Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30004531
Length (bp)1502
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30004531) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30004531) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bestrophin homolog (SMED30004531) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30004531) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30004531

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30004531SMESG000016290.1 dd_Smed_v4_11440_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30004531SMESG000016290.1 dd_Smed_v4_11440_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30004531SMESG000016290.1 dd_Smed_v4_11440_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 157.532 bits (397), Expect = 1.350e-42
Identity = 107/356 (30.06%), Postives = 178/356 (50.00%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +FI F+V Y+AI+++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +  F   + +    E   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F +++  S    +  P +W   L  KA  +G I+      +L   +  ++S  S L  ++   +PLVYTQV+ + VYTF  + L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTG--VQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEH-GRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTTDERKLFNHLK--SPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 157.147 bits (396), Expect = 7.570e-41
Identity = 107/356 (30.06%), Postives = 178/356 (50.00%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +FI F+V Y+AI+++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +  F   + +    E   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F +++    K  +  P +W   L  KA  +G I+      +L   +  ++S  S L  ++   +PLVYTQV+ + VYTF  + L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTG--VQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDE-HGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTTDERKLFNHLKSPHLK--YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST4 (bestrophin 4 [Source:HGNC Symbol;Acc:HGNC:17106])

HSP 1 Score: 153.295 bits (386), Expect = 2.144e-40
Identity = 102/359 (28.41%), Postives = 174/359 (48.47%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNE----------------NILIGS---YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F  LLLRW+GS++KLL+ +F+ F   Y+ +++ YR+ L  +  ++  +  +  Y N+ A ++PLSF+LGF+V+ V+ RWW    SIP   +      A +    +   + +R T++RY NLA +L +  +ST+V +RF                P +                  + +V   F   + ++E + FE+++   NK  +  P +W T L  +A RDG I+       L   +  +++  S L  ++  ++PLVYTQV+ I VY+F    L+  Q +  E                   +G    Y P+  + +F  Y GW K+    INPFG D  D   ++++D NL++S
Sbjct:   17 FSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQE--QRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASV-HGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRF----------------PTM------------------EHVVDAGF---MSQEERKKFESLKSDFNK--YWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVS 333
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 147.132 bits (370), Expect = 4.646e-38
Identity = 105/361 (29.09%), Postives = 174/361 (48.20%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F  FY A++  YR  L     +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+     L  ++  +VPLVYTQV+ I +Y++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTE--GQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMP--LPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 147.132 bits (370), Expect = 4.646e-38
Identity = 105/361 (29.09%), Postives = 174/361 (48.20%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F  FY A++  YR  L     +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+     L  ++  +VPLVYTQV+ I +Y++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTE--GQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMP--LPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-4 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17205])

HSP 1 Score: 149.058 bits (375), Expect = 7.614e-39
Identity = 94/359 (26.18%), Postives = 174/359 (48.47%), Query Frame = 1 
Query:  205 LKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHF--GKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS------YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYP 1257
            +K+LLRW+GS+WK +W + + + + YS ++++YR+ L  +  ++E FE +  + +  +  +P++F+LGF+VS V  RW K+ +++ W+   A T    I   +E   + IR   VRYM +A ++    +S  +++RF                P +                       KH     L+ EDE+  F+ +    +K  +  P+ W   L+  A  +G I    +  +L + +++F++ + NL + +   +PLVYTQV+ + V T+ +  L   Q + N N + G+      YFPI    + +  +GW K+    +NP G D  D   + I++ NL++   +       YP
Sbjct:   18 IKVLLRWKGSVWKSIWSELLIWLLCYSILSVIYRILL--NKAQREVFEQLCTFFDTFSVFIPVTFMLGFYVSIVYNRWTKVFDNVGWIDTSALTIAQYIRGTSEK-ARLIRRNCVRYMIVAQVMVFRDVSPAIRRRF----------------PTI-----------------------KHLIGAGLLTEDELTEFDAITSPQSK--YWQPIQWLFSLVTVAKDEGLIADSYLYVDLIDKMREFRTKILNLVIFDMVPIPLVYTQVVNLAVRTYFVLALFGRQFLENNNNIPGAKWKIDIYFPIMTSLQIVFIVGWLKVSEVMLNPLGEDDEDFETNWIIERNLQVGYAVVDQAYGRYP 332
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-3 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17206])

HSP 1 Score: 147.132 bits (370), Expect = 6.522e-38
Identity = 95/357 (26.61%), Postives = 167/357 (46.78%), Query Frame = 1 
Query:  208 KLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNEN-------ILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYP 1257
            KLL RW+GS+WK +W + + +   Y+ ++++YR  L     ++  FE + I+ +  +  +P++F+LGF+VS V  RWW+I ++I W+  P       I  +TE   K +R   +RY  L   +    ++  V++RF    T N +++                                    L+ E E+  FE++   S    +  P+ W   +I  A  +G I S  +  +L   ++ F+ N+ +L + +   VPLVYTQV+ + V ++ +  L   Q +  E+         I  Y PI ++ +FI ++GW K+    +NP G D  D   + ILD NL++   +       YP
Sbjct:   19 KLLFRWKGSIWKSVWAELVVWLCLYAVLSVIYRCLLTM--KQRATFEDLCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQYIKGETE-RAKCVRRNCIRYSILTQAMVYRDVAASVRKRF---PTFNHLVT----------------------------------AGLMTEKEMAEFESIP--SPHAKYWQPMHWLFSMITLARDEGMISSDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLIALFGRQYLHPESNRLNDFKQTIDLYVPIMSLLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRNLQVGLMVVDTAYNRYP 333
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-14 (Bestrophin homolog 14 [Source:UniProtKB/Swiss-Prot;Acc:Q19978])

HSP 1 Score: 142.895 bits (359), Expect = 1.509e-37
Identity = 106/356 (29.78%), Postives = 169/356 (47.47%), Query Frame = 1 
Query:  178 ISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENIL---IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIAS 1236
            IS +E  +F  L+LRW+GS+WK +  D I F + Y  I + ++ YL+ D   KE F   +++    A  +PLSFLLGFFVS ++ RWW+  N I W  K      A +  +   +   +R TI R+ +L   ++   +S K  +RF    T   +++                                   KL+ E+E  ++ N +    K  +  P++W   LI+K  + G I S  +   L   V  ++   + L V++   +PLVYTQV+ I  Y +    L+  Q   ++  +   I   FPIF  F+ + Y+GW K+G   +NPFG D  D  L+ +LD N  I+  +AS
Sbjct:    3 ISYDE--EFSSLMLRWRGSIWKAVLKDLIGFYIAYY-IVLAFQWYLL-DEKGKEYFTGWIMWCEIGAQYIPLSFLLGFFVSLIVARWWEQFNCISWPDKMMIMVSACLPGNENMV---VRQTIARWSSLQAAIAWSGVSVKTLKRF---PTERHMVA----------------------------------SKLMTEEEYDLYMNTDAPHGK--WFIPILWIVNLIKKQKQKGIIDSIQMDM-LLKQVYSYRDGFAMLFVYDWIKIPLVYTQVVAIATYGYFFICLIGRQPKLDQRSMEKEITILFPIFTTFQMLFYLGWLKVGQYLMNPFGEDDDDFELNYVLDRNTAIAHMMAS 311
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-23 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A5JYR2])

HSP 1 Score: 139.428 bits (350), Expect = 2.322e-36
Identity = 98/348 (28.16%), Postives = 163/348 (46.84%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENV-EHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIIS-NEN-ILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIAS 1236
            FLKLL RW+GSLWK +W   + F   Y  I   YR  +  +  ++  F   V+ ++     +PL+FLLGF+V+ ++ RWW     I W     +   ALI    +P  + IR TI RY  L  +L+   +S +V  R+    T + ++                                     L+ ++E+ +F+++  H+     +  PL W   ++ +    G +        L + ++ +++    L +++   +PLVYTQV  I VY + +  L+  Q  S NEN  ++  Y PIF I +F+ Y+GW K+G   + PFG+D  D   + IL+ NLE+S  I  
Sbjct:    9 FLKLLFRWKGSLWKAIWKHLLIFLTMYYIINAYYRFGMTKE--QQNEFIKYVMLVDGWTKEIPLTFLLGFYVAMIVRRWWDCCQLISWPDHLLYNVSALI-RGQDPETRIIRKTIARYTILTSVLAWRSISLRVLARY---PTDDHLVD----------------------------------SGLMTKEEMVMFKSILVHVDPHQKWWVPLNWIQTMMVRCFEKGTLTHTNELRVLLDALEKYRNGFFQLFIYDWIAIPLVYTQVSTISVYGYFLFALIGRQYPSKNENEEIVDVYVPIFTILQFLFYVGWLKVGEDLMFPFGADDEDFEFNYILERNLEVSMLIVD 316
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-22 (Bestrophin homolog 22 [Source:UniProtKB/Swiss-Prot;Acc:Q23369])

HSP 1 Score: 139.043 bits (349), Expect = 1.045e-35
Identity = 106/378 (28.04%), Postives = 187/378 (49.47%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDF-IWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYL-NKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQ-IISNEN-ILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYN----LEISSTIASGEDFYYP---EYLTKTFKDPEDSPW 1302
            F  LLLRW+GS+WK ++    +W +VF   I+ +YR  L   P++++ FE ++ Y  NK+   +PL+FLLGFFVS V+ RW  I+N I W+   +      I    E   + IR  +VRY+ L+  L +  +S +V++RF                P ++T++                        L+  +E+ + ++++   ++  + T + W+  L+ +  + G + S  +   + + +  F+  L++L  ++   VPLVY QVI + V  + +  L+  Q I++  N   I  + PI  + +F++YMGW K+  + +NP G D  DL  + I+D N    L I  T+   +D  Y    E++ KT    +D  W
Sbjct:   17 FFSLLLRWRGSVWKAVFGQLAVWTAVFL-LISCIYRYML--SPSQQDVFEQLIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEE-TRVIRRNLVRYLVLSQALVLRDISMQVRKRF----------------PTMDTLAA---------------------SGLMTHEEMDILDHIKDPYSR--YWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSIVDTMWKHDDTGYSMVEEHMAKTPAQKKDEFW 351
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 189.889 bits (481), Expect = 1.460e-52
Identity = 126/399 (31.58%), Postives = 200/399 (50.13%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPA-FTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPS-FITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQ-----IISNENIL--IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKD---PEDSPWK-QLEKFRLLVPESFNVKKE 1359
            FLKLLLRW+GS++KL+W+D + F   Y AI M+YR  L  +P +KE FE+IV Y +    ++PLSF+LGF+VS V+ RWW    SIPW    A F    +  +D     + +R TI+RY+ L   + +  +S +VK+RF                P LN + +                       L+ ++E  + E +     +PS    P++W   +I +A ++G I+       + + +  F+     L  ++  +VPLVYTQV+ + VY++ ++  + +Q     ++ N   L  +  YFP+F   +F  YMGW K+  S INPFG D  D  ++ ++D NL++S  I       +PE L   + D   P + P+    E+FR   PE    K E
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGL--NPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDER--GRMMRRTIMRYVCLCLTMVLANVSPRVKKRF----------------PGLNNLVE---------------------AGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIE 375
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 190.274 bits (482), Expect = 1.567e-52
Identity = 125/398 (31.41%), Postives = 199/398 (50.00%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPS-FITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQ-----IISNENIL--IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKD---PEDSPWK-QLEKFRLLVPESFNVKKE 1359
            FLKLLLRW+GS++KL+W+D + F   Y AI M+YR  L  +P +KE FE+IV Y +    ++PLSF+LGF+VS V+ RWW    SIPW    A    + +    E   + +R TI+RY+ L   + +  +S +VK+RF                P LN + +                       L+ ++E  + E +     +PS    P++W   +I +A ++G I+       + + +  F+     L  ++  +VPLVYTQV+ + VY++ ++  + +Q     ++ N   L  +  YFP+F   +F  YMGW K+  S INPFG D  D  ++ ++D NL++S  I       +PE L   + D   P + P+    E+FR   PE    K E
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGL--NPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDE-RGRMMRRTIMRYVCLCLTMVLANVSPRVKKRF----------------PGLNNLVE---------------------AGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIE 375
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023)

HSP 1 Score: 189.889 bits (481), Expect = 3.288e-52
Identity = 125/398 (31.41%), Postives = 199/398 (50.00%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPS-FITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQ-----IISNENIL--IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKD---PEDSPWK-QLEKFRLLVPESFNVKKE 1359
            FLKLLLRW+GS++KL+W+D + F   Y AI M+YR  L  +P +KE FE+IV Y +    ++PLSF+LGF+VS V+ RWW    SIPW    A    + +    E   + +R TI+RY+ L   + +  +S +VK+RF                P LN + +                       L+ ++E  + E +     +PS    P++W   +I +A ++G I+       + + +  F+     L  ++  +VPLVYTQV+ + VY++ ++  + +Q     ++ N   L  +  YFP+F   +F  YMGW K+  S INPFG D  D  ++ ++D NL++S  I       +PE L   + D   P + P+    E+FR   PE    K E
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGL--NPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDE-RGRMMRRTIMRYVCLCLTMVLANVSPRVKKRF----------------PGLNNLVE---------------------AGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIE 375
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 189.504 bits (480), Expect = 3.614e-52
Identity = 126/399 (31.58%), Postives = 200/399 (50.13%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPA-FTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPS-FITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQ-----IISNENIL--IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKD---PEDSPWK-QLEKFRLLVPESFNVKKE 1359
            FLKLLLRW+GS++KL+W+D + F   Y AI M+YR  L  +P +KE FE+IV Y +    ++PLSF+LGF+VS V+ RWW    SIPW    A F    +  +D     + +R TI+RY+ L   + +  +S +VK+RF                P LN + +                       L+ ++E  + E +     +PS    P++W   +I +A ++G I+       + + +  F+     L  ++  +VPLVYTQV+ + VY++ ++  + +Q     ++ N   L  +  YFP+F   +F  YMGW K+  S INPFG D  D  ++ ++D NL++S  I       +PE L   + D   P + P+    E+FR   PE    K E
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGL--NPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDER--GRMMRRTIMRYVCLCLTMVLANVSPRVKKRF----------------PGLNNLVE---------------------AGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIE 375
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best2 (gene:FBgn0035696 transcript:FBtr0077010)

HSP 1 Score: 176.407 bits (446), Expect = 1.772e-47
Identity = 115/404 (28.47%), Postives = 201/404 (49.75%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKD----IRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS-----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKD---PEDSPWK-QLEKFRLLVP----ESFNVKKEE 1362
            F K+L +W+GS++KL+W + + +   Y  I ++YR  L    +++  F+ I +Y  + +  +P+SF+LGF+V+ V+ RWW+    +PW    A    A I      +  +    +R  I+RYM LA+++++  +S +VK+RF    TT  ++                                     L+ E E+++FE +   S    +  PL+W T +I +A +DG I S  +   +   + D +  L  L  ++   VPLVYTQV+ +V+YT+ I+ LL  Q++ N     G      +FP+F + +F+ Y+GW K+    INPFG D  D+ L+ ++D +++ +  I       +PE L   + +   P+D P+    E +R   P    E + VKKE+
Sbjct:   18 FWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTE--SQQAIFKKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLMRRNIMRYMVLAYVITLQRISLRVKRRF---PTTQHLVDA----------------------------------GLMHESEMKIFEALNQKSPMSKYWMPLVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAALLGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKED 382
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 159.458 bits (402), Expect = 6.543e-44
Identity = 105/344 (30.52%), Postives = 178/344 (51.74%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F KLL RW+GS++KLL+ +F+ F + Y+ I++LYR  L  + N++E F  +  + NK A ++P+SF+LGF+V+    RWW    S P            +   T+   + +R T++RY NL+ +L +  +ST+V++RF          + L+D                        IV+  F   +  DE+R   ++    NK  +  PL W   L  +A ++G +K       L + + +++S  S L  ++  ++PLVYTQV+ + VY+F    L+  Q +    S E++ +  Y PIF + +F  Y GW K+G   INPFG D  D   ++++D N+++S
Sbjct:   17 FSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVL--NNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNV-HGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRF----------TTLED------------------------IVEAGF---MTTDELRKLNHLYSDFNK--YWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDL--YIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVS 316
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 157.532 bits (397), Expect = 1.634e-43
Identity = 104/343 (30.32%), Postives = 177/343 (51.60%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEI 1218
            F KLL RW+GS++KLL+ +F+ F + Y+ I++LYR  L  + N++E F  +  + NK A ++P+SF+LGF+V+    RWW    S P            +   T+   + +R T++RY NL+ +L +  +ST+V++RF          + L+D                        IV+  F   +  DE+R   ++    NK  +  PL W   L  +A ++G +K       L + + +++S  S L  ++  ++PLVYTQV+ + VY+F    L+  Q +    S E++ +  Y PIF + +F  Y GW K+G   INPFG D  D   ++++D N+++
Sbjct:   17 FSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVL--NNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNV-HGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRF----------TTLED------------------------IVEAGF---MTTDELRKLNHLYSDFNK--YWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDL--YIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQV 315
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 159.844 bits (403), Expect = 5.769e-42
Identity = 100/344 (29.07%), Postives = 169/344 (49.13%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F +LLLRW+GS++KLL+ + + F+V Y  I++ YR  L  +  ++  FE + +Y ++ A ++P+SF+LGF+V+ V+ RWW    S+PW  + +      +    E   + IR +++RY NL+ IL    +ST V +RF   S               + +  G                      L+  +E+R  + +    NK  F  P MW   L  +A  +G I +      + N +   +S    L  ++  ++PLVYTQV+ + VY+F ++ L+  Q +       G     Y P+F + +F  Y+GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEE--QRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADE-GARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMS---------------HLVQAG----------------------LMTAEELRQLQELPSPHNK--FWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 150.984 bits (380), Expect = 4.386e-40
Identity = 107/362 (29.56%), Postives = 178/362 (49.17%), Query Frame = 1 
Query:  157 ITMYLSAISLNER-IKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLG--FFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F KLLL W+GS++K+L+ +F+ F   Y+AI++ YR +L+    +K  FE + IY +  A ++P+SF+LG  F+V+ V+ RWW    SIP   +        + + ++   + +R T++RY +L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FE++    NK  +  P +W T L   A  +G IK       L   + +F+   S L  ++  +VPLVYTQV+ + VY+F +  L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVD--GQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGV-QGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFESLHSPYNK--YWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPGQGYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVS 320
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 94.7449 bits (234), Expect = 1.088e-21
Identity = 70/244 (28.69%), Postives = 121/244 (49.59%), Query Frame = 1 
Query:  157 ITMYLSAISLNER-IKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIK 885
            +T+  +A   N R   F KLLL W+GS++K+L+ +F+ F   Y+AI++ YR +L+    +K  FE + IY +  A ++P+SF+LGF+V+ V+ RWW    SIP   +        + + ++   + +R T++RY +L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FE++    NK  +  P +W T L   A  +G IK
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVD--GQKRYFEKLSIYCDNYASLIPMSFVLGFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGV-QGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFESLHSPYNK--YWIPCVWFTNLAAAARCEGRIK 202
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: ifitm3 (interferon induced transmembrane protein 3 [Source:Xenbase;Acc:XB-GENE-5852510])

HSP 1 Score: 155.992 bits (393), Expect = 1.592e-40
Identity = 102/356 (28.65%), Postives = 180/356 (50.56%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +F+ F+  Y+ ++++YR +L    ++K  FE + +Y +K A  +P++F+LGF+V+ V+ RWW    ++PW  +  F   + +    E   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F++++  S    +  P++W   L  KA  +G I+       + N +  F+S  S L  ++   +PLVYTQV+ + VYTF  + ++  Q +  +    G     Y P+F + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFLLFTSLYTTLSVIYRFFLTD--SQKRYFEKVSMYCDKYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSNVHGRDE-YGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTSDERKLFDSLK--SPHLKYWVPVIWFGNLASKARSEGRIRDSIDLQMMMNEMNKFRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPKQAYPGHDLDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: cyp2b6 (cytochrome P450 family 2 subfamily B member 6 [Source:Xenbase;Acc:XB-GENE-5779150])

HSP 1 Score: 149.443 bits (376), Expect = 8.142e-39
Identity = 104/354 (29.38%), Postives = 176/354 (49.72%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENIL----IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFY 1251
            F KLL RW+GS++KLL+ +FI F   Y+ +++ YR  L  +  +K  F  +  Y N+   ++P+SF+LGF+V+ ++ RWW    +IP   +      + +    E   + +R T++RY NL+ +L +  +ST+V +RF                P +                  + IV+  F   +  +E++ +E +    NK  +  P +W T L  +A RDG ++       L + +  +++  S L  ++  +VPLVYTQV+ I VY+F    ++  Q +  E       I  Y PIF + +F  Y GW K+    INPFG D  D   + ++D NL++S  + S +D Y
Sbjct:   17 FFKLLFRWKGSIYKLLYKEFIVFCCLYAMLSVTYRCLL--NEKQKSEFAQLARYCNQYTDLIPVSFVLGFYVTLIVNRWWAQYTNIPLPDQLMCVVSSNVHGGDE-RGRLLRRTMMRYANLSSVLILRSVSTRVLKRF----------------PTM------------------EHIVEAGF---MTREELKKYECLFSDYNK--YWIPCVWFTNLAAQARRDGRVRDDVALKLLMDELNKYRAKCSMLFHYDWISVPLVYTQVVTIAVYSFFGVCIIGRQFLEPELEEEKPNIDLYVPIFTLLQFFFYSGWLKVAQQIINPFGEDDDDFETNRLIDRNLQVS--LLSVDDMY 326
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 145.591 bits (366), Expect = 2.186e-38
Identity = 98/344 (28.49%), Postives = 166/344 (48.26%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F +LLLRW+GS++KLL+ +F+ F   Y  I++ YR  L  +  ++  FE + +Y +  A ++P+SF+LGF+V+ V+ RWW    S+PW  +      + +   T+   + +R T++RY NL  +L +  +ST V  RF    T   +++    +P               ++   D +V  H                    NK  F  P +W   L   A  +G I+   V   +   +   ++    L  ++  +VPLVYTQV+ + VY+F ++ L+  Q +  +    G     Y P+F + +F  Y GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLL--NEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNV-HGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRF---PTLQHVVNAGFMTPT--------------ERSKFDGLVSSH--------------------NK--FWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 145.591 bits (366), Expect = 2.324e-38
Identity = 98/344 (28.49%), Postives = 166/344 (48.26%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F +LLLRW+GS++KLL+ +F+ F   Y  I++ YR  L  +  ++  FE + +Y +  A ++P+SF+LGF+V+ V+ RWW    S+PW  +      + +   T+   + +R T++RY NL  +L +  +ST V  RF    T   +++    +P               ++   D +V  H                    NK  F  P +W   L   A  +G I+   V   +   +   ++    L  ++  +VPLVYTQV+ + VY+F ++ L+  Q +  +    G     Y P+F + +F  Y GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLL--NEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNV-HGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRF---PTLQHVVNAGFMTPT--------------ERSKFDGLVSSH--------------------NK--FWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 145.591 bits (366), Expect = 4.568e-38
Identity = 98/344 (28.49%), Postives = 166/344 (48.26%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F +LLLRW+GS++KLL+ +F+ F   Y  I++ YR  L  +  ++  FE + +Y +  A ++P+SF+LGF+V+ V+ RWW    S+PW  +      + +   T+   + +R T++RY NL  +L +  +ST V  RF    T   +++    +P               ++   D +V  H                    NK  F  P +W   L   A  +G I+   V   +   +   ++    L  ++  +VPLVYTQV+ + VY+F ++ L+  Q +  +    G     Y P+F + +F  Y GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLL--NEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNV-HGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRF---PTLQHVVNAGFMTPT--------------ERSKFDGLVSSH--------------------NK--FWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best3 (bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298])

HSP 1 Score: 157.918 bits (398), Expect = 3.165e-41
Identity = 105/356 (29.49%), Postives = 180/356 (50.56%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +FI F+V Y+AI+++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +      + +   ++   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F++++    K  +  P +W   L  KA  +G I+      +L   +  ++S  S L  ++   +PLVYTQV+ + VYTF  + L+  Q +      +G     Y PIF + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTG--AQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSV-HGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTADERKLFDHLKSPHLK--YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 145.976 bits (367), Expect = 2.518e-38
Identity = 101/356 (28.37%), Postives = 169/356 (47.47%), Query Frame = 1 
Query:  187 NERI-KFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASG 1239
            N R+  F  LLL W+GS++KLL+ +F+ F   Y +I  LYRM L  D  ++  FE + +Y +    ++P+SF+LGF+V+ V+ RWW    ++PW  +      + + E  +   + +R T++RY  L  +L +  +ST V +RF                P L+ +                          +   E +  + +    N  +F  P +W   L  KA+  G I+   +  +L N V   ++    L  ++  ++PLVYTQV+ + VY+F ++ L+  Q ++      G       P+F I +F+ YMGW K+    INPFG D  D   + I+D NL++S     G
Sbjct:   11 NARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSD--QQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFV-EGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRF----------------PTLHHLV---------------------LAGFMTHGEHKQLQKLGLPHN--TFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDG 324
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 146.362 bits (368), Expect = 6.602e-38
Identity = 105/361 (29.09%), Postives = 175/361 (48.48%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F   Y A++  YR  L  +  +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+S    L  ++  ++PLVYTQV+ I VY++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEE--QKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMP--LPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 146.362 bits (368), Expect = 6.602e-38
Identity = 105/361 (29.09%), Postives = 175/361 (48.48%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F   Y A++  YR  L  +  +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+S    L  ++  ++PLVYTQV+ I VY++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEE--QKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMP--LPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 146.362 bits (368), Expect = 6.602e-38
Identity = 105/361 (29.09%), Postives = 175/361 (48.48%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F   Y A++  YR  L  +  +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+S    L  ++  ++PLVYTQV+ I VY++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEE--QKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMP--LPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q6H1V1|BEST3_MOUSE (Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=2 SV=1)

HSP 1 Score: 157.918 bits (398), Expect = 2.214e-40
Identity = 105/356 (29.49%), Postives = 180/356 (50.56%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +FI F+V Y+AI+++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +      + +   ++   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F++++    K  +  P +W   L  KA  +G I+      +L   +  ++S  S L  ++   +PLVYTQV+ + VYTF  + L+  Q +      +G     Y PIF + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTG--AQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSV-HGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTADERKLFDHLKSPHLK--YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8N1M1|BEST3_HUMAN (Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 3.635e-40
Identity = 107/356 (30.06%), Postives = 178/356 (50.00%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++      F +LLL+W+GS++KLL+ +FI F+V Y+AI+++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +  F   + +    E   + +R T++RY+NL  +L    +ST V +RF                P +                  D +V+  F   +  DE ++F +++    K  +  P +W   L  KA  +G I+      +L   +  ++S  S L  ++   +PLVYTQV+ + VYTF  + L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:    5 YSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTG--VQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDE-HGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTTDERKLFNHLKSPHLK--YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU0|BEST4_HUMAN (Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 1.029e-39
Identity = 102/359 (28.41%), Postives = 174/359 (48.47%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNE----------------NILIGS---YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F  LLLRW+GS++KLL+ +F+ F   Y+ +++ YR+ L  +  ++  +  +  Y N+ A ++PLSF+LGF+V+ V+ RWW    SIP   +      A +    +   + +R T++RY NLA +L +  +ST+V +RF                P +                  + +V   F   + ++E + FE+++   NK  +  P +W T L  +A RDG I+       L   +  +++  S L  ++  ++PLVYTQV+ I VY+F    L+  Q +  E                   +G    Y P+  + +F  Y GW K+    INPFG D  D   ++++D NL++S
Sbjct:   17 FSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQE--QRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASV-HGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRF----------------PTM------------------EHVVDAGF---MSQEERKKFESLKSDFNK--YWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVS 333
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU1|BEST2_HUMAN (Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 2.231e-37
Identity = 105/361 (29.09%), Postives = 174/361 (48.20%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F  FY A++  YR  L     +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+     L  ++  +VPLVYTQV+ I +Y++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTE--GQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMP--LPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1)

HSP 1 Score: 146.362 bits (368), Expect = 5.199e-37
Identity = 105/361 (29.09%), Postives = 175/361 (48.48%), Query Frame = 1 
Query:  157 ITMYLSAISLNERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTC-QALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQII----SNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F +LLL W+GS++KLLW + + F   Y A++  YR  L  +  +K  FE +VIY ++ A ++P+SF+LGF+V+ V+ RWW     +P     A  C  A      +   +  R T++RY  L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FEN+    NK  +  P +W + L  +A R+G I+       L   +  F+S    L  ++  ++PLVYTQV+ I VY++ ++ L+  Q +      ++  +    PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEE--QKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMP--LPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF----------------PTI------------------DHVVEAGF---MTREERKKFENLNSSYNK--YWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267DQK5 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017879g3 PE=3 SV=1)

HSP 1 Score: 275.789 bits (704), Expect = 4.258e-82
Identity = 166/470 (35.32%), Postives = 242/470 (51.49%), Query Frame = 1 
Query:  154 VITMYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDI----RLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISC---------------LKDSPNLNTISKGKNV----RKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNK------PSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNE----------------------NILIG----SYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHM 1398
            ++  Y S I   +R+ FLKLL RW GS+W++LWVD+I+F   Y  + ++Y   L +  ++   FE++V +L+K+   VPLSF+LGFFVSTV  RWW    +IPW++  +F  QAL+ E T P+  DI    R+TI+RY NL+WIL +  +S ++K RF          S                  DS + N  SK        R+++D INSDE V+KHFG+L+  +E+  F     +S        P +  PL W +RLI++A   G I  +     L  M+  F+ +L  +  + EFNVPLVYTQV +  VY FL S LLS Q+I  E                      + ++G    +YFPI    +FI Y+GWFK+G+  +NP G D +DLPL +IL+ NL+ S  +   ED  +P  LT         P +Q     L   +   V   +   S   V+ H+
Sbjct:    1 MVVSYASKIYTKDRLFFLKLLFRWTGSVWEMLWVDYIFFVTAYVILAVIYHQALANHEHRMITFEAVVRWLSKIRTSVPLSFMLGFFVSTVFSRWWSTCMAIPWLSSMSFYTQALV-ESTHPVKSDIARKIRITILRYSNLSWILMMATISQQIKDRFGFNQPLKAKKSSQDRSAGTTAAATAGTGNDSTDGNKNSKKPEFELTWRERLDLINSDEKVRKHFGRLVTAEEVETFARSAELSQSTDLTYSPEYWLPLAWASRLIKRARMLGLIAEERELLFLVEMINKFRGDLGTVWSYTEFNVPLVYTQVAVAAVYLFLFSTLLSTQLIRPEMVRQVTMAPAAQSINETQSSVIDTVLGVELLAYFPILGSLEFIFYLGWFKIGIMLLNPLGKDRADLPLSDILNSNLKASVKLGGAEDSLFPPGLTDN-----GEPVEQQVSLLLRAFDFSEVHAHDNFTSAEEVEAHL 464
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267FRV1 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021055g1 PE=3 SV=1)

HSP 1 Score: 273.478 bits (698), Expect = 1.527e-81
Identity = 144/403 (35.73%), Postives = 223/403 (55.33%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITED---TEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSN------KPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIIS-------------------NENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPE 1290
            Y S I   +R+ F+KLL RW GS+W+LLW+DF+ F + Y ++  LY + L +DP  K  FE  V +L  V+  VPLSF+LGFFVS+V+ RWW +  SIPW+  P+F CQAL+         L + +R+T++RY+NLAWIL +  +S  +++RF                P   T       R+++  +NSDE V+K+FG+L+ ++EI  F     +SN       P +  PL+W TRLI +A     I  +  C  L + VQ F+ +L  + +  EFN+PLVY QV +  VY +L+S ++S Q++                    N    +  + P+    +FI Y+GWFK+G+  +NP G D +D+P+ +IL+ NL+ +  +   ED  +P  LT + +  E
Sbjct:    5 YASKIYTKDRLFFIKLLFRWSGSVWQLLWLDFLVFILIYVSLAALYHLVLYNDPKMKATFEITVSWLKTVSTAVPLSFMLGFFVSSVVERWWSVCMSIPWLQTPSFYCQALLDSPKTYRSDLARKLRITVLRYLNLAWILMMAGVSLHIRERFGYW------------QPKWKTKKYKLTWRRRLKMVNSDEKVQKYFGQLVTDNEIAAFGRSAELSNDNKHTYDPEYWLPLVWATRLIRRARNLDCIADERHCLWLIDTVQKFRYDLGTIWMFTEFNIPLVYVQVAVTAVYLYLVSTIISTQLMDSDIVQSSTAILNVNGTYQRNTGQQVLGFIPVLGGLEFIFYLGWFKIGMCLLNPMGKDEADIPMSDILNSNLKAAIKMGGAEDSIFPRGLTDSGEAEE 395
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267EEP4 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017879g1 PE=3 SV=1)

HSP 1 Score: 273.478 bits (698), Expect = 3.896e-81
Identity = 165/470 (35.11%), Postives = 241/470 (51.28%), Query Frame = 1 
Query:  154 VITMYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDI----RLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISC---------------LKDSPNLNTISKGKNV----RKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNK------PSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNE----------------------NILIG----SYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHM 1398
            ++  Y S I   +R+ FLKLL RW GS+W++LWVD+I+F   Y  + ++Y   L +  ++   FE++V +L+K+   VPLSF+LGFFVSTV  RWW    +IPW++  +F  QAL+ E T P+  DI    R+TI+RY NL+WIL +  +S ++K RF          S                  DS + N  SK        R+++D IN DE V+KHFG+L+  +E+  F     +S        P +  PL W TRLI+++   G I  +     L  M+  F+ +L  +  + EFNVPLVYTQV +  VY FL S LLS Q+I  E                      + ++G    +YFPI    +FI Y+GWFK+G+  +NP G D +DLPL +IL+ NL+ S  +   ED  +P  LT         P +Q     L   +   V   +   S   V+ H+
Sbjct:    1 MVVSYASKIYTKDRLFFLKLLFRWTGSVWEMLWVDYIFFVTAYVILAVIYHQALANHEHRMITFEAVVRWLSKIRTSVPLSFMLGFFVSTVFSRWWSTCMAIPWLSSMSFYTQALV-ESTHPVKSDIARKIRITILRYSNLSWILMMATISQQIKDRFGFNQPLKAKKSSQDRSAGTTAAATAGTGNDSTDGNKNSKKPEFELTWRERLDLINLDEKVRKHFGRLVTAEEVETFARSAELSQSTDLTYSPEYWLPLAWATRLIKRSRMLGLIAEERELLFLVEMINKFRGDLGTVWSYTEFNVPLVYTQVAVAAVYLFLFSTLLSTQLIRPEMVRQVTMAPAAESINETQSSVIDTVLGVELLAYFPILGSLEFIFYLGWFKIGIMLLNPLGKDRADLPLSDILNSNLKASVKLGGAEDSLFPPGLTDN-----GEPVEQQVSLLLRAFDFSEVHAHDNFTSAEEVEAHL 464
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267GVI2 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig001426g2 PE=3 SV=1)

HSP 1 Score: 271.937 bits (694), Expect = 5.952e-81
Identity = 144/402 (35.82%), Postives = 222/402 (55.22%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITE---DTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSN------KPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIG------------------SYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPE 1290
            Y S I  ++R+ F++LL RW GS+W+LLW+D++ F++ Y  + +LY   L      K  FE  V +L  +   VPLSF+LGFFVS V GRWW +  SIPW+   +F CQAL+         L + +R+T++RY+NLAWIL +  +S  +K+RF       +                    ++++  INSD  V+K+FG+L+ E E++ F     +SN       P +  PLMW TRLI +A   G I  +     L N++ +F+ +L  + ++ EFN+PLVYTQV +  VY FL S L+S Q++ ++ +L+                   SY P+    +FI Y+GWFK+G+  +NP G D +D+P+ +IL+ NL+ S  I   ED  +P  LT + +  E
Sbjct:    5 YASQIYTDDRLFFVRLLFRWAGSVWQLLWIDYLIFTLMYVGLAVLYFNLLYTHAELKATFEVTVAWLKAIRTSVPLSFMLGFFVSAVFGRWWSVCTSIPWLHSSSFYCQALVDSPKTSRSDLARKLRITVLRYLNLAWILMMAGVSLHIKERFGYWQPKWRKFQL--------------TWQRRLQLINSDSKVQKYFGQLVTEKEMQAFAKSAELSNDNDHSYDPEYWLPLMWATRLIRRAKNLGCIADERQYLFLVNIINNFRGDLGTVWMYTEFNIPLVYTQVAVTAVYLFLASTLISTQLVDSDILLLENFPSRNGTVTRTLGLNLLSYLPVIGSLEFIFYLGWFKIGMCLLNPMGKDKADIPMSDILNSNLKASVKIGGAEDSIFPGGLTDSGEAEE 392
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267E363 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013525g1 PE=3 SV=1)

HSP 1 Score: 273.092 bits (697), Expect = 6.061e-81
Identity = 165/470 (35.11%), Postives = 241/470 (51.28%), Query Frame = 1 
Query:  154 VITMYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDI----RLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCL---------------KDSPNLNTISKGKNV----RKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNK------PSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNE----------------------NILIG----SYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHM 1398
            ++  Y S I   +R+ FLKLL RW GS+W++LWVD+I+F   Y  + ++Y   L +  ++   FE++V +L+K+   VPLSF+LGFFVSTV  RWW    +IPW++  +F  QAL+ E T P+  DI    R+TI+RY NL+WIL +  +S ++K RF          S                  DS + N  SK        R+++D IN DE V+KHFG+L+  +E+  F     +S        P +  PL W TRLI+++   G I  +     L  M+  F+ +L  +  + EFNVPLVYTQV +  VY FL S LLS Q+I  E                      + ++G    +YFPI    +FI Y+GWFK+G+  +NP G D +DLPL +IL+ NL+ S  +   ED  +P  LT         P +Q     L   +   V   +   S   V+ H+
Sbjct:    1 MVVSYASKIYTKDRLFFLKLLFRWTGSVWEMLWVDYIFFVTAYVILAVIYHQALANHEHRMITFEAVVRWLSKIRTSVPLSFMLGFFVSTVFSRWWSTCMAIPWLSSMSFYTQALV-ESTHPVKSDIARKIRITILRYSNLSWILMMATISQQIKDRFGFNQPLKAKKSSQDRSAGTTAAATAGTDNDSTDGNKNSKKPEFELTWRERLDLINLDEKVQKHFGRLVTAEEVETFARSAELSQSTDLTYSPEYWLPLAWATRLIKRSRMLGLIAEERELLFLVEMINKFRGDLGTVWSYTEFNVPLVYTQVAVAAVYLFLFSTLLSTQLIRPEMVRQVTMAPAAESINETQSSVIDTVLGVELLAYFPILGSLEFIFYLGWFKIGIMLLNPLGKDRADLPLSDILNSNLKASVKLGGAEDSLFPPGLTDN-----GEPVEQQVSLLLRAFDFSQVHAHDNFTSAEEVEAHL 464
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 162.925 bits (411), Expect = 5.805e-43
Identity = 104/344 (30.23%), Postives = 170/344 (49.42%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F  LLLRW+GS++KLL+ + + F+V Y  I++LYR  L  D  ++  FE + IY ++ A ++P+SF+LGF+V+ V+ RWW    S+PW  + A    A +    E   + IR ++VRY NL+ +L    +ST V +RF                P +  + +                       L+  +E R  +++    NK  F  P MW   L  +A  +G I +      + N +   +S    L  ++  ++PLVYTQV+ + VY+F ++ L+  Q +       G     Y P+F + +F  Y+GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLL--DNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADE-GARLIRRSLVRYANLSGVLIYRSISTAVYKRF----------------PTIEHLVQ---------------------AGLMTVEERRQLDDLPSPHNK--FWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 154.836 bits (390), Expect = 2.368e-40
Identity = 108/360 (30.00%), Postives = 175/360 (48.61%), Query Frame = 1 
Query:  157 ITMYLSAISLNER-IKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F KLLL W+GS++K+L+ + + F + Y+AI++ YR +L+ +  +K  FE + IY N  A ++P+SF+LGF+V+ ++ RWW    SIP            +    E   + +R T++RY +LA +L +  +ST V +RF                P +                  D +V+  F   +  +E + FE++    NK  +  P +W T L   A  +G IK       L   +  F+   S L  ++  +VPLVYTQV+ + VY+F +  L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWRGSIYKVLYKEVLAFFILYTAISITYRFFLLDE--QKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDE-RGRLLRRTLMRYASLASLLILRSVSTAVFKRF----------------PTM------------------DHVVEAGF---MTREERKKFESLHSPYNK--YWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 144.05 bits (362), Expect = 3.125e-38
Identity = 97/346 (28.03%), Postives = 164/346 (47.40%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXX-XXYTFLISELLSEQIISNEN-----ILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F KLL RW+GS++KLL+ +F+ F   YS  +++YR  L     ++E FE    + NK A ++P+SF+L F+V+    RWW    S P            +   ++   + +R T++RY NL+ +L +  +ST+V +RF                P L  I                          + E+E+R  +++    NK  +  PL W   L  KA  +G +K       L + + +++   S L  ++  ++PLVYTQ ++   VY+F    L+  Q +  E      + +  Y P+F + +F  Y GW K+G   INPFG D  D   ++++D N+++S
Sbjct:   17 FTKLLFRWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTD--GQQELFERAARHCNKFAKLIPMSFVL-FYVTQAFQRWWGQYTSFPLPDNLMMVVSGNV-HGSDERGRLLRRTLMRYANLSSVLILRSISTRVHKRF----------------PTLQHIVDA----------------------FMTEEEMRTLDHLYSDFNK--YWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVHVDLYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 139.813 bits (351), Expect = 5.077e-35
Identity = 97/344 (28.20%), Postives = 157/344 (45.64%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F  LLLRW+GS++KLL+ + + F+V Y  I++LYR  L  D  ++  FE + IY ++ A ++P+SF+LGF+V+ V+ RWW    S+PW  + A    A +    E   + IR ++VRY NL+ +L    +ST V +RF                P +  + +                       L+  +E R  +++    NK  F  P MW   L  +A  +G I +      + N+V         +AV                  Y+F ++ L+  Q +       G     Y P+F + +F  Y+GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLL--DNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADE-GARLIRRSLVRYANLSGVLIYRSISTAVYKRF----------------PTIEHLVQ---------------------AGLMTVEERRQLDDLPSPHNK--FWVPCMWFVNLALRARTEGRINNDVALSAILNVV--------TVAV------------------YSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVS 292
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 82.8037 bits (203), Expect = 1.513e-16
Identity = 49/159 (30.82%), Postives = 80/159 (50.31%), Query Frame = 1 
Query:  757 LIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
             +  +E ++FEN++    K  +  P +W T L  KA +DG I+       +   +  F++  S L  ++   +PLVYTQV+ + VYTF  + ++  Q +       G     Y P+F + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:   84 FMTPEEKKIFENLKSPHLK--YWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFLDPAQGYPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVS 240

HSP 2 Score: 67.0106 bits (162), Expect = 1.796e-11
Identity = 31/82 (37.80%), Postives = 59/82 (71.95%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGF 411
            Y S ++      F +LLLRW+GS++KLL+ +F++F++ YS ++++YR +++ DP ++  FE + IY ++ A  +P++F+LGF
Sbjct:    5 YSSKVANATFFGFHRLLLRWRGSIYKLLYREFLFFALLYSILSLVYR-WVLTDPQRR-LFEKLSIYCDRYAEQIPVTFVLGF 84
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 156.762 bits (395), Expect = 1.501e-43
Identity = 106/349 (30.37%), Postives = 176/349 (50.43%), Query Frame = 1 
Query:  187 NERIK-FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENIL---IGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            N R+  F +LLLRW+GS++KLL+ +F  F V +  ++ +YR Y++ + N+K  FE + +Y NK A ++P+SF+LGF+V+ V+ RWW    S+PW  +      A      +   + +R T++RY NL+ +L +  +ST V +RF                P +                  D +V+  F   +   E R F+ +    NK  F  P +W   L  +A  +G I        + N + +F+S  S L  ++  ++PLVYTQV+ + VY+F ++ L+  Q +  +      +  Y P+F + +F  Y GW K+    INPFG D  D   +  +D NL++S
Sbjct:   11 NARLGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYR-YMLQE-NQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDR-LMHLVACNVHGADERGRLLRRTLMRYANLSALLILRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTPAERRKFDGLRSPHNK--FWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGPQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQVS 317
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 148.673 bits (374), Expect = 1.664e-39
Identity = 100/357 (28.01%), Postives = 171/357 (47.90%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQ-ALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y + ++      F KLLL+W+GS++KLL+ +F  + + Y+A+++  R  L  D  +K  FE + +Y N  A ++P+    GF+V+ V+ RWW    SIP  T     C  A      +   + +R T++RY NL+ +L +  +ST V +RF                P +                  D +V+  F   +  DE + F+ +    NK  +  P +W + L  +A  +G ++       L + +  ++ N   L  ++  +VPLVYTQV+ + VY+F ++ L+  Q +       G     Y P+F + +F  Y GW K+    INPFG D  D   + ++D NL++S
Sbjct:    5 YTNRVANARLCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSED--QKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIP--TPDRLMCAVAGTVHGVDERGRLLRRTLMRYANLSALLILRSVSTAVYKRF----------------PTM------------------DHVVEAGF---MTRDERKRFDGLRCSYNK--YWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPAQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 165.236 bits (417), Expect = 4.638e-44
Identity = 105/356 (29.49%), Postives = 183/356 (51.40%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            Y S ++    + F +LLLRW+GS++KLL+ +F+ F++ Y+ ++++YR+ L     +K  FE + IY ++ A  +P++F+LGF+V+ V+ RWW    ++PW  +  F   + +    E   + +R T+VRY+NL  +L    +ST V +RF                P +                  D +V+  F   +  +E +VFEN+     K  +  P++W + L  +A ++G I+      N+ N +  F++  + L  ++   +PLVYTQV+ + VYTF  + ++  Q +       G     Y P+F + +F  Y GW K+    INPFG D  D   + I+D NL++S
Sbjct:    5 YSSKVANATFLSFHRLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSE--QQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDE-YGRLLRRTLVRYINLTSLLIFRSVSTAVCKRF----------------PTI------------------DHVVEAGF---MTPEERKVFENIRSPHLK--YWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPAQGHPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 156.762 bits (395), Expect = 3.212e-41
Identity = 108/360 (30.00%), Postives = 176/360 (48.89%), Query Frame = 1 
Query:  157 ITMYLSAISLNER-IKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            +T+  +A   N R   F KLLL W+GS++K+L+ +F+ F V Y+AI++ YR +L  D  +K  FE + IY N  A ++P+SF+LGF+V+ ++ RWW    SIP   +        +  + E   + +R +++RY +L+ +L +  +ST V +RF                P +                  D +V+  F   +  +E + FE +    NK  +  P +W T L   A  +G I+       L   +  F+   S L  ++  +VPLVYTQV+ + VY+F +  L+  Q +       G     Y PIF + +F  Y GW K+    INPFG D  D   + ++D N ++S
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFVLYAAISITYRFFLYED--QKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDE-RGRLLRRSMMRYASLSALLILRSVSTAVFKRF----------------PTM------------------DHVVEAGF---MTREERKKFEGLHSPYNK--YWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQGYQGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVS 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 149.058 bits (375), Expect = 3.178e-38
Identity = 99/344 (28.78%), Postives = 167/344 (48.55%), Query Frame = 1 
Query:  202 FLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGS----YFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEIS 1221
            F  LLLRW+GS++KLL+ + I F++ Y  ++++Y M    D +++  FE + IY ++ A ++P+SF+L F+V+ V+ RWW    +IPW  + A      +   T+   +  R  ++RY+NL+ +L    +ST V +RF    TT  ++  L  S                                   +E+R FE +    NK  F  P MW   L  +A  +G I +      +   +   ++    L  ++  ++PLVYTQV  + VY+F ++ L+  Q +       G     Y P+F + +F  Y+GW K+    INPFG D  D   + ++D NL++S
Sbjct:   17 FFHLLLRWKGSIYKLLYRELIIFTLLYYFLSLVYYML---DNDQRRLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGHV-RGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRF---PTTEHLVQALMTS-----------------------------------EELRHFEELPSPHNK--FWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGYPGHDVDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVS 315
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000016290.1 (SMESG000016290.1)

HSP 1 Score: 848.966 bits (2192), Expect = 0.000e+0
Identity = 420/421 (99.76%), Postives = 421/421 (100.00%), Query Frame = 1 
Query:  163 MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 1425
            MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKM+KINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD
Sbjct:    1 MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMEKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 421
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000016290.1 (SMESG000016290.1)

HSP 1 Score: 761.525 bits (1965), Expect = 0.000e+0
Identity = 376/377 (99.73%), Postives = 377/377 (100.00%), Query Frame = 1 
Query:  295 MLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 1425
            MLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKM+KINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD
Sbjct:    1 MLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMEKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 377
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000016290.1 (SMESG000016290.1)

HSP 1 Score: 752.666 bits (1942), Expect = 0.000e+0
Identity = 372/373 (99.73%), Postives = 373/373 (100.00%), Query Frame = 1 
Query:  307 MYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 1425
            MYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKM+KINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD
Sbjct:    1 MYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMEKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNENILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEEKCCSKTYVDGHMFATHDEPDD 373
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000016290.1 (SMESG000016290.1)

HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0
Identity = 276/277 (99.64%), Postives = 277/277 (100.00%), Query Frame = 1 
Query:  163 MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQ 993
            MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKM+KINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQ
Sbjct:    1 MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMEKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQ 277
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000016298.1 (SMESG000016298.1)

HSP 1 Score: 499.975 bits (1286), Expect = 6.306e-175
Identity = 259/437 (59.27%), Postives = 321/437 (73.46%), Query Frame = 1 
Query:  166 YLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMYLIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIPWMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQRFIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLIMEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLFNMVQDFKSNLSNLAVHNEFNVPLVYTQXXXXXXYTFLISELLSEQIISNENI----------------LIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNLEISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPE-SFNVKKEEKCCSKTYVDGHMFATHDEPDD 1425
            YLSAISLNERIKFLKLLLRWQGSLWKLLW DF+WF   Y  IT+LYR+YLIHDP  K  FESIV Y+NKVA +VPLSFLLGFFVSTVLGRWW+IV SIPWMTKPAFTCQALI       CK+IRLTIVRYMNLAWILS+M LS KVK RF+I  T  K    +K     +   K   +R+KM KINSD +VKK FG LIME+E++VFEN E  S KP++I PLMW T+LIEK+++ G+I+S+ V  ++FN+VQ+F+ +L  L+V+NEFNVPLVYTQVIIIVVYTFLISE+ ++Q+I +  I                 + +Y P+F IFKF+IYMGWFK+GLSFINPFG + SDLPLDEILDYNLE+S+++A G+D Y+PEYL+ TF+D     +K  E FR  +P  +      +K  ++  V+  +F + DE  D
Sbjct:    8 YLSAISLNERIKFLKLLLRWQGSLWKLLWADFLWFICSYIGITLLYRLYLIHDPVNKGRFESIVTYMNKVAALVPLSFLLGFFVSTVLGRWWEIVMSIPWMTKPAFTCQALICGGDRNTCKNIRLTIVRYMNLAWILSLMNLSQKVKLRFLIPITEGK--KTIKMKMLKHEKPKPITIRQKMMKINSDVLVKKFFGTLIMEEEMKVFENFEKQSKKPTYIVPLMWATKLIEKSYKAGYIESERVFLHIFNLVQEFRGSLGTLSVYNEFNVPLVYTQVIIIVVYTFLISEIFTQQLIDHNLIHKKTLYQNSTFISITAALDNYLPVFGIFKFLIYMGWFKVGLSFINPFGREQSDLPLDEILDYNLEVSASVAPGDDLYFPEYLSDTFEDGSGDRFKIFESFRSALPRLNMISGGNDKAGNEKAVEMQIFNSSDEAVD 442
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST31.350e-4230.06bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST37.570e-4130.06bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST42.144e-4028.41bestrophin 4 [Source:HGNC Symbol;Acc:HGNC:17106][more]
BEST24.646e-3829.09bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST24.646e-3829.09bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-47.614e-3926.18Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-36.522e-3826.61Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-141.509e-3729.78Bestrophin homolog 14 [Source:UniProtKB/Swiss-Pro... [more]
best-232.322e-3628.16Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A... [more]
best-221.045e-3528.04Bestrophin homolog 22 [Source:UniProtKB/Swiss-Pro... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best11.460e-5231.58gene:FBgn0040238 transcript:FBtr0082183[more]
Best11.567e-5231.41gene:FBgn0040238 transcript:FBtr0337020[more]
Best13.288e-5231.41gene:FBgn0040238 transcript:FBtr0306023[more]
Best13.614e-5231.58gene:FBgn0040238 transcript:FBtr0114590[more]
Best21.772e-4728.47gene:FBgn0035696 transcript:FBtr0077010[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best46.543e-4430.52bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best41.634e-4330.32bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best15.769e-4229.07bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best24.386e-4029.56bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best21.088e-2128.69bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ifitm31.592e-4028.65interferon induced transmembrane protein 3 [Source... [more]
cyp2b68.142e-3929.38cytochrome P450 family 2 subfamily B member 6 [Sou... [more]
best12.186e-3828.49bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best12.324e-3828.49bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best14.568e-3828.49bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best33.165e-4129.49bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298][more]
Best12.518e-3828.37bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best26.602e-3829.09bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best26.602e-3829.09bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best26.602e-3829.09bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6H1V1|BEST3_MOUSE2.214e-4029.49Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=... [more]
sp|Q8N1M1|BEST3_HUMAN3.635e-4030.06Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1... [more]
sp|Q8NFU0|BEST4_HUMAN1.029e-3928.41Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2... [more]
sp|Q8NFU1|BEST2_HUMAN2.231e-3729.09Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1... [more]
sp|Q8BGM5|BEST2_MOUSE5.199e-3729.09Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267DQK54.258e-8235.32Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A267FRV11.527e-8135.73Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A267EEP43.896e-8135.11Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A267GVI25.952e-8135.82Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A267E3636.061e-8135.11Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best15.805e-4330.23bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best22.368e-4030.00bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best43.125e-3828.03bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best15.077e-3528.20bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST31.513e-1630.82bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best11.501e-4330.37bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best21.664e-3928.01bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
BEST34.638e-4429.49bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
best23.212e-4130.00bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
best13.178e-3828.78bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016290.10.000e+099.76SMESG000016290.1[more]
SMESG000016290.10.000e+099.73SMESG000016290.1[more]
SMESG000016290.10.000e+099.73SMESG000016290.1[more]
SMESG000016290.10.000e+099.64SMESG000016290.1[more]
SMESG000016298.16.306e-17559.27SMESG000016298.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30004531 ID=SMED30004531|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1502bp
TTGGCATTTACCTGATGCTCAATTCACAACACAGAATCAGTTGCACTGTG
CAATATGCTCAACGGTCTGTGGCCAAGGTCATTTTGTTCTGATTAAAGCA
CAACTGACAACGGTGAATCAAATCTGCTGCAAAAATCATCGAAATTGAAT
TTTGTTATCACCATGTATCTTTCCGCAATTTCGCTCAATGAACGAATCAA
ATTCTTGAAGCTTTTGCTCCGCTGGCAAGGCAGTCTATGGAAGTTACTCT
GGGTGGACTTTATATGGTTTTCAGTATTTTATTCAGCCATTACCATGTTA
TATCGAATGTACCTGATTCACGATCCAAATAAAAAGGAAGCGTTTGAATC
TATCGTCATTTATCTCAATAAAGTAGCTGGAATAGTTCCCCTATCCTTCC
TTTTGGGTTTTTTTGTGTCAACAGTACTTGGAAGATGGTGGAAGATCGTC
AACTCAATTCCTTGGATGACCAAACCGGCATTTACGTGTCAAGCTCTTAT
AACTGAAGACACGGAACCTTTGTGCAAGGATATTCGTTTGACTATCGTTC
GATATATGAACTTGGCTTGGATCCTCTCCGTCATGTACTTGAGTACCAAA
GTCAAGCAGAGATTCATTATAACGTCTACGACCAACAAAATTATCTCCTG
TTTAAAAGATTCGCCAAATCTTAATACAATTTCGAAAGGAAAAAATGTAC
GAAAAAAAATGGATAAAATCAACTCGGATGAAATAGTTAAAAAGCATTTT
GGGAAGTTGATTATGGAAGATGAAATAAGAGTATTTGAGAACGTTGAACA
TATGTCTAATAAACCTTCATTTATCACCCCCCTAATGTGGACAACGAGAT
TGATTGAAAAGGCTCACAGGGATGGGTTTATCAAATCACAGGGTGTTTGT
TTTAATCTGTTTAATATGGTTCAAGATTTTAAATCGAATTTAAGCAATCT
GGCAGTTCATAATGAATTTAACGTCCCTCTCGTGTACACTCAAGTAATAA
TAATCGTGGTCTACACATTCCTGATCAGTGAATTACTATCGGAACAAATA
ATATCAAATGAAAATATTCTCATCGGCTCTTACTTCCCAATATTTGCAAT
TTTTAAATTTATCATTTACATGGGTTGGTTCAAAATGGGTCTGAGCTTCA
TCAATCCGTTTGGTAGCGATCCAAGCGACCTGCCATTAGATGAAATTCTT
GATTACAACTTGGAAATATCATCGACAATCGCCTCTGGAGAGGATTTTTA
TTATCCAGAATATCTAACAAAAACCTTCAAGGATCCTGAGGATAGTCCAT
GGAAGCAATTGGAAAAATTCCGATTACTTGTTCCTGAATCTTTCAATGTT
AAGAAAGAAGAAAAATGTTGCAGCAAAACCTATGTTGACGGCCATATGTT
CGCTACTCATGATGAGCCAGATGACTGACTCGCAGTTTCATTGTCAAATT
TCGTGATGATGTAATATCATAATAATAAACTGTTATTATTATTGTTAAAA
AA
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protein sequence of SMED30004531-orf-1

>SMED30004531-orf-1 ID=SMED30004531-orf-1|Name=SMED30004531-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=422bp
MYLSAISLNERIKFLKLLLRWQGSLWKLLWVDFIWFSVFYSAITMLYRMY
LIHDPNKKEAFESIVIYLNKVAGIVPLSFLLGFFVSTVLGRWWKIVNSIP
WMTKPAFTCQALITEDTEPLCKDIRLTIVRYMNLAWILSVMYLSTKVKQR
FIITSTTNKIISCLKDSPNLNTISKGKNVRKKMDKINSDEIVKKHFGKLI
MEDEIRVFENVEHMSNKPSFITPLMWTTRLIEKAHRDGFIKSQGVCFNLF
NMVQDFKSNLSNLAVHNEFNVPLVYTQVIIIVVYTFLISELLSEQIISNE
NILIGSYFPIFAIFKFIIYMGWFKMGLSFINPFGSDPSDLPLDEILDYNL
EISSTIASGEDFYYPEYLTKTFKDPEDSPWKQLEKFRLLVPESFNVKKEE
KCCSKTYVDGHMFATHDEPDD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 12..350
e-value: 7.6E-62
score: 209.4
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 11..379
NoneNo IPR availableCDDcd06174MFScoord: 10..96
e-value: 0.00899644
score: 35.8654
NoneNo IPR availableTMHMMTMhelixcoord: 71..93
NoneNo IPR availableTMHMMTMhelixcoord: 301..323
NoneNo IPR availableTMHMMTMhelixcoord: 271..288
NoneNo IPR availableTMHMMTMhelixcoord: 28..50