cGMP-dependent protein kinase

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   ++D+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   ++D+ P DD SGWD DF
Sbjct:  230 FLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686          

Query: 1137 TVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR                     WF  FN + L   T+ PPIIP V SPTD  NF +   ++D+ P DD SGWD DF
Sbjct:   34 TANVIAAEAVTCLVIDRDSFKHLIG-GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR---------------------WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 382          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKD------------ANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXX----------------RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LK++PE+ + KI+D +  ++Y     I  +  + +  FI+AKG VK+T+     D                  + +  L +G++FG+  ++SD+   +   + A   D V C++++++ ++Q +              AN + ++E R  +   +  +L +   L +  L    +  S                    RVELV++ K+++  FA+K +RK  IV+ KQQ+HV  E+ IL ++ S FIV+LYRTFKD KY+YM++E CLGGELWSILR++  F++  ++F   CV  A  YLH   I+YRDLKPENL+LD  GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL  GHD + DFWSLGIL+YELL+G PPF       TY+L+L GI+ ++FPR I++  ++LI++LCR NP+ERLG    G+    KH W + FN + L  +++  P+  ++  P D   F +  P     P D++SGWD+DF
Sbjct:  280 FLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQ----------------PQLIKTLQKGEYFGEKALISDDVRSA--NIIAEEND-VACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF-DKYPPEKGMPPDELSGWDKDF 762          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKD------------ANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXX----------------RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LK++PE+ + KI+D +  ++Y     I  +  + +  FI+AKG VK+T+     D                  + +  L +G++FG+  ++SD+   +   + A   D V C++++++ ++Q +              AN + ++E R  +   +  +L +   L +  L    +  S                    RVELV++ K+++  FA+K +RK  IV+ KQQ+HV  E+ IL ++ S FIV+LYRTFKD KY+YM++E CLGGELWSILR++  F++  ++F   CV  A  YLH   I+YRDLKPENL+LD  GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL  GHD + DFWSLGIL+YELL+G PPF       TY+L+L GI+ ++FPR I++  ++LI++LCR NP+ERLG    G+    KH W + FN + L  +++  P+  ++  P D   F +  P     P D++SGWD+DF
Sbjct:  280 FLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQ----------------PQLIKTLQKGEYFGEKALISDDVRSA--NIIAEEND-VACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF-DKYPPEKGMPPDELSGWDKDF 762          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN----------------------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFP-RYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGN 2183
            FL  VSI +++ E+ + K+ D+M + +Y     I  Q  +    F++  G VK+T++      +  ++E             +  L++GD+FG+  L  E+ ++   +    A GVE + L+++++ +LI D  +                       I ++ RE+  Q T+K +++ + L +               RVELV +N D +KTFALK ++K  IV+ +QQ+H+  ERNI+++  +D+IV+LY+TF+D+K++YM++EVCLGGELW+ LR++  F+D  A+F+  CV+  L YLH + IVYRDLKPEN LL + GY KL DFGFAK++ SGR+TWTFCGTP+YV+PEIIL  GHD AAD+W+LGI I EL+ GRPPF AS   KTY L+L G+D +E P R I K A  L+KKLCR NP ERLG G  G+    KH WF  F+ + L  +T+ PPI+P+V +P D  NF N
Sbjct:   17 FLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ------IEGETEPRE----------IRVLNQGDFFGERALLGEEVRTANIIAQ--APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFG-----------RVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDN 465          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN----------------------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFP-RYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGN 2183
            FL  VSI +++ E+ + K+ D+M + +Y     I  Q  +    F++  G VK+T++      +  ++E             +  L++GD+FG+  L  E+ ++   +    A GVE + L+++++ +LI D  +                       I ++ RE+  Q T+K +++ + L +               RVELV +N D +KTFALK ++K  IV+ +QQ+H+  ERNI+++  +D+IV+LY+TF+D+K++YM++EVCLGGELW+ LR++  F+D  A+F+  CV+  L YLH + IVYRDLKPEN LL + GY KL DFGFAK++ SGR+TWTFCGTP+YV+PEIIL  GHD AAD+W+LGI I EL+ GRPPF AS   KTY L+L G+D +E P R I K A  L+KKLCR NP ERLG G  G+    KH WF  F+ + L  +T+ PPI+P+V +P D  NF N
Sbjct:   17 FLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ------IEGETEPRE----------IRVLNQGDFFGERALLGEEVRTANIIAQ--APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFG-----------RVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDN 465          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN----------------------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFP-RYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGN 2183
            FL  VSI +++ E+ + K+ D+M + +Y     I  Q  +    F++  G VK+T++      +  ++E             +  L++GD+FG+  L  E+ ++   +    A GVE + L+++++ +LI D  +                       I ++ RE+  Q T+K +++ + L +               RVELV +N D +KTFALK ++K  IV+ +QQ+H+  ERNI+++  +D+IV+LY+TF+D+K++YM++EVCLGGELW+ LR++  F+D  A+F+  CV+  L YLH + IVYRDLKPEN LL + GY KL DFGFAK++ SGR+TWTFCGTP+YV+PEIIL  GHD AAD+W+LGI I EL+ GRPPF AS   KTY L+L G+D +E P R I K A  L+KKLCR NP ERLG G  G+    KH WF  F+ + L  +T+ PPI+P+V +P D  NF N
Sbjct:   17 FLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ------IEGETEPRE----------IRVLNQGDFFGERALLGEEVRTANIIAQ--APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFG-----------RVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDN 465          

Query:  834 VSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN----------------------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFP-RYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGN 2183
            VSI +++ E+ + K+ D+M + +Y     I  Q  +    F++  G VK+T++      +  ++E             +  L++GD+FG+  L  E+ ++   +    A GVE + L+++++ +LI D  +                       I ++ RE+  Q T+K +++ + L +               RVELV +N D +KTFALK ++K  IV+ +QQ+H+  ERNI+++  +D+IV+LY+TF+D+K++YM++EVCLGGELW+ LR++  F+D  A+F+  CV+  L YLH + IVYRDLKPEN LL + GY KL DFGFAK++ SGR+TWTFCGTP+YV+PEIIL  GHD AAD+W+LGI I EL+ GRPPF AS   KTY L+L G+D +E P R I K A  L+KKLCR NP ERLG G  G+    KH WF  F+ + L  +T+ PPI+P+V +P D  NF N
Sbjct:    7 VSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ------IEGETEPRE----------IRVLNQGDFFGERALLGEEVRTANIIAQ--APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFG-----------RVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDN 451          

Query:  834 VSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN----------------------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFP-RYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGN 2183
            VSI +++ E+ + K+ D+M + +Y     I  Q  +    F++  G VK+T++      +  ++E             +  L++GD+FG+  L  E+ ++   +    A GVE + L+++++ +LI D  +                       I ++ RE+  Q T+K +++ + L +               RVELV +N D +KTFALK ++K  IV+ +QQ+H+  ERNI+++  +D+IV+LY+TF+D+K++YM++EVCLGGELW+ LR++  F+D  A+F+  CV+  L YLH + IVYRDLKPEN LL + GY KL DFGFAK++ SGR+TWTFCGTP+YV+PEIIL  GHD AAD+W+LGI I EL+ GRPPF AS   KTY L+L G+D +E P R I K A  L+KKLCR NP ERLG G  G+    KH WF  F+ + L  +T+ PPI+P+V +P D  NF N
Sbjct:    7 VSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQ------IEGETEPRE----------IRVLNQGDFFGERALLGEEVRTANIIAQ--APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFG-----------RVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDN 451          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +                  + ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:   15 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQ----------------QDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 471          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +                  + ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:  112 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQ----------------QDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 568          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +                  + ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:  112 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQ----------------QDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 568          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +    DT              ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:  286 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DT--------------QEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 742          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +    DT              ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:  438 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DT--------------QEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 894          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + + EE++ K+ D++ E HY+  + I  Q ++    FI++KG V +T+ +    T                  +L  L +GDWFG+     Q +   T   I A+ V C++++++++  LI    +D++N+  +          +   +S+L L D  ++ +LG GGFGRVELV++  +++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:  213 FLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT----------------PVYLRALGKGDWFGE--KALQGEDIRTANVIAAEAVTCLVIDRESFKHLI-GGLDDVSNKGYDDAGAKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 669          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + + EE++ K+ D++ E HY+  + I  Q ++    FI++KG V +T+ +    T                  +L  L +GDWFG+     Q +   T   I A+ V C++++++++  LI    +D++N+  +          +   +S+L L D  ++ +LG GGFGRVELV++  +++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:  228 FLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT----------------PVYLRALGKGDWFGE--KALQGEDIRTANVIAAEAVTCLVIDRESFKHLI-GGLDDVSNKGYDDAGAKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 684          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
             LK+V   + +PEE++ K+ D++ E HY     I  Q ++    FI++KG V +T+ +                   ++  +L  + RGD FG+     Q +   T   I A+ V C+++++D+Y  LI     D++N+  E          +   +S+L+L D  ++ +LG GGFGRVELV++  D+ KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR  PSERLG    G+    KH WF  FN D L   T+ PPIIP V S TD  NF +   +++D P DD SGWD DF
Sbjct:  211 LLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCP----------------GQEPVYLRSMGRGDSFGE--KALQGEDIRTANVIAAETVTCLVIDRDSYKHLI-GGLEDVSNKGCEDAEAKAKYEAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 667          

Query:  888 MIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            +I  HY+  + I  Q ++    FI++KG V +T+ +    T                  +L  L +GDWFG+     Q +   T   I A+ V C++++++++  LI   + D++N+  +          +   +S+L L D  ++ +LG GGFGRVELV++  +++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:   14 LINTHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT----------------PVYLRALGKGDWFGE--KALQGEDIRTANVIAAEAVTCLVIDRESFKHLIGGLD-DVSNKGYDDAGAKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 448          

Query:  900 HYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            HY+  + I  Q ++    FI++KG V +T+ +    T                  +L  L +GDWFG+     Q +   T   I A+ V C++++++++  LI   + D++N+  +          +   +S+L L D  ++ +LG GGFGRVELV++  +++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:    2 HYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGT----------------PVYLRALGKGDWFGE--KALQGEDIRTANVIAAEAVTCLVIDRESFKHLIGGLD-DVSNKGYDDAGAKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 432          

Query:  834 VSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            V   + +PEE+V K+ D++ E HY +   I  Q ++    FI++KG V +T+     D+   D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   + +L L D  ++ +LG GGFGRVELV++  D+ KTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:    4 VPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE----DSPGEDPI------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG-GLDDVSNKAYEDAEAKAKYEAEAAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 456          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE+V K+ D++ E HY +   I  Q ++    FI++KG V +T+     D+   D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   + +L L D  ++ +LG GGFGRVELV++  D+ KTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:  217 FLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE----DSPGEDPI------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 673          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE+V K+ D++ E HY +   I  Q ++    FI++KG V +T+     D+   D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   + +L L D  ++ +LG GGFGRVELV++  D+ KTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:  229 FLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE----DSPGEDPI------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE+V K+ D++ E HY +   I  Q ++    FI++KG V +T+     D+   D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   + +L L D  ++ +LG GGFGRVELV++  D+ KTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +++D P DD SGWD DF
Sbjct:  229 FLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE----DSPGEDPI------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFGNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDA-------YHQLIK-----DANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXX---------------XRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V +LK++PE  + KI D +  + Y  +  I  +  + +  FI++KG VK+T+    +                 + +++ +L +GD+FG+  ++SD+   +   + A G D VEC++++++        Y +L+K      AN  +++E R  ++    + L+  S    K    L    S                  GRVELV++ K+++  FALK ++K  IV+ +QQ+H+  E+NIL +  S FIV+LY TFKD KY+YM++E CLGGELWSILR++  F++  A+F +GCV  A  YLH + ++YRDLKPENLLLD  GY KL DFGFAK+I  G++TWTFCGTP+YVAPE+IL  GH  + DFWSLGIL+YELL+G PPF        Y+L+L GI+ IEF + I+K  ++LI++LCR NP+ERLG    G+    KH WF+ FN + L  +++  P+ P++  PTD   F +  P  ++ P D+VSGWD+DF
Sbjct:  306 FLKSVPLLKELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIISKGKVKVTQSTEGYK----------------EPQYIKFLEKGDYFGEKALISDDVRSA--NILAYG-DRVECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERRHAKSPVNERHLRAVSMELNKMKQTLARFPSASPFENLEIVTTLGVGGFGRVELVKV-KNENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKNITKRPEDLIRRLCRENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSYF-DSYPPDEEIPPDEVSGWDQDF 787          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +P+E++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +SD+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +P+E++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +SD+ P DD SGWD DF
Sbjct:  230 FLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686          

Query: 1137 TVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR                     WF  FN + L   T+ PPIIP V SPTD  NF +   +SD+ P DD SGWD DF
Sbjct:   34 TANVIAAEAVTCLVIDRDSFKHLIG-GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR---------------------WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 382          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKD------------ANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXX----------------RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LK++PE+ + KI+D +  ++Y     I  +  + +  FI+AKG VK+T+     D                  + +  L +G++FG+  ++SD+   +   + A   D V C++++++ ++Q +              A  + ++E R  +   +  +L +   L +  L    +  S                    RVELV++ K+++  FA+K +RK  IV+ KQQ+HV  E+ IL ++ S FIV+LYRTFKD KY+YM++E CLGGELWSILR++  F++  ++F   CV  A  YLH   I+YRDLKPENL+LD  GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL  GHD + DFWSLGIL+YELL+G PPF       TY+L+L GI+ ++FPR I++  ++LI++LCR NP+ERLG    G+    KH W + FN + L  +++  P+  ++  P D   F +  P     P D++SGWD+DF
Sbjct:  280 FLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQ----------------PQLIKTLQKGEYFGEKALISDDVRSA--NIIAEEND-VACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYF-DKYPPEKGVPPDEMSGWDKDF 762          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIK--DANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LK++PE+ + KI+D +  ++Y     I  +  + +  FI+AKG VK+T+     D                  + +  L +G++FG+  ++SD+   +   + A   D V C++++++ ++Q +   D             N+   KR  + S  S K    L         +V++    K+++  FA+K +RK  IV+ KQQ+HV  E+ IL ++ S FIV+LYRTFKD KY+YM++E CLGGELWSILR++  F++  ++F   CV  A  YLH   I+YRDLKPENL+LD  GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL  GHD + DFWSLGIL+YELL+G PPF       TY+L+L GI+ ++FPR I++  ++LI++LCR NP+ERLG    G+    KH W + FN + L  +++  P+  ++  P D   F +  P     P D++SGWD+DF
Sbjct:  280 FLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQ----------------PQLIKTLQKGEYFGEKALISDDVRSA--NIIAEEND-VACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVKV----KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYF-DKYPPEKGVPPDEMSGWDKDF 733          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   ++D+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +P+E++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +SD+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE----DSPSEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE++ K+ D++ E HY   + I  Q ++    FI++KG V +T+     D+ + D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   ++D+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTRE----DSPNEDPV------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + +PEE++ K+ D++ E HY   +    Q ++    FI++KG V +T+     D+ S D              FL  L +GDWFG+     Q +   T   I A+ V C+++++D++  LI    +D++N+  E          +   +++L L D  ++ +LG GGFGRVELV++  ++SKTFA+K ++K  IV+ +QQ+H+  E+ I+    SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF     ++D+ P DD SGWD DF
Sbjct:  215 FLKSVPTFQSLPEEILSKLADVLEETHYENEEYSIRQGARGDTFFIISKGKVNVTRE----DSPSEDPI------------FLRTLGKGDWFGE--KALQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDGFPEDNDEPPPDDNSGWDIDF 671          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E+ + KI D++ E HY     I  Q ++    FI++KG V++T +    DT              ++E+F+  L +GD+FG+            +    ADGV C++++++ ++QLI + + +I +   ++      K  +++  ++L DL ++ +LG GGFGRVELV+ N D S++FALKQM+K++IVE +QQ H+M E+ I+ + +  FIV+L++TFKD+KYLYM+ME CLGGELW+ILR+K  F+D   +F++ CV+ A  YLHSR I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL  GHD++AD+WSLG+L++ELL+G PPF  S   +TY+++L GID IEFPR I++ A NLIKKLCR NP+ERLGY   G+ +  KH WF  F    L + T+ PPI P V S  D  NF +  P+ +  P DDV+GWD+DF
Sbjct:  478 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ--DT--------------QEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD-EIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 934          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++V   KD+P E + K+ D +   HY + + I  Q ++    +I+AKG V++T+R+ T                  +E F+  ++RGDWFG+  L DE  ++   V +    GV+C++L +++Y QLI     D+ +  R+  ++T  KR +++ HL+LKDL ++ +LG GGFGRVELV+IN D+ ++FALKQ++K  IVE +QQ+HV++ER+IL + +SDF+V+LYRTFKDRKYLYM++E CLGGELW++LR+K  F+D   +F+  CV  ALSYLH R IVYRDLKPENLLLD  GYCKLTDFGFAKRIG G++TWTFCGTP+YV PE+IL  GHD++ADFWSLGIL++ELL+G PPF AS   KTY+++L GID +EFPR +S+ AQNLIKKLCR NP+ER+G G  G+++  +H WF  FN   +  +++ PP +PQV SP D  NF +  P   ++P DDVSGWD+DF
Sbjct:  252 FLRSVPAFKDLPAETLSKLADALEADHYPSGEYIIRQGAKGNTFYIIAKGAVEVTRRDST----------------TGEEVFIRNMNRGDWFGEKALKDEDVRTANIVVS-DPSGVDCLVLSRESYKQLI----GDLASFDRKYPDETAPKRAEEFRHLTLKDLYIVATLGVGGFGRVELVQINNDNQRSFALKQLKKQHIVETRQQEHVLNERDILAECNSDFVVKLYRTFKDRKYLYMLLECCLGGELWTVLRDKGHFDDSMTRFYMACVSEALSYLHRRGIVYRDLKPENLLLDSAGYCKLTDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLSADFWSLGILMFELLTGTPPFSASDPMKTYNIILKGIDAVEFPRRVSRNAQNLIKKLCRDNPTERIGVGRSGIVEVSQHLWFEGFNWGGVRSRSLKPPHLPQVASPKDASNF-DDYPPDPEQPPDDVSGWDKDF 704          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            FL++V   KD+P E + K+ D +   HY + + I  Q ++    +I+AKG V++T+R+ T                  +E F+  ++RGDWFG+  L DE  ++   V +    GV+C++L +++Y QLI     D+ +  R+  ++T  KR +++ HL+LKDL ++ +LG GGFGRVELV+IN D+ ++FALKQ++K  IVE +QQ+HV++ERNIL + +SDF+V+LYRTFKDRKYLYM++E CLGGELW++LR+K  F+D   +F+  CV  ALSYLH R IVYRDLKPENLLLD  GYCKLTDFGFAKRIG G++TWTFCGTP+YV PE+IL  GHD++ADFWSLGIL++ELL+G PPF AS   KTY+++L GID +EFPR +S+ AQNLIKKLCR NP+ER+G G  G+++  KH WF  FN   +  +++ PP +PQV SP D  NF
Sbjct:  252 FLRSVPAFKDLPVETLSKLADALEADHYPSGEYIIRQGAKGNTFYIIAKGAVEVTRRDST----------------AGEEVFIRNMNRGDWFGEKALKDEDVRTANIVVS-DPSGVDCLVLSRESYKQLI----GDLASFDRKYPDETAPKRAEEFRHLTLKDLYIVATLGVGGFGRVELVQINNDNQRSFALKQLKKQHIVETRQQEHVLNERNILAECNSDFVVKLYRTFKDRKYLYMLLECCLGGELWTVLRDKGHFDDSMTRFYMACVSEALSYLHRRGIVYRDLKPENLLLDSAGYCKLTDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLSADFWSLGILMFELLTGTPPFSASDPMKTYNIILKGIDAVEFPRRVSRNAQNLIKKLCRDNPTERIGVGRSGIVEVSKHLWFEGFNWGGVRSRSLKPPHLPQVASPKDASNF 683          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL +V   K++P+E +  + D++   HY   + I  Q ++    +I+AKG V++TKR    D+ + +S             FL  + RGDWFG+  LSDE  ++   +    ++GV+C++L +++Y QLI     D+    R+  + TT KR +++  L+L+DL ++ +LG GGFGRVELVRIN D++++FALKQ++K  IVE +QQ+HVM+ER+IL   + +FIV+LY+TFKDRKYLYM++E CLGGELW++LR+K  F+D   +F+ GCV+ AL+YLH R +VYRDLKPENLLLD  GYCKLTDFGFAKRIG G++TWTFCGTP+YV PE+IL  GHD++ADFWSLG+LI+ELL+G PPF+AS   KTY+++L GID ++FPR + + AQNLIKKLCR +PSERLG+G  G+++   H WF  FN   +  +++ PP +P++ SP D  NF +  P   ++P DDVSGWD+DF
Sbjct:  235 FLSSVPAFKELPDETLSNLADVLETDHYPDGEYIIRQGAKGNTFYIIAKGTVRVTKR----DSATGESV------------FLRNMGRGDWFGEKALSDEDVRTANIIVE-DSEGVDCLVLTRESYKQLI----GDLIILERKYSDDTTPKRSEEFRGLALRDLYIVATLGVGGFGRVELVRINNDNNRSFALKQLKKQHIVETRQQEHVMNERSILADTNCEFIVKLYKTFKDRKYLYMLLECCLGGELWTVLRDKGHFDDSMTRFYIGCVVEALTYLHRRGVVYRDLKPENLLLDSTGYCKLTDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLSADFWSLGVLIFELLTGTPPFVASDPMKTYNIILKGIDAVDFPRRVGRNAQNLIKKLCRDSPSERLGFGRGGVMEVAHHVWFEGFNWAGVKSRSLTPPFLPKISSPVDASNF-DEYPPDAEQPPDDVSGWDKDF 687          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL +V   K++P+E +  + D++   HY   + I  Q ++    +I+AKG V++TKR    D+ + +S             FL  + RGDWFG+  LSDE  ++   +     +GV+C++L +++Y QLI     D+    R+  + TT KR +++  L+L+DL ++ +LG GGFGRVELVRIN D++++FALKQ++K  IVE +QQ+HVM+ER+IL   + +FIV+LY+TFKDRKYLYM++E CLGGELW++LR+K  F+D   +F+ GCV+ AL+YLH R +VYRDLKPENLLLD  GYCKLTDFGFAKRIG G++TWTFCGTP+YV PE+IL  GHD++ADFWSLG+LI+ELL+G PPF+AS   KTY+++L GID ++FPR + + AQNLIKKLCR +PSERLG+G  G+++   H WF  FN   +  +++ PP +P++ SP D  NF +  P   ++P DDVSGWD+DF
Sbjct:  214 FLSSVPAFKELPDETLSNLADVLETDHYPDGEYIIRQGAKGNTFYIIAKGTVRVTKR----DSATGESV------------FLRNMGRGDWFGEKALSDEDVRTANIIVE-DPEGVDCLVLTRESYKQLI----GDLIILERKYSDDTTPKRSEEFCGLALRDLYIVATLGVGGFGRVELVRINNDNNRSFALKQLKKQHIVETRQQEHVMNERSILADTNCEFIVKLYKTFKDRKYLYMLLECCLGGELWTVLRDKGHFDDSMTRFYIGCVVEALTYLHRRGVVYRDLKPENLLLDSTGYCKLTDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLSADFWSLGVLIFELLTGTPPFVASDPMKTYNIILKGIDAVDFPRRVGRNAQNLIKKLCRDSPSERLGFGRGGVMEVAHHVWFEGFNWAGVKSRSLTPPFLPKISSPVDASNF-DEYPPDAEQPPDDVSGWDKDF 666          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL +V   K++P+E +  + D++   HY   + I  Q ++    +I+AKG V++TKR    D+ + +S             FL  + RGDWFG+  LSDE  ++   +     +GV+C++L +++Y QLI     D+    R+  + TT KR +++  L+L+DL ++ +LG GGFGRVELVRIN D++++FALKQ++K  IVE +QQ+HVM+ER+IL   + +FIV+LY+TFKDRKYLYM++E CLGGELW++LR+K  F+D   +F+ GCV+ AL+YLH R +VYRDLKPENLLLD  GYCKLTDFGFAKRIG G++TWTFCGTP+YV PE+IL  GHD++ADFWSLG+LI+ELL+G PPF+AS   KTY+++L GID ++FPR + + AQNLIKKLCR +PSERLG+G  G+++   H WF  FN   +  +++ PP +P++ SP D  NF +  P   ++P DDV+GWD+DF
Sbjct:  235 FLSSVPAFKELPDETLSNLADVLETDHYPDGEYIIRQGAKGNTFYIIAKGTVRVTKR----DSATGESV------------FLRNMGRGDWFGEKALSDEDVRTANIIVE-DPEGVDCLVLTRESYKQLI----GDLIILERKYSDDTTPKRSEEFRGLALRDLYIVATLGVGGFGRVELVRINNDNNRSFALKQLKKQHIVETRQQEHVMNERSILADTNCEFIVKLYKTFKDRKYLYMLLECCLGGELWTVLRDKGHFDDSMTRFYIGCVVEALTYLHRRGVVYRDLKPENLLLDSTGYCKLTDFGFAKRIGFGKKTWTFCGTPEYVPPEVILNKGHDLSADFWSLGVLIFELLTGTPPFVASDPMKTYNIILKGIDAVDFPRRVGRNAQNLIKKLCRDSPSERLGFGRGGVMEVAHHVWFEGFNWAGVKSRSLTPPFLPKISSPVDASNF-DEYPPDAEQPPDDVTGWDKDF 687          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   + + EE++ K+ D++ E HY   + I  Q ++    FI++KG V +T+ +   DT                  +L  L +GDWFG+     Q +   T   I AD V C+++++D++  LI    +D++++  E          +   +S+L L D  ++ +LG GGFGRVELV++  +++KTFA+K ++K  IV+ +QQ+H+  E++I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NPSERLG    G+    KH WF  FN + L   T+ PPIIP V SPTD  NF +   +S+D P DD SGWD DF
Sbjct:  204 FLKSVPTFQGLAEEILSKLADVLEETHYDDGEYIIRQGARGDTFFIISKGKVNVTREDSPSDT----------------PVYLRALGKGDWFGE--KALQGEDIRTANVIAADAVTCLVIDRDSFKHLI-GGLDDVSSKGYEDAGAKAKYEAENAFFSNLKLADFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKHIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPDVSSPTDTSNFDSFPEDSEDPPPDDNSGWDTDF 660          

Query: 1395 LKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            +K ++K  IV+ +QQ+H+  E+ I+ +   DFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F+D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR  PSERLG    G+    KH WF  FN + L   T+ PPIIP V S TD  NF +   +++D P DD SGWD DF
Sbjct:    1 MKILKKRHIVDTRQQEHIRSEKLIMQEASPDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVTSATDTSNFDSFPEDNEDPPPDDNSGWDGDF 283          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANN------------DINNEIREKRNQTTV---------------KRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LKD+PEE + KIVD +   ++   + I  +  +    FI+AKG V +T+    +                     +  L  GD+FG+  L  E  +S   +     +  +C+++++D ++Q++                  IN+E R    Q+ +               K  +  S   L+ L ++ +LG GGFGRVELV++  +D+  FALK ++K  IV+ +QQ+H+  E+NIL Q + +FIVRL+RTF+D KY+YM++EVCLGGELWS+LR+ + F +  A+F  GCV+ A  YLH   IVYRDLKPENLLLD  GY K+TDFGFAKRIG G++TWTFCGTP+YVAPE+I+  GHD  AD WSLGILI+ELL G PPF  S   K Y +VL GI+ ++ P+ ISK  ++LI++LC+ NP+ERLG    G+I   KH WF  FN + L  + +  P+  ++  P D  +F ++ P   +EP D++SGWD+DF
Sbjct:  289 FLRSVSLLKDLPEEKLAKIVDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQSTEGYSE----------------PLEIKILGVGDYFGEKALISEDVRSANIIAK--ENDTQCLVVDRDNFNQMVGTYEELQAYLREYVEQLSINDERRIAATQSPLYERSPQAAELRSLHEKAARLSSCSFLQQLQIIATLGMGGFGRVELVKLKNEDT-AFALKCIKKKHIVDTRQQEHIYSEKNILQQTNCNFIVRLFRTFRDEKYVYMLLEVCLGGELWSVLRDMSFFEEATARFCIGCVLEAFDYLHGMGIVYRDLKPENLLLDAEGYVKMTDFGFAKRIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFSGSDPIKIYTMVLHGIEKVDIPKRISKRPEDLIRRLCKLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLASPLRRELNGPLDHSHF-DMFPPELEEPPDELSGWDKDF 770          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+L  +PE+ + KIVD +  ++Y     +  +  +    +I+A+G VK+T+     +                + + +  L +GD+FG+  ++SD+   +         DGVEC++++++ + Q +        +E++        K LQ Y     +D     +           V++ K+++ TFALK ++K  IV+ +Q++H+  ER IL + +S FIV++YRTFKD KY+YM++E CLGGE+WS+LR++  F +  A+F  GCV  A  YLH++ I+YRDLKPENL+LD  GY KL DFGFAK++  G++TWTFCGTP+YVAPEIIL  GH ++ DFW+LGILI+ELL+G PPF  S    TY  +L G++ ++FP+ ISK   +LI+KLC+ NPSERLG    G++   KH WF+ F+   L  +T+N P+  +V  PTD   F N  P  D+ P D++SGWD DF
Sbjct:  287 FLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHE----------------EPQVINTLQKGDYFGEKALISDDVRSANIIADE---DGVECLVIDRETFTQTV-----GTFDELK--------KYLQGYVETLARDDKKRNAKWFLIAVCSSQVKV-KNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDN-YPPEDEIPPDEISGWDMDF 728          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKD---------------ANNDINNEIREKRNQT------TVKRLQQYXXXXXXXXXXXXXXXXXXXX-----RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+L  +PE+ + KIVD +  ++Y     +  +  +    +I+A+G VK+T+     +                + + +  L +GD+FG+  ++SD+   +         DGVEC++++++ + Q +                 A +D     +   + T      ++ R+Q         L           G     RVELV++ K+++ TFALK ++K  IV+ +Q++H+  ER IL + +S FIV++YRTFKD KY+YM++E CLGGE+WS+LR++  F +  A+F  GCV  A  YLH++ I+YRDLKPENL+LD  GY KL DFGFAK++  G++TWTFCGTP+YVAPEIIL  GH ++ DFW+LGILI+ELL+G PPF  S    TY  +L G++ ++FP+ ISK   +LI+KLC+ NPSERLG    G++   KH WF+ F+   L  +T+N P+  +V  PTD   F N  P  D+ P D++SGWD DF
Sbjct:  287 FLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHE----------------EPQVINTLQKGDYFGEKALISDDVRSANIIADE---DGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELVKV-KNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPKKISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDN-YPPEDEIPPDEISGWDMDF 767          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            RV+LV++ KD   TFALK ++K  +VE++QQ+HV  E+ IL +    FIVR YRTF+D+K+++++ME CLGGELWS+LR+   F ++ A+F   CV+ AL+YLH+R I+YRDLKPENLLLD RGY K+ DFGFAK++  GR+ WTFCGTP+YV PE+I+  GHD  AD W+LG+L+YELL+G PPF  +   KTY+ +L G++ + FP  + K A+++I++LCR NPSERLG    G+    KH WF  F+ + L    +  P+  +V  PTD  NF +  PE  D P D+ SGWD DF
Sbjct:   47 RVQLVKL-KDSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVRFYRTFRDQKFVFLLMEACLGGELWSVLRDSGGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPNEVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNF-DWFPEDLDVPPDETSGWDHDF 343          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            RV+LV++ KD   TFALK ++K  +VE++QQ+HV  E+ IL +    FIVR                   GG           F ++ A+F   CV+ AL+YLH+R I+YRDLKPENLLLD RGY K+ DFGFAK++  GR+ WTFCGTP+YV PE+I+  GHD  AD W+LG+L+YELL+G PPF  +   KTY+ +L G++ + FP  + K A+++I++LCR NPSERLG    G+    KH WF  F+ + L    +  P+  +V  PTD  NF +  PE  D P D+ SGWD DF
Sbjct:   11 RVQLVKL-KDSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVR-------------------GG-----------FQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPNEVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNF-DWFPEDLDVPPDETSGWDHDF 277          

Query: 1392 ALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            +LK  ++T++V+ KQ +H ++E+ IL  +   F+VRL  +FKD   LYM++E   GGE++S LR   RF++  ++F++  ++ A  YLHS  ++YRDLKPENLL+D +GY ++TDFGFAKR+    RTWT CGTP+Y+APEIIL  G++ A D+W+LG+LIYE+ +G PPF A    + Y+ ++ G   + FP + S + ++L++ L + + ++R G    G+     H WFS  +   +  + +  P IP+   P D  NF
Sbjct:    8 SLKATKRTKVVKLKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNF 265          

Query: 1356 LVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQ-VDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKR-IGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            L+  +K D   +A+K M+K+ I++ K++ H+M ERN+L++ V   F+V L+ +F+    LY +M+   GGEL+  L+ +  F +  AQF++  + +A+ YLHS  IVYRDLKPEN+LLD++G+  LTDFG  K  I     T TFCGTP+Y+APE++    +D   D+W LG ++YE+L G PPF +  + + Y+ +L     ++     +  A ++++ L   +P +RLG     +++   H +FS  N ++L  + +  P  P V  P D  NF
Sbjct:  107 LLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESIL--HQPLQLRPCTTNAAISVLEGLLHKDPHQRLG-ATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNF 379          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHS-RQIVYRDLKPENLLLDHRGYCKLTDFGFAKR-IGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            +V LVR  K   + +A+K ++K  IV   +  H + E  +L      F+  L  +F+    L  +ME   GGEL+  L  +  F++   +F+   +++AL YLH+ + +VYRDLK ENL+LD  G+ K+ DFG  K  I  G    TFCGTP+Y+APE++  + +  A D+W LG+++YE++ GR PF      K ++L+L  ++ I FPR +S +A+ L+  L + +P +RLG GV+   +  +HS+F+     ++ D+ M PP  PQV S TD   F
Sbjct:  163 KVILVR-EKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYF 438          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGS 2156
            RV LVR +  + + +A+K ++K ++V+ KQ +H   ER +L  V+  F++R++ TF+D + ++M+M+   GGEL+S+LR+  RF +  A+F++  VI AL YLH+  I+YRDLKPEN+LLD  G+ K+TDFGFAK + +   TWT CGTPDY+APE+I    ++ + D+WSLG+LIYE+L+G  PF  +T  KTY+ +L G   + +P Y   +  +L+ KL  ++ + R+G    G      H WFS    + LL + +  P  P + S
Sbjct:   83 RVHLVR-SVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQT--VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG--KVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITS 347          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQV 2150
            RV L+R N +  + +ALK ++K  IV+ KQ +H   ER +L  V   FI+R++ TF+D + ++M+M+   GGEL+S+LR+  RF +  A+F++  V  AL YLHS+ I+YRDLKPEN+LLD  G+ K+TDFGFAK +     T+T CGTPDY+APE++    ++ + D+WS G+LIYE+L+G  PF  S   KTY+ +L     ++FP +   +AQ+L+KKL   + SERLG    G      H WF+    ++LL + +  P  P +
Sbjct:  101 RVHLIRSNHN-GRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNA--ELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPI 363          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQV 2150
            RV L+R ++ + + +A+K ++K  +V  KQ +H   ER +L  V   FI+R++ TF+D + ++M+M+   GGEL+S+LR+  RF +  A+F++  V  AL YLHS+ I+YRDLKPEN+LLD  G+ K+TDFGFAK +     T+T CGTPDY+APE++    ++ + D+WS GILIYE+L+G  PF  S   KTY+ +L     + FP + +++ ++L+ +L   + S+RLG    G      H WF     ++LL + +  P  P +
Sbjct:  100 RVHLIR-SRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA--ELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPI 362          

Query: 1371 KDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAK-RIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            KD  K +ALK +RK+ IV   +  H + ER +L +VD  FIV L  +F+  + LY ++    GGEL+  L+++ RF+   A+F++  ++ AL  LH   +VYRDLKPEN+LLD++G+  L DFG  K  +    +T TFCGTP+Y+APE++L  G+  A D+W+LG+L+YE+L+G PP+    + K Y  +L   + + FP    ++A++L+  L   +P+ RLGY   G  +   H +FS  +   LL +   PP  P V +  D  NF
Sbjct:  367 KDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKIL--QEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYN--GADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNF 632          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAK-RIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            +V  VR  KD  K +ALK +RK  IV   +  H + ER +L +VD  FIV L  +F+  + LY+++    GGEL+  L+ + RF+   ++F+   ++ AL  LH   ++YRDLKPEN+LLD++G+  L DFG  K  +    +T TFCGTP+Y+APEI+L  G+    D+W+LGIL+YE+++G PP+    +   Y  +L     + FP      A++L+  L   +PS RL  GV G  +   H +F + +  +LL +   PP  P V S  D  NF
Sbjct:  357 KVMQVR-KKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKIL--QQPLLFPDGFDPAAKDLLIGLLSRDPSRRL--GVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANF 629          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKR-NLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLI---KDANNDINNEIREKRNQTTVKRLQ----QYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++V++LKD+ E  + KI D++ E  Y   + I  Q ++    FI+  G V +T+R N+  D +   +                 LS+G +FG+  L  E  ++   +   G  GV C++L+++A+ Q I    D   D  ++ +   +  T   L+    +++++ L+DL ++ +LG GGFGRVELV++   D +TFALK ++K  IVE +QQDH+M E+ I+++ +S FIVRL++TFKD+KYLYM++EVCLGGELW+ILR++  F+D   +F+ GCVI A  YLHS+ IVYRDLKPENLLLD  GYCKL DFGFAK+IG GR+TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL+YELL+G PPF  +   KTY+++L GID I+FPR I++ A  LIKKLCR NP ERLGY   GL    KH WF  FN D L  + +N PI P++ SP D  NF +  P  DD P DD++GWD+DF
Sbjct:  200 FLRSVNLLKDLAESYLLKIADVIEETFYEEGEYIIRQGARGDTFFIIKSGNVDITQRTNVHSDPVHVRN-----------------LSKGAYFGEKALKGEDLRTANCIA--GKGGVTCLVLDREAFVQFIGNLDDIQRDQYDDSQRGVDPQTASHLRAQQDEFANVRLEDLTVVKTLGIGGFGRVELVQV-AGDKRTFALKTLKKHHIVETRQQDHIMSEKKIMMESNSPFIVRLHKTFKDKKYLYMLLEVCLGGELWTILRDRGSFDDSTTRFYVGCVIEAFQYLHSKGIVYRDLKPENLLLDGHGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFSGTDPMKTYNIILKGIDMIDFPRKITRNAHALIKKLCRDNPVERLGYQKGGLKDIMKHKWFDGFNWDGLRSRKLNSPIAPKIKSPVDASNF-DDYPADDDIPPDDMTGWDKDF 661          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGAD-GVECIILEKDAYHQLIKDANN----DINNEIREKRNQTTV-----KRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHS----WF------------SNFNADELLDQTMNPPIIP-----QVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V +LK++P   + K+ D++    Y A   I  +N +    +I+ KG  ++T+R                   +   + +  L +GD+FG+  +LS+++     T   I  + GVEC+++++  +  +I + +     D  +E R  +    V     K  ++++ L+L+DL ++ +LG+GGFGRVELV        T+ALK ++K  I++ +QQ+HV  E+ IL++ +S FI ++YRTFKDRKY+YM++E CLGGELW+ILR++  F D  A+F   CV+    YLHS+ IVYRDLKPENLLLD +GY KL DFGFAK+IGSGR+TWTFCGTP+YVAPEIIL  GHD+++D+WSLGILI+ELL+G PPF +S   KTY+++L G+D +EFP+ I +  QNLIK+LC+ NP ERLGY  +GL    KH     WF            SN     L+  T++    P     +V S TD  NF +V  +  D P D++SGWD +F
Sbjct:  177 FLKSVPLLKELPNAELSKLADVLEVDFYHAGDYIIRENERGDTFYIITKGSARVTQR----------------IEGQTGPKEIRKLQKGDYFGEKALLSEDRR----TANVIAEENGVECLVVDRTVFMTVIGNMDELREKDYGDEKRGAKRTLDVPEEERKVSKEFADLTLEDLEVVATLGTGGFGRVELV--------TYALKCLKKKHILDTRQQEHVYSEKRILMETNSPFICKIYRTFKDRKYVYMLLEACLGGELWTILRDRGTFEDATARFCIACVVEGFEYLHSKGIVYRDLKPENLLLDAKGYVKLVDFGFAKKIGSGRKTWTFCGTPEYVAPEIILNKGHDLSSDYWSLGILIFELLTGSPPFSSSDPMKTYNIILRGLDMVEFPKRIGRNPQNLIKRLCKDNPVERLGYQKDGLSDIKKHKYVVPWFPLAGTHRRDPRTSNQTRFWLMTTTLSFKTSPIYLLIRVESSTDYSNF-DVYSKDMDIPPDEMSGWDENF 654          

Query: 1347 RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYI-SKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            RV L R ++   + +ALK M  + ++  KQ +HV +E+NIL+ ++  FIV L  T  D+ +LYM++E   GGEL++ LR   RFN+    FF   +++A+ YLH   IVYRDLKPEN+LLD  G+ KLTDFGFAK +    +TWT CGTP+Y+APEII   GH+ A D+W+LGILIYE+L G PPF        Y+ +L G   +E+P+++ +  A++LIKKL   + + RLG    G      H WF   + + +L + + PPI P++  P D  NF
Sbjct:   31 RVLLAR-DRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKEVHD--KTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKILSG--KVEWPKHMDNTSAKDLIKKLLVHDRTRRLGSMKNGSEDVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNF 303          

Query: 1347 RVELVRINKDDSKT--FALKQMRKTRIVEA-KQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKR-IGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFK-HSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            +V LV+ N   SK   FA+K ++K  I+ + K   H   ERNIL  V   FIV L   F+    LY+++E   GGEL+  L  +  F +  A F+   +  AL +LH + IVYRDLKPEN+LLD  G+ KLTDFG  K  I     T TFCGT +Y+APEI+  SGH  A D+WSLG L+Y++L+G PPF A    KT D +L G   +  P Y++ EA++ I+KL + +P  RLG G+ G     K HS+F +   ++LL + + PP  P +    D   F
Sbjct:   78 KVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKG--KLIIPPYLTPEAKDFIRKLLKRHPQARLG-GMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQF 356          

Query: 1368 NKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQ-VDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKR-IGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNF 2177
            NK + K +A+K + K+ I +  +  H+M ERN+L+Q V   F+V L+ +F+ +  LY +++   GGEL+  L+ +  F +  A+F++  + +A+ YLH  QI+YRDLKPEN+LLD +G+  LTDFG  K  I     T TFCGTP+Y+APE++    +D + D+W LG ++YE++ G PPF +   ++ YD +L     +     IS+ A+++++ L + + ++RLG G         HS+F + N  +L+ + + PP  P V    D  +F
Sbjct:   93 NKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNIL--HKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHF 362          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLI---KDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V    D+ E+++ K+ D++ E HYA  + I  Q ++    FI++KG V +T+ +L                   +  +L  L +GDWFG+     Q +   T + I A+ V C+++++D++  LI   +D ++  +++   K           +  L+L D  ++ +LG GGFGRVELV++  D++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL++ELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NP ERLG    G+    KH WF  FN + L   T+ PPIIP V SP D  NF +   +++D P DD SGWD DF
Sbjct:  228 FLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP----------------NGEPVYLRSLGKGDWFGE--KALQGEDIRTASVIAAEAVTCLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKYEAENAF--FFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDDNSGWDVDF 684          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQ--YXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQV 2150
            FLK+V    D+ E+++ K+ D++ E HYA  + I  Q ++    FI++KG V +T+ +L                   +  +L  L +GDWFG+     Q +   T + I A+ V C+++++D++  LI     D++++  +  +       +   +  L+L D  ++ +LG GGFGRVELV++  D++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL++ELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NP ERLG    G+    KH WF  FN + L   T+ PPIIP V
Sbjct:  212 FLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP----------------NGEPVYLRSLGKGDWFGE--KALQGEDIRTASVIAAEAVTCLVIDRDSFKHLI-GGLEDVSSKGHDDADAKAKYEAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNV 637          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLI---KDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQV 2150
            FLK+V    D+ E+++ K+ D++ E HYA  + I  Q ++    FI++KG V +T+ +L                   +  +L  L +GDWFG+     Q +   T + I A+ V C+++++D++  LI   +D ++  +++   K           +  L+L D  ++ +LG GGFGRVELV++  D++KTFA+K ++K  IV+ +QQ+H+  E+ I+ +  SDFIVRLYRTFKD KYLYM+ME CLGGELW+ILR++  F D   +F++ CV+ A +YLHS+ I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL  GHD++AD+WSLGIL++ELL+G PPF      KTY+++L GID IEFP+ I+K A NLIKKLCR NP ERLG    G+    KH WF  FN + L   T+ PPIIP V
Sbjct:  228 FLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLP----------------NGEPVYLRSLGKGDWFGE--KALQGEDIRTASVIAAEAVTCLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKYEAENAF--FFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNV 653          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD--ILSDEQSKSPYTVTAIGAD-GVECIILEKDAYHQLIKDANN----------DINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXX-----------------RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+L ++P++ + KIVD +  ++Y   + I  +  + +  +I+A+G VK+T+                     +  + +  L +GD+FG+  ++SD+      +   I  D GVEC++++++ + Q + + N            ++ + +++  + +V R Q  S       +                            RVELV++  +D  TFALK ++K  +VE KQ++H+  ER IL +  S FIVRLYRTFKD KY+YM++E CLGGE+WS+LR++  F+D  A+F  GCV  A  YLH + ++YRDLKPENLLLD  GY KL DFGFAK+I SG++TWTFCGTP+YVAPEIIL  GH+ + DFW+LGIL++ELL+G PPF  S     Y  +L GI+ ++FP+ ISK  ++LI+KLCR NPSERLG    G+    KH WF+ FN + L  +T+  P+  ++  P D   F +  P  +D P D++SGWD DF
Sbjct:  288 FLRSVSLLANLPDDKLSKIVDCLEVEYYDKGEYIIREGEEGSTFYIIAQGKVKVTQ----------------TTEAHKLPQIINALQKGDYFGEKALVSDDVR----SANIIADDNGVECLVIDRETFDQTVGNFNELQKHLQGYVASLDRDDKKRHLKKSVSRHQSQSLSPGFMQLKDMVSLFTSSRPFHHLEVIATLGVGGFGRVELVKVKGEDV-TFALKAIKKKHVVENKQEEHIHSERRILAEARSPFIVRLYRTFKDSKYVYMLLEACLGGEVWSLLRDRGSFDDPTAKFCIGCVTEAFEYLHRKGVLYRDLKPENLLLDMEGYVKLVDFGFAKKIRSGQKTWTFCGTPEYVAPEIILNKGHNFSVDFWALGILVFELLTGSPPFSGSDQMTIYTFILKGIEKMDFPKMISKRPEDLIRKLCRRNPSERLGNLKNGITDIKKHRWFTGFNWEGLKARTLASPLKRELKGPMDHSYF-DSYPPDEDSPPDELSGWDEDF 769          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKD---------------ANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXX-----------RVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++VS+LK +PEE +G+IVD +  +++   + I  +  +    FI+AKG V +T+ +  F                     +  L  GD+FG+  L  E  +S   +     +  +C+++++D ++Q++                 + +D          Q+     Q+ S L  +   +  +                  RVELV++ KD+  TFALK ++K  +V+ +QQ H+  E+ IL Q +S FI+RL+RTF+D KY+YM++EVCLGGELW++LR+ + F +  A+F  GCV+ A  YLHS  I+YRDLKPENLLLD  GY K+ DFGFAK+IG GR+TWTFCGTP+YVAPE+I+  GHD  AD WSLGIL++ELL+G PPF  S   K Y +VL GID ++FP+ I K   +LI++LC+ NP ER+G    G++   KH WF  FN + L  + +  P+  ++  P D  NF ++ P + +E  D++SGWD+DF
Sbjct:  288 FLRSVSLLKQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIAKGQVTVTQSSEGFTQPQE----------------IKTLGVGDYFGERALISEDVRSANIIC--NENDTQCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDERRHFLPHSQQSDSPEAQELSRLRERTARIPANQPFQELEVIATLGMGGFGRVELVKL-KDEESTFALKCIKKKHVVDTRQQQHIYSEKKILQQTNSSFIIRLFRTFRDNKYIYMLLEVCLGGELWTVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAKQIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIYTMVLHGIDRVDFPKRIGKRPDDLIRRLCKLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRGPMDHSNF-DMFPPNSEEAPDELSGWDKDF 768          

Query:  672 MVVKQLDIENPLSRSNSTXXXXXXXXXXXXXXXXDSKYPISNYCNDCREWFLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            MVVKQLDIENPLSRSNSTRSVRRKKKKGIVRKRSDSKYPISNYCNDCREWFLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSE+ELKEVNEEDEEFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYSHLSLKDLVLLGSLGSGGFGRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNF ADELLDQTMNPPIIPQVGSPTDRGNFGNVKPESDDEPDDDVSGWDRDF
Sbjct:    1 MVVKQLDIENPLSRSNSTRSVRRKKKKGIVRKRSDSKYPISNYCNDCREWFLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSESELKEVNEEDEEFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYSHLSLKDLVLLGSLGSGGFGRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFKADELLDQTMNPPIIPQVGSPTDRGNFGNVKPESDDEPDDDVSGWDRDF 524          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRL---QQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E  +GKI  ++ E HYA    I  Q ++    FI++ G V++T++N   DT   +              F+  + RG+WFG+  L DE  ++   + A  A GV+C++L++++Y QLI D  + +     +  N +  + L   ++Y +L+LKDLV++ +LG GGFGRVELV+I  +  KT+ALKQ++K  IVE +QQ+H+M+ERNIL  V SDFIVRL+RTFKDRK+LYM+MEVCLGGELWSILR+++ F++   +F++ CVI AL YLHSR IVYRDLKPENLLLD++G+CK+TDFGFAK+IG GR+TWTFCGTP+YVAPEIIL  GHD  AD WSLGIL++ELL+G PPF A    K Y+++L GID IEFP+ ISK+AQNLIKKLCR NP+ER+GYG  G+ +C KH W  +FN D LL  T+ PPI+PQ+ SPTD  NF +  P   + P DD+SGWDRDF
Sbjct:  220 FLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQ-------------FIRQMQRGEWFGEKALKDEDLRTANIIAADPA-GVDCLVLDRESYIQLIGDLTS-LQRTYEDGVNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 681          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRL---QQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V I KD+ E  +GKI  ++ E HYA    I  Q ++    FI++ G V++T++N   DT   +              F+  + RG+WFG+  L DE  ++   + A  A GV+C++L++++Y QLI D  + +     +  N +  + L   ++Y +L+LKDLV++ +LG GGFGRVELV+I  +  KT+ALKQ++K  IVE +QQ+H+M+ERNIL  V SDFIVRL+RTFKDRK+LYM+MEVCLGGELWSILR+++ F++   +F++ CVI AL YLHSR IVYRDLKPENLLLD++G+CK+TDFGFAK+IG GR+TWTFCGTP+YVAPEIIL  GHD  AD WSLGIL++ELL+G PPF A    K Y+++L GID IEFP+ ISK+AQNLIKKLCR NP+ER+GYG  G+ +C KH W  +FN D LL  T+ PPI+PQ+ SPTD  NF +  P   + P DD+SGWDRDF
Sbjct:  333 FLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQ-------------FIRQMQRGEWFGEKALKDEDLRTANIIAADPA-GVDCLVLDRESYIQLIGDLTS-LQRTYEDGVNDSPKEILGPSKEYKNLALKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDAIEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNF-DEYPPETEMPPDDISGWDRDF 794          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGD-ILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDANNDINNEIREKRNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGIDTIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FLK+V   +D+  E +GKI  ++ E HY+    I  +  +    +I+ KG VK+TK+    D                +E F+ +L RG WFG+  L DE  ++  ++ A    GV+C++L++++Y+ LI D    +N + +        +R  ++  L+L+DL ++ +LG GGFGRVELVRI  DD +TFALK ++K  IVE  QQ+HVM+ER+IL++VDS+FIV+LY+TFKDR+YLYM+MEVCLGGE+W+ILREK  F+D   +F++  VI AL YLH + IV+RDLKPEN LLD +GYCKLTDFGFAK+IG  R+TWTFCGTP+YVAPEIIL  GHD A D WSLGIL+YEL +G PPF +S   KTY+++L GI TI+F   ISK AQ+LIKKLCR NPSERLGYG  G+ +  KH+WF  FN + LL +   PPIIPQV S  D  NF ++    ++ P +D+SGWD+DF
Sbjct:  406 FLKSVPTFQDMNMETLGKIAGVLGENHYSQGDYIIREGEKGATFYIIEKGRVKVTKKTSKSD----------------EEVFIRHLDRGSWFGEKALRDEDVRTA-SIIAESPSGVDCLVLDRESYNLLIGDI---VNFDKQYPDEDKARRRASKFPELALRDLCVITTLGVGGFGRVELVRIGNDDRRTFALKVLKKYHIVETHQQEHVMNERDILMEVDSEFIVKLYKTFKDRRYLYMLMEVCLGGEVWTILREKVSFDDATTKFYTASVILALEYLHRKGIVFRDLKPENCLLDEKGYCKLTDFGFAKKIGFARKTWTFCGTPEYVAPEIILNKGHDFAVDIWSLGILMYELFTGTPPFTSSDPMKTYNIILKGIQTIDFSSKISKHAQSLIKKLCRENPSERLGYGKLGVAEAQKHAWFEGFNWEGLLSKKTKPPIIPQVKSAVDVSNF-DLYSPDEETPAEDISGWDKDF 859          

Query:  822 FLKNVSILKDIPEELVGKIVDIMIEKHYAANQIIKHQNSQFTNVFIVAKGYVKLTKRNLTFDTLSADSXXXXXXXXXXXXXFLGYLSRGDWFGDILSDEQSKSPYTVTAIGADGVECIILEKDAYHQLIKDAN----NDINNEIREK-------RNQTTVKRLQQYXXXXXXXXXXXXXXXXXXXXRVELVRINKDDSKTFALKQMRKTRIVEAKQQDHVMHERNILLQVDSDFIVRLYRTFKDRKYLYMMMEVCLGGELWSILREKNRFNDLEAQFFSGCVIAALSYLHSRQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAADFWSLGILIYELLSGRPPFIASTISKTYDLVLIGID--TIEFPRYISKEAQNLIKKLCRSNPSERLGYGVEGLIKCFKHSWFSNFNADELLDQTMNPPIIPQVGSPTDRGNFGNXXXXXXXXXXXXXXGWDRDF 2243
            FL++V++ + + E  + KIV+++  + Y+  Q I  Q  +  + FI+  G+VK+T++      ++ D     +            +S G++FG+    E+ K    + A+     E + L + A+ +LI + N     + ++E R K       RN      L++     L D  ++ +LG GGFGRVELV  +KD +K++ALK M+K  IV+ KQQDHVM E+ ILL+  S +I RLY TF D KY+Y++ EVCLGGELW+ILR++  F+D    F   CV+ ALSYLHSR IVYRDLKPENLL+ + GY KL DFGFAK+IG G RTWTFCGTP+YVAPEIIL   HD + DFWS+GIL YELL+G PPF+A+   K Y++ L GI+   I     I+ +A +LI++LCR  P ERLG G  G+ +   H +F  F+ + +   T+  P  P++  P D  NF +      D P D+ SGWD+DF
Sbjct:  251 FLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK------INGDEIEVRE------------MSSGEYFGEKALLEEGKRTANIYAVKGP-TEVLCLYRQAFSELIGELNVLQAKEYDDESRAKMSLSMHSRNSAESNNLKR-ESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITSFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPIDTSNF-DKFTNESDIPPDENSGWDKDF 716