+GGC G C+ C + G C+E CP + + H + + N ++ N CV +CP + IEN+ CV C +G AT V E C C + CPK C + +L + L LE C G++II + + E Q K LE + + E ++ N L + +NL+II +N L+I Q DDL L L LK ++ G V I+ N +LCY + SI+ S + I N CE R C K C+ K GCWG C++C+ ++ C+ C + G+ N+ + M+C +C +C TC G G C YN D+ C CP H+ + N+C+ CH +C + CTGP +++G GC++C Y ++ ++ C+ SS G + ++ P N+ + E C C C CS +++ CK + + C+ C + ++ +++N ++C KCH EC + C C++CK ++ C S C N + C + ++ K G +V+ + + + W+C +R KLK + + I++ P+ ++ L+P +E Q + L G F + G + K V + V IKV +D + + L++ + L+II L +V Y L G+L FLK + + +L+ +Q+ASG Y++ + +++ D+ T N+ ++ + I+D GLSK+ IK GK+ I W E + ++ S V +
Sbjct: 59 NILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDE--VFHDN--ALYIHKN----DKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMA--KCHESCNDK-----CWGSGDNDCQRV---YRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRE-CEKCRSSSCPKICTVDG--------HLTNETLKNLEGCEQIDGHLIIEHAFTYE--------------QLKVLETVKIVSEYITIVQQN-------FYDLKFLKNLQIIEGRKLHNVRW-ALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCN-KRGCWGKEPEDCLECKTWKSV--GTCVEKCDTK-GFLRNQTS-----MKCERCSPECE----TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHF--PTQKNVCEKCHPTC-------YDNGCTGPDSNLGYGGCKQCKYA-----------VKYENDTIFCLQSS-----GMNNVCVENDLP---------------------NYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNN--TVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRC--------QRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKN-------------------VKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL-------GNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAF 1078
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 218.009 bits (554), Expect = 4.860e-57 Identity = 274/1169 (23.44%), Postives = 467/1169 (39.95%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGI-TNE----------------------NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSIL--GKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLS-SKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLV--HNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNG----ATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIII-NTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSN------QMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYN-DY-----CTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDG---TIESCHRCK-----SHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEG--CTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVC----VQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD---IESDFAPSSTK--LLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRII--------LVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
N ++ + + C V GN+ IT I NE +++F +++EEI G L ++ +++ IS L++I G+ ++ + +L + N + + +++ + +VI ++ + +NP M Y + I W +L Q +E H K + CH SC CWG+ CQ + R C S S+CF +CC C+GGC G C+ C + G C+E CP + + H + + N ++ N CV +CP + IEN+ CV C +G AT V E C C + CPK C + +L + L LE C G++II + + E Q K LE + + E ++ N L + +NL+II +N L+I Q DDL L L LK ++ G V I+ N +LCY + SI+ S + I N CE R C K C+ K GCWG C++C+ ++ C+ C + G+ N+ + M+C +C +C TC G G C YN D+ C CP H+ + N+C+ CH +C + CTGP +++G GC++C Y ++ ++ C+ SS G + ++ P N+ + E C C C CS +++ CK + + C+ C + ++ +++N ++C KCH EC + C C++CK ++ C S C N + C + ++ K G +V+ + + + W+C +R KLK + + I++ P+ ++ L+P +E Q + L G F + G + K V + V IKV +D + + L++ + L+II L +V Y L G+L FLK + + +L+ +Q+ASG Y++ + +++ D+ T N+ ++ + I+D GLSK+ IK GK+ I W E + ++ S V +
Sbjct: 54 NILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDE--VFHDN--ALYIHKN----DKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMA--KCHESCNDK-----CWGSGDNDCQRV---YRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRE-CEKCRSSSCPKICTVDG--------HLTNETLKNLEGCEQIDGHLIIEHAFTYE--------------QLKVLETVKIVSEYITIVQQN-------FYDLKFLKNLQIIEGRKLHNVRW-ALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCN-KRGCWGKEPEDCLECKTWKSV--GTCVEKCDTK-GFLRNQTS-----MKCERCSPECE----TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHF--PTQKNVCEKCHPTC-------YDNGCTGPDSNLGYGGCKQCKYA-----------VKYENDTIFCLQSS-----GMNNVCVENDLP---------------------NYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNN--TVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRC--------QRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKN-------------------VKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL-------GNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAF 1073
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Match: daf-2 (Insulin-like receptor Insulin-like receptor subunit alpha Insulin-like receptor subunit beta [Source:UniProtKB/Swiss-Prot;Acc:Q968Y9]) HSP 1 Score: 62.003 bits (149), Expect = 4.063e-9 Identity = 113/455 (24.84%), Postives = 179/455 (39.34%), Query Frame = 2
Query: 716 IEEITGFLFLFSN----SVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGK------------------RFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLN-TQCLICKHFNNQGACVEKCPRKLV---------------HNGVKHIKNRLEKFTFHNTCVDKCPDKYFI------ENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDL--VFLGLQELKEVRNGIVEIVNNPKLCY 1942
+ EITG L +F + I NL++I G + + ++L++ N E + L K VI + + +N + Y K I W ++ +V+ N++ + E G + +C+ G+ + CW N++ Q D + T ++ C G+ CH++CVGGC + T C CK+ ++G C+EKC L N V K K T C DKCPD Y I E KCV KC+ VC N+ I + RL C + GN+ T+ I G +G + I N+ I G L + S P++ +L FRNL I A++ ++L +++ +N +L +F +L R G V I NN LC+
Sbjct: 223 LREITGTLLVFETEGLVDLRKI-FPNLRVIGGRSLIQH----YALIIYRNPDLE-----IGLDKLSVIRNGGVRIIDNRKLCYTKT-IDWKHLITSSINDVVVD--NAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDR-----CHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKTVPIKAT-AGLCSDKCPDGYQINPDDHRECRKCVGKCEI----------------VCEI---------NHVIDTFPKAQAIRL--CNIIDGNL---TIEIRGKQDSGMASELKDI-------FANIHTITGYLLVRQSS--PFI-SLNMFRNLRRIEAKSL-FRNLYAITVFENPNLKKLFDSTTDLTLDR-GTVSIANNKMLCF 616
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654) HSP 1 Score: 345.125 bits (884), Expect = 1.384e-97 Identity = 301/1123 (26.80%), Postives = 495/1123 (44.08%), Query Frame = 2
Query: 644 NCTHVIGNVIITGITNENL--SFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEG--DIGNGW---PKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIY--NNGKDGKCE--ARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTI--ESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKI--------YLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQ-ELKPIQNSWYXXXXXXXXXXXXXXXXXWKCIC-------MSLNKRKRYDLKLKFSNGFSTVDIESDFAPSST-----KLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
NCT+V GN+ +T + NENL SFL++I E+TG++ + V+ + L+IIRG + E K++L V + + L +P + +L + +NN + + + I W+ I+ + + + +FT+ E CH SC CWG CQ + +C YG K +CCH C GGC GP C+ CK+F ++G C E+CP +N ++ N K+ + TCV +CP +N CV C E C+PC NG CPK C V+ NI NCTV GNI I + G D+ + P+ I + + LE + +KEI G L N+ P + L YFRNLE I L+I ++ L L ++ LK++ +G V I +N LCY ++ +I + ++ N + CE CS C+ + GCWG C+ C++F CI++C GY N ++ C CH +C TC G GAD C CV+ + +C +CP++ Y D +C+ CH +C CTGP + IG+ C CN L ++ + R C+ + C DGYF ++ P+ ++ + A+C CHPLC C++ + C +C ++R ++C C D Y + C +CH EC GCTG DCK C+ K+ Y+NS T F C S C R VN + + P P ++S A + +++ ++ ++ IC + K+K +K + S + PS+ KL + + + +L +G F + KG W + N V + V IK L + + +++FL++ I+ S + L+++ V + + L QL G L+++++ N + ++L W+ Q+A G Y++ + +++ D+ N+ +++P + I+D GL+KL ++ + K GK+ I W E ++ F+SKS V +
Sbjct: 128 NCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-----KMYTLEIPDLRDVLNGQVGFHNNYNLCHMRT-IQWSEIVSNG-----TDAYYNYDFTAPERECPKCHESCT-----HGCWGEGPKNCQKFSKLTCSPQCAGGRC--YGP-KPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGE-CVPC-NGPCPKTCPGVTVLHAGNID--------SFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYI-PLDPERLEVFSTVKEITGYL--NIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKS-SLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCN-EDGCWGAGTDQCLTCKNFNFN--GTCIADC----GYISNA--YKFDNRTCKICHPECR----TCNGAGADHCQ-ECVHVRDGQHCVSECPKNKYND---RGVCRECHATCDG---------CTGPKDTIGIGACTTCN---LAIINNDATVKR-------CLLKDDKCPDGYF---WEYVHPQ-----------------------EQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNS--TMFNCTSKCPLEMR-HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGEN--------------------VKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1127 HSP 2 Score: 51.2174 bits (121), Expect = 9.087e-6 Identity = 74/271 (27.31%), Postives = 106/271 (39.11%), Query Frame = 2
Query: 1544 NIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEIN-VGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVF--------LGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPK--YGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCP 2323
N ++ R + R NCT GN+ + W N + DL L N++E+ G + I+ V K + F L+IIR T L LS+ + +F L + +L++V NG V NN LC+ ++ I+ SN + Y N D R+C K CH +GCWG C Q K C C+ G Y + + CH C C GP C C N+ C E+CP
Sbjct: 114 NKEHHYRNLRDRYTNCTYVDGNLELT-----------WLPN----ENLDLSFLDNIREVTGYILISHVDVKK------VVFPKLQIIRGRT-----LFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIV-SNGTDAYYN-YDFTAPERECPK-CHESCTHGCWGEGPKNC------QKFSKLTCSPQCAG--GRCYGPKPREC-------CHLFCAGG---CTGPTQKDC-IACKNFFDEGVCKEECP 336
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653) HSP 1 Score: 343.969 bits (881), Expect = 1.709e-97 Identity = 301/1123 (26.80%), Postives = 495/1123 (44.08%), Query Frame = 2
Query: 644 NCTHVIGNVIITGITNENL--SFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEG--DIGNGW---PKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIY--NNGKDGKCE--ARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTI--ESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKI--------YLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQ-ELKPIQNSWYXXXXXXXXXXXXXXXXXWKCIC-------MSLNKRKRYDLKLKFSNGFSTVDIESDFAPSST-----KLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
NCT+V GN+ +T + NENL SFL++I E+TG++ + V+ + L+IIRG + E K++L V + + L +P + +L + +NN + + + I W+ I+ + + + +FT+ E CH SC CWG CQ + +C YG K +CCH C GGC GP C+ CK+F ++G C E+CP +N ++ N K+ + TCV +CP +N CV C E C+PC NG CPK C V+ NI NCTV GNI I + G D+ + P+ I + + LE + +KEI G L N+ P + L YFRNLE I L+I ++ L L ++ LK++ +G V I +N LCY ++ +I + ++ N + CE CS C+ + GCWG C+ C++F CI++C GY N ++ C CH +C TC G GAD C CV+ + +C +CP++ Y D +C+ CH +C CTGP + IG+ C CN L ++ + R C+ + C DGYF ++ P+ ++ + A+C CHPLC C++ + C +C ++R ++C C D Y + C +CH EC GCTG DCK C+ K+ Y+NS T F C S C R VN + + P P ++S A + +++ ++ ++ IC + K+K +K + S + PS+ KL + + + +L +G F + KG W + N V + V IK L + + +++FL++ I+ S + L+++ V + + L QL G L+++++ N + ++L W+ Q+A G Y++ + +++ D+ N+ +++P + I+D GL+KL ++ + K GK+ I W E ++ F+SKS V +
Sbjct: 79 NCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-----KMYTLEIPDLRDVLNGQVGFHNNYNLCHMRT-IQWSEIVSNG-----TDAYYNYDFTAPERECPKCHESCT-----HGCWGEGPKNCQKFSKLTCSPQCAGGRC--YGP-KPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGE-CVPC-NGPCPKTCPGVTVLHAGNID--------SFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYI-PLDPERLEVFSTVKEITGYL--NIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKS-SLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCN-EDGCWGAGTDQCLTCKNFNF--NGTCIADC----GYISNA--YKFDNRTCKICHPECR----TCNGAGADHCQ-ECVHVRDGQHCVSECPKNKYND---RGVCRECHATCDG---------CTGPKDTIGIGACTTCN---LAIINNDATVKR-------CLLKDDKCPDGYF---WEYVHPQ-----------------------EQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNS--TMFNCTSKCPLEMR-HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGEN--------------------VKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1078 HSP 2 Score: 51.2174 bits (121), Expect = 8.661e-6 Identity = 74/271 (27.31%), Postives = 106/271 (39.11%), Query Frame = 2
Query: 1544 NIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEIN-VGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVF--------LGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPK--YGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCP 2323
N ++ R + R NCT GN+ + W N + DL L N++E+ G + I+ V K + F L+IIR T L LS+ + +F L + +L++V NG V NN LC+ ++ I+ SN + Y N D R+C K CH +GCWG C Q K C C+ G Y + + CH C C GP C C N+ C E+CP
Sbjct: 65 NKEHHYRNLRDRYTNCTYVDGNLELT-----------WLPN----ENLDLSFLDNIREVTGYILISHVDVKK------VVFPKLQIIRGRT-----LFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIV-SNGTDAYYN-YDFTAPERECPK-CHESCTHGCWGEGPKNC------QKFSKLTCSPQCAG--GRCYGPKPREC-------CHLFCAGG---CTGPTQKDC-IACKNFFDEGVCKEECP 287
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: CG10702 (gene:FBgn0032752 transcript:FBtr0303241) HSP 1 Score: 75.485 bits (184), Expect = 3.033e-13 Identity = 112/504 (22.22%), Postives = 208/504 (41.27%), Query Frame = 2
Query: 536 ADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNE---NLSFLNS--IEEITGFLFLFSNSVESISL----KNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCY--GPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPC-PNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTG-LSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLC------YTDSLTNKSILHSNQMN 1990
A+S +H+ T I DIR++ N +L NCT V G V+IT IT E N S + + EIT F+ +F++ +++ +L +IRG + L + + L+ L+ PK I + + + + P + ++W+ L + N+ +K C H CW N Q I + +++ CHEEC+GGC C +C+ ++ G CV+ CP+ K++ ++ CV K Y I +CV C +G C+ C P+ C C + + + + N L C +++G+++I +I + + + + T+++E+ G +++ S+ L++L + RNLE + + N+H + L N+ ++ ++L+ + G+ NN KLC + +++T+ L S Q N
Sbjct: 22 AESKKEHECTSI------DIRNECKN-----MHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFM-IFTDVRGLVNITEMFPHLTVIRGR--------RLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSI-GRVNWD-------LLTLTRGENNIIMVNKNCSTPVCSGCSSSH-----CWSNHYCQRSINENVANPKANINA-------------CHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKD------KYVMENYQRCYTKAECVLK--HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPEWPGKAFTV--YNLADAENLRGCQIFNGSLVI---TIRNKVN----------ETQLYQSFTSMREVRGHVKVYRSSQ---LRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNN-KLCNRRMREFQNAVTHDRALDSLQTN 452
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: CG10702 (gene:FBgn0032752 transcript:FBtr0081176) HSP 1 Score: 75.485 bits (184), Expect = 3.033e-13 Identity = 112/504 (22.22%), Postives = 208/504 (41.27%), Query Frame = 2
Query: 536 ADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNE---NLSFLNS--IEEITGFLFLFSNSVESISL----KNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCY--GPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPC-PNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTG-LSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLC------YTDSLTNKSILHSNQMN 1990
A+S +H+ T I DIR++ N +L NCT V G V+IT IT E N S + + EIT F+ +F++ +++ +L +IRG + L + + L+ L+ PK I + + + + P + ++W+ L + N+ +K C H CW N Q I + +++ CHEEC+GGC C +C+ ++ G CV+ CP+ K++ ++ CV K Y I +CV C +G C+ C P+ C C + + + + N L C +++G+++I +I + + + + T+++E+ G +++ S+ L++L + RNLE + + N+H + L N+ ++ ++L+ + G+ NN KLC + +++T+ L S Q N
Sbjct: 22 AESKKEHECTSI------DIRNECKN-----MHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFM-IFTDVRGLVNITEMFPHLTVIRGR--------RLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSI-GRVNWD-------LLTLTRGENNIIMVNKNCSTPVCSGCSSSH-----CWSNHYCQRSINENVANPKANINA-------------CHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKD------KYVMENYQRCYTKAECVLK--HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPEWPGKAFTV--YNLADAENLRGCQIFNGSLVI---TIRNKVN----------ETQLYQSFTSMREVRGHVKVYRSSQ---LRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNN-KLCNRRMREFQNAVTHDRALDSLQTN 452
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Match: CG10702 (gene:FBgn0032752 transcript:FBtr0081174) HSP 1 Score: 75.485 bits (184), Expect = 3.033e-13 Identity = 112/504 (22.22%), Postives = 208/504 (41.27%), Query Frame = 2
Query: 536 ADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNE---NLSFLNS--IEEITGFLFLFSNSVESISL----KNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCY--GPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPC-PNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTG-LSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLC------YTDSLTNKSILHSNQMN 1990
A+S +H+ T I DIR++ N +L NCT V G V+IT IT E N S + + EIT F+ +F++ +++ +L +IRG + L + + L+ L+ PK I + + + + P + ++W+ L + N+ +K C H CW N Q I + +++ CHEEC+GGC C +C+ ++ G CV+ CP+ K++ ++ CV K Y I +CV C +G C+ C P+ C C + + + + N L C +++G+++I +I + + + + T+++E+ G +++ S+ L++L + RNLE + + N+H + L N+ ++ ++L+ + G+ NN KLC + +++T+ L S Q N
Sbjct: 22 AESKKEHECTSI------DIRNECKN-----MHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFM-IFTDVRGLVNITEMFPHLTVIRGR--------RLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSI-GRVNWD-------LLTLTRGENNIIMVNKNCSTPVCSGCSSSH-----CWSNHYCQRSINENVANPKANINA-------------CHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKD------KYVMENYQRCYTKAECVLK--HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPEWPGKAFTV--YNLADAENLRGCQIFNGSLVI---TIRNKVN----------ETQLYQSFTSMREVRGHVKVYRSSQ---LRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNN-KLCNRRMREFQNAVTHDRALDSLQTN 452
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1]) HSP 1 Score: 246.514 bits (628), Expect = 4.512e-69 Identity = 196/617 (31.77%), Postives = 299/617 (48.46%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGITNE-NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIG--ENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNI--YNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTK 2389
++ +V + +NCT V+ N+ IT IT + +LSFL SI+E+ G++ + N+V I L+NL+IIRG + + E KF+L V+ N E +K L L IL+ + +N L I W IL IV HN S K G C P CWG +CQ + + + S +C G I+ CC+E C GC GP T CL CK F ++G C + CPR ++++ H N K++F TC+ CP Y + ++ CV C G TY V+E C C G+CPK C + N+ +N + ENCT GN+ I + + GD N G+ L L+ +KEI G L I + ++ +++L F NLE+IR T + ++ + + LG++ L+E+ +G V IV N LCY+ K + S Q ++ N C + C+++C GCWGP C C H+ + C+++C+ G E ++T C +C +CL N TC GPG D+CT C NYK +C +CPQ G+ T +++C+ CH++CT+
Sbjct: 43 DHYQVLLRMYRNCTVVLENLEITHITEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHSLY---EDKFALAVLVNYNNSIEQGVKELPLTSLTEILKGGVR-FNMNNHLCNVGTIEWADILNMKSLPTIVS-HNIS--YGKNCG------KCDPSCFNGSCWGTGPDKCQRMTKVICAE-QCSGRC--KGPRPID-CCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPG-TYEVDEGGVRKCKRC-EGLCPKVCNGLGMGPLANVLSINATNIDSFENCTKISGNVAILSTTFRGDPHT----NTSGLDPAKLSVLSTVKEITGYLMIQLWPES--MQSLSAFENLEVIRGRTKTQGTYS-FAVTKT-AITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQQSVKMIENMDAATCANQNSTCNEMCTAD-GCWGPGPTMCFGCEHY--SRGKHCVASCNLLNGEPREYEVNKT----CMECDPECLLMNETQTCNGPGPDKCTV-CANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQ 624
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1]) HSP 1 Score: 248.825 bits (634), Expect = 8.653e-69 Identity = 206/666 (30.93%), Postives = 318/666 (47.75%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGITNE-NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIG--ENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNI--YNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCR--KCNYVQLLTNGSEGFISRFTVHSL 2530
++ +V + +NCT V+ N+ IT IT + +LSFL SI+E+ G++ + N+V I L+NL+IIRG + + E KF+L V+ N E +K L L IL+ + +N L I W IL IV HN S K G C P CWG +CQ + + + S +C G I+ CC+E C GC GP T CL CK F ++G C + CPR ++++ H N K++F TC+ CP Y + ++ CV C G TY V+E C C G+CPK C + N+ +N + ENCT GN+ I + + GD N G+ L L+ +KEI G L I + ++ +++L F NLE+IR T + ++ + + LG++ L+E+ +G V IV N LCY+ K + S Q ++ N C + C+++C GCWGP C C H+ + C+++C+ G E ++T C +C +CL N TC GPG D+CT C NYK +C +CPQ G+ T +++C+ CH++CT + CTGP + C+ K + + ++ G G + F + +L
Sbjct: 43 DHYQVLLRMYRNCTVVLENLEITHITEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHSLY---EDKFALAVLVNYNNSIEQGVKELPLTSLTEILKGGVR-FNMNNHLCNVGTIEWADILNMKSLPTIVS-HNIS--YGKNCG------KCDPSCFNGSCWGTGPDKCQRMTKVICAE-QCSGRC--KGPRPID-CCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPG-TYEVDEGGVRKCKRC-EGLCPKVCNGLGMGPLANVLSINATNIDSFENCTKISGNVAILSTTFRGDPHT----NTSGLDPAKLSVLSTVKEITGYLMIQLWPES--MQSLSAFENLEVIRGRTKTQGTYS-FAVTKT-AITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQQSVKMIENMDAATCANQNSTCNEMCTAD-GCWGPGPTMCFGCEHY--SRGKHCVASCNLLNGEPREYEVNKT----CMECDPECLLMNETQTCNGPGPDKCTV-CANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCT--------QGCTGP----DLKDCKDFKSSGLPMIAAGVVGGLLAFVILAL 661
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1]) HSP 1 Score: 252.292 bits (643), Expect = 7.941e-68 Identity = 207/667 (31.03%), Postives = 319/667 (47.83%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGITNE-NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIG--ENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNI--YNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCR--KCNYVQLLTNGSEGFISRFTVHSL 2530
++ +V + +NCT V+ N+ IT IT + +LSFL SI+E+ G++ + N+V I L+NL+IIRG + + E KF+L V+ N E +K L L IL+ + +N L I W IL IV HN S K G C P CWG +CQ + + + C S +C G I+ CC+E C GC GP T CL CK F ++G C + CPR ++++ H N K++F TC+ CP Y + ++ CV C G TY V+E C C G+CPK C + N+ +N + ENCT GN+ I + + GD N G+ L L+ +KEI G L I + ++ +++L F NLE+IR T + ++ + + LG++ L+E+ +G V IV N LCY+ K + S Q ++ N C + C+++C GCWGP C C H+ + C+++C+ G E ++T C +C +CL N TC GPG D+CT C NYK +C +CPQ G+ T +++C+ CH++CT+ CTGP + C+ K + + ++ G G + F + +L
Sbjct: 43 DHYQVLLRMYRNCTVVLENLEITHITEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHSLY---EDKFALAVLVNYNNSIEQGVKELPLTSLTEILKGGVR-FNMNNHLCNVGTIEWADILNMKSLPTIVS-HNIS--YGKNCG------KCDPSCFNGSCWGTGPDKCQRMTKVICAEQC--SGRC--KGPRPID-CCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPG-TYEVDEGGVRKCKRC-EGLCPKVCNGLGMGPLANVLSINATNIDSFENCTKISGNVAILSTTFRGDPHT----NTSGLDPAKLSVLSTVKEITGYLMIQLWPES--MQSLSAFENLEVIRGRTKTQGTYS-FAVTKT-AITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQQSVKMIENMDAATCANQNSTCNEMCTAD-GCWGPGPTMCFGCEHY--SRGKHCVASCNLLNGEPREYEVNKT----CMECDPECLLMNETQTCNGPGPDKCTV-CANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQ--------GCTGP----DLKDCKDFKSSGLPMIAAGVVGGLLAFVILAL 661 HSP 2 Score: 88.5817 bits (218), Expect = 5.118e-17 Identity = 54/227 (23.79%), Postives = 104/227 (45.81%), Query Frame = 2
Query: 3218 SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
S AP+ L + E + +L G F + KG W + N V + V IKVL E + NK+ + + ++ S + P R++ + + + +L QL G L++++++N + +L W Q+A G Y++ +++ D+ N+ +++P + I+D GL+KL N + GK+ I W E+ + ++ +S V +Y
Sbjct: 694 SGEAPNQALLRILKETEFKKIKVLGSGAFGTVHKGLWVPEGEN--------------------VKIPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLTSTVQLITQLMPYGCLLDYVRENKDRIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESIQHRTYTHQSDVWSYG 900 HSP 3 Score: 51.6026 bits (122), Expect = 8.688e-6 Identity = 29/93 (31.18%), Postives = 41/93 (44.09%), Query Frame = 2
Query: 2690 EYQFGAICLPCHPLC------SQCSDGTIESCHRCKSHRRGKECVHNCY-----EDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCK 2935
EY+ C+ C P C C+ + C C +++ G CVH C E D + ++ +C CHE C +GCTG DCK K
Sbjct: 546 EYEVNKTCMECDPECLLMNETQTCNGPGPDKCTVCANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQGCTGPDLKDCKDFK 638
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 248.44 bits (633), Expect = 3.061e-66 Identity = 201/634 (31.70%), Postives = 301/634 (47.48%), Query Frame = 2
Query: 620 KVTANLNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNG----VKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC-KNGATYAVNET--CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLT---NLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQMNIYNNGKDGKCEARKCS---KLCHP---KYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSS---NITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTGP 2428
K +NC V+GN+ IT I N NLSFL SI E+TG++ + N + + L+NL+IIRG + E ++SL + N G L+ L L IL + V N L + IHW+ I+ + +V P N+S T + CH SC G+ CWG+ QCQ + V + C +CF + CCH EC GGC+GP +T C C +FN+ GACV +CP+ V+N ++H N K+T+ CV KCP + +++ CV C N N+T C+PC + +CPK C Q ++ + + NCT +GN+I I+GD+ +GI+ D ++L ++EI G L NV S + L F NL I + + L I + + L Q L+E+ G V + NN +LC+ ++ S+ S Q + N + E R+CS K+C P + GCWGP C+ C++F + C+ +C+ +Y + C +C +QC + +TC+GPG D C C++ K C EKCP G S T+N C CH +CT+ CTGP
Sbjct: 20 KTLRKFYENCEVVMGNLEITSIERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLY---EGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQN-KFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTCRR-----CHRSCN---GR--CWGHQEDQCQSLTKTVCAEQC--DGRCF---GPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPN--AKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTD-ICPKVCDGIGTGSLQMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDM-------FHGIRALDPDRLNVFRTVREITGFL--NVQSWPENMTDLGVFSNLATIGGRSLYSG--ISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNR----EPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYF--SRGKTCVKSCN----LYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQ--------GCTGP 601 HSP 2 Score: 98.9821 bits (245), Expect = 3.466e-20 Identity = 93/414 (22.46%), Postives = 164/414 (39.61%), Query Frame = 2
Query: 2690 EYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E+ G++C+ C C + + + + C +C + G CV C D NS + + C CH C +GCTG DC V I +T + G F I + + V V + K I +K+ L+ S AP+ +L + E + IL G F ++ KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L +T + GK+ I W E + + F+ +S V +Y
Sbjct: 518 EFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKC-PDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDC-----VGIL---DRTPLIAAGLIGGLFVIVIIALGVAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGMVYKGIWVPEG--------------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSY 869
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 246.128 bits (627), Expect = 9.466e-66 Identity = 196/618 (31.72%), Postives = 292/618 (47.25%), Query Frame = 2
Query: 620 KVTANLNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNG----VKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC-KNGATYAVNET--CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQMNIYNNGKDGKCEARKCS---KLCHP---KYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSS---NITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
K +NC V+GN+ IT I N NLSFL SI E+TG++ + N + + L+NL+IIRG + E ++SL + N G L+ L L IL + V N L + IHW+ I+ + +V P N+S T K CH SC CWG+ QCQ + V + C +CF + CCH EC GGC+GP +T C C +FN+ GACV +CP+ V+N ++H N K+T+ CV KCP + +++ CV C N N+T C+PC + +CPK C Q ++ + + NCT +GN+I I+GD+ +G I + L ++EI G L NV S + L F NL I + + L I + + L Q L+E+ G V + NN +LC+ ++ S+ S Q + N + E R+CS K+C P + GCWGP C+ C++F + C+ +C+ +Y + C +C +QC + +TC+GPG D C C++ K C EKCP G S T+N C CH +CT+
Sbjct: 20 KTLRKFYENCEVVMGNLEITSIERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLY---EGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQN-KFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTCKR-----CHRSCNGR-----CWGHQEDQCQSLTKTVCAEQC--DGRCF---GPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPN--AKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTD-ICPKVCDGIGTGSLQMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHG----IRALDPDRLNVFRTVREITGFL--NVQSWPENMTDLGVFSNLATIGGRSLYSG--ISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNR----EPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYF--SRGKTCVKSCN----LYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQ 596 HSP 2 Score: 92.4337 bits (228), Expect = 3.508e-18 Identity = 91/424 (21.46%), Postives = 176/424 (41.51%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLN-----KRKRYDLKLKFSNGFSTVDIE----SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E+ G++C+ C C + + + + C +C + G CV C D NS + + C CH C +G + C+ + ++ + C S+ + F + C P+ IQ+ +++ +G ++ + ++L +RK K T +E S AP+ +L + E + IL G F ++ KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L +T + GK+ I W E + + F+ +S V +Y
Sbjct: 517 REFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKC-PDGLQGANSFIFKYAETNNECHPCHPNCTQGSVACNRFRCRTRILYRTSCDNPMQSYNC-SLDRNMFDAMFLNVTYCTGPR----IQDC-VGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGMVYKGIWVPEG--------------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSY 913
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 226.098 bits (575), Expect = 2.874e-59 Identity = 190/605 (31.40%), Postives = 273/605 (45.12%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQ-MNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC---LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCT 2386
+NC V+GN+ IT I NLSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + + N L + + IHW I+ + N T + C SC MG+ CWG S CQ + V C YG + CCH EC GGC GP +T C C FN+ G+CV +CP+ ++N + +N K+T+ CV+KCP + +++ CV C + + C PC G+CPK C + Q ++ + + NCT +GN+ I+GD + NI ++ + L ++EI G L N+ S + L F NL I + L I + L L Q LKE+ G V I +N LCY ++ S+ SNQ I N K C A C LC GCWGP C+ CR+F + C+ +C+ Y E+ + + C C +QC S +TCYGPG D CT C N+K C EKCP+ G S C CH +CT
Sbjct: 36 ENCEVVMGNLEITSIEPGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLY---EDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQN-KFLCYADTIHWQDIV------------RTPNATLVPMSSGRCPKSC---MGR--CWGPSDQHCQRLTKTV---CAEQCDGRCYGSY-VSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPC-AGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYH----NIAALEPQKLNIFFTVREITGFL--NIQSWPRNMTDLSVFSNLVNIGGRVLYSG--ISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCS-NAGCWGPGANQCLSCRYF--SRGKSCVRSCN-----LYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCT 597 HSP 2 Score: 102.834 bits (255), Expect = 2.671e-21 Identity = 90/416 (21.63%), Postives = 167/416 (40.14%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYE-----DDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
+ E+ G++C+ C C + D + + C +C + + G CV C E + +I K ++ + C CH C +GC T +DC + + ++T S+ G F I + + V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 518 SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFK-YADEDKECHPCHPNCTDGCNNPTSHDCLWNDPLTL-PQHARTPLIAASVIGGLFIIVIMALTFAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 878
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 226.098 bits (575), Expect = 2.908e-59 Identity = 190/605 (31.40%), Postives = 273/605 (45.12%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQ-MNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC---LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCT 2386
+NC V+GN+ IT I NLSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + + N L + + IHW I+ + N T + C SC MG+ CWG S CQ + V C YG + CCH EC GGC GP +T C C FN+ G+CV +CP+ ++N + +N K+T+ CV+KCP + +++ CV C + + C PC G+CPK C + Q ++ + + NCT +GN+ I+GD + NI ++ + L ++EI G L N+ S + L F NL I + L I + L L Q LKE+ G V I +N LCY ++ S+ SNQ I N K C A C LC GCWGP C+ CR+F + C+ +C+ Y E+ + + C C +QC S +TCYGPG D CT C N+K C EKCP+ G S C CH +CT
Sbjct: 31 ENCEVVMGNLEITSIEPGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLY---EDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQN-KFLCYADTIHWQDIV------------RTPNATLVPMSSGRCPKSC---MGR--CWGPSDQHCQRLTKTV---CAEQCDGRCYGSY-VSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPC-AGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYH----NIAALEPQKLNIFFTVREITGFL--NIQSWPRNMTDLSVFSNLVNIGGRVLYSG--ISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCS-NAGCWGPGANQCLSCRYF--SRGKSCVRSCN-----LYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCT 592 HSP 2 Score: 102.834 bits (255), Expect = 2.666e-21 Identity = 90/416 (21.63%), Postives = 167/416 (40.14%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYE-----DDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
+ E+ G++C+ C C + D + + C +C + + G CV C E + +I K ++ + C CH C +GC T +DC + + ++T S+ G F I + + V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 513 SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFK-YADEDKECHPCHPNCTDGCNNPTSHDCLWNDPLTL-PQHARTPLIAASVIGGLFIIVIMALTFAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 873
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 226.098 bits (575), Expect = 3.085e-59 Identity = 190/605 (31.40%), Postives = 273/605 (45.12%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQ-MNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC---LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCT 2386
+NC V+GN+ IT I NLSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + + N L + + IHW I+ + N T + C SC MG+ CWG S CQ + V C YG + CCH EC GGC GP +T C C FN+ G+CV +CP+ ++N + +N K+T+ CV+KCP + +++ CV C + + C PC G+CPK C + Q ++ + + NCT +GN+ I+GD + NI ++ + L ++EI G L N+ S + L F NL I + L I + L L Q LKE+ G V I +N LCY ++ S+ SNQ I N K C E C LC GCWGP C+ CR+F + C+ +C+ Y E+ + + C C +QC S +TCYGPG D CT C N+K C EKCP+ G S C CH +CT
Sbjct: 62 ENCEVVMGNLEITSIEPGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLY---EDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQN-KFLCYADTIHWQDIV------------RTPNATLVPMSSGRCPKSC---MGR--CWGPSDQHCQRLTKTV---CAEQCDGRCYGSY-VSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPC-AGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYH----NIAALEPQKLNIFFTVREITGFL--NIQSWPRNMTDLSVFSNLVNIGGRVLYSG--ISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCS-NAGCWGPGANQCLSCRYF--SRGKSCVRSCN-----LYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCT 623 HSP 2 Score: 102.834 bits (255), Expect = 3.310e-21 Identity = 90/416 (21.63%), Postives = 167/416 (40.14%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYE-----DDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
+ E+ G++C+ C C + D + + C +C + + G CV C E + +I K ++ + C CH C +GC T +DC + + ++T S+ G F I + + V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 544 SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFK-YADEDKECHPCHPNCTDGCNNPTSHDCLWNDPLTL-PQHARTPLIAASVIGGLFIIVIMALTFAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 904
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 226.098 bits (575), Expect = 3.138e-59 Identity = 190/605 (31.40%), Postives = 273/605 (45.12%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQ-MNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC---LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCT 2386
+NC V+GN+ IT I NLSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + + N L + + IHW I+ + N T + C SC MG+ CWG S CQ + V C YG + CCH EC GGC GP +T C C FN+ G+CV +CP+ ++N + +N K+T+ CV+KCP + +++ CV C + + C PC G+CPK C + Q ++ + + NCT +GN+ I+GD + NI ++ + L ++EI G L N+ S + L F NL I + L I + L L Q LKE+ G V I +N LCY ++ S+ SNQ I N K C A C LC GCWGP C+ CR+F + C+ +C+ Y E+ + + C C +QC S +TCYGPG D CT C N+K C EKCP+ G S C CH +CT
Sbjct: 36 ENCEVVMGNLEITSIEPGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLY---EDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQN-KFLCYADTIHWQDIV------------RTPNATLVPMSSGRCPKSC---MGR--CWGPSDQHCQRLTKTV---CAEQCDGRCYGSY-VSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPC-AGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYH----NIAALEPQKLNIFFTVREITGFL--NIQSWPRNMTDLSVFSNLVNIGGRVLYSG--ISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCS-NAGCWGPGANQCLSCRYF--SRGKSCVRSCN-----LYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCT 597 HSP 2 Score: 102.834 bits (255), Expect = 2.736e-21 Identity = 90/416 (21.63%), Postives = 167/416 (40.14%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYE-----DDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
+ E+ G++C+ C C + D + + C +C + + G CV C E + +I K ++ + C CH C +GC T +DC + + ++T S+ G F I + + V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 518 SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFK-YADEDKECHPCHPNCTDGCNNPTSHDCLWNDPLTL-PQHARTPLIAASVIGGLFIIVIMALTFAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 878
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 226.098 bits (575), Expect = 3.240e-59 Identity = 190/605 (31.40%), Postives = 273/605 (45.12%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQ-MNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC---LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCT 2386
+NC V+GN+ IT I NLSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + + N L + + IHW I+ + N T + C SC MG+ CWG S CQ + V C YG + CCH EC GGC GP +T C C FN+ G+CV +CP+ ++N + +N K+T+ CV+KCP + +++ CV C + + C PC G+CPK C + Q ++ + + NCT +GN+ I+GD + NI ++ + L ++EI G L N+ S + L F NL I + L I + L L Q LKE+ G V I +N LCY ++ S+ SNQ I N K C A C LC GCWGP C+ CR+F + C+ +C+ Y E+ + + C C +QC S +TCYGPG D CT C N+K C EKCP+ G S C CH +CT
Sbjct: 35 ENCEVVMGNLEITSIEPGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLY---EDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQN-KFLCYADTIHWQDIV------------RTPNATLVPMSSGRCPKSC---MGR--CWGPSDQHCQRLTKTV---CAEQCDGRCYGSY-VSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPC-AGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYH----NIAALEPQKLNIFFTVREITGFL--NIQSWPRNMTDLSVFSNLVNIGGRVLYSG--ISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMVCDPLCS-NAGCWGPGANQCLSCRYF--SRGKSCVRSCN-----LYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCT 596 HSP 2 Score: 102.834 bits (255), Expect = 3.027e-21 Identity = 90/416 (21.63%), Postives = 167/416 (40.14%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYE-----DDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
+ E+ G++C+ C C + D + + C +C + + G CV C E + +I K ++ + C CH C +GC T +DC + + ++T S+ G F I + + V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 517 SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFK-YADEDKECHPCHPNCTDGCNNPTSHDCLWNDPLTL-PQHARTPLIAASVIGGLFIIVIMALTFAVYIRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 877
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 230.335 bits (586), Expect = 9.699e-63 Identity = 194/622 (31.19%), Postives = 279/622 (44.86%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKH--QFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLS--INQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTG 2425
+NC V+GN+ IT I N +LSFL SI E+TG++ + N + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + + IHW I+ + +V + SS G CH SC CWG + CQ + R C YG + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV KCP + +++ CV C + + V E C PC + +CPK C + Q ++ + + NCT +GN+I I GD N I I + L ++EI G L N+ S P + F NL I +GLS I + + L Q LKE+ G + I +N LCY ++ ++ + ++ I +N + C E C+ LC GCWGP C+ CR F + +CI +C+ G F EN C +C +QC +TC+GPG D CT C ++K C EKCP G S C CH +CT+ + S C G
Sbjct: 54 ENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLY---EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNK-FLCYADTIHWQDIVRNPWPSNMTLVSTNGSS-------GCGRCHKSCTGR-----CWGPTENHCQTL---TRTVCAEQCDGRCYGPY-VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPS-SKMEVEENGIKMCKPCTD-ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA----IDAIDPEKLNVFRTVREITGFL--NIQSWPPNMTDFSVFSNLVTIGGRVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSND-GCWGPGPDQCLSCRRF--SRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCIGSSIEDCIG 635
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411]) HSP 1 Score: 234.958 bits (598), Expect = 4.841e-62 Identity = 189/650 (29.08%), Postives = 291/650 (44.77%), Query Frame = 2
Query: 524 SFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGN--VIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVV--SNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGV--KHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS---NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
S R + Q C L + +N + L + C V+GN +++TG N +LSFL I E+TG++ + N + L NL+++RG +Y + KF++ V+ N + L+ L + IL + + N + + + I W I+ + EIV +N N CH C K CWG CQI+ + + + +CF QCCH+EC GGC GP +T C C+HFN+ GACV +CP LV+N + + N K+ + CV CP + ++ CV C KNG + C PC G+CPK C Y Q ++ + NCT GN+ I G G+ W K I + + L ++EI G L N+ S P + F NL I + N+ + L I +N ++ LG + LKE+ G V I N +LCY SL +L +++I N G+C E + C LC GCWGP C+ CR++ + + +C+++C+ + HE C CH +C + TC G G+D C C +++ +C CP G N C+ CH++CT+
Sbjct: 15 SLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTG-HNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQ--VY-DGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHM-DTIDWRDIV-RVPDAEIVVKNNGGNCPP-------CHEVC-----KGRCWGPGPEDCQILTKTICAP-QCNGRCF---GPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGL-----KMCEPC-RGLCPKACEGTGSGSRY--QTVDSSNIDGFVNCTKILGNL---DFLITGLNGDPWHK-IPALDPEKLNVFRTVREITGYL--NIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFS-LLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCS-SGGCWGPGPGQCLSCRNY--SREGVCVTHCN----VLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACAR-CAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQ 619 HSP 2 Score: 60.077 bits (144), Expect = 2.365e-8 Identity = 44/206 (21.36%), Postives = 91/206 (44.17%), Query Frame = 2
Query: 3284 ILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+L G F + KG W IP+ E + + V IKV+ + S + + + S D +R++ + + +L Q GSL++ ++Q+ + +L W Q+A G Y++ +++ D+ N+ ++SP ++ ++D G++ L ++ E K I W E+ + ++ +S V +Y
Sbjct: 712 VLGSGVFGTVHKGIW---------------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYG 896
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 233.032 bits (593), Expect = 1.518e-61 Identity = 196/626 (31.31%), Postives = 282/626 (45.05%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKH--QFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLS--INQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTGPGNH 2437
+NC V+GN+ IT I N +LSFL SI E+TG++ + N + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + + IHW I+ + +V + SS G CH SC G+ CWG + CQ + R C YG + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV KCP + +++ CV C + + V E C PC + +CPK C + Q ++ + + NCT +GN+I I GD N I I + L ++EI G L N+ S P + F NL I +GLS I + + L Q LKE+ G + I +N LCY ++ ++ + ++ I +N + C A C+ LC GCWGP C+ CR F + +CI +C+ G F EN C +C +QC +TC+GPG D CT C ++K C EKCP G S C CH +CT+ C GP +H
Sbjct: 54 ENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLY---EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQN-KFLCYADTIHWQDIVRNPWPSNMTLVSTNGSS-------GCGRCHKSC---TGR--CWGPTENHCQTL---TRTVCAEQCDGRCYGPY-VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPS-SKMEVEENGIKMCKPCTD-ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA----IDAIDPEKLNVFRTVREITGFL--NIQSWPPNMTDFSVFSNLVTIGGRVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCS-NDGCWGPGPDQCLSCRRF--SRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQ--------GCNGPTSH 631 HSP 2 Score: 104.76 bits (260), Expect = 5.492e-22 Identity = 90/426 (21.13%), Postives = 162/426 (38.03%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDC-----------KQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E++ G+IC+ C C + DG + ++C +C + G CV C D NS ++ + C CH C +GC G T +DC Q R + F I F ++V + + +K+ L+ S AP+ +L + E + +L G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 544 REFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC-PDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSI------------------------------------------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 906
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 232.646 bits (592), Expect = 1.788e-61 Identity = 196/626 (31.31%), Postives = 282/626 (45.05%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKH--QFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLS--INQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTGPGNH 2437
+NC V+GN+ IT I N +LSFL SI E+TG++ + N + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + + IHW I+ + +V + SS G CH SC G+ CWG + CQ + R C YG + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV KCP + +++ CV C + + V E C PC + +CPK C + Q ++ + + NCT +GN+I I GD N I I + L ++EI G L N+ S P + F NL I +GLS I + + L Q LKE+ G + I +N LCY ++ ++ + ++ I +N + C A C+ LC GCWGP C+ CR F + +CI +C+ G F EN C +C +QC +TC+GPG D CT C ++K C EKCP G S C CH +CT+ C GP +H
Sbjct: 54 ENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLY---EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQN-KFLCYADTIHWQDIVRNPWPSNMTLVSTNGSS-------GCGRCHKSC---TGR--CWGPTENHCQTL---TRTVCAEQCDGRCYGPY-VSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPS-SKMEVEENGIKMCKPCTD-ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA----IDAIDPEKLNVFRTVREITGFL--NIQSWPPNMTDFSVFSNLVTIGGRVL----YSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCS-NDGCWGPGPDQCLSCRRF--SRGKICIESCNLYDGEFREFENGSI----CVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQ--------GCNGPTSH 631 HSP 2 Score: 104.76 bits (260), Expect = 5.410e-22 Identity = 90/426 (21.13%), Postives = 162/426 (38.03%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDC-----------KQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E++ G+IC+ C C + DG + ++C +C + G CV C D NS ++ + C CH C +GC G T +DC Q R + F I F ++V + + +K+ L+ S AP+ +L + E + +L G F + KG W + E V + V IK+L+E + N +F+ + I+ S D P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E + + F+ +S V +Y
Sbjct: 544 REFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKC-PDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSI------------------------------------------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 906
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]) HSP 1 Score: 216.853 bits (551), Expect = 8.492e-59 Identity = 186/623 (29.86%), Postives = 283/623 (45.43%), Query Frame = 2
Query: 644 NCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNI-IGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSS----CQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIK--NRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS--NQMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCL--SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPG 2431
NC V+GN+ IT + N +LSFL +I+E+ G++ + N+VE I L+NL+IIRG + E ++L ++SN L+ L + Q IL + NNP +L + I W I+ + F S DL H S C P CWG CQ + + + S +C CCH +C GC GP + CL+C+ F ++ C + CP +++N + N K++F TCV KCP Y + ++ CV C Y V E C C +G C K C + + + +N + + CT G++ I ++ +GD P + ++LE L +KEI G L I W L F NLEIIR T + + + N + LGL+ LKE+ +G V I N LCY +++ K + + + I NN + C+A C+ LC + GCWGP CV C++ ++ C+ C+ G + +C +CH +CL + NITC G G D C C +Y +C + CP G+ +T +N+C CH +CT C GPG
Sbjct: 57 NCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALY---ENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNP-ILCNMDTIQWRDIV-------------QNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQ-QCSHRCRGRSP---SDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRAC-GPDYYEVEEDGIRKCKKC-DGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPP----LDPRELEILKTVKEITGFLLIQAWPDN-WTD-LHAFENLEIIRGRTKQHGQFSLAVVGLN--ITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSE-GCWGPEPRDCVSCQN--VSRGRECVEKCNILEG----EPREFVENSECIQCHPECLPQAMNITCTGRGPDNC-IQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCT--------YGCAGPG 632
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3) HSP 1 Score: 331.643 bits (849), Expect = 3.685e-92 Identity = 299/1123 (26.63%), Postives = 492/1123 (43.81%), Query Frame = 2
Query: 644 NCTHVIGNVIITGITNENL--SFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEG--DIGNGW---PKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIY--NNGKDGKCE--ARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSD-GTIES-CHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKI--------YLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQ-ELKPIQNSWYXXXXXXXXXXXXXXXXXWKCIC-------MSLNKRKRYDLKLKFSNGFSTVDIESDFAPSST-----KLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
NCT+V GN+ +T + NENL SFL++I E+TG++ + V+ + L+IIRG + E K++L V + + L +P + +L + +NN + + + I W+ I+ + + + +FT+ E CH SC CWG CQ + +C YG K +CCH C GGC GP C+ CK+F ++ E+CP +N ++ N K+ + TCV +CP +N CV C E C+PC NG CPK C V+ NI NCTV GNI I + G D+ + P+ I + + E + +KEI G L N+ P + L YFRNLE I L+I ++ L L ++ LK++ +G V I +N LCY ++ +I + ++ N + CE CS C+ + GCWG C+ C++F CI++C GY N ++ C CH +C TC G GAD C CV+ + +C +CP++ Y D +C+ CH +C CTGP + IG+ C CN L ++ + R C+ + C DGYF ++ P+ ++ + A+C CHPLC C++ G E C +C ++R ++C C D Y + C + H EC GCTG DCK C+ K+ Y+NS T F C S C R VN + + P P ++S A + +++ ++ ++ IC + K+K +K + S + PS+ KL + + + +L +G F + KG W + N V + V IK L + + +++FL++ I+ S + L+++ V + + L QL G L+++++ N + ++L W+ Q+A G Y++ + +++ D+ N+ +++P + I+D GL+KL ++ + K GK+ I W E ++ F+SKS V +
Sbjct: 128 NCTYVDGNLKLTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-----KMYTLEIPDLRDVLNGQVGFHNNYNLCHMRT-IQWSEIVSNG-----TDAYYNYDFTAPERECPKCHESCT-----HGCWGEGPKNCQKFSKLTCSPQCAGGRC--YGP-KPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGE-CVPC-NGPCPKTCPGVTVLHAGNID--------SFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYI-PLDPERREVFSTVKEITGYL--NIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKS-SLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCN-EDGCWGAGTDQCLTCKNFNFN--GTCIADC----GYISNA--YKFDNRTCKICHPECR----TCNGAGADHCQ-ECVHVRDGQHCVSECPKNKYND---RGVCRECHATCDG---------CTGPKDTIGIGACTTCN---LAIINNDATVKR-------CLLKDDKCPDGYF---WEYVHPQ-----------------------EQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRE----CFQRHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNS--TMFNCTSKCPLEMR-HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGEN--------------------VKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1127
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1) HSP 1 Score: 306.22 bits (783), Expect = 3.524e-84 Identity = 273/1026 (26.61%), Postives = 432/1026 (42.11%), Query Frame = 2
Query: 926 VYNNPGMLYFKNNIHWNSIL-GKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEG--------DIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMN--IYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIES--CHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYL----NSSKTKFFCNSICGDNF--RIF-VNSEMVC------VQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSS-----TKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+YNN + + + I+W I+ G V NFTS E C SC+ + CWG CQ + +CF +CCH C GGC GP + C+ CK+F + G C ++CP +N + N K+ + TCV +CP+ +N CV C A+N C+PC +G CPK C + V + NI ++CT+ G+I I S +G G + K + LE + LKEI G L I K K L YFRNLE+I T ++ L + + LV GL LK++ +G + I+ N LCY S+ I S++ + NN + +C + C + C + GCWGP C+ C++F + N C+ +C+ PG + Q E C CH +C S C GP D C C + + +C +CP Y D + +CK+CH +C C GP N+IG NGC C+ L + EG C+ +C DGY+ ++ SP +++ A+C CH C +C+ C C ++RG++C C D + ++A LC+ C EC GC G C +C+ KIY+ + + T F C C + +IF +SE C + EL+P + +V + W+ + K + +K + + +D P+ KL I E + IL G F + KG W + N V + V IKVL + + +K+FL + I+ S + P L+++ V + + L QL G L++F+++ + ++L W Q+A G Y++ +++ D+ N+ +++P + I+D GL+KL + K GK+ I W E + F+ KS V +
Sbjct: 1 MYNNYNLCHIRT-INWEEIITGPSAMYSYV-----YNFTSPERACTPCDKSCE-----QGCWGEGPENCQKYSKTNCSPQCWQGRCF---GPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCPPKKK-ALNGECVPC-DGPCPKTCKGVEKVHSGNID--------SFKDCTIIEGSITILDQSFQGFQHVYRNFSFGKRYEK----MHPDKLEVFSTLKEITGFLNIQGDHKD--FKNLSYFRNLEVIGGRTL-TEYFASLYVVKT-SLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDE-GCWGPGPAQCLSCKNFILG--NDCLQDCTA-PGIY------QADEKTCKVCHEECDGS---CIGPNTDHCK-KCKHARDGPFCVPECPASKYND---NGVCKSCHGNCVG--------GCEGPENNIGPNGCHSCDKAILNDHVPEG-----------CLQKKESCPDGYY---YEWVSP-----------------------LEQGPLKPLASKAVCRKCHSRCKKCTGYGFHEHVCQECTKYKRGEQCEDECPADYF-----ADANKLCIPCFSEC-RGCFGPGPNQCYKCRNYKIYIDEDTDGNTTSFNCTETCTPEYPHKIFNPDSEPYCSLETAGLIENELQPAILAGVAVFALAFLVVAAIIMYFWRV------RAKAKENTVKMTMALTGLDDNEPLRPTGVKPNLAKLRIIKEEEMRKGGILGYGAFGNVYKGVWVPEGEN--------------------VKIPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMTSQMMLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLLDINEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFG 900
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P13388|XMRK_XIPMA (Melanoma receptor tyrosine-protein kinase OS=Xiphophorus maculatus OX=8083 GN=xmrk PE=2 SV=2) HSP 1 Score: 246.899 bits (629), Expect = 2.753e-65 Identity = 203/647 (31.38%), Postives = 306/647 (47.30%), Query Frame = 2
Query: 608 NNYMKVTANLNKNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNI--------IGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEI-VEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGD----IGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCL--SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCR 2458
N+Y+K+ + C V+ N+ IT N++LSFL SI+E+ G++ + N V +I L NL++IRG+N + E F+L+V+SN + + LK L L IL + V +NP +L I+W I+ K + + PH K C C CW G CQ + C G I+ CC+E C GGC GP T CL C+ FN+ G C + CP +++ V H + N K+TF CV +CP Y + CV C G V+E +C PC +GVCPK C + N +N + NCT +G+II+N S EGD IG P++++ LT +KEI G L I + + +L F+NLEIIR TT ++ + + Q L +LGL+ LKEV G V + N +L Y +++ + + S +I D + E + C+ C + GCWGP CV C H + C+++C+ G + + +C +CH +CL + ++TCYGPG C+ +++ C +CP GDG T C+ CHQ+CT+ C+GP G++GCR
Sbjct: 44 NHYLKM-KKMYSGCNVVLENLEITYTQENQDLSFLQSIQEVGGYVLIAMNEVSTIPLVNLRLIRGQNLY---EGNFTLLVMSNYQKNPSSPDVYQVGLKQLQLSNLTEILSGGVKVSHNP-LLCNVETINWWDIVDKTSNPTMNLIPHAFERQCQK------CDHGCV----NGSCWAPGPGHCQKF---TKLLCAEQCNRRCRGPKPID-CCNEHCAGGCTGPRATDCLACRDFNDDGTCKDTCPPPKIYDIVSHQVVDNPNIKYTFGAACVKECPSNYVVTEGACVRSCSAG-MLEVDENGKRSCKPC-DGVCPKVCDGIGIGSLSNTIAVNSTNIRSFSNCTKINGDIILNRNSFEGDPHYKIGTMDPEHLW--------NLTTVKEITGYLVIMWWPEN--MTSLSVFQNLEIIRGRTTFSRGFS-FVVVQVRHLQWLGLRSLKEVSAGNVILKNTLQLRYANTINWRRLFRSEDQSIE---YDARTENQTCNNECS-EDGCWGPGPTMCVSCLH--VDRGGRCVASCNLLQG----EPREAQVDGRCVQCHQECLVQTDSLTCYGPGPANCS-KSAHFQDGPQCIPRCPHGILGDGDTLIWKYADKMGQCQPCHQNCTQ--------GCSGP----GLSGCR 635 HSP 2 Score: 82.0333 bits (201), Expect = 3.270e-14 Identity = 54/227 (23.79%), Postives = 103/227 (45.37%), Query Frame = 2
Query: 3218 SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
S AP+ L + E + + +L G F + KG W N + + V IKVL E + N++ L + ++ S D P R++ + + + +L QL G L+++++Q+ + +L W Q+A G Y++ +++ D+ N+ +++P + I+D GLSKL + + GK+ I W E+ ++ +S V +Y
Sbjct: 693 SGQAPNQAFLRILKETEFKKDRVLGSGAFGTVYKGLWNPDGEN--------------------IRIPVAIKVLREATSPKVNQEVLDEAYVMASVDHPHVCRLLGICLTSAVQLVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHVKITDFGLSKLLTADEKEYQADGGKVPIKWMALESILQWTYTHQSDVWSYG 899
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|P21860|ERBB3_HUMAN (Receptor tyrosine-protein kinase erbB-3 OS=Homo sapiens OX=9606 GN=ERBB3 PE=1 SV=1) HSP 1 Score: 239.195 bits (609), Expect = 1.609e-62 Identity = 189/651 (29.03%), Postives = 293/651 (45.01%), Query Frame = 2
Query: 524 SFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGN--VIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVV--SNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGV--KHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS---NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
S R + Q C L + N + L + C V+GN +++TG N +LSFL I E+TG++ + N ++ L NL+++RG +Y + KF++ V+ N + L+ L L + IL + + N + + + I W I+ + + EIV N + CH C K CWG S CQ + + C +G QCCH+EC GGC GP +T C C+HFN+ GACV +CP+ LV+N + + N K+ + CV CP + ++ CV C KNG + C PC G+CPK C + Q ++ + NCT GN+ I G G+ W K I + + L ++EI G L N+ S P + F NL I + N+ + L I +N ++ LG + LKE+ G + I N +LCY SL +L +++I +N C E + C LC GCWGP C+ CR++ + +C+++C+ F N E + HE +C CH +C + TC G G+D C C +++ +C CP G N C+ CH++CT+
Sbjct: 15 SLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTG-HNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQ--VY-DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHM-DTIDWRDIV-RDRDAEIVVKDNGRSCPP-------CHEVC-----KGRCWGPGSEDCQTLTKTI---CAPQCNGHCFGP-NPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGL-----KMCEPC-GGLCPKAC--EGTGSGSRFQTVDSSNIDGFVNCTKILGNL---DFLITGLNGDPWHK-IPALDPEKLNVFRTVREITGYL--NIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFS-LLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCS-SGGCWGPGPGQCLSCRNY--SRGGVCVTHCN-----FLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCA-QCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQ 619 HSP 2 Score: 63.1586 bits (152), Expect = 2.216e-8 Identity = 45/206 (21.84%), Postives = 92/206 (44.66%), Query Frame = 2
Query: 3284 ILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+L G F + KG W IP+ E + + V IKV+ + S + + I S D +R++ + + +L Q GSL++ ++Q+ + +L W Q+A G Y++ G+++ ++ N+ ++SP ++ ++D G++ L ++ E K I W E+ + ++ +S V +Y
Sbjct: 714 VLGSGVFGTVHKGVW---------------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYG 898
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q5RB22|ERBB3_PONAB (Receptor tyrosine-protein kinase erbB-3 OS=Pongo abelii OX=9601 GN=ERBB3 PE=2 SV=1) HSP 1 Score: 238.039 bits (606), Expect = 3.059e-62 Identity = 188/651 (28.88%), Postives = 293/651 (45.01%), Query Frame = 2
Query: 524 SFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGN--VIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVV--SNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGV--KHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHS---NQMNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTK 2389
S R + Q C L + N + L + C V+GN +++TG N +LSFL I E+TG++ + N ++ L NL+++RG +Y + KF++ V+ N + L+ L L + IL + + N + + + I W I+ + + EIV N + CH C K CWG+ CQ + + C +G QCCH+EC GGC GP +T C C+HFN+ GACV +CP+ LV+N + + N K+ + CV CP + ++ CV C KNG + C PC G+CPK C + Q ++ + NCT GN+ I G G+ W K I + + L ++EI G L N+ S P + F NL I + N+ + L I +N ++ LG + LKE+ G + I N +LCY SL +L +++I +N C E + C LC GCWGP C+ CR++ + +C+++C+ F N E + HE +C CH +C + TC G G+D C C +++ +C CP G N C+ CH++CT+
Sbjct: 15 SLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTG-HNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQ--VY-DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHM-DTIDWRDIV-RDRDAEIVVKDNGKSCPP-------CHEVC-----KGRCWGSGPEDCQTLTKTI---CAPQCNGHCFGP-NPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGL-----KMCEPC-GGLCPKAC--EGTGSGSRFQTVDSSNIDGFVNCTKILGNL---DFLITGLNGDPWHK-IPALDPEKLNVFQTVREITGYL--NIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFS-LLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCS-SGGCWGPGPGQCLSCRNY--SRGGVCVTHCN-----FLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCA-QCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQ 619 HSP 2 Score: 63.1586 bits (152), Expect = 1.825e-8 Identity = 45/206 (21.84%), Postives = 92/206 (44.66%), Query Frame = 2
Query: 3284 ILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+L G F + KG W IP+ E + + V IKV+ + S + + I S D +R++ + + +L Q GSL++ ++Q+ + +L W Q+A G Y++ G+++ ++ N+ ++SP ++ ++D G++ L ++ E K I W E+ + ++ +S V +Y
Sbjct: 714 VLGSGVFGTVHKGVW---------------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYG 898
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1B1ACY8 (Epidermal growth factor receptor Smed-egfr-6 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 2524.97 bits (6543), Expect = 0.000e+0 Identity = 1265/1266 (99.92%), Postives = 1265/1266 (99.92%), Query Frame = 2
Query: 401 KPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHDTRPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIYHVESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN 4198
KPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMSLLKLYSNNSSLKMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYIAAVGGSVVSVLAVGIVWKCICMSLNKRKRYDLKLKF NGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHDTRPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIYHVESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN
Sbjct: 18 KPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMSLLKLYSNNSSLKMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYIAAVGGSVVSVLAVGIVWKCICMSLNKRKRYDLKLKFPNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHDTRPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIYHVESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN 1283
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1B1ACY9 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 882.093 bits (2278), Expect = 0.000e+0 Identity = 484/1205 (40.17%), Postives = 701/1205 (58.17%), Query Frame = 2
Query: 539 DSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSS-NFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYIS-KNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD--IESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN-------------------------------------------------SDHDTRPNLRKLKQSIEMIMKNPCSFIILQ 3994
D H C S D+ N+Y + N +KNC+++IG+V+I ITNEN+SFLNSIE+I+G+L +FSN+VESISL LK+IRGENP + + +KFSL+V N +ML+ ++ P QVIL+HN+ NNP + Y I+WNS++ + Q + IVE + SK +LSCH SCQ H+ K +CWGNSS CQ INDC +TC S+KC++ LK E+CCHEECVGGC GP +QCL CK+FNN G CVE CP + H+G+K+I+N L K F+ CVDKCP K+F E+ CV +C TYAVN+TC+PCPNG CPK C +D++ + I Y++RK+L RLENCTVY GNI+IN S+EGD + K GI+ +DL+KL NL+EIYG L I+V + W +L + +NL IIRAE + G+ I N L +LGL+ LKEVRNG + I +N +LC++++LTNKSILH + NGK C +KC C + GCWGP CVKC+ F I E C+S CS +PGYFYN + CS+CH++CL TC+G ++C GC NYK+ + C +KCP +Y D + C CH +CT EN + + TC GP + +G GC CN++ + +N S + + + L C+ +S+ C G++K +DF S + + S +LE WI+ NH+ ++CLPCHP CS+C G+ C CK R +C+ C ++ +I+ ++ ES C KCHEEC EGC GST YDC +CK KIY+N S T+FFCNS CGD ++F SE++C L + + YI G + + + V I+ I S N+ K++ KL F D S P+ LL I E Q + I+ G F I+ KG W + + S K + KI D + LNV +K+L++ SD ++N++ L++ K++ S D P LRI+ V + A+ +L Q GSL+EF+++N S++ I++L+WA Q+ASG Y++ +GII+ D+ N+ I+SP ++ I+D GL+K+ + + + K G++ I W E ++ FSSKS V +Y D D RP+ +L+++ EM+ NP ++++Q
Sbjct: 82 DKRYRHGKVCKSTQTQIDV--SKNSYESLKRNFDKNCSYIIGDVVIAHITNENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQEVVIVETNEKDCGLNSKIDEELSCHESCQAHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILKSEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPKICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGRFLRALNGKIENCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYYVDSMKN--CYPCHTNCT-ENSQNKESTCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKV------NAAMQSTMKILEKWIEIGTNHDLPIASVCLPCHPYCSECHGGSSWHCSLCKYFRSDNKCIQKCPKEYFITVTETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGS-TQFFCNSTCGDRIQLFQTSEIICT--DHLIYSRFNMYIYIGGPAGIVISFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQ 1268
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1L8DJK4 (Receptor protein-tyrosine kinase OS=Nyssomyia neivai OX=330878 PE=3 SV=1) HSP 1 Score: 380.563 bits (976), Expect = 1.459e-106 Identity = 332/1240 (26.77%), Postives = 536/1240 (43.23%), Query Frame = 2
Query: 275 LRRYQTISQLSLLVV*QVYRRNIFDMGXXXXXXXXXXXXXXXKPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGI--TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGD----IGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSL----TNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGA---ICLPCHPLCSQCSDGTIES--CHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSK----TKFFCNSICGDNFRI-------FVNSEMVCVQPQELKPIQNSW-YXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIE-SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+R Y + L LL V +G + R +P HH++ L V D+Q SEF ++ S+ DH Y ++RD+ NCT+V GN+ +T + T +LSFL I E+TG++ + ++ I L L+IIRG + + +F L V + + L +P + IL ++ ++NN + + + I W I+ H NFTS E SCH +CQ CWG CQ + +CF K +CCH C GGC GP CL C++F + G C ++CP +N ++ N K+ + TCV CP+ +N CV C A N C+PC NG CPK C + +V + NI + CTV G++ I + G + + + LE + LKE+ G IN+ + L YFRNLE+I + L I + L L LQ LK + +G V I+ N LC+ D + KS H+ ++ N + + E + CS C K GCWG C++CR+++ + C+++C PG + + NH T C CH++C +S C+G GAD CT CVN + ++C KCP+ Y G T CK CH++C CTGP N I GC+ C+ + + NG + I R C+ + C +GY+ W+ Q + A IC CHP C +CS C C ++RG++C C D ++ + + C CH EC GC G TE C QC+ K++ N + F C + C ++ + +S V Q + + ++ + ++ V ++V ++AV VW+C K + + + + + + S+ P+ KL I E + + IL +G F + G W ++ + + + V IKVL++ S +K+FL + I+ S D P LR++ V + + L QL +G L+++++ N + ++L W+ Q+A G Y++ I++ D+ N+ +++ + I+D GL+KL + K GK+ I W E ++ F+SKS V +
Sbjct: 1 MRGYLIVGLLVLLAV--------ESLGALERVQRPEGGKRFDRPRKQHHQQHQLTTDLAP-KVPQDDKQPSEFVKGKICIGTNGRMSVPSNRDHH--------YRNLRDR-----------FTNCTYVDGNLELTWLQDTKLDLSFLQHIREVTGYVLISHVDIQQIVLPRLQIIRGRTLFKLNISDQEFGLFVTYS-----QMHTLEMPALRDILSGSVGIFNNYNLCHMRT-IDWEEIISGPN----ASMHYMYNFTSPERQCASCHPTCQAG-----CWGEGPHNCQQFSKTTCSPQCAQGRCF---GPKPRECCHLFCAGGCTGPTQKDCLACRNFYDDGVCKQECPPMQKYNPTNYLWEPNPDGKYAYGATCVRNCPEHLLKDNGACVRTCPPNKM-AKNGECVPC-NGACPKTCPGQGIVHSGNID--------SFKGCTVIEGSLEILEQTFNGYQHVFANFSFGQRFIRLHPDRLEVFSTLKEVTGY--INIQADHEHFTNLSYFRNLEVIGGRQLMENYFASLYIVKT-SLKSLELQSLKRINSGSVVILENKNLCFADDIEWNKVKKSSDHACVVSANRNKTECELEGQVCSDQCT-KTGCWGAGSNQCLECRNYKYND--TCLASCQSFPGIY--EVNHTT----CGTCHSECKNS---CHGAGADNCT-ECVNVRDGNFCVAKCPESKYSAGGT---CKPCHETCIG---------CTGPQNTINAYGCKTCH--KAIING-DATIER-------CLGRNEACPEGYYS-----------------------------EWVMSQEQGALRLLANKPICRRCHPRCKKCSGYGFHEHVCQECAGYKRGEQCEDECPTDHFVDETTRE----CFACHLEC-RGCNGPTEAHCLQCRNYKLFGNGDPANNGSAFNCTAACPSDYPYQMFDYGPYCSSSNV-YQLSDDEFVKKVFSFVGIVILALVVLIAVAFVWRCCQKQKAKEETVKMTMVLAGCEDSEPLRPSNVGPNLAKLRIIKEAELRHGRILGMGAFGRVFGGYWYPENQS--------------------IKVPVAIKVLTDMSGSESSKEFLDEAYIMASVDHPNLLRLLAVCMSSQMMLITQLMPSGCLLDYVRTNKEKIGSKALLSWSKQIAKGMAYLEERSIVHRDLAARNVLVQNANSVKITDFGLAKLLDVGTDEYKASGGKMPIKWLALECIRNRVFTSKSDVWAFG 1091
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A1L8DJK1 (Receptor protein-tyrosine kinase (Fragment) OS=Nyssomyia neivai OX=330878 PE=4 SV=1) HSP 1 Score: 379.793 bits (974), Expect = 2.467e-106 Identity = 333/1240 (26.85%), Postives = 535/1240 (43.15%), Query Frame = 2
Query: 275 LRRYQTISQLSLLVV*QVYRRNIFDMGXXXXXXXXXXXXXXXKPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGI--TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGD----IGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSL----TNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGA---ICLPCHPLCSQCSDGTIES--CHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSK----TKFFCNSICGDN--FRIF------VNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIE-SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+R Y + L LL V +G + R +P HH++ L V D+Q SEF ++ S+ DH Y ++RD+ NCT+V GN+ +T + T +LSFL I E+TG++ + ++ I L L+IIRG + + +F L V + + L +P + IL ++ ++NN + + + I W I+ H NFTS E SCH +CQ CWG CQ + +CF K +CCH C GGC GP CL C++F + G C ++CP +N ++ N K+ + TCV CP+ +N CV C A N C+PC NG CPK C + +V + NI + CTV G++ I + G + + + LE + LKE+ G IN+ + L YFRNLE+I + L I + L L LQ LK + +G V I+ N LC+ D + KS H+ ++ N + + E + CS C K GCWG C++CR+++ + C+++C PG + + NH T C CH++C +S C+G GAD CT CVN + ++C KCP+ Y G T CK CH++C CTGP N I GC+ C+ + + NG + I R C+ + C +GY+ W+ Q + A IC CHP C +CS C C ++RG++C C D ++ + + C CH EC GC G TE C QC+ K++ N + F C + C + +++F +S + + E S ++ V ++V ++AV VW+C K + + + + + + S+ P+ KL I E + + IL +G F + G W ++ + + + V IKVL++ S +K+FL + I+ S D P LR++ V + + L QL +G L+++++ N + ++L W+ Q+A G Y++ I++ D+ N+ +++ + I+D GL+KL + K GK+ I W E ++ F+SKS V +
Sbjct: 6 MRGYLIVGLLVLLAV--------ESLGALERVQRPEGGKRFDRPRKQHHQQHQLTTDLAP-KVPQDDKQPSEFVKGKICIGTNGRMSVPSNRDHH--------YRNLRDR-----------FTNCTYVDGNLELTWLQDTKLDLSFLQHIREVTGYVLISHVDIQQIVLPRLQIIRGRTLFKLNISDQEFGLFVTYS-----QMHTLEMPALRDILSGSVGIFNNYNLCHMRT-IDWEEIISGPN----ASMHYMYNFTSPERQCASCHPTCQAG-----CWGEGPHNCQQFSKTTCSPQCAQGRCF---GPKPRECCHLFCAGGCTGPTQKDCLACRNFYDDGVCKQECPPMQKYNPTNYLWEPNPDGKYAYGATCVRNCPEHLLKDNGACVRTCPPNKM-AKNGECVPC-NGACPKTCPGQGIVHSGNID--------SFKGCTVIEGSLEILEQTFNGYQHVFANFSFGQRFIRLHPDRLEVFSTLKEVTGY--INIQADHEHFTNLSYFRNLEVIGGRQLMENYFASLYIVKT-SLKSLELQSLKRINSGSVVILENKNLCFADDIEWNKVKKSSDHACVVSANRNKTECELEGQVCSDQCT-KTGCWGAGSNQCLECRNYKYND--TCLASCQSFPGIY--EVNHTT----CGTCHSECKNS---CHGAGADNCT-ECVNVRDGNFCVAKCPESKYSAGGT---CKPCHETCIG---------CTGPQNTINAYGCKTCH--KAIING-DATIER-------CLGRNEACPEGYYS-----------------------------EWVMSQEQGALRLLANKPICRRCHPRCKKCSGYGFHEHVCQECAGYKRGEQCEDECPTDHFVDETTRE----CFACHLEC-RGCNGPTEAHCLQCRNYKLFGNGDPANNGSAFNCTAACPSDYPYQMFDYGPYCSSSNVYQLSDDEFVKKVFS-FVGIVILALVVLIAVAFVWRCCQKQKAKEETVKMTMVLAGCEDSEPLRPSNVGPNLAKLRIIKEAELRHGRILGMGAFGRVFGGYWYPENQS--------------------IKVPVAIKVLTDMSGSESSKEFLDEAYIMASVDHPNLLRLLAVCMSSQMMLITQLMPSGCLLDYVRTNKEKIGSKALLSWSKQIAKGMAYLEERSIVHRDLAARNVLVQNANSVKITDFGLAKLLDVGTDEYKASGGKMPIKWLALECIRNRVFTSKSDVWAFG 1096
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Match: A0A0U3TFJ4 (Receptor protein-tyrosine kinase OS=Leptinotarsa decemlineata OX=7539 PE=2 SV=1) HSP 1 Score: 378.637 bits (971), Expect = 8.229e-106 Identity = 322/1138 (28.30%), Postives = 508/1138 (44.64%), Query Frame = 2
Query: 605 PNNYMKVTANLNK---NCTHVIGNVIITGITNENL--SFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIY--REVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILG--KHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYG-----IQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSIL--HSNQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFG-AICLPCHPLCSQCSDGTI--ESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNS----SKTKFFCNSICGDNF--RIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLN-------KRKRYDLKLKFSNGFSTVDIESDFAPSS-----TKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
P+N + NL + NCT+V GN+ +T + +NL SFL I E+TG++ + V+ + L +L+IIRG + R+ +F+L+V + + YL LP + +L+ N+ +NN + + K I+W I+ K F + NF S E CH C+ CWG+ CQ + +CF K +CCH C GGC GP + C+ C++F + G C ++CP ++N + N KF + TCV KCP+ +N CV C +AV+ C+PC G CPK C + NIQ +NCTV GNI I S +G + +P +G + L + LKEI G L N+ + P K L YF NLE+I ++ T + I + L L L+ LK + G V I+ N LC + + I H N + + NN C+AR C + C K GCWGP C+ C HF++ K C+ NCS G Y EN+ +C CH QC SS C+GPGA+ CT C + + ++C KC Q+ Y + + +CK CH +C +CTGP +G GC C ++ + C+H +NC DGY+ + H I + + + G IC CHP C +C+ SC +C +++G++C C D Y N++ C+ C +EC GCTG +C C+ KI+++ + T F C + C +F ++F + ++ S Y V+ + AV + +S+ K K + +K + + ++ PS+ KL I E + IL G F + KG W + + + V IKVL E + ++KDFL + I+ S D P L+++ V + + L QL G L++F++ N + S+L W+ Q+A G Y++ + +++ D+ N+ +++P + I+D GL+KL + K GK+ I W E + F+ KS V +
Sbjct: 25 PSNRERHYRNLKERYTNCTYVDGNLELTWLQEDNLDLSFLQYIREVTGYVLISHVDVKRVVLPSLQIIRGRTLFKMNVRDEEFALIVTLS-----KMYYLELPALRDVLKGNVGSFNNYNLCHVKT-INWKEIMSDSKGNFSYVY------NFASPERECPPCHKDCE-----HGCWGDGRENCQQFSKEFCSPQCFQGRCF---GPKPRECCHLFCAGGCTGPKQSDCIACQNFYDDGVCTQECPPMQLYNPTTYSWEPNPNGKFAYGATCVKKCPEHLLKDNGACVRTCPPNK-HAVDGECVPC-EGPCPKTCSGDGTIHFGNIQ--------NFKNCTVLEGNIDILENSFKG-FQSVFPNYTFGDRYPAMHPSALSVFSTLKEITGYL--NIQAYHPDFKNLSYFSNLEVIGGRAL-YEYSTSVYIVKT-SLESLDLRSLKRINMGTVAILENKHLCLAEGINWDLIRKSHDNHLMLSNNSDLNSCKARGLVCDEQCS-KDGCWGPGPDQCLSCAHFRLGTK--CLENCSVVSG--YRAENN-----ECKPCHEQCGSS---CHGPGANNCT-SCKHLQDGNFCVSKCSQNKYEE---NGVCKECHANCVD--------SCTGPSEILGEGGCNSCE------------LAIMDDTNYVCLHKKDNCPDGYYYEYVGQH-------------------------IQEETSLKLLAGKGICRKCHPRCKECTGYGFHESSCQKCMQYKKGEQCEDECTPDYYPDVNTNE----CIACDDEC-RGCTGPGPENCVVCQNFKIFIDGNNDDNNTAFVCVASCPADFPHKVFPDDGHASAFCSDVATSSYSVYPKNPYDIVIIIGAVIGGIFLLILSIGFICYYQRKEKIKENAMKMTMALTGLEDNEPLRPSNVMPNIAKLRIIKETEIRRGTILGYGAFGTVYKGVWVLEGETS-------------------AKIPVAIKVLRENTGANNSKDFLDEAYIMASVDHPNLLQLLAVCMSSQMMLVTQLMPLGCLLDFVRTNRDRIGSKSLLNWSTQIARGMAYLEEKRLVHRDLAARNVLVQTPACVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAF 1041
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:NCBI gene;Acc:103042851]) HSP 1 Score: 241.121 bits (614), Expect = 3.088e-64 Identity = 190/642 (29.60%), Postives = 300/642 (46.73%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGITN-ENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAV--------NETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMN--IYNNGKDGK-CEAR--KCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGD-------GSTSNICKACHQSCTKENLFSFKRTC-----TGPGNHIGV 2446
N+ ++ L +C V GN+ IT + ++LSFL I E+ G++ + SV I LKNL+IIRG +Y F+L + N ++ L IL + ++ NP + Y +N I+W I+G + + + ++ + + SC ++C G R CWG ++ CQ + R C +S C CCH +C GC GP ++ CL C+HFN+ G C + CP ++++ + + N +KF+F TCV +CP Y C C + + C C +G CPK C + + +N + + C +G++ T S +GD + N+ +Q DLE L+EI G L I+ + W L F NL++IR K + L + Q+ + LGL+ L+ V G+V + NNP+LCYT SL S+L+ +Q I NN ++ + CEA +C LC CWGP CV C+ +Q C+ C+ G + C CH +C ++ + +C GPGAD C C+NY+ D C ++CP+ GD + S C C +C+ N + +R C +GPG I
Sbjct: 42 NHYEMLRLLYTDCQVVHGNLEITHLQGKQDLSFLEGIVEVQGYVLIAHVSVPVIPLKNLRIIRGSQ--LYNS-SFALAALEN----PQVEQLQFSSLTEILLGEVYIWGNPQLCYPRN-INWKDIVGDSKSIRV---QSAVPYCT------SCPATC----GSRGCWGRAAEDCQTLT---RIPC--ASGCTRCKGPDASDCCHVQCAAGCSGPKDSDCLACRHFNDSGTCRDNCPPPIIYDPLTYQSKPNPNKKFSFGATCVKQCPHNYLAMEVACTLVCPKANQEVITIEPDAQETQKCEKC-DGECPKVCYGLGMGSLQRVMAVNSSNIGLFKGCKKIYGSLAFLTQSFKGDPFS----NLSSLQPDDLEVFRTLEEITGYLYIDAWPQN-W-TDLGVFENLKVIRGRML-YKGVFSLGV-QSLQIESLGLRSLRSVSGGLVLVHNNPQLCYTSSLPWSSLLYPSQEPNLISNNNREPQACEAEGHQCDPLCK-DGACWGPGPSQCVSCKSYQ--RGTECVEQCNIWSGL----QREFIDGSSCIPCHAECRPINGSASCIGPGADDCK-ECLNYQDGDMCVDQCPKSIKGDRHNVWKYSNESGYCLPCPHNCSL-NCLTDERGCPIQQKSGPGTTIAA 639 HSP 2 Score: 94.7449 bits (234), Expect = 5.392e-19 Identity = 99/421 (23.52%), Postives = 170/421 (40.38%), Query Frame = 2
Query: 2720 CHPLC--SQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECME-----GCTGSTEYDCKQCKRVKIYLNSSKTKFFC-NSICGDNFRIFV-------------NSEMVCVQPQELKPIQN-SWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSST-----KLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
C PLC C C CKS++RG ECV C + + + S C+ CH EC C G DCK+C Y + C SI GD ++ N + C+ + PIQ S + ++ V+ I+ + L ++KR K ++ PS ++ + E + +L G F + KG W PD E V + V IKVL E + NK+ L + ++ P+ R++ + + + +L QL G L++++++N + +L W Q+A G Y++ +++ D+ N+ ++SP + I+D GL++L + GK+ I W E+ + F+ +S V +Y
Sbjct: 497 CDPLCKDGACWGPGPSQCVSCKSYQRGTECVEQCNIWSGLQREFIDGSS-CIPCHAECRPINGSASCIGPGADDCKECLN---YQDGDMCVDQCPKSIKGDRHNVWKYSNESGYCLPCPHNCSLNCLTDERGCPIQQKSGPGTTIAAAMGGVVLFLILLALLIFYLRRQKRMKKKETMRRILQEHELVEPLTPSGAMPNQAQMRILKETELKKLRVLGSGAFGTVYKGIWA---------------------PDGEKVKIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDHIGSQYLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYG 892
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: ENSAMXT00000051131.1 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492]) HSP 1 Score: 236.113 bits (601), Expect = 8.728e-63 Identity = 205/685 (29.93%), Postives = 322/685 (47.01%), Query Frame = 2
Query: 590 DIRDKPNNYMKVTANLNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENM----------LKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTC--KLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNET----CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNI--YNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNIT--CYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCR-KCNYVQLLTNGSEGFISRFTVHSLTCI 2539
++ + +++ + + NCT V+ N+ IT + N +LSFL SIEE+ G++ + N V I L+NL++IRG + + E KF+L V++N N L+ L L + IL+ + + NP + + I W+ I+ K ++ S++ T K D SC++ CW CQ + R C + S +C I CC+E C GC GPL T CL C+ F + G C + CPR ++++ H + N KF+F TCV CP Y + ++ CV C + T+ V E C C NG CPK C + I +N + +NCT +G+I I ++ GD PK + L+ +KEI G L I + L +L F NLE+IR T + ++ ++N + +LGL+ LKE+ +G V I NNP+LCYT++ + + S+ I +N CE R C +C + GCWGP C CRH ++ + C+ +C+ G + ++ M C +C +C + N T C+GPGADQC C ++K C +C G + + C+ CH +CT CTGP G+ C + + V ++ +G G + F V CI
Sbjct: 35 NLLSQADDHYRALMKMYSNCTVVLENLEITHVGENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHSLY---EGKFALAVMANYHTANSSSAESSIPTGLRELPLRNLREILRGGVRIARNPRLCNIET-IKWHDIVSKESTNAVIT-SESTDSTCKPC-DKSCYNGS--------CWAPGPENCQKL---TRLICAEQCSHRC---KGPAIADCCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFSFGATCVKNCPHNYVVTDHGACVRTCGD-KTHEVEENGIRKCKNC-NGPCPKVCNGLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPK----LDPAKLDYFKTVKEITGFLLIQAWPEN--LTSLSPFENLEVIRGRTQQHGRVSFAALNIA-HIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQTIKTRDNLAPEACEVQNRMCDGMCT-EEGCWGPGPSMCFSCRH--VSRQGQCVDSCNILEGM---PREYISNNM-CLECDQECRTLNGTPSCHGPGADQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDKNRQCQPCHPNCT--------HGCTGP----GLKSCETQSSQVSMVASGVVGGL-LFVVIVFLCI 669 HSP 2 Score: 85.5001 bits (210), Expect = 3.290e-16 Identity = 58/227 (25.55%), Postives = 106/227 (46.70%), Query Frame = 2
Query: 3218 SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
S AP+ L + E + +L G F + KG W IP+ E V + V IKVL E + NK+ L + ++ S D P R++ + + + +L QL G L++++++N + ++L W Q+A G Y++ +++ D+ N+ +++P + I+D GL+KL N + GK+ I W E+ ++ +S V +Y
Sbjct: 700 SGAAPNQALLRILKETEFKKVKVLGSGAFGTVYKGLW---------------------IPEGEDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQLITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSY 905
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: ENSAMXT00000047506.1 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492]) HSP 1 Score: 235.728 bits (600), Expect = 9.738e-63 Identity = 205/685 (29.93%), Postives = 322/685 (47.01%), Query Frame = 2
Query: 590 DIRDKPNNYMKVTANLNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENM----------LKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTC--KLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNET----CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNI--YNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNIT--CYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCR-KCNYVQLLTNGSEGFISRFTVHSLTCI 2539
++ + +++ + + NCT V+ N+ IT + N +LSFL SIEE+ G++ + N V I L+NL++IRG + + E KF+L V++N N L+ L L + IL+ + + NP + + I W+ I+ K ++ S++ T K D SC++ CW CQ + R C + S +C I CC+E C GC GPL T CL C+ F + G C + CPR ++++ H + N KF+F TCV CP Y + ++ CV C + T+ V E C C NG CPK C + I +N + +NCT +G+I I ++ GD PK + L+ +KEI G L I + L +L F NLE+IR T + ++ ++N + +LGL+ LKE+ +G V I NNP+LCYT++ + + S+ I +N CE R C +C + GCWGP C CRH ++ + C+ +C+ G + ++ M C +C +C + N T C+GPGADQC C ++K C +C G + + C+ CH +CT CTGP G+ C + + V ++ +G G + F V CI
Sbjct: 25 NLLSQADDHYRALMKMYSNCTVVLENLEITHVGENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHSLY---EGKFALAVMANYHTANSSSAESSIPTGLRELPLRNLREILRGGVRIARNPRLCNIET-IKWHDIVSKESTNAVIT-SESTDSTCKPC-DKSCYNGS--------CWAPGPENCQKL---TRLICAEQCSHRC---KGPAIADCCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFSFGATCVKNCPHNYVVTDHGACVRTCGD-KTHEVEENGIRKCKNC-NGPCPKVCNGLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPK----LDPAKLDYFKTVKEITGFLLIQAWPEN--LTSLSPFENLEVIRGRTQQHGRVSFAALNIA-HIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQTIKTRDNLAPEACEVQNRMCDGMCT-EEGCWGPGPSMCFSCRH--VSRQGQCVDSCNILEGM---PREYISNNM-CLECDQECRTLNGTPSCHGPGADQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDKNRQCQPCHPNCT--------HGCTGP----GLKSCETQSSQVSMVASGVVGGL-LFVVIVFLCI 659 HSP 2 Score: 85.8853 bits (211), Expect = 2.563e-16 Identity = 58/227 (25.55%), Postives = 106/227 (46.70%), Query Frame = 2
Query: 3218 SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD-ELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
S AP+ L + E + +L G F + KG W IP+ E V + V IKVL E + NK+ L + ++ S D P R++ + + + +L QL G L++++++N + ++L W Q+A G Y++ +++ D+ N+ +++P + I+D GL+KL N + GK+ I W E+ ++ +S V +Y
Sbjct: 690 SGAAPNQALLRILKETEFKKVKVLGSGAFGTVYKGLW---------------------IPEGEDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQLITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSY 895
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 233.802 bits (595), Expect = 4.949e-62 Identity = 197/657 (29.98%), Postives = 296/657 (45.05%), Query Frame = 2
Query: 644 NCTHVIGNVIITGITNE-NLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTC--KLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKH--IKNRLEKFTFHNTCVDKCPDKYFI-ENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQND-DLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQ--MNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGST--------SNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRK---CNYVQLLTNGSEGFISRFTVHSL 2530
NCT ++ N+ IT ++E +LSFL SIEE+ G++ + N I L NL+IIRG +Y +L V+SN L+ L L IL+ + +NP + + I W I+ + V+ ++++ K CHS C CW CQ + TC + S +C K CC+ C GC GP T CL C+ F + C + CP +++N H N K+ F TCV CP Y + ++ CV C G TY V+E C C G+CPK C V + +N + ENCT +G+++I ++ GD PK + L +KEI GSL + K + +L F NLE+IR T KH +S+ + LGL+ L+E+ +G V I N KLCY K + S N C A + C ++C P+ GCWGP C C+H+ + K C++ C+ G E + M C +C +C L+ ++TC PG D C C +++ +C +CPQ G+ T +C+ CHQ+CT+ CTGP + CR+ + + ++ G G I F + SL
Sbjct: 61 NCTVILENLEITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGHT--LYD--GLALAVLSNYNNSKGLRELPLISLTEILKGGVKFAHNPYLCNVET-IQWADIMSSKDSSQFVKFESTTSKDCK-----MCHSDCY----NGSCWAPGRANCQTF---TKLTCAEQCSGRC---KGPKPSDCCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPG-TYEVDEDGVRKCKKC-EGLCPKVCSGLGVGNLVGVMSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPK----MDPAKLNVFRTVKEITGSLLVQYWPKN--MPSLSPFENLEVIRGRT---KHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPE-GCWGPGPTMCFSCKHY--SRKKSCVAFCNLLEGEHRECEVN----MTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQ--------GCTGP----ELKDCREYKPFSGMSVIAAGVVGGILAFVILSL 666 HSP 2 Score: 105.145 bits (261), Expect = 2.915e-22 Identity = 94/418 (22.49%), Postives = 160/418 (38.28%), Query Frame = 2
Query: 2684 NHEYQFGAICLPCHPLCSQ------CSDGTIESCHRCKSHRRGKECVHNCY-----EDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGD--NFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+ E + CL C P C CS + C C R G CV C E D + ++ +C CH+ C +GCTG DC++ Y S + G F I V V+ + +K RKR +L S AP+ + L + E + +L G F + KG W + E V + V IKVL E + NK+ L + ++ S + P R++ + + + +L QL G L++++K+N + +L W Q+A G Y++ +++ D+ N+ +++P + I+D GL+KL + + GK+ I W E+ + ++ +S V +Y
Sbjct: 548 HRECEVNMTCLECDPECRPLNGSLTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCRE------YKPFSGMSVIAAGVVGGILAFVILSLGVAVLVRRRHIK----------------------------------RKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFKKIKVLGSGAFGTVYKGLWVPEG--------------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQLVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYG 905
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Match: erbb4b (erb-b2 receptor tyrosine kinase 4b [Source:ZFIN;Acc:ZDB-GENE-030918-5]) HSP 1 Score: 233.032 bits (593), Expect = 1.165e-61 Identity = 184/619 (29.73%), Postives = 279/619 (45.07%), Query Frame = 2
Query: 641 KNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGV--KHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH-SNQMNIYNNGKDGK---CEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN---ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTGP 2428
+NC V+GN+ IT I + +LSFL SI E+TG++ + N + + L+NL+IIRG + E +++L + N G L+ L L IL + V N L + IHW I+ + +V P NSS+ + CH +C G+ CWG QCQ + V + C +CF + CCH EC GGC GP +T C C +FN+ GACV +CP+ V+N + N K+T+ CV KCP + +++ CV C + + C+PC + +CPK C Q ++ + + NCT +GN++ I+GD+ + NI + + L ++EI G +++L F I L + + + L LQ ++E+ G V I NN +LCY +++ S+ Q + N +D K E C LC GCWGP C+ CR F + C+ +C+ G N C +C QC ++ +TC GPG D C C+++K C EKCP G S +N C CH +CT+ CTGP
Sbjct: 23 ENCEVVMGNLEITSIDRSRDLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGTRLY---EDRYALAIFLNYRRDGNFGLRQLGLKNLTEILHGGVYVDQN-KFLCHADTIHWQDIVKNARSDHLVVPSNSSSSCQR------CHRACN---GR--CWGPKENQCQSLTKTVCAEQC--DGRCF---GPYVSDCCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPRAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENKIKMCIPCTD-ICPKACDGIGTASLQTAQTVDSSNIDKFINCTKINGNLVFLITGIKGDVYH----NIEALDPEKLNVFRTVREITGK-----------TRSILTFSGRGI------------SLLVLKQQWITSLQLQSMREISAGNVYITNNSQLCYYNTINWTSLFRIPTQKALIRNNRDPKECIMEKMICDPLCS-DGGCWGPGPDQCLSCRFF--SRGRTCVESCNLHQGDVREFANGSV----CLECDAQCQKADDDGLTCTGPGPDHCV-KCLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANNECHPCHANCTQ--------GCTGP 577 HSP 2 Score: 100.908 bits (250), Expect = 6.822e-21 Identity = 92/415 (22.17%), Postives = 161/415 (38.80%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E+ G++CL C C + D + + C +C + G CV C D NS + A + C CH C +GCTG DC +T + G F + + + V V + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L + + GK+ I W E + + F+ +S V +Y
Sbjct: 493 REFANGSVCLECDAQCQKADDDGLTCTGPGPDHCVKCLHFKDGPNCVEKC-PDGLQGTNSFIFKYAEANNECHPCHANCTQGCTGPRLQDCIGM--------IDRTPLIAAGVIGGLFVVVIIALGVAVSVRR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKILGAGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSY 845
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010487.1 (pep scaffold:Pmarinus_7.0:GL501102:818:30108:-1 gene:ENSPMAG00000009497.1 transcript:ENSPMAT00000010487.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 198.749 bits (504), Expect = 1.503e-53 Identity = 171/617 (27.71%), Postives = 270/617 (43.76%), Query Frame = 2
Query: 635 LNKNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNI---IGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIK--NRLEKFTFHNTCVDKCPDKYFIENEKCVPKC--------KNGATY--AVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKC----EARKCSKLCHP---KYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDH--------YGDGSTSNICKACHQSCT 2386
L + C V+GN+ IT ++ ++LSFL + E+ G++ + N E + L++L+I+RG +Y + KF+L +V N +G L+ L+L IL + + +NP L + I W IL + + V P+ + S C C CW + CQ + R C YG QCCH+ C GC GP +T CL CK FN+ G CV CP ++N +++ N K++ CV +CP + I+ C C +NG A +E CP VC ++ ++ LN + CT +GN++ ++ D+ + ++ +++EI G L I + P + L F NLEI+R + + L + L LGL+ L EV G V N P+LCY ++ +L S + G R S+ CHP GCWGP C++C+ F+ C+ +C++ G N C+ CH++CL +N ++C GP +D CT C ++K YC +KCP + N C CH +CT
Sbjct: 50 LYQGCEVVLGNLEITHLSRGDDLSFLKDVREVMGYVLVALNDFEELPLESLRIVRGMK--LYDD-KFALAIVDNGQRGLGTG-LRALLLRSLTEILSGGVNITDNP-FLCHADTIKWEDILEQKNLNQSVLPYGRPDCESPA-SRPPCPQGCS------HCWSADTNYCQKLT---RTICAKECTLRCYGT-NTNQCCHKHCASGCTGPRDTDCLACKTFNDTGVCVMHCPPTHIYNRDTYLQEPNPDVKYSHGAICVKRCPQNFLIDENSCARSCPHEKMEVEENGVKMCKACSEK-QGCPKVVC-HGIGSGNLKDAKSVSSLN---VDTFSECTTINGNLVFLESGLDSDL---------LAHPEKMKVFRSVREITGYLHIE--AWLPNMTDLSVFENLEIVRGRNIRSVGYSVL-VRNLPHLEVLGLRALSEVTEGSVLAQNVPRLCYVLTVNWTRLLRSPRQKADLEGVPSSSVCVFACRAGSEACHPLCSSDGCWGPGPEQCMQCKLFK--RGRTCVESCNQNDGEVREFINGTL----CTPCHSECLPTNGTLSCKGPTSDMCTR-CRHFKDGPYCVDKCPLGQNTEHGALIFKFPDAHNACMPCHANCT 626 HSP 2 Score: 49.6766 bits (117), Expect = 4.829e-6 Identity = 30/82 (36.59%), Postives = 41/82 (50.00%), Query Frame = 2
Query: 2720 CHPLCSQ--CSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECME-----GCTGSTEYDCKQCKRVK 2944
CHPLCS C E C +CK +RG+ CV +C ++D + N +LC CH EC+ C G T C +C+ K
Sbjct: 507 CHPLCSSDGCWGPGPEQCMQCKLFKRGRTCVESCNQNDGEVREFING-TLCTPCHSECLPTNGTLSCKGPTSDMCTRCRHFK 587
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 191.815 bits (486), Expect = 4.134e-50 Identity = 153/520 (29.42%), Postives = 231/520 (44.42%), Query Frame = 2
Query: 905 ILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIK--NRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN------ETCLPCPNGVCPKDCLIKDVVQNYNI---QYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLT-GLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMN--IYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDG--------STSNICKACHQSCT 2386
IL + + N + Y N + W I+ + + I + NS+ TS CH C H CWGN CQ C + TC +G E CCH +C GC GP +T C CK+FN+ G+CV CP ++N V + N K+++ CV +CP + ++ CV C G ETC VCPK C D + N+ Q ++ + ENCT +GNI T I+GD P + L ++KEI G L I + + F NL IR + T L + + ++ LGL L+EV G V + NN +LCY +++ ++ S Q +++N + C A C LC ++GCWGP C+ CR F+ C+ +C G + +E+ Q + C+ C +CL N +TC+GPG++ C C +YK +C CP G+ +N C+ CH +C+
Sbjct: 4 ILHGGVYIKENKHLCY-HNTVDWWDIVKEGSIVNI-DMDNSTTCTS-------CHKGCHKH-----CWGNGMKYCQ---KCTKLTCARQCDGRCHGPTPSE-CCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKFGKKKCETC----TDVCPKAC---DGIGTGNLSRSQTVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPP----LDPDKLNVFRSIKEITGHLMIQAWPEN--MTDFAVFENLTTIRGRVLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYYNTIKWPAVFVSEQQTSYVHDNKPEADCNADGAVCDLLCS-EHGCWGPGPDQCISCRFFR--RARSCVESCYITEGPY--REHMQ--DAVCAPCDPECLPVNDSVTCFGPGSNSCVR-CAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNCS 484 HSP 2 Score: 107.071 bits (266), Expect = 1.379e-23 Identity = 94/424 (22.17%), Postives = 162/424 (38.21%), Query Frame = 2
Query: 2666 WIDRQANHEYQFGAICLPCHPLCSQCSDGTI------ESCHRCKSHRRGKECVHNCY-----EDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFR--IFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
+I E+ A+C PC P C +D SC RC ++ G CV C E+D I + + C CH C GC G DC + L + + G F + + +VCV+ + + RKR ++ S AP+ +L + E + +L G F + KG WT + + V + V IKVL E + NK+ L + I+ S P +R++ + + +L QL G L+E+ +++ + +L WA Q+A G Y++ + +++ D+ N+ + +P + I+D GL++L + GK+ I W E+ + F+ +S V +Y
Sbjct: 399 YITEGPYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNCSHGCKGGGLLDC----HLIGPLFRTGSPVLAVMAVGGLFACVMLLLLAVVCVRRRNIA----------------------------------RKRA-MRRYIEKELVEPLTPSGAAPNQAQLRILKETELRKGKMLGSGAFGTVHKGIWTPEGED--------------------VKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQLVTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLDINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYG 763
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 174.866 bits (442), Expect = 1.456e-44 Identity = 160/611 (26.19%), Postives = 266/611 (43.54%), Query Frame = 2
Query: 632 NLNKNCTHVIGNVIITGITN-ENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENM--LKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEK--FTFHNTCVDKCPDKYF-IENEKCVPKCKNGATYAVNET----CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKL--TNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSIL--HSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSN--ITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS--------TSNICKACHQSCTK 2389
++ NC V+GN+ IT I N +LSFL +I E++G++ + N V+ + L+NL+++RG + R L+ ++ + E LK L L + IL+ + V PG+ W+ I ++ P + +F+S + CH SC K FCWG+ CQ + K C +C YG L QCCH+ C GC GP T C + ++ + + L + + + + V P F ++ CV C T + + C PCP+ +CPK C + Q ++ K + NCT GN+I + NG+ N + G ++ +L+++ GSL +N W + L + +L++ + L L ++++ L+F+ ++ V++ V +P C+ +L S+ SN + + GK E C LC + GCWGP M C+ C+ + C+ +CS G E C CH +C+ N +TC+GPG D CT C NY+ +C CP+ G+ +C CH +CT+
Sbjct: 23 SMYTNCEVVMGNLEITYIRNGSDLSFLRTIREVSGYVLIALNEVDHVPLENLRVVRGTRLYDQRYALTVLLNYNDSVPEERLGLKELRLTRLTEILRGGVYVRKEPGL------PSWDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSC-----KNFCWGSGPQYCQTFTSTICAKQC--DGRC--YG-LDPNQCCHKHCASGCTGPRETDCFPASSWRSRASIQDNVLCGLFFSVTIYQFDNPPRGNLALRQALVADFPAGNFVVDYNSCVRSCPVNKTEVEDGSGVKHCKPCPDNLCPKVCDGIGSGKLKEAQTVDAKNIHFFSNCTTISGNLIF--------LRNGFDGNCHFQNGIHVKPRCCQSLQQLTGSLLLN-HYPVRW-QVLPFLLHLDLSKPSRKQFWRLHVLLVHKS--LLFMLMRYCTYVKSFQVTATVHPIFCFVSTLFGSSLYSTKSNGRHCCACDRPGK-EGYVCDALCSAE-GCWGPGPMQCLSCKFHK--RGKTCVESCSVLDG----DEREFVSGALCIACHAECMLINGSLTCHGPGPDNCT-RCRNYREGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQ 596 HSP 2 Score: 67.0106 bits (162), Expect = 3.215e-11 Identity = 50/227 (22.03%), Postives = 99/227 (43.61%), Query Frame = 2
Query: 3218 SDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
S P+ +L + E + +L G F + KG W + E V + V +KVL + + NKD L + ++ S D P +R++ + + + ++L QL G L+E+++++ V IL W Q+A I+ ++ D+ + + +P RI ++ + L + + + K + + I W E+ + F+ +S V +Y
Sbjct: 669 SGAQPNQAQLRILKETELKKGKVLGSGAFGTVYKGIWVPEG--------------------ESVKIAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQLVTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVRLVMSLRTPPRITLASANLFQ---SIDDAKHWHDRDMPIKWMALESIQYRKFTHQSDVWSYG 872
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002120.1 (pep scaffold:Pmarinus_7.0:GL478472:36400:43944:-1 gene:ENSPMAG00000001922.1 transcript:ENSPMAT00000002120.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 103.99 bits (258), Expect = 4.192e-24 Identity = 93/344 (27.03%), Postives = 148/344 (43.02%), Query Frame = 2
Query: 1409 YFIENEKCVPKCKNGATYAVNET----CLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPK-NIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSL--TNKSILHSNQMNIYNNGKDGKCEA--RKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCL--SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTS--------NICKACHQSC 2383
+ +++ CV C N + C C + CP C Q +N + +NCT GN++I I GD P I + + L ++EI G N+ L L F NL +++ + I+ +++ L L+ L+E+ G + I N KLC+ +S+ T + S + I +N K+ +C ++C LC GCWGP C+ C+HFQ C+ C+ + + T C C+ +CL ++N+TC GPG++ C+ C N+K C KCP G+ +T NIC CH SC
Sbjct: 2 FVVDSNSCVRSCSANKMEVENSSGVKHCTACGD-TCPTVCDGIGSGSLKESQTINSANIHLFQNCTKIRGNLVIQKPGINGD-----PYLRIERMNPEHLNYFRTVQEITGYF--NIEGWPEELPDLGVFENLRVVQGRELRSSKEYSFLISNLNNITSLNLKSLQEISKGNILIQQNKKLCFYNSVNWTRLTGSTSTLIKIVDNNKNCECYCLNKQCDVLCSTD-GCWGPGPSQCLACKHFQ--RNRTCVEACN----LMHGEVREFTDGNMCKACNPECLPVNNNLTCNGPGSENCS-ACRNFKEGPLCVSKCPSGIQGENNTVIYKYPNAFNICMPCHTSC 329 HSP 2 Score: 63.1586 bits (152), Expect = 1.563e-10 Identity = 69/289 (23.88%), Postives = 124/289 (42.91%), Query Frame = 2
Query: 635 LNKNCTHVIGNVII--TGITN-----------ENLSFLNSIEEITGFLFLFSNSVESISL---KNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGK-HQFLEIVEPH-NSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELK------IEQCCHEECVG-----GCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTF----HNTCVDKCP 1402
L +NCT + GN++I GI E+L++ +++EITG+ + E L +NL++++G +E F ++SN+ N + L L Q I + NIL+ N + ++ N+++W + G ++IV+ + N + + D+ C + CWG QC R + + ++GE++ + + C+ EC+ C GP + C C++F CV KCP + I F H +C+ CP
Sbjct: 61 LFQNCTKIRGNLVIQKPGINGDPYLRIERMNPEHLNYFRTVQEITGYFNIEGWPEELPDLGVFENLRVVQGRELRSSKEYSF---LISNL---NNITSLNLKSLQEISKGNILIQQNKKLCFY-NSVNWTRLTGSTSTLIKIVDNNKNCECYCLNKQCDVLCSTD--------GCWGPGPSQCLACKHFQRNRTCVEACNLMHGEVREFTDGNMCKACNPECLPVNNNLTCNGPGSENCSACRNFKEGPLCVSKCPSGIQGENNTVIYKYPNAFNICMPCHTSCIHSCP 334
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008321.1 (pep scaffold:Pmarinus_7.0:GL483972:456:13241:-1 gene:ENSPMAG00000007528.1 transcript:ENSPMAT00000008321.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 99.3673 bits (246), Expect = 7.337e-23 Identity = 83/302 (27.48%), Postives = 130/302 (43.05%), Query Frame = 2
Query: 1271 CKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIK--DVVQNYNI---QYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMN--IYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNC 2143
CK+FN+ GACV CP +++N V +N K+++ CV +CP + ++ CV C G + C + C + C K D + N+ Q ++ + ENCT +GNI I+GD P ++ + L ++KE+ G L I + + F NL IR L + + + LGL L E+ G V + N +LCY +++ S+ S + I++N C E C LC GCWGP C+ CR F + C+ C
Sbjct: 2 CKNFNDSGACVSHCPPPMIYNPVSFQLEENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKQGKKKCES--CTRICPTKACDGIGTGNLSHAQTVDASNIDTFENCTKINGNIAFLVTGIKGDSYMKIPP----LEPEKLNVFRSVKEVTGYLMIQAWPQN--MTDFGVFENLTTIRGRVLQRGF--SLLVARIPTVTALGLASLHEISAGNVYLKQNERLCYYNTINWTSVFMSERQTPFIHDNKPPPNCTSEGMLCDPLCS-NDGCWGPGPDQCISCRFF--SRGRACVEAC 290
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO31298 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYB5]) HSP 1 Score: 53.9138 bits (128), Expect = 1.526e-7 Identity = 46/179 (25.70%), Postives = 84/179 (46.93%), Query Frame = 2
Query: 3410 GLNVTIKVLSECSDLADNK--DFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSK-LSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN----SDHDTRP 3925
G + + V S SD +N + L + +++ D P+ +RII + L +L G L ++LK+N + ++IL+ QVA G Y++ ++ D+ N+ + + + ISD G+S+ + + K G+ + W E + FSSKS V +Y + + RP
Sbjct: 50 GERIPVAVKSLKSDDINNPKSEILHEARVMMELDHPYIVRIIGMCQGPSMMLVMELAGEGPLNKYLKKNKGM-PLLNILVLMLQVAEGMQYLESLQFVHRDLAARNVLVVNDSFVKISDFGMSRAMGAGSDYYKAGTAGRWPLKWYAPECIYFRKFSSKSDVWSYGITLWEATSYGARP 227
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 53.5286 bits (127), Expect = 4.222e-7 Identity = 54/210 (25.71%), Postives = 89/210 (42.38%), Query Frame = 2
Query: 3278 EHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITST-DPPWNLRIILVVVCAYSELS--KQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
E ++ G+F + KGT + NT IP V IK L + S + DFL + ++ DP N+ + VV L + + GSL FLK+ S + I ++ A +ASG Y+ ++ D+ NI + L ++D GLS+ + + GK+ + W+ E + FS+ S V +Y
Sbjct: 61 EKVIGGGEFGDVYKGTLKRPGENT--------------IP-------VAIKTLKQGSTSKNRGDFLSEASVMGQFCDP--NVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLKKMDSKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSR--ELEDSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYG 245
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO33731 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD2]) HSP 1 Score: 51.9878 bits (123), Expect = 6.395e-7 Identity = 43/167 (25.75%), Postives = 75/167 (44.91%), Query Frame = 2
Query: 3419 VTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELS--KQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSK-LSNTCNRMK---KIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNC 3901
V +K+L S + +DF + I+ D P N+ + V+ + + GSL FLK N + + ++ VA+G Y+ I+ D+ NI + L +SD GLS+ L ++ + + + GK+ + W+ E + FSS S V +Y
Sbjct: 59 VAVKILKPGSSHKNREDFCVEASIMGQFDHP-NVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGI 224
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO33732 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD3]) HSP 1 Score: 51.9878 bits (123), Expect = 6.756e-7 Identity = 43/167 (25.75%), Postives = 75/167 (44.91%), Query Frame = 2
Query: 3419 VTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELS--KQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSK-LSNTCNRMK---KIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNC 3901
V +K+L S + +DF + I+ D P N+ + V+ + + GSL FLK N + + ++ VA+G Y+ I+ D+ NI + L +SD GLS+ L ++ + + + GK+ + W+ E + FSS S V +Y
Sbjct: 57 VAVKILKPGSSHKNREDFCVEASIMGQFDHP-NVIALKGVITRTRPMMIITEFLENGSLENFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGI 222
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 52.373 bits (124), Expect = 8.160e-7 Identity = 43/167 (25.75%), Postives = 75/167 (44.91%), Query Frame = 2
Query: 3419 VTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELS--KQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSK-LSNTCNRMK---KIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNC 3901
V +K+L S + +DF + I+ D P N+ + V+ + + GSL FLK N + + ++ VA+G Y+ I+ D+ NI + L +SD GLS+ L ++ + + + GK+ + W+ E + FSS S V +Y
Sbjct: 56 VAVKILKPGSSHKNREDFCVEASIMGQFDHP-NVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGI 221
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 246.514 bits (628), Expect = 1.190e-65 Identity = 195/629 (31.00%), Postives = 297/629 (47.22%), Query Frame = 2
Query: 620 KVTANLNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKL---TNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH--SNQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQCL---SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTG 2425
+ L +NC V+GN+ IT I N NLSFL SI E+TG++ + N E + L+NL+IIRG + E +++L + N G LK L L IL + V N L + IHW ++ Q +V P N+SN + CH SC G+ CWG+ QCQ + V + C +CF + CCH EC GGC+GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV +CP + +++ CV C + + C+PC + +CPK C Q ++ + + NCT +GN+I I+GD+ +GI D E+L +KEI G L N+ S + L F NL I + + L I + + Q L E+ G V I NN +LC+ +++ S+ S ++ I NN + +C ++ C ++C + GCWGP C+ CR+F+ C+ +C+ +N E + + C +C +QC +++TC G G DQC C+N+K C EKCP G S +N C CH +CT+ + + C G
Sbjct: 137 RTLRKLYENCEVVMGNLEITSIDRNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGTTLY---EGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQN-KFLCHADTIHWQDVIKNPQAELLVVPSNNSNNGCRR-----CHRSCN---GR--CWGHQEDQCQTLTKTVCAEQC--DGRCF---GPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCTD-ICPKVCDGIGTGSLQTAQTVDASNIDKFVNCTKINGNLIFLITGIKGDM-------YHGIGPLDPERLNVFRTVKEITGFL--NIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMCS-EDGCWGPGPDQCLSCRYFK--RGRTCVESCN-----LFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCV-KCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVG 727 HSP 2 Score: 98.5969 bits (244), Expect = 3.362e-20 Identity = 91/416 (21.88%), Postives = 161/416 (38.70%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
E+ G++CL C C + ++ + C +C + + G CV C D NS + A + C CH C +GC G DC +T I G F I + + V + + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L + + GK+ I W E + + F+ +S V +Y
Sbjct: 636 REFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKC-PDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMM--------DRTPLIAAGIIGGLFIIVIVALTVAIYARR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYG 989
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 246.128 bits (627), Expect = 1.523e-65 Identity = 194/624 (31.09%), Postives = 295/624 (47.28%), Query Frame = 2
Query: 635 LNKNCTHVIGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKL---TNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH--SNQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQCL---SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTG 2425
L +NC V+GN+ IT I N NLSFL SI E+TG++ + N E + L+NL+IIRG + E +++L + N G LK L L IL + V N L + IHW ++ Q +V P N+SN + CH SC CWG+ QCQ + V + C +CF + CCH EC GGC+GP +T C C +FN+ GACV +CP+ V+N + N K+T+ CV +CP + +++ CV C + + C+PC + +CPK C Q ++ + + NCT +GN+I I+GD+ +GI D E+L +KEI G L N+ S + L F NL I + + L I + + Q L E+ G V I NN +LC+ +++ S+ S ++ I NN + +C ++ C ++C + GCWGP C+ CR+F+ C+ +C+ +N E + + C +C +QC +++TC G G DQC C+N+K C EKCP G S +N C CH +CT+ + + C G
Sbjct: 142 LYENCEVVMGNLEITSIDRNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGTTLY---EGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQN-KFLCHADTIHWQDVIKNPQAELLVVPSNNSNNGCRR-----CHRSCNGR-----CWGHQEDQCQTLTKTVCAEQC--DGRCF---GPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCTD-ICPKVCDGIGTGSLQTAQTVDASNIDKFVNCTKINGNLIFLITGIKGDM-------YHGIGPLDPERLNVFRTVKEITGFL--NIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMCS-EDGCWGPGPDQCLSCRYFK--RGRTCVESCN-----LFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCV-KCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVG 727 HSP 2 Score: 98.9821 bits (245), Expect = 3.041e-20 Identity = 91/416 (21.88%), Postives = 161/416 (38.70%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
E+ G++CL C C + ++ + C +C + + G CV C D NS + A + C CH C +GC G DC +T I G F I + + V + + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L + + GK+ I W E + + F+ +S V +Y
Sbjct: 636 REFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKC-PDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMM--------DRTPLIAAGIIGGLFIIVIVALTVAIYARR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYG 989
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 239.965 bits (611), Expect = 8.956e-64 Identity = 191/616 (31.01%), Postives = 291/616 (47.24%), Query Frame = 2
Query: 659 IGNVIITGI-TNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCV-RKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHI--KNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVN---ETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLT---NLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILH--SNQMNIYNNGKDGKCEARK--CSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQ-THEMQCSKCHNQCL---SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGS-------TSNICKACHQSCTKENLFSFKRTCTG 2425
+GN+ IT I N NLSFL SI E+TG++ + N E + L+NL+IIRG + E +++L + N G LK L L IL + V N L + IHW ++ Q +V P N+SN + CH SC G+ CWG+ QCQ + V + C +CF + CCH EC GGC+GP +T C C +FN+ GACV +CP+ V+N N K+T+ CV +CP + +++ CV C + + C+PC + +CPK C Q ++ + + NCT +GN+I I+GD+ +GI D E+L +KEI G L N+ S + L F NL I + + L I + + Q L E+ G V I NN +LC+ +++ S+ S ++ I NN + +C ++ C ++C + GCWGP C+ CR+F+ C+ +C+ +N E + + C +C +QC +++TC G G DQC C+N+K C EKCP G S +N C CH +CT+ + + C G
Sbjct: 1 MGNLEITSIDRNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGTTLY---EGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQN-KFLCHADTIHWQDVIKNPQAELLVVPSNNSNNGCRR-----CHRSCN---GR--CWGHQEDQCQTLTKTVCAEQC--DGRCF---GPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECPHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCTD-ICPKVCDGIGTGSLQTAQTVDASNIDKFVNCTKINGNLIFLITGIKGDM-------YHGIGPLDPERLNVFRTVKEITGFL--NIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPMECLQQQMICDRMCS-EDGCWGPGPDQCLSCRYFK--RGRTCVESCN-----LFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCV-KCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVG 578 HSP 2 Score: 98.9821 bits (245), Expect = 3.002e-20 Identity = 91/416 (21.88%), Postives = 161/416 (38.70%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLCSQCSDGTI-------ESCHRCKSHRRGKECVHNCYEDDYISKNS-----SNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYN 3898
E+ G++CL C C + ++ + C +C + + G CV C D NS + A + C CH C +GC G DC +T I G F I + + V + + K I +K+ L+ S AP+ +L + E + IL G F + KG W + E V + V IK+L+E + N +F+ + I+ S + P +R++ V + +L QL G L++++ ++ + +L W Q+A G Y++ +++ D+ N+ ++SP I I+D GL++L + + GK+ I W E + + F+ +S V +Y
Sbjct: 487 REFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKC-PDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMM--------DRTPLIAAGIIGGLFIIVIVALTVAIYARR---------------------------KSI------KKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKILGSGAFGTVYKGIWVPEG--------------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYG 840
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: erbb3a (erb-b2 receptor tyrosine kinase 3 [Source:NCBI gene;Acc:101172402]) HSP 1 Score: 237.654 bits (605), Expect = 6.431e-63 Identity = 199/683 (29.14%), Postives = 308/683 (45.10%), Query Frame = 2
Query: 611 NYMKVTANLNKNCTHVIGNVIITGIT-NENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNII--GENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDL-SCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHN--GVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE---TCLPCPNGVCPKDC-----LIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTN---NKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQ-------MNIYNNGKDGKC--EARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQC--LSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGD-------GSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFIS----RFTVHSLTCIH 2542
N MK ++ NC V+GN+ IT + N + SFL SI+E+TG++ N + L L++IRG + E +++L V+ N G++ L+ L L + IL+ + + N L + ++W I+ + S++ +E G + CH SC+ CWG S +CQI+ V + +S+CF +CCH EC GGC GPL+T C CK+FNN G+CV +CP+ L++N + N K+ + + CV +CP + ++ CV C + + C PC G+CPK C ++ V +NI NCT G++ IEGD NG P + + L+ ++EI L I S L L F NL +I+ T +K L + + L LG + L++V +G+V I N KLCY D++ I+++ + + N +C E C LC GCWGP CV C+++ + C+ +C G + T +C CH+QC TC GPGA +C C N K +C CPQ G+ + C+ CH +CT+ CTGP V + Q T G I+ F+V +LT ++
Sbjct: 50 NQMK---SMYTNCNIVMGNLEITMMEHNRDYSFLQSIKEVTGYVLFAVNQFSRLPLDQLRVIRGNTLY---EDQYALAVMLNYQKNGQHGLQELGLTQLTEILRGGVKIIQN-KFLSYAPQVNWQDIVK----------NGSAHIMIEENGPIKPCHESCK----DVPCWGPGSDKCQILTHTVCAP-QCNSRCF---GTNPNECCHTECAGGCRGPLDTDCFACKNFNNLGSCVPQCPQALIYNKHAFRMEPNPDAKYQYGSFCVSECPANFLVDGSSCVSSCPSDKKEVEKDGVKRCDPC-GGLCPKACHGTGSPGRETVDAHNID--------SFMNCTKIQGSLHFLITGIEGDEYNGIPP----LNPEKLKIFKTVEEITDYLSIQ--SWPDSLSNLSVFSNLRVIQGRTLYKGVSKRGYSLMVMKIKSLSSLGFRSLQKVNDGVVYITGNKKLCYQDTVNWTRIVNNRPRQKRQKFVEVKENRPSKECVEEGHVCDPLCSAD-GCWGPGPDQCVSCKNY--SRGGTCVPDCMFLSGV---QREFVTSTKECQLCHSQCQIQEGRTTCTGPGAHECV-ACANLKDGPHCVSSCPQGVMGEEGIVFKYSDKNRNCEQCHINCTE--------GCTGPALENCVGASTRAISRQATTGIVLGLIAFIFVSFSVMTLTFLY 677
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Match: ENSORLT00000004469.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984]) HSP 1 Score: 234.572 bits (597), Expect = 2.498e-62 Identity = 195/633 (30.81%), Postives = 289/633 (45.66%), Query Frame = 2
Query: 644 NCTHVIGNVIIT-GITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENM---------LKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLV--HNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNE----TCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETT-NNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCL--SSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGD--------GSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRK 2461
NC+ V+ N+ IT + N++LSFL SI+E+ G++ + N V ++ L NL++IRG+N +Y KF+L+V+SN N+ L+ L L + IL + V NNP +L I W I+ K + ++ + + C P CW CQ V +C K CC++ C GC GPL T CL CK+FN+ G C + CP + H + ++N K++F TCV CP Y + CV C TY V E C C G CPK C V + N +N + NCT +G+I+ S GD NI + K LE +KEI G L I + + +L F NLEIIR + NK+ + D+L +LGL+ LKE+ G V + +N LCY+ ++ N S L ++ I D + C + C K GCWGP C+ C++F K C+ C+ G + E C +CH +CL + TC+GPG DQC+ C ++K +C CP D + C+ CHQ+C++ C+GP G++GC +
Sbjct: 69 NCSVVLENLEITYTLENQDLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQN--LYD--KFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGVKVTNNP-LLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDCER---------CDPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRC---SGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYSFGATCVKACPHNYVVTEGSCVRACSPN-TYEVEENGVQRCKRC-EGPCPKACDGVGVGRLTNTIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQH----YNIPPMDPKKLEYFRTVKEITGHLLIQTWPEN--MTSLSVFENLEIIRGRSLFVNKY--SFVVVGADNLHWLGLRSLKELSAGNVRLKDNKLLCYSKAM-NWSYLFRDKTQIV----DQTPPNQTCDQQCSSK-GCWGPGTNMCLSCQYF--NRKQHCVERCNLLQG----EPREVEVEGSCVECHPECLVMTGTQTCHGPGPDQCS-QCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQ--------GCSGP----GLSGCSR 649 HSP 2 Score: 90.5077 bits (223), Expect = 9.305e-18 Identity = 87/414 (21.01%), Postives = 157/414 (37.92%), Query Frame = 2
Query: 2687 HEYQFGAICLPCHPLC------SQCSDGTIESCHRCKSHRRGKECVHNCY-----EDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTY 3895
E + C+ CHP C C + C +C + G CV C +++ + ++ C CH+ C +GC+G C R + +S + +FV +V V+ Q +K +KR +L S AP+ L + E + +L G F + KG W + N V + V IKVL E + N++ L + ++ S D P R++ + + + +L QL G L+++++Q+ + +L W Q+A G Y++ +++ D+ N+ +++P I I+D GL+KL + GK+ I W E+ ++ +S V +Y
Sbjct: 558 REVEVEGSCVECHPECLVMTGTQTCHGPGPDQCSQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQGCSGP---GLSGCSRTTTH-SSLAVGVVSGLLVAVIVLLFV---LVYVRRQRIK----------------------------------KKRTLRRLLQEKELVEPLTPSGQAPNQALLRILKETEFKKVRVLGSGAFGTVFKGLWVPEGEN--------------------VRIPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLTSSVQLVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTYTHQSDVWSY 910
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044602.1 (SMESG000044602.1) HSP 1 Score: 2482.6 bits (6433), Expect = 0.000e+0 Identity = 1244/1266 (98.26%), Postives = 1254/1266 (99.05%), Query Frame = 2
Query: 401 KPNPNHHKEINGNDSLVKINVSNFDRQASEFNLKTNNASSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKNSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHDTRPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIYHVESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN 4198
KPNPNHHKEINGN SLVKINVSNFDRQASEFNLKTN SSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNK CTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNI+WNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGS APWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCE+RKCSKLCHPKYGCWGPLGMFCVKCR+FQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYG GADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMSLLKLYSNNSSLKMVLENW+DRQANHEYQFGAICLPCHPLCSQCSDGTIESC RCK HRRGKECVHNCYEDDYISK+SSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQEL IQNSWYIAAVGGSVVSVLAVGIVWKCIC+SLNKRKRYDLKLKF NGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLG+FCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPD+LVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTC+RMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHD RPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIY+VESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN
Sbjct: 18 KPNPNHHKEINGNYSLVKINVSNFDRQASEFNLKTNYGSSDSFRRADSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKKCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNINWNSILGKHQFLEIVEPHNSSNFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSNAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCESRKCSKLCHPKYGCWGPLGMFCVKCRNFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGTGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMSLLKLYSNNSSLKMVLENWVDRQANHEYQFGAICLPCHPLCSQCSDGTIESCRRCKYHRRGKECVHNCYEDDYISKHSSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELTLIQNSWYIAAVGGSVVSVLAVGIVWKCICVSLNKRKRYDLKLKFPNGFSTVDIESDFAPSSTKLLPIAEGQPANEHILDLGRFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDKLVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCSRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCNSDHDARPNLRKLKQSIEMIMKNPCSFIILQINRDMSERQITVVNGLHSQIIYNVESSESKLQNEDLITTFNNHLEVPDESLRNPTSHHEDIVNNLILN 1283
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1) HSP 1 Score: 882.478 bits (2279), Expect = 0.000e+0 Identity = 484/1205 (40.17%), Postives = 700/1205 (58.09%), Query Frame = 2
Query: 539 DSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSS-NFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKN-SSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD--IESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN-------------------------------------------------SDHDTRPNLRKLKQSIEMIMKNPCSFIILQ 3994
D H C S D+ N+Y + N +KNC+++IG+V+I ITNEN+SFLNSIE+I+G+L +FSN+VESISL LK+IRGENP + + +KFSL+V N +ML+ ++ P QVIL+HN+ NNP + Y I+WNS++ + Q + IVE + SK +LSCH SCQ H+ K +CWGNSS CQ INDC +TC S+KC++ LK E+CCHEECVGGC GP +QCL CK+FNN G CVE CP + H+G+K+I+N L K F+ CVDKCP K+F E+ CV +C TYAVN+TC+PCPNG CPK C +D++ + I Y++RK+L RLENCTVY GNI+IN S+EGD + K GI+ +DL+KL NL+EIYG L I+V + W +L + +NL IIRAE + G+ I N L +LGL+ LKEVRNG + I +N +LC++++LTNKSILH NGK G C +KC C + GCWGP CVKC+ F I E C+S CS +PGYFYN + CS+CH++CL TC+G ++C GC NYK+ + C +KCP +Y D + C CH +CT EN + + C GP + +G GC CN++ + +N S + + + L C+ +S+ C G++K +DF S + + S +LE WI+ NH+ ++C PCHP CS+C G+ C CK R +C+ C ++ +I+ N ++ ES C KCHEEC EGC GST YDC +CK KIY+N S T+FFCNS CGD ++F SE++C L + + YI G + + + V I+ I S N+ K++ KL F D S P+ LL I E Q + I+ G F I+ KG W + + S K + KI D + LNV +K+L++ SD ++N++ L++ K++ S D P LRI+ V + A+ +L Q GSL+EF+++N S++ I++L+WA Q+ASG Y++ +GII+ D+ N+ I+SP ++ I+D GL+K+ + + + K G++ I W E ++ FSSKS V +Y D D RP+ +L+++ EM+ NP ++++Q
Sbjct: 67 DKRYRHGKVCKSTQTQIDV--SKNSYESLKRNFDKNCSYIIGDVVIAHITNENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQEVVIVETNEKDCGLNSKIDEELSCHESCQAHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILKTEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPKICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYYVDSMKN--CYPCHTNCT-ENSQNKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKV------NAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWHCSLCKYFRSDNKCIQKCPKEYFITVNETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGS-TQFFCNSTCGDRIQLFQTSEIICT--DHLIYSRFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQ 1253
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1) HSP 1 Score: 882.478 bits (2279), Expect = 0.000e+0 Identity = 484/1205 (40.17%), Postives = 700/1205 (58.09%), Query Frame = 2
Query: 539 DSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSS-NFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKN-SSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGF--STVDIESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN-------------------------------------------------SDHDTRPNLRKLKQSIEMIMKNPCSFIILQ 3994
D H C S D+ N+Y + N +KNC+++IG+V+I ITNEN+SFLNSIE+I+G+L +FSN+VESISL LK+IRGENP + + +KFSL+V N +ML+ ++ P QVIL+HN+ NNP + Y I+WNS++ + Q + IVE + SK +LSCH SCQ H+ K +CWGNSS CQ INDC +TC S+KC++ LK E+CCHEECVGGC GP +QCL CK+FNN G CVE CP + H+G+K+I+N L K F+ CVDKCP K+F E+ CV +C TYAVN+TC+PCPNG CPK C +D++ + I Y++RK+L RLENCTVY GNI+IN S+EGD + K GI+ +DL+KL NL+EIYG L I+V + W +L + +NL IIRAE + G+ I N L +LGL+ LKEVRNG + I +N +LC++++LTNKSILH NGK G C +KC C + GCWGP CVKC+ F I E C+S CS +PGYFYN + CS+CH++CL TC+G ++C GC NYK+ + C +KCP +Y D + C CH +CT EN + + C GP + +G GC CN++ + +N S + + + L C+ +S+ C G++K +DF S + + S +LE WI+ NH+ ++C PCHP CS+C G+ C CK R +C+ C ++ +I+ N ++ ES C KCHEEC EGC GST YDC +CK KIY+N S T+FFCNS CGD ++F SE++C L + + YI G + + + V I+ I S N+ K++ KL F S S P+ LL I E Q + I+ G F I+ KG W + + S K + KI D + LNV +K+L++ SD ++N++ L++ K++ S D P LRI+ V + A+ +L Q GSL+EF+++N S++ I++L+WA Q+ASG Y++ +GII+ D+ N+ I+SP ++ I+D GL+K+ + + + K G++ I W E ++ FSSKS V +Y D D RP+ +L+++ EM+ NP ++++Q
Sbjct: 70 DKRYRHGKVCKSTQTQIDV--SKNSYESLKRNFDKNCSYIIGDVVIAHITNENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQEVVIVETNEKDCGLNSKIDEELSCHESCQAHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILKTEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPKICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYYVDSMKN--CYPCHTNCT-ENSQNKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKV------NAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWHCSLCKYFRSDNKCIQKCPKEYFITVNETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGS-TQFFCNSTCGDRIQLFQTSEIICT--DHLIYSRFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQ 1256
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1) HSP 1 Score: 882.478 bits (2279), Expect = 0.000e+0 Identity = 484/1205 (40.17%), Postives = 700/1205 (58.09%), Query Frame = 2
Query: 539 DSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSS-NFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKN-SSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD--IESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN-------------------------------------------------SDHDTRPNLRKLKQSIEMIMKNPCSFIILQ 3994
D H C S D+ N+Y + N +KNC+++IG+V+I ITNEN+SFLNSIE+I+G+L +FSN+VESISL LK+IRGENP + + +KFSL+V N +ML+ ++ P QVIL+HN+ NNP + Y I+WNS++ + Q + IVE + SK +LSCH SCQ H+ K +CWGNSS CQ INDC +TC S+KC++ LK E+CCHEECVGGC GP +QCL CK+FNN G CVE CP + H+G+K+I+N L K F+ CVDKCP K+F E+ CV +C TYAVN+TC+PCPNG CPK C +D++ + I Y++RK+L RLENCTVY GNI+IN S+EGD + K GI+ +DL+KL NL+EIYG L I+V + W +L + +NL IIRAE + G+ I N L +LGL+ LKEVRNG + I +N +LC++++LTNKSILH NGK G C +KC C + GCWGP CVKC+ F I E C+S CS +PGYFYN + CS+CH++CL TC+G ++C GC NYK+ + C +KCP +Y D + C CH +CT EN + + C GP + +G GC CN++ + +N S + + + L C+ +S+ C G++K +DF S + + S +LE WI+ NH+ ++C PCHP CS+C G+ C CK R +C+ C ++ +I+ N ++ ES C KCHEEC EGC GST YDC +CK KIY+N S T+FFCNS CGD ++F SE++C L + + YI G + + + V I+ I S N+ K++ KL F D S P+ LL I E Q + I+ G F I+ KG W + + S K + KI D + LNV +K+L++ SD ++N++ L++ K++ S D P LRI+ V + A+ +L Q GSL+EF+++N S++ I++L+WA Q+ASG Y++ +GII+ D+ N+ I+SP ++ I+D GL+K+ + + + K G++ I W E ++ FSSKS V +Y D D RP+ +L+++ EM+ NP ++++Q
Sbjct: 82 DKRYRHGKVCKSTQTQIDV--SKNSYESLKRNFDKNCSYIIGDVVIAHITNENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQEVVIVETNEKDCGLNSKIDEELSCHESCQAHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILKTEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPKICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYYVDSMKN--CYPCHTNCT-ENSQNKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKV------NAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWHCSLCKYFRSDNKCIQKCPKEYFITVNETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGS-TQFFCNSTCGDRIQLFQTSEIICT--DHLIYSRFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQ 1268
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1) HSP 1 Score: 881.322 bits (2276), Expect = 0.000e+0 Identity = 484/1205 (40.17%), Postives = 700/1205 (58.09%), Query Frame = 2
Query: 539 DSHSDHQNTCISKLVYEDIRDKPNNYMKVTANLNKNCTHVIGNVIITGITNENLSFLNSIEEITGFLFLFSNSVESISLKNLKIIRGENPWIYREVKFSLVVVSNIIGENMLKYLILPKFQVILQHNILVYNNPGMLYFKNNIHWNSILGKHQFLEIVEPHNSS-NFTSKEIGDLSCHSSCQPHMGKRFCWGNSSGQCQIINDCVRKTCKLSSKCFLYGELKIEQCCHEECVGGCYGPLNTQCLICKHFNNQGACVEKCPRKLVHNGVKHIKNRLEKFTFHNTCVDKCPDKYFIENEKCVPKCKNGATYAVNETCLPCPNGVCPKDCLIKDVVQNYNIQYLNRKMLARLENCTVYHGNIIINTLSIEGDIGNGWPKNIYGIQGKDLEKLTNLKEIYGSLEINVGSKAPWLKTLLYFRNLEIIRAETTNNKHLTGLSINQNDDLVFLGLQELKEVRNGIVEIVNNPKLCYTDSLTNKSILHSNQMNIYNNGKDGKCEARKCSKLCHPKYGCWGPLGMFCVKCRHFQITEKNMCISNCSKQPGYFYNKENHQTHEMQCSKCHNQCLSSNITCYGPGADQCTFGCVNYKYNDYCTEKCPQDHYGDGSTSNICKACHQSCTKENLFSFKRTCTGPGNHIGVNGCRKCNYVQLLTNGSEGFISRFTVHSLTCIHSSNNCLDGYFKISLDFHSPENIMXXXXXXXXXXXXXMVLENWIDRQANHEYQFGAICLPCHPLCSQCSDGTIESCHRCKSHRRGKECVHNCYEDDYISKN-SSNAESLCLKCHEECMEGCTGSTEYDCKQCKRVKIYLNSSKTKFFCNSICGDNFRIFVNSEMVCVQPQELKPIQNSWYXXXXXXXXXXXXXXXXXWKCICMSLNKRKRYDLKLKFSNGFSTVD--IESDFAPSSTKLLPIAEGQPANEHILDLGKFCIMDKGTWTQKSNNTNCKKSCFKECLFKIIPDELVGLNVTIKVLSECSDLADNKDFLQKLKIITSTDPPWNLRIILVVVCAYSELSKQLTTTGSLIEFLKQNPSVVEDISILLWAHQVASGFGYIKYEGIINYDVETSNIKIESPLRIAISDSGLSKLSNTCNRMKKIKEGKLGIIWSLKENCNDQGFSSKSSVMTYNCN-------------------------------------------------SDHDTRPNLRKLKQSIEMIMKNPCSFIILQ 3994
D H C S D+ N+Y + N +KNC+++IG+V+I ITNEN+SFLNSIE+I+G+L +FSN+VESISL LK+IRGENP + + +KFSL+V N +ML+ ++ P QVIL+HN+ NNP + Y I+WNS++ + Q + IVE + SK +LSCH SCQ H+ K +CWGNSS CQ INDC +TC S+KC++ LK E+CCHEECVGGC GP +QCL CK+FNN G CVE CP + H+G+K+I+N L K F+ CVDKCP K+F E+ CV +C TYAVN+TC+PCPNG CPK C +D++ + I Y++RK+L RLENCTVY GNI+IN S+EGD + K GI+ +DL+KL NL+EIYG L I+V + W +L + +NL IIRAE + G+ I N L +LGL+ LKEVRNG + I +N +LC++++LTNKSILH NGK G C +KC C + GCWGP CVKC+ F I E C+S CS +PGYFYN + CS+CH++CL TC+G ++C GC NYK+ + C +KCP +Y D + C CH +CT EN + + C GP + +G GC CN++ + +N S + + + L C+ +S+ C G++K +DF S + + S +LE WI+ NH+ ++C PCHP CS+C G+ C CK R +C+ C ++ +I+ N ++ ES C KCHEEC EGC GST YDC +CK KIY+N S T+FFCNS CGD ++F SE++C L + + YI G + + + V I+ I S N+ K++ KL F D S P+ LL I E Q + I+ G F I+ KG W + + S K + KI D + LNV +K+L++ SD ++N++ L++ K++ S D P LRI+ V + A+ +L Q GSL+EF+++N S++ I++L+WA Q+ASG Y++ +GII+ D+ N+ I+SP ++ I+D GL+K+ + + + K G++ I W E ++ FSSKS V +Y D D RP+ +L+++ EM+ NP ++++Q
Sbjct: 47 DKRYRHGKVCKSTQTQIDV--SKNSYESLKRNFDKNCSYIIGDVVIAHITNENISFLNSIEDISGYLMIFSNAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMRRSQEVVIVETNEKDCGLNSKIDEELSCHESCQAHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILKTEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKHDGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCPKICRARDILDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYYVDSMKN--CYPCHTNCT-ENSQNKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFRSGMKV------NAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWHCSLCKYFRSDNKCIQKCPKEYFITVNETAKPESECKKCHEECSEGCLGSTNYDCLRCKHAKIYVNGS-TQFFCNSTCGDRIQLFQTSEIICT--DHLIYSRFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAHPKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQ 1233 The following BLAST results are available for this feature:
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Receptor protein-tyrosine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30004546 ID=SMED30004546|Name=Receptor protein-tyrosine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4250bpback to top protein sequence of SMED30004546-orf-1 >SMED30004546-orf-1 ID=SMED30004546-orf-1|Name=SMED30004546-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1284bp MGLVIPALVLLLSLRAIKPNPNHHKEINGNDSLVKINVSNFDRQASEFNLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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